Author: admin

  • £50,000 grant secured to help more West Berkshire residents charge electric vehicles (EVs) at home

    £50,000 grant secured to help more West Berkshire residents charge electric vehicles (EVs) at home


    Funding will support safe cross-pavement charging solutions for households without driveways

    West Berkshire Council has secured £50,000 through the Department for Transport’s EV Pavement Channel Grant to help residents without off-street parking charge their electric vehicles (EVs) safely and affordably near or at their home.

    The funding will support the installation of cross-pavement charging channels – a practical solution that allows residents to run a charging cable across the pavement without creating a trip hazard. This will make home charging possible for households who do not have off-street parking.

    Being able to use domestic electricity tariffs, which are often significantly cheaper than public charging points, will help reduce costs for EV owners and encourage more residents to consider switching to cleaner vehicles. This supports the Council’s wider goals to cut carbon emissions and improve local air quality.

    The grant will cover the cost of the Section 178 Licence, which residents would normally pay for when applying for a cross-pavement channel installation. Some households may also be eligible for an additional Government grant to help fund both the charge point and the charging channel (see here for more details).

    Cllr Stuart Gourley, Executive Member for Environment and Transport at West Berkshire Council, said:

    “We know that many residents want to switch to electric vehicles but are held back because they cannot charge at home. This funding helps us remove a major barrier by making safe, affordable home charging an option for more people.

    “It’s an important step in supporting cleaner travel and improving air quality across West Berkshire. We’re proud to lead initiatives that not only reduce emissions but also empower local communities to embrace sustainable energy solutions.”

    Aviation, Maritime and Decarbonisation Minister, Keir Mather, said:

    “Our investment is backing the rollout of EV chargers in West Berkshire and helping residents install home charging solutions more easily and cheaply, so they can charge up for as little as 2p per mile.

    “We know home charging isn’t just for those with driveways, and that’s why we have a national £25 million scheme to help people install discreet cross-pavement gullies.

    “Alongside this we’re also tackling upfront costs with £1.3 billion announced at the Budget to extend the Electric Car Grant to 2030, saving drivers up to £3,750 off new EVs, alongside an extra £200 million to rollout more public chargers.”

    Full guidance and application details are available at: www.westberks.gov.uk/evguidance.

    We are delighted to be among the first local authorities to receive this funding, demonstrating our proactive approach to expanding sustainable transport options and ensuring fair access to EV charging for all residents.

     

    Continue Reading

  • Optics / Photonics Information | AZoOptics.com

    Optics / Photonics Information | AZoOptics.com

    While we only use edited and approved content for Azthena
    answers, it may on occasions provide incorrect responses.
    Please confirm any data provided with the related suppliers or

    Continue Reading

  • Department of State to Add “Specialized Trainers” to B-1, Business Traveler, Eligibility List | News & Events

    Department of State to Add “Specialized Trainers” to B-1, Business Traveler, Eligibility List | News & Events

    On Dec. 4, 2025, the U.S. Dept. of State updated its Foreign Affairs Manual to add “Specialized Trainers” to its list of eligible activities for B-1, Business Visitor visa issuance. This update comes as discussions continue between U.S. and South Korean authorities, following the September 2025 ICE Workplace Enforcement Raid, to permit certain highly-specialized trainers to temporarily enter the U.S. to conduct training.

    Scope of B-1 Visas

    The B-1, Business Visitor visa permits certain Foreign Nationals to temporarily enter the U.S. for no more than 6 months to conduct certain authorized business activities that do not constitute “work” and if the Business Visitor will not receive any remuneration while in the U.S. from a U.S. entity. The determination whether the B-1 classification is appropriate is a case-by-case determination, and the following activities may fall within the scope of the B-1 visa (non-exhaustive):

    • Investors seeking investments in the U.S.
    • Attend business meetings with colleagues or customers, consult with business associates
    • Conduct contract or business negotiations
    • Attend short training (preferably classroom)
    • Take part in exhibitions, conventions or industry/professional conferences/seminars (as an attendee or as a speaker)
    • Undertake independent research
    • Certain athletes (and their personnel) or participants in international sporting events (g., the upcoming FIFA World Cup)

    Certain Commercial or Industrial Workers might also be eligible for B-1 visas if coming to the U.S. to “install, service, or repair commercial or industrial equipment or machinery,” so long as the equipment/machinery was purchased from a company outside the United States, and such post-sales services are required under the terms of the sales contract.

    Eligibility Requirements for a Specialized Trainer

    The new Specialized Trainer category is similar to that of Commercial or Industrial Workers, as the training to be conducted must be on “industrial equipment, machinery, or processes that have been acquired or are sourced from a company outside the United States,” in support of a qualifying project (such as an installation project or plant/facility ramp-up project).  Additionally, the visa applicant must show that:

    • The training or transfer of knowledge to U.S. workers will be of specialized or proprietary techniques, skills, or know-how, and
    • The visa applicant possesses unique knowledge that is not widely available in the United States (somewhat similar to the L-1B, Specialized Knowledge visa).

    If approved, the visa will be annotated “B-1 SPECIALIZED TRAINER.”

    This new category should provide greater flexibility for foreign entities doing business with U.S. companies, to provide knowledge transfer to the local workforce and to continue their investments in the United States.  It is critical, however, that foreign nationals and their employers strictly comply with the requirements of this new B-1 category while in the U.S.

    If you think you or your employee might be eligible for B-1 Specialized Trainer processing, or if you have any question regarding the content of this alert, contact a member of Clark Hill’s Immigration Law Practice.

    This publication is intended for general informational purposes only and does not constitute legal advice or a solicitation to provide legal services. The information in this publication is not intended to create, and receipt of it does not constitute, a lawyer-client relationship. Readers should not act upon this information without seeking professional legal counsel. The views and opinions expressed herein represent those of the individual author only and are not necessarily the views of Clark Hill PLC. Although we attempt to ensure that postings on our website are complete, accurate, and up to date, we assume no responsibility for their completeness, accuracy, or timeliness.

    Continue Reading

  • Money Market Mutual Funds | Federal Reserve History

    Since the 1970s, MMMFs have become important parts of short-term money markets.

    Money market mutual funds (MMMFs) arose in the 1970s. At the time, market interest rates were higher than the rates that commercial banks were permitted to pay on their deposits by federal banking regulation, spurring the growth of investment alternatives outside of banks including MMMFS. Since MMMFS are not banks, they developed largely outside of the sphere of Federal Reserve operations or regulations until the advent of severe financial crises in 2008 and 2020, when the Fed made emergency loans to support MMMFs and the broader economy. In addition, since 2013 the Fed has interacted with MMMFs regularly through open market operations in the context of implementing monetary policy.

    Early growth

    Money market funds began largely as a workaround to regulations that limited the interest rates depository institutions were allowed to pay depositors. These limits, known as Regulation Q, were required by federal law beginning in 1933 and were implemented by the Federal Reserve and other financial regulators. As interest rates rose in the 1970s, Regulation Q gave depositors an incentive to find short-term investments outside of the banking system, such as Treasury bills, commercial paper, and repurchase agreements. MMMFs offered consumers the ability to invest in those instruments with some additional conveniences, including the ability to withdraw funds at any time, diversify across instruments, choose any specific investment size, and economize on administrative expenses.

    These basic forces led to the establishment of the first MMMF in 1972. The number of funds grew to 36 in 1975, 90 in 1980, and 649 in 1990.1

    Officials at depository institutions such as banks expressed concern that they could not compete with the interest rates offered by MMMFs. At times in the 1970s, depository institutions lost substantial amounts of funds to MMMFs. Officials at small banks protested that they were at a particular disadvantage, since MMMFs returned some funds to large banks by investing in their certificates of deposit, but did not invest in CDs at smaller banks. Federal Reserve officials agreed that interest rate regulations should be adjusted to level the playing field, and so did Congress. Governor J. Charles Partee, for example, testified in 1980 that the Federal Reserve supported the “gradual deregulation of maximum rates payable on deposit instruments” rather than extending controls to money market funds, which was another proposal at the time (Partee 1980). The Monetary Control Act of 1980 required the phasing out of regulations on saving deposit interest rates. Thus, the presence of MMMFs played a central role in the unwinding of these 1930s-era regulations.

    Episodes of losses and runs

    Market participants and regulators were aware of the risk of runs on MMMFs soon after the first ones were established (Bouveret, Martin, and McCabe 2022). For example, in the 1978 edition of The Money Market (p. 78), Marcia Stigum posed the following hypothetical:

    “Suppose short-term interest rates were to rise sharply; then the market value of the securities in the fund’s portfolio would be temporarily depressed. Suppose also that a large number of investors simultaneously redeemed their fund shares for cash. It is conceivable that such a fund would be forced to sell off some of its securities at a loss, and that the actual market value of the securities backing its remaining outstanding shares would fall below its fixed share value. In that case, if redemptions continued, the fund would run out of money before all shares were redeemed.”

    MMMFs are vulnerable to runs because they use accounting methods designed to provide a stable share value, typically $1.00. If investors perceive that a fund has or will have losses, investors have an incentive to be the first to withdraw at the fixed value, leaving losses for the remaining investors to absorb.

    Run risk was largely unrealized during the first few decades of operations at MMMFs, though some episodes of losses did occur. In 1980, abrupt and large increases in interest rates caused losses for one MMMF. In 1989 and 1990, defaults of two commercial paper issuers caused losses for about a dozen MMMFs. In 1994, investments in derivatives tied to interest rates led to losses again for about a dozen MMMFs. In all these cases except one, investors did not lose money because losses were covered by the financial institutions that sponsored the funds. The exception was the Community Bankers U.S. Government Fund, which in 1994 became the first money market fund to “break the buck” and fail because its assets were worth less than $1.00 per share. No sector-wide run developed, though.2

    A seminal moment in the history of MMMFs came in September 2008, when the Reserve Primary Fund suffered losses on commercial paper issued by Lehman Brothers. Investors staged a run, which quickly spread to affect many other money market funds. Over $400 billion was withdrawn from prime MMMFs, i.e., those that invested not just in safe government debt but also in somewhat riskier assets such as commercial paper (Makhija 2025). MMMFs experienced a second major episode of severe runs in 2020 at the onset of the pandemic.

    To protect investors, the Securities and Exchange Commission issued its first regulation governing MMMFs in 1977. That regulation sought to limit the use of certain accounting practices that supported fixed $1.00 valuations (SEC 1977).3 However, after strong resistance from the industry, the SEC issued exemptions to that rule and then switched approaches with a new rule issued in 1983, known as rule 2a-7. This rule, which has since been revised several times, has governed several practices at MMMFs, including limitations on the maturity, credit quality, and liquidity of MMMF investments (Investment Company Institute 2012). After the 2008 crisis, the SEC revised this rule to allow funds to impose gates or fees to stop runs. However, in practice, the potential for MMMFs to impose gates or fees exacerbated runs in 2020 rather than preventing them, and revisions in 2023 largely removed the gates and fees. Much MMMF activity has migrated into funds that can invest only in government securities, which are subject to less stringent regulation because of the relative safety of those investments.

    Federal Reserve lender-of-last-resort interactions with MMMFs

    MMMFs are not depository institutions, so they do not normally have access to loans from the Federal Reserve. However, the Federal Reserve is the lender of last resort to the American financial system, and in exigent and unusual circumstances Federal Reserve Banks can extend loans more widely. These powers were invoked in 2008 and 2020 to make loans that supported MMMFs amidst the severe runs on these funds. Federal Reserve officials were concerned that the disruption of MMMFs could significantly impact economic activity. In particular, because MMMFs could not continue their normal purchases of commercial paper, large corporations that depended on the commercial paper market encountered severe strains.

    In both 2008 and 2020, the Federal Reserve made loans to banks that purchased commercial paper from MMMFs. In 2008, the facility that accomplished this effort was named the Asset-Backed Commercial Paper Money Market Mutual Fund Liquidity Facility. In 2020, a similar facility was named the Money Market Fund Liquidity Facility. In 2008, the Fed created two additional facilities, reflecting the severity of that crisis. In the Commercial Paper Funding Facility, the Fed made loans to a limited liability company that purchased newly issued commercial paper. The Fed also made loans available directly to MMMFs in the Money Market Investor Funding Facility, though this facility was never used.

    Federal Reserve monetary policy interactions with MMMFs

    The growth of MMMFs in the 1970s first began to affect the Fed’s conduct of monetary policy by affecting measurements of the money stock. Because investors used MMMFs as substitutes for deposit accounts, flows between deposits and MMMFs made existing money stock measures volatile and less useful (Partee 1980). As a result, the Board of Governors redefined monetary aggregates in 1980 to include MMMFs in the M2 money stock measure (Simpson 1980).4

    While bank and thrift deposits are subject to reserve requirements, MMMF shares have not been. Some in Congress supported proposals to extend reserve requirements to MMMFs, as did Paul Volcker, chairman of the Board of Governors from 1979 to 1987. Volcker suggested that extending reserve requirements to MMMFs would help the Federal Reserve implement monetary policy. At the time, the Fed’s approach to monetary policy focused on targeting monetary aggregates, and reserve requirements helped make the level of those aggregates more predictable. Volcker said that “there is a clear logical case for closing a gap in a monetary control system built on the premise that reserves should be assessed against transaction balances wherever they might be held” (Volcker 1981). In addition, this proposal addressed the concerns of officials at depository institutions about an unlevel playing field; since the Federal Reserve did not pay interest on reserves at the time, banks were at a competitive disadvantage against MMMFs. Indeed, the Monetary Control Act of 1980 had extended reserve requirements to S&Ls and savings banks that were offering transaction accounts. By the same logic, Volcker and others recommended extending those requirements to MMMFs. However, Congress chose against this path. Money fund stakeholders and the SEC successfully argued that MMMFs were sufficiently distinct from banks to not warrant reserve requirements. The prevailing tide of the early 1980s was against regulation and in favor of promoting financial innovation.5

    A few decades later, the Federal Reserve began interacting with MMMFs directly in the conduct of monetary policy. In contrast to the way monetary policy was implemented in 1981, by 2013 the Fed’s approach was to target the level of short-term interest rates rather than measures of the money stock. To that end, the Fed began interacting with MMMFs through the overnight reverse repurchase facility (ON RRP). Because overnight repurchase agreements are a large part of short-term money markets, the Fed uses the facility to transact with major participants in that market, including MMMFs. The ON RRP is designed to ensure that short-term interest rates do not fall below the Federal Reserve’s target range. Participants can earn interest by temporarily selling a security to the Fed overnight and buying it back the next day at a slightly lower price.

    Conclusion

    In a 2023 interview, former Fed Chair Ben Bernanke judged that the Fed would benefit from new legislation that would fix “a structural flaw that was never corrected by Congress, which is that the Fed is restricted on normal grounds to lending only to banks and not to other types of financial institutions” (Somner 2023). The roots of these statutory limitations go back to the Fed’s establishment in 1913, when the financial system was more centered on banks and MMMFs did not yet exist. For their part, MMMF stakeholders have generally preferred that MMMFs remain outside the banking system and banking regulation.

     

    References

    Bary, Andrew. (1994) “Investors’ Money Slips Through a Crazy Loophole in Money Fund Rules.” Barron’s, October 3, p. MW10.

    Bouveret, Antoine, Antoine Martin, and Patrick E. McCabe. (2022) “Money Market Fund Vulnerabilities: A Global Perspective.” Finance and Economics Discussion Series 2022-012. Washington: Board of Governors of the Federal Reserve System. Available online.

    Carrington, Tim and Tom Herman. (1980) “How Adviser’s Gamble on Interest Rates Led to Trouble for an ILA Money Fund.” Wall Street Journal, October 9, p. 31.

    Clements, Jonathan. (1990) “Money Market Funds Shedding Lower-Grade Paper.” Wall Street Journal, October 22, p. C1.

    Foldessy, Edward P. and David J. Blum. (1980) “Salomon Brothers and Chicago Bank Act in Bid to Avert Run on Big Money Fund.” Wall Street Journal, October 8, p. 3.

    Hershey, Robert D. (1973) “Overnight Mutual Funds for Surplus Assets,” New York Times, January 7, p. 163.

    Investment Company Institute. (2012) “History of Rule 2a-7 – The Evolution of Money Market Fund Regulation.” Available online.

    Jasen, Georgette and Jeffrey Taylor. (1994) “Derivatives Force First Closure of Money Fund.” Wall Street Journal, September 28, p. C1.

    Laing, Jonathan R. (1990) “Never Say Never—Or, How Safe is Your Money Market Fund?” Barron’s, March 26, p. 6.

    Makhija, Anmol. (2025) “United States: Reserve Primary Fund Suspension, 2008.” Journal of Financial Crises, vol. 7 no. 2.

    Partee, J. Charles. (1980) Statement before the Subcommittee on Financial Institutions of the Committee on Banking, Housing and Urban Affairs, United States Senate. January 24. Available on FRASER.

    Securities and Exchange Commission (1977). Valuation of Debt Instruments by Money Market Funds and Certain Other Open-End Investment Companies. Federal Register, vol. 42. No. 109, June 7, p. 28999. Available on FRASER.

    Securities and Exchange Commission (1990). Revision to Rules Regulating Money Market Funds. Federal Register, vol. 25 no. 143, July 25, p. 30239. Available on FRASER.

    Simpson, Thomas D. (1980) “The Redefined Monetary Aggregates.” Federal Reserve Bulletin, February, pp. 97-114. Available on FRASER.

    Somner, Jeff. (2023) “Ben Bernanke Talks About Bank Runs, Inflation, A.I., Market Bubbles, and More.” New York Times, June 9.

    Stigum, Marcia. (1978) The Money Market: Myth, Reality, and Practice. Dow Jones-Irwin.

    Subcommittee on Financial Institutions of the Committee on Banking, Housing, and Urban Affairs, United States Senate (1980). Hearings on Money Market Mutual Funds. Available on FRASER.

    Volcker, Paul A. (1981) Statement before the Subcommittee on Domestic Monetary Policy, Committee on Banking, Finance and Urban Affairs, June 25. Available on FRASER.


    Published December 12, 2025. Jonathan Rose contributed to this article. Please cite this essay as: Federal Reserve History. “Money Market Mutual Funds.” December 12, 2025. See disclaimer and update policy.

    Continue Reading

  • Phase 3 STAR-221 Study of First-Line Domvanalimab/Zimberelimab Plus Chemo in Upper GI Cancers to Be Discontinued

    Phase 3 STAR-221 Study of First-Line Domvanalimab/Zimberelimab Plus Chemo in Upper GI Cancers to Be Discontinued

    The phase 3 STAR-221 study (NCT05568095) evaluating the anti-TIGIT antibody domvanalimab in combination with the anti–PD-1 antibody zimberelimab and chemotherapy as a first-line treatment for patients with advanced gastric and esophageal cancers is being discontinued due to futility, following a recommendation from the study’s independent data monitoring committee.1

    The committee’s recommendation followed a review of data from a prespecified interim analysis of overall survival (OS) of STAR-221, at which time the domvanalimab-based combination did not improve OS compared with nivolumab (Opdivo) plus chemotherapy. The regimen’s safety profile was comparable to that of nivolumab plus chemotherapy, and no new safety data were identified.

    “Patients in the domvanalimab-containing arm derived the same benefit as patients treated in the control arm, and there were no new safety concerns,” Richard Markus, MD, chief medical officer of Arcus Biosciences, stated in a news release. “We are disappointed with this outcome and sincerely thank all those who participated in the study and made this research possible. We remain committed to advancing research for people living with cancer and immune-related diseases.”

    In addition to STAR-221, the ongoing, multi-arm, global phase 2 EDGE-Gastric study (NCT05329766) evaluating the safety and efficacy of various domvanalimab-based and zimberelimab-based combinations in locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), or esophageal adenocarcinoma, will also be discontinued.1,2

    Arcus Biosciences and Gilead Sciences, the co-developers of domvanalimab, are currently in communication with study investigators to determine appropriate next steps for patients in the study. A detailed analysis will be conducted to further clarify these results.

    “The results from STAR-221 are not what we had hoped for, and we have important work ahead to meet the needs of patients on our domvanalimab studies and also accelerate the casdatifan [AB521] and inflammation and immunology programs,” Terry Rosen, chief executive officer of Arcus, added in a news release.1 “We are fortunate to be well capitalized and plan to focus our resources on casdatifan, including studying new early-line combinations in kidney cancer, broadening its development into new tumor types, and extending our capabilities beyond oncology.”

    What prior data were reported with domvanalimab plus zimberelimab and chemotherapy in EDGE-Gastric?

    Arm A1 of EDGE-Gastric enrolled treatment-naive patients with locally advanced unresectable or metastatic gastric, GEJ, or esophageal adenocarcinoma.2,3 All patients received 1600 mg of domvanalimab and 480 mg of zimberelimab intravenously every 4 weeks, plus chemotherapy every 2 weeks, until disease progression or unacceptable toxicity.

    Domvanalimab Plus Zimberelimab and Chemotherapy: Reasons for Discontinued Development

    • The phase 3 STAR-221 study evaluating first-line domvanalimab plus zimberelimab and chemotherapy for advanced gastric and esophageal cancers is being discontinued due to futility.
    • This decision was recommended by the study’s independent data monitoring committee after a review of data from a prespecified interim analysis failed to show improved OS with the combination vs nivolumab plus chemotherapy.
    • The phase 2 EDGE-Gastric study, which is evaluating various combinations of domvanalimab plus zimberelimab and chemotherapy in advanced GI cancers, is also being discontinued.

    The study’s coprimary end points were investigator-assessed overall response rate (ORR) and safety.3 Secondary end points included OS, progression-free survival (PFS), disease control rate, and duration of response (DOR) in both the overall patient population and in PD-L1 expression subgroups.

    First OS results and updated efficacy findings from arm 1 of EDGE-Gastric were presented during the 2025 ESMO Congress.2 At the data cutoff of March 3, 2025, and a median follow-up of 26.4 months, domvanalimab plus zimberelimab and chemotherapy produced a median OS of 26.7 months (90% CI, 18.4-not evaluable) and a median PFS of 12.9 months (90% CI, 9.8-14.6) in the overall patient population (n = 41). The confirmed ORR per RECIST 1.1 criteria was 59% (90% CI, 45%-72%). No unexpected safety signals were observed at the time of data cutoff, and the regimen was generally well tolerated.

    Results from EDGE-Gastric supported the ongoing development of this regimen in STAR-221.

    What was the design of STAR-221?

    STAR-221 was a global, randomized, open-label, phase 3 trial evaluating domvanalimab plus zimberelimab and chemotherapy vs nivolumab plus chemotherapy as frontline therapy for patients with locally advanced, unresectable or metastatic HER2-negative gastric, GEJ, and esophageal adenocarcinomas.2 The study enrolled 1,040 patients from approximately 30 countries.

    Patients were randomly assigned 1:1 to one of 2 treatment arms: 1600 mg of IV domvanalimab plus 480mg of zimberelimab IV every 4 weeks and FOLFOX (oxaliplatin, leucovorin, fluorouracil) every 2 weeks, or 1200 mg of domvanalimab plus 360 mg of zimberelimab every 3 weeks and CAPOX (capecitabine and oxaliplatin) every 3 weeks; vs 240mg of nivolumab IV and FOLFOX every 2 weeks, or 360 mg of nivolumab plus CAPOX every 3 weeks.

    The study’s primary end points were OS in PD-L1–high tumors, PD-L1–positive tumors, and in the intention-to-treat population. PFS, ORR, DOR, safety, and patient-reported outcomes all served as secondary end points.

    References

    1. Arcus provides update on phase 3 STAR-221 study and concentrates its R&D investment on casdatifan and emerging inflammation and immunology portfolio. News release. Coherus. December 12, 2025. Accessed December 12, 2025. https://investors.arcusbio.com/investors-and-media/press-releases/press-release-details/2025/Arcus-Provides-Update-on-Phase-3-STAR-221-Study-and-Concentrates-Its-RD-Investment-on-Casdatifan-and-Emerging-Inflammation-and-Immunology-Portfolio/default.aspx
    2. Anti-TIGIT domvanalimab plus anti-PD-1 zimberelimab and chemotherapy showed 26.7 months of median overall survival as first-line treatment of unresectable or advanced gastroesophageal adenocarcinomas in the phase 2 EDGE-Gastric study. News Release. Arcus Biosciences. October 12, 2025. December 12, 2025. https://investors.arcusbio.com/investors-and-media/press-releases/press-release-details/2025/Anti-TIGIT-Domvanalimab-Plus-Anti-PD-1-Zimberelimab-and-Chemotherapy-Showed-26-7-Months-of-Median-Overall-Survival-as-First-Line-Treatment-of-Unresectable-or-Advanced-Gastroesophageal-Adenocarcinomas-in-the-Phase-2-EDGE-Gastric-Study/default.aspx
    3. Janjigian YY, Oh DY, Pelster M, Wainberg ZA, Prusty S, Nelson S, DuPage A, Thompson A, Koralek DO, Sison EAR, Rha SY. Domvanalimab and zimberelimab in advanced gastric, gastroesophageal junction or esophageal cancer: a phase 2 trial. Nat Med.(2025). doi: 10.1038/s41591-025-04022-w.

    Continue Reading

  • Jersey and Guernsey residents urged to help slow spread of flu

    Jersey and Guernsey residents urged to help slow spread of flu

    Islanders should stay at home and avoid visiting elderly and vulnerable people if they have the flu, officials have urged.

    Experts said flu had come early this winter and they predict it could be a particularly nasty season because of a new…

    Continue Reading

  • Making clean energy investments more successful | MIT News

    Making clean energy investments more successful | MIT News

    Governments and companies constantly face decisions about how to allocate finite amounts of money to clean energy technologies that can make a difference to the world’s climate, its economies, and to society as a whole. The process is inherently uncertain, but research has been shown to help predict which technologies will be most successful. Using data-driven bases for such decisions can have a significant impact on allowing more informed decisions that produce the desired results.

    The role of these predictive tools, and the areas where further research is needed, are addressed in a perspective article published Nov. 24 in Nature Energy, by professor Jessika Trancik of MIT’s Sociotechnical Systems Research Center and Institute of Data, Systems, and Society and 13 co-authors from institutions around the world.

    She and her co-authors span engineering and social science and share “a common interest in understanding how to best use data and models to inform decisions that influence how technology evolves,” Trancik says. They are interested in “analyzing many evolving technologies — rather than focusing on developing only one particular technology — to understand which ones can deliver.” Their paper is aimed at companies and governments, as well as researchers. “Increasingly, companies have as much agency as governments over these technology portfolio decisions,” she says, “although government policy can still do a lot because it can provide a sort of signal across the market.”

    The study looked at three stages of the process, starting with forecasting the actual technological changes that are likely to play important roles in coming years, then looking at how those changes could affect economic, social, and environmental conditions, and finally, how to apply these insights into the actual decision-making processes as they occur.

    Forecasting usually falls into two categories, either data-driven or expert-driven, or a combination of those. That provides an estimate of how technologies may be improving, as well as an estimate of the uncertainties in those predictions. Then in the next step, a variety of models are applied that are “very wide ranging,” Trancik says, “different models that cover energy systems, transportation systems, electricity, and also integrated assessment models that look at the impact of technology on the environment and on the economy.”

    And then, the third step is “finding structured ways to use the information from predictive models to interact with people that may be using that information to inform their decision-making process,” she says. “In all three of these steps, how you need to recognize the vast uncertainty and tease out the predictive aspects. How you deal with uncertainty is really important.”

    In the implementation of these decisions, “people may have different objectives, or they may have the same objective but different beliefs about how to get there. And so, part of the research is bringing in this quantitative analysis, these research results, into that process,” Trancik says. And a very important aspect of that third step, she adds, is “recognizing that it’s not just about presenting the model results and saying, ‘here you go, this is the right answer.’ Rather, you have to bring people into the process of designing the studies and interacting with the modeling results.”

    She adds that “the role of research is to provide information to, in this case, the decision-making processes. It’s not the role of the researchers to push for one outcome or another, in terms of balancing the trade-offs,” such as between economic, environmental, and social equity concerns. It’s about providing information, not just for the decision-makers themselves, but also for the public who may influence those decisions. “I do think it’s relevant for the public to think about this, and to think about the agency that actually they could have over how technology is evolving.”

    In the study, the team highlighted priorities for further research that needs to be done. Those priorities, Trancik says, include “streamlining and validating models, and also streamlining data collection,” because these days “we often have more data than we need, just tons of data,” and yet “there’s often a scarcity of data in certain key areas like technology performance and evolution. How technologies evolve is just so important in influencing our daily lives, yet it’s hard sometimes to access good representative data on what’s actually happening with this technology.” But she sees opportunities for concerted efforts to assemble large, comprehensive data on technology from publicly available sources.

    Trancik points out that many models are developed to represent some real-world process, and “it’s very important to test how well that model does against reality,” for example by using the model to “predict” some event whose outcome is already known and then “seeing how far off you are.” That’s easier to do with a more streamlined model, she says.

    “It’s tempting to develop a model that includes many, many parameters and lots of different detail. But often what you need to do is only include detail that’s relevant for the particular question you’re asking, and that allows you to make your model simpler.” Sometimes that means you can simplify the decision down to just solving an equation, and other times, “you need to simulate things, but you can still validate the model against real-world data that you have.”

    “The scale of energy and climate problems mean there is much more to do,” says Gregory Nemet, faculty chair in business and regulation at the University of Wisconsin at Madison, who was a co-author of the paper. He adds, “while we can’t accurately forecast individual technologies on their own, a variety of methods have been developed that in conjunction can enable decision-makers to make public dollars go much further, and enhance the likelihood that future investments create strong public benefits.”

    This work is perhaps particularly relevant now, Trancik says, in helping to address global challenges including climate change and meeting energy demand, which were in focus at the global climate conference COP 30 that just took place in Brazil. “I think with big societal challenges like climate change, always a key question is, ‘how do you make progress with limited time and limited financial resources?’” This research, she stresses, “is all about that. It’s about using data, using knowledge that’s out there, expertise that’s out there, drawing out the relevant parts of all of that, to allow people and society to be more deliberate and successful about how they’re making decisions about investing in technology.”

    As with other areas such as epidemiology, where the power of analytical forecasting may be more widely appreciated, she says, “in other areas of technology as well, there’s a lot we can do to anticipate where things are going, how technology is evolving at the global or at the national scale … There are these macro-level trends that you can steer in certain directions, that we actually have more agency over as a society than we might recognize.”

    The study included researchers in Massachusetts, Wisconsin, Colorado, Maryland, Maine, California, Austria, Norway, Mexico, Finland, Italy, the U.K., and the Netherlands. 

    Continue Reading

  • The Playboy of the Western World review – Nicola Coughlan serves comedy and tragedy in pub drama | National Theatre

    The Playboy of the Western World review – Nicola Coughlan serves comedy and tragedy in pub drama | National Theatre

    Every woman loves a bad boy, or so the cliche goes. Here it is tested when Christy Mahon walks into a pub to confess he has killed his father with a farming tool. It’s not quite the truth but he is, to his own surprise, turned into a local…

    Continue Reading

  • Science sleuths raise concerns about scores of bioengineering papers

    Science sleuths raise concerns about scores of bioengineering papers

    Image sleuths noticed irregularities in figures from scores of papers co-authored by Ali Khademhosseini.Credit: Natali Mis/Getty

    In December 2024, Elisabeth Bik noticed irregularities in a few papers by a highly-cited bioengineer, Ali…

    Continue Reading

  • Donald Trump fails to secure ceasefire between Thailand and Cambodia as border conflict continues

    Donald Trump fails to secure ceasefire between Thailand and Cambodia as border conflict continues

    Donald Trump has failed to secure a peace deal between Thailand and Cambodia as the neighbouring countries continue to clash at the border for a fifth day.

    The US president called his Thai counterpart, Anutin Charnvirakul, on Friday, after…

    Continue Reading