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  • Synthetic Lethality in Oncology: Challenges, Trials & Future Therapies (2025 Update)

    A strategy targeting paired genetic weaknesses in cancer cells, where simultaneous disruption kills cancer cells while sparing normal cells, this is called synthetic lethality.

    Advances in genome sequencing are transforming…

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  • Dow, S&P 500 end at records because investors feel good about the economy – beyond the AI boom

    Dow, S&P 500 end at records because investors feel good about the economy – beyond the AI boom

    By Joy Wiltermuth and Gordon Gottsegen

    Investors moving away from tech stocks, and using that money to push other parts of the market to new records

    Investors are back betting on the economy, beyond the AI boom.

    The Dow Jones Industrial Average and S&P 500 index both scored record finishes Thursday, elevated by the Federal Reserve’s rate cut a day earlier and optimism about the economy that’s finally put a new shine on old-school components of the stock market.

    The Dow’s DJIA biggest gainers were Visa Inc. (V), Nike Inc. (NKE) and Goldman Sachs Group Inc. (GS), according to FactSet data. Shares of artificial-intelligence darling Nvidia Corp. (NVDA) were its biggest loser.

    “The Fed rate cut – even if there’s been some hand-wringing about dissents – it helps nail down a constructive view of the economy,” said Paul Christopher, head of global investment strategy at the Wells Fargo Investment Institute. “That’s why you are seeing materials, financials and industrial stocks doing better today.”

    While the Dow gained 646.26 points, or 1.3%, to close at a record 48,704.01, it’s notable that the equal-weight version of the S&P 500 index XX:SP500EW outperformed the S&P 500 SPX and its lopsided weighting to a few large-cap tech stocks.

    Non-tech sectors also finished higher on Thursday. The materials sector, which was the worst-performing sector over the past three months, was Thursday’s top performing sector, with the S&P 500 Materials Sector Index XX:SP500.15 gaining 2.2% on the day. The S&P 500 Industrials Sector Index XX:SP500.20 and S&P 500 Financials Sector Index XX:SP500.40 ended the day at record closes. It was the first time the industrials sector closed at a record since September, according to Dow Jones Market Data.

    Beyond rate cuts boosting broader parts of the market, there are also expectations that bigger tax refunds for people and businesses will drive more optimism about the economy.

    See: Bigger tax refunds – up to $2,000 on average – could give stocks a boost next year

    AI jitters return

    The broadening out of the rally followed mixed earnings from Oracle Corp. (ORCL), the new poster child for fears about Big Tech companies splurging on debt in the AI race without a clearly defined endgame.

    Investors have been growing increasingly wary about companies borrowing money for their AI buildout plans. Jeffrey Rosenkranz, a portfolio manager at Shelton Capital Management, told MarketWatch that you can see this play out by looking at Oracle’s corporate debt. Oracle’s credit spreads have moved significantly wider in a relatively short period of time.

    In turn, these moves in the debt market have influenced equity prices too. Oracle’s stock fell 10.8% on Thursday.

    “The market believes they’re going to be the largest borrower for this AI spending boom. They’re concerned it’s stressing their balance sheet,” Rosenkranz said.

    But Oracle isn’t the only company getting this investor scrutiny. Other tech companies, like Meta Platforms Inc.( META) and Amazon.com Inc. (AMZN), have seen their shares sell off following news about AI spending.

    “There’s some fatigue around the rally in tech,” said Christopher at Wells, noting that tremors around AI plays in August and October intensified in November, as more people questioned when several trillion dollars in expected spending will pay off.

    “The theme will return,” he said, “And it will simply be punctuated by these rug-pulling announcements, where the market keeps asking the same questions.”

    Read: Oracle drags down Nvidia and other AI stocks as bubble fears intensify

    Betting on the economy

    A chief concern all year has been both the stock market’s and economy’s reliance on the AI boom.

    “Tech has had a really good year, but in the near term there’s a lack of a catalyst,” said Keith Lerner, chief market strategist at Truist Advisory Services, following Oracle’s disappointing earnings. “The market is thinking: ‘What other areas can we look at?’”

    With the Fed now having cut its benchmark policy rate to a 3.5% to 3.75% range, it sits closer to a more “neutral” level for the economy.

    That’s helped broaden the rally and raised interest in stocks that are more “leveraged to the economy,” said Lerner, noting that rate-sensitive parts of the market, including small-cap stocks, have been doing well.

    The small-cap Russell 2000 index RUT closed at a new record on Thursday, adding to its recent string of record closes. The index has traded higher five of the past seven trading days as investors anticipated the rate cut.

    “Smaller companies are doing well today in the wake of the yesterday’s Fed rate cut because they typically benefit from lower rates more than larger companies. That’s because when small companies borrow money they are more likely to get an interest rate linked to market rates,” Stephen Callahan, trading behavior specialist at Firstrade, told MarketWatch.

    Of note, the Dow outperformed the S&P 500 by 1.1% percentage points on Thursday, marking its largest one-day outperformance since Feb. 27, according to Dow Jones Market Data.

    Longer-duration bond yields that finance businesses, households and the economy also have been pretty steady since the Fed’s rate cut on Wednesday, with the 10-year Treasury yield BX:TMUBMUSD10Yat 4.14% on Thursday.

    Also of note, while investors were back to questioning AI plays on Thursday, strategists said that doesn’t mean people have been wholesale throwing in the towel on tech.

    “To me, it’s more of a normal rotation, and the market is shifting on a short-term basis to broadening theme,” Lerner said. “It’s about confidence in the stability of the economy.”

    -Mike DeStefano and Chelsea Ng contributed

    -Joy Wiltermuth -Gordon Gottsegen

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

    (END) Dow Jones Newswires

    12-11-25 1651ET

    Copyright (c) 2025 Dow Jones & Company, Inc.

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  • Harmonies of Hope raises $2.3 million and counting for Hurricane Melissa relief in Jamaica — Ron Fanfair

    Harmonies of Hope raises $2.3 million and counting for Hurricane Melissa relief in Jamaica — Ron Fanfair

    Despite the significant damage caused by Hurricane Melissa, recovery efforts are progressing rapidly and with great determination. Estimates place the physical damage from the hurricane, which devastated the western part of the island, at…

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  • Evaluation of Albumin Platelet Product for Fibrosis Detection in MASLD

    Evaluation of Albumin Platelet Product for Fibrosis Detection in MASLD

    A retrospective cohort study of 570 patients with either metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH) has found that a novel blood-based biomarker, albumin platelet…

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  • New Tsallis Holographic Energy In Rastall Theory Constrains Cosmological Parameters With DESI And PantheonPlus Data

    New Tsallis Holographic Energy In Rastall Theory Constrains Cosmological Parameters With DESI And PantheonPlus Data

    The accelerating expansion of the universe drives research into the nature of dark energy, and a new study explores a compelling candidate using a combination of theoretical frameworks, namely New Tsallis holographic energy and Rastall…

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  • 2026 North American Corporate Credit Outlook Neutral on Stable Economy, Lower Rates – Fitch Ratings

    1. 2026 North American Corporate Credit Outlook Neutral on Stable Economy, Lower Rates  Fitch Ratings
    2. 2026 Outlook: Corporate Credit – Charles Schwab – Commentaries  Advisor Perspectives
    3. Fitch Ratings: 2026 North American Corporate Credit Outlook Neutral on Stable Economy, Lower Rates  TradingView
    4. Fitch Ratings: North American Sovereign Outlook Remains ‘Neutral’ for 2026  TradingView

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  • Prime Video’s Fallout Season 1 Recap Has Inaccurate AI Slop

    Prime Video’s Fallout Season 1 Recap Has Inaccurate AI Slop

    We may receive a commission on purchases made from links.

    You know how these days, you wake up most mornings and feel like you’ve been punched in the face when you check the news? Well, I’m here to make it worse and tell you that, while promoting…

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  • After Airbus issue, DOT says airlines don’t have to cover passenger expenses amid aircraft recalls

    After Airbus issue, DOT says airlines don’t have to cover passenger expenses amid aircraft recalls

    The U.S. Department of Transportation has issued new guidance telling airlines they do not have to cover passenger expenses, such as meals or hotel stays, when flight cancellations or long delays are caused by aircraft recalls.

    The guidance, released on Wednesday, comes after widespread disruptions last month amid the busy Thanksgiving travel period in the U.S. stemming from inspections and software updates that carriers had to perform immediately for safety reasons on a widely used Airbus commercial aircraft. About 6,000 planes were impacted.

    Airlines worldwide scrambled to fix a computer code issue that may have contributed to a sudden drop in altitude on a JetBlue plane in October, which injured at least 15 people. Airbus said an examination of the JetBlue ordeal found a software glitch that could have affected flight-control systems on its A320 family of aircraft, the primary competitor to Boeing’s 737 planes.

    In the U.S., airlines must provide full refunds when they cancel a flight, regardless of the reason. But the Transportation Department does not require them to cover lodging or meals for stranded passengers — even when a disruption is the airline’s fault.

    Instead, airlines voluntarily offer varying levels of compensation for disruptions caused by something considered within their control, such as crew scheduling issues or mechanical problems, and the department says carriers must adhere to their commitments.

    Ten U.S. airlines, for example, offer meal vouchers when a passenger is left waiting three or more hours for a new flight after a “controllable” cancellation or a delay. They include legacy carriers Delta Air Lines, American Airlines and United Airlines, as well as low-cost carriers like Allegiant Air and Spirit Airlines. All but one of them — Frontier Airlines — promise to cover lodging for passengers if they cause an overnight cancellation or delay.

    The new DOT guidance clarifies that disruptions caused by aircraft recalls are not categorized as “within an airline’s control,” meaning those voluntary customer service commitments do not apply, although carriers can still offer them if they choose to do so.

    The department said the guidance will remain in place while it continues rule-making on how flight disruptions should be categorized.

    In September, the Trump administration scrapped a Biden-era proposal to make it mandatory instead of voluntary to provide compensation to passengers for major disruptions caused by an airline, which would have brought U.S. policy closer in line with European airline consumer protections.

    The Transportation Department said at the time that the move was “consistent with Department and administration priorities.” President Donald Trump has sought to significantly roll back or modify federal regulations that his administration deems are wasteful or burdensome.

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  • MIT researchers find new immunotherapeutic targets for glioblastoma | MIT News

    MIT researchers find new immunotherapeutic targets for glioblastoma | MIT News

    Glioblastoma is the most common form of brain cancer in adults, and its consequences are usually quick and fatal. After receiving standard-of-care treatment (surgery followed by radiation and chemotherapy), fewer than…

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  • Tokenization Trending: Statement on the Division of Trading and Market’s No-Action Letter Related to DTC’s Development of Securities Tokenization Services

    Today, the staff of the Division of Trading and Markets issued a no-action letter to The Depository Trust Company (“DTC”). The letter relates to DTC’s development and launch of a preliminary version of its voluntary securities tokenization program on supported blockchains that meet DTC’s technology standards. This program will enable the tokenization of security entitlements to certain eligible securities that DTC’s participants hold through DTC (“tokenized entitlements”). Any DTC participant with a registered wallet will be able to transfer its tokenized entitlement directly to the registered wallet of another DTC participant. DTC’s software system will track each transfer to record tokenization entitlements for DTC’s official books and records.

    Although this program is a pilot subject to various operational limitations, it marks a significant incremental step in moving markets onchain. DTC plays a central role in our securities markets. I am looking forward to seeing how DTC’s participants benefit from this program and the extent to which DTC’s tokenization model can enhance the functioning of our securities markets.

    DTC’s tokenized entitlement model is a promising step along the tokenization journey, but other market participants are exploring alternate experimental avenues. As I have said repeatedly, the Commission’s crypto work is iterative. We welcome and expect other market participants’ continuing efforts to innovate and experiment. Their experiments may involve other securities tokenization models. Investor choice is critical, particularly at this early stage when the market is testing what works. For example, some issuers have begun tokenizing their own securities, which may make it easier for investors to hold and transact in securities directly, rather than through an intermediary. As I previously cautioned, market participants should be aware that different tokenization structures may raise distinct regulatory considerations.[1]

    I want to thank Director Jamie Selway and his staff in the Division of Trading and Markets for their diligent work on issuing this important no-action letter.

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