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  • “I’m better at making shoes than you are at anything.”

    “I’m better at making shoes than you are at anything.”

    Brennan Lee Mulligan has announced his “exit” from Dropout, stating he will dedicate himself to making custom shoes for American Girl dolls, in what appears to be a comedic sketch shared on Game Changer Shorts.

    The long-time Dimension 20 gamemaster and Dropout creator said in the video, “Effective immediately, I will no longer be with Dropout.tv,” adding, “There is no bad blood between us. There’s no drama.”

    Mulligan explained his decision, saying he wanted to focus on the “craft and profession of making custom shoes for American Girl dolls,” referencing characters like Kit and Melody while criticising the dolls’ current footwear for historical inaccuracy.

    In the announcement, Mulligan joked about following Daniel Day-Lewis’s path, saying, “Daniel D. Lewis left Hollywood to make shoes… I’m going to make smaller shoes and I’m better than him.”

    The video prompted Dropout to launch a website, brennansamericangirldollshoes.com, using the tagline: “I’m better at making shoes than you are at anything.”

    The sketch led to questions among fans about whether Mulligan’s departure was genuine, but the comedic tone was consistent with Dropout’s style.

    Mulligan has been a leading figure on Dropout since 2018, serving as executive producer and gamemaster for Dimension 20 and appearing on Game Changer and Make Some Noise. 

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  • Novartis’ Kisqali recommended by NICE to treat broad early breast cancer population

    Novartis’ Kisqali recommended by NICE to treat broad early breast cancer population

    Novartis’ Kisqali (ribociclib) has been recommended by the National Institute for Health and Care Excellence (NICE) to treat a broad population of early breast cancer patients.

    The health technology assessment agency has recommended in final draft guidance that the drug be used on the NHS in combination with an aromatase inhibitor as an additional treatment option for patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.

    Patients eligible for the combination will have responded to initial treatments including surgery, but will be at high risk of disease recurrence.

    The decision significantly expands access to the treatment, which was previously available only for patients whose cancer had spread to nearby lymph nodes.

    “We welcome NICE’s recommendation enabling access to [Kisqali] for more patients with early-stage breast cancer. This marks a step forward in expanding treatment options for people diagnosed with HR-positive/HER2-negative early breast cancer,” said Johan Kahlström, president and managing director Novartis UK and Ireland.

    The recommendation follows an approval from Medicines and Healthcare products Regulatory Agency in February and was supported by positive results from the late-stage NATALEE trial.

    In the study, Kisqali used in combination with an aromatase inhibitor reduced invasive disease-free survival events by 25.1% compared to treatment with an aromatase inhibitor alone.

    NICE added that the treatment “has been made cost-effective for the NHS through a confidential discount agreement with Novartis, ensuring patients can access this innovative therapy while maintaining value for the health service”.

    Approximately 56,822 people are diagnosed with breast cancer every year in the UK, and HR-positive/HER2-negative is the most common subtype.

    Despite current treatment options, patients with HR-positive/HER2-negative early breast cancer remain at risk of experiencing disease recurrence in the long term, often as an incurable disease.

    Novartis’ Kisqali is designed to inhibit the CDK4/6 proteins, which play a key role in cancer cell growth and division.

    Helen Knight, director of medicines evaluation at NICE, said: “This is fantastic news for the tens of thousands of patients and their loved ones who are now benefiting from access to cutting edge new treatments.

    “It is also due in no small part to the willingness of companies to engage with us constructively, as in the case with [Kisqali], to ensure the benefits of their treatments are properly presented and appropriately priced.”


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  • Eugenie Bouchard set to retire after leaving ‘profound’ mark on Canadian tennis

    Eugenie Bouchard set to retire after leaving ‘profound’ mark on Canadian tennis



    CNN
     — 

    Eugenie Bouchard, who broke new ground for women’s tennis in Canada, has announced she will retire after this year’s National Bank Open in Montreal.

    The Canadian revealed her decision to step away in an Instagram post Wednesday, saying: “You’ll know when it’s time. For me, it’s now. Ending where it all started: Montreal.”

    The 31-year-old reached the Wimbledon final in 2014, becoming the first woman from her nation to reach a grand slam singles final in the Open Era.

    She also reached the semifinals of both the French Open and Australian Open earlier that year, reaching a career high of world No. 5 in October 2014.

    The year also saw Bouchard win her first and only singles title at Nürnberg, before she qualified for the 2014 WTA Finals.

    “Few athletes have left as profound a mark on Canadian tennis as Genie has throughout her extraordinary career,” said Tennis Canada’s CEO Gavin Ziv in a statement.

    “As one of the very first players to ever be part of the National Tennis Centre presented by Rogers in Montreal, she achieved things that many thought would be impossible for Canadian players.”

    He added: “She’s been and still is an incredible ambassador for our sport and, on behalf of Tennis Canada, I want to thank her for everything she’s done. We wish her continued success in the next chapter of her career.”

    Her career peaked in 2014 and she never quite managed to hit the same heights again, more recently turning her attention to pickleball.

    A distinct turning point in her trajectory as a player was the US Open in 2015, when Bouchard suffered a serious head injury after slipping on a wet locker room floor.

    She suffered a concussion and sued the US Tennis Association (USTA) – a jury found the organization was 75% to blame and Bouchard was 25% to blame.

    Her playing level never seemed to recover from that moment. Bouchard has barely played top level tennis over the last two years and has dropped out of the world’s top 1,000 players.

    Nevertheless, her career has served as inspiration to a new generation of players coming out of Canada.

    “She has been one of the most important figures in the history of our sport in Canada and a trailblazer who redefined what Canadian tennis could be,” National Bank Open’s tournament director Valérie Tétreault said in a statement.

    “We are proud of everything she has done, as a player and role model, and we can’t wait to see her in action one last time at IGA Stadium this summer.”

    The National Bank Open will start on July 26, with Bouchard receiving a wild card to play in the tournament.


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  • Junior Boks name unchanged line-up for Final

    Junior Boks name unchanged line-up for Final

    Lock Riley Norton will once again lead a familiar-looking side that has featured in most of the pool matches, as well as Monday’s semi-final victory over Argentina.

    The unchanged line-up means the bench will again feature a split of six forwards and two backs in what promises to be an epic battle between the two southern hemisphere rugby rivals.

    Junior Bok head coach Kevin Foote said the SA U20s have done well to reach the final and they are excited to face their greatest rivals with a settled side.

    “This has been our settled combination for most of the year, and the team play with great synergy,” said Foote, who admitted it was yet again difficult to leave players out of the match-day squad.

    “Given how well everyone has played, it was such a difficult task to leave anyone out. We are grateful for the absolute selflessness of the players not selected for Saturday’s final, and for how hard they are training to ensure the team is well prepared for New Zealand.

    “We decided to pick six forwards on the bench yet again, as they made a difference in the semi-final against Argentina, and we also learned some valuable lessons when we faced New Zealand in the U20 Rugby Championship in South Africa a few months ago.”

    Saturday’s decider marks the Junior Boks’ first appearance in the final since 2014, and it’s a repeat of the 2012 final in which South Africa beat New Zealand at Newlands in Cape Town.

    The SA U20s have been in rampant form throughout the Championship in Italy, posting comprehensive wins over Australia, defending champions England, and Scotland in the group stage, followed by a hard-earned victory over a gritty Argentina in the semi-finals on Monday evening.

    South Africa’s dynamic pack of forwards has laid an excellent platform for their electric backline to score some eye-catching tries. The Junior Bok halfback pairing of Haashim Pead (scrumhalf) and Vusi Moyo (flyhalf) are amongst the tournament’s leading points scorers.

    Pead has scored six tries in four games – the most by any player so far this year – while also providing numerous assists for teammates. Moyo has racked up 50 points across his four appearances, placing him at the top of the overall points’ scoring chart.

    New Zealand, like South Africa, are unbeaten in the tournament, having topped Pool B before dispatching a dangerous French side in the semi-finals to set up an exciting final showdown with the Junior Boks.

    The World Rugby U20 Championship Final kicks off at 20h30 and will be broadcast live on SuperSport.

    The Junior Springbok team to face New Zealand in Rovigo:

    15 Gilermo Mentoe
    14 Cheswill Jooste
    13 Demitre Erasmus
    12 Albie Bester
    11 Jaco Williams
    10 Vusi Moyo
    9 Haashim Pead

    8 Wandile Mlaba
    7 Bathobele Hlekani
    6 Xola Nyali
    5 JJ Theron
    4 Riley Norton (captain)
    3 Herman Lubbe
    2 Siphosethu Mnebelele
    1 Simphiwe Ngobese

    Replacements:

    16 Jaundré Schoeman
    17 Oliver Reid
    18 Jean Erasmus
    19 Jaco Grobbelaar
    20 Matt Romao
    21 Stephanus Linde
    22 Ceano Everson
    23 Dominic Malgas

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  • ECT More Effective for Depression in Older vs Younger Adults

    ECT More Effective for Depression in Older vs Younger Adults

    TOPLINE:

    Electroconvulsive therapy (ECT) was associated with significantly greater response and remission rates in people aged 85 years or older with depression than in those aged 18-35 years and with fewer treatment-related adverse events (AEs), a new study showed. Individuals in the oldest age group who received ECT also reported fewer hospital readmissions than adults in the same age group who were not treated with ECT.

    METHODOLOGY: 

    • This nationwide Swedish register study included more than 500 oldest-old patients, defined as aged 85-99 years (72% women) treated with ECT for depression. Two propensity score-matched control groups with depression were also included: those aged 18-35 years treated with ECT (n = 522) and those aged 85-96 years not treated with ECT (n = 522).
    • Data were obtained from the Swedish National Quality Register for ECT, Swedish National Patient Register, and Swedish National Cause of Death Register; and rates of response to ECT and remission from depression were calculated.
    • Measures included clinician-reported AEs, prognostic factors including comorbidities and treatment parameters, AEs requiring hospitalization within 1 week from discharge, and deaths within 1 week from discharge.
    • Response was evaluated using the Clinical Global Impression Improvement rating, assessed by treating physicians within 1 week post-ECT. Remission was defined as having a Montgomery-Åsberg Depression Rating Scale-Self Assessment total score of 10 or less post-ECT.

    TAKEAWAY:

    • Compared to younger patients who received ECT, those aged 85 years or older who received the treatment reported significantly higher rates of response (82% vs 67%; odds ratio [OR], 2.4; < .001) and remission (53% vs 27%; OR, 4.2;< .001).
    • Fewer members of the older ECT group experienced AEs during the treatment than the younger ECT group (20% vs 23%), including memory impairment (8% vs 13%).
    • The older ECT group also had significantly fewer hospitalizations within 1 week of discharge than those in the same age group who did not receive ECT (6% vs 14%; OR, 2.7; P < .01). In the older age group, two patients in the ECT group vs nine in the non-ECT group died during or within 1 week of ECT.
    • Severe psychotic depression was the only significant prognostic factor associated with response and remission in the older ECT group.

    IN PRACTICE:

    “The results suggest that ECT could be a viable treatment for depression” among patients aged 85 years or older, the investigators wrote.

    SOURCE:

    This study was led by Tor Arnison, PsyD, PhD, School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden. It was published online on June 19 in The American Journal of Geriatric Psychiatry.

    LIMITATIONS:

    Limited information could be derived from national registers. The assessment of response to ECT relied on clinical evaluation using the Clinical Global Impression Improvement scale, and clinician-reported AEs may have been underreported. Concurrent use of antidepressants in the ECT group and the use of unknown therapies in the non-ECT group may have introduced additional confounding. A selection bias may also have persisted despite propensity matching.

    DISCLOSURES:

    This study was funded by Forskningskommittéen at Region Örebro County and Nyckelfonden at Örebro University Hospital. The investigators reported having no relevant conflicts of interest.

    This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

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  • How Ziad Elsissy’s husband-and-wife LA 2028 dream brought him back from brink of fencing retirement

    How Ziad Elsissy’s husband-and-wife LA 2028 dream brought him back from brink of fencing retirement

    A former basketball player, along with his father and brother, Elsissy used his skills from the court to help him once he pursued fencing. In fact, he practiced many sports before settling on a career with a weapon in hand – his mother signed him up for gymnastics, swimming, and even squash, before he realised that fencing was the path for him.

    “I was always trying to find an excuse to get out to get back to basketball,” he admits. “When I started fencing, I saw how much of an impact it [had] to help me perform better in basketball. Getting me faster, higher jumps, and everything. I started falling in love with the sport and that’s how I continued in fencing.”

    Having learned to adapt from one discipline to another, the sabre fencer now coaches young athletes in New York.

    He says, “I love when my students, before I leave for a tournament, say, ‘Coach Ziad, good luck. You’re going to get this. We’re going to be rooting for you.’ So it’s not only me watching them in tournaments. They watch me, too.

    “Every time I feel a little down, I remember I want to show them that you’re still fighting, that you can always make it work, so it just gives me a boost to fight more.”

    The feeling is mutual – many of the Egyptian’s prodigies flew out to Paris to support their teacher on the Olympic stage.

    Egypt’s Ziad Elsissy and Nouran Gohar aim for LA28 fairytale

    Elsissy’s comeback from his fencing break post-Paris has been so far successful. He finished third on his FIE World Cup return in June, reaching the podium for the second consecutive year in Padua, Italy.

    The Alexandrian followed that up with a continental gold at the African Championships Lagos 2025, taking the men’s team sabre title along with fellow Egypt Olympians Adham Moataz and Mohamed Amer.

    Aiming for a third Olympic Games at LA 2028, Elsissy wants to qualify alongside his wife, Gohar. She has extra motivation as a squash star back home, with the racket sport one of five new events being added to the LA28 programme.

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  • Weather Department Predicts Even More Intense Monsoon Rainfall in Coming Days – ProPakistani

    1. Weather Department Predicts Even More Intense Monsoon Rainfall in Coming Days  ProPakistani
    2. PMD forecasts more thundershower for upper parts as Punjab declares emergency  Business Recorder
    3. Karachi braces for third monsoon spell from Friday  nation.com.pk
    4. Rain, thunderstorms expected in Sindh, including Karachi, on July 19  Aaj English TV
    5. Karachi braces for monsoon spell; drains still choked with garbage Breaking  Independent News Pakistan

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  • Linklaters advises Ontario Teachers’ Pension Plan Board on its acquisition of DONTE GROUP

    Linklaters advises Ontario Teachers’ Pension Plan Board on its acquisition of DONTE GROUP

    Linklaters has advised global investor Ontario Teachers’ Pension Plan Board (Ontario Teachers’), on its definitive agreement with Advent, to acquire 100% of DONTE GROUP, the Spanish oral healthcare group, alongside its management team. The deal values the company at more than €1bn.

    The investment Linklaters facilitated reflects Ontario Teachers’ conviction in DONTE GROUP as a sector-leading platform with high quality service and brands, a first-class management team and a significant runway for growth, including through organic expansion, new clinic openings and selective acquisitions. Through this deal Ontario Teachers’ offers the DONTE GROUP access to long-term, flexible capital and considerable expertise in building and growing specialist dental and healthcare services companies in the USA, Europe and Asia. DONTE GROUP will become part of Ontario Teachers’ CAD$6bn global healthcare portfolio, which includes Heartland Dental, PhyNet, Veonet and NVISION.

    The Linklaters cross-border and multi practice team was led by Corporate Partner Esteban Arza and Corporate Counsel Elena Rodriguez in Madrid, and Corporate Partners Ben Rodham and Genna Marten with Leveraged Finance Partner Oliver Sceales from London. The expert practice areas included Corporate, Private Equity, Banking, Tax, Employment & Incentives, TMT/IP and AFIG.

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  • Mercedes-Benz Will Let You Show Your Face In Online Meetings While Driving

    Mercedes-Benz Will Let You Show Your Face In Online Meetings While Driving

    • Mercedes-Benz will allow drivers to use the car’s built-in selfie camera with Microsoft Teams while driving.
    • Teams is an online conference software used by many companies.
    • The German marque says its cars can become a third office space, after the actual office and the home office. But does anybody really want that?

    Eight-year-old me would think that we would have flying cars by now, but that still hasn’t happened yet. Instead, in the year 2025, the car is becoming yet another place where we can have online work meetings, even while driving.

    That’s all thanks to Mercedes-Benz, which will soon allow drivers of some of its cars to use the built-in selfie camera to join Microsoft Teams calls while on the go. The automaker says that the use of the camera abides by the laws of each country and has been approved for use on the move.

    When the vehicle is stationary, the driver can see the video stream, but when the car sets off, the stream shuts off automatically to increase safety and minimize distraction. Meanwhile, the other meeting participants can still see the video feed from the car, but the camera can also be turned off for an audio-only experience.

    Here’s Mercedes-Benz CEO Ola Kallenius showcasing the feature during a Teams video call with Microsoft’s CEO, Satya Nadella:

    The new feature, which is part of a wider collaboration with Microsoft, was showcased on the new CLA electric sedan which is running the MB.OS infotainment system. Besides enabling in-car camera use while driving in Teams, compatible Mercedes-Benz models will also get Microsoft Intune integration, as well as the software giant’s 360 Copilot AI assistant. The former enables a secure workplace that separates private data from business data, while the latter can summarize emails and manage daily tasks through voice commands.

    “Through our industry-leading collaboration with Microsoft, we are making it even easier for our customers to stay productive while on the move,” said Ola Kallenius, Chairman of the Board of Management of Mercedes-Benz Group AG. “By integrating the latest Microsoft workspace tools, such as Microsoft Teams, directly into our new operating system, MB.OS, we’ve created an intuitive and safe user experience that boosts efficiency and reduces distractions at the same time.”

    With all these new features, the German marque claims its cars have the potential to transform into “a third workspace, complementing the office and the home office.” I don’t know about you, but that sounds like one too many workplaces.

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  • British and Irish Lions 2025: Scottish centres ready to roll

    British and Irish Lions 2025: Scottish centres ready to roll

    Jones, 31, landed in Scottish rugby with an almighty bang – power, pace, incredible lines of running, an unerring try-scoring record. Ten in his first 14 Tests – three against Australia, four against England. Unstoppable.

    “When he first came through he would just wriggle out of tackles,” says Townsend. “He knew exactly what he needed to do either to get into space or to force that defender to defend him, which opened up the space for someone else.”

    Everything was easy, until it wasn’t. He sailed through 2016-17 and 2017-18. A World Cup beckoned in 2019 in Japan. A Lions tour looked likely in 2021. None of it happened. There were chunks of time when he couldn’t even get a start for Glasgow, when he wanted out and when he was “at peace” with the end of his international career.

    In the beginning, they called him ‘Humble Huw’, a wind-up based on his fantastic confidence. Humble ceased to exist along the way. Injuries came for him, a loss of form hit deeply, an absence of self-belief brought him to the brink. “I’d decided that was it, my international career was over,” he said.

    His defensive game was ripped apart, he got an unfair reputation of being indifferent, only keen on the big games for Scotland rather than coalface nights with Glasgow.

    The opposite was the case, but that was him now. Branded. He wanted to talk to his Glasgow coach, Dave Rennie, but they never clicked. Jones had no confidence around him – nervous and sweating, he tried to articulate his frustrations but couldn’t really get the words out right. He fell into a slump that nobody saw coming. Him, least of all.

    So he missed out on the 2019 World Cup and didn’t play for Scotland for close on two years. The comeback was launched in a season with Harlequins, when he started to rebuild.

    “Those experiences would have hurt,” says Townsend. “They’ve made him into the player he is today. You can react in two ways there. You can not work on the things you know you have to work on to get back to the level you’re capable of playing, or you can say it’s not for me, or it was the coach’s fault, or whatever.

    “At times like that, you just hope that players do make it. The feedback we were giving him was that he had to do more on the defensive side of it. He had a nine out of 10 attack and he needed to get his defence up to seven or eight out of 10 and he’s done that. He’s gone beyond it. We see his defence at the same level as his attack now. He’s become a complete player.

    “We’ve always wanted him to back himself more and get on the ball more because his running lines are world class.

    “That little short ball that he’s been getting so far on the Lions tour when he’s played with Sione, that’s a lot to do with him being in the right place at the right time for Sione to give him that pass when the defence has made one or two decisions and they’ve drifted out and he’s through the hole. It’s almost a total package in attack.

    “He reminds me of Alan Tait from my time. He was really good at running those lines and scored a lot of tries. It’s a different game now, but they’re very similar.”

    Joint second try-scorer with three, third for line breaks and fourth for metres gained, Jones is having a big tour. The biggest examination has yet to come, though.

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