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  • Research reveals secret behind scarless healing in the mouth

    Research reveals secret behind scarless healing in the mouth

    Your mouth is a magician. Bite the inside of your cheek, and the wound may vanish without a trace in a couple of days. A preclinical study co-led by Cedars-Sinai, Stanford Medicine and the University of California, San Francisco (UCSF), has discovered one secret of this disappearing act. The findings, if confirmed in humans, could one day lead to treatments that enable rapid, scarless recovery from skin wounds on other parts of the body.

    The study was published in the peer-reviewed journal Science Translational Medicine.

    Our research began with two questions: Why does your mouth heal so much better than your skin? And if we figure that out, can we use that information therapeutically?”


    Ophir Klein MD, PhD, executive vice dean of Children’s Health at Cedars-Sinai, executive director of Cedars-Sinai Guerin Children’s, the David and Meredith Kaplan Distinguished Chair in Children’s Health and co-corresponding author of the study

    The need for therapies is clear. Wounds to the lining of the mouth typically disappear in one to three days. But skin wounds may take nearly three times as long to heal and can leave unsightly scars.

    “Unfortunately, current treatments do not adequately resolve or prevent scarring because we do not fully understand the mechanism,” Klein said. “Our research helps fill in that knowledge gap.”

    In the study, investigators analyzed tissue samples from the lining of the mouth, known as the oral mucosa, and the facial skin of laboratory mice. In the oral mucosa, they found a signaling pathway between cells, involving a protein called GAS6 and an enzyme called AXL, which blocks a different cellular pathway, known as FAK, that promotes scarring.

    When the investigators inhibited the AXL enzyme in the laboratory mice, the oral mucosa wounds’ healing worsened, making them more like skin wounds. When AXL was stimulated in the skin wounds, they healed much like oral mucosa wounds, regenerating tissue more efficiently.

    “This data shows that the GAS6-AXL pathway is potentially important for scarless healing in the mouth and that manipulating it may help reduce skin scars as well,” Klein said.

    The next steps are to further determine how these preclinical findings apply to humans and to develop therapies to improve healing of skin wounds, according to Michael Longaker, MD, the Dean P. and Louise Mitchell Professor in the School of Medicine at Stanford University, and the study’s co-corresponding author.

    “Further clinical studies should be performed to assess the nature of the relationship between AXL and scarring in humans,” Longaker said.

    Source:

    Cedars-Sinai Medical Center

    Journal reference:

    Griffin, M. F., et al. (2025) Growth arrest specific–6 and angiotoxin receptor–like signaling drive oral regenerative wound repair. Science Translational Medicine. doi.org/10.1126/scitranslmed.adk2101.

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  • Punjab CM expresses Govt's resolve to make province plastic-free – RADIO PAKISTAN

    1. Punjab CM expresses Govt’s resolve to make province plastic-free  RADIO PAKISTAN
    2. ‘Green credit’ scheme for recycling plastic bottles launched in Lahore  The Express Tribune
    3. Punjab launches ‘Plastic-Free Punjab Pledge’ campaign  nation.com.pk
    4. Breaking the plastic habit  Pakistan Today
    5. CM Maryam launches Pakistan’s first incentive-based environmental programme  Associated Press of Pakistan

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  • Transport connectivity paves brighter way for more trade among SCO members-Xinhua

    TIANJIN, July 3 (Xinhua) — Since late June, 29 drivers from Kazakhstan have been participating in immersive training sessions in north China’s Tianjin Municipality to master light-rail driving skills.

    Held by Tianjin Rail Transit, the three-month program will provide technical solutions for equipment system installation and commissioning, extreme weather response, equipment procurement, and renovation for a light-rail line in Astana, the capital of Kazakhstan.

    Rather than copying China’s experience, the team studied Astana’s local conditions and customized training programs and materials to meet its specific needs, said Wang Qingyong, a consulting manager with Tianjin Rail Transit.

    “To enhance connectivity, we not only need to deepen infrastructure links but also promote closer ties between the peoples,” said Wu Bingjun, chairman of the Tianjin company.

    Transportation has always been a leading area for cooperation among the Shanghai Cooperation Organization (SCO) countries. From Tuesday to Wednesday, the Senior Officials’ Meeting of the Global Sustainable Transport Forum and the 12th meeting of the SCO Ministers of Transport were held in Tianjin, where officials from different countries provided new insights into promoting regional transport connectivity.

    Sohail Khan, deputy secretary-general of the SCO, said at the forum that “we aim to develop a sustainable, efficient transportation system that delivers high-quality services while incorporating cutting-edge technologies contributed by all participating countries, including China.”

    Multiple transportation corridors have opened shipping channels and added trade routes for SCO countries, serving as new engines for industrial and economic development.

    On June 30, Beijing’s first cross-Caspian Sea China-Europe freight service to Baku, the capital of Azerbaijan, was launched. The route employs a rail-sea-rail multimodal transport system, covering more than 8,000 km and reducing the transit time from approximately 50 days to around 15.

    “The launch of this train has established a more convenient and efficient international logistics channel, and will significantly promote trade between China and other countries and regions like Azerbaijan,” said Wang Dong with China Railway Beijing Group’s logistics center.

    Last year, Azerbaijan received over 350 trains from Chinese cities as part of the China-Europe freight train service. This service continuously drives the upgrade and expansion of trade corridors, said Fariz Aliyev, head of the transport policy department at Azerbaijan’s Ministry of Digital Development and Transport.

    The China-Europe Railway Express exemplifies the growing transport connectivity between China and the SCO member states. According to the Ministry of Transport, in 2024, a total of 19,000 China Railway Express trains passed through SCO countries and regions, representing a 10.7 percent year-on-year increase, as the regional connectivity network becomes more intertwined.

    Li Yang, China’s vice minister of transport, said that China will continue to engage with the world and keep up with the times, promoting global transport cooperation, offering new opportunities through its development, and continuously fostering global transport collaboration based on mutual consultation, joint construction, and shared benefits.

    In 2024, trade between China and SCO member states, observers and dialogue partners reached a record 890 billion U.S. dollars, and the total stock of various investments has exceeded 140 billion dollars, with the value of newly signed engineering contracts surpassing 1 trillion dollars and a cumulative turnover of over 680 billion dollars.

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  • D-PAK™ cartons have smaller carbon footprint than plastic pouches for laundry detergent

    D-PAK™ cartons have smaller carbon footprint than plastic pouches for laundry detergent

    Landmark Life Cycle Assessment (LCA) shows cartons have significantly smaller carbon footprint than plastic pouches for laundry detergent

    Elopak has today published the findings of a Life Cycle Assessment (LCA) study comparing the company’s D-PAK™ cartons with LDPE pouches for use as refill packaging for household products.

    The study, commissioned by Elopak and undertaken by Anthesis, compared the environmental impact of using the D-PAK™ carton as a refill pack for a bottle of laundry detergent versus an LDPE plastic pouch in the EU market. The study found that cartons significantly outperform pouches across several categories, notably global warming, CO2 footprint, resource scarcity impact, and plastic reduction.

    Key findings include:
    • Global warming: Using a D-PAK™ carton as refill packaging, results in a 24% lower impact on global warming than a 1L pouch, rising to 28% for a 1.8L pouch. The carton still maintains an advantage even when LDPE pouches are made with 50% and 100% recycled material.

    • Resource scarcity impact: Using a D-PAK™ carton as a refill solution is associated with a 33% lower resource scarcity impact than a 1L pouch. This increases to 38% for a 1.8L pouch.

    • Plastic reduction: Using D-PAK™ cartons as a refill system uses 44% less plastic than LDPE pouches. A D-PAK™ carton contains 9.0g of plastic, compared to 20.1g of plastic in an LDPE pouch and 76.7g in a polypropylene bottle.

    Commenting on the findings Elopak’s Senior Director for Sustainability Emilie Olderskog stated, “We are delighted to be able to share these findings, which show that Elopak cartons are a significantly more sustainable packaging solution for laundry detergent than common refill alternatives like pouches.”

    “At Elopak we are committed to delivering more sustainable packaging options for our customers and their consumers. This LCA now demonstrates that by choosing fiber-based cartons, home and personal care brands can offer shoppers similar sustainability advantages as Elopak customers in the food and drink sector. This gives consumers a more environmentally responsible option right across the supermarket aisles,” she continued.

    Previous LCAs have demonstrated the sustainability credentials of cartons compared to plastic bottles for products such as milk and juice. A 2020 meta-analysis of LCA studies commissioned by the Alliance for Beverage Cartons and the Environment (ACE – now the Food and Beverage Carton Alliance) found that beverage cartons had an average carbon footprint of 83g CO2/L, compared to 156g CO2/L for PET bottles, 430g CO2/L for single-use glass bottles, and 100g CO2 /litre for reusable glass bottles.

    Having relaunched the D-PAK™ carton in 2021, Elopak has helped well-known brands including Sainsbury’s, Morrisons, Omo and Paperdent to adopt more sustainable packaging solutions for home and personal care products, ranging from laundry detergent to fabric softener, mouthwash and even wiper fluid.

    These latest LCA findings follow research published by Elopak in 2024, which demonstrated that consumers in the UK and Germany are keen to purchase refills of several household goods in cartons, including hand soap, washing up liquid and floor cleaner. 64% of those surveyed said they would be happy to purchase fabric softener in a carton, along with 61% who said they would buy detergent and 59% who would buy floor cleaner if it came in a carton refill pack.

    Following the launch of its strategy, ‘Repackaging tomorrow’, in September 2024, Elopak is working to leverage the plastic replacement shift as a key pillar of its growth plans. This includes bringing fiber-based packaging to new markets and product segments as more brands and consumers look for ways to reduce their reliance on plastics.

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  • Israel kills over 139, injures 487 in Gaza today

    Israel kills over 139, injures 487 in Gaza today

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    The death toll in Gaza has continued to rise, with at least 139 Palestinians killed and 487 wounded in Israeli airstrikes over the past 24 hours, according to the territory’s Health Ministry.

    The ministry also reported that three more bodies were recovered from beneath rubble caused by earlier attacks.

    The latest count includes 223 deaths newly confirmed by a judicial committee reviewing reports of missing persons.

    Among those killed in the past day, 39 were aid seekers who arrived at hospitals, with over 210 others injured. The Health Ministry said the total number of aid seekers killed since the start of the conflict has now reached 640.

    One of the deadliest strikes occurred in the al-Mawasi area, west of Khan Younis, where a tent was hit, killing 13 people — among them a couple and their four children.

    Mourners react during the funeral of Palestinians, who, according to Gaza’s health ministry, were killed in an overnight Israeli strike on a tent, at Nasser Hospital in Khan Younis, southern Gaza Strip on July 3, 2025. —Reuters

    Another attack struck the Mustafa Hafez School, which was sheltering displaced residents in western Gaza City, resulting in 11 fatalities.

    A Palestinian girl looks at the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    A Palestinian girl looks at the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    Read: At least 27 killed in Gaza City after fresh evacuation orders

    An air strike near the Nabulsi Roundabout, also west of Gaza City, left at least six people dead and around 100 injured, many of whom were reportedly waiting for aid.

    Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    Palestinians inspect the damage at a school sheltering displaced people, following an overnight Israeli airstrike, in Gaza City, July 3, 2025. Photo: REUTERS

    UNRWA calls for control of Gaza aid distribution

    The United Nations Relief and Works Agency for Palestine Refugees (UNRWA) has urged an independent investigation into the deaths and injuries of Palestinians attempting to access food via the current US- and Israeli-supported aid delivery system in Gaza.

    In a statement posted on X, the agency accused Israeli forces of opening fire on civilians and of people being fatally crushed by aid trucks.

    “Lift the siege now,” UNRWA said. “Aid delivery must be safe, dignified and accessible to all. Let the UN, including UNRWA, do the work.”

    UN rights expert calls for global sanctions on Israel

    UN special rapporteur Francesca Albanese has urged states to impose a full arms embargo and sever trade and financial ties with Israel, which she accused of carrying out “one of the cruellest genocides in modern history” in Gaza.

    Speaking before the UN Human Rights Council, Albanese presented a report naming more than 60 companies allegedly involved in supporting Israeli settlements and military operations in Gaza.

    “This is not just a list; it’s a system,” she said. “We must reverse the tide.” She called on countries to suspend trade agreements and hold corporations accountable for violations of international law.

    Read more: At least 27 killed in Gaza City after fresh evacuation orders

    UN expert accuses Israel of weapon-testing in Gaza amid 85,000-tonne explosive devastation

    In a report presented to the UN Human Rights Council, Francesca Albanese, the Special Rapporteur on human rights in the occupied Palestinian territories, said arms manufacturers had made near-record profits by supplying Israel with cutting-edge technology used to unleash 85,000 tonnes of explosives — six times the power of the Hiroshima bomb — on the Gaza Strip.

    Albanese said the destruction in Gaza had coincided with gains on the Tel Aviv Stock Exchange since October 2023. “One people enriched, one people erased,” she told the council.

    She alleged that the conflict had turned Palestine into a live-testing zone for “new weapons, customised surveillance, lethal drones and radar systems,” calling Gaza “an ideal laboratory for the Israeli military-industrial complex.”

    The report named 48 companies — including arms manufacturers, banks, tech firms, energy conglomerates and academic institutions — allegedly tied to what Albanese described as an “economy of occupation.”

    “From data systems that surveil Palestinians to fossil fuels that power illegal settlements, corporate complicity runs deep,” she said.

    Citing international law, Albanese said even indirect ties to these systems carry legal responsibility. She urged states to impose a full arms embargo on Israel, suspend all trade and investment agreements, and ensure companies involved face legal consequences.

    “Member states must act. The time for bold steps is now,” she said.

    Israel’s government did not attend the session and has previously dismissed Albanese’s findings as “legally unfounded” and an abuse of her UN mandate.

    Saudi Arabia condemns Israeli minister’s call for sovereignty over occupied West Bank

    Saudi Arabia has strongly criticised recent statements by Israeli ministers advocating full sovereignty over the occupied West Bank, according to Asharq Al-Awsat.

    In a statement issued by the Ministry of Foreign Affairs, the Kingdom said it “condemns and denounces” the remarks made by Israeli officials, reaffirming its stance against any moves to assert Israeli control over Palestinian territories.

    Hamas reviews 60-day Gaza ceasefire proposal

    Hamas said on Wednesday it was studying what US President Donald Trump called a “final” ceasefire proposal for Gaza but that Israel must pull out of the enclave, and Israeli leader Benjamin Netanyahu said Hamas would be eliminated.

    Trump said on Tuesday that Israel had agreed to the conditions needed to finalise a 60-day ceasefire with Hamas after a meeting between his representatives and Israeli officials.

    In a statement, the Palestinian group said it was studying new ceasefire offers received from mediators Egypt and Qatar but that it aimed to reach an agreement that would ensure an end to the war and an Israeli pullout from Gaza.

    Meanwhile, Netanyahu called for the elimination of Hamas in his first public remarks since Trump’s announcement.

    “There will not be a Hamas. There will not be a ‘Hamastan’. We’re not going back to that. It’s over,” Netanyahu told a meeting hosted by the Trans-Israel pipeline.

    The two sides’ statements reiterated long-held positions, giving no clues as to whether or how a compromise agreement could be reached.

    Israel’s war on Gaza

    The Israeli army has launched a brutal offensive against Gaza since October 2023, killing at least 57,012 Palestinians, including 134,592 children. More than 111,588 people have been injured, and over 14,222 are missing and presumed dead.

    Last November, the International Criminal Court issued arrest warrants for Israeli Prime Minister Benjamin Netanyahu and his former Defense Minister Yoav Gallant for war crimes and crimes against humanity in Gaza.

    Israel also faces a genocide case at the International Court of Justice for its war on the enclave.

     


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  • Nearly 1,000 Britons adopt permanently shorter working week after trial | Four-day week

    Nearly 1,000 Britons adopt permanently shorter working week after trial | Four-day week

    Nearly 1,000 British workers will adopt a permanently shorter working week, after the latest trial of a four-day week and similar changes to traditional working patterns.

    All 17 British businesses in a six-month trial of the four-day week said they would continue with an arrangement consisting of either four days a week or nine days a fortnight. All the employees remained on their full salary.

    The trial was organised by the 4 Day Week Foundation, a group campaigning for more businesses to take up shorter working weeks.

    The latest test follows a larger six-month pilot in 2022, involving almost 3,000 employees, which ended in 56 of 61 companies cutting down their hours from a five-day working week.

    The 4 Day Week Foundation is hoping to build on the shift around the end of the 19th century and the start of the 20th century, when campaigns led by trade unions gave birth to the two-day weekend. The previous norm for many people in Britain and other traditionally Christian countries had been a six-day working week, with time off only on Sundays.

    Campaigners and some economists argue that the four-day week can offer benefits to workers such as less strain on their mental health, and to businesses, including more motivated staff and easier recruitment and retention.

    Researchers at Boston College, a US university, said that the findings from the latest trial were “extremely positive” for workers. They found that 62% of workers reported that they experienced less burnout during the trial, according to a poll of 89 people. Forty-five percent of those polled said they felt “more satisfied with life”.

    The 4 Day Week Foundation has run successive trials to gather data and demonstrate how companies can make the switch. In January, the foundation said more than 5,000 people from a previous wave had started the year permanently working a four-day week.

    Companies involved in the latest trial, which started in November, included charities and professional services firms, with the number of employees at each employer ranging between five and 400. They included the British Society for Immunology and Crate Brewery in Hackney, east London,

    Campaigners hope that they can build momentum for the change. The 4 Day Week Foundation said the government should create a working time council to coordinate policy between business and industry leaders as well as trade unions.

    The concept of the four-day week faced strong opposition from the previous Conservative government. Labour ministers have previously expressed more support for the concept, although they have offered little in the way of formal recognition since coming to power in 2024.

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    In 2023, Angela Rayner, who has since become deputy prime minister, said: “If you can deliver within a four-day working week, then why not. I think people will cotton on to the fact that it’s really good, if it works for their sector and boosts productivity.”

    The small web software company BrandPipe said that the latest trial had been a success for the business, coinciding with increased sales. Geoff Slaughter, the BrandPipe chief executive, said: “The trial’s been an overwhelming success because it has been the launchpad for us to consider what constitutes efficiency, and financial performance is double what it was before.”

    Slaughter added: “If we’re going to see it rolled out more substantially across different sectors, there should be incentives for early adopters, because we’re creating the blueprint for the future.”

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  • A unique mission to both Uranus and Neptune could launch in 2034

    A unique mission to both Uranus and Neptune could launch in 2034

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    Travel the universe with Dr. Ethan Siegel as he answers the biggest questions of all.

    Here in the 21st century, we’ve learned so much more about our Universe than we could have imagined even just a single generation ago. Back in 1990, we hadn’t discovered any planets orbiting stars beyond our own Solar System; today, we’re closing in on 6000 confirmed exoplanets. Back then, the only prospects for life beyond Earth were potential microbes on planets or moons in our backyard; now, we know of scores of stars that may host living worlds around them. And a number of missions that didn’t just image the other planets and/or moons from afar, but orbited, probed, or even landed on them to explore them have occurred, teaching us about the complex chemistry and composition of worlds that are wildly different from our own.

    Over all the time that’s passed since the Voyager missions, however, there are two major planets in our Solar System that remain unexplored from up close — unvisited — since the late 1980s, when Voyager 2 flew by them. Uranus and Neptune, the smallest gas giants in the Solar System and the closest analogues we have to the most common type of exoplanet found thus far: the mini-Neptune. In fact, in recent months, many have speculated that some of these mini-Neptunes may be potentially inhabited, advancing the science case for studying the worlds we do have that are like them, Uranus and Neptune, up close.

    Here in the JWST era, we’ve seen these worlds better than ever since Voyager 2’s flyby, but haven’t designed or flown a mission to go visit them in all the time since. 2034 will be the perfect opportunity to change that, however. Here’s the science of why.

    Pioneer 11, following in the footsteps of Pioneer 10, actually flew through Jupiter’s lunar system, then used Jupiter’s gravity as an assist maneuver to take it to Saturn. While exploring the Saturnian system, a planetary science first, it discovered and then nearly collided with Saturn’s moon Epimetheus, missing it by an estimated ~4000 km. Newtonian gravity, alone, was capable of calculating these maneuvers.

    Credit: Phoenix7777/Wikimedia Commons

    The Solar System is a complicated — but thankfully, regular — place. The best way to get to the outer Solar System, which is to say, any planet beyond Jupiter, is to use Jupiter itself to help you get there. In physics, whenever you have a small object (like a spacecraft) fly by a massive, stationary one (like a star or planet), the gravitational force can change its velocity tremendously, but its speed must remain the same.

    But if there’s a third object that’s gravitationally important, that story changes slightly, and in a way that’s particularly relevant for reaching the outer Solar System. A spacecraft flying by, say, a planet that’s bound to the Sun, can gain-or-lose speed by stealing-or-giving-up momentum to the planet/Sun system. The massive planet doesn’t care, but the spacecraft can get a boost (or a deceleration) depending on its trajectory.

    This type of maneuver is known as a gravity assist, and it was essential in getting both Voyager 1 and Voyager 2 on their way out of the Solar System, and more recently, in getting New Horizons to fly by Pluto. Even though Uranus and Neptune have spectacularly long orbital periods of 84 and 165 years, respectively, the mission windows for getting to them recur every 12 years or so: every time Jupiter completes an orbit and lines up with Earth, Uranus, and Neptune once again.

    By either passing inside of a planet’s orbit while plunging toward the Sun (as shown), or outside of a planet’s orbit while moving away from the Sun, a spacecraft can get de-boosted via the gravity assist/gravitational slingshot mechanism. The two opposite maneuvers would increase the spacecraft’s speed, resulting in a velocity boost, rather than a de-boost. Both are used in navigating spacecraft across the Solar System.

    Credit: Y. Guo et al., Acta Astronautica, 2021

    A spacecraft launched from Earth typically flies by some of the inner planets a few times in preparation for a gravity assist from Jupiter. A spacecraft flying by a planet can get proverbially slingshotted — gravitational slingshot is a word for a gravity assist that boosts it — to greater speeds and energies. If we wanted to, the alignments are right that we could launch a mission to Neptune today. Uranus, being closer, is even easier to get to.

    Bac in 2009, the Argo mission was proposed: it would fly-by Jupiter, Saturn, Neptune, and Kuiper belt objects, with a launch window lasting from 2015 to 2019. However, performing flyby missions are relatively easy, because you don’t have to slow the spacecraft down relative to the planet you’re targeting.

    Inserting it into orbit around a world is harder, but it’s also far more rewarding. Instead of a single pass, an orbiter can get you whole-world coverage, multiple times, over long periods of time. You can see changes in the atmosphere of a world, and examine it continuously in a wide variety of wavelengths invisible to the human eye. You can find new moons, new rings, and new phenomena that you never expected. You can even send down a lander or probe to the planet or one of its moons. All of that and more already happened around Saturn with the Cassini mission, which came to a planned end in 2017.

    A 2012 (top) and a 2016 (bottom) image of Saturn’s north pole, both taken with the Cassini wide-angle camera. The difference in color is due to changes in the chemical composition of Saturn’s atmosphere, as induced by direct photochemical changes.

    Credit: NASA/JPL-Caltech/Space Science Institute/Hampton University

    Cassini didn’t just learn about the physical and atmospheric properties of Saturn, although it did that spectacularly. It didn’t just image and learn about the rings, although it did that too. What’s most incredible is that we observed changes and transient events that we never would have predicted.

    • Saturn exhibited seasonal changes, which corresponded to chemical and color changes around its poles.
    • A colossal storm developed on Saturn, encircling the planet and lasting for many months.
    • Saturn’s rings were found to have intense vertical structures and to change over time; they’re dynamic and not static, and provide a laboratory to teach us about planet-and-moon formation.
    • And, with its data, we solved old problems and discovered new mysteries about its moons Iapetus, Titan, and Enceladus, among others.

    In other words, we discovered all that we discovered about Saturn — along with its system of moons and rings — because we dared to go there with a high-tech, radiation-hard dedicated orbiter mission, and because we equipped it with a suite of instruments that could probe so much about this planet and the moons it encountered. It was loaded with discovery potential, and that enabled it to find out what was previously unknown about the Saturnian system: to the benefit of all of humanity.

    Over a period of 8 months, the largest storm in the Solar System raged, encircling the entire gas giant world. The storm itself was large enough that it was capable of fitting as many as 10-to-12 Earths inside. Cassini, although it wasn’t expecting this to occur, was equipped with instrument technology that was more than sufficient to discover and study this unprecedented feature.

    Credit: NASA/JPL-Caltech/Space Science Institute

    Without a doubt, there’s no question that we absolutely want to do the analogous things for Uranus and Neptune. Many orbiting missions to Uranus and Neptune have been proposed and made it quite far in the mission submission process, but none have actually been slated to be built or fly. NASA, the ESA, JPL, and the UK have all proposed Uranus orbiters that are still in the running, but no one knows what the future holds.

    One of the major, flagship-class missions proposed to NASA’s planetary science decadal survey in 2011 was a Uranus probe and orbiter; it was ranked #3, but in the most recent planetary science decadal, it was ranked as the highest-priority planetary flagship mission. Uranus, as well as its outer neighbor, Neptune, are both suspected (based on modeling and Voyager 2 data) to have enormous liquid oceans beneath their atmospheres, which an orbiter should be able to discover for certain. The mission could also include an atmospheric probe, with the potential to measure cloud-forming molecules, heat distribution, and how wind speed changes with depth.

    In all the time since Voyager 2, which flew by Uranus in 1986 and Neptune in 1989, we’ve only studied these planets from afar. The most recent views that we have of these worlds, however, are indeed the most spectacular ones obtained in all the time since: visions of Uranus and Neptune from the James Webb Space Telescope.

    Numerous features surrounding Neptune, as identified in the JWST images. All 7 of Neptune’s inner moons can be seen here, along with the two main rings and two dusty, more diffuse rings seen here. Triton, although captured by JWST, is too far away to be a part of this cropped JWST image.

    Credit: NASA, ESA, CSA, and STScI, annotations by H. Hammel and E. Siegel

    JWST’s views of Uranus and Neptune showed us features we only ever had hints of from Voyager 2 data, with Uranus in particular making a very interesting test case. You see, Neptune got its JWST close-up more than halfway through 2022, and so many features were revealed in a visually stunning way. They include:

    • Neptune’s disk,
    • its highly reflective clouds,
    • all seven of its known inner moons,
    • its four major rings (Adams, Lassell, Le Verrier, and Galle),
    • and its highly reflective largest moon, Triton,

    in our best view of all of these features since 1989’s visit.

    Uranus, on the other hand, has already been viewed twice by JWST, with its second, superior looking coming in late 2023. Uranus is a bit special: of all the planets in the Solar System, it’s the only one that rotates primarily on its side, with its rotational axis oriented at a nearly 90° tilt (at around 98°) to the “vertical” rotation of the other planets. With an 84 year orbit around the Sun, this means that every 21 years, it undergoes transitions from Uranian solstice, where one pole points directly at the Sun and the other point directly away, to Uranian equinox, where each part of that world receives equal night and daylight, and then back again in the next 21 years.

    seasons of uranus equinox solstice dates

    When Voyager 2 flew by Uranus in 1986, the planet was near solstice, with its southern hemisphere facing the Sun and its northern hemisphere facing away. In 2007, Uranus achieved equinox, and now heads toward its next 2028 solstice. It won’t reach equinox again until 2049, when JWST will likely be out of fuel and defunct, but when an orbiter mission could be present.

    Credit: M. Showalter & M. Gordon, SETI Institute; modification by E. Siegel

    When Voyager 2 flew by Uranus in 1986, it was at Uranian solstice. It appeared bland and featureless due to the Sun heating one of its poles, not the entire, rapidly rotating planet. Then, in 2007, Uranus was at equinox, displaying rapidly evolving atmospheric features and auroral activity visible remotely: from Hubble and from the world’s flagship ground-based telescopes. Now, however, it’s approaching Uranian solstice once again, which it will reach in 2028. This time, the opposite pole from 1986 is starting to face the Sun, and the planet, again, overall, will soon become largely featureless in appearance.

    Therefore, when JWST takes its looks at Uranus, we’re seeing it as it’s finishing its transition from equinox-to-solstice, illuminating one pole, preferentially, but only obliquely: at an angle. What JWST saw was spectacular, and again, unprecedented since Voyager 2.

    • Uranus currently displays a polar cap, although those high-altitude ices and clouds are beginning to dissipate due to their continuous exposure to sunlight.
    • Surrounding that cap is a less dense region, where the cap is evaporating.
    • Dark lanes indicate further evidence of evaporation, punctuated by bright spots: Uranian storms.
    • Then the inner Zeta (ζ) ring, followed by the α and β rings, the η ring, the thin δ, and the thick ε ring.
    • After that, nine of Uranus’s prominent, inner moons appear: Bianca (#3) through Puck (#12), excluding only the too-small Cupid.
    • And finally, the five major moons Miranda, Ariel, Umbriel, Titania, and Oberon can be seen.

    A cluster of galaxies with a blue star in the middle, captured by the James Webb Space Telescope (JWST).

    The five largest moons of Uranus, in order from the innermost to the outermost, are Miranda, Ariel, Umbriel, Titania, and Oberon, with the latter two being the largest and first-discovered among Uranus’s moons. All of these moons and the innermost one rotate within a single degree of Uranus’s orbital plane except for Miranda, which is inclined by 4.3 degrees.

    Credit: NASA, ESA, CSA, STScI

    While JWST can continue to image Uranus for approximately the next 20 years or so from afar, the ideal goal is to go there, in situ, during the opposite conditions from when we were last there. We went during solstice last time, with Voyager 2, and therefore the next time, ideally, we’ll go to coincide with equinox. And it just so happens that the travel-time to Uranus, to enter an easily-insertable orbit around it with the appropriate gravity assists on the way there, involves about a 13 year travel-time. Under ideal conditions, after leaving Earth, you’d get a gravity assist from Jupiter, and then you fly past Uranus, dropping off (and inserting) an orbiter and possibly an atmospheric probe as well, and then you’d continue on, assisted by Uranus’s gravity, to Neptune, where you’d then have a second orbiter and possibly atmospheric probe, too.

    Most orbiters that have been proposed, with or without probes, typically are slated for about 5 year science lifetimes. What should give us all tremendous hope for a future mission is that there will be a launch window to reach both worlds with a single mission, Uranus and Neptune alike, that align at once: in 2034. That’s when the conceptual ODINUS mission would send twin orbiters to both Uranus and Neptune simultaneously: arriving at Uranus in 2047, just two years before the next (2049) Uranian equinox, and then allowing an orbiter to arrive at Neptune about three years later: in 2050. The ODINUS mission itself, as originally proposed, would be a spectacular, joint venture between NASA and the ESA.

    Uranus

    Uranus and its five major moons are depicted here in this montage of images acquired by the Voyager 2 mission in 1986. The five moons, from largest to smallest, are Ariel, Miranda, Titania, Oberon, and Umbriel. Puck, the 6th largest moon, is interior to all of them, and appears in the first and second JWST images of Uranus alongside these five. An orbiter and atmospheric probe, combined, could revolutionize our knowledge of this world.

    Credit: NASA/JPL

    In order to get the maximum amount of science possible out of the mission, you’d have to design your instruments properly. The orbiter would require multiple separate instruments on it designed to image and measure various properties of Uranus, its rings, and its moons. Uranus and Neptune should have enormous liquid oceans beneath their atmospheres, and an orbiter should be able to discover it for certain. The atmospheric probe would measure cloud-forming molecules, heat distribution, and how wind speed changed with depth. Originally, missions were focused on just one world at a time: Uranus as the higher-priority one (because it’s closer and has been studied for longer), and Neptune as the secondary one.

    As proposed by the ESA’s Cosmic Vision program, the Origins, Dynamics, and Interiors of the Neptunian and Uranian Systems (ODINUS) mission goes even farther: expanding this concept to two twin orbiters, where we would send one to Neptune and one to Uranus. A launch window in 2034, where Earth, Jupiter, Uranus, and Neptune all align properly, could send them both off simultaneously. The scientific advantages of orbiters over a flyby mission are tremendous: longer observing times over much longer temporal baselines, the ability to focus on multiple targets over time, and the ability to discover features you may not have even anticipated would be there. Its proposed suite of six-to-eight instruments would not just take images and spectra, but seismic, magnetic, and ion measurements. The only additional costs are in terms of fuel, and enabling your orbiting spacecraft to perform burns, slow down, and enter and maintain stable orbits. The deluge of science that you get from remaining around a planet, long term, more than makes up for those increased costs.

    A close-up of a cylindrical, reddish-brown solid object with a rounded top, resting on a surface dusted with dark powder—resembling something you might find during a mission to Uranus or Neptune.

    A Plutonium-238 oxide pellet glowing from its own heat. Also produced as a by-product of nuclear reactions, Pu-238 is the radionuclide used to power deep-space vehicles, from the Mars Curiosity Rover to the ultra-distant Voyager spacecraft. It is most useful very far from the Sun, and Pu-238 also powered the Cassini and Galileo missions.

    Credit: Los Alamos National Laboratory/Department of Energy

    The current limitations on a mission like this don’t come from technical accomplishments; the technology exists to do it today. The difficulties are a combination of:

    • political, arising from NASA’s finite, limited, and threatened budget,
    • physical, because even with low-cost, heavy payload launch vehicles, we can still only send a limited amount of overall mass to the outer Solar System,
    • and practical, because at these incredible distances from the Sun, solar panels will not power a sustained mission.

    That practical limitation requires a power source of radioactive isotopes, with the radioisotope thermoelectric generator (RTG) Plutonium-238 serving as our preferred source for such missions.

    However, most places in the world stopped producing Pu-238 back in the 20th century, and if we want enough to power a dual orbiter mission to Uranus and Neptune by the time the launch window arrives in 2034, we should really start producing it now. For the New Horizons mission to Pluto, an orbiter would have been a much more challenging mission strategy; New Horizons was too small and its speed was far too great, plus Pluto’s mass is quite low for attempting an orbital insertion. But for Neptune and Uranus, particularly if we choose the right gravity assists from Jupiter (and possibly Saturn), this could be feasible.

    A unique, dual mission to both Uranus and Neptune could be launched in 2034, allowing us to fill in the biggest gaps in our knowledge of the Solar System: the gaps of what’s truly happening on and around our final two planets. The only way we’ll find out is if we dare and go look at what’s out there.

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  • Verdane invests in Guardsquare to scale mobile security solutions for all businesses

    Verdane invests in Guardsquare to scale mobile security solutions for all businesses

    With the rapid evolution of the mobile threat landscape, this partnership expands access to the most comprehensive mobile application security

    LEUVEN, Belgium – July 3, 2025 – Verdane, the European specialist growth investment firm, is entering a partnership with Guardsquare, a leader in mobile application security. The partnership follows previous investment from Battery Ventures and addresses the growing mobile app security threats by expanding access to GuardSquare’s critical mobile application security for global businesses of all sizes. It also combines Guardsquare’s deep technical expertise with Verdane’s growth strategy through M&A and continued organic growth. 

    Mobile applications are increasingly becoming the primary way users interact with businesses. Yet, mobile app security needs have historically remained underserved, especially as threat actors target mobile apps at an accelerated pace. Verdane’s investment enables Guardsquare to expand its reach in providing the most comprehensive approach to mobile application security on the market, delivering the highest level of protection with ease. ​​Earlier this year, Cyber Defense Magazine recognized Guardsquare as the market leader in Mobile App Security and honored the company with its prestigious Mobile App Security Award.

    “I’m excited to embark on this new partnership with Verdane. It marks an inspiring and well-aligned progression toward our long-term vision. We will benefit from their expertise as, together, we take Guardsquare to the next level, significantly expand our market share, and increase our global reach through organic growth, ongoing product enhancements, and M&A,” said Roel Caers, CEO at Guardsquare. “We’re grateful for the support provided by Battery Ventures over the past several years as we became the market leader in mobile application protection. Their guidance enabled us to scale our business globally and attract top talent, particularly in the U.S.”

    “Guardsquare’s industry-leading mobile application protection is a critical cybersecurity service, and we’re excited to partner with Roel and the entire Guardsquare team to make this available for even more businesses globally. The company’s growth from a European to a global leader has been very impressive to behold, and we’re looking forward to supporting the company in its future journey,” said Morten Weicher, Partner at Verdane.

    “It has been a privilege to partner with the Guardsquare team and support the company’s growth journey. As it scaled its business, Guardsquare has consistently demonstrated its commitment to innovation and leadership in mobile application security,” said Dharmesh Thakker, Partner at Battery Ventures. “We are confident that this new partnership with Verdane will open up many new growth opportunities and allow Guardsquare to continue to help set the standard for mobile application security worldwide.”

    Completion of the transaction is subject to customary regulatory approvals.

    About Verdane
    Verdane is an independent specialist growth investment firm that partners with tech-enabled and sustainable European businesses. Verdane can invest as a minority or majority investor, either in single companies or through portfolios of companies, and looks to invest inside two core growth themes; digitalisation and decarbonisation. Verdane has more than €8 billion in assets under management and its funds have made over 200 investments in fast-growing businesses since 2003. Verdane’s team of over 150 investment professionals and operating experts, based out of Berlin, Munich, Copenhagen, Helsinki, London, Oslo and Stockholm, is dedicated to being the preferred growth partner to tech-enabled and sustainable businesses in Europe. Verdane is a UN PRI signatory and also a certified B Corporation, the most ambitious sustainability accreditation globally. The firm only backs businesses that pass its 2040 test, which indicates whether the company can thrive in a more sustainable future economy. Additionally, the Verdane Foundation, which is managed by the group, focuses on supporting sustainability globally and inclusion locally.

    About Guardsquare
    Guardsquare offers the most complete approach to mobile application security on the market, delivering the highest level of protection in the easiest possible way. Guardsquare’s software integrates seamlessly across the development cycle, from app security testing to code hardening to real-time visibility into the threat landscape. Guardsquare products provide enhanced mobile application security from early in the development process through publication. More than 900 organizations worldwide across all major industries rely on Guardsquare to help them identify security risks and protect their mobile applications and SDKs against reverse engineering and tampering in the ever-evolving threat landscape. Learn more at Guardsquare.com and on LinkedIn.

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  • Apheresis May Sweep Microplastics From Veins

    Apheresis May Sweep Microplastics From Veins

    Microplastics are particles ranging from 1 micrometer to 5 millimeters in diameter, and nanoplastics, which are even smaller, are found in virtually every environment on Earth, from mountain peaks to ocean depths, and from the smallest animals in the food chain to human brain cells.

    These particles can originate from the breakdown of larger plastic items or be intentionally manufactured for use in products, such as cosmetics, synthetic fabrics, and pharmaceuticals. Recent studies suggest that the human brain may contain up to a teaspoon of microplastics and nanoplastics, with the tiniest fragments primarily composed of polyethylene, the same material commonly used in plastic bags and food packaging.

    These particles have been detected in areas such as the walls of blood vessels in the brain and within immune cells. However, it remains unclear whether microplastics contribute to the progression of neurological diseases or whether these conditions render the brain more susceptible to particle infiltration. In animal studies involving fish and rodents, prolonged exposure to nanoplastics has been linked to memory impairment, brain inflammation, and alterations in synaptic protein levels.

    Beyond the brain, microplastics have been found in human feces, arterial plaques, and even the placenta. A study published in The New England Journal of Medicine linked the presence of microplastics in the arteries to a heightened risk for heart attack, stroke, and overall mortality.

    Therapeutic Apheresis

    According to a preliminary study published in Brain Medicine by researchers at Technische Universität Dresden in Dresden, Germany, therapeutic apheresis, a medical procedure that filters tiny particles from the blood, may help remove microplastics from the human body. The technique can capture particles as small as 200 nanometers, which is approximately 5000 times smaller than a millimeter.

    In this study, the researchers evaluated the procedure in patients with myalgic encephalomyelitis, also known as chronic fatigue syndrome. They analyzed the waste fluid discarded during apheresis using a specialized infrared spectroscopy technique.

    The analysis detected substances that matched the chemical signatures of polyamide and polyurethane, two common types of industrial plastics. This suggests that microplastics may have been successfully removed from the blood of patients during the procedure.

    Notably, this study did not measure the total amount of microplastics removed or compare their levels in patients before and after apheresis. What has been demonstrated so far is the presence of microplastics in the waste material discarded by the device — an observation that suggests, but does not yet confirm, the effective removal of these substances from the human body.

    Researchers have cautioned that the detected materials may reflect chemical structures common to proteins, meaning that further analysis is required to verify the exact nature of the removed particles. Nonetheless, the findings offer hope to researchers seeking to address the growing accumulation of microplastics in the human body.

    The authors recommended conducting studies with larger groups and quantitative analyses comparing the levels of microplastics in the blood before and after the procedures. The authors concluded that “such analyses will help determine particle removal from blood and tissues and assess correlations with symptom improvement in conditions like myalgia encephalomyelitis/chronic fatigue syndrome.”

    Alternative Approaches

    Currently, evidence that microplastics are effectively removed from the human body after ingestion is limited.

    A 2011 study examined bisphenol A (BPA) levels in blood, sweat, and urine samples from 20 individuals. In 16 cases, BPA appeared only in sweat, suggesting that induced perspiration may help eliminate certain compounds from the body. However, more studies are needed to assess its long-term safety and efficacy.

    “That is why we focus on reducing exposure to microplastics in the first place,” said Nicholas Fabiano, MD, a psychiatry resident at the University of Ottawa, Ottawa, Ontario, Canada, and co-author of a related article in Brain Medicine.

    The challenge of this research began with tracking the effects of microplastic particles. “From a clinical perspective, it is very difficult to establish a direct link between exposure to microplastics and adverse health outcomes,” said Fabiano.

    To address this, he advocated the creation of new tools to measure dietary risks, such as a dietary microplastic index. “We propose the development of a Dietary Microplastic Index that could be integrated with existing dietary risk assessment tools to estimate microplastic exposure based on the types of food consumed,” he said.

    This story was translated from Medscape’s Portuguese edition

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  • Measuring tumor force offers new clues for brain cancer treatment

    Measuring tumor force offers new clues for brain cancer treatment

    As brain tumors grow, they must do one of two things: push against the brain or use finger-like extensions to invade and destroy surrounding tissue.

    Previous research found tumors that push – or put mechanical force on the brain – cause more neurological dysfunction than tumors that destroy tissue. But what else can these different tactics of tumor growth tell us?

    Now, the same team of researchers from the University of Notre Dame, Harvard Medical School/Massachusetts General Hospital, and Boston University has developed a technique for measuring a brain tumor’s mechanical force and a new model to estimate how much brain tissue a patient has lost. Published in Clinical Cancer Research, the study explains how these measurements may help inform patient care and be adopted into surgeons’ daily workflow.

    During brain tumor removal surgery, neurosurgeons take a slice of the tumor, put it on a slide and send it to a pathologist in real-time to confirm what type of tumor it is. Tumors that originally arise in the brain, like glioblastoma, are prescribed different treatments than tumors that metastasize to the brain from other organs like lung or breast, so these differences inform post-surgical care. By adding a two-minute step to a surgeon’s procedure, we were able to distinguish between a glioblastoma tumor versus a metastatic tumor based on mechanical force alone.” 


    Meenal Datta, assistant professor of aerospace and mechanical engineering at Notre Dame and co-lead author of the study

    Datta and collaborators collected data from 30 patients’ preoperative MRIs and their craniotomies, which include exposing the brain and using Brainlab neuronavigation technology. This technology provides surgeons with real-time, 3D visualization during brain surgeries and is considered commonly available for neurological procedures. Neurosurgeons can use this technique to measure the bulge caused by brain swelling from the tumor’s mechanical forces before the tumor is resected.

    Then this patient data was used to determine whether brain tissue was displaced by a tumor’s mechanical force or replaced by a tumor. The researchers found that when there is more mechanical force on the brain (displacement), the swelling will be more substantial. But when a tumor invades and destroys surrounding tissue (replacement), the swelling will be less significant.

    The researchers created computational models based on a point system of measurements and biomechanical modeling that can be employed by doctors to measure a patient’s brain bulge, to determine the mechanical force that was being exerted by the tumor, and to determine the amount of brain tissue lost in each patient.

    Funded by the National Institutes of Health, National Science Foundation and various cancer research foundations, this study is among the first to show how mechanics can distinguish between tumor types.

    “Knowing the mechanical force of a tumor can be useful to a clinician because it could inform patient strategies to alleviate symptoms. Sometimes patients receive steroids to reduce brain swelling, or antipsychotic agents to counter neurological effects of tumors,” said Datta, an affiliate of Notre Dame’s Harper Cancer Research Institute. Datta recently showed that even affordable and widely used blood pressure medications can counter these effects. “We’re hoping this measurement becomes even more relevant and that it can help predict outcomes of chemotherapy and immunotherapy.”

    To get a better idea of what else mechanical force could indicate, the research team used animal modeling of three different brain tumors: breast cancer metastasis to the brain, glioblastoma and childhood ependymoma.

    In the breast cancer metastasis tumor, researchers used a form of chemotherapy that is known to work in reducing metastasis brain tumor size. While waiting for the tumor to respond to the chemotherapy, the team found that a reduction in mechanical force changed before the tumor size was shown to change in imaging.

    “In this model, we showed that mechanical force is a more sensitive readout of chemotherapy response than tumor size,” Datta said. “Mechanics are sort of disease-agnostic in that they can matter regardless of what tumor you are looking at.”

    Datta hopes that doctors employ the patient models from the study to continue to grow the field’s understanding of how mechanical force can improve patient care management.

    In addition to Datta, co-lead authors include Hadi T. Nia at Boston University, Ashwin S. Kumar at Massachusetts General Hospital and Harvard Medical School, and Saeed Siri at Notre Dame. Other collaborators include Gino B. Ferraro, Sampurna Chatterjee, Jeffrey M. McHugh, Patrick R. Ng, Timothy R. West, Otto Rapalino, Bryan D. Choi, Brian V. Nahed, Lance L. Munn and Rakesh K. Jain, all at Massachusetts General Hospital and Harvard Medical School.

    Datta is also affiliated with Notre Dame’s Eck Institute for Global Health, the Berthiaume Institute for Precision Health, NDnano, the Warren Center for Drug Discovery, the Lucy Family Institute for Data & Society and the Boler-Parseghian Center for Rare Diseases. She is also a concurrent faculty member in the Department of Chemical and Biomolecular Engineering and a faculty adviser for Notre Dame’s graduate programs in bioengineering and materials science and engineering.

    Source:

    Journal reference:

    Nia, H. T., et al. (2025). Solid Stress Estimations via Intraoperative 3D Navigation in Patients with Brain Tumors. Clinical Cancer Research. doi.org/10.1158/1078-0432.ccr-24-4159.

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