“Thanks to the events that will enliven Italy in the coming weeks and the torchbearers we helped select, we want to make this a moment of active participation, close to the people, cities and their communities. Since 1928, alongside the Olympic…
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We welcome FDA moves to cut primate testing as roadmap begins to take shape
The U.S. Food and Drug Administration (FDA) has issued new draft guidance to reduce the use of non-human primates for certain monoclonal antibody (mAb) products. These laboratory-produced antibodies are engineered to target disease in the same way as those naturally made by the immune system.
For monospecific antibodies, which target one specific molecule, and work through well-understood human biology, the FDA indicates that long-term primate toxicity studies lasting six months may be reduced or removed altogether. The agency also points to the increasing use of modern human-relevant tools, such as computer-based methods, organoid systems and real-world human safety data, to help assess the safety of new medicines.
This reflects long-standing scientific concerns about how inaccurately primate studies predict human responses for many biological products, and represents a practical step toward more efficient, human-focused drug evaluation. The proposal is also consistent with the FDA’s 2025 roadmap to reduce reliance on animal testing.
Actions like this are important because progress depends on implementation, not just intention. Roadmaps only deliver meaningful change when high-level commitments are followed by concrete steps, and this draft guidance is a welcome indication that the FDA is beginning to put its strategy into practice.
There are further opportunities to build on this progress, including addressing animal tests highlighted in our Replace Animal Tests (RAT) List. These tests continue despite the availability of valid non-animal methods, largely because of gaps in guidance and slow removal of outdated requirements. Whilst only some are relevant to the FDA, the principle remains clear: when reliable non-animal methods are available, they should be used in place of animal tests.
The draft guidance also reflects scientific principles we consistently highlight through our role as Secretariat to the International Council on Animal Protection in Pharmaceutical Programs (ICAPPP). These include reducing the reliance on specific animal species as the default option, selecting models based on biological relevance, and using more human-relevant tools such as cell-based and computer-based methods. This is relevant because the FDA’s proposal is intended to supplement international guidance on medicines testing, including regulation ICH S6, which ICAPPP has encouraged regulators to review. It is promising to see these concepts gaining momentum in wider efforts to update regulations.
Looking ahead, additional opportunities exist to modernise international requirements. One important area is the routine use of a second species (typically dogs) in medicines testing. This requirement is embedded in ICH M3, another internationally used guideline for medicines testing. Growing evidence supports a more flexible, science-driven approach that would reduce unnecessary animal testing. We have done extensive work on this and hope that progress to reduce primate testing will help spark broader updates to outdated regulatory testing requirements.
Our Deputy Director of Science and Regulatory Affairs, Laura Alvarez, said: “Reducing tests on primates is a sensible and necessary step away from outdated methods and towards modern, human-relevant science. We are encouraged to see movement on the FDA’s roadmap and hope this progress accelerates a wider transition away from long-standing animal testing requirements where non-animal approaches exist.”
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S&P 500 Futures Push Higher With Record in Sight: Markets Wrap
(Bloomberg) — The S&P 500 is set to continue its advance toward a new all-time high as the prospect of interest-rate cuts and confidence in the economy fuel investors’ appetite for risk.
Futures on the US benchmark rose on Friday after the index closed within 0.5% of a fresh record. The gauge is set for its first back-to-back weekly gain since October, signaling that traders are shaking off November’s jitters over valuations and the lack of visibility on the economy during the data blackout.
Nasdaq 100 contracts climbed 0.4%, while European and Asian gauges also added to the week’s gains. A measure of volatility dropped to the lowest since October. The dollar slipped, while Treasuries steadied. Bitcoin nudged lower toward $91,000.
With a rate cut next week largely priced in and bets pointing to further easing into 2026, investors are gearing up for a year-end rally in what is typically a supportive month for stocks. Growing confidence that the US economy remains resilient, despite softer employment, is also prompting rotations into stocks that tend to benefit from domestic strength.
“Santa will bring presents for everybody, toys for the kids and gains for investors,” said Stephan Kemper, chief investment strategist at BNP Paribas Wealth Management. “Apart from the regular seasonality there are plenty of other reasons supporting the market: rate cuts and ongoing M&A activity are some of them.”
Later on Friday, markets will a get a dated reading on the Federal Reserve’s preferred inflation gauge. The figures will include the personal consumption expenditures price index and a core measure that excludes food and energy.
Economist project a third-straight 0.2% increase in the core index for September. That would keep the year-over-year figure hovering a little below 3%, a sign that inflationary pressures are stable, yet sticky.
While the data is unlikely to derail a December rate cut, it “may change the tone from Chairman Powell,” said Wolf von Rotberg, equity strategist at Bank J Safra Sarasin. “If he emphasizes inflation risks in his press conference, markets may reprice the rate trajectory for 2026, thereby increasing the pressure on the long end of the curve and on equity market valuations.”
The September income and spending report — also delayed because of a government shutdown — is due to be released as well.
In a sign that institutional appetite for the world’s largest cryptocurrency remains subdued, BlackRock Inc.’s iShares Bitcoin Trust recorded its longest streak of weekly withdrawals since debuting in January 2024.
Investors pulled more than $2.7 billion from the exchange-traded fund over the five weeks to Nov. 28, according to data compiled by Bloomberg. With an additional $113 million of redemptions on Thursday, the ETF is now on pace for a sixth straight week of net outflows.
In commodities, copper rose to a record after a bullish price outlook from Citigroup Inc. and expectations of a shortage caused by stockpiling in the US. Gold headed for the biggest gain in a week. Brent crude fluctuated near $63 a barrel.
Corporate News
Health-care group Cooper Cos’ shares jumped in premarket trading after a guidance beat and the launch of a strategic review. Moore Threads Technology Co., a leading Chinese artificial intelligence chipmaker, soared as much as 502% in its Shanghai debut after raising 8 billion yuan ($1.13 billion) in an IPO. Warner Bros. Discovery Inc. has entered exclusive negotiations to sell its film and TV studios and HBO Max streaming service to Netflix Inc., according to people familiar with the discussions. Nvidia Corp. would be barred from shipping advanced artificial intelligence chips to China under bipartisan legislation unveiled Thursday in a bid to codify existing US restrictions on exports of advanced semiconductors to the Chinese market. Swiss Re AG announced its first share buyback in five years while disclosing a $250 million charge. Some of the main moves in markets:
Stocks
The Stoxx Europe 600 rose 0.3% as of 10:43 a.m. London time S&P 500 futures rose 0.2% Nasdaq 100 futures rose 0.4% Futures on the Dow Jones Industrial Average were little changed The MSCI Asia Pacific Index was little changed The MSCI Emerging Markets Index rose 0.8% Currencies
The Bloomberg Dollar Spot Index was little changed The euro was little changed at $1.1649 The Japanese yen was little changed at 155.09 per dollar The offshore yuan was little changed at 7.0674 per dollar The British pound was little changed at $1.3338 Cryptocurrencies
Bitcoin fell 0.8% to $91,427.4 Ether rose 0.7% to $3,144.68 Bonds
The yield on 10-year Treasuries was little changed at 4.11% Germany’s 10-year yield was little changed at 2.78% Britain’s 10-year yield was little changed at 4.44% Commodities
Brent crude fell 0.1% to $63.17 a barrel Spot gold rose 0.4% to $4,224.07 an ounce This story was produced with the assistance of Bloomberg Automation.
–With assistance from Neil Campling and Sidhartha Shukla.
©2025 Bloomberg L.P.
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OLAF awarded for protecting industrial and intellectual property rights in Europe
The European Anti-Fraud Office (OLAF) received a prestigious award from the Association for the Defence of Trademarks (ANDEMA), Spain’s leading industrial property body, in recognition of its outstanding commitment to combating counterfeiting and defending intellectual and industrial property rights across Europe.
The award was presented during a ceremony held on 27 November in Barcelona, as part of the European Industrial Property Forum. OLAF accepted the honour, underscoring its enduring role in safeguarding a fair, safe and competitive European market.
“ANDEMA’s recognition is a tribute to the work carried out by OLAF across borders to uphold legality and protect fundamental rights in the internal market. It also reinforces the importance of sustained cooperation with our partners. Our joint expertise and commitment make it possible to fight against increasingly sophisticated counterfeit networks,” said Ernesto Bianchi, Director of Investigations and International Operations at OLAF.
OLAF’s work in protecting intellectual property and tackling counterfeits is essential for building trust among EU citizens, businesses and institutions. Counterfeits undermine legitimate economic activity and erode confidence in the internal market. Even more worrisome, counterfeits pose serious risks to consumer health and safety, as well as to the environment, because they often bypass quality controls, use hazardous materials and generate untraceable waste. By coordinating effective, cross-border actions with partners such as EUIPO, customs authorities and international stakeholders, OLAF helps ensure that European industry and consumers are shielded from the damaging effects of counterfeits.
In recent years, OLAF has stepped up joint efforts with the European Union Intellectual Property Office (EUIPO) in strategic initiatives tackling some of the most pressing threats such as online counterfeiting and e-commerce fraud, counterfeiting of construction materials as well as everyday products.
Background
Counterfeits pose a wide range of risks. Beyond economic harm, counterfeits can threaten consumer health and safety, distort competition, and damage technological innovation and job creation. OLAF’s interventions help preserve consumer trust in markets and foster a level playing field for businesses of all sizes.
Through its investigations, partnerships and anti-fraud strategy, OLAF continues to support a European marketplace that rewards creativity, safeguards legality and protects consumer confidence.
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Strava says the most popular running shoe is now made by Asics — dethroning a long-time Nike favourite
Strava has revealed the most-worn running shoe of 2025, and for the first time in years, it’s not the Nike Pegasus taking the top spot.
Instead, a different daily trainer has surged ahead. The Asics Novablast is officially the most popular…
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Anahat Singh beats Joshna Chinappa in final to win HCL Squash Indian Tour 4 title in Chennai
India’s rising star Anahat Singh extended her winning run over veteran Joshna Chinappa to clinch the women’s title at the HCL Squash Indian Tour 4, Chennai 2025 tournament on Saturday.
In the men’s draw, India’s Velavan Senthilkumar beat…
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Update Now — Nvidia Confirms New Security Vulnerabilities
Update Nvidia Triton Inference Server now.
Getty Images
Nvidia is no longer just the company that produces the graphics processing units found in your computer. The first company to hit a $5 trillion market cap, Nvidia is a global player in the AI…
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NA Speaker Pays Tribute to Nishan-e-Haider Martyr Major Muhammad Akram on 54th Martyrdom Anniversary – https://www.dailyindependent.com.pk
NA Speaker Pays Tribute to Nishan-e-Haider Martyr Major Muhammad Akram on 54th Martyrdom Anniversary – https://www.dailyindependent.com.pk
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League of Legends named most popular game in Discord 2025 review – Esports Insider
- League of Legends named most popular game in Discord 2025 review Esports Insider
- How to get your 2025 Discord Checkpoint recap Dexerto
- Discord Checkpoints rolls out year-in-review recap today, here’s exactly how to find yours and what your…
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‘Emily in Paris’ star Jeremy O. Harris arrested in Japan on drug allegations amid ongoing investigation
Harris has been in custody for 18 days after authorities reportedly found a small amount of MDMA in his luggage
Jeremy O. Harris has been detained in…
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