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  • Fujifilm X T50 Kit Hits Its Lowest Price In 30 Days During Amazon’s Black Friday Festival

    Fujifilm X T50 Kit Hits Its Lowest Price In 30 Days During Amazon’s Black Friday Festival

    The Fujifilm X T50 kit has quietly dropped to its lowest price in 30 days, right in the middle of Amazon’s massive Black Friday atmosphere. It is one of those cool and practical additions to the festival lineup, offering a compact…

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  • Milkesa Mengesha and Brigid Kosgei seal Shanghai Marathon 2025 titles

    Milkesa Mengesha and Brigid Kosgei seal Shanghai Marathon 2025 titles

    Ethiopia swept the podium in the men’s elite race, with 2024 Berlin Marathon winner Milkesa Mengesha claiming victory in 2:06:25, narrowly ahead of compatriot Dawit Wolde (2:06:27) and Deresa Geleta (2:06:36).

    The wheelchair events were both…

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  • Sanya Vats wins maiden PSA title at JSW Sunil Verma Memorial 2025 squash

    Sanya Vats wins maiden PSA title at JSW Sunil Verma Memorial 2025 squash

    Indian squash player Sanya Vats defeated compatriot Nirupama Dubey in the final to win the women’s title at the JSW Sunil Verma Memorial 2025 squash tournament, which concluded in Thane, Maharashtra, on Sunday.

    Fifth seed Sanya Vats, a former…

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  • Taylor Swift Just Taught a Master Class in How to Be Likable. Anyone Can Do It – Inc.com

    1. Taylor Swift Just Taught a Master Class in How to Be Likable. Anyone Can Do It  Inc.com
    2. How Taylor Swift secretly jetted 3,500 miles from US to film new music video in Croydon shopping centre  The Sun
    3. Why Fans Think Taylor Swift Is Filming an…

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  • The Strategist locks in their Lusail picks

    The Strategist locks in their Lusail picks

    It’s time for the penultimate round of the 2025 season – and in Qatar, strategy is in the balance.

    Pirelli’s mandatory 25-lap stint limit means every driver must make at least two pit stops, transforming Sunday’s race. With Carlos starting…

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  • Ascletis Selects Its First Oral GLP-1R/GIPR/GCGR Triple Peptide Agonist, ASC37, for Clinical Development

    –  Utilizing Ascletis’ Peptide Oral Transport ENhancement Technology (POTENT), ASC37 oral tablets achieved average absolute oral bioavailability of 4.2%, approximately 9, 30, and 60-fold higher than semaglutide, tirzepatide, and retatrutide in the oral SNAC formulation, respectively, in head-to-head non-human primate (NHP) studies.

    –  ASC37 oral tablets’ drug exposure, as measured by the area under curve (AUC), was approximately 57-fold of retatrutide’s drug exposure in head-to-head NHP studies.

    –  Average observed half-life of ASC37 oral tablets was approximately 56 hours in NHP studies, supporting once daily and less frequent oral dosing.

    –  ASC37 in vitro activity was approximately 5-, 4- and 4-fold more potent than retatrutide for GLP-1R, GIPR and GCGR, respectively.

    –  Submission of an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC37 oral tablets is expected in the second quarter of 2026.

    –  The Company will host a conference call in Mandarin at 10:00 a.m. China Standard Time on December 1, 2025.

    HONG KONG, Nov. 30, 2025 /PRNewswire/ — Ascletis Pharma Inc. (HKEX: 1672, “Ascletis”) announces that it has selected ASC37 oral tablets, its first oral GLP-1R/GIPR/GCGR[1] triple peptide agonist, as a clinical development candidate. Ascletis expects to submit an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for ASC37 oral tablets for the treatment of obesity in the second quarter of 2026.

    ASC37 oral tablets is the Company’s first incretin drug candidate developed with its proprietary Peptide Oral Transport ENhancement Technology (POTENT). 

    ASC37, a GLP-1R, GIPR, and GCGR triple peptide agonist, was discovered and optimized in-house utilizing Ascletis’ Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD). ASC37 in vitro activity was approximately 5-, 4-, and 4-fold more potent than retatrutide for GLP-1R, GIPR and GCGR, respectively.

    Utilizing Ascletis’ POTENT technology, ASC37 oral tablets achieved average absolute oral bioavailability[2] of 4.2%, which was approximately 9-, 30-, and 60-fold higher than semaglutide, tirzepatide, and retatrutide in the oral SNAC [3] formulation, respectively, in head-to-head non-human primate (NHP) studies. Furthermore, after oral administration, ASC37 oral tablets’ drug exposure, as measured by the area under curve (AUC), with the POTENT formulation was approximately 57-fold of retatrutide’s drug exposure with the oral SNAC formulation, in head-to-head NHP studies.

    Average observed half-life of ASC37 oral tablets was approximately 56 hours in NHP studies, supporting once daily and less frequent oral dosing.

     “Selection of ASC37, a promising oral GLP-1R/GIPR/GCGR triple peptide agonist, for clinical development once again demonstrates our strong R&D capabilities and our commitment to address the unmet needs for the treatment of obesity,” said Jinzi Jason Wu, Ph.D., Founder, Chairman and CEO of Ascletis, “Leveraging our proprietary technology platforms, including AISBDD and POTENT, Ascletis has successfully established a highly competitive, differentiated and diverse pipeline portfolio which can potentially effectively address the various treatment needs of patients with obesity and other metabolic diseases.”

    [1] GLP-1R: glucagon-like peptide 1 receptor, GIPR: gastric inhibitory polypeptide receptor, GCGR: glucagon receptor

    [2] absolute oral bioavailability: the percentage of an orally administered drug that reaches the systemic circulation (bloodstream), compared to an intravenous (IV) dose of the same drug

    [3] SNAC: Salcaprozate Sodium

    Conference Call

    Ascletis will host a conference call in Mandarin at 10:00 a.m. China Standard Time on December 1, 2025. A live webcast of the call will be available via Tencent Meeting/ VooV Meeting, with the Meeting ID: 495-266-842, or access links of:

    Chinese Mainland: https://meeting.tencent.com/dm/10ve6whW8Rbl; or

    International: https://voovmeeting.com/dm/10ve6whW8Rbl.

    About Ascletis Pharma Inc.

    Ascletis Pharma Inc. is a fully integrated biotechnology company focused on the development and commercialization of potential best-in-class and first-in-class therapeutics to treat metabolic diseases. Utilizing its proprietary Artificial Intelligence-Assisted Structure-Based Drug Discovery (AISBDD) and Ultra-Long-Acting Platform (ULAP) technologies as well as Peptide Oral Transport ENhancement Technology (POTENT), Ascletis has developed multiple drug candidates in-house, including both small molecules and peptides, such as its lead program, ASC30, a small molecule GLP-1R agonist designed to be administered once daily orally and once monthly to once quarterly subcutaneously as a treatment therapy and a maintenance therapy for chronic weight management; ASC36, a once-monthly subcutaneously administered amylin receptor peptide agonist, ASC35, a once-monthly subcutaneously administered GLP-1R/GIPR dual peptide agonist and ASC37, an oral GLP-1R/GIPR/GCGR triple peptide agonist for chronic weight management. Ascletis is listed on the Hong Kong Stock Exchange (1672.HK).

    For more information, please visit www.ascletis.com.

    Contact:

    Peter Vozzo
    ICR Healthcare
    443-231-0505 (U.S.)
    [email protected] 

    Ascletis Pharma Inc. PR and IR teams
    +86-181-0650-9129 (China)
    [email protected]
    [email protected] 

    SOURCE Ascletis Pharma Inc.

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  • Doctor shares 6 superfoods that can improve blood sugar balance and insulin sensitivity: Chia seeds, apple cider vinegar

    Doctor shares 6 superfoods that can improve blood sugar balance and insulin sensitivity: Chia seeds, apple cider vinegar

    If you’re living with diabetes and looking to improve insulin sensitivity and stabilise your blood sugar, your everyday food choices can make a meaningful difference. Nutrition plays a central role in glucose management, and incorporating the…

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  • AC Milan take Serie A lead after fraught win over Lazio

    AC Milan take Serie A lead after fraught win over Lazio

    AC Milan’s Rafael Leao celebrates scoring their first goal. Photo: REUTERS


    MILAN:


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  • Popping antacids every day? Apollo doctor warns your ‘normal acidity’ may be a slow-burning disease leading to much serious issues

    Popping antacids every day? Apollo doctor warns your ‘normal acidity’ may be a slow-burning disease leading to much serious issues

    A daily cycle of heartburn, gas, and throat irritation may seem routine for many Indians who rely on antacids as casually as after-meal mints. But according to a recent public advisory by Surgical Gastroenterology Specialist Dr Anshuman Kaushal…

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  • AI-assisted shopping is the talk of the holiday shopping season

    AI-assisted shopping is the talk of the holiday shopping season

    NEW YORK (AP) — Major retail chains and tech companies are offering new or updated artificial intelligence tools in time for the holiday shopping season, hoping to give consumers an easier gift-buying experience and themselves an augmented share of online spending.

    Although AI-powered purchases are in early stages, the shopping assistants and agents rolled out by the likes of Walmart, Amazon and Google can do more than the chatbots of holidays past. The latest versions were designed to provide personalized product recommendations, track prices and to place some orders through unscripted “conversations” with customers.

    Those features are on top of shopping updates from AI platforms like OpenAI’s ChatGPT and Google Gemini. In one of the season’s most talked-about launches, Google this month introduced an AI agent that can be instructed to call local stores to ask if a desired product is in stock.

    San Francisco software company Salesforce estimated that AI would influence $73 billion, or 22%, of all global sales in one way or another from the Tuesday before Thanksgiving through Monday after the holiday, according to Caila Schwartz, Salesforce’s director of consumer insights.

    The figure, which stood at $60 billion a year ago, encompasses everything from a ChatGPT query to AI-supplied gift suggestions on a retailer’s website, Schwartz said.

    Despite the advancements, AI’s impact on holiday shopping will be “relatively limited” this year since not every shopping site has useful tools and not every shopper is willing to try them, said Brad Jashinsky, a senior retail industry analyst at information technology research and consulting firm Gartner.

    “The more retailers that launch these tools, the better they get, and the more that consumers get comfortable and start to seek them out,” Jashinsky said. “But customer behavior takes a long time to change.”

    Here are three ways the technology is poised to influence holiday shopping habits in 2025:

    Bypassing the search bar

    AI’s potential to simplify the search for the perfect present is most apparent so far in tools that promise to give shoppers faster and more detailed results than a web browser with a lot fewer clicks.

    OpenAI upgraded ChatGPT with a shopping research feature that provides personalized buyers’ guides. The information comes from product pages, reviews. prices and a user’s previous interactions with the chatbot. The tool works best for complicated products like electronics and appliances, or for “detail-heavy” items like beauty or sporting goods, OpenAI said.

    Then there’s Rufus, the shopping assistant that Amazon rolled out last year. It now remembers information customers previously fed it, like having four children that all like board games, for example. A user’s browsing and purchase history and reviews are used to personalize recommendations.

    Google upgraded its AI Mode search tool to provide answers to detailed questions composed in natural language. For example, users can tell the agent they want to buy a casual sweater to wear with skirt or jeans in New York in January that goes with a skirt or jeans,

    Responses are pulled from Google’s 50 billion product listings. The tool can also produce charts with side-by-side comparisons of prices, features, reviews and other factors. Previously, shoppers had to use keywords, filters and product links to find the information they needed.

    “This is an expansionary moment, I think, for all of technology and for commerce,” Lilian Rincon, vice president of product, consumer shopping at Google, recently told The Associated Press.

    Meanwhile, Walmart’s AI shopping assistant, Sparky, offers occasion-based recommendations and synthesizes reviews. An AI-powered gift finder on Target’s app exclusively for the holidays responds to prompts such as the age and special hobbies of the recipient.

    New pricing tools and alerts

    Tools for tracking online prices have been around for years, including CamelCamelCamel, a third-party service for Amazon prices, as well as Paypal’s Honey browser extension for monitoring thousands of online shops.

    This holiday season, shoppers have new options.

    Amazon launched a 90-day pricing history tracker this month for virtually everything it sells. Shoppers also now can set up alerts to receive notifications when prices on specific items fall within their budgets.

    Google, which for years had a basic price tracker, launched a more advanced version that lets users refine their requests with details like a garment’s size and color. Microsoft’s Copilot also launched a price tracker this year.

    Jason Goldberg, chief commerce strategy officer at Publicis Groupe, said he thinks the new pricing tools will add more pressure on retailers to make sure their prices are competitive.

    “A lot of consumers that weren’t even looking for price alerts are going to discover price alerts for the first time,” Goldberg predicted.

    New ways to buy

    Amazon, OpenAI and Google are racing to create tools that would allow for seamless AI-powered shopping by taking consumers from browsing to buying within the same program instead of having to go to a retailer’s website to complete a purchase.

    OpenAI launched a new instant checkout feature that lets users buy products suggested by ChatGPT without leaving the app. Users can order merchandise from Etsy sellers and from some brands that use Shopify, including Glossier, Skims and Spanx.

    OpenAI and Walmart announced a similar deal in October, saying the partnership would allow ChatGPT members to use the instant checkout feature to shop for nearly everything available on Walmart’s website except for fresh food. For now, however, the feature only supports buying one item at a time.

    A different deal Target struck with OpenAI lets shoppers put multiple items in a cart on ChatGPT, including fresh food products. But when customers are ready to pay for their orders, they are directed away from the chatbot to the Target app.

    New tools from Amazon and Google will give shoppers a taste of having autonomous AI assistants do the buying for them. While the services still are limited, “agentic AI” is intended to be more independent and advanced than the generative AI chatbots that excel at research and writing, experts say.

    Amazon is now letting Rufus automatically purchase items for customers who click an “auto buy” button while setting up price alerts. Once a product’s price drops to the desired level, customers receive notice of their completed orders and have a limited window to cancel, the company said.

    The e-commerce giant also started allowing shoppers to use Rufus searches for brand-name products on the Amazon app as a gateway to other retailers. If Amazon doesn’t carry a desired item in its store, a “Shop Direct” button will take them to the website of a place that does.

    Google’s AI Mode price tracker also includes a “buy for me” option that automatically makes a customer’s purchase through Google Pay when the price is right. The feature is available for products sold by Wayfair, Chewy, Quince and some Shopify merchants, and Google expects to keep adding more stores, the company said. sellers.

    Google also expanded its web browser with an automated AI call feature that phones local businesses on behalf of customers looking for information or specific products. Google’s program discloses to the store that it’s an AI caller, and stores can choose not to participate, the company said.

    Google said it’s applying the feature initially to specific product categories: toys, health and beauty, and electronics. Target and Walmart declined to comment on whether this type of service would be part of their future plans.

    Anne D’innocenzio, The Associated Press

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