Author: admin

  • a heartfelt Christmas tale in which comedy and crisis collide

    a heartfelt Christmas tale in which comedy and crisis collide

    Following a year in the life of an “ordinary” woman, Carol, Andrea Gibbs’ second play for Black Swan State Theatre Company is a real original.

    Moving between moments in front of the curtain and scenes behind the proscenium, the play…

    Continue Reading

  • Arista Shows Scale-Across Network Switches at SC25

    Arista Shows Scale-Across Network Switches at SC25

    Arista 7280R4K 64QC 10PE And 7060X6 64PE At SC25 1

    At SC25, we saw something neat in the Arista booth. Going through the photos, Arista showed off not just a high-throughput Broadcom Tomahawk switch, but also brought…

    Continue Reading

  • Asia extreme weather: Ninety dead in Indonesia floods as cyclone displaces thousands in Sri Lanka

    Asia extreme weather: Ninety dead in Indonesia floods as cyclone displaces thousands in Sri Lanka

    Exceptionally rare for cyclones to happen in Indonesia, says researcherpublished at 05:34 GMT

    Arie Firdaus
    BBC Indonesian

    The widespread flooding and landslides hitting Indonesia over the past few days have been triggered by Cyclone…

    Continue Reading

  • How Patrick Kavanagh’s immortal poem On Raglan Road was lost and then found – The Irish Times

    How Patrick Kavanagh’s immortal poem On Raglan Road was lost and then found – The Irish Times

    It’s unusual, if not rare, for a work by an acclaimed poet to appear in the pages of a national newspaper, only for it to vanish without trace, then resurface, 18 years later, and go on to become one of Ireland’s greatest poems.

    The poet was

    Continue Reading

  • 5 Fast Facts Our New Cell based Flu Vaccine and Antivenom Manufacturing Facility in Australia

    5 Fast Facts Our New Cell based Flu Vaccine and Antivenom Manufacturing Facility in Australia

    With the opening of its new high-tech vaccine manufacturing facility at Tullamarine, CSL Seqirus is turning the page.

    The site near Melbourne Airport includes three buildings and will have a gross floor area of 28,400m2, larger than the playing surface of the famous Melbourne Cricket Ground. The facility has been electrified and incorporates on-site solar energy generation, heat and water recovery to preserve a healthier environment.

    “This facility will build a platform for our next wave of innovation in vaccines and unique health challenges, setting a new standard of care,” said CSL Seqirus Managing Director Dave Ross, who will be on hand for the 2 December opening celebration.

    Globally, the World Health Organization estimates that seasonal flu infects 1 billion people annually, causing severe illness in 3-5 million and 290,000-650,000 respiratory deaths.

    Here are five facts about the new site, built to protect public health:

    1. It is the only manufacturing facility of its kind in the Southern Hemisphere.
    2. Considered modern, efficient and highly scalable, cell-based influenza vaccine manufacturing advances scalability, reduces reliance on large volumes of critical materials and enables rapid production of vaccines using state-of-the-art technology. That makes it well suited to pandemic preparedness. With year-round seasonal flu vaccine manufacturing, the Tullamarine facility will be ever ready to switch over to pandemic response.
    3. It features a digitally connected manufacturing environment, deploying advanced analytics that will drive innovation and optimise manufacturing operations. This includes a fully automated and paperless manufacturing execution system that will support our highly skilled workforce to optimise production, conduct predictive maintenance, improve quality control and reduce downtime.
    4. Tullamarine will support a supply chain worth $300 million with hundreds of experts on hand to ensure that essential vaccines and antivenoms reach the clinics and patients who need them.
    5. It will be the only manufacturing site in the world capable of producing Australia’s 11 antivenoms for venomous creatures and the human Q-Fever vaccine.

     

    Continue Reading

  • Australia names unchanged squad for second Ashes test against England next week in Brisbane

    Australia names unchanged squad for second Ashes test against England next week in Brisbane

    BRISBANE, Australia (AP) — Leading 1-0 in the five-test Ashes series after a stunning two-day win in the first test at Perth, Australia has named an unchanged squad for the day-night second match at the Gabba in Brisbane starting Dec. 4.

    Captain…

    Continue Reading

  • Ricoh recognized as a Prime Seat Company in the 2025 Nikkei SDGs Management Grand Prix | Global

    Ricoh recognized as a Prime Seat Company in the 2025 Nikkei SDGs Management Grand Prix | Global

    Ricoh is a leading provider of integrated digital services and print and imaging solutions designed to support digital transformation of workplaces, workspaces and optimize business performance.

    Headquartered in Tokyo, Ricoh’s global operation reaches customers in approximately 200 countries and regions, supported by cultivated knowledge, technologies, and organizational capabilities nurtured over its 85-year history. In the financial year ended March 2025, Ricoh Group had worldwide sales of 2,527 billion yen (approx. 16.8 billion USD).

    It is Ricoh’s mission and vision to empower individuals to find Fulfillment through Work by understanding and transforming how people work so we can unleash their potential and creativity to realize a sustainable future.

    For further information, please visit

    ###

    © 2025 RICOH COMPANY, LTD. All rights reserved. All referenced product names are the trademarks of their respective companies.

    Continue Reading

  • Hou, K. et al. Microbiota in health and diseases. Signal Transduct. Target. Ther. 7, 135 (2022).

    Google Scholar 

  • Aguilar-Lopez, M., Dinsmoor, A. M., Ho, T. T. B. & Donovan, S. M. A systematic review of the factors influencing microbial colonization of the preterm infant gut. Gut Microbes 13, 1–33 (2021).

    Google Scholar 

  • DeVeaux, A., Ryou, J., Dantas, G., Warner, B. B. & Tarr, P. I. Microbiome-targeting therapies in the neonatal intensive care unit: safety and efficacy. Gut Microbes 15, 2221758 (2023).

    Google Scholar 

  • Staude, B. et al. The microbiome and preterm birth: a change in paradigm with profound implications for pathophysiologic concepts and novel therapeutic strategies. Biomed. Res. Int. 2018, 7218187 (2018).

    Google Scholar 

  • Bårdsen, T. et al. Impaired lung function in extremely preterm-born adults in their fourth decade of life. Am. J. Respir. Crit. Care Med. 208, 493–495 (2023).

    Google Scholar 

  • Islam, J. Y., Keller, R. L., Aschner, J. L., Hartert, T. V. & Moore, P. E. Understanding the short- and long-term respiratory outcomes of prematurity and bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 192, 134–156 (2015).

    Google Scholar 

  • Bårdsen, T. et al. Tracking of lung function from 10 to 35 years after being born extremely preterm or with extremely low birth weight. Thorax 77, 790–798 (2022).

    Google Scholar 

  • Lee, D. M. X., Tan, A. K. S., Ng, Y. P. M. & Amin, Z. Quality of life of patients and caregivers affected by bronchopulmonary dysplasia: a systematic review. Qual. Life Res. 32, 1859–1869 (2023).

    Google Scholar 

  • Horbar, J. D. et al. Trends in mortality and morbidities for infants born 24 to 28 weeks in the US: 1997–2021. Pediatrics 153, e2023064153 (2024).

    Google Scholar 

  • Holzfurtner, L. et al. When inflammation meets lung development-an update on the pathogenesis of bronchopulmonary dysplasia. Mol. Cell Pediatr. 9, 7 (2022).

    Google Scholar 

  • Pammi, M. et al. Airway microbiome and development of bronchopulmonary dysplasia in preterm infants: a systematic review. J.Pediatr. 204, 126-133.e2 (2019).

    Google Scholar 

  • Young, K. C., Del Moral, T., Claure, N., Vanbuskirk, S. & Bancalari, E. The association between early tracheal colonization and bronchopulmonary dysplasia. J. Perinatol. 25, 403–407 (2005).

    Google Scholar 

  • Mourani, P. M., Harris, J. K., Sontag, M. K., Robertson, C. E. & Abman, S. H. Molecular identification of bacteria in tracheal aspirate fluid from mechanically ventilated preterm infants. PloS one 6, e25959 (2011).

    Google Scholar 

  • Ehrhardt, H. et al. Mode of delivery and incidence of bronchopulmonary dysplasia: results from the population-based EPICE cohort. Neonatology 119, 464–473 (2022).

    Google Scholar 

  • Staude, B. et al. Microbial signatures in amniotic fluid at preterm birth and association with bronchopulmonary dysplasia. Respir. Res. 24, 248 (2023).

    Google Scholar 

  • Lauer, T. et al. Bacterial Colonization within the First Six Weeks of Life and Pulmonary Outcome in Preterm Infants <1000 g. J. Clin. Med. 9, 2240 (2020).

    Google Scholar 

  • Rofael, S. A. D. et al. Airway microbiome in adult survivors of extremely preterm birth: the EPICure study. The European respiratory journal 53 (2019).

  • Dolma, K. et al. Effects of hyperoxia on alveolar and pulmonary vascular development in germ-free mice. Am. J. Physiol. Lung Cell.Mol. physiol. 318, L421–L428 (2020).

    Google Scholar 

  • Dong, Y. et al. Insights into the black box of intra-amniotic infection and its impact on the premature lung: from clinical and preclinical perspectives. Int. J. Mol. Sci. 23, 9792 (2022).

    Google Scholar 

  • Shrestha, A. K. et al. Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice. Am. J. physiol. Lung cell. Mol. Physiol. 316, L229–L244 (2019).

    Google Scholar 

  • Shrestha, A. K. et al. Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs. Am. J. physiol. Lung cell. Mol. Physiol. 319(L981), L996 (2020).

    Google Scholar 

  • Huang, J. et al. Human milk as a protective factor for bronchopulmonary dysplasia: a systematic review and meta-analysis. Arch. Dis. Child Fetal Neonatal. Ed. 104, F128–F136 (2019).

    Google Scholar 

  • Köstlin-Gille, N. et al. Early initiation of antibiotic therapy and short-term outcomes in preterm infants: a single-centre retrospective cohort analysis. Arch. Dis. Child. Fetal Neonatal Ed. 108(623), 630 (2023).

    Google Scholar 

  • Romijn, M. et al. Prediction models for bronchopulmonary dysplasia in preterm infants: a systematic review and meta-analysis. J. Pediatr. 258, 113370 (2023).

    Google Scholar 

  • Christoph J et al. Risikocharakterisierung Intensivmedizinisch Behandelter Früh- Und Neugeborener Und Daten Zur Ist-Situation in Deutschen Neonatologischen Intensivpflegestationen 2013 – Fachliche Erläuterungen Zu Folgender Empfehlung: Praktische Umsetzung Sowie Krankenhaushygienische Und Infektionspräventive Konsequenzen Des Mikrobiellen Kolonisationsscreenings Bei Intensivmedizinisch Behandelten Früh- Und Neugeborenen Ergänzende Empfehlung Der Kommission Für Krankenhaushygiene Und Infektionsprävention (KRINKO) Beim Robert Koch-Institut, Berlin Zur Implementierung Der Empfehlungen Zur Prävention Nosokomialer Infektionen Bei Neonatologischen Intensivpflegepatienten Mit Einem Geburtsgewicht Unter 1.500 g Aus Dem Jahr 2007 Und 2012. 42 (Epidemiologisches Bulletin des Robert Koch-Instituts, Berlin, 2013).

  • Parm, U. et al. Risk factors associated with gut and nasopharyngeal colonization by common gram-negative species and yeasts in neonatal intensive care units patients. Early Hum. Dev. 87, 391–399 (2011).

    Google Scholar 

  • Sgro, M. et al. Early-onset neonatal sepsis: rate and organism pattern between 2003 and 2008. J. Perinatol. : Off. J. California Perinat. Assoc. 31, 794–798 (2011).

    Google Scholar 

  • Kaufman, D. & Fairchild, K. D. Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants. Clin. Microbiol. Rev. 17, 638–80 (2004).

    Google Scholar 

  • Joubert, I. A., Otto, M., Strunk, T. & Currie, A. J. Look who’s talking: host and pathogen drivers of staphylococcus epidermidis virulence in neonatal sepsis. Int. J. Mol. Sci. 23, 860 (2022).

    Google Scholar 

  • Davis, E. C. et al. Gut microbiome and breast-feeding: Implications for early immune development. J.Allergy Clin. Immunol. 150, 523–534 (2022).

    Google Scholar 

  • Thiess, T. et al. Correlation of early nutritional supply and development of bronchopulmonary dysplasia in preterm infants <1,000 g. Front. Pediatr. 9, 741365 (2021).

    Google Scholar 

  • Voigt, M., Schneider, K. T. M. & Jährig, K. Analyse des Geburtengutes des Jahrgangs 1992 der Bundesrepublik Deutschland [Analysis of a 1992 birth sample in Germany. 1: New percentile values of the body weight of newborn infants]. Geburtshilfe Frauenheilkd 56, 550–558 (1996).

  • Jobe, A. H. & Bancalari, E. Bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 163, 1723–1729 (2001).

    Google Scholar 

  • Fawke, J. et al. Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study. Am. J. Respire. Crit. Care Med. 182, 237–245 (2010).

    Google Scholar 

  • Walter, S. D., Feinstein, A. R. & Wells, C. K. Coding ordinal independent variables in multiple regression analyses. Am. J. Epidemiol. 125, 319–323 (1987).

    Google Scholar 

  • Wood, S. N. Generalized Additive Models: An Introduction with R, Second Edition. (Chapman and Hall/CRC, New York). https://doi.org/10.1201/9781315370279. (2017)

  • Gertheiss, J., Scheipl, F., Lauer, T. & Ehrhardt, H. Statistical inference for ordinal predictors in generalized additive models with application to bronchopulmonary dysplasia. BMC Res. Notes 15, 112 (2022).

    Google Scholar 

  • Hothorn, T., Hornik, K. & Zeileis, A. Unbiased recursive partitioning: a conditional inference framework. J. Comput. Graphical Stat. 15, 651–674 (2006).

    Google Scholar 

  • Strobl, C., Boulesteix, A.-L., Kneib, T., Augustin, T. & Zeileis, A. Conditional variable importance for random forests. BMC Bioinform. 9, 307 (2008).

    Google Scholar 

  • R Core Team. R: A Language and Environment for Statistical Computing. (2023).

  • Rückle, X. et al. Different probiotic strains alter human cord blood monocyte responses. Pediatr. Res. 94, 103–111 (2023).

    Google Scholar 

  • Samara, J. et al. Supplementation with a probiotic mixture accelerates gut microbiome maturation and reduces intestinal inflammation in extremely preterm infants. Cell Host Microbe 30, 696-711.e5 (2022).

    Google Scholar 

  • Elazab, N. et al. Probiotic administration in early life, atopy, and asthma: a meta-analysis of clinical trials. Pediatrics 132, e666-76 (2013).

    Google Scholar 

  • Collins, J. J. P. et al. Repeated intrauterine exposures to inflammatory stimuli attenuated transforming growth factor-\textgreekb signaling in the ovine fetal lung. Neonatology 104, 49–55 (2013).

    Google Scholar 

  • Azizia, M., Lloyd, J., Allen, M., Klein, N. & Peebles, D. Immune status in very preterm neonates. Pediatrics 129, e967-74 (2012).

    Google Scholar 

  • Schmidt, B., Roberts, R., Millar, D. & Kirpalani, H. Evidence-based neonatal drug therapy for prevention of bronchopulmonary dysplasia in very-low-birth-weight infants. Neonatology 93, 284–287 (2008).

    Google Scholar 

  • Brewer, M. R. et al. Determinants of the lung microbiome in intubated premature infants at risk for bronchopulmonary dysplasia. J. Maternal-fetal Neonatal Med.:Official J. Euro. Assoc. Perinat. Med. Federation Asia Oceania Perinat. Soc. Int. Soc. Perinat. Obstetricians 34, 3220–3226 (2021).

    Google Scholar 

  • Strobel, N. A., Adams, C., McAullay, D. R. & Edmond, K. M. 2022 Mother’s own milk compared with formula milk for feeding preterm or low birth weight infants: systematic review and meta-analysis. Pediatrics 150,= (2022).

  • Vatne, A. et al. Early empirical antibiotics and adverse clinical outcomes in infants born very preterm: a population-based cohort. J. Pediatr. 253, 107-114.e5 (2023).

    Google Scholar 

  • Batta, V. K., Rao, S. C. & Patole, S. K. Bifidobacterium infantis as a probiotic in preterm infants: a systematic review and meta-analysis. Pediatr. Res. 94, 1887–1905 (2023).

    Google Scholar 

  • Villamor-Martínez, E. et al. Probiotic supplementation in preterm infants does not affect the risk of bronchopulmonary dysplasia: a meta-analysis of randomized controlled trials. Nutrients 9, 1197 (2017).

    Google Scholar 

  • Beck, L. C. et al. Strain-specific impacts of probiotics are a significant driver of gut microbiome development in very preterm infants. Nat. Microbiol. 7, 1525–1535 (2022).

    Google Scholar 

  • Wang, Y. et al. Probiotics, prebiotics, lactoferrin, and combination products for prevention of mortality and morbidity in preterm infants: a systematic review and network meta-analysis. JAMA Pediatr. 177, 1158–1167 (2023).

    Google Scholar 

  • Martí, M. et al. Effects of Lactobacillus reuteri supplementation on the gut microbiota in extremely preterm infants in a randomized placebo-controlled trial. Cell Rep. Med. 2, 100206 (2021).

    Google Scholar 

  • Hoshiyar, A. ordPens: an R package for selection, smoothing and principal components analysis for ordinal variables. J. Open Source Softw. 6, 3828 (2021).

    Google Scholar 

Continue Reading