Author: admin

  • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144 (5), 646–674 (2011).

    Google Scholar 

  • Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (New York) 324 (5930), 1029–1033 (2009).

    Google Scholar 

  • Warburg, O. On the Origin of Cancer Cells Vol. 123, p. 309–314 (Science, 1956). 3191.

  • Koppenol, W. H., Bounds, P. L. & Dang, C. V. Otto warburg’s contributions to current concepts of cancer metabolism. Nat. Rev. Cancer. 11 (5), 325–337 (2011).

    Google Scholar 

  • Jose, C., Bellance, N. & Rossignol, R. Choosing between Glycolysis and oxidative phosphorylation: a tumor’s dilemma? Biochim. Biophys. Acta. 1807 (6), 552–561 (2011).

    Google Scholar 

  • Bonnet, S. et al. A mitochondria-K + channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell. 11 (1), 37–51 (2007).

    Google Scholar 

  • Greene, J., Segaran, A. & Lord, S. Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications. Sem. Cancer Biol. 86 (Pt 2), 851–859 (2022).

    Google Scholar 

  • Ward, P. S. & Thompson, C. B. Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell. 21 (3), 297–308 (2012).

    Google Scholar 

  • Pavlova, N. N. & Thompson, C. B. The Emerg. Hallm. Cancer Metabolism Cell. Metabolism, 23(1): 27–47. (2016).

    Google Scholar 

  • Dang, C. V. MYC on the path to cancer. Cell 149 (1), 22–35 (2012).

    Google Scholar 

  • Zong, W. X., Rabinowitz, J. D. & White, E. Mitochondria Cancer Mol. Cell., 61(5): 667–676. (2016).

    Google Scholar 

  • Sancho, P. et al. MYC/PGC-1α balance determines the metabolic phenotype and plasticity of pancreatic cancer stem cells. Cell Metabol. 22 (4), 590–605 (2015).

    Google Scholar 

  • Vlashi, E. & Pajonk, F. Cancer stem cells, cancer cell plasticity and radiation therapy. Sem. Cancer Biol. 31, 28–35 (2015).

    Google Scholar 

  • Fendt, S. M., Frezza, C. & Erez, A. Targeting metabolic plasticity and flexibility dynamics for cancer therapy. Cancer Discov. 10 (12), 1797–1807 (2020).

    Google Scholar 

  • Kreuzaler, P. et al. Adapt and conquer: metabolic flexibility in cancer growth, invasion and evasion. Mol. Metabolism, 33. 83-101 (2020). doi:10.1016/j.molmet.2019.08.021

  • Bailleul, J. & Vlashi, E. Glioblastomas: Hijacking Metabolism To Build a Flexible Shield for Therapy Resistance Vol. 39, p. 957–979 (Antioxidants & Redox Signaling, 2023). 13–15.

  • Obre, E. & Rossignol, R. Emerging concepts in bioenergetics and cancer research: metabolic flexibility, coupling, symbiosis, switch, oxidative tumors, metabolic remodeling, signaling and bioenergetic therapy. Int. J. Biochem. Cell Biol. 59, 167–181 (2015).

    Google Scholar 

  • Yang, B. & Shi, J. Chemistry of Advanced Nanomedicines in Cancer Cell Metabolism Regulation. Adv. Sci. (Weinheim Baden-Wurttemberg Germany). 7 (18), p2001388 (2020).

    Google Scholar 

  • Luo, Z. et al. Targeting cancer metabolic pathways for improving chemotherapy and immunotherapy. Cancer Lett. 575, 216396 (2023).

    Google Scholar 

  • Weinberg, S. E. & Chandel, N. S. Targeting mitochondria metabolism for cancer therapy. Nat. Chem. Biol. 11, 9-15 (2015). doi:10.1038/nchembio.1712

  • Sabharwal, S. S. & Schumacker, P. T. Mitochondrial ROS in cancer: initiators, amplifiers or an achilles’ heel? Nat. Rev. Cancer. 14 (11), 709–721 (2014).

    Google Scholar 

  • Brown, J. M. & Wilson, W. R. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer. 4 (6), 437–447 (2004).

    Google Scholar 

  • Minchinton, A. I. & Tannock, I. F. Drug penetration in solid tumours. Nat. Rev. Cancer. 6 (8), 583–592 (2006).

    Google Scholar 

  • Vlashi, E. et al. Metabolic state of glioma stem cells and nontumorigenic cells. Proc. Natl. Acad. Sci. U.S.A. 108 (38), 16062–16067 (2011).

    Google Scholar 

  • Batlle, E. & Clevers, H. Cancer stem cells revisited. Nat. Med. 23 (10), 1124–1134 (2017).

    Google Scholar 

  • Janiszewska, M. et al. Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells. Genes Dev. 26 (17), 1926–1944 (2012).

    Google Scholar 

  • Viale, A. et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514 (7524), 628–632 (2014).

    Google Scholar 

  • Molina, J. R. et al. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat. Med. 24 (7), 1036–1046 (2018).

    Google Scholar 

  • Baran, N. et al. Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia. Nat. Commun. 13 (1), 2801 (2022).

    Google Scholar 

  • Zhou, Y. et al. Recent advances of mitochondrial complex I inhibitors for cancer therapy: current status and future perspectives. Eur. J. Med. Chem. 251, 115219 (2023).

    Google Scholar 

  • Al Assi, A. et al. A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity. Cell Death Dis. 15 (5), 311 (2024).

    Google Scholar 

  • Basit, F. et al. Mitochondrial complex I Inhibition triggers a mitophagy-dependent ROS increase leading to necroptosis and ferroptosis in melanoma cells. Cell Death Dis. 8 (3), e2716 (2017).

    Google Scholar 

  • Yap, T. A. et al. Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials. Nat. Med. 29 (1), 115–126 (2023).

    Google Scholar 

  • Tufail, M., Jiang, C. H. & Li, N. Altered metabolism in cancer: insights into energy pathways and therapeutic targets. Mol. Cancer. 23 (1), 203 (2024).

    Google Scholar 

  • Gao, X. et al. Inhibition of Mitochondria NADH-Ubiquinone Oxidoreductase (complex I) Sensitizes the Radioresistant Glioma U87MG Cells To Radiation Vol. 129, p. 110460 (Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 2020).

  • Hess-Stumpp, H. J. C. R. Abstract LB-244: BAY 87-2243, an inhibitor of HIF-1α-induced gene activation, showed promising anti-tumor efficacy in combination with anti-angiogenic therapy and irradiation in preclinical tumor models. Cancer Res. 72 (8_Supplement), LB-244-LB-244 (2012).

    Google Scholar 

  • Ashton, T. M. et al. Oxidative phosphorylation as an emerging target in cancer therapy. Clin. Cancer Research: Official J. Am. Association Cancer Res. 24 (11), 2482–2490 (2018).

    Google Scholar 

  • Liu, Z. et al.Synergistic Antitumor Effect of Combined Radiotherapy and Engineered Salmonella typhimurium in an Intracranial Sarcoma Mouse Model. Vaccines 11 (7), (2023).

  • Tran, T. A. T. et al. Natural killer cell therapy potentially enhances the antitumor effects of bevacizumab plus Irinotecan in a glioblastoma mouse model. Front. Immunol. 13, 1009484 (2022).

    Google Scholar 

  • Smilowitz, H. M. et al. Increasing radiation dose improves immunotherapy outcome and prolongation of tumor dormancy in a subgroup of mice treated for advanced intracerebral melanoma. Cancer Immunol. Immunotherapy: CII. 65 (2), 127–139 (2016).

    Google Scholar 

  • Lan, X. Y. et al. Unlocking the potential of Ultra-High dose fractionated radiation for effective treatment of glioblastoma in mice. J. Cancer. 15 (13), 4060–4071 (2024).

    Google Scholar 

  • Zarghami, N. et al. Half brain irradiation in a murine model of breast cancer brain metastasis: magnetic resonance imaging and histological assessments of dose-response. Radiation Oncol. (London England). 13 (1), 104 (2018).

    Google Scholar 

  • Zanoni, M. et al. Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma. Cell Death Dis. 13 (1), 80 (2022).

    Google Scholar 

  • Jin, L. et al. The ROS/AKT/S6K axis induces corneal epithelial dysfunctions under LED blue light exposure. Ecotoxicol. Environ. Saf. 287, 117345 (2024).

    Google Scholar 

  • Jiang, J. et al. Catechin Promotes Endoplasmic Reticulum stress-mediated Gastric Cancer Cell Apoptosis Via NOX4-induced Reactive Oxygen Species (Molecular and Cellular Biochemistry, 2024).

  • DeBerardinis, R. J. et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metabol. 7 (1), 11–20 (2008).

    Google Scholar 

  • Zong, Y. et al. Mitochondrial dysfunction: mechanisms and advances in therapy. Signal. Transduct. Target. Therapy. 9 (1), 124 (2024).

    Google Scholar 

  • Raimondi, V., Ciccarese, F. & Ciminale, V. Oncogenic pathways and the electron transport chain: a DangeROS liaison. Br. J. Cancer. 122 (2), 168–181 (2020).

    Google Scholar 

  • Perillo, B. et al. ROS in cancer therapy: the bright side of the Moon. Exp. Mol. Med. 52 (2), 192–203 (2020).

    Google Scholar 

  • Dosunmu-Ogunbi, A. M. et al. Decoding the role of SOD2 in sickle cell disease. Blood Adv. 3 (17), 2679–2687 (2019).

    Google Scholar 

  • Bastin, J. et al. Downregulation of mitochondrial complex I induces ROS production in colorectal cancer subtypes that differently controls migration. J. Translational Med. 21 (1), 522 (2023).

    Google Scholar 

  • Hubackova, S. et al. Mitochondria-driven elimination of cancer and senescent cells. Biol. Chem. 400 (2), 141–148 (2019).

    Google Scholar 

  • Martínez-Reyes, I. & Chandel, N. S. Mitochondrial TCA cycle metabolites control physiology and disease. Nat. Commun. 11 (1), 102 (2020).

    Google Scholar 

  • Martell, E. et al. Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 Medulloblastoma. Nat. Commun. 14 (1), 2502 (2023).

    Google Scholar 

  • Zhang, Z. et al. Redox signaling in drug-tolerant persister cells as an emerging therapeutic target. EBioMedicine 89, 104483 (2023).

    Google Scholar 

  • Ivashkevich, A. et al. Use of the γ-H2AX assay to monitor DNA damage and repair in translational cancer research. Cancer Lett. 327 (1–2), 123–133 (2012).

    Google Scholar 

  • Guo, C. et al. Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regeneration Res. 8 (21), 2003–2014 (2013).

    Google Scholar 

  • Borodkina, A. et al. Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging 6 (6), 481–495 (2014).

    Google Scholar 

  • Stiff, T. et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64 (7), 2390–2396 (2004).

    Google Scholar 

  • Alarifi, S. et al. Regulation of apoptosis through bcl-2/bax proteins expression and DNA damage by nano-sized gadolinium oxide. Int. J. Nanomed. 12, 4541–4551 (2017).

    Google Scholar 

  • Kalkavan, H. & Green, D. R. MOMP, cell suicide as a BCL-2 family business. Cell Death Differ. 25 (1), 46–55 (2018).

    Google Scholar 

  • Chipuk, J. E. & Green, D. R. How do BCL-2 proteins induce mitochondrial outer membrane permeabilization? Trends Cell Biol. 18 (4), 157–164 (2008).

    Google Scholar 

  • Wang, C. & Youle, R. J. The role of mitochondria in apoptosis*. Annu. Rev. Genet., 43. 95-118 (2009). doi:10.1146/annurev-genet-102108-134850

  • Vyas, S., Zaganjor, E. & Haigis, M. C. Mitochondria Cancer Cell., 166(3): 555–566. (2016).

    Google Scholar 

  • Porter, A. G. & Jänicke, R. U. Emerging roles of caspase-3 in apoptosis. Cell Death Differ., 6, 99-104 (1999). doi:10.1038/sj.cdd.4400476

  • Ferreira, K. S. et al. Caspase-3 feeds back on caspase-8, bid and XIAP in type I Fas signaling in primary mouse hepatocytes. Apoptosis: Int. J. Program. Cell. Death. 17 (5), 503–515 (2012).

    Google Scholar 

  • Diepart, C. et al. Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors. Cancer Res. 72 (2), 482–490 (2012).

    Google Scholar 

  • Park, Y. Y. et al. ATP Depletion during Mitotic Arrest Induces Mitotic Slippage and APC/CCdh1-dependent Cyclin B1 Degradation Vol. 50 (Experimental & Molecular Medicine, 2018). 4.

  • Hoeijmakers, J. H. J. DNA damage, aging, and cancer. N. Engl. J. Med. 361 (15), 1475–1485 (2009).

    Google Scholar 

  • Sancar, A. et al. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu. Rev. Biochem. 73, 39–85 (2004).

    Google Scholar 

  • McCann, E., O’Sullivan, J. & Marcone, S. Targeting cancer-cell mitochondria and metabolism to improve radiotherapy response. Translational Oncol. 14 (1), 100905 (2021).

    Google Scholar 

  • Engeland, K. Cell cycle regulation: p53-p21-RB signaling. Cell Death Differ. 29 (5), 946–960 (2022).

    Google Scholar 

  • Zheng, X. X. et al. Mitochondria in cancer stem cells: Achilles heel or hard armor. Trends Cell Biol. 33 (8), 708–727 (2023).

    Google Scholar 

  • Fan, M. et al. Cancer stem cell fate determination: mito-nuclear communication. Cell. Communication Signaling: CCS. 21 (1), 159 (2023).

    Google Scholar 

  • Fleury, C., Mignotte, B. & Vayssière, J. L. Mitochondrial reactive oxygen species in cell death signaling. Biochimie 84 (2–3), 131–141 (2002).

    Google Scholar 

  • Stine, Z. E. et al. Targeting cancer metabolism in the era of precision oncology. Nat. Rev. Drug Discov. 21 (2), 141–162 (2022).

    Google Scholar 

  • Xu, Y. et al. Why all the fuss about oxidative phosphorylation (OXPHOS)? J. Med. Chem. 63 (23), 14276–14307 (2020).

    Google Scholar 

Continue Reading

  • Japan’s Two-Year Bond Sale Demand Weaker Than 12-Month Average – Bloomberg.com

    1. Japan’s Two-Year Bond Sale Demand Weaker Than 12-Month Average  Bloomberg.com
    2. Japanese government bonds edge lower ahead of 40-year debt auction  Business Recorder
    3. Benchmark JGB yields rise on issuance shuffle; 2-year notes stable before auction  TradingView
    4. Japan’s 40-Year Bond Sale Demand Slightly Higher Than Average  Bloomberg.com
    5. JGB Yields Higher After Strong Tokyo Inflation Data  The Wall Street Journal

    Continue Reading

  • Hong Kong firefighters make final search, apartment tower blaze kills 94

    Hong Kong firefighters make final search, apartment tower blaze kills 94

    HONG KONG — Hong Kong firefighters combed through a high-rise apartment complex apartment-by-apartment Friday in a final attempt to find anyone alive after a massive fire engulfed seven of eight towers, killing at least 94 people in one of the…

    Continue Reading

  • Baikonur Cosmodrome in Kazakhstan damaged after Russia’s ‘Soyuz’ launch to the International Space Station

    Baikonur Cosmodrome in Kazakhstan damaged after Russia’s ‘Soyuz’ launch to the International Space Station

    Russia’s Roscosmos space agency reported on Nov. 27 that the launch pad at the Baikonur Cosmodrome in Kazakhstan sustained damage during the Soyuz MS-28 liftoff to the International Space Station.

    Although the spacecraft carrying two Russian…

    Continue Reading

  • Part of Bangkok’s Lat Krabang district declared rabies zone

    Part of Bangkok’s Lat Krabang district declared rabies zone

    The declaration warns owners of animals or animal carcasses within the rabies zone to strictly adhere to the guidelines outlined in the act:

     • No one shall move a dog or animal carcass within the area or move it in or out of the area unless…

    Continue Reading

  • Samsung Galaxy Buds 3 Pro vs. Apple AirPods Pro 3: I listened to both models, and this pair wins

    Samsung Galaxy Buds 3 Pro vs. Apple AirPods Pro 3: I listened to both models, and this pair wins

    Christian de Looper/ZDNET

    Follow ZDNET: Add us as a preferred source on Google.


    The first-party advantage is real. 

    The most obvious example of why first-party products are worth considering is the AirPods lineup, led by the latest AirPods…

    Continue Reading

  • Microsoft unveils Fara-7B, a lightweight AI model that can use a PC from a single screenshot – The Indian Express

    1. Microsoft unveils Fara-7B, a lightweight AI model that can use a PC from a single screenshot  The Indian Express
    2. Fara-7B: An Efficient Agentic Model for Computer Use  Microsoft
    3. Meet Fara-7B, Microsoft’s AI agent that blows OpenAI’s GPT-4o away  

    Continue Reading

  • Earliest hidden sign of zinc deficiency and 5 foods that help restore healthy level |

    Earliest hidden sign of zinc deficiency and 5 foods that help restore healthy level |

    Zinc has become a growing point of scientific and public interest because it plays a role in processes that are central to everyday wellbeing. It supports immune function, tissue repair, cell growth, and sensory perception, yet it is easy for…

    Continue Reading

  • Global wellness expert reveals 10 ways to boost digestive health

    Global wellness expert reveals 10 ways to boost digestive health

    Improving digestion involves not just what goes onto the plate but how, when, and in what state it’s eaten. Functional medicine doctors, like Dr. Eric Berg, often discuss such simple daily habits that can turn bloating, gas, heaviness, and…

    Continue Reading

  • NIZO and University of Twente partner on lab device to test how food affects brain health

    NIZO and University of Twente partner on lab device to test how food affects brain health

    Dutch food research organization NIZO and the University of Twente have announced a strategic partnership to commercialize the Gut-Brain Axis on Chip, a laboratory device that mimics how the human gut and brain communicate. The technology allows…

    Continue Reading