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  • Fake News Watchdog dismantles India’s space mission claims

    Fake News Watchdog dismantles India’s space mission claims

    An explosive new report from the Fake News Watchdog has cast a shadow of doubt over the authenticity of India’s much-publicised Chandrayaan-3 lunar mission.

    The 65-page white paper, released recently, claims that the mission was largely a media spectacle rather than a scientific achievement.

    The watchdog reported that live visuals of the moon landing, which were broadcast to millions worldwide, were created using computer-generated graphics (CGI).

    The “live” footage of Chandrayaan-3’s descent and landing was, according to the report, fabricated and presented within a staged environment.

    The command centre scenes shown on national television were also described as being choreographed, giving viewers the impression of a high-stakes space mission.

    The report raises concerns about the transparency of the Indian Space Research Organisation (ISRO) and challenges the space agency’s claim of landing at the Moon’s south pole.

    Read: India’s satellite launch fails after technical fault in PSLV rocket

    The watchdog contends that the actual landing site was 630 kilometers away from the claimed location.

    Moreover, Chandrayaan-3’s mission reportedly failed to deliver scientific data or post-landing rover footage, with alleged faults in the lander’s navigation system and mechanical limitations preventing the rover from operating as claimed.

    International experts, particularly from China, have questioned the scientific validity of the mission, calling into doubt the authenticity of ISRO’s findings.

    The report criticizes India’s use of the space programme for political purposes, rather than genuine scientific exploration, alleging that the mission served as a tool for regional posturing and image-building.

    Pro-government media in India, according to the report, presented the mission as a triumph of national pride without providing verifiable results.

    Furthermore, the report highlights India’s broader military ambitions in space, linking the Chandrayaan-3 mission to defence objectives.

    The watchdog accuses the ruling Bharatiya Janata Party (BJP) government of leveraging ISRO’s advancements for military purposes, especially in its rivalry with Pakistan and China.

    Read More: India achieves space docking milestone with SpaDeX mission

    The paper references India’s 2019 anti-satellite test, “Mission Shakti”, and the establishment of military institutions like the Defence Space Agency (DSA) as evidence of militarisation of space.

    The report also sheds light on India’s satellite programme, revealing that 10 out of the country’s 56 satellites are used by the military for surveillance, navigation and communication during operations like “Operation Sindoor”.

    It criticises the Indian government’s “Space Vision 2047” and “Make in India” initiatives, labelling them as propaganda tools to foster a brand of technological nationalism rather than serving public interest.

    While India’s defence budget has surpassed $86 billion – nearly nine times the size of Pakistan’s – the report underscores the stark contrast between this investment and the fact that over 300 million Indians still lack access to necessities such as clean water, electricity and sanitation.

    The report concludes by accusing India’s media of using artificial intelligence (AI) to manipulate national narratives and promote fake news, a practice that has backfired on global platforms.

    The Fake News Watchdog claims that India’s space missions, including Chandrayaan-3, are primarily for political optics, raising serious concerns about the country’s space programme’s ethics, transparency and intent.

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  • Exclusive: Santander bid would value tsb at more than $3.2 billion, source says – Reuters

    1. Exclusive: Santander bid would value tsb at more than $3.2 billion, source says  Reuters
    2. Santander, Barclays Said to Be Final Bidders for Sabadell’s TSB  Bloomberg
    3. Santander among bidders for Sabadell’s TSB unit By Investing.com  Investing.com UK
    4. Banco Sabadell Considers Offers for UK Unit TSB  PYMNTS.com
    5. Santander and Barclays in race to acquire TSB  Sharecast News

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  • Spain records highs of 46C and France under alert as Europe swelters in heatwave | Europe weather

    Spain records highs of 46C and France under alert as Europe swelters in heatwave | Europe weather

    A vicious heatwave has engulfed southern Europe, with punishing temperatures that have reached highs of 46C (114.8F) in Spain and placed almost the entirety of mainland France under alert.

    Extreme heat, made stronger by fossil fuel pollution, has for several days scorched Portugal, Spain, France, Italy and Greece as southern Europe endures its first major heatwave of the summer.

    The high temperatures have prompted the authorities in several countries to issue new health warnings and scramble firefighters to prevent wildfires from breaking out. More than 50,000 people in Turkey have been evacuated from their homes due to forest fires, according to the interior ministry’s disaster and emergency management authority.

    António Guterres, the UN secretary general, said at a development conference in Seville on Monday: “Extreme heat is no longer a rare event – it has become the new normal.”

    People queue at a fountain during a heatwave in Saint Peter’s Square, Vatican City. Photograph: Angelo Carconi/EPA

    In Portugal — his home country — a reading of 46.6 C (115.9F) was registered in Mora, about 60 miles east of Lisbon. Weather officials were working to confirm whether that marked a new record for June.

    The southern Spanish city is forecast to roast in more than 40C heat for the next three days and face night-time temperatures of at least 25C until Thursday morning. Doctors have expressed alarm at the combination of hot days and uncomfortably warm nights, which can place a lethal stress on the human body.

    In Italy, where 21 out of 27 cities were placed on the highest heat alert on Sunday, hospital admissions in some of the hottest regions – such as Tuscany – are up 20%. People have been advised not to venture outside between 11am and 6pm.

    In France, heat warnings covered nearly the entire mainland for the first time in history. Météo-France has placed 88% of administrative areas under the second-highest orange heat alerts. “This is unprecedented,” said the ecology minister, Agnès Pannier-Runacher.

    A wildfire broke out in Bizanet, southern France. Photograph: Ed Jones/AFP/Getty Images

    The French government asked businesses to adapt staff hours to protect workers from the heat, and 200 public schools are to be partly or totally closed on Monday and Tuesday. The first fire of the summer broke out in France in the south-west of the country at the weekend, burning 400 hectares and leading to the precautionary evacuation of more than 100 people from their homes.

    In Spain, which has had the worst of the weather, a June temperature record of 46C was set on Saturday afternoon in El Granado, in the Andalucían province of Huelva. The highest temperature previously recorded for June was 45.2C logged in Seville in 1965.

    Sunday was the hottest 29 June in Spain on record, according to records from Aemet, the Spanish meteorological agency, that stretch back to 1950. The heat is expected to last till Thursday.

    A woman takes to the shade the Retiro park in Madrid, Spain. Photograph: Paul White/AP

    In Portugal, where seven of 18 regions are under red warnings of “extreme risk”, meteorologists expect the weather to cool down on Wednesday night.

    Countries farther north are also in danger. The German weather service has said heat and dry weather are stoking the risk of forest fires, with some cities imposing limits on water extraction as temperatures in parts of the country approach 40C by Wednesday.

    In Brandenburg, the state surrounding Berlin, the government has urged employers to take the danger to their staff into account. “Companies are bound by heat protection rules at the workplace,” the regional health minister Britta Müller said, including maintaining an acceptable temperature indoors and guarding against excessive sun exposure.

    The UK is projected to have temperatures of 34C in London and the south-east of England, with the Met Office warning that high temperatures and humid conditions will be “quite uncomfortable” for those working outside, as well as people leaving Glastonbury and attending the start of Wimbledon.

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    Radhika Khosla, an urban climatologist at the University of Oxford, said: “Populations in urban areas like London are particularly susceptible to extreme heat as the concrete and asphalt absorb and re-emit the sun’s radiation, amplifying its impact on our bodies. For this reason, outdoor workers are particularly at risk and should take regular breaks to hydrate in the shade.”

    Wildfires rage across Turkey’s Izmir province – video report

    The International Federation of Red Cross and Red Crescent Societies said its teams were supporting responders who were battling fires in Turkey, Greece and Norway. In other countries such as Spain, Italy and the UK, its volunteers were handing out water and checking in on vulnerable people.

    Heat kills an estimated half a million people globally each year, with older people and those with chronic illness particularly vulnerable.

    The extreme temperatures across Europe are a result of a heat dome that is trapping an area of high pressure and hot air – a phenomenon that is also currently scorching the US. It comes amid an ongoing marine heatwave that has left the Mediterranean 5C hotter than normal, according to data from the University of Maine’s climate change institute.

    Dr Michael Byrne, a climate scientist at the University of St Andrews, said heat domes were nothing new but the temperatures they delivered were. “Europe is more than 2C warmer than in preindustrial times, so when a heat dome occurs it drives a hotter heatwave,” he said.

    Doctors across the continent warned people to take extra care in the hot weather, encouraging them to stay out of the heat, drink lots of water, wear loose clothing and check in on vulnerable neighbours.

    Researchers estimate that dangerous temperatures in Europe will kill 8,000 to 80,000 more people by the end of the century, as the lives lost to stronger heat outpace those saved from milder cold.

    “The planet is getting hotter and more dangerous,” said Guterres, who called for more action to stop climate change. “No country is immune.”

    Additional reporting from Angelique Chrisafis in Paris, Angela Giuffrida in Rome and Deborah Cole in Berlin

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  • 935 people killed in Israeli strikes on Iran, official says – Reuters

    1. 935 people killed in Israeli strikes on Iran, official says  Reuters
    2. What are the death tolls in Iran, Israel from their war?  Dawn
    3. Martyrdom of 935 people in the Zionist Regime’s attacks  خبرگزاری میزان
    4. At least 935 people killed in Israeli attacks during 12-day conflict: Iran  TRT Global
    5. Iran raises death toll from war with Israel to more than 900  WTNH.com

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  • IMAX Races to $28 Million Opening Weekend for “F1®: The Movie” – Business Wire

    1. IMAX Races to $28 Million Opening Weekend for “F1®: The Movie”  Business Wire
    2. ‘F1’ races to $140M global debut, sets box office record for Brad Pitt and Apple Original Films  The Express Tribune
    3. Brad Pitt’s ‘F1’ cruises to top of N.America box office  Business Recorder
    4. ‘F1’ opens with $55 million, delivering Apple its biggest big-screen hit  Dunya News
    5. Why did it take Jerry Bruckheimer three years to get F1’s approval?  ARY News

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  • 2-time Wimbledon finalist Ons Jabeur quits during 1st match

    2-time Wimbledon finalist Ons Jabeur quits during 1st match

    LONDON (AP) — Two-time Wimbledon runner-up Ons Jabeur retired during her first-round match Monday after taking a medical timeout, the latest issue for her during an injury-filled season.

    Jabeur, a 30-year-old from Tunisia, quit playing while trailing Viktoriya Tomova 7-6 (5), 2-0.

    Jabeur was visited by a trainer in the first set. At one point, she sat on her sideline seat and cried into a towel.

    “I wasn’t expecting not to feel good. I have been practicing pretty well the last few days. But I guess these things happen,” Jabeur said afterward. “I’m pretty sad. Doesn’t really help me with my confidence and what I keep pushing myself to do even though it was a very tough season for me. I hope I can feel better.”

    She lost to Elena Rybakina in the 2022 final and to Marketa Vondrousova in the 2023 final. Jabeur also was a finalist at the 2022 U.S. Open, losing to Iga Swiatek.

    Jabeur’s 2024 season ended early because of a shoulder injury and she’s dealt with leg problems this year.

    ___

    AP tennis: https://apnews.com/hub/tennis


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  • Wimbledon 2025: Full order of play, 1 July

    Wimbledon 2025: Full order of play, 1 July

    Reigning women’s singles champion Barbora Krejcikova begins her title defence on Tuesday, 1 July at Wimbledon 2025 (30 June-13 July).

    The Olympic tennis gold medallist opens on Centre Court in a bid for her third major singles title, having defeated fellow Olympic champion Jasmine Paolini in the 2024 final.

    Krejcikova takes on rising Filipina star Alexandra Eala, who makes her main draw debut at SW19 on the grandest stage and her dream court.

    Men’s world No.1 Jannik Sinner opens No.1 Court in an all-Italian battle against Luca Nardi, as the 23-year-old aims for his first trophy since the 2025 Australian Open.

    Among the big names in action are seven-time Wimbledon champion Novak Djokovic, Roland-Garros winner Coco Gauff and British No.1 Jack Draper.

    Read on to find out the start times and how to watch the Championships live by scrolling over to 1 July below.

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  • How can the James Webb Space Telescope see so far?

    How can the James Webb Space Telescope see so far?

    Curious Kids is a series for children of all ages. If you have a question you’d like an expert to answer, send it to CuriousKidsUS@theconversation.com.


    How does the camera on the James Webb Space Telescope work and see so far out? – Kieran G., age 12, Minnesota


    Imagine a camera so powerful it can see light from galaxies that formed more than 13 billion years ago. That’s exactly what NASA’s James Webb Space Telescope is built to do.

    Since it launched in December 2021, Webb has been orbiting more than a million miles from Earth, capturing breathtaking images of deep space. But how does it actually work? And how can it see so far? The secret lies in its powerful cameras – especially ones that don’t see light the way our eyes do.

    I’m an astrophysicist who studies galaxies and supermassive black holes, and the Webb telescope is an incredible tool for observing some of the earliest galaxies and black holes in the universe.

    When Webb takes a picture of a distant galaxy, astronomers like me are actually seeing what that galaxy looked like billions of years ago. The light from that galaxy has been traveling across space for the billions of years it takes to reach the telescope’s mirror. It’s like having a time machine that takes snapshots of the early universe.

    By using a giant mirror to collect ancient light, Webb has been discovering new secrets about the universe.

    A telescope that sees heat

    Unlike regular cameras or even the Hubble Space Telescope, which take images of visible light, Webb is designed to see a kind of light that’s invisible to your eyes: infrared light. Infrared light has longer wavelengths than visible light, which is why our eyes can’t detect it. But with the right instruments, Webb can capture infrared light to study some of the earliest and most distant objects in the universe.

    A dog, shown normally, then through thermal imaging, with the eyes, mouth and ears brighter than the rest of the dog.
    Infrared cameras, like night-vision goggles, allow you to ‘see’ the infrared waves emitting from warm objects such as humans and animals. The temperatures for the images are in degrees Fahrenheit.
    NASA/JPL-Caltech

    Although the human eye cannot see it, people can detect infrared light as a form of heat using specialized technology, such as infrared cameras or thermal sensors. For example, night-vision goggles use infrared light to detect warm objects in the dark. Webb uses the same idea to study stars, galaxies and planets.

    Why infrared? When visible light from faraway galaxies travels across the universe, it stretches out. This is because the universe is expanding. That stretching turns visible light into infrared light. So, the most distant galaxies in space don’t shine in visible light anymore – they glow in faint infrared. That’s the light Webb is built to detect.

    A diagram of the electromagnetic spectrum, with radio, micro and infrared waves having a longer wavelength than visible light, while UV, X-ray and gamma rays have shorter wavelengths than visible light.
    The rainbow of visible light that you can see is only a small slice of all the kinds of light. Some telescopes can detect light with a longer wavelength, such as infrared light, or light with a shorter wavelength, such as ultraviolet light. Others can detect X-rays or radio waves.
    Inductiveload, NASA/Wikimedia Commons, CC BY-SA

    A golden mirror to gather the faintest glow

    Before the light reaches the cameras, it first has to be collected by the Webb telescope’s enormous golden mirror. This mirror is over 21 feet (6.5 meters) wide and made of 18 smaller mirror pieces that fit together like a honeycomb. It’s coated in a thin layer of real gold – not just to look fancy, but because gold reflects infrared light extremely well.

    The mirror gathers light from deep space and reflects it into the telescope’s instruments. The bigger the mirror, the more light it can collect – and the farther it can see. Webb’s mirror is the largest ever launched into space.

    The JWST's mirror, which looks like a large, roughly hexagonal shiny surface made up of 18 smaller hexagons put together, sitting in a facility. The mirror is reflecting the NASA meatball logo.
    Webb’s 21-foot primary mirror, made of 18 hexagonal mirrors, is coated with a plating of gold.
    NASA

    Inside the cameras: NIRCam and MIRI

    The most important “eyes” of the telescope are two science instruments that act like cameras: NIRCam and MIRI.

    NIRCam stands for near-infrared camera. It’s the primary camera on Webb and takes stunning images of galaxies and stars. It also has a coronagraph – a device that blocks out starlight so it can photograph very faint objects near bright sources, such as planets orbiting bright stars.

    NIRCam works by imaging near-infrared light, the type closest to what human eyes can almost see, and splitting it into different wavelengths. This helps scientists learn not just what something looks like but what it’s made of. Different materials in space absorb and emit infrared light at specific wavelengths, creating a kind of unique chemical fingerprint. By studying these fingerprints, scientists can uncover the properties of distant stars and galaxies.

    MIRI, or the mid-infrared instrument, detects longer infrared wavelengths, which are especially useful for spotting cooler and dustier objects, such as stars that are still forming inside clouds of gas. MIRI can even help find clues about the types of molecules in the atmospheres of planets that might support life.

    Both cameras are far more sensitive than the standard cameras used on Earth. NIRCam and MIRI can detect the tiniest amounts of heat from billions of light-years away. If you had Webb’s NIRCam as your eyes, you could see the heat from a bumblebee on the Moon. That’s how sensitive it is.

    Two photos of space, with lots of stars and galaxies shown as little dots. The right image shows more, brighter dots than the left.
    Webb’s first deep-field image: The MIRI image is on the left and the NIRCam image is on the right.
    NASA

    Because Webb is trying to detect faint heat from faraway objects, it needs to keep itself as cold as possible. That’s why it carries a giant sun shield about the size of a tennis court. This five-layer sun shield blocks heat from the Sun, Earth and even the Moon, helping Webb stay incredibly cold: around -370 degrees F (-223 degrees C).

    MIRI needs to be even colder. It has its own special refrigerator, called a cryocooler, to keep it chilled to nearly -447 degrees F (-266 degrees C). If Webb were even a little warm, its own heat would drown out the distant signals it’s trying to detect.

    Turning space light into pictures

    Once light reaches the Webb telescope’s cameras, it hits sensors called detectors. These detectors don’t capture regular photos like a phone camera. Instead, they convert the incoming infrared light into digital data. That data is then sent back to Earth, where scientists process it into full-color images.

    The colors we see in Webb’s pictures aren’t what the camera “sees” directly. Because infrared light is invisible, scientists assign colors to different wavelengths to help us understand what’s in the image. These processed images help show the structure, age and composition of galaxies, stars and more.

    By using a giant mirror to collect invisible infrared light and sending it to super-cold cameras, Webb lets us see galaxies that formed just after the universe began.


    Hello, curious kids! Do you have a question you’d like an expert to answer? Ask an adult to send your question to CuriousKidsUS@theconversation.com. Please tell us your name, age and the city where you live.

    And since curiosity has no age limit – adults, let us know what you’re wondering, too. We won’t be able to answer every question, but we will do our best.

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  • Netflix Stages Massive ‘Squid Game’ Parade in Seoul

    Netflix Stages Massive ‘Squid Game’ Parade in Seoul

    Could all this really be for one TV show?

    On a humid, hazy night in Seoul over the weekend, Netflix staged its most extravagant fan event to date — a full-scale victory parade celebrating the final season of Squid Game, the candy-colored death drama that remains the company’s most-watched title of all time.

    Stretching nearly a mile, the spectacle featured over 450 performers, airborne displays of Squid Game iconography, phalanxes of pink-suited guards, a brass marching band blasting the show’s eerie anthems, and a 25-foot-tall Young-hee doll with laser beams shooting from its eyes. The procession began at the city’s historic Gwanghwamun Gate and marched into Seoul Plaza, culminating in a massive fan celebration starring Squid Game creator Hwang Dong-hyuk and 25 of the most popular cast members from across the show’s three seasons. Netflix says the event took nearly a year to organize in collaboration with the Seoul Metropolitan Government, and that the crowd surrounding the parade swelled to as many as 38,000.

    On the ground in Seoul, the moment felt so improbably outsized that it was hard not to impute broader narratives to the spectacle. Perhaps this was more about Netflix finally throwing itself a victory parade for its decisive triumph over the legacy studios in what was once cringingly referred to as “the streaming wars”? Or, thinking “local first” — as Netflix always does with its international content strategy — maybe the Netflix logo beaming over Seoul City Hall was just the natural end point of a U.S. tech giant’s full-scale takeover of the Korean entertainment industry, coyly disguised as an act of benevolence? At other moments in the evening — which included immersive video projections, star Q&As, dance sequences, an a cappella rendition of the Squid Game theme, and the crowd constantly going nuts — the celebration had the air of a raucous music festival. One where every band and DJ was Squid Game.

    However jaundiced the perspective of the sole trade reporter in attendance, though, the vibe among the stars on stage and the legions of fans who turned out for the party was purely joyous.

    ‘Squid Game’ creator Hwang Dong-hyuk and star Lee Jung-jae, along with other cast.

    “This has been a five- or six-year journey for me and I have so many fond memories,” Lee Jung-jae, who plays Squid Game protagonist Seong Gi-hun, aka Player 456, said from the stage. “I’ve been doing promotion and interviews in many countries [these past weeks], but watching the parade just now, it finally started sinking in that this is the finale and it’s all over,” he said. “I’m very grateful.”

    Actor Lee Byung-hun, who plays Squid Game‘s mysterious villain, the Front Man, said he initially signed up for the project believing he would just be shooting a brief cameo to conclude the show’s first season. But after that season became a global phenomenon, he realized his journey was just beginning.

    “When seasons two and three were greenlit, I realized I had to dig deep and understand the role — and that’s when I fell in love with this character,” Lee said. And although he’s been one of Korea’s biggest stars for over two decades, Lee said the Netflix hit held special significance in his long career. “Squid Game made history for Korean entertainment and being part of that has been an incredible honor,” he added.

    Fans in the crowd at Netflix’s ‘Squid Game’ fan event in Seoul on Saturday.

    Content creator Brian Skabeche traveled from Mexico to South Korea for Saturday’s event. Once in Seoul, he participated in a contest of Squid Game-themed challenges with over 100 international influencers and won the honor of being among 20 to walk in the parade in Young-hee’s shadow.

    “There are people who came here from all over the world and it’s been a fantastic experience,” Skabeche told THR early in the night. “One guy told me he’s here because he likes the anti-capitalist message of Squid Game; other people are just super fans.”

    Skabeche said he had never experienced Korean content before Squid Game, but he fell in love with the show while bingeing it with his sister, after she suffered an accident and was stuck at home recovering. “We both got hooked and it became this thing we bonded over,” he said. Later, Skabeche created a YouTube video with his influencer friends of their dogs participating in a mock version of Squid Game. The video was a hit and gave his channel a significant boost.

    “It connected me with K-content fans, who I learned are a really great audience,” he said.

    The giant Young-hee doll that was wheeled through central Seoul.

    The scale of Squid Game’s success is indeed unprecedented. While Korean cinema had been building a cult following since the early 2000s, and K-pop exploded into global view as far back as 2012 with Psy’s satirical smash hit “Gangnam Style,” Squid Game astonished the world when its first season debuted on Netflix in September 2021. The show’s viewership started modestly, then snowballed into an organic regional hit before exploding into a bona fide global phenomenon. Within weeks, it became Netflix’s most-watched show of all time — a title it has never ceded. (Squid Game later also won a pair of Emmys for its creator and star — a first for the Korean industry.)

    The show’s creator, Hwang Dong-hyuk, has spoken movingly of his mixed feelings about the way his brutal satire of late-stage capitalism’s rapacious inhumanity has resonated so deeply with viewers around the world.

    Netflix, naturally, has only accelerated its investment in Korean entertainment, carving out a decisive leadership position in the country’s premium online video sector ahead of Korea’s top local players. In 2023, the company pledged to invest $2.5 billion in Korean content over four years — more than double the total of all its prior K-content investments. The power of Netflix’s global business model was another undercurrent to Saturday’s Squid Game extravaganza — the kind of spectacle and expenditure that could only make sense for a platform with the potential to leverage localized titles across an international subscriber base stretching into the hundreds of millions (or, several times more than South Korea’s total population of 51 million).

    The runaway success of Squid Game’s first season heaped enormous pressure on Hwang, who famously writes and directs every episode singlehandedly. But season two — which took a full three years to make its way back onto global screens — nonetheless delivered, setting a new Netflix record for the most views in a title’s premiere week, and eventually rising to become the platform’s third most-popular show of all time. Squid Game’s fate returned to the audience last Friday, when season three launched worldwide.

    “It was a really long journey, and I put my heart and soul into this work,” Hwang told the crowd in Seoul on Saturday. “Now that it’s all over, I have a bittersweet feeling — but I also feel a lot of relief.”

    Not long after the director and his cast made their exit, the stage’s huge video monitors flashed a “Game Over” message above the crowd. Whether Squid Game — Netflix’s most valuable piece of IP — is truly over remains to be seen. A mysterious cameo from Cate Blanchett near the end of the finale — along with widespread industry chatter about a potential deal for David Fincher to direct a spinoff — would certainly suggest otherwise. For now, Netflix is staying quiet, basking instead in what one imagines as the pink glow of Season 3’s soaring viewership stats.

    (L-R back row) Cast members for Squid Game, Seasons 1, 2 & 3: Park Sung-hoon, Yang Dong-geun, Kang Ae-shim, Jo Yu-ri, Chae Gook-hee, David Lee, Roh Jae-won, Jeon Seok-ho, T.O.P, Lee Seo-hwan, Won Ji-an, Kim Pub-lae, Kim Si-eun; (L-R front row) Lee Yoo-mi, Anupam Tripathi, Kim Joo-ryoung, Jung Ho-yeon, Park Hae-soo, director Hwang Dong-hyuk, Lee Jung-jae, Lee Byung-hun, Yim Si-wan, Kang Ha-neul, Wi Ha-jun, Park Gyu-young and Lee Jin-uk. (Getty Images)

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  • New database maps olfactory gene diversity across chordates

    New database maps olfactory gene diversity across chordates

    CORD: A Comprehensive Portal into Chordate Olfactory Receptors.

    GA, UNITED STATES, June 30, 2025 /EINPresswire.com/ — How animals sense and respond to smells plays a pivotal role in their survival, communication, and evolution. Recently, a groundbreaking online database has compiled the most expansive collection of olfactory receptor (OR) genes ever assembled in chordates—animals with backbones. Encompassing over 1.1 million sequences across nearly 2,800 species, this resource offers a unified platform for exploring both functional genes and pseudogenes. It integrates advanced tools for visualizing molecular structures, mapping odor interactions, and analyzing evolutionary relationships. With its comprehensive design, the database opens new avenues for researchers to decode how animals perceive chemical cues and adapt to diverse ecological environments.

    Olfactory receptors (ORs) are key to how animals perceive their surroundings, guiding behaviors like foraging, mating, and avoiding danger. In chordates, the genes encoding these receptors are remarkably diverse and evolve rapidly, shaped by species-specific environmental pressures. Despite the explosion of genomic data in recent years, the annotation of these genes has struggled to keep pace. Many species still lack reliable OR gene catalogs, and most existing databases focus narrowly—often omitting pseudogenes or comparative frameworks. These limitations hinder the broader understanding of OR gene function and evolution. Due to these issues, a comprehensive and scalable platform for OR annotation and integration is urgently needed.

    To meet this need, researchers from ShanghaiTech University and Research Center for Life Sciences Computing, Zhejiang Lab, etc. have developed the chordata olfactory receptor database (CORD), published (DOI: 10.1093/procel/pwae050) in Protein & Cell on September 20, 2024. The online platform compiles and standardizes more than 1.1 million OR gene entries from 2,776 chordate species, offering a massive leap in the coverage, consistency, and accessibility of olfactory genomic data. By integrating functional receptors, pseudogenes, and odorant-interaction data, CORD sets a new benchmark for studying the genetic basis of smell across evolutionary lineages.

    At the heart of CORD lies Genome2OR, a high-performance gene annotation tool built on hidden Markov models. Its latest update simplifies the annotation pipeline and supports custom profiles, enabling the accurate identification of over 663,000 functional ORs and more than 513,000 pseudogenes. The database spans seven major chordate groups—from mammals and birds to jawless fish—highlighting the evolutionary richness of olfactory systems. CORD’s interface is designed with researchers in mind, featuring nine functional modules for genome browsing, structural prediction, and comparative analysis. Tools include BLAST search, sequence logos (WebLogo), and OpenFold-based 3D modeling. Users can explore complex gene–odorant relationships, supported by 3,118 receptor–ligand pairs and data on nearly 24,000 odorant compounds. Advanced visualization techniques such as snake diagrams and interactive heatmaps reveal how ORs are structured and distributed across species. Further, protein clustering datasets (CORDclust30–90) and community network analysis offer new insight into OR gene families and their evolutionary pathways. Altogether, CORD blends depth with usability, empowering researchers to unravel the biology of smell with unprecedented precision.

    Scent is one of the most ancient and intricate senses, said Dr. Suwen Zhao, one of the co-corresponding authors. Yet until now, researchers lacked a unified, scalable tool to study the extraordinary diversity of ORs in chordates. CORD fills this gap. It not only delivers a vast quantity of high-quality data, but it also makes that data discoverable and usable across disciplines—from molecular neuroscience to comparative genomics. Dr. Zhao highlighted the database’s potential to illuminate how olfactory genes function beyond the nose, impacting broader biological processes.

    With its wide-ranging data and flexible interface, CORD is poised to transform multiple research fields. Evolutionary biologists can now trace how OR gene repertoires expand and contract across ecological niches. Biomedical researchers gain a new tool to study the role of ORs in conditions like inflammation, metabolic disorders, and cancer—where these receptors are increasingly found outside the nose. In computational biology, CORD’s modular structure supports machine learning applications for modeling protein–ligand interactions. Future updates will incorporate experimentally derived OR structures, integrate AlphaFold3-based odor–receptor simulations, and launch a genome browser to map gene neighborhoods. By unifying data and tools under one roof, CORD is set to propel olfaction research into its next frontier.

    DOI
    10.1093/procel/pwae050

    Original Source URL
    https://doi.org/10.1093/procel/pwae050

    Funding information
    This work was supported by the National Key Research and Development Programs of China (2022YFA1302900, S.Z.), the National Natural Science Foundation of China (32122024, S.Z.), Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine, the Shanghai Science and Technology Plan (21DZ2260400) and ShanghaiTech University.

    Lucy Wang
    BioDesign Research
    email us here

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