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  • SecretVM and Solidity-LLM Usher in Confidential AI for Web3

    SecretVM and Solidity-LLM Usher in Confidential AI for Web3

    LOS ANGELES, Nov. 26, 2025 /PRNewswire/ — In a breakthrough that combines privacy, cryptographic integrity and intelligent automation, a purpose-built AI model for smart contract…

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  • Madueke on his ‘perfect’ first Gunners goal | Interview | News

    Madueke on his ‘perfect’ first Gunners goal | Interview | News

    Like the rest of us, Noni Madueke was all smiles at the final whistle of our Champions League win over Bayern Munich on Wednesday.

    But our winger had extra reason to celebrate, having come off the bench to score his first goal for the club after…

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  • ULA aimed to launch up to 10 Vulcan rockets this year—it will fly just once

    ULA aimed to launch up to 10 Vulcan rockets this year—it will fly just once

    Engineers traced the problem to a manufacturing defect in an insulator on the solid rocket motor, and telemetry data from all four boosters on the following flight in August exhibited “spot-on” performance, according to…

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  • Arcutis Biotherapeutics Surges 112% in 2025 Is the Rally Justified After Regulatory Milestones?

    Arcutis Biotherapeutics Surges 112% in 2025 Is the Rally Justified After Regulatory Milestones?

    • Curious whether Arcutis Biotherapeutics is actually a hidden gem or just riding the hype? You are not alone; many investors wonder if now is the time to buy or wait on the sidelines.

    • Arcutis shares have been on a tear, jumping 11.0% in the last week, a massive 57.6% over the past month, and an impressive 112.6% so far this year. This results in a 164.4% return over the last twelve months.

    • Recent headlines reflect this momentum, with news around regulatory milestones, fresh clinical trial updates, and new product launches putting Arcutis firmly in the spotlight. These stories have driven both optimism about the company’s growth prospects and big swings in risk sentiment among market watchers.

    • So how does the stock stack up on valuation? Arcutis scores a 3 out of 6 on our undervaluation checks. In the next section, I will break down what this means using different valuation methods, and there will be a discussion at the end on a smarter way to interpret valuation.

    Arcutis Biotherapeutics delivered 164.4% returns over the last year. See how this stacks up to the rest of the Biotechs industry.

    The Discounted Cash Flow (DCF) model estimates a company’s intrinsic value by projecting its future cash flows and then discounting those values back to today. This approach helps investors understand what a company’s shares might truly be worth, separate from daily market fluctuations.

    For Arcutis Biotherapeutics, the DCF uses the 2 Stage Free Cash Flow to Equity method. Currently, the company is generating Free Cash Flow (FCF) of -$45.4 million, which means it is still burning cash as it invests in growth. Analyst estimates point to rapid improvements, with FCF projected to reach $93 million in 2026 and $295.5 million by 2029. Beyond that, further growth assumptions are made to extend the picture over the next ten years, with FCF expected to rise steadily each year through 2035.

    Based on these cash flow projections, the DCF assessment arrives at an intrinsic value of $69.61 per share. This suggests the stock is roughly 55.5% undervalued relative to its current market price, leaving considerable upside potential if management can deliver on future growth.

    Result: UNDERVALUED

    Our Discounted Cash Flow (DCF) analysis suggests Arcutis Biotherapeutics is undervalued by 55.5%. Track this in your watchlist or portfolio, or discover 926 more undervalued stocks based on cash flows.

    ARQT Discounted Cash Flow as at Nov 2025

    Head to the Valuation section of our Company Report for more details on how we arrive at this Fair Value for Arcutis Biotherapeutics.

    For high-growth companies like Arcutis Biotherapeutics that are not yet profitable, the Price-to-Sales (P/S) ratio is often the preferred valuation metric. This is because sales figures are more stable and less susceptible to the large swings seen in earnings during the early stages of commercial development. This stability makes it easier to benchmark the company against peers and the broader market.

    Generally, a “normal” or fair P/S ratio for a company is influenced by its growth prospects and the risks it faces. Faster expected growth or lower risks can justify a higher multiple, while slower growth or elevated risks should mean a lower multiple. For context, Arcutis currently trades at an 11.93x P/S ratio. This is just below the biotech industry average of 12.33x, and modestly above the 9.17x average of its closest peers.

    Simply Wall St’s proprietary Fair Ratio for Arcutis is 10.66x. Unlike simple comparisons to the industry or peer averages, the Fair Ratio is designed to account for a company’s real growth potential, profitability outlook, margins, market cap, and risk profile. This results in a more tailored and accurate benchmark for valuation.

    Comparing the Fair Ratio to Arcutis’s actual P/S multiple suggests the stock is valued a little above what fundamentals and outlook imply, but not by a large margin.

    Result: ABOUT RIGHT

    NasdaqGS:ARQT PS Ratio as at Nov 2025
    NasdaqGS:ARQT PS Ratio as at Nov 2025

    PS ratios tell one story, but what if the real opportunity lies elsewhere? Discover 1435 companies where insiders are betting big on explosive growth.

    Earlier we mentioned that there’s an even better way to understand valuation. Let’s introduce you to Narratives. A Narrative is your story, the rationale and expectations you have for a company, translated into numbers like forecast revenue, profit margins, and ultimately a fair value estimate.

    Unlike traditional valuation models that just crunch numbers in isolation, Narratives tie the business’s journey and unique context directly to financial forecasts and a price target. This makes it much easier for investors to see how their beliefs about the company (such as product launches, market size, or competitive advantages) map onto real-world valuations and actionable decisions.

    You do not need to be a financial expert. Narratives are quick to create and update, and you can easily find and interact with them on Simply Wall St’s Community page, used by millions of investors around the world.

    Crucially, Narratives dynamically update when new news, earnings, or clinical trial results come in. This helps you continually compare your Fair Value to the current market Price to spot attractive entry or exit opportunities that fit your unique perspective.

    For instance, one bullish user expects accelerating adoption of ZORYVE and predicts a price target of $40 per share, while a more cautious Narrative sets fair value closer to $19. This demonstrates how different perspectives can drive very different investment decisions on Arcutis Biotherapeutics.

    Do you think there’s more to the story for Arcutis Biotherapeutics? Head over to our Community to see what others are saying!

    NasdaqGS:ARQT Community Fair Values as at Nov 2025
    NasdaqGS:ARQT Community Fair Values as at Nov 2025

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include ARQT.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Cyberpunk 2077 Records 35 Million Copies Sold As CDPR Ramps Up for Sequel

    Cyberpunk 2077 Records 35 Million Copies Sold As CDPR Ramps Up for Sequel

    It’s no wonder Cyberpunk 2 has already passed the pre-production phase and is entering full-fledged development, given that CD Projekt Red just announced that the iconic RPG just surpassed 35 million sales, reportedly, earning CDPR as much as…

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    We can’t connect to the server for this app or website at this time. There might be too much traffic or a configuration error. Try again later, or…

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  • Give the gift of more time with these Microsoft Office apps for less than $3 each

    Give the gift of more time with these Microsoft Office apps for less than $3 each

    TL;DR: Give the gift of improved productivity with Microsoft Office Professional Plus 2019 for Windows, on sale now for just $19.97 (reg. $229).


    There’s nothing more priceless than…

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  • Ocrelizumab Leads to Lower Hospitalization Rates Compared to Rituximab in MS

    Ocrelizumab Leads to Lower Hospitalization Rates Compared to Rituximab in MS

    Ocrelizumab (Ocrevus; Genentech) appears to have a more favorable safety profile in patients with multiple sclerosis (MS) compared to rituximab (Rituxan; Genentech and Biogen), according to a new analysis based on real-world data.1

    The findings…

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  • 120 pigs per car: oil lobby’s EU biofuels loophole could see…

    120 pigs per car: oil lobby’s EU biofuels loophole could see…

    Inserting a biofuels loophole in the EU 2035 cars law could see a huge spike in demand for biofuels from waste feedstocks like animal fats, used cooking oil and palm oil by-products, new T&E analysis finds. A car running on animal fats, for example, would require the equivalent of 120 pigs a year. This additional demand could lead to cars, planes and ships consuming two to nine times more advanced biofuels than can be sustainably sourced in the future.

    The EU is under pressure from the fuels and cars industries to allow new combustion engines running on biofuels to be sold after its 2035 deadline for zero-emission cars. This loophole, which is also supported by the Italian government, would see cars gobble up the very limited supplies of sustainable, advanced biofuels and make it more difficult to green hard-to-decarbonise sectors like aviation. Based on current European targets, planes and ships alone will require roughly double the amount of advanced biofuels than can be sustainably sourced in Europe – in the most optimistic scenario – in 2050.

    Lucien Mathieu, cars director at T&E, said: “The push for biofuels is absurd. Europeans can’t eat enough pork or fries to sustainably run even a fraction of Europe’s cars let alone its ships and planes. Why are the car and oil lobbies flogging non-solutions when we have a ready technology in electric cars? This is nothing but a delay tactic that will leave Europe uncompetitive in the global EV market.”

    Advanced biofuels such as waste-based fuels are not scalable. Europe already imports more than 80% of its used cooking oil from places like China and Malaysia. Animal fats are one of the most popular waste feedstocks. Already today, European cars use 1.3 million tonnes of animal fats per year – equivalent to 200 million slaughtered pigs. For every new car running on animal fats, around 120 pigs would be required a year, the analysis finds. Alternatively, a new car running on used cooking oil would need 25 kg of fries per day.

    A huge gap between the demand and the availability of sustainably sourced biofuels will also increase Europe’s dependency on imports. Currently, T&E estimates that 60% of Europe’s biofuels – including crop-based and advanced – are imported from third-countries. With the extra demand for cars created by a biofuels loophole, this could rise to 90% in 2050, the analysis finds.

    A greater dependency on biofuels imports would also increase the risk of fraud where virgin palm oil and other edible vegetable oils are passed off as waste oils. Previous investigations by T&E have shown alarming mismatches in waste biofuel imports into Europe, strongly suggesting fraud is occurring. For example, Europe imports three times more used cooking oil from Malaysia than can be collected in the country. In another investigation, T&E showed that Europe imports more palm oil mill effluent – a palm oil byproduct – than can be collected globally.

    Last week the German car lobby VDA joined with automotive supplier association CLEPA and 28 fuels companies and associations to tell the EU Commission that vehicles running on biofuels should be treated as zero emissions after 2035.[1] The European carmaker association ACEA has called for a “pragmatic implementation” of rules allowing new cars powered by carbon neutral fuels to be registered after 2035.[2]

    Notes to editors:

    [1] “Vehicles running exclusively on renewable fuels, must be recognised as zero-emission vehicles… Those fuels shall include renewable and/or synthetic fuels, such as biofuel, biogas, biomass fuel, renewable liquid and gaseous transport fuel of non-biological origin (RFNBO) or a recycled carbon fuel (RCF).”

    Joint letter by VDA, CLEPA and fuels companies and associations to the EU Commission:

    https://www.vda.de/dam/jcr:c2010722-0e33-43f3-b1d1-c6d17ab07835/2025_Joint%20Statement_ENG.pdf?mode=view

    [2] ACEA position paper, October 2025, page 8.

    ACEA-policy-paper-EU-regulatory-framework-for-the-decarbonisation-of-road-transport.pdf

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  • Severe asthma can be controlled by a monthly injection, trial finds | Asthma

    Severe asthma can be controlled by a monthly injection, trial finds | Asthma

    A monthly injection could allow people with severe asthma to stop taking daily steroid tablets, a clinical trial has found.

    More than 260 million people are thought to have asthma worldwide. While most can control their asthma with inhalers to…

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