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  • US FDA extends review of Ascendis Pharma’s therapy for children with dwarfism

    US FDA extends review of Ascendis Pharma’s therapy for children with dwarfism

    Nov 25 (Reuters) – The U.S. Food and Drug Administration on Tuesday extended its review of Ascendis Pharma’s (A71.F), opens new tab therapy for children with a rare genetic disorder that causes dwarfism, the company said.

    The health regulator extended its review by 3 months to February 28, 2026.

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    The FDA extended the deadline after Ascendis submitted additional information on November 5 regarding a required follow-up study, prompting a major change to the application, the company said.

    Ascendis had answered all remaining questions from the agency, including providing a revised plan for the post-approval study, and would continue to work closely with the FDA to finalize the requirements, CEO Jan Mikkelsen said.

    The rare disorder, called achondroplasia, is caused by a genetic mutation that affects a protein in the body called fibroblast growth factor receptor 3, or FGFR3, resulting in dwarfism.

    Ascendis’ therapy, TransCon CNP, targets a naturally occurring peptide called C-type natriuretic peptide (CNP), which has been shown to counteract the growth-inhibiting effects of the FGFR3 mutation and stimulate growth.

    Reporting by Sriparna Roy, Sahil Pandey and Sneha S K in Bengaluru; Editing by Leroy Leo

    Our Standards: The Thomson Reuters Trust Principles., opens new tab

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  • Arne Slot told ‘slap in the face’ comments actually ‘felt like a punch’ as Liverpool boss faces fan backlash for awful run of form

    Arne Slot told ‘slap in the face’ comments actually ‘felt like a punch’ as Liverpool boss faces fan backlash for awful run of form

    The reaction was much like @aeren__09, who said: “What about the 5 losses before that?” Which was a view @Bishop_Yayo agreed with, saying: “Oh dear lord…. The others defeats had no effect on yous? 😭😭😭😭.”

    And @dannwaneri added: “If it…

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  • Arne Slot told ‘slap in the face’ comments actually ‘felt like a punch’ as Liverpool boss faces fan backlash for awful run of form

    Arne Slot told ‘slap in the face’ comments actually ‘felt like a punch’ as Liverpool boss faces fan backlash for awful run of form

    The reaction was much like @aeren__09, who said: “What about the 5 losses before that?” Which was a view @Bishop_Yayo agreed with, saying: “Oh dear lord…. The others defeats had no effect on yous? 😭😭😭😭.”

    And @dannwaneri added: “If it…

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  • North Sea drilling restrictions to be relaxed in new Labour plan

    North Sea drilling restrictions to be relaxed in new Labour plan

    Plans to relax restrictions on new oil and gas drilling in the North Sea will be unveiled on Wednesday under the government’s North Sea Strategy.

    Chancellor Rachel Reeves will announce the publication of the strategy as part of her Budget speech, the BBC understands. The Department for Energy Security and Net Zero will release a document on it shortly after.

    The strategy is expected to confirm the government is relaxing its moratorium on new drilling for oil and gas in a form in which it can argue the new areas are extensions of existing infrastructure.

    This idea for allowing new drilling in a way that can be “tied back” to existing fields was first floated at the Labour conference in September.

    The results of the North Sea review will not directly reference the decision being considered by ministers over whether to give the go ahead to the controversial Rosebank field, which Ed Miliband was vocally opposed to while in opposition.

    That project is the subject of a separate and ongoing regulatory and judicial process. However, the wider relaxation in rules is widely thought to increase the chances Rosebank will ultimately be approved.

    Tiebacks have historically been used for small remote extensions to existing oil and gas fields which geologically stray into currently unlicenced areas of seabed.

    Rosebank is a much larger facility which requires its own production infrastructure.

    There has also been speculation that the windfall tax of 78% – due to expire in 2030 – might be phased out earlier.

    The oil and gas industry has been lobbying hard in recent months for changes to the windfall tax, or energy profits levy, which they say has been crippling the industry.

    Investment is at an all-time low with operators instead looking to spend their money in parts of the world with more favourable tax rates.

    Research from Robert Gordon University in Aberdeen estimates that about 1,000 jobs a month are currently being lost.

    It is understood the green light for “tie backs” would be viewed as a hollow gesture without at least some concessions on taxation.

    A kind of “cap and floor” mechanism would seem like the most likely move from government, which would kick in if oil prices returned to high levels like they did in the aftermath of the Russian invasion of Ukraine.

    The industry argues that subsequent falls in the price of crude oil demonstrate that the “windfall” has now ended and that taxation should reflect that change.

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  • Pixel Launcher gets vibrant Dynamic Color in Android 16 QPR2

    Pixel Launcher gets vibrant Dynamic Color in Android 16 QPR2

    Android 16 QPR2 is a sizable update that includes an updated color palette for the recently redesigned Pixel Launcher search bar.

    Google starts by updating the larger background container. When the system dark theme is…

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  • Aviation Capital Group Announces its First Airbus A220 Delivery to ITA Airways

    Aviation Capital Group Announces its First Airbus A220 Delivery to ITA Airways

    NEWPORT BEACH, Calif.–(BUSINESS WIRE)–Aviation Capital Group LLC (ACG), a premier global full-service aircraft asset manager, announced today the delivery of its first new Airbus A220-300 to ITA Airways, a new customer for ACG.

    This…

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  • News Releases | Boeing Newsroom

    News Releases | Boeing Newsroom

    – ViaSat-3 F2, second of three ultra-high-capacity satellites Boeing is building for global network operator Viasat, launched via United Launch Alliance’s Atlas V

    CAPE CANAVERAL SPACE FORCE STATION, Fla., Nov. 14, 2025 — Boeing [NYSE: BA] mission controllers confirmed the second ViaSat‑3 satellite, built on the company’s high‑power 702MP+ platform,…

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  • NASA telescope data hints at first direct detection of dark matter

    NASA telescope data hints at first direct detection of dark matter

    Dark matter has long been the universe’s most profound ghost, its existence confirmed only by the gravitational havoc it wreaks on visible galaxies. 

    Now, a team from the University of Tokyo suggests they may have gathered “direct…

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  • The BMW Z4 Final Edition. An exclusive take on the iconic roadster.

    The BMW Z4 Final Edition. An exclusive take on the iconic roadster.

    Sheer driving pleasure has always been baked into the BMW brand’s
    DNA. The BMW Z4 is a prime example: truly exhilarating roadster fun.
    Since the start of the first model generation in 2002, this open-top
    sports car has…

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  • In a First for Humanity, Scientists May Have Finally Seen Dark Matter – SciTechDaily

    1. In a First for Humanity, Scientists May Have Finally Seen Dark Matter  SciTechDaily
    2. Study claims to provide first direct evidence of dark matter  The Guardian
    3. A mysterious glow surrounding the Milky Way could be first evidence of dark matter  BBC…

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