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  • Study overturns assumptions about PTPN22 risk gene’s role in interferon production

    Study overturns assumptions about PTPN22 risk gene’s role in interferon production

    A new paper from the University of Kansas overturns the idea that a “risk gene” carried by millions of people worldwide influences production of Type 1 interferon, a workhorse of the immune system.

    Humans with the PTPN22 R620W…

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  • Inflation up to 3.8% as price pressures rise and hopes for interest rate cuts fall | Australian economy

    Inflation up to 3.8% as price pressures rise and hopes for interest rate cuts fall | Australian economy

    Inflation has climbed to 3.8% in the year to October, from 3.6% the month before, as Jim Chalmers flagged he could announce further energy bill subsidies for households in the upcoming midyear budget.

    Electricity prices were 37% higher in the year to October, which the Australian Bureau of Statistics said mostly reflected the end of state government power bill rebates.

    The ABS released its first “complete” monthly consumer price index, a milestone moment that will eventually see the more frequent inflation number supersede the quarterly figure.

    It confirmed an unwelcome upswing in price pressures that has crimped hopes for more Reserve Bank interest rate cuts, and even raised the potential the next move could be up.

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    Underlying inflation, which removes the impact of large, temporary price swings like in electricity prices, lifted from 3.2% in September to 3.3% in the year to October.

    With cost of living still the number one issue facing voters, Chalmers said before the release of the latest inflation numbers that the government would decide in “the next few weeks” whether to extend household energy bill rebates beyond the end of this year.

    The treasurer has perviously said there would be no major policy announcements in the midyear budget, due around 17 December, but in a Sky television interview opened the door to further electricity subsidies.

    With the Coalition using parliamentary question time to hammer the government on energy prices, Chalmers said “we’ve been very clear and very upfront for some time now – this electricity bill relief is really important”.

    “It is taking some of the edge off power prices for families and pensioners and people in our communities right around Australia.”

    He repeated his mantra that energy rebates “won’t be a permanent feature of the budget” but left the door open to extending the measures beyond December.

    “We’ll take a decision about that in the next few weeks.”

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    The March budget extended the commonwealth’s energy bill relief fund for six months, which gave another $150 to all households and about 1 million small businesses, split into two quarterly instalments.

    The opposition leader, Sussan Ley, repeatedly dodged questions in a Wednesday morning interview over whether the Coalition supported extending the power bill subsidies.

    More details soon …

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  • Long-term calorie restriction can slow cellular markers of brain aging

    Long-term calorie restriction can slow cellular markers of brain aging

    As the brain ages, cells in the central nervous system experience metabolic dysfunction and increased oxidative damage. These cellular issues impair the ability to maintain the myelin sheath (the protective covering around nerve…

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  • How immune signals activate brain circuits to drive sickness-induced social withdrawal

    How immune signals activate brain circuits to drive sickness-induced social withdrawal

    MIT researchers have discovered how an immune system molecule triggers neurons in a specific brain circuit to shut down social behavior in mice modeling infection.

    “I just can’t make it tonight. You have fun without me.” Across much…

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  • Unemployment rate rises to 7.1%

    Unemployment rate rises to 7.1%


    ISLAMABAD:

    The new Labour Force Survey has revealed that the unemployment…

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  • Binance accused of aiding terrorists in new lawsuit

    Binance accused of aiding terrorists in new lawsuit

    Binance and its founders, including billionaire Changpeng Zhao, are facing a lawsuit in the US accusing the company of helping send millions of dollars to US- designated terrorist organisations, including Hamas and Hezbollah.

    The legal action against the world’s largest cryptocurrency platform was brought by US victims of the 7 October, 2023, attacks in Israel or their families.

    It is poised to revive scrutiny of the firm’s practices just a few weeks after President Donald Trump pardoned Zhao, who had pleaded guilty in 2023 to charges related to money laundering.

    Binance declined to comment on the litigation but said it complied “fully with internationally recognised sanctions laws”.

    The lawsuit accuses the firm of knowingly facilitating the transfer of more than $1bn to and from accounts connected to organisations designated by the US as foreign terrorist groups and responsible for the 7 October attacks.

    Those payments included $50m sent after the 7 October attacks and at least two transactions sent from the US, according to the lawsuit, which was filed in federal court in North Dakota.

    Binance in November 2023 had pleaded guilty and agreed to pay more than $4bn in penalties to resolve charges of money laundering and sanctions violations brought by the US government.

    At the time, it pledged to improve its anti-money laundering and sanctions compliance programmes as part of that agreement.

    But even after the settlement, according to the lawsuit, the company maintained a policy to only screen funds for suspicious activity when customers tried to transfer money off the platform.

    “By deliberately failing to monitor inbound funds, Binance ensured that terrorists and other criminals could deposit and shuffle enormous sums on the exchange with impunity,” , the complaint says.

    It alleges that the company “intentionally structured itself as a refuge for illicit activity”.

    “To this day, there is no indication that Binance has meaningfully altered its core business model,” the complaint says.

    The families are seeking financial damages from the company to be determined in a jury trial.

    In a statement, Binance said it had improved its compliance systems and that “illicit flows” represented a tiny fraction of the money traded on its platform.

    “We remain steadfast in our commitment to working with regulators, law enforcement, and our users to protect the integrity of the global digital-asset ecosystem,” a spokesperson said in a statement.

    The lawsuit follows controversy over Trump’s decision last month to pardon Zhao, also known as “CZ”, who had admitted he failed to maintain an effective anti-money laundering programme at Binance.

    Trump, whose family has business ties to Zhao, subsequently claimed he had ” no idea” who Mr Zhao was, while acknowledging his sons’ involvement in the crypto industry.

    In a letter to administration officials last month, top Democrats said they were concerned the pardon would encourage criminal activity, alleging that it signalled to “cryptocurrency executives and other white-collar criminals that they can commit crimes with impunity, so long as they enrich President Trump enough”.

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  • Prefrontal cortex modulates visual and motor regions based on internal feelings

    Prefrontal cortex modulates visual and motor regions based on internal feelings

    Vision shapes behavior and, a new study by MIT neuroscientists finds, behavior and internal states shape vision. The research, published Nov. 25 in Neuron, finds in mice that via specific circuits, the brain’s executive control…

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  • 50 Cent’s Sean ‘Diddy’ Combs documentary gets a Netflix release date

    50 Cent’s Sean ‘Diddy’ Combs documentary gets a Netflix release date

    Curtis “50 Cent” Jackson’s documentary about Sean Combs finally has a release date.

    Netflix announced Tuesday that it would release “Sean Combs: The Reckoning,” a four-part docuseries about the disgraced mogul directed by Alexandria…

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  • Looking at the Narrative for Varonis After Analyst Split on SaaS Transition and Growth Outlook

    Looking at the Narrative for Varonis After Analyst Split on SaaS Transition and Growth Outlook

    Varonis Systems’ fair value estimate remains unchanged at approximately $52.63 per share. This reflects a stable outlook despite recent market shifts. Analyst sentiment is mixed, with positive momentum from the company’s SaaS transition balanced against concerns over legacy business headwinds. Stay tuned to discover how you can keep up with the evolving analyst perspectives that shape the stock’s future story.

    Analyst Price Targets don’t always capture the full story. Head over to our Company Report to find new ways to value Varonis Systems.

    Analyst commentary on Varonis Systems remains divided, with several firms recently updating their outlooks and price targets in response to both firm-specific and broader market developments. Here is a balanced look at the latest perspectives:

    🐂 Bullish Takeaways

    • Several firms, including JPMorgan and UBS, raised their price targets substantially. JPMorgan increased its target to $79 from $70, while UBS moved to $70 from $65. Both moves reflect optimism around Varonis’ ongoing SaaS transition and perceived growth acceleration opportunities.

    • Truist, Cantor Fitzgerald, and Morgan Stanley also cited strong execution and steady progress in transitioning to a SaaS model as reasons to increase targets, focusing on improved key performance indicators, growth momentum, and positioning for future operating improvements.

    • Cantor Fitzgerald and Morgan Stanley highlighted Varonis’ ability to strengthen its competitive position, as well as anticipated growth in data security posture management as a core driver for AI preparedness.

    • Analysts pointed to new product lines, including GenAI and Managed Data Detection and Response offerings, as potential upside catalysts for revenue and competitiveness.

    • Despite the overall positive outlook, some bullish analysts, such as DA Davidson, issued a note of caution regarding valuation and suggested that much of the upside may already be reflected in the share price.

    🐻 Bearish Takeaways

    • Bearish and more neutral voices have grown louder following recent results. Both Truist and Susquehanna lowered their price targets to $50, citing short-term concerns stemming from weaker than anticipated renewal rates, particularly in the On-Prem segment, which has been declining as Varonis migrates customers to its SaaS offerings.

    • Piper Sandler took a more cautious stance, reducing its target to $45 and highlighting a miss on quarterly annual recurring revenue, lowered full-year projections, and a company-wide resource realignment including a 5 percent reduction in force. Piper Sandler also noted uncertainty following the announced end-of-life for Varonis’ on-prem solutions.

    • Persistent reservations among less bullish analysts revolve around near-term execution risks, the impact of declining federal and legacy business renewals, and a conservative outlook for the upcoming quarter.

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  • Moss Can Survive Long-Term Exposure to Elements of Space, New Experiments Show

    Moss Can Survive Long-Term Exposure to Elements of Space, New Experiments Show

    A team of researchers from Japan has tested protenemata (juvenile moss), brood cells (specialized stem cells that emerge under stress conditions) and sporophytes (encapsulated spores) of the model moss species Physcomitrium patens under…

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