Published on: Nov 25, 2025 03:00 pm IST
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WHO SEARO Reviews Pandemic Influenza Preparedness (PIP) Partnership Contribution (PC) Investments for 2025
Influenza remains a significant and evolving global health threat, requiring sustained surveillance, timely access to countermeasures, and robust national preparedness capacities. In line with the PIP Framework and WHO’s Global Influenza…Continue Reading
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Australian Sen. Pauline Hanson suspended from Parliament for wearing burqa in protest
MEBOURNE, Australia — An Australian senator who is campaigning for a national burqa ban was barred Tuesday from Parliament for the rest of the year for wearing the Muslim garment in the chamber.
Pauline Hanson, the 71-year-old leader of the…
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Samsung Is Reportedly Favoring Perplexity Over Gemini to Upgrade Bixby – PCMag
- Samsung Is Reportedly Favoring Perplexity Over Gemini to Upgrade Bixby PCMag
- Samsung Copies Apple’s Playbook: Perplexity AI To Power Bixby Wccftech
- Samsung may revamp Bixby with Perplexity AI in Galaxy S26 for smarter, deeper answers: Here’s…
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policy progress, challenges, and pathways forward – CEPS
Gender equality and gender mainstreaming have been established as central priorities within the European Union’s current Framework Programme for Research and Innovation (R&I), Horizon Europe (2021–27). The European Commission has demonstrated a strong commitment to promoting gender equality through measures such as mandatory Gender Equality Plans (GEPs) and the systemic integration of the gender perspective in research. However, despite progress, available data indicate that advancements remain slow, underscoring the need for more robust action by the EU to achieve meaningful equality in this field.
Drawing on existing literature and data, this paper introduces a new theoretical framework for analysing the integration of gender equality and gender mainstreaming in Horizon Europe across three interrelated dimensions: structural, epistemic and substantive. It conceptualises gender equality in R&I as a circle, where progress in one dimension can mutually reinforce advancement in the others. The paper further identifies emerging themes and priority areas for the next Framework Programme, addressing persistent challenges in gender equality, and proposes seven targeted policy actions.
Implementing these measures would enhance the EU’s capacity to mainstream gender in research, strengthen its leadership in promoting gender equality, and its position as a global example for gender-responsive R&I.
To read all publications in the ‘EU R&I and Health Policy’ series, please click here.
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Zach Bryan, Michael Bublé and Deftones announce summer 2026 shows – The Irish Times
Zach Bryan, Michael Bublé and Deftones have each announced shows for summer 2026 in Ireland.
American country singer Zach Bryan will perform four dates in the country; in Cork on June 20th and 21st, and in Belfast on June 23rd and 24th.
Tickets…
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A case report of a fatal case of advanced AIDS combined with monkeypox
Introduction
Mpox is a viral disease caused by the mpox virus, a member of the orthopoxvirus genus. It was discovered in humans in 1970 in the Democratic Republic of Congo (formerly Zaire), and sporadic outbreaks of the virus have been recorded…
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Five key moments from Ella Lloyd’s F1 Academy season
In a difficult Qualifying session around the tricky streets of Las Vegas, Ella could only muster 10th position on the starting grid, but she surged into contention in Race 1 in wet conditions, latching onto the rear of the lead train early on….
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Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes | BMC Biology
Yamanaka S. Pluripotent stem cell-based cell therapy-promise and challenges. Cell Stem Cell. 2020;27(4):523–31.
Hoang DM, Pham PT, Bach TQ, Ngo ATL, Nguyen QT, Phan TTK, et al. Stem cell-based therapy for human diseases. Signal Transduct Target Ther. 2022;7(1):272.
Galipeau J, Sensébé L. Mesenchymal stromal cells: clinical challenges and therapeutic opportunities. Cell Stem Cell. 2018;22(6):824–33.
Kabat M, Bobkov I, Kumar S, Grumet M. Trends in mesenchymal stem cell clinical trials 2004-2018: is efficacy optimal in a narrow dose range? Stem Cells Transl Med. 2020;9(1):17–27. https://doi.org/10.1002/sctm.19-0202.
Yin JQ, Zhu J, Ankrum JA. Manufacturing of primed mesenchymal stromal cells for therapy. Nat Biomed Eng. 2019;3(2):90–104.
Taherian Fard A, Leeson HC, Aguado J, Pietrogrande G, Power D, Gómez-Inclán C, et al. Deconstructing heterogeneity of replicative senescence in human mesenchymal stem cells at single cell resolution. Geroscience. 2024;46(1):999–1015. https://doi.org/10.1007/s11357-023-00829-y.
Miclau K, Hambright WS, Huard J, Stoddart MJ, Bahney CS. Cellular expansion of MSCs: shifting the regenerative potential. Aging Cell. 2023;22(1):e13759. https://doi.org/10.1111/acel.13759.
Huang Y, Li Q, Zhang K, Hu M, Wang Y, Du L, et al. Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity. Cell Death Dis. 2019;10(5):368.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. Hallmarks of aging: an expanding universe. Cell. 2023;186(2):243–78.
Hu M, Xing L, Zhang L, Liu F, Wang S, Xie Y, et al. NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation. Aging Cell. 2022;21(2):e13551. https://doi.org/10.1111/acel.13551.
Weng Z, Wang Y, Ouchi T, Liu H, Qiao X, Wu C, et al. Mesenchymal stem/stromal cell senescence: hallmarks, mechanisms, and combating strategies. Stem Cells Transl Med. 2022;11(4):356–71.
Weber L, Lee BS, Imboden S, Hsieh CJ, Lin NYC. Phenotyping senescent mesenchymal stromal cells using AI image translation. Curr Res Biotechnol. 2023;5:100120. https://doi.org/10.1016/j.crbiot.2023.100120.
Li X, Luo X, He Y, Xu K, Ding Y, Gao P, et al. Micronano titanium accelerates mesenchymal stem cells aging through the activation of senescence-associated secretory phenotype. ACS Nano. 2023;17(22):22885–900.
Brunet A, Goodell MA, Rando TA. Ageing and rejuvenation of tissue stem cells and their niches. Nat Rev Mol Cell Biol. 2023;24:45–62.
Yoshioka N, Gros E, Li HR, Kumar S, Deacon DC, Maron C, et al. Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013;13(2):246–54.
Jiao H, Walczak BE, Lee MS, Lemieux ME, Li WJ. GATA6 regulates aging of human mesenchymal stem/stromal cells. Stem Cells. 2021;39(1):62–77.
Xu Q, Fu Q, Li Z, Liu H, Wang Y, Lin X, et al. The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice. Nat Metab. 2021;3(12):1706–26.
Zhang C, Han X, Liu J, Chen L, Lei Y, Chen K, et al. Single-cell transcriptomic analysis reveals the cellular heterogeneity of mesenchymal stem cells. Genomics Proteomics Bioinformatics. 2022;20(1):70–86.
Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature. 2018;562(7728):578–82.
Srinivasan A, Sathiyanathan P, Yin L, Liu TM, Lam A, Ravikumar M, et al. Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy. 2022;24(5):456–72.
Ross EA, Turner LA, Donnelly H, Saeed A, Tsimbouri MP, Burgess KV, et al. Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells. Nat Commun. 2023;14(1):753.
Yuan H, Xu Y, Luo Y, Zhang JR, Zhu XX, Xiao JH. Ganoderic acid D prevents oxidative stress-induced senescence by targeting 14-3-3ε to activate CaM/CaMKII/NRF2 signaling pathway in mesenchymal stem cells. Aging Cell. 2022;21(9):e13686. https://doi.org/10.1111/acel.13686.
Xu Y, Yuan H, Luo Y, Zhao YJ, Xiao JH. Ganoderic acid D protects human amniotic mesenchymal stem cells against oxidative stress-induced senescence through the PERK/NRF2 signaling pathway. Oxid Med Cell Longev. 2020;2020:8291413. https://doi.org/10.1155/2020/8291413.
Wong PF, Dharmani M, Ramasamy TS. Senotherapeutics for mesenchymal stem cell senescence and rejuvenation. Drug Discov Today. 2023;28(1):103424. https://doi.org/10.1016/j.drudis.2022.103424.
Chaib S, Tchkonia T, Kirkland JL. Cellular senescence and senolytics: the path to the clinic. Nat Med. 2022;28:1556–68.
Ovadya Y, Landsberger T, Leins H, Vadai E, Gal H, Biran A, et al. Impaired immune surveillance accelerates accumulation of senescent cells and aging. Nat Commun. 2018;9(1):5435.
Chelyapov N, Nguyen TT, Gonzalez R. Autologous NK cells propagated and activated ex vivo decrease senescence markers in human PBMCs. Biochem Biophys Rep. 2022;32:101380. https://doi.org/10.1016/j.bbrep.2022.101380.
Tang X, Deng B, Zang A, He X, Zhou Y, Wang D, et al. Characterization of age-related immune features after autologous NK cell infusion: protocol for an open-label and randomized controlled trial. Front Immunol. 2022;13:940577. https://doi.org/10.3389/fimmu.2022.940577.
Bayik D, Lathia JD. Cancer stem cell-immune cell crosstalk in tumour progression. Nat Rev Cancer. 2021;21(8):526–36.
Bobyleva P, Gornostaeva A, Andreeva E, Ezdakova M, Gogiya B, Buravkova L. Reciprocal modulation of cell functions upon direct interaction of adipose mesenchymal stromal and activated immune cells. Cell Biochem Funct. 2019;37(4):228–38.
Valencic E, Loganes C, Cesana S, Piscianz E, Gaipa G, Biagi E, et al. Inhibition of mesenchymal stromal cells by pre-activated lymphocytes and their culture media. Stem Cell Res Ther. 2014;5(1):3.
Bobyleva PI, Andreeva ER, Gornostaeva AN, Buravkova LB. Tissue-related hypoxia attenuates proinflammatory effects of allogeneic PBMCs on adipose-derived stromal cells in vitro. Stem Cells Int. 2016;2016(1):4726267. https://doi.org/10.1155/2016/4726267.
Al-Azab M, Safi M, Idiiatullina E, Al-Shaebi F, Zaky MY. Aging of mesenchymal stem cell: machinery, markers, and strategies of fighting. Cell Mol Biol Lett. 2022;27(1):69.
Olsen Saraiva Camara N, Lepique AP, Basso AS. Lymphocyte differentiation and effector functions. Clin Dev Immunol. 2012;2012:510603.
Van der Meide PH, Schellekens H. Cytokines and the immune response. Biotherapy. 1996;8(3–4):243–9. https://doi.org/10.1007/BF01877210.
Green DR, Kroemer G. Cytoplasmic functions of the tumour suppressor p53. Nature. 2009;458:1127–30.
Rodríguez JA. Interplay between nuclear transport and ubiquitin/SUMO modifications in the regulation of cancer-related proteins. Semin Cancer Biol. 2014;27:11–9.
Castrogiovanni C, Waterschoot B, De Backer O, Dumont P. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018;25(1):190–203.
Chang HM, Yeh ETH. SUMO: from bench to bedside. Physiol Rev. 2020;100(4):1599–619.
Burczynski ME, Peterson RL, Twine NC, Zuberek KA, Brodeur BJ, Casciotti L, et al. Molecular classification of Crohn’s disease and ulcerative colitis patients using transcriptional profiles in peripheral blood mononuclear cells. J Mol Diagn. 2006;8(1):51–61.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109(4):E177-86.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, et al. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Dev Cell. 2014;31(6):722–33.
Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, et al. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science. 2022;378(6616):192–201.
Prata LGPL, Ovsyannikova IG, Tchkonia T, Kirkland JL. Senescent cell clearance by the immune system: emerging therapeutic opportunities. Semin Immunol. 2018;40:101275. https://doi.org/10.1016/j.smim.2019.04.003.
Carvalho AÉS, Sousa MRR, Alencar-Silva T, Carvalho JL, Saldanha-Araujo F. Mesenchymal stem cells immunomodulation: the road to IFN-γ licensing and the path ahead. Cytokine Growth Factor Rev. 2019;47:32–42.
Mabuchi Y, Okawara C, Méndez-Ferrer S, Akazawa C. Cellular heterogeneity of mesenchymal stem/stromal cells in the bone marrow. Front Cell Dev Biol. 2021;9:689366. https://doi.org/10.3389/fcell.2021.689366.
Marin I, Boix O, Garcia-Garijo A, Sirois I, Caballe A, Zarzuela E, et al. Cellular senescence is immunogenic and promotes antitumor immunity. Cancer Discov. 2023;13(2):410–31.
Baar MP, Brandt RMC, Putavet DA, Klein JDD, Derks KWJ, Bourgeois BRM, et al. Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging. Cell. 2017;169(1):132-147.e16.
Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, et al. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nat Commun. 2019;10(1):2387.
Wang TW, Johmura Y, Suzuki N, Omori S, Migita T, Yamaguchi K, et al. Blocking PD-L1-PD-1 improves senescence surveillance and ageing phenotypes. Nature. 2022;611(7935):358–64.
Onder TT, Kara N, Cherry A, Sinha AU, Zhu N, Bernt KM, et al. Chromatin-modifying enzymes as modulators of reprogramming. Nature. 2012;483(7391):598–602.
Naik S, Larsen SB, Gomez NC, Alaverdyan K, Sendoel A, Yuan S, et al. Inflammatory memory sensitizes skin epithelial stem cells to tissue damage. Nature. 2017;550(7677):475–80.
Gonzales KAU, Polak L, Matos I, Tierney MT, Gola A, Wong E, et al. Stem cells expand potency and alter tissue fitness by accumulating diverse epigenetic memories. Science. 2021;374(6571):eabh2444.
Lanna A, Vaz B, D’Ambra C, Valvo S, Vuotto C, Chiurchiù V, et al. An intercellular transfer of telomeres rescues T cells from senescence and promotes long-term immunological memory. Nat Cell Biol. 2022;24(10):1461–74.
Mahmoudi S, Mancini E, Xu L, Moore A, Jahanbani F, Hebestreit K, et al. Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing. Nature. 2019;574(7779):553–8.
Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Proc Natl Acad Sci U S A. 2016;113:E5024–33.
Galanos P, Vougas K, Walter D, Polyzos A, Maya-Mendoza A, Haagensen EJ, et al. Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing. Nat Cell Biol. 2016;18(7):777–89.
Lapasset L, Milhavet O, Prieur A, Besnard E, Babled A, Aït-Hamou N, et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011;25(21):2248–53.
Li W, Liu Q, Shi J, Xu X, Xu J. The role of TNF-α in the fate regulation and functional reprogramming of mesenchymal stem cells in an inflammatory microenvironment. Front Immunol. 2023;14:1074863.
Magne B, Dedier M, Nivet M, Coulomb B, Banzet S, Lataillade JJ, et al. IL-1β-primed mesenchymal stromal cells improve epidermal substitute engraftment and wound healing via matrix metalloproteinases and transforming growth factor-β1. J Invest Dermatol. 2020;140(3):688-698.e21.
Renner L, von Soosten D, Sipka A, Döll S, Beineke A, Schuberth HJ, et al. Effect of conjugated linoleic acid on proliferation and cytokine expression of bovine peripheral blood mononuclear cells and splenocytes ex vivo. Arch Anim Nutr. 2012;66(2):73–85.
Dagur PK, McCoy JP Jr. Collection, storage, and preparation of human blood cells. Curr Protoc Cytom. 2015;73:5.1.1-5.1.16.
Fu YP, Yuan H, Xu Y, Liu RM, Luo Y, Xiao JH. Protective effects of Ligularia fischeri root extracts against ulcerative colitis in mice through activation of Bcl-2/Bax signalings. Phytomedicine. 2022;99:154006.
Wang AT, Zhang QF, Wang NX, Yu CY, Liu RM, Luo Y, et al. Cocktail of hyaluronic acid and human amniotic mesenchymal cells effectively repairs cartilage injuries in sodium iodoacetate-induced osteoarthritis rats. Front Bioeng Biotechnol. 2020;8:87.
Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. [RNA-Seq]. NCBI, GEO. 2025. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307002.
Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. [RNA-Seq]. NCBI, GEO. 2025. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307003.
Luo Y, Zhu XX, Le QR, Chen WT, Xu Y, Chen XM, Yuan H, Yang X, Xu JW, Zhong JJ, Xiao JH. Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes-a dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system. ProteomeXchange. 2025. Accession: PXD066147, https://proteomecentral.proteomexchange.org/cgi/GetDataset?ID=PXD066147.
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Yojana Sharma
Proposed cuts to the NASA budget, which threaten US university-based space research programmes as well as joint space missions, have left international scientific…Continue Reading
