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  • De Minaur says he can beat Sinner, if he can execute the plan – ATP Tour

    1. De Minaur says he can beat Sinner, if he can execute the plan  ATP Tour
    2. Sinner dominates De Minaur to reach ATP Finals title match  Dawn
    3. Tennis, ATP Finals 2025: Jannik Sinner into third-straight championships match  Olympics.com
    4. Sinner equals…

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  • Review Highlights IGHV Testing Complexities in CLL

    Review Highlights IGHV Testing Complexities in CLL

    Immunoglobulin heavy chain variable (IGHV) testing has become an important prognostic and therapeutic factor in chronic lymphocytic leukemia (CLL), but advances in technologies such as next-generation sequencing (NGS) have amplified both the importance and the complexity of IGHV analysis, according to a new review.

    In the review, which was published in the International Journal of Laboratory Hematology, corresponding author Tanya L. Gillan, PhD, of Canada’s Dalhousie University, and colleagues outlined how the latest technological and methodological advances have shaped emerging strategies in diagnosing and treating CLL.1

    The authors noted that IGHV status has long been linked with patient outcomes. Patients with mutated IGHV have repeatedly been found to have substantially longer overall survival (OS) than those with unmutated IGHV, they explained. Furthermore, IGHV status has been shown to have the second-greatest impact on 5-year survival of any biomarker, second only to TP53 abnormalities.2

    Patients are considered to have unmutated IGHV if they have at least 98% homology to the germline sequence. Cases with homology below 98% or which are borderline are generally deemed to be mutated, and those patients have a more favorable prognosis, Gillan and colleagues said. They said that IGHV mutational status does not evolve over time, so it only requires testing at diagnosis or before initiating treatment.

    IGHV status has also been linked with time to treatment and treatment response. One study found patients with unmutated IGHV had a median progression-free survival (PFS) of 14.6 years after 19 years of follow-up, compared to 4.2 years among patients with unmutated IGHV.3

    Gillan and colleagues next discussed the guidelines published by the European Research Initiative on CLL (ERIC) and the ways they have evolved over time to answer newly emerging questions.1 First published in 2007, the most recent updates of the guidelines were published in 2022 and 2024. One focus on the 2022 update, they said, is the impact of IGHV mutation status and B-cell receptor immunoglobulin stereotypy on treatment response, the authors said. Another point of emphasis is the growing potential of NGS in immunogenetic analysis.

    Gillan and colleagues said Sanger sequencing had long been considered the “gold standard” for IGHV testing, but they said its adoption was limited by its labor intensiveness, technical complexity, limited scalability, and lack of insight into subclonal architecture and intraclonal diversity. More recently, NGS has been found to match the performance of Sanger sequencing, the authors said, without the same drawbacks. Yet, they said current amplicon-based methods of NGS are limited by amplification bias. They said targeted capture NGS can avoid such biases. The investigators discussed the state of the art of IGHV analysis at length, adding that NGS analysis has opened up new insights and new opportunities to refine prognostication.

    Gillan and colleagues said one benefit of NGS is that it allows for the combination of multiple assays in a single run, allowing for assessment of multiple clinically relevant mutations—not just IGHV mutations—at once. However, they said the technical advancements will also further the need for additional standardization.

    Moving forward, they said a number of issues need to be resolved, including the limited concordance between NGS and flow cytometry methodologies for detecting subclonal B-cell populations. They said the clinical significance of IGHV clonotypes remains unclear. Other questions remain unanswered as well, they said.

    The authors said NGS testing has allowed for new insights into the biology of IGHV and how to interpret IGHV mutations.

    “The clinical significance of the various IGHV scenarios—including multiple clones, unproductive or absent clones, stereotyped subsets, subclones, and major or minor stereotyped subsets—as well as the impact of novel therapies on IGHV [somatic hypermutation], which may mitigate the poor prognosis associated with certain IGHV clones, will continue to evolve as research in this field progresses,” they concluded.

    References

    1. Wood RK, Elsharawi I, Goudie M, Bruyère H, Rahmani M, Gillan TL. The ABCs of IGHV testing in chronic lymphocytic leukaemia: current recommendations, ongoing challenges, and future directions. Int J Lab Hematol. Published online October 28, 2025. doi:10.1111/ijlh.70010
    2. Hallek M, Cheson BD, Catovsky D, et al. iwCLL guidelines for diagnosis, indications for treatment, response assessment, and supportive management of CLL. Blood. 2018;131(25):2745-2760. doi:10.1182/blood-2017-09-806398
    3. Thompson PA, Bazinet A, Wierda WG, et al. Sustained remissions in CLL after frontline FCR treatment with very-long-term follow-up. Blood. 2023;142(21):1784-1788. doi:10.1182/blood.2023020158

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  • A Fresh Look at Intuit (INTU) Valuation After New AI Launches and Cherry Bekaert Partnership

    A Fresh Look at Intuit (INTU) Valuation After New AI Launches and Cherry Bekaert Partnership

    Intuit (INTU) is in the spotlight following a series of announcements on new AI capabilities across its core products. Expanded automation and intelligent insights now power QuickBooks, TurboTax, and Credit Karma.

    See our latest analysis for Intuit.

    Intuit’s flurry of AI-powered releases and a headline partnership with Cherry Bekaert have certainly kept the spotlight on its growth story. Even so, the share price hasn’t quite followed suit lately, with momentum cooling after early-year gains. Intuit’s 1-year total shareholder return sits at -3.1%, despite a strong 3-year figure of nearly 78%.

    If you’re keen to spot emerging opportunities beyond just major headlines, this is a great moment to broaden your perspective with fast growing stocks with high insider ownership

    With Intuit’s steady stream of innovation and analyst optimism, the key question emerges: does the current share price reflect all this future growth, or could investors be looking at a compelling entry point?

    Intuit’s last close comes in well below the most widely followed narrative’s fair value, hinting at unpriced growth that could surprise the market. Let’s look at the most important driver powering this perspective.

    The accelerating adoption of Intuit’s AI-driven all-in-one platform, including virtual teams of AI agents and human experts, positions the company to consolidate customers’ tech stacks, drive automation of workflows, and unlock substantial ROI for customers. This supports higher average revenue per customer (ARPC) and net margin expansion over time.

    Read the complete narrative.

    What’s behind this bullish outlook? Only the full narrative reveals the mix of game-changing digital adoption, margin leaps, and bold revenue bets that back up today’s optimistic price target. Don’t miss the details—the real drivers could shift the market’s view.

    Result: Fair Value of $807.12 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, ongoing challenges in Mailchimp recovery and softer international growth could quickly change the outlook if improvements stall or if markets weaken further.

    Find out about the key risks to this Intuit narrative.

    Switching gears, some investors look at the price-to-earnings ratio for signals. At 47.7x, Intuit’s valuation stands well above both the industry average (32.7x) and its own fair ratio of 43.2x. This gap suggests limited margin of safety, which could signal extra risk or justify the price if growth materializes.

    See what the numbers say about this price — find out in our valuation breakdown.

    NasdaqGS:INTU PE Ratio as at Nov 2025

    If you see things differently or want a clearer view, dig into the numbers yourself and shape your own perspective in just a few minutes, then Do it your way

    A good starting point is our analysis highlighting 4 key rewards investors are optimistic about regarding Intuit.

    Take your investing to the next level by leveraging expert-curated stock ideas. Uncover your next big winner today before the market catches on and leaves you behind.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include INTU.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • England 33-19 New Zealand: Hosts come from behind to claim stunning win

    England 33-19 New Zealand: Hosts come from behind to claim stunning win

    England had hoped that they would accelerate in the second half with a bench loaded with six British and Irish Lions. Instead, the nitro boost they needed came from those already on the pitch – and some Kiwi indiscipline.

    New Zealand hooker…

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  • As it happened: England complete historic win over New Zealand

    As it happened: England complete historic win over New Zealand

    England have arguably their best chance in several years to beat New Zealand for the first time since…

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  • Sofia Coppola & Kirsten Dunst “Talking About” Reuniting For New Film

    Sofia Coppola & Kirsten Dunst “Talking About” Reuniting For New Film

    After marking 25 years of their professional relationship last year, Sofia Coppola and Kirsten Dunst are about due for another collaboration.

    The Oscar-winning writer and director revealed that she and the Virgin Suicides (1999)…

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  • Wee Joo Chng: New Lancet Series on T-Cell and NK-Cell Lymphomas

    Wee Joo Chng: New Lancet Series on T-Cell and NK-Cell Lymphomas

    Wee Joo Chng, Vice President of Biomedical Science Research at the National University of Singapore and Group Director of Research Office at the National University Health System of Singapore, shared a post on 

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  • Atezolizumab/Vaccine Combo May Show Long-Term Survival in ES-SCLC

    Atezolizumab/Vaccine Combo May Show Long-Term Survival in ES-SCLC

    Combining dendritic cell (DC) vaccination with atezolizumab (Tecentriq) produced long-term survival in a small cohort of patients with extensive-stage small cell lung cancer (ES-SCLC), according to findings from a phase 1b/2 trial (NCT04487756)…

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  • US Patient Sick With Bird Flu Virus That Has “Pandemic Potential”: Report

    US Patient Sick With Bird Flu Virus That Has “Pandemic Potential”: Report

    A resident of Washington state has been admitted to the hospital with an H5N5 bird flu infection, according to state health…

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  • Black Friday deals include this Switch 2-compatible microSD Express card for a record-low price

    Black Friday deals include this Switch 2-compatible microSD Express card for a record-low price

    The SanDisk 256GB microSD Express Card for the Switch 2 is down to $60 via Amazon, which is a record-low price. This model is also available in storage sizes of 128GB and 512GB, but neither version is on sale.

    This particular model easily made our…

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