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  • Mortality and reproducibility of calcium measurements in patients with hypercalcemia reporting to the emergency department of a tertiary German hospital | International Journal of Emergency Medicine

    Mortality and reproducibility of calcium measurements in patients with hypercalcemia reporting to the emergency department of a tertiary German hospital | International Journal of Emergency Medicine

    Study design / ethical approval

    This study was a single-center retrospective cohort study. The study was approved by the local ethics committee (24-1193-retro) and registered on clincialtrials.gov (NCT06467877).

    Setting

    The study was conducted in…

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  • India inaugurates new military airbase close to China border

    India inaugurates new military airbase close to China border

    Air Chief Marshal AP Singh lands C-130J at Ladakh’s 13,000-ft Mudh-Nyoma airbase near China border

    Video grab shows C-130 plane near Mudh-Nyoma air force base. PHOTO: REUTERS

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  • Test Match Special Podcast – Wickets for Stokes, but injury worries for Wood

    Test Match Special Podcast – Wickets for Stokes, but injury worries for Wood

    Available for over a year

    Chief Cricket reporter Stephan Shemilt reports from Lilac Hill on a mixed opening day of England’s Ashes tour. Ben Stokes picked up four wickets in his first competitive bowl since July, but there was an injury concern…

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  • Auditors warn of funding risks to ITER fusion project

    Fusion for Energy (F4E), the organisation responsible for the EU’s €5.61 billion contribution to the International Thermonuclear Experimental Reactor (ITER) project in 2021-27, has been heavily criticised by auditors for failing to manage increased risks arising from changes to ITER’s scope and milestones made in 2024. These included postponing the end of the assembly phase from 2025 to 2035 and the end of the whole project from 2042 to 2059.

    While auditors have long sounded the alarm about rising costs at F4E, they now say that the organisation has failed to track these new legal, technical and financial risks, which could jeopardise the EU’s funding contribution.

    “F4E’s risk identification process mainly focuses on risks to the project’s operational implementation,” the European Court of Auditors (ECA) says in its latest report. “It does not address horizontal risks – such as the need to restructure the JU [Joint Undertaking] and reallocate human resources to adjust to the 2024 baselines, the disproportionate use of external service providers, topics of resource planning and management, and non-compliance with the EU Staff Regulations or the JU’s ethical framework – in a similar manner.”

    Added to inflation and supply chain pressures, the new baselines for ITER are estimated to cost an additional €4.2 billion in the contributions from the EU, which covers some 45% of the construction costs through its nuclear programme Euratom, and other partners funding F4E’s operational budget.

    “There is a financial risk that the significantly higher F4E contributions may not be sustainably financed by Euratom in the future,” the ECA says. In other words, the Euratom budget will not go up enough to cover the growing cost of the ITER project.

    In a written reply to the audit, F4E acknowledges these additional risks, which it is currently trying to “adequately show” in its risk register. It also points out that the revised plan for ITER presents opportunities.

    “In particular, the use of tungsten in the first wall instead of beryllium, and the redesign of hot cell facilities simplify safety demonstration and long-term operability, while reducing certain important cost drivers,” it says.

    Accounting weaknesses

    The criticism of F4E appears in the ECA’s annual assessment of EU Joint Undertakings, public partnerships set up by the European Commission to achieve strategic research and innovation goals. Financed by EU programmes, they cover areas ranging from global health to clean hydrogen to the circular bioeconomy. 

    Eleven JUs were set up in 2021, with €10 billion in Horizon Europe funding to be matched by private contributions in cash or in kind, for example through the use of data and laboratories.

    The ECA approved their 2024 accounts, but reiterated concerns about accounting and funding shortcomings. 

    “As in previous years, our audit revealed errors that showed weaknesses in the JUs’ management and control systems in respect of the legality and regularity of operational expenditure,” the ECA says in its report. “These errors mainly related to incorrect declarations of staff costs in grant transactions by the JUs’ beneficiaries.”

    Based on a random selection of grant payment and clearing transactions made by JUs under Horizon 2020, Horizon Europe and Digital Europe, the ECA cited errors in the calculation of hourly or daily rates, the reporting of the staff costs of SMEs, and the declaration of subcontracting costs, in part due to the complexity of cost declarations for beneficiaries.

    The auditors previously recommended that the JUs implement a risk-based framework to reinforce controls of the risky beneficiaries and projects. At the end of 2024, only four JUs had finalised such a framework for Horizon Europe grant payments.


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    The ECA also found shortcomings in budget planning for administrative spending, which mostly consists of salaries and routine payments. Two of the Joint Undertakings, the Clean Hydrogen Partnership and the Global Health European and Developing Countries Clinical Trials 3 Partnership (EDCTP3), blamed delays in recruitment procedures, refurbishment contracts and invoice submissions.

    The auditors however pointed out that low implementation rates had already been reported in the past and resulted in the accumulation of unused administrative payment funds, “which may indicate structural issues.”

    Lagging private contributions

    The ECA also observed, once again, that contributions from private partners were falling short for several JUs.

    Under the current long-term budget, through to 2027, the total financial resources for the JUs excluding F4E amount to around €38.5 billion, of which some €17.2 billion comes from the EU. The plan was to have other members contribute up to 123% of EU money, namely €21.3 million.

    Although this is much lower than the 158% target set under the 2014-20 budget, the JUs have on average achieved only 26% of this objective so far.

    Most notably, the European High Performance Computing JU had reached just 0.3% of its €900 million target for 2021-27 at the end of last year. This “threatens the achievement of its overall programme objective to have a strong cooperation with private partners,” the ECA says.

    In the case of the Single European Sky Air Traffic Management Research 3 JU, which aims to modernise air traffic management, the contribution from the European Organisation for the Safety of Air Navigation, its international founding member, stood at 16% of a €500-million under Horizon Europe. The same goes for the Global Health EDCTP3 JU, which has obtained 4% of a promised €400 million, for lack of sufficient contributing partners.

    According to the ECA, this can be partly explained by the slow start of the 2021-27 programmes.

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  • Sex Differences and Androgen Regulation Shape Mucosal Immune Phenotype

    Sex Differences and Androgen Regulation Shape Mucosal Immune Phenotype

    Introduction

    Rheumatoid arthritis (RA) is a chronic autoimmune disorder with an unclear etiology. It is characterized by progressive joint inflammation, pain, and deformities. In advanced stages, these manifestations can lead to functional…

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  • COAS Munir’s tenure to restart after appointment as CDF

    COAS Munir’s tenure to restart after appointment as CDF

    Chief of Army Staff (COAS) Field Marshal Asim Munir. — PPI/File

    Chief of Army Staff (COAS) Field Marshal Asim Munir’s tenure will be…

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  • Pakistan’s 27th Constitutional Amendment Bill now law: How it makes Asim Munir more powerful, weakens Supreme Court | Explained News

    Pakistan’s 27th Constitutional Amendment Bill now law: How it makes Asim Munir more powerful, weakens Supreme Court | Explained News

    Pakistan’s President Asif Ali Zardari on Thursday (November 13) signed the 27th Constitutional Amendment Bill, making it part of Pakistan’s Constitution. The controversial Bill significantly increases the powers of the Field Marshal Asim…

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  • Pathophysiological Consequences of Hormonal Contraceptives in Sub-Saha

    Pathophysiological Consequences of Hormonal Contraceptives in Sub-Saha

    Introduction

    In sub-Saharan Africa (SSA), family planning is crucial for public health and socioeconomic development, as high fertility rates and rapid population growth lead to increased maternal and child mortality, strain on the healthcare…

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  • Marina Lewycka, British-Ukrainian author, dies aged 79 | Books

    Marina Lewycka, British-Ukrainian author, dies aged 79 | Books

    The British-Ukrainian novelist Marina Lewycka, best known for her comic debut A Short History of Tractors in Ukrainian, has died aged 79 from a degenerative brain condition, her agent has confirmed.

    Lewycka’s fiction often drew on her Ukrainian…

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  • US government opens back up but deep political divisions remain – Reuters

    1. US government opens back up but deep political divisions remain  Reuters
    2. Trump signs spending bill to end longest shutdown in US history  BBC
    3. Trump signs deal to end longest US government shutdown in history  Dawn
    4. US Senate passes bill to end…

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