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  • One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

    One-time CRISPR therapy safely lowers cholesterol and triglycerides in early trial

    In a 15-patient, Phase 1 one, first-in-human trial, a one-time, CRISPR-Cas9 gene-editing therapy safely reduced LDL cholesterol and triglycerides in people with difficult-to-treat lipid disorders, according to a preliminary…

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  • AI is back — it never really went away

    AI is back — it never really went away

    Jakub Porzycki | Nurphoto | Getty Images

    Investors piled back into artificial intelligence names on Monday stateside. Shares of Nvidia jumped 5.8%, Broadcom advanced 2.6% and Microsoft climbed 1.9% to end its eight-day losing streak, its longest consecutive decline since 2011.

    Market watchers are hoping that another historically long streak — the U.S. government shutdown — could soon be snapped as well. As of this newsletter's publication time, lawmakers in the U.S. Senate are voting on a deal to reopen the government, though it still has to pass through the House and then signed into law by President Donald Trump (who has already given it his approval).

    That's not to say worries about AI's high valuations have gone away completely.

    CoreWeave on Monday reported its third-quarter earnings. It rents out Nvidia cards to AI-related firms, such as Google and Microsoft, a business model that ties it intimately to the AI trade. The company's revenue swelled 134% year on year, but it still reported a net loss and gave lower-than-expected guidance for this year.

    The general shape of those figures — high revenue and high losses — broadly reminds one of OpenAI, the industry-leading, money-bleeding startup that kickstarted the AI frenzy. Though it would of course be a stretch to equate the two companies and the factors driving their finances.

    Still, Mark Haefele, CIO of UBS's global wealth management, thinks "AI-related stocks should drive equity markets." With the U.S. government shutdown in sight to end (hopefully this doesn't jinx it), that's another obstacle surpassed for markets.

    What you need to know today

    And finally...

    Russian President Vladimir Putin on October 15, 2025.

    Alexander Zemlianichenko | Afp | Getty Images

    Russia is late to the party, but it's still preparing to enter the rare earths fray

    Russian President Vladimir Putin last week ordered his officials to complete a road map by Dec.1 "for the long-term development of the extraction and production of rare and rare earth metals."

    Moscow has fallen behind peers like China when it comes to the exploitation of its deposits of rare earth elements. While lagging behind the big players, Russia is still estimated to possess the fifth largest known reserves of rare earths, totaling 3.8 million tonnes, the United States Geological Survey stated. That's above the U.S. which is seen with 1.9 million tonnes.

    — Holly Ellyatt


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  • Delhi explosion: India police exploring ‘all possibilities’ after Red Fort blast kills eight

    Delhi explosion: India police exploring ‘all possibilities’ after Red Fort blast kills eight

    Verifying images from Red Fort, New Delhipublished at 16:41 GMT 10 November

    Media caption,

    Verified videos show aftermath of explosion in Delhi

    By Joshua Cheetham, Richard Irvine-Brown, Shruti Menon

    Just before 14:00 GMT…

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  • BR Research: Rising remittance dependence – Business Recorder

    1. BR Research: Rising remittance dependence  Business Recorder
    2. Remittances hit $3.4bn in October  Dawn
    3. Let them fly  The News International
    4. Saudi Arabia leads remittances as inflows rise 11.9% to $3.4 billion in October  Arab News PK
    5. ACE Money Transfer…

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  • BR Research: Rising remittance dependence – Business Recorder

    1. BR Research: Rising remittance dependence  Business Recorder
    2. Remittances hit $3.4bn in October  Dawn
    3. Let them fly  The News International
    4. Saudi Arabia leads remittances as inflows rise 11.9% to $3.4 billion in October  Arab News
    5. Remittances rise 12%…

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  • Oscar Isaac says he would only do Star Wars again if Disney doesn’t ‘succumb to fascism’ | Oscar Isaac

    Oscar Isaac says he would only do Star Wars again if Disney doesn’t ‘succumb to fascism’ | Oscar Isaac

    Oscar Isaac has said he is “not so open to working with Disney” in the wake of Jimmy Kimmel’s suspension, with the Star Wars actor saying he’d only consider working with Disney again if the company doesn’t “succumb to fascism”.

    Asked…

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  • Drug breakthrough could substantially slow progression of motor neurone disease, say scientists | UK News

    Drug breakthrough could substantially slow progression of motor neurone disease, say scientists | UK News

    Scientists have discovered a new medicine that they say offers hope of substantially slowing the progress of motor neurone disease (MND).

    The drug, named M102, works by protecting nerve cells damaged by MND.

    Preclinical studies of…

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  • China taps potential of new tech application scenarios to boost economic growth

    BEIJING, Nov. 10 — China is seeking to drive high-quality economic development by exploring further application scenarios for new technologies and products, with the aim of promoting their large-scale industrial application and development, and accelerating the development of emerging industries.

    At a policy briefing in Beijing on Monday, Li Chunlin, deputy head of the National Development and Reform Commission, said that scenarios have become key innovation resources, defining the term “scenario” as a bridge that connects technology and industry, and that links research and development with the market.

    The briefing was delivered by officials of multiple government departments and came after the General Office of the State Council publicized a related set of guidelines last week.

    Li said the guidelines have specified efforts to explore and develop new application scenarios on five major fronts: the digital economy and artificial intelligence; industrial transformation and upgrading in sectors such as manufacturing and transport; industries such as mining and emergency response; social governance services; and public welfare.

    He said that these measures will provide opportunities for private capital and private enterprises to participate in the development of scenarios, and revealed that central government funding will be provided to support eligible infrastructure projects that serve major application scenarios.

    Also speaking at the briefing, Ministry of Industry and Information Technology official Yao Jun said that the ministry attaches great importance to nurturing scenarios, and it will work to accelerate the exploration of application scenarios in a wide range of fields by utilizing 5G, AI, robotics, industrial internet and BeiDou navigation technologies.

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  • Animal Crossing: New Horizons sails ashore with a Nintendo Switch 2 Edition and free content update coming 15th January – Nintendo

    1. Animal Crossing: New Horizons sails ashore with a Nintendo Switch 2 Edition and free content update coming 15th January  Nintendo
    2. Animal Crossing: New Horizons comes to Nintendo Switch 2 with new features  Paris Select Book
    3. Animal Crossing’s big…

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  • Gabriele Münter’s Groundbreaking Modernist Vision Is Coming into Focus

    Gabriele Münter’s Groundbreaking Modernist Vision Is Coming into Focus

    Art

    Portrait of Gabriele Münter, 1903. Photo by Robert Beyschlag. Image via Wikimedia Commons.

    Gabriele Münter, Still Life on the Tram (After Shopping), ca. 1909–12. © 2025 Artists Rights Society (ARS), New York / VG Bild-Kunst, Bonn. Courtesy…

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