Author: admin

  • Jorrel Hato: Chelsea agree deal for Ajax defender in potential eighth signing of summer

    Jorrel Hato: Chelsea agree deal for Ajax defender in potential eighth signing of summer

    Chelsea have agreed a deal for Ajax defender Jorrel Hato for an initial fee of £37m, subject to the Dutch club’s supervisory board approval.

    The 19-year-old Dutchman is expected to sign a seven-year contract lasting until 2032 and will complete a medical, having been given the green light to travel to west London.

    Chelsea consider Hato a talented young option to add competition to the backline, where he is capable of playing at either left-back or in central defence.

    Hato made his senior debut for Ajax in February 2023 at just 16 years and 335 days old, making him the third-youngest player ever to feature in an Eredivisie game for the club

    He has made 75 appearances for the Eredivisie side and made his senior debut for the Netherlands in 2023.

    Ajax have decided to sell him, with a need to raise funds after a two-year hiatus from the substantial revenues of the Champions League. They will return to Europe’s top-tier competition this season.

    Chelsea are believed to be close to finishing their summer business but remain in the market for another attacker, having held talks with the representatives of RB Leipzig’s Xavi Simons without making a formal bid.

    They are also aiming to make further player sales with Christopher Nkunku likely to leave, as well as an openness to sell striker Nicolas Jackson for the right price.

    There also remains a squad of unwanted players training separately from Enzo Maresca’s first team, including Raheem Sterling, Ben Chilwell, Renato Veiga, Axel Disasi, Carney Chukwuemeka, Armando Broja and Lesley Ugochukwu.

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  • IIF/ISDA Response to BoE Consultation on Banks’ and Insurers’ Management of Climate-related Risks > The Institute of International Finance

    IIF/ISDA Response to BoE Consultation on Banks’ and Insurers’ Management of Climate-related Risks > The Institute of International Finance

    On July 30, the Institute of International Finance (IIF) and International Swaps and Derivatives Association (ISDA), on behalf of their respective global financial services industry members, submitted comments on the Bank of England’s Consultation Paper 10/25, “Enhancing banks’ and insurers’ approaches to managing climate-related risks – Update to SS3/19”.

    IIF and ISDA members welcome the Bank of England’s thoughtful and iterative approach to climate-related financial risk management over the past several years. We agree that industry practices and global standards have evolved since the release of SS3/19. However, climate risk assessment and management are extremely complex and evolving fields, so it is understandable that many firms across the industry are still working to further develop their understanding and approach.

    Members support the PRA’s stated approach of considering climate-related factors as drivers of potential financial risks; however, there are certain proposals set out in the consultation that appear to deviate from this view and may require revision. More generally, the PRA could better demonstrate that it sees climate-related risk drivers as one component of wider risk management and governance.

    We welcome the PRA’s intention to take a proportionate and risk-based approach, which is based on the materiality of climate-related financial risks to a firm, and provide suggestions on how this can be clearer and more explicit in the revised Supervisory Statement. 

    We observe that the PRA’s draft Supervisory Statement is significantly more detailed than the current SS3/19. In general, our members believe that the PRA’s approach has not become excessively prescriptive, which is welcomed.

    The letter details specific feedback on each chapter of the PRA consultation paper, including on climate scenario analysis expectations, climate targets, data and implementation.

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  • Query Fan-Out Technique in AI Mode: New Details From Google

    Query Fan-Out Technique in AI Mode: New Details From Google

    In a recent interview, Google’s VP of Product for Search, Robby Stein, shared new information about how query fan-out works in AI Mode.

    Although the existence of query fan-out has been previously detailed in Google’s blog posts, Stein’s comments expand on its mechanics and offer examples that clarify how it works in practice.

    Background On Query Fan-Out Technique

    When a person types a question into Google’s AI Mode, the system uses a large language model to interpret the query and then “fan out” multiple related searches.

    These searches are issued to Google’s infrastructure and may include topics the user never explicitly mentioned.

    Stein said during the interview:

    “If you’re asking a question like things to do in Nashville with a group, it may think of a bunch of questions like great restaurants, great bars, things to do if you have kids, and it’ll start Googling basically.”

    He described the system as using Google Search as a backend tool, executing multiple queries and combining the results into a single response with links.

    This functionality is active in AI Mode, Deep Search, and some AI Overview experiences.

    Scale And Scope

    Stein said AI-powered search experiences, including query fan-out, now serve approximately 1.5 billion users each month. This includes both text-based and multimodal input.

    The underlying data sources include traditional web results as well as real-time systems like Google’s Shopping Graph, which updates 2 billion times per hour.

    He referred to Google Search as “the largest AI product in the world.”

    Deep Search Behavior

    In cases where Google’s systems determine a query requires deeper reasoning, a feature called Deep Search may be triggered.

    Deep Search can issue dozens or even hundreds of background queries and may take several minutes to complete.

    Stein described using it to research home safes, a purchase he said involved unfamiliar factors like fire resistance ratings and insurance implications.

    He explained:

    “It spent, I don’t know, like a few minutes looking up information and it gave me this incredible response. Here are how the ratings would work and here are specific safes you can consider and here’s links and reviews to click on to dig deeper.”

    AI Mode’s Use Of Internal Tools

    Stein mentioned that AI Mode has access to internal Google tools, such as Google Finance and other structured data systems.

    For example, a stock comparison query might involve identifying relevant companies, pulling current market data, and generating a chart.

    Similar processes apply to shopping, restaurant recommendations, and other query types that rely on real-time information.

    Stein stated:

    “We’ve integrated most of the real-time information systems that are within Google… So it can make Google Finance calls, for instance, flight data… movie information… There’s 50 billion products in the shopping catalog… updated I think 2 billion times every hour or so. So all that information is able to be used by these models now.”

    Technical Similarities To Google’s Patent

    Stein described a process similar to a Google patent from December about “thematic search.”

    The patent outlines a system that creates sub-queries based on inferred themes, groups results by topic, and generates summaries using a language model. Each theme can link to source pages, but summaries are compiled from multiple documents.

    This approach differs from traditional search ranking by organizing content around inferred topics rather than specific keywords. While the patent doesn’t confirm implementation, it closely matches Stein’s description of how AI Mode functions.

    Looking Ahead

    With Google explaining how AI Mode generates its own searches, the boundaries of what counts as a “query” are starting to blur.

    This creates challenges not just for optimization, but for attribution and measurement.

    As search behavior becomes more fragmented and AI-driven, marketers may need to focus less on ranking for individual terms and more on being included in the broader context AI pulls from.

    Listen to the full interview below:

    Featured Image: Screenshot from youtube.com/@GoogleDevelopers, July 2025. 

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  • Longitude Prize on ALS Encourages Using AI To Find New Treatments – Asian Scientist Magazine

    AsianScientist (Jul. 30, 2025) – A new £7.5 million (~$10 million) Longitude Prize on ALS has been announced to incentivise the use of AI to accelerate therapeutic discovery for the treatment of amyotrophic lateral sclerosis (ALS), the most common form of motor neurone disease (MND).

    The challenge, open for entries from June 25, 2025, until December 3, 2025, will initially award 20 teams £100,000 each in early 2026, with one team going on to win £1 million at the end of the five year Prize.

    The Prize is principally funded by the Motor Neurone Disease Association and designed and delivered by Challenge Works, supported by Nesta, alongside additional global funders.

    What is ALS?

     ALS is a fatal neurodegenerative disease with an average life expectancy post-diagnosis of just two to four years. It is the most common form of Motor Neurone Disease (MND), in which messages from the motor neurones gradually stop reaching the muscles. This leads the muscles to weaken, stiffen and waste, which can affect how individuals walk, talk, eat, drink and breathe.

    Although some very limited treatments exist to slow the progression of ALS for a short time, the complexity of the disease means that there are no long-term treatments and no cure. For the first time, however, advances in AI mean innovators now have the opportunity to potentially outpace the disease by unlocking vast quantities of patient data that have been generated in the last decade.

    “Never before have we had the power to unlock the complexity of MND, and in particular ALS, and accelerate along the road to long-term treatments, and, I hope one day, a cure,” said Tris Dyson, managing director at Challenge Works, who was diagnosed with ALS in 2023.

    “The Longitude Prize on ALS makes this possible, convening the largest data set of ALS patient data of its kind ever made available and rewarding researchers to use AI to identify the most promising drug targets,” Dyson added.

    The five-year Prize will see global multidisciplinary teams compete in a three-phased programme to identify, prioritise and validate high-potential drug targets for ALS. To drive discovery, the Prize has brought together a range of ALS datasets, working with data holders worldwide, and participants will be provided with access to these data, funding, technical expertise and a range of additional support and partnership opportunities.

    Who they are looking for

    The Prize will award applicants from across medical research, biotechnology, computational biology and AI, and will support the top 20 most promising applications who show high potential in both their proposed methodology and team make-up, which should bring together expertise from across multiple disciplines including ALS research and computational biology.

    “Empowering some of the brightest minds across science and technology to come together, the Longitude Prize on ALS will initiate transformative change for people living with motor neurone disease,” said Tanya Curry, Chief Executive at the Motor Neurone Disease Association.

     “We are investing as a principal funder as enabling such collaborations, as well as the level of unprecedented data we’re working to unlock, marks the start of a significant milestone for drug discovery, the MND Association and wider MND community in how we understand and consequently tackle the disease,” Curry added.

    The Longitude Prize on ALS is the third Longitude Prize run by Challenge Works to incentivise breakthrough solutions for some of the world’s most challenging issues. It follows the success of the Longitude Prize on AMR that announced a winner in 2024, and the Longitude Prize on Dementia that will announce a winner in 2026.

    —

    Source: Longitude Prize on ALS ; Image: Longitude Prize on ALS

    Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.


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  • Jeremy Renner Teases MCU Return, ‘Hawkeye’ Season 2

    Jeremy Renner Teases MCU Return, ‘Hawkeye’ Season 2

    Jeremy Renner is preparing for his return to the Marvel Cinematic Universe. 

    In an interview with Empire magazine, published on Tuesday, the Hawkeye star admitted that he’s “sure we’ll end up doing season two” of the Disney+ series that spotlighted his longtime character Clint Barton (aka Hawkeye). His comments about returning to the MCU come after he previously revealed he turned down another season of Hawkeye after being offered half of his salary for a second season. 

    “I’m always happy to be in that world, man. … I love all those guys, I love the character,” he said of portraying Clint/Hawkeye in the superhero film franchise. “I’m sure we’ll end up doing season two, and do other things. And I’m happy to do it.” 

    When the Oscar nominee revealed his proposed salary cuts for season two of Hawkeye, he clarified that the offer came after his near-fatal snowplow accident. 

    “I’m like, wow, it’s going to take me twice the amount of work for half the amount of money — eight months of my time, essentially, and you do it for half the amount?” he said in May. “I’m like, ‘I’m sorry, why? Did you think I’m only half the Jeremy because I got ran over?’ Is that why want to pay me half of what I made on the first season?”

    Following the 2023 snowplow accident, where he was “pronounced dead on the ice,” Renner added that he’s getting his body prepped for the physical demands that come with portraying Clint/Hawkeye.

    “My body’s getting ready for something like that,” he said. “I don’t know if anybody wants to see me in tights, but my body will look good in the tights.” 

    The My Next Breath author, too, noted that in the wake of the harrowing accident, he’s prioritized having “health and wellness be such a central part of my life,” attributing his lifestyle to his recovery. 

    “I’m more than 150 percent of what I was prior to the incident,” he added. “Having health and wellness be such a central part of my life, that’s what’s gotten me back. And even as I age, I just feel stronger than I’ve been. I have some issues, and tendon issues and certain limitations of flexibility and mobility, but I spent a lot of time on getting better and stronger, and I wouldn’t if I didn’t get crushed.” 

    Renner debuted the character of Clint/Hawkeye in 2012’s The Avengers. He was last seen in the role via archival footage in the 2024 Disney+ series Echo. Season one of Hawkeye aired in 2021.

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  • Why More Pro Lifters in 2025

    Why More Pro Lifters in 2025

    New York City, NY, July 30, 2025 (GLOBE NEWSWIRE) — CrazyBulk is leading the 2025 muscle-building evolution with what many experts consider the best SARMs for cutting and bulking legally available – no injections, no dangerous side effects, just powerful, safe body transformation.

    The New Era of Bodybuilding: From Risky Steroid Compounds to Legal SARMs

    The bodybuilding industry is undergoing a seismic shift in priorities. For decades, people wanting muscle, strength, and razor-sharp definition often meant making tough choices between performance and health.

    But as science advances and regulations tighten, the next generation of pro and amateur lifters is demanding more: they want real results without risking their long-term well-being.

    At the epicenter of this evolution is the rise of legal SARMs alternatives – a new class of supplements that promise the muscle-building and fat-burning power of traditional anabolic agents, but with a focus on safety, legal compliance, and natural ingredients. And when it comes to legal SARMs, one name stands at the forefront: CrazyBulk.

    CrazyBulk has firmly established itself as the market leading SARMs company in the USA and worldwide, earning a reputation for excellence with its safe, legal, and natural alternatives to the most sought-after selective androgen receptor modulators.

    View SARMS bulking stack for rapid muscle growth

    Weight lifters, Bodybuilders and professional athletes trust CrazyBulk for their cutting-edge muscle supplements inspired by RAD 140 (Testolone), Ostarine 2866, Ligadrol LGD 4033, and Ibutamoren MK 677.

    Unlike conventional SARMs, CrazyBulk’s formulas deliver the muscle-building, fat-cutting, and performance-boosting benefits of these powerhouse compounds—without the legal risks, side effects, or need for a prescription.

    With rigorous quality standards, transparent ingredient sourcing, and a proven track record of global customer satisfaction, CrazyBulk continues to lead the industry as the go-to provider for anyone looking for safe, effective SARMs for muscle growth, fat loss, and total body transformation.

    What Are SARMs and Why Do Bodybuilders Want Them?

    SARMs, or Selective Androgen Receptor Modulators, were originally developed as a way to harness the muscle-building benefits of anabolic steroids while minimizing undesirable side effects. 

    Unlike classic steroids, SARMs target specific androgen receptors in muscle and bone tissue, theoretically resulting in enhanced muscle growth, strength, and fat loss with fewer risks.

    However, unregulated SARMs have been plagued by health concerns, legal restrictions, and purity issues. As a result, the demand for safe, legal, and effective alternatives has never been higher—especially among elite athletes who refuse to compromise their careers or health.

    CrazyBulk: The Trusted Name in Legal SARMs Alternatives

    CrazyBulk has long been recognized as a leader in natural, legal performance supplements. In 2025, the brand has solidified its reputation by launching a comprehensive line of legal SARMs alternatives – formulas designed to help bodybuilders and athletes achieve their goals without the downsides of banned or synthetic substances.

    With over 500,000 bottles sold and a global customer base, CrazyBulk’s SARMs alternatives have rapidly become the go-to choice for professional lifters, physique competitors, and fitness enthusiasts who want results that last.

    Why Pro Lifters Are Switching to Legal SARMs Alternatives

    1. Regulatory Compliance and Peace of Mind

    For competitive athletes, the risk of testing positive for banned substances is career-ending. CrazyBulk’s SARMs alternatives are 100% legal and designed to comply with international anti-doping regulations. 

    Each formula is crafted from natural ingredients, thoroughly tested for purity, and guaranteed free of synthetic SARMs, hormones, or illegal compounds.

    2. Science-Driven Results Without Compromise

    The muscle-building supplements market has seen its share of hype and empty promises. CrazyBulk’s legal SARMs alternatives are different. Built on a foundation of peer-reviewed research and real-world user feedback, these products are formulated to:

    • Build lean muscle mass
    • Increase strength and power
    • Accelerate fat loss
    • Support natural testosterone production
    • Enhance recovery and endurance

    3. No Needles, No Side Effects, No Prescription

    Traditional anabolic steroids and unregulated SARMs often require injections, post-cycle therapy, and come with a laundry list of potential side effects—from hormonal imbalances to liver strain. 

    CrazyBulk SARMs alternatives are oral supplements with zero known side effects, no prescription required, and no need for complicated cycles.

    Inside the Formula: How CrazyBulk’s SARMs Alternatives Deliver Next-Level Results

    A Lineup Tailored for Every Phase: Bulking, Cutting, and Strength

    CrazyBulk legal SARMs alternatives are engineered for every stage of the bodybuilding journey:

    Best SARM for Bulking: Monster Muscle Growth and Strength

    TESTOL 140 – RAD 140 (Testolone)

    If you’re looking to pack on serious muscle and power, TESTOL 140 is a must have. A powerful RAD 140 (Testolone) SARM, this natural muscle builder is all about helping your body boost its own testosterone—the key hormone behind rapid muscle growth, strength, and fast recovery. 

    TESTOL 140 makes it easier for athletes and gym-goers to smash through their plateaus and see real, noticeable gains. People using it often talk about lifting heavier, working out harder, and bouncing back quicker after intense sessions. Best of all, you get all these benefits without the risks that come with synthetic anabolic agents.

    IBUTA 677 – MK 677 (Ibutamoren)

    Ever wish you could tap into your body’s natural muscle-building potential? IBUTA 677 is modeled after MK 677 (Ibutamoren) and works by supporting your natural human growth hormone (HGH) levels. The result? Fuller muscles, more visible veins, and muscle gains that come quicker than you might expect. 

    What really sets IBUTA 677 apart is how it helps you get better, deeper sleep—so your muscles repair and grow even while you rest. For anyone serious about bulking up and staying strong, this supplement helps you build muscle and strength in a way that feels natural and sustainable.

    LIGAN 4033 – LGD 4033 (Ligandrol)

    When your goal is to outlast everyone else in the gym, LIGAN 4033 is for endurance. A legal version LGD 4033 (Ligandrol) SARM, this formula is all about boosting endurance and muscle performance. It works by increasing blood flow and getting more oxygen to your muscles, which means you experience bigger pumps and less fatigue during tough workouts. 

    People who use LIGAN 4033 say they can go harder for longer, crank out more reps, and recover faster between sets. If you want to maximize your results during a bulking phase and push your body to new limits, this is the supplement to have in your corner.

    Best SARM for Cutting: Shredded, Lean Physique

    C-DINE 501516 – GW 501516 (Cardarine)

    If getting lean and showing off real muscle definition is your goal, C-DINE 501516 is made for you. Based on GW 501516 (Cardarine), this supplement is all about firing up your body’s fat-burning engine. 

    It helps increase fat oxidation and revs up your metabolism, so you burn more calories—even when you’re not working out. 

    What sets C-DINE 501516 apart is how it goes after stubborn fat, especially in those hard-to-lose areas, while making sure you don’t lose your hard-earned muscle. It’s a top pick for competitive bodybuilders and anyone looking to cut down for summer, a photoshoot, or just to feel their best in lean shape.

    STENA 9009 – SR 9009 (Stenabolic)

    When you need to keep your energy high and your workouts intense, STENA 9009 is the SARM of choice. A safe alternative to SR 9009 (Stenabolic), this formula is perfect for boosting endurance, stamina, and blood flow, especially during tough cutting cycles. 

    Think of it as your secret weapon for powering through cardio sessions or demanding high-intensity intervals. STENA 9009 helps your body burn more fat for fuel while making sure you stay motivated and energetic, not run-down. It’s ideal for anyone who wants to stay sharp, focused, and athletic while getting shredded.

    OSTA 2866 – MK 2866 (Ostarine)

    If you want to get lean without sacrificing any muscle, OSTA 2866—the legal version of MK 2866 (Ostarine)—is the answer. This supplement is legendary for helping you hold onto muscle size and strength, even when you’re cutting calories hard. It’s a real muscle-saver, protecting your gains so you don’t lose all your hard work when you shed body fat. 

    Plus, OSTA 2866 is known to support your joints and help with recovery, which really matters during intense training or dieting phases. For anyone chasing that defined, athletic look but wanting to stay strong and injury-free, OSTA 2866 is a must-have.

    For All-Out Performance: Ultimate Stacks

    Cutting SARMS Stack includes legal versions of MK677, Cardarine, Stenabolic SR9009 and Ligandrol.

    View SARMS Cutting Stack price and availability

    For those who want maximum results, CrazyBulk offers bulking, cutting, and ultimate stacks—carefully curated bundles that combine the benefits of multiple SARMs alternatives for synergistic muscle growth, strength, and fat loss.

    The Science Behind the Supplements: 100% Natural, Athlete-Tested, and Proven

    Ingredient Integrity: Nature’s Most Powerful Performance Boosters

    What sets CrazyBulk’s SARMs alternatives apart is their commitment to legal ingredients with proven efficacy. Each product is free from synthetic SARMs, steroids, or hormones. Instead, formulas are built on:

    • Herbal extracts known for boosting testosterone and growth hormone
    • Adaptogens for improved endurance and stress resilience
    • Thermogenic agents for enhanced fat burning
    • Amino acids and micronutrients to promote muscle repair and recovery

    Selective Androgen Receptor Modulators Quality Control and Transparency

    Every batch of CrazyBulk’s SARMs alternatives is subjected to rigorous testing for potency and purity. All products are manufactured in GMP-certified facilities and come with transparent labeling—so you know exactly what you’re putting into your body.

    From the Pros: Real Results, Real Transformations

    Trusted by Elite Bodybuilders and Everyday Lifters Alike

    CrazyBulk’s SARMs alternatives aren’t just for the stage. They’re trusted by:

    • IFBB pros looking for a legal edge
    • Powerlifters seeking sustainable strength
    • CrossFit athletes demanding stamina and muscle preservation
    • Busy professionals who want to maximize gym results without legal or health risks

    Success Stories and Before/After Transformations

    With hundreds of thousands of bottles sold and a global community of satisfied users, CrazyBulk’s social media is filled with before-and-after photos, testimonials, and real-world success stories. Many pro lifters report:

    • Noticeable muscle gain within 4–6 weeks
    • Improved strength and performance
    • Faster recovery between intense sessions
    • Leaner, more defined physiques during cutting cycles
    • Zero side effects or hormonal crashes

    The End of the “Old School Anabolic Steroids” Era: Why Today’s Bodybuilders Want Legal SARMs

    Changing Priorities: From Size at Any Cost to Sustainable Performance

    In the past, bodybuilding was dominated by a “bigger is better” mentality—often at the expense of long-term health. But in 2025, priorities are shifting. More professional athletes now value:

    • Sustainable gains over short-lived bulks
    • Functional strength and stamina for real-world performance
    • Drug-tested compliance for career longevity
    • Low-risk, accessible supplementation

    CrazyBulk’s SARMs alternatives are perfectly matched to this new era, delivering performance nutrition that works for both competition and everyday life.

    Stacking Strategies: How Pro Lifters Cycle Legal SARMs Alternatives for Best Results

    The Power of Synergy: Stacks That Amplify Results

    One of the most effective ways to maximize results with CrazyBulk’s SARMs alternatives is through stacking—using complementary products together to target multiple aspects of muscle growth, fat loss, and performance.

    Bulking Stack (Building Muscle Size)

    • TESTOL 140 + IBUTA 677 + LIGAN 4033
      This powerful trio supports muscle hypertrophy, strength gains, and hormonal balance for all-out growth phases.

    Cutting Stack (Muscle Preservation and Fat Loss)

    • C-DINE 501516 + STENA 9009 + OSTA 2866
      Designed to preserve hard-earned muscle while shedding fat, this stack is ideal for pre-contest prep or summer shredding.

    Ultimate SARMs Stack (Bulking, Cutting and Strength Gains)

    • Combine all six SARMs alternatives for a comprehensive cycle that maximizes muscle, strength, and leanness.

    Cycle Lengths and Best Practices

    Most pro lifters follow a 6–8 week cycle with a 1–2 week break between stacks. During this time, users are encouraged to:

    • Maintain a high-protein, nutrient-dense diet
    • Prioritize sleep and recovery
    • Stay hydrated
    • Track progress and adjust dosage as needed

    CrazyBulk provides detailed stack guides, dosage instructions, and cycle planners with every purchase, making it easy to optimize your approach.

    Safety First: How CrazyBulk Sets a New Standard for Legal SARMs Alternatives

    Zero Compromises on Health or Legality

    Unlike underground SARMs or black-market steroids, CrazyBulk’s alternatives are:

    • 100% legal in all countries
    • Free from banned substances
    • Suitable for both men and women
    • Non-habit forming
    • No prescription required

    This makes them a safe bet for anyone—pro or amateur—seeking elite results without regulatory or health headaches.

    No Hidden Ingredients, No Side Effects

    Every formula is free from synthetics, fillers, and harsh chemicals. Users report zero known side effects, no hormonal crashes, and no need for complicated post-cycle therapy.

    Next-Level Convenience: Global Shipping, Money-Back Guarantee, and Support

    • Fast, free shipping on orders over $100 to more than 100 countries
    • Secure checkout and all major credit cards accepted
    • Buy 2, Get 1 Free and stack savings on all major bundles
    • 60-day money-back guarantee for risk-free trials
    • Dedicated support and product guidance from the CrazyBulk team

    Who Should Use Legal SARMs Alternatives?

    Pro Athletes and Competitors

    For those in drug-tested sports, legal SARMs alternatives are the gold standard for muscle, strength, and definition—without risking disqualification.

    Lifters Over 30

    Aging athletes face declining testosterone and slower recovery. SARMS like TESTOL 140 and IBUTA 677 help bridge the gap, supporting muscle retention, stamina, and energy.

    Women in Strength Sports

    CrazyBulk’s SARMs alternatives are suitable for women seeking lean muscle, strength, and cutting support—without masculinizing side effects.

    Fitness Enthusiasts and Beginners

    Beginners and recreational lifters can safely use these products to fast-track results, boost confidence, and break through plateaus.

    How to Get Started: Your Roadmap to Bigger, Stronger, and Leaner in 2025

    Step 1: Define Your Goal

    Are you looking to bulk up, shred fat, or maximize all-around performance? CrazyBulk’s online product finder quiz and customer support can guide you to the right stack.

    Step 2: Choose Your Stack or Individual Product

    • Bulking? Try the SARMs Bulking Stack.
    • Cutting? Opt for the SARMs Cutting Stack.
    • Want it all? Go for the Ultimate SARMs Stack.

    Step 3: Follow the Plan

    • Take your supplements as directed.
    • Stick to your training and nutrition plan.
    • Monitor your progress and adjust as needed.

    Step 4: Enjoy Real Results—No Compromises

    Join the ranks of pro lifters and fitness enthusiasts worldwide who are achieving record gains, faster recovery, and superior body composition—all while staying safe and legal.

    Frequently Asked Questions (FAQ)

    1. Are CrazyBulk’s dietary supplements safe for long-term use?
    Yes, CrazyBulk’s dietary supplements are made from natural ingredients and rigorously tested for safety. They are designed to avoid common issues like liver toxicity and are free from synthetic selective androgen receptor modulators (SARMs) or androgenic anabolic steroids.

    2. Can CrazyBulk products help increase muscle mass without the risks of traditional SARMs like Rad 140?
    Absolutely. CrazyBulk’s formulas are crafted to stimulate muscle growth and increase muscle mass, offering a natural alternative to compounds like Rad 140, but without concerns like testosterone suppression or liver toxicity.

    3. Are CrazyBulk’s supplements legal and FDA approved?
    CrazyBulk’s dietary supplements are legal and available without a prescription. However, as with most bodybuilding supplements, the FDA warns these products are not intended to diagnose, treat, cure, or prevent any disease.

    4. Will these supplements show up on drug tests?
    No, CrazyBulk’s products do not contain banned selective androgen receptor modulators or androgenic anabolic steroids, making them suitable for drug-tested athletes focused on performance enhancement.

    5. How do these supplements support body fat reduction and fat oxidation?
    CrazyBulk’s legal alternatives are designed to promote fat oxidation and body fat reduction while helping to preserve or increase muscle mass, which is essential for those aiming for a leaner physique.

    6. Is there a risk of testosterone suppression with CrazyBulk’s legal alternatives?
    No, the natural ingredients in CrazyBulk’s supplements are formulated to avoid the risk of testosterone suppression, a common concern with traditional SARMs like ostarine mk 2866 or Rad 140.

    7. Do I need to stack or cycle these dietary supplements for best results?
    While each supplement is effective on its own, stacking recommended products can increase bulking and cutting goals such as muscle growth, body fat reduction, and fat oxidation. Most users follow 6–8 week cycles with breaks.

    8. Are there any known risks of liver toxicity associated with CrazyBulk SARMS?
    Unlike traditional androgenic anabolic steroids and some selective androgen receptor modulators, CrazyBulk’s legal alternatives are designed to avoid liver toxicity, ensuring safer long-term use.

    9. How quickly can I expect to see improvements in muscle mass and performance?
    Many users report noticeable increases in muscle mass and improved fat oxidation within 4–6 weeks, especially when combined with a consistent training regimen and healthy dietary habits.

    10. Are CrazyBulk’s products suitable alternatives to ostarine mk 2866 or Rad 140 for lean muscle growth?
    Yes, CrazyBulk’s legal supplements are positioned as safe, effective alternatives to compounds like ostarine mk 2866 and Rad 140. They support performance enhancement and muscle growth without the regulatory or health risks associated with traditional SARMs.

    Final Summary: The Future of Bodybuilding Is Legal, Safe, and Effective

    The days of high-risk shortcuts and questionable compounds are coming to an end. In 2025, elite athletes and fitness enthusiasts have a better choice—one that delivers the muscle, strength, and definition they crave, without the dangers of traditional SARMs or steroids.

    CrazyBulk legal SARMs alternatives are leading this revolution, offering real results that are safe, sustainable, and fully compliant with sports regulations. Whether you’re a pro chasing your next title, a lifter seeking your personal best, or anyone committed to long-term fitness, it’s time to experience the CrazyBulk advantage.

    The era of legal muscle building SARMs is here. Are you ready to build, cut, and conquer—without compromise?

    Disclaimer: The information provided in this article is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting any supplement regimen. Individual results may vary.

    Media Contact:
    Steve Niddich, Head of Product Innovation
    CrazyBulk
    244 Madison Avenue, New York City, NY 10016-2817
    Email: support@crazybulk.com
    Phone: +1 888-708-6394
    Website: https://crazybulk.com

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  • The next Xbox may target 4K gaming at 120 fps and could arrive next year

    The next Xbox may target 4K gaming at 120 fps and could arrive next year

    With Microsoft making everything an Xbox, and a move to branded partnerships like the ROG Xbox Ally handheld, it might feel surprising that the company is still working on a next generation console.

    A new leak from YouTuber Moore’s Law is Dead, claims that Microsoft is going all-in on graphics for its next Xbox console, and it could launch within the next two years. As reported by Notebookcheck, the next Xbox console could have double the performance and visual fidelity of the PS5 Pro.

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  • Quantification of Antiretroviral Drug Presences in Breastmilk

    Quantification of Antiretroviral Drug Presences in Breastmilk

    Key Points

    • Human immunodeficiency virus (HIV) can occasionally be spread via breastmilk, although antiretroviral drugs can drastically shrink the risk of transmission.
    • It is currently unknown if antiretroviral drugs can linger in breastmilk.
    • To answer this, researchers modified an ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method to detect certain protein levels in plasma.

    To better detect drug residues in breastmilk, Radboud University Medical Center personnel (Nijmegen, The Netherlands) modified an ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) method to detect certain proteins in milk. Their findings were published in the Journal of Chromatography B (1).

    Human immunodeficiency virus (HIV) is a virus that attacks cells that help the body fight infection, making people more vulnerable to other infections and diseases (2). While typically transmitted through blood or sexual activity, HIV can also be spread via breastmilk. However, recent studies have shown that the risk of breastmilk transmission shrinks drastically when viral replication is suppressed with the continuous and effective use of antiretroviral drugs. This process, known as antiretroviral therapy (ART), makes the risk of transmission through breastfeeding less than 1% (3). Guidelines have adjusted as a result, but one remaining question is if exposure to antiretroviral drugs through breastmilk is an issue of concern. To answer this, accurate bioanalytical methods are required.

    To develop such a method, there are challenges with breastmilk as a matrix. As an emulsion, breastmilk’s phases can be influenced by temperature and repeated freezing and thawing. It contains multiple lipids, proteins, and carbohydrates. The composition of breastmilk varies over time (colostrum vs mature milk), during each feeding (fore- and hindmilk), during the day and is also affected by maternal dietary intakes. These factors need to be considered when developing a method for quantifying drug concentrations in breastmilk.

    In this study, the scientists modified an UHPLC–MS/MS method typically used for anti-HIV drugs in plasma. It was enabled for validation of dolutegravir, bictegravir, raltegravir, and doravirine concentrations in human breastmilk. [13C,2H5]-Dolutegravir, [13C,2H2,15N]-bictegravir, [2H6]-raltegravir and [13C6]-doravirine were used as internal standard. The sample preparation involved protein precipitation and detection was performed with tandem mass spectrometry (MS/MS) in a total runtime of 10 min.

    The assay was validated over the concentration ranges of 0.0100–10.0 mg/L for dolutegravir and doravirine, 0.00500–10.0 mg/L for raltegravir and 0.0200–20.0 mg/L for bictegravir. Within-run and between-run accuracy were within ±10 % of the nominal concentration and precision <10 CV% for quality controls at high, medium and low concentrations, and ± 8.8 % and < 14 CV%, respectively, at the lower limit of quantification for all analytes. Extraction recovery was 81% and 79% for dolutegravir and its internal standard, 83% and 83% for bictegravir and its internal standard, 89% and 92% for raltegravir and its internal standard and 104% and 101% for doravirine and its internal standard. Processed samples of dolutegravir, bictegravir, raltegravir and doravirine in breastmilk were 108%, 95.5%, 105% and 102% after 14 days at 4 °C.

    While the composition of breastmilk changes over time, dolutegravir, bictegravir, raltegravir and doravirine concentrations in human breastmilk could accurately and reproducibly validated using the UHPLC–MS/MS bioanalytical method in this study. For simultaneously quantification of plasma, the method could be used alongside a simple protein precipitation work-up with adapted preparation of calibration standards and quality control samples in breastmilk.

    References

    (1) Van der Wekken, P. L. C.; van Ewijk, B. K. E. W. J.; te Brake, L. H. M.; Burger, D. M. Quantification of Dolutegravir, Bictegravir, Raltegravir and Doravirine in Human Breastmilk with UPLC-MS/MS. J. Chromatogr. B 2025, 1264, 124739. DOI: 10.1016/j.jchromb.2025.124739

    (2) What are HIV and AIDS? HIV.gov 2023. https://www.hiv.gov/hiv-basics/overview/about-hiv-and-aids/what-are-hiv-and-aids (accessed 2025-7-30)

    (3) HIV and Breastfeeding. CDC 2025. https://www.cdc.gov/breastfeeding-special-circumstances/hcp/illnesses-conditions/hiv.html (accessed 2025-7-30)

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  • Why More Pro Lifters in 2025 Trust CrazyBulk’s Safe Alternatives to Gain Muscle, Increase Strength and Cutting

    Why More Pro Lifters in 2025 Trust CrazyBulk’s Safe Alternatives to Gain Muscle, Increase Strength and Cutting

    CrazyBulk

    CrazyBulk

    New York City, NY, July 30, 2025 (GLOBE NEWSWIRE) — CrazyBulk is leading the 2025 muscle-building evolution with what many experts consider the best SARMs for cutting and bulking legally available – no injections, no dangerous side effects, just powerful, safe body transformation.

    The New Era of Bodybuilding: From Risky Steroid Compounds to Legal SARMs

    The bodybuilding industry is undergoing a seismic shift in priorities. For decades, people wanting muscle, strength, and razor-sharp definition often meant making tough choices between performance and health.

    But as science advances and regulations tighten, the next generation of pro and amateur lifters is demanding more: they want real results without risking their long-term well-being.

    At the epicenter of this evolution is the rise of legal SARMs alternatives – a new class of supplements that promise the muscle-building and fat-burning power of traditional anabolic agents, but with a focus on safety, legal compliance, and natural ingredients. And when it comes to legal SARMs, one name stands at the forefront: CrazyBulk.

    CrazyBulk has firmly established itself as the market leading SARMs company in the USA and worldwide, earning a reputation for excellence with its safe, legal, and natural alternatives to the most sought-after selective androgen receptor modulators.

    View SARMS bulking stack for rapid muscle growth

    Weight lifters, Bodybuilders and professional athletes trust CrazyBulk for their cutting-edge muscle supplements inspired by RAD 140 (Testolone), Ostarine 2866, Ligadrol LGD 4033, and Ibutamoren MK 677.

    Unlike conventional SARMs, CrazyBulk’s formulas deliver the muscle-building, fat-cutting, and performance-boosting benefits of these powerhouse compounds—without the legal risks, side effects, or need for a prescription.

    With rigorous quality standards, transparent ingredient sourcing, and a proven track record of global customer satisfaction, CrazyBulk continues to lead the industry as the go-to provider for anyone looking for safe, effective SARMs for muscle growth, fat loss, and total body transformation.

    What Are SARMs and Why Do Bodybuilders Want Them?

    SARMs, or Selective Androgen Receptor Modulators, were originally developed as a way to harness the muscle-building benefits of anabolic steroids while minimizing undesirable side effects.

    Unlike classic steroids, SARMs target specific androgen receptors in muscle and bone tissue, theoretically resulting in enhanced muscle growth, strength, and fat loss with fewer risks.

    However, unregulated SARMs have been plagued by health concerns, legal restrictions, and purity issues. As a result, the demand for safe, legal, and effective alternatives has never been higher—especially among elite athletes who refuse to compromise their careers or health.

    CrazyBulk: The Trusted Name in Legal SARMs Alternatives

    CrazyBulk has long been recognized as a leader in natural, legal performance supplements. In 2025, the brand has solidified its reputation by launching a comprehensive line of legal SARMs alternatives – formulas designed to help bodybuilders and athletes achieve their goals without the downsides of banned or synthetic substances.

    With over 500,000 bottles sold and a global customer base, CrazyBulk’s SARMs alternatives have rapidly become the go-to choice for professional lifters, physique competitors, and fitness enthusiasts who want results that last.

    Why Pro Lifters Are Switching to Legal SARMs Alternatives

    1. Regulatory Compliance and Peace of Mind

    For competitive athletes, the risk of testing positive for banned substances is career-ending. CrazyBulk’s SARMs alternatives are 100% legal and designed to comply with international anti-doping regulations.

    Each formula is crafted from natural ingredients, thoroughly tested for purity, and guaranteed free of synthetic SARMs, hormones, or illegal compounds.

    2. Science-Driven Results Without Compromise

    The muscle-building supplements market has seen its share of hype and empty promises. CrazyBulk’s legal SARMs alternatives are different. Built on a foundation of peer-reviewed research and real-world user feedback, these products are formulated to:

    • Build lean muscle mass

    • Increase strength and power

    • Accelerate fat loss

    • Support natural testosterone production

    • Enhance recovery and endurance

    3. No Needles, No Side Effects, No Prescription

    Traditional anabolic steroids and unregulated SARMs often require injections, post-cycle therapy, and come with a laundry list of potential side effects—from hormonal imbalances to liver strain.

    CrazyBulk SARMs alternatives are oral supplements with zero known side effects, no prescription required, and no need for complicated cycles.

    Inside the Formula: How CrazyBulk’s SARMs Alternatives Deliver Next-Level Results

    A Lineup Tailored for Every Phase: Bulking, Cutting, and Strength

    CrazyBulk legal SARMs alternatives are engineered for every stage of the bodybuilding journey:

    Best SARM for Bulking: Monster Muscle Growth and Strength

    TESTOL 140 – RAD 140 (Testolone)

    If you’re looking to pack on serious muscle and power, TESTOL 140 is a must have. A powerful RAD 140 (Testolone) SARM, this natural muscle builder is all about helping your body boost its own testosterone—the key hormone behind rapid muscle growth, strength, and fast recovery.

    TESTOL 140 makes it easier for athletes and gym-goers to smash through their plateaus and see real, noticeable gains. People using it often talk about lifting heavier, working out harder, and bouncing back quicker after intense sessions. Best of all, you get all these benefits without the risks that come with synthetic anabolic agents.

    IBUTA 677 – MK 677 (Ibutamoren)

    Ever wish you could tap into your body’s natural muscle-building potential? IBUTA 677 is modeled after MK 677 (Ibutamoren) and works by supporting your natural human growth hormone (HGH) levels. The result? Fuller muscles, more visible veins, and muscle gains that come quicker than you might expect.

    What really sets IBUTA 677 apart is how it helps you get better, deeper sleep—so your muscles repair and grow even while you rest. For anyone serious about bulking up and staying strong, this supplement helps you build muscle and strength in a way that feels natural and sustainable.

    LIGAN 4033 – LGD 4033 (Ligandrol)

    When your goal is to outlast everyone else in the gym, LIGAN 4033 is for endurance. A legal version LGD 4033 (Ligandrol) SARM, this formula is all about boosting endurance and muscle performance. It works by increasing blood flow and getting more oxygen to your muscles, which means you experience bigger pumps and less fatigue during tough workouts.

    People who use LIGAN 4033 say they can go harder for longer, crank out more reps, and recover faster between sets. If you want to maximize your results during a bulking phase and push your body to new limits, this is the supplement to have in your corner.

    Best SARM for Cutting: Shredded, Lean Physique

    C-DINE 501516 – GW 501516 (Cardarine)

    If getting lean and showing off real muscle definition is your goal, C-DINE 501516 is made for you. Based on GW 501516 (Cardarine), this supplement is all about firing up your body’s fat-burning engine.

    It helps increase fat oxidation and revs up your metabolism, so you burn more calories—even when you’re not working out.

    What sets C-DINE 501516 apart is how it goes after stubborn fat, especially in those hard-to-lose areas, while making sure you don’t lose your hard-earned muscle. It’s a top pick for competitive bodybuilders and anyone looking to cut down for summer, a photoshoot, or just to feel their best in lean shape.

    STENA 9009 – SR 9009 (Stenabolic)

    When you need to keep your energy high and your workouts intense, STENA 9009 is the SARM of choice. A safe alternative to SR 9009 (Stenabolic), this formula is perfect for boosting endurance, stamina, and blood flow, especially during tough cutting cycles.

    Think of it as your secret weapon for powering through cardio sessions or demanding high-intensity intervals. STENA 9009 helps your body burn more fat for fuel while making sure you stay motivated and energetic, not run-down. It’s ideal for anyone who wants to stay sharp, focused, and athletic while getting shredded.

    OSTA 2866 – MK 2866 (Ostarine)

    If you want to get lean without sacrificing any muscle, OSTA 2866—the legal version of MK 2866 (Ostarine)—is the answer. This supplement is legendary for helping you hold onto muscle size and strength, even when you’re cutting calories hard. It’s a real muscle-saver, protecting your gains so you don’t lose all your hard work when you shed body fat.

    Plus, OSTA 2866 is known to support your joints and help with recovery, which really matters during intense training or dieting phases. For anyone chasing that defined, athletic look but wanting to stay strong and injury-free, OSTA 2866 is a must-have.

    For All-Out Performance: Ultimate Stacks

    Cutting SARMS Stack includes legal versions of MK677, Cardarine, Stenabolic SR9009 and Ligandrol.

    View SARMS Cutting Stack price and availability

    For those who want maximum results, CrazyBulk offers bulking, cutting, and ultimate stacks—carefully curated bundles that combine the benefits of multiple SARMs alternatives for synergistic muscle growth, strength, and fat loss.

    The Science Behind the Supplements: 100% Natural, Athlete-Tested, and Proven

    Ingredient Integrity: Nature’s Most Powerful Performance Boosters

    What sets CrazyBulk’s SARMs alternatives apart is their commitment to legal ingredients with proven efficacy. Each product is free from synthetic SARMs, steroids, or hormones. Instead, formulas are built on:

    • Herbal extracts known for boosting testosterone and growth hormone

    • Adaptogens for improved endurance and stress resilience

    • Thermogenic agents for enhanced fat burning

    • Amino acids and micronutrients to promote muscle repair and recovery

    Selective Androgen Receptor Modulators Quality Control and Transparency

    Every batch of CrazyBulk’s SARMs alternatives is subjected to rigorous testing for potency and purity. All products are manufactured in GMP-certified facilities and come with transparent labeling—so you know exactly what you’re putting into your body.

    From the Pros: Real Results, Real Transformations

    Trusted by Elite Bodybuilders and Everyday Lifters Alike

    CrazyBulk’s SARMs alternatives aren’t just for the stage. They’re trusted by:

    • IFBB pros looking for a legal edge

    • Powerlifters seeking sustainable strength

    • CrossFit athletes demanding stamina and muscle preservation

    • Busy professionals who want to maximize gym results without legal or health risks

    Success Stories and Before/After Transformations

    With hundreds of thousands of bottles sold and a global community of satisfied users, CrazyBulk’s social media is filled with before-and-after photos, testimonials, and real-world success stories. Many pro lifters report:

    • Noticeable muscle gain within 4–6 weeks

    • Improved strength and performance

    • Faster recovery between intense sessions

    • Leaner, more defined physiques during cutting cycles

    • Zero side effects or hormonal crashes

    The End of the “Old School Anabolic Steroids” Era: Why Today’s Bodybuilders Want Legal SARMs

    Changing Priorities: From Size at Any Cost to Sustainable Performance

    In the past, bodybuilding was dominated by a “bigger is better” mentality—often at the expense of long-term health. But in 2025, priorities are shifting. More professional athletes now value:

    • Sustainable gains over short-lived bulks

    • Functional strength and stamina for real-world performance

    • Drug-tested compliance for career longevity

    • Low-risk, accessible supplementation

    CrazyBulk’s SARMs alternatives are perfectly matched to this new era, delivering performance nutrition that works for both competition and everyday life.

    Stacking Strategies: How Pro Lifters Cycle Legal SARMs Alternatives for Best Results

    The Power of Synergy: Stacks That Amplify Results

    One of the most effective ways to maximize results with CrazyBulk’s SARMs alternatives is through stacking—using complementary products together to target multiple aspects of muscle growth, fat loss, and performance.

    Bulking Stack (Building Muscle Size)

    • TESTOL 140 + IBUTA 677 + LIGAN 4033
      This powerful trio supports muscle hypertrophy, strength gains, and hormonal balance for all-out growth phases.

    Cutting Stack (Muscle Preservation and Fat Loss)

    Ultimate SARMs Stack (Bulking, Cutting and Strength Gains)

    • Combine all six SARMs alternatives for a comprehensive cycle that maximizes muscle, strength, and leanness.

    Cycle Lengths and Best Practices

    Most pro lifters follow a 6–8 week cycle with a 1–2 week break between stacks. During this time, users are encouraged to:

    • Maintain a high-protein, nutrient-dense diet

    • Prioritize sleep and recovery

    • Stay hydrated

    • Track progress and adjust dosage as needed

    CrazyBulk provides detailed stack guides, dosage instructions, and cycle planners with every purchase, making it easy to optimize your approach.

    Safety First: How CrazyBulk Sets a New Standard for Legal SARMs Alternatives

    Zero Compromises on Health or Legality

    Unlike underground SARMs or black-market steroids, CrazyBulk’s alternatives are:

    • 100% legal in all countries

    • Free from banned substances

    • Suitable for both men and women

    • Non-habit forming

    • No prescription required

    This makes them a safe bet for anyone—pro or amateur—seeking elite results without regulatory or health headaches.

    No Hidden Ingredients, No Side Effects

    Every formula is free from synthetics, fillers, and harsh chemicals. Users report zero known side effects, no hormonal crashes, and no need for complicated post-cycle therapy.

    Next-Level Convenience: Global Shipping, Money-Back Guarantee, and Support

    • Fast, free shipping on orders over $100 to more than 100 countries

    • Secure checkout and all major credit cards accepted

    • Buy 2, Get 1 Free and stack savings on all major bundles

    • 60-day money-back guarantee for risk-free trials

    • Dedicated support and product guidance from the CrazyBulk team

    Who Should Use Legal SARMs Alternatives?

    Pro Athletes and Competitors

    For those in drug-tested sports, legal SARMs alternatives are the gold standard for muscle, strength, and definition—without risking disqualification.

    Lifters Over 30

    Aging athletes face declining testosterone and slower recovery. SARMS like TESTOL 140 and IBUTA 677 help bridge the gap, supporting muscle retention, stamina, and energy.

    Women in Strength Sports

    CrazyBulk’s SARMs alternatives are suitable for women seeking lean muscle, strength, and cutting support—without masculinizing side effects.

    Fitness Enthusiasts and Beginners

    Beginners and recreational lifters can safely use these products to fast-track results, boost confidence, and break through plateaus.

    How to Get Started: Your Roadmap to Bigger, Stronger, and Leaner in 2025

    Step 1: Define Your Goal

    Are you looking to bulk up, shred fat, or maximize all-around performance? CrazyBulk’s online product finder quiz and customer support can guide you to the right stack.

    Step 2: Choose Your Stack or Individual Product

    • Bulking? Try the SARMs Bulking Stack.

    • Cutting? Opt for the SARMs Cutting Stack.

    • Want it all? Go for the Ultimate SARMs Stack.

    Step 3: Follow the Plan

    • Take your supplements as directed.

    • Stick to your training and nutrition plan.

    • Monitor your progress and adjust as needed.

    Step 4: Enjoy Real Results—No Compromises

    Join the ranks of pro lifters and fitness enthusiasts worldwide who are achieving record gains, faster recovery, and superior body composition—all while staying safe and legal.

    Frequently Asked Questions (FAQ)

    1. Are CrazyBulk’s dietary supplements safe for long-term use?
    Yes, CrazyBulk’s dietary supplements are made from natural ingredients and rigorously tested for safety. They are designed to avoid common issues like liver toxicity and are free from synthetic selective androgen receptor modulators (SARMs) or androgenic anabolic steroids.

    2. Can CrazyBulk products help increase muscle mass without the risks of traditional SARMs like Rad 140?
    Absolutely. CrazyBulk’s formulas are crafted to stimulate muscle growth and increase muscle mass, offering a natural alternative to compounds like Rad 140, but without concerns like testosterone suppression or liver toxicity.

    3. Are CrazyBulk’s supplements legal and FDA approved?
    CrazyBulk’s dietary supplements are legal and available without a prescription. However, as with most bodybuilding supplements, the FDA warns these products are not intended to diagnose, treat, cure, or prevent any disease.

    4. Will these supplements show up on drug tests?
    No, CrazyBulk’s products do not contain banned selective androgen receptor modulators or androgenic anabolic steroids, making them suitable for drug-tested athletes focused on performance enhancement.

    5. How do these supplements support body fat reduction and fat oxidation?
    CrazyBulk’s legal alternatives are designed to promote fat oxidation and body fat reduction while helping to preserve or increase muscle mass, which is essential for those aiming for a leaner physique.

    6. Is there a risk of testosterone suppression with CrazyBulk’s legal alternatives?
    No, the natural ingredients in CrazyBulk’s supplements are formulated to avoid the risk of testosterone suppression, a common concern with traditional SARMs like ostarine mk 2866 or Rad 140.

    7. Do I need to stack or cycle these dietary supplements for best results?
    While each supplement is effective on its own, stacking recommended products can increase bulking and cutting goals such as muscle growth, body fat reduction, and fat oxidation. Most users follow 6–8 week cycles with breaks.

    8. Are there any known risks of liver toxicity associated with CrazyBulk SARMS?
    Unlike traditional androgenic anabolic steroids and some selective androgen receptor modulators, CrazyBulk’s legal alternatives are designed to avoid liver toxicity, ensuring safer long-term use.

    9. How quickly can I expect to see improvements in muscle mass and performance?
    Many users report noticeable increases in muscle mass and improved fat oxidation within 4–6 weeks, especially when combined with a consistent training regimen and healthy dietary habits.

    10. Are CrazyBulk’s products suitable alternatives to ostarine mk 2866 or Rad 140 for lean muscle growth?
    Yes, CrazyBulk’s legal supplements are positioned as safe, effective alternatives to compounds like ostarine mk 2866 and Rad 140. They support performance enhancement and muscle growth without the regulatory or health risks associated with traditional SARMs.

    Final Summary: The Future of Bodybuilding Is Legal, Safe, and Effective

    The days of high-risk shortcuts and questionable compounds are coming to an end. In 2025, elite athletes and fitness enthusiasts have a better choice—one that delivers the muscle, strength, and definition they crave, without the dangers of traditional SARMs or steroids.

    CrazyBulk legal SARMs alternatives are leading this revolution, offering real results that are safe, sustainable, and fully compliant with sports regulations. Whether you’re a pro chasing your next title, a lifter seeking your personal best, or anyone committed to long-term fitness, it’s time to experience the CrazyBulk advantage.

    The era of legal muscle building SARMs is here. Are you ready to build, cut, and conquer—without compromise?

    Disclaimer: The information provided in this article is for educational purposes only and does not constitute medical advice. Always consult a healthcare professional before starting any supplement regimen. Individual results may vary.

    Media Contact:
    Steve Niddich, Head of Product Innovation
    CrazyBulk
    244 Madison Avenue, New York City, NY 10016-2817
    Email: support@crazybulk.com
    Phone: +1 888-708-6394
    Website: https://crazybulk.com

    Attachment

    CONTACT: Media Contact: Steve Niddich, Head of Product Innovation CrazyBulk 244 Madison Avenue, New York City, NY 10016-2817 Email: support@crazybulk.com Phone: +1 888-708-6394 Website: https://crazybulk.com

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  • Belzutifan Shows Superior Quality-Adjusted Survival in Advanced RCC

    Belzutifan Shows Superior Quality-Adjusted Survival in Advanced RCC

    Data from the LITESPARK-005 Q-TWiST analysis show belzutifan’s improved quality-adjusted survival time and favorable toxicity profile vs everolimus in RCC.

    In a presentation at the 2025 Kidney Cancer Research Summit, Thomas Powles, MBBS, MCRP, MD, spoke with CancerNetwork® about the results of a Quality-Adjusted Time Without Symptoms or Toxicity (Q-TWiST) analysis from the phase 3 LITESPARK-005 trial (NCT04195750) comparing belzutifan (Welireg) with everolimus (Afinitor) in patients who were heavily pretreated with clear cell renal cell carcinoma.1

    LITESPARK-005 was a randomized phase 3 study designed to evaluate belzutifan, a HIF-2 alpha inhibitor, against everolimus in this patient population. Although previous findings from LITESPARK-005 showed a high response rate and improved progression-free survival (PFS) with belzutifan, an overall survival advantage was not demonstrated. However, the Q-TWiST analysis showed that belzutifan exhibited a distinct toxicity profile and correlated with better overall quality of life.

    The rationale behind conducting this Q-TWiST analysis was to gain a more nuanced understanding of patient benefit beyond traditional endpoints like PFS. According to Powles, this analysis is crucial because while PFS indicates the duration patients are progression-free, it does not account for the impact of treatment-related toxicities on their quality of life. By integrating quality-of-life questionnaires, Q-TWiST may provide a valuable perspective on the patient experience by focusing on the period without progression and without toxicity.

    The findings from this analysis showed that belzutifan outperformed everolimus due to a longer time to progression and a longer time without toxicity, which was deemed clinically meaningful.

    Powles is a professor of genitourinary oncology, lead for Solid Tumor Research, and director of Barts Cancer Institute at St. Bartholomew’s Hospital at Queen Mary University of London.

    What was the background for conducting this Q-TWiST analysis among patients who received everolimus or belzutifan in the LITESPARK-005 trial?

    LITESPARK-005 was a big, randomized phase 3 study. It tested belzutifan vs everolimus in patients who were heavily pretreated with advanced clear cell renal cancer. Belzutifan is a HIF-2 alpha inhibitor. It’s well tolerated. It’s an agent that is associated with anemia, some hypoxia, and fatigue. Compared with VEGF tyrosine kinase inhibitors [TKIs], in my clinical experience, it’s well tolerated. [The trial] showed high response and better PFS [with belzutifan]. We didn’t show an overall survival advantage. We showed a distinct toxicity profile, and we also showed better overall quality of life [with belzutifan].

    In this Q-TWiST analysis we performed, what we were looking at was the time that the patients had without progression and without significant toxicity. That’s essentially what it is; PFS just looks at progression and the area of patients who are progression-free, which is great, but if all that time was spent with significant toxicity, that means less than if a patient has the same amount of time without [PFS] with no toxicity. We can construct Kaplan-Meier curves, and within those curves, we can define specific areas: those areas without progression and [with] toxicity, those areas without progression and without toxicity, and those areas after progression. In the Q-TWiST analysis, specifically, we look at that time, that period, and that area without progression and without toxicity, and then we bring in the quality-of-life questionnaires to work out what, in terms of that area, the quality of life is during that period. That’s the Q of Q-TWiST.

    That’s a summary of how it works. Essentially, it’s not a surprise that belzutifan outperformed everolimus in this respect quite significantly. The time to progression was longer, the area was therefore larger, and the time without toxicity was longer. That was clinically meaningful by previous parameters, which had been set to perform Q-TWiST analysis.

    What did findings show about the quality-adjusted survival time in patients who received belzutifan vs everolimus in this population?

    The story behind belzutifan, so far, is an agent that has been developed in 2 areas that are contrasting with each other. No. 1 is Von Hippel-Lindau [VHL]–driven disease, and that disease has shown that renal tumors can be put into remission or regression associated with belzutifan, preventing surgery on primary renal tumors. That’s important for patients. In the other extreme, in metastatic clear cell renal cancer, we go all the way where it’s been developed very late: the third or fourth line, in many cases. Those 2 are very different from each other. The development of the disease—the VHL disease—and how that relates to patients who are very heavily pretreated is quite complicated. It’s probable, or even likely, that if we use belzutifan earlier in the disease process, it will work better. What we’ve shown with this Q-TWiST analysis is not only that it is more active than everolimus, but it appears to be, from a quality-of-life perspective and a time-dependent quality of life analysis, to be better tolerated, making it an attractive [option].

    What are the next steps for researching belzutifan or other therapeutic agents among patients with previously treated advanced renal cell carcinoma?

    The story of belzutifan is a long one, and looking forward into the future, there are several randomized trials [that are ongoing]. There’s the adjuvant [phase 3 LITESPARK-022 study (NCT05239728)], and as I said before, [belzutifan] might work better earlier in the disease.2 Pembrolizumab [Keytruda] plus or minus belzutifan in patients who are high-risk post-surgery is No.1. It’s in the frontline setting….It’s also [being assessed] in a randomized phase 3 trial [NCT04586231] in patients who received 1 prior therapy, essentially second-line treatment, which is lenvatinib plus belzutifan vs cabozantinib [Cabometyx].3 [There is] a plethora of randomized trials earlier in the disease and big randomized studies. Belzutifan has a promising future, and because it’s well tolerated, that makes it an attractive combination.

    What do you hope others take away from your presentation?

    The main goal for them would be to say the analysis confirms our impression and our clinical experience that belzutifan is well tolerated. My personal experience is that it’s true. These data should not come as a surprise to anyone that our Q-TWiST analysis for belzutifan is better than everolimus, and I hope that they also see it as not just an attractive option in patients who are heavily pretreated, which is the case. If you switch away from VEGF TKIs to belzutifan, what you’ll find is that the toxicity profile—the chronic fatigue and diarrhea associated with VEGF TKIs—can be switched off by [choosing belzutifan]. It does have a role to play. I accept it doesn’t have an overall survival signal by itself. The response, the [PFS], the quality of life, and these Q-TWiST data give a compelling argument for this being an attractive agent in patients who are heavily pretreated.

    References

    1. Powles T, de Velasco G, Choueiri TK, et al. Quality-adjusted time without symptoms or toxicity (Q-TWiST) analysis of belzutifan versus everolimus in previously treated advanced renal cell carcinoma (RCC): LITESPARK-005 (LS-005). Presented at the 2025 Kidney Cancer Research Summit; July 17-18, 2025; Boston, MA. Abstract 13.
    2. A study of belzutifan (MK-6482) plus pembrolizumab (MK-3475) versus placebo plus pembrolizumab in participants with clear cell renal cell carcinoma post nephrectomy (MK-6482-022). ClinicalTrials.gov. Updated July 17, 2025. Accessed July 22, 2025. https://tinyurl.com/y69wn2xb
    3. A study of belzutifan (MK-6482) in combination with lenvatinib versus cabozantinib for treatment of renal cell carcinoma (MK-6482-011). ClinicalTrials.gov. Updated April 2, 2025. Accessed July 22, 2025. https://tinyurl.com/mtftnfpt

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