- PCSK9 Inhibitor Found Effective for Primary Prevention Medscape
- Amgen cholesterol drug cuts risk of first cardiac event by 25% Reuters
- Evolocumab lowers risk for first major cardiovascular events Healio
- Taher Modarressi Highlights VESALIUS Trial as Standout of AHA25 Lipid Session Oncodaily
- PCSK9 inhibitor reduced major CVD events in adults with no prior heart attack or stroke www.heart.org
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PCSK9 Inhibitor Found Effective for Primary Prevention – Medscape
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Jupiter’s volcanic moon Io is burning much hotter than expected
Jupiter’s volcanic moon has always felt like a place that tests your sense of what a world can be. Its surface glows with hundreds of active hot spots. Its mountains rise higher than Everest. Its lava lakes pulse and fracture as if the ground…
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Dermatologists clarify difference between dry skin, eczema
With the change of seasons and the fall in temperature, many people face common skin problems such as dryness and eczema, conditions often mistaken for one another.
Reduced water intake during cold weather further…
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Dermatologists clarify difference between dry skin, eczema
With the change of seasons and the fall in temperature, many people face common skin problems such as dryness and eczema, conditions often mistaken for one another.
Reduced water intake during cold weather further…
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Final farewell: Google’s first Pixel Watch receives its last minor update
What you need to know
- Original 2022 Pixel Watch receives final software update with security fixes but no major upgrades.
- Update BW1A.251005.003.W1 maintains device on Wear OS 5.1, closing window for major system support.
- Google continues app…
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Huawei Mate 70 Air, RedMagic 11 Pro official, S26 Unpacked leaks, Week 45 in review
Samsung’s upcoming S26 series is rumored to come later than its predecessor, and the latest report suggests that Samsung will hold the all-important Unpacked event on February 25.
Speaking of the Galaxy S26 series, the latest intel on the…
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Novak Djokovic withdraws from ATP Finals due to shoulder injury | Football News
Seven-times ATP Finals champion Novak Djokovic has withdrawn from the season-ending tournament due to a shoulder injury, hours after winning his 101st title at the Hellenic Championship.
Finalist Lorenzo Musetti will take his place in Turin,…
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CoreWeave earnings: 5 key details to watch as the stock eyes a turnaround
By Christine Ji
CoreWeave’s stock has tumbled recently, but some analysts think a massive surge in backlogged contracts could spark a comeback
CoreWeave signed several large contracts with companies like Meta and Nvidia in the third quarter.
Shares of CoreWeave Inc. have been battered in recent months over concerns about the sustainability of the company’s growth. But unceasing artificial-intelligence momentum might just reignite enthusiasm for the company as it reports third-quarter earnings on Monday.
Wall Street analysts will be on the lookout for five clues in particular for investors that a comeback may be in the works.
CoreWeave (CRWV), which provides specialized cloud infrastructure for some of the biggest tech companies in the market, has been a critical part of the AI buildout. However, the stock performance has been volatile. While CoreWeave shares surged in the initial months after the company’s initial public offering back in March of this year, they’ve fallen over 30% since the company reported second-quarter earnings on Aug. 13.
The price drop isn’t necessarily a bad thing. Jefferies analyst Brent Thill wrote in a note last week that CoreWeave’s stock currently has a “very attractive” risk-reward profile. His $180 price target implies about 75% upside from current levels.
According to Thill, the “biggest focus” for CoreWeave’s earnings will be on the company’s remaining performance obligations, or the future revenue from contracts not yet fulfilled. During the third quarter, CoreWeave signed several multibillion-dollar contracts with customers such as OpenAI, Meta Platforms Inc. (META) and Nvidia Corp. (NVDA), which Thill believes could raise its RPO to $60 billion, from $30 billion last quarter.
Read: Will CoreWeave bears get burned? New Nvidia deals spark fresh optimism for the stock.
One concern that CoreWeave bears have pointed out is the company’s dependence on a few large customers. Monday’s earnings report could offer increased visibility on CoreWeave’s customer mix.
“As demand is only seeming to increase, we continue to see a strong possibility for acceleration in [fiscal 2026] with a safer strategy as management pushes for customer diversification and longer five- to six-year contracts,” Citi analyst Tyler Radke wrote in a recent note.
Radke raised his price target on the stock to $192 from $164 ahead of earnings, citing continued demand for AI computing, especially from CoreWeave’s Big Tech customers.
Thill and Radke will be also be looking for commentary surrounding CoreWeave’s access to power, which has been a critical bottleneck. CoreWeave Chief Executive Michael Intrator shared in a Bloomberg interview last month that the company had secured 2.8 gigawatts of contracted power, up 600 megawatts from the second quarter.
Increased access to power and more large-scale contracts should help CoreWeave execute on its demand backlog and lead to “outsized” revenue beats in excess of $100 million in the third and fourth quarters, Radke wrote. The Citi analyst anticipates that CoreWeave will report $1.3 billion in revenue for the third quarter, a 124% year-over-year increase. The Wall Street analyst consensus for revenue is lower, at $1.21 billion.
Investors will also be curious about CoreWeave’s capital-expenditure plans, as the company has spent aggressively so far in 2025 to build more AI infrastructure. Radke expects a significant quarter-over-quarter increase in capex spend, especially as CoreWeave continues to ramp up deployment of Nvidia’s Blackwell chips in light of the new deal announcements.
CoreWeave’s capital-intensive business does pose a potential risk to the stock price, as the company has taken on a significant debt load and could need to issue more debt in the future. The useful life of CoreWeave’s data-center assets could also be shorter than expected, which would erode into margins. Last quarter, CoreWeave reported a larger-than-expected adjusted net loss, due to high infrastructure spending.
As a result of its capex spend, Radke believes investors shouldn’t expect CoreWeave to be profitable in the near term. However, he is optimistic that it will post a smaller net loss than Wall Street is expecting this quarter, and anticipates that the company will have “significant profitability improvements” late next year and into 2027.
Also read: CoreWeave’s stock has been red hot, but this rival may be a better investment
-Christine Ji
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
(END) Dow Jones Newswires
11-09-25 1200ET
Copyright (c) 2025 Dow Jones & Company, Inc.
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The bull market in stocks – and the ‘buy everything’ rally – now feel like an uphill battle
By Joy Wiltermuth
Tech and speculative assets are now in focus after the Nasdaq’s worst week since April
The “buy everything” rally since April now feels like an uphill battle.
It doesn’t feel like a “buy everything” market anymore.
Last week’s sharp pullback in tech stocks could easily turn into yet another buy-the-dip moment in the week ahead, like other times since April’s tariff-induced market plunge.
Bitcoin’s (BTCUSD) brush up against a new bear market could also prove fleeting, and the recent sharp selloff in other speculative corners of the market that began in late October might easily reverse.
Yet this moment seems a bit different – as though markets might be more fragile, and investors could be less inclined to simply stomp on the gas pedal at the first sign of any pullback.
“You aren’t going to get the timing right,” said Jim Baird, chief investment officer at Plante Moran Financial Advisors. “I’m not trying to guess what’s going to happen over the next week or month.” But the recent pain in areas that have “run a little hotter” is indicating that investors “are taking a little bit more cautious approach to the rally from April’s lows,” he said.
It’s been a pretty solid run for risk assets, Baird noted. But there have been cracks in credit markets, talk of more credit “cockroaches,” and other ominous indicators keeping investors on edge, in addition to a glaring “blind spot” in economic data during the ongoing, historic government shutdown.
“It isn’t as if everything is coming up roses,” Baird said of the rally since April. “Whether it’s economic, policy or geopolitical risks, there’s a lot for investors to absorb.”
Read: The shutdown is starting to ‘bite the economy,’ top Trump aide warns. The Senate is struggling to make a deal.
AI froth in focus
November typically ends up being a strong month for the stock market. But missed paychecks, nationwide flight cancellations and other ramifications of the government shutdown have paved the way for an unsteady start to the month.
The Nasdaq Composite COMP retreated 3% last week, logging its worst week since the early April tariff tumult, while the S&P 500 SPX shed 1.6% and the Dow Jones Industrial Average DJIA closed the week 1.2% lower, according to Dow Jones Market Data.
The pullback wasn’t terribly surprising. The S&P 500 remains up nearly 15% on the year despite higher tariffs, growing doubts about the job market and a fresh reading on the mood of U.S. consumers showing sentiment neared a record low in November.
Overall solid corporate earnings also didn’t prevent jitters around stock valuations and artificial-intelligence spending plans from returning, as well as concerns about when large tech companies might earn a return on those AI investments.
A look at the five top “hyperscalers” shows spending could hit $600 billion in two years at Amazon.com Inc. (AMZN), Microsoft Corp. (MSFT), Google parent Alphabet Inc. (GOOGL) (GOOG), Meta Platforms Inc. (META) and Oracle Corp. (ORCL), according to Thomas Shipp, head of equity research at LPL Financial.
Spending by five top “hyperscalers” in the AI race is projected to hit $600 billion in 2027
“I’m not worried about the AI capex spend,” said Bryant VanCronkhite, a senior equity portfolio manager at Allspring Global Investments. Despite “moments” when markets can pull back quickly, he said he’s more focused on the long-term opportunity.
“Every dollar is not being spent wisely, but a lot of them are being spent effectively,” VanCronkhite said.
Looking for catalysts
Another factor creating twinges of anxiety in markets has been the recent upward pressure in short-term funding markets, especially as they reared up at the end of October.
While that eased last week, higher costs to transact overnight can be a warning sign of bigger troubles in the plumbing of the financial system – particularly if funding pressures persists beyond the typical month-end, quarter-end or year-end periods.
Some investors pointed to reduced liquidity in the financial system as a factor in bitcoin’s brief dip below the key $100,000 level last week, after its sharp drop from October’s record territory.
Guy LeBas, chief fixed-income strategist at Janney Montgomery Scott, said he thinks it’s a stretch to pin weakness in stocks and riskier assets on the Federal Reserve and recent “minor strains” in overnight funding markets.
“It has nothing to do with Fed policy in 9 out of 10 cases,” LeBas said. “Another way to summarize it [would be] investors who are long risk assets are complaining of reduced demand for risk assets.”
That said, “unsustainable behavior” by some investors in some corners of the market have been a worry to Allspring’s VanCronkhite, especially when looking beyond large-cap stocks to midcap and small-cap RUT sectors.
“They’re buying everything tied to themes when, very clearly, not everything is going to be a long-term win,” VanCronkhite said. He added that he hopes investors soon get into “the sorting-out phase,” where “garbage” investments are distinguished from those with staying power.
Meanwhile, even gold’s (GC00) eye-watering, more than 50% rally on the year might be in a consolidation phase, said Aakash Doshi, head of gold strategy at State Street Investment Management.
The precious metal was up about 0.3% so far in November, hovering around $4,000 an ounce on Friday. Doshi said he thinks gold likely ends the year around that same level, “give or take 5%.”
The week ahead likely won’t see the government shutdown come to an end, if betting markets end up being correct. Veterans Day on Tuesday will see the stock market remain open, but the bond market will be closed. There also will be plenty of Fed officials speaking during the week.
-Joy Wiltermuth
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
(END) Dow Jones Newswires
11-09-25 1200ET
Copyright (c) 2025 Dow Jones & Company, Inc.
Continue Reading
-

The bull market in stocks – and the ‘buy everything’ rally – now feel like an uphill battle
By Joy Wiltermuth
Tech and speculative assets are now in focus after the Nasdaq’s worst week since April
The “buy everything” rally since April now feels like an uphill battle.
It doesn’t feel like a “buy everything” market anymore.
Last week’s sharp pullback in tech stocks could easily turn into yet another buy-the-dip moment in the week ahead, like other times since April’s tariff-induced market plunge.
Bitcoin’s (BTCUSD) brush up against a new bear market could also prove fleeting, and the recent sharp selloff in other speculative corners of the market that began in late October might easily reverse.
Yet this moment seems a bit different – as though markets might be more fragile, and investors could be less inclined to simply stomp on the gas pedal at the first sign of any pullback.
“You aren’t going to get the timing right,” said Jim Baird, chief investment officer at Plante Moran Financial Advisors. “I’m not trying to guess what’s going to happen over the next week or month.” But the recent pain in areas that have “run a little hotter” is indicating that investors “are taking a little bit more cautious approach to the rally from April’s lows,” he said.
It’s been a pretty solid run for risk assets, Baird noted. But there have been cracks in credit markets, talk of more credit “cockroaches,” and other ominous indicators keeping investors on edge, in addition to a glaring “blind spot” in economic data during the ongoing, historic government shutdown.
“It isn’t as if everything is coming up roses,” Baird said of the rally since April. “Whether it’s economic, policy or geopolitical risks, there’s a lot for investors to absorb.”
Read: The shutdown is starting to ‘bite the economy,’ top Trump aide warns. The Senate is struggling to make a deal.
AI froth in focus
November typically ends up being a strong month for the stock market. But missed paychecks, nationwide flight cancellations and other ramifications of the government shutdown have paved the way for an unsteady start to the month.
The Nasdaq Composite COMP retreated 3% last week, logging its worst week since the early April tariff tumult, while the S&P 500 SPX shed 1.6% and the Dow Jones Industrial Average DJIA closed the week 1.2% lower, according to Dow Jones Market Data.
The pullback wasn’t terribly surprising. The S&P 500 remains up nearly 15% on the year despite higher tariffs, growing doubts about the job market and a fresh reading on the mood of U.S. consumers showing sentiment neared a record low in November.
Overall solid corporate earnings also didn’t prevent jitters around stock valuations and artificial-intelligence spending plans from returning, as well as concerns about when large tech companies might earn a return on those AI investments.
A look at the five top “hyperscalers” shows spending could hit $600 billion in two years at Amazon.com Inc. (AMZN), Microsoft Corp. (MSFT), Google parent Alphabet Inc. (GOOGL) (GOOG), Meta Platforms Inc. (META) and Oracle Corp. (ORCL), according to Thomas Shipp, head of equity research at LPL Financial.
Spending by five top “hyperscalers” in the AI race is projected to hit $600 billion in 2027
“I’m not worried about the AI capex spend,” said Bryant VanCronkhite, a senior equity portfolio manager at Allspring Global Investments. Despite “moments” when markets can pull back quickly, he said he’s more focused on the long-term opportunity.
“Every dollar is not being spent wisely, but a lot of them are being spent effectively,” VanCronkhite said.
Looking for catalysts
Another factor creating twinges of anxiety in markets has been the recent upward pressure in short-term funding markets, especially as they reared up at the end of October.
While that eased last week, higher costs to transact overnight can be a warning sign of bigger troubles in the plumbing of the financial system – particularly if funding pressures persists beyond the typical month-end, quarter-end or year-end periods.
Some investors pointed to reduced liquidity in the financial system as a factor in bitcoin’s brief dip below the key $100,000 level last week, after its sharp drop from October’s record territory.
Guy LeBas, chief fixed-income strategist at Janney Montgomery Scott, said he thinks it’s a stretch to pin weakness in stocks and riskier assets on the Federal Reserve and recent “minor strains” in overnight funding markets.
“It has nothing to do with Fed policy in 9 out of 10 cases,” LeBas said. “Another way to summarize it [would be] investors who are long risk assets are complaining of reduced demand for risk assets.”
That said, “unsustainable behavior” by some investors in some corners of the market have been a worry to Allspring’s VanCronkhite, especially when looking beyond large-cap stocks to midcap and small-cap RUT sectors.
“They’re buying everything tied to themes when, very clearly, not everything is going to be a long-term win,” VanCronkhite said. He added that he hopes investors soon get into “the sorting-out phase,” where “garbage” investments are distinguished from those with staying power.
Meanwhile, even gold’s (GC00) eye-watering, more than 50% rally on the year might be in a consolidation phase, said Aakash Doshi, head of gold strategy at State Street Investment Management.
The precious metal was up about 0.3% so far in November, hovering around $4,000 an ounce on Friday. Doshi said he thinks gold likely ends the year around that same level, “give or take 5%.”
The week ahead likely won’t see the government shutdown come to an end, if betting markets end up being correct. Veterans Day on Tuesday will see the stock market remain open, but the bond market will be closed. There also will be plenty of Fed officials speaking during the week.
-Joy Wiltermuth
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
(END) Dow Jones Newswires
11-09-25 1200ET
Copyright (c) 2025 Dow Jones & Company, Inc.
Continue Reading