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Asian stocks tracked Wall Street’s gains after dip buyers returned following a brief pullback in technology shares, and signs of a resilient US labor market lifted sentiment.

MSCI’s regional stock gauge rose 0.9%, with Hong Kong and Japan among the gainers. Contracts for the Nasdaq 100 index fell as much as 0.3% after Qualcomm Inc., the largest maker of smartphone processors, became the latest chipmaker to deliver an upbeat forecast and still leave investors underwhelmed. Its shares retreated 2% in late trading. Futures for the S&P 500 fell 0.2%.

LANZHOU — Chinese researchers have revealed the heart-protective effect of nicotinamide — a derivative of B vitamins — in exploring the mechanisms of related cardiotoxicity in tumor treatment, according to Lanzhou University.

Their study uncovered the mechanisms by which immune checkpoint inhibitors induce early cardiotoxicity, and developed a new, safe and effective approach to preventing and treating cardiotoxicity in patients receiving tumor immunotherapy, the university said.

Conducted by researchers at the Lanzhou University First Hospital, the study has been published in the Science China: Life Sciences journal.

Having the potential to result in death, cardiac immune-related adverse events associated with anti-programmed cell death protein 1 (PD-1), which is a type of immune checkpoint inhibitor, are becoming a concern. This study aimed to explore effective means of early warning and prevention, according to Bai Ming, a professor at the Lanzhou University First Hospital and the study”s leader.

The team first investigated the role of PD-1 in the early stages of cardiotoxicity and its underlying mechanisms by combining clinical data with experiments.

Then, the researchers conducted randomized controlled trials to verify the preventive effect of nicotinamide against early cardiotoxicity related to PD-1.

Their findings showed that nicotinamide demonstrates potential in preventing cardiotoxicity in patients receiving anti-PD-1 cancer treatment, according to Bai.

The clinical transformation of this research also confirmed that nicotinamide — a drug commonly used in clinical practice — is suitable for rapid transformation and application.

Nicotinamide therapy focuses on “early” cardiotoxicity, making it possible to prevent and treat cardiotoxicity. Therefore, this therapy highlights the concept of synergistic treatment that ensures anti-tumor efficacy while protecting heart functions, per the study.

“The findings of the study contribute to a better understanding of cardiac anti-PD-1 immune-related adverse events. They show that nicotinamide could be a promising preventive strategy in the early stages of cardiotoxicity, which is associated with the use of such checkpoint inhibitors in cancer treatment,” Bai said.

“Therefore, this study sheds new light on the well-considered safety issues in tumor treatment,” he added.

Nov 6 (Reuters) – Saudi Arabia, the world’s top oil exporter, has sharply reduced the prices of its crude for Asian buyers in December, responding to a well-supplied market as OPEC+ producers ramp up production.

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The December prices for other grades – Arab Medium and Arab Heavy – fell by $1.40 each to five cents and 10 cents a barrel, while that for Arab Extra Light dropped by $1.20 to $1.30 a barrel, the document said.

OPEC+ has raised output targets by around 2.9 million barrels per day, or about 2.7% of global supply, since April, but slowed the pace from October amid predictions of a looming oversupply.

Saudi Aramco determines its crude oil prices by incorporating feedback from customers and assessing monthly changes in the value of its oil, which are influenced by product prices and market yields.

As a matter of policy, Saudi Aramco officials do not comment on the kingdom’s monthly OSPs.

Below are Saudi prices for December in dollars per barrel.

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By Bill Peters

‘We wish there was a way to grow a baby into an adult without investment … but we do not believe this is how life or business works,’ company says

DoorDash’s autonomous delivery vehicle, Dot.

Shares of DoorDash Inc. tumbled in extended trading Wednesday, after the delivery platform said it plans to increase investments in its business next year and that its recent acquisition of Deliveroo would contribute less to profits in 2026 than once anticipated.

DoorDash’s stock (DASH) fell more than 9% after hours. However, the stock is still up around 42% so far this year.

The company said it expects to invest several hundred million dollars more in “new initiatives and platform development” in 2026 than it did last year, as it tries to expand internationally, compete with rivals’ overlapping services and roll out new technology to make orders faster and more precise.

“We wish there was a way to grow a baby into an adult without investment, or to see the baby grow into an adult overnight, but we do not believe this is how life or business works,” the company said in a statement announcing its third-quarter earnings.

DoorDash reported third-quarter revenue of $3.45 billion, up 27% from the same quarter last year and above FactSet analyst forecasts for $3.36 billion. The company earned 55 cents a share during the quarter, below estimates for 68 cents.

DoorDash’s gross order value, or the total dollar value of orders made on the platform, jumped 25% year over year to $25 billion in the third quarter. That was above expectations for $24.53 billion.

For the fourth quarter, DoorDash forecast $28.9 billion to $29.5 billion in gross order value. That outlook was above Wall Street’s forecast for $26.55 billion.

However, DoorDash said its purchase last month of Deliveroo – a London-based delivery company that operates in several nations in Europe, Asia and the Middle East – wouldn’t deliver as much to its adjusted profits as it initially thought.

DoorDash said that due to differences with Deliveroo’s accounting protocols, “we estimate that aligning our accounting treatment and definitions will reduce Deliveroo’s contribution to our reported adjusted Ebitda in 2026 by approximately $32-40 million compared to what weestimate it would have reported prior to our acquisition.” (Ebitda stands for earnings before interest, taxes, depreciation and amortization.)

DoorDash, known for its delivery and takeout services for restaurants, has over recent years been trying to deliver more items from grocery stores and other retailers in an effort to become a bigger part of local economies.

In September, the company announced the launch of new features, including a new autonomous delivery robot, called Dot, and services like restaurant reservations. Ethan Feller, a stock strategist at Zacks Investment Research, said that the move showed how DoorDash had helped turned online delivery services into an expectation. He said the expansion risked overlap with other companies – and a “commoditization” of those services – but noted that they could be discarded if they didn’t work.

In September, DoorDash and supermarket chain Kroger Co. (KR) said they would expand their partnership to deliver more groceries to shoppers’ homes. Some analysts said the announcement marked a bigger threat to grocery-delivery platform Instacart (CART).

-Bill Peters

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  11-05-25 2028ET
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