Enrichment of EMT in CRC
Analysis of gene expression data from the GSE39582 and TCGA datasets revealed that GSEA results indicated significant enrichment of EMT in CRC, suggesting that EMT might play a critical role in the initiation and…

Analysis of gene expression data from the GSE39582 and TCGA datasets revealed that GSEA results indicated significant enrichment of EMT in CRC, suggesting that EMT might play a critical role in the initiation and…
A study published in the American Journal of Psychiatry looks at doxycycline use in adolescent psychiatric…

Awami Muslim League chief and former Interior Minister Sheikh Rashid Ahmed was stopped from travelling abroad on Wednesday despite possessing a court order allowing him to do so. According to details, Sheikh Rashid was scheduled…

The pharmaceutical landscape in Pakistan is changing fast. From capacity constraints and evolving regulations to rising demand for traceability, companies are rethinking how medicines are sourced, manufactured and delivered. This isn’t only about cutting costs or boosting efficiency, it’s about building resilience, agility and unwavering quality in the face of supply chain disruptions.
Join us at Pharma Asia International Conference 2025 to uncover the latest insights and shape strategies that strengthen cold chain logistics. Backed by integrated solutions and hands-on expertise, we’re dedicated to supporting the seamless transport of life-saving medicines worldwide, always with the highest standards of care.

Weaving Back to Common Grounds by otc – Observant Thick Conversation (Rahel grote Lambers, Alexander Klaubert, Francis Kussatz & Julia Lübbecke) marks the final stage of the two-year project Have We Passed Peak Collective, developed in…

The new Cayenne Electric benefits greatly from the sports car manufacturer’s experience in Formula E. Some of the technology in the fully electric SUV originate from the Porsche 99X Electric and sets standards in terms of efficiency and performance. Among other things, both cars use direct oil cooling of the electric motor and have a recuperation capacity of up to 600 kW. “Formula E is our development lab for the electromobility of tomorrow. This is where we gain valuable insights for our road-going sports cars,” says Dr Michael Steiner, Member of the Board of Management for Research and Development. “The new Cayenne Electric shows how quickly such a technology transfer takes place at Porsche and how relevant our commitment to the electric racing series is to series production.”
“In Formula E, efficiency is the difference between victory and defeat. This principle also shapes the Cayenne Electric,” continues Florian Modlinger, Director Factory Motorsport Formula E and team principal of the factory Porsche Formula E team. “Efficiency is not only the focus in terms of the vehicles themselves; the agile working methods proven in racing can also help to shorten development times and accelerate the transfer of technology.”
The heads of motorsport and series development sit close together in Weissach. This promotes the exchange of knowledge between projects. What is tested on the racetrack inspires what happens in series production – and vice versa: the racing car also sometimes learns from the road car. Charging is probably the most striking area for technology transfer; the sockets and plugs of the 99X racing car and the electric Porsche sports cars are completely alike. The underlying CCS (Combined Charging System) technology is not only the standard on the road but also in Formula E.
A prime example of technology transfer from motorsport to series production is direct oil cooling. Here, all current-carrying components of the electric drive system are cooled directly by a specially developed liquid, which significantly improves efficiency and sustained, continuous performance. Porsche has been using this innovative technology in Formula E since the start of the project – with an increasing degree of integration. From 2023, the GT4 e-Performance test vehicle also trialled direct oil cooling on the racetrack. Now it is entering series production, used in the rear motor of the flagship Cayenne Electric.
While in conventional electric motors the coolant flows through a jacket outside the stator, with direct cooling the coolant flows directly along the copper conductors via stator grooves. This allows the heat to be dissipated directly where it is generated. To achieve the same efficiency and performance values, a motor cooled by a water jacket would also have to be about 1.5 times larger. Thanks to direct cooling, it was possible to choose a design for the Cayenne that enables an efficiency of up to 98 per cent. The competition variant in the 99X achieves an even higher value.
Recuperation significantly increases the efficiency of both vehicles. Energy recovered during braking is fed into the battery and can then be used again for propulsion. More recuperation therefore allows for longer ranges and ultimately smaller batteries – the key to greater performance for both sports and racing cars. In Formula E, the amount of energy available is deliberately limited: the 99X Electric is allowed to start a race with a maximum of 38.5 kWh of usable energy in the battery. If it recovers more energy during braking than its competitors, it then has more energy available to push for the finish line.
“The challenge of recuperation is highly complex,” says Modlinger. “When braking, we want to recover as much energy as possible while reducing speed as quickly as possible. Depending on brake pressure, we also engage the front wheel brakes. The car’s balance should match the driver’s preferences – it contributes to their confidence in the car and, as a consequence, to performance. On the road, it’s also a matter of driving safety. To bring all this together, a variety of software functions are active during braking — a huge area for potential knowledge transfer.”
Up to 600 kW of recuperation power is possible in the Cayenne, depending on speed, temperature and the charge state of the battery. This means that the SUV achieves the same peak value as the 99X Electric. In the Cayenne, too, high-performance recuperation remains active during dynamic driving. In everyday driving situations, about 97 per cent of all braking manoeuvres are purely electric, without the need for mechanical disc brakes to assist. Depending on the driving manoeuvre, recuperation can continue until the vehicle comes to a standstill. It is only when deceleration exceeds the recuperation limit that the friction brakes on the front and rear axles intervene imperceptibly to the driver – a perfect interplay of efficiency and driving comfort, inspired by motorsport.
Since last season, Formula E has introduced fast charging pit stops known as Pit Boosts. A 30-second charge with a charging capacity of 600 kW provides the battery of the 99X Electric with a 10 per cent energy boost. The Cayenne Electric is also designed for fast pit stops; it takes less than 16 minutes to charge its battery from a 10 to 80 per cent state of charge (SoC).
It’s not just in races that things get heated. Temperatures fluctuate greatly in everyday driving too. Porsche’s philosophy is that high charging performance must be achieved even under adverse conditions across a wide SoC range. The DC charging power of the Cayenne is up to 400 kW. Fast charging is possible from a battery temperature of 15 degrees Celsius. Up to an SoC of about 55 per cent, the charging power is more than 350 kW – so the fast-charging processes are very robust. Within 10 minutes of charging at a suitable station, more than 300 km of range can be added.
Formula E is also a test laboratory and showcase for fast charging: “The drivers push the cars to the limit – sometimes in scorching-hot cities, such as Jakarta. When we come into the pits to charge, the system temperatures are often very high,” says Modlinger. “At the same time, we want to keep the cooling requirements on the racing car as low as possible, because cooling consumes energy and, depending on the hardware, increases weight. So, during Pit Boost pit stops, we demonstrate an energy supply with enormous charging power under extreme conditions.”
In Formula E, Porsche invests its available budget primarily in those vehicle components that are also relevant for road use. According to the regulations, these components are located beneath the bodywork. Modlinger: “Our technical challenges are not visible from the outside. But they are considerable and, in many areas, they are similar to those we face in our electric road-going sports cars.”
“Enter Electric!“
The Volkswagen Group invites you to find out much more about electromobility with a cross-brand communication campaign. You can find more information about electromobility at Porsche on this Newsroom microsite.

A new leak from the long-trusted tipster Ice Universe has materialized with photos and a brief video snippet of the alleged Galaxy S26 Ultra side by side with Samsung’s own Galaxy S25 Ultra and Apple’s upcoming iPhone 17 Pro Max, giving the…

Profits at Marks & Spencer have more than halved after the retailer suffered a damaging cyber-attack, which is still affecting its struggling clothing and homeware business.
The retailer said underlying profits more than halved to £184.1m in the six months to 27 September from £413.1m a year before, after it had to halt online orders of clothing and homewares for more than six weeks.
The company’s clothing and homeware sales slumped 16.4% in the half year. The retailer said the division had been “slower” to recover from the hack than its food arm.
M&S said that sales of fashion in stores had been “impacted by reduced availability and fewer visits linked to the absence of click and collect”, and warehouse systems were now restored so “both our website and stores are improving availability, and trading is recovering”.
Food sales rose by a slightly better than expected 7.8% in the half year and the retailer said it was “largely recovered” from the effects of the attack. Group sales rose 22% to £7.96bn.
“We are confident we will be recovered and back on track by the financial year end [in March],” it said in a statement.
M&S said profits had been helped by a quick recovery of £100m in cyber insurance but hit by £50m on a new packaging recycling levy and additional insurance costs. It is now looking to make £600m in cost savings this year as it battles to keep annual profits steady – £100m more than previously planned.
Despite the cost-cutting, it opened six stores in the six months to the end of September and plans 12 more by March.
Stuart Machin, the chief executive of M&S, said: “In the second half, we expect profit to be at least in line with last year. This should give us a springboard into the new financial year and set M&S up for further growth.
“The retail sector is facing significant headwinds – in the first half, cost increases from new taxes were over £50m – but there is much within our control and accelerating our cost reduction programme will help to mitigate this.
“Our plan to reshape M&S for long-term sustainable growth is unchanged, our ambitions are undimmed, and our determination to knuckle down and deliver is stronger than ever.”
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Last week the rival Next raised hopes that UK consumers were still willing to spend despite pressures on household budgets, as it revealed sales and profit growth “materially above” expectations.
M&S said in May that it expected to take an estimated £300m hit to profits this year from the damaging cyber-attack. However, it said it expected to halve that financial impact of the attack to about £150m through insurance, cost reductions and other actions.
The attack on M&S’s IT systems over the Easter weekend forced the retailer to stop orders via its website, through which it sells fashion, homeware and gifts, for more than six weeks.
Deliveries of food and fashion into stores and some deliveries to its online food partner, Ocado, were also been disrupted.

The multi-year project, called Bridging Worlds, is co-led by researchers from both universities and is funded by the Kusuma Trust.
Using hands-on activities, such as wildlife surveys and photography, participants from Plymouth schools are…