A groundbreaking study published in Nature’s Communications Biology sheds new light on the relationship between bats and dangerous viruses. Led by researchers at the University of Oklahoma, the study shows that contrary to…
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Smartphones match traditional methods in monitoring patients with muscular dystrophy
Stanford Medicine researchers found that a smartphone could monitor patients with two types of muscular dystrophy as well as traditional methods and diagnose conditions more accurately — at no cost.
Because researchers have made…
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Pakistan show women’s coach the exit door following team’s finish at the last spot in the World Cup
The Pakistan Cricket Board (PCB) will not renew the contract of women’s head coach Mohammad Waseem after the side finished at the bottom of the points table in the recently concluded World Cup in India and Sri Lanka. The Fatima Sana-led side…
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Hijacking cellular machinery within cancer cells to promote antitumor immunity
Investigators from Mass General Brigham have developed a way to promote antitumor immunity by hijacking cellular machinery within cancer cells. The study demonstrated that inducing cancer cells to produce an immune-activating molecule led to reduced tumor growth in preclinical models. Results are published in PNAS.
“Tumor cells comprise a significant proportion of the tumor microenvironment but are often under-utilized for immunotherapy,” said corresponding author Natalie Artzi, PhD, a researcher in the Mass General Brigham Department of Medicine. “These findings highlight how tumor cells can be used to actively contribute to their own elimination.”
The presence of double-stranded DNA (dsDNA) in a cell’s cytoplasm activates innate immune sensors that set off defense mechanisms against potential infections or cellular damage. One such sensor known as cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and produces cyclic GMP-AMP (cGAMP), which triggers the stimulator of interferon genes (STING) pathway and leads to inflammatory immune responses. Furthermore, cGAMP can be transported out of the cell to activate neighbouring cells. While cancer cells can have high levels of cytosolic dsDNA, they often silence the cGAS-STING pathway – preventing their own activation and of bystander immune cells within the tumor microenvironment.
The research team exploited this innate mechanism within cancer cells to increase cGAMP production and thereby boost antitumor immunity. They found that cultured mouse melanoma cells upregulated cGAMP production when treated with dsDNA and lipid nanoparticles (LNPs) carrying mRNA coding for cGAS. Immune cells showed signs of activation in response to elevated extracellular cGAMP levels produced by cancer cells. Similarly, treatment with cGAS LNPs activated surrounding immune cells, slowed tumor growth and improved overall survival in mouse models of aggressive melanoma. Combining this treatment with immune checkpoint blockade therapy further improved outcomes.
The authors suggest that this strategy could find future applications beyond cancer therapies, including in vaccines.
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Starbucks to Sell 60% of Its China Business to a Private Equity Firm – The New York Times
- Starbucks to Sell 60% of Its China Business to a Private Equity Firm The New York Times
- Starbucks and Boyu Announce Joint Venture for the Next Chapter of Growth in China Starbucks Coffee
- Factbox-Who’s selling? Starbucks and other US companies trimming China exposure By Reuters Investing.com
- Starbucks Joins Long List Of US Firms Selling China Stakes Finimize
- Starbucks cedes China control to Boyu Capital Yahoo Finance
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NIH grant supports research on how the immune system responds to serious eye infections
New research that sheds light on how the immune system responds to serious eye infections is underway at Wayne State University, supported by a $2.3 million federal grant from the National Eye Institute of the National Institutes of…
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Dengue continues to haunt people as number of cases reaches 4,836 – Dawn
- Dengue continues to haunt people as number of cases reaches 4,836 Dawn
- A worker sprays fumigation vapour to stem the spread of dengue virus in Peshawar Reuters Connect
- Dengue cases surge in Khyber Pakhtunkhwa Aaj English TV
- Public representatives…
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Shutdown Nears Its End — But Economic Damage Is Mounting, Goldman Says
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The U.S. government shutdown has dragged into its 33rd day, and while a resolution may soon be approaching, economists warn the economic fallout is already underway.
In a note to clients on Monday, Goldman Sachs economist Alec Phillips said the standoff in Washington is likely to cost the U.S. economy more than a full percentage point of growth in the final quarter of 2025, shaving GDP growth to just 1.0%.
That’s a significant downgrade. Goldman had previously expected a stronger finish to the year, but now believes the shutdown will result in postponed federal spending, delayed hiring, and reduced investment.
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If current odds are any guide, the shutdown could stretch further still.
Prediction markets tracked by CFTC-regulated betting platform Kalshi peg the median expected duration at 45.9 days, or until Nov. 15.
As of now, there’s an implied 75% chance it lasts over 40 days, and a 35% chance it extends beyond 50.
The standoff is shaping up to become the longest government shutdown in U.S. history, surpassing the 35-day shutdown in 2018-2019.
Yet pressure is mounting. Missed pay for air traffic controllers and TSA screeners on Oct. 28, with another due Nov. 10, threatens a replay of the 2019 shutdown, when airport delays forced a last-minute compromise.
Meanwhile, SNAP food benefits, normally issued the first week of each month, are at risk—though a recent court ruling may allow for partial disbursement using contingency funds.
Unlike previous shutdowns that targeted specific agencies, this one involves a full lapse in congressional appropriations, making it broader in scope and impact.
“This shutdown will have the greatest economic effect on record,” Goldman said in the note. “A longer duration could spill over into private-sector activity, delaying investments and stalling consumption.”
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The immediate damage is expected to come from federal employee furloughs and delayed government purchases.
If the shutdown runs six weeks, federal spending pushed into first-quarter 2026 could slightly boost growth by 1.3 percentage points in that quarter, according to Goldman’s models.
Goldman Sachs sees growing signs the shutdown may soon end. The start of ACA enrollment on November 1 has intensified focus on health care subsidies, while the November 4 elections and the upcoming congressional recess could shift political incentives. Public-sector unions, including the AFGE, are now calling for a resolution, adding pressure on Democrats and Republicans to reach a deal.
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Lily Allen Does Revenge Dressing at the 2025 CFDA Awards
If you’re anything like us, you’ve had Lily Allen’s new album West End Girl on repeat this month. Raw and poignant, the British singer has released one of the best records of the year. Through her signature cheeky writing and infectious…
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Injectable polio vaccine debuted in Punjab – Dawn
- Injectable polio vaccine debuted in Punjab Dawn
- fIPV drive to begin tomorrow Business Recorder
- Punjab launches injectable polio vaccine campaign for children Minute Mirror
- Punjab launches fiPV polio vaccine drive in 122 Lahore union councils
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