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  • What the key witnesses at Sean 'Diddy' Combs' sex trafficking trial told the jury – San Francisco Chronicle

    1. What the key witnesses at Sean ‘Diddy’ Combs’ sex trafficking trial told the jury  San Francisco Chronicle
    2. Diddy jury to keep deliberating after deadlocking on most serious charge  BBC
    3. June 30, 2025 – Jury begins deliberations in the Sean ‘Diddy’ Combs trial  CNN
    4. Sean ‘Diddy’ Combs trial updates: Judge tells jury to keep deliberating after partial verdict  ABC News – Breaking News, Latest News and Videos
    5. Jury reaches partial verdict in Sean ‘Diddy’ Combs sex-trafficking trial  The Express Tribune

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  • Cardiac MRI Study Affirms Link Between Air Pollution Exposure and Increased Diffuse Myocardial Fibrosis

    Cardiac MRI Study Affirms Link Between Air Pollution Exposure and Increased Diffuse Myocardial Fibrosis

    Air pollution exposure can be a key contributing factor to increasingly diffuse myocardial fibrosis, according to cardiac magnetic resonance imaging (MRI) findings from a new study.

    For the retrospective study, recently published in Radiology, researchers reviewed cardiac MRI data for 694 patients (mean age of 47), including 493 people with dilated cardiomyopathy (DCM) and 201 people with normal cardiac MRI.

    In a multivariable analysis, the study authors found that for patients with DCM, each 1 µg/m3 increase in one-year mean exposure to ambient fine particulate matter with 2.5-µm or smaller aerodynamic diameter (PM2.5) corresponded to a 30 percent higher native T1 z score.

    In a new cardiac MRI study, researchers noted that patients with higher long-term exposure to fine particulate air pollution demonstrated a higher extent of myocardial fibrosis as evidenced by the cardiac T1 MRI mapping images above. (Images courtesy of Radiology.)

    The researchers also noted that each 1 µg/m3 increase in one-year mean exposure to PM2.5 was associated with a 27 percent higher native T1 z score in people with normal cardiac MRI findings.

    “In line with other studies, our results indicate that adverse effects of fine particulate air pollution on the heart are observed at exposures below current air quality guidelines, reinforcing that there are no safe exposure limits. Our results bolster evidence that air pollution is a modifiable risk factor for cardiovascular disease,” noted study co-author Kate Hanneman, M.D., MPH, FRCPC, an associate professor and vice chair of research with the Department of Medical Imaging at the University of Toronto, and colleagues.

    Late gadolinium enhancement (LGE) was 25 percent more likely for each 1 µg/m3 increase in one-year mean exposure to PM2. in patients with DCM, according to the study authors.

    The researchers also found that the association between ambient PM2.5 exposure and native T1 z scores was particularly prevalent among women (β coefficient of 49 percent), people with hypertension (β coefficient of 48 percent) and smokers (β coefficient of 43 percent).

    “Myocardial fibrosis is irreversible; therefore, it is imperative to implement measures to reduce exposure to long-term air pollution, especially in the most vulnerable patients,” emphasized Hanneman and colleagues.

    Three Key Takeaways

    1. Air pollution correlates with myocardial fibrosis. Each 1 µg/m³ increase in PM2.5 exposure over one year was linked to a 30 percent higher native T1 z score in patients with dilated cardiomyopathy (DCM) and a 27 percent increase in individuals with normal cardiac MRI findings, indicating diffuse myocardial fibrosis.
    2. Risk is heightened in vulnerable subgroups. Stronger associations between PM2.5 exposure and elevated native T1 z scores were observed in women (49 percent), individuals with hypertension (48 percent), and smokers (43 percent).
    3. Pollution exposure linked to structural heart changes. Among patients with DCM, each 1 µg/m³ increase in PM2.5 exposure was associated with a 25 percent higher likelihood of late gadolinium enhancement (LGE), further indicating structural myocardial injury.

    In an accompanying editorial, Davis M. Vigneault, M.D., D.Phil, said the study builds upon previous biochemical and epidemiological studies demonstrating elevated cardiovascular risks with air pollution exposure.

    “… This study provides new and compelling evidence for a potential pathologic mechanism by which fine particulate matter pollution increases cardiovascular risk, tying together biochemical evidence implicating PM2.5 in the induction of myocardial fibrosis with epidemiologic evidence associating PM2.5 with morphologic changes and increased cardiovascular morbidity and mortality,” wrote Dr. Vigneault, who is affiliated with the Department of Radiology at the Stanford University School of Medicine in Stanford, Ca.

    (Editor’s note: For related content, see “Could Cardiac MRI Improve Risk Stratification in Patients with Dilated Cardiomyopathy?,” “Stress Cardiovascular MRI: What a New Meta-Analysis Reveals” and “Multimodal AI with CCTA and MRI Data Shows Promise in Predicting MACE in Patients with Obstructive CAD.”)

    Beyond the inherent limitations of a single-center retrospective study, the study authors conceded possible differences with respect to the timing of exposure to PM2.5, and potentially unknown confounding factors that may have affected the results. The researchers acknowledged that indoor PM2.5, ozone and nitrogen dioxide exposures were not assessed. They also noted that the COVID-19 pandemic occurred within the study period.

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  • Squid Game season three breaks Netflix viewership record | Squid Game

    Squid Game season three breaks Netflix viewership record | Squid Game

    The third and final season of hit Korean series Squid Game has broken records to achieve the biggest ever TV launch for Netflix.

    Over its first three days, there have been over 60.1m views, a new high for the streamer with over 368.4m hours viewed. The second season launched with 68m views but over a four-day period last December.

    It has already become the ninth biggest non-English language season ever with the first and second seasons occupying the top two slots.

    Reviews have been mixed to positive with the Guardian’s Rebecca Nicholson calling it “nowhere near as pointed as it was” in previous seasons.

    While this has been called the final season, David Fincher has been rumoured to be developing an English language remake for the streamer. The director has worked with Netflix before on political drama series House of Cards, film industry biopic Mank and Michael Fassbender action thriller The Killer. Earlier this year, it was announced that he would work with them once again to direct a sequel to Once Upon a Time in Hollywood based on a script by Quentin Tarantino.

    The streamer has already found success with competition spin-off Squid Game: The Challenge with a second season on the way.

    When asked about future Squid Game projects, series creator Hwang Dong-hyuk told Variety that he hadn’t heard anything official yet about a remake.

    “If they wanted to do a following season, then I think it’s obvious I would have to participate and lead,” he said. “But if it’s the US version that they’re making, I think sharing of ideas would be enough. I have no intention of being completely hands-on in a project like that. Having said that, if Netflix asks and if I feel like my contribution is needed, then as long as it’s not something that would interfere with whatever I’m working on at that time, I would be happy to provide what they need from me.”

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  • Wall Street Revives Big-to-Small Stock Rotation: Markets Wrap

    Wall Street Revives Big-to-Small Stock Rotation: Markets Wrap

    (Bloomberg) — Wall Street traders drove a rotation out of the tech megacaps that had powered stocks from the brink of a bear market. Bond yields rose as an increase in job openings dimmed the outlook for Federal Reserve rate cuts. The dollar remained at its lowest since 2022.

    While the S&P 500 barely budged after notching all-time highs, a violent rotation took place at the start of July, with money chasing losers at the expense of recent winners. Momentum was unwinding at a pace not seen in over two years, and the small-cap Russell 2000 index beat the tech-heavy Nasdaq 100 by the most since April.

    Subscribe to the Stock Movers Podcast on Apple, Spotify and other Podcast Platforms.   

    “If you’re long recent winners and are feeling the pain today, we would not be making any dramatic portfolio shifts just yet,” said Bespoke Investment Group strategists. “It could be the start of a longer-term shift that develops, but a one-day move is simply too soon to tell.”

    Short-dated Treasuries, which are more sensitive to imminent Fed moves, underperformed longer maturities.

    US job openings hit the highest since November, largely fueled by leisure and hospitality, and layoffs declined. Fed policymakers have consistently characterized labor-market conditions as strong in recent weeks.

    “As long as the labor market remains solid, the US economy can continue to chug ahead, while helping reduce the risk of stagflation” said Bret Kenwell at eToro. “It would also buy the Fed more breathing room when it comes to interest rates.”

    Speaking Tuesday during a panel in Portugal, Fed Chair Jerome Powell repeated that the central bank probably would have cut rates further this year absent Trump’s expanded use of tariffs. Still, when asked if July was too soon for a rate cut, Powell didn’t rule out the possibility.

    The government’s June employment report, due Thursday, is expected to show a slowdown in nonfarm payroll growth and an uptick in the unemployment rate.

    “Federal Reserve interest-rate policy is likely on hold for now,” said Josh Hirt at Vanguard. “If the labor market remains on the trajectory we expect, the Fed can afford to be patient. We anticipate the Fed will be able to make two more rate cuts later this year in this environment.”

    Separate data Tuesday showed US factory activity contracted in June for a fourth consecutive month as orders and employment shrank at a faster pace, extending the malaise in manufacturing.

    “While the hit to manufacturing activity from tariffs so far appears to have been limited, the further small rise in the prices paid index last month adds to evidence that firms are facing higher costs as a result,” said Thomas Ryan at Capital Economics.

    Meantime, Trump said he is not considering delaying his July 9 deadline for higher tariffs to resume and renewed his threat to cut off talks and impose duty rates on several nations, including Japan. And his $3.3 trillion tax and spending cut bill passed the Senate.

    Corporate Highlights:

    • Sweeping tax legislation passed by the Senate would make it cheaper for semiconductor manufacturers to build plants in the US, delivering a win to chipmakers and boosting US efforts to expand the industry domestically.
    • Tesla Inc. sank as Trump threatened to withdraw subsidies from Elon Musk’s companies and examine the billionaire’s immigration status.
    • Boeing Co. said Stephen Parker will oversee the defense, space and security unit on a permanent basis, as Chief Executive Officer Kelly Ortberg molds his top leadership team, including the appointment of a new chief financial officer.
    • Ford Motor Co.’s electric vehicle sales plunged 31.4% in the second quarter after the automaker ordered dealers not to sell its battery-powered Mustang Mach-e model due to a safety flaw that could lock occupants in the car.
    • UnitedHealth Group Inc. and Memorial Sloan Kettering Cancer Center resolved a contract dispute that threatened to interrupt treatment for thousands of cancer patients in the New York City area.
    • AMC Entertainment Holdings Inc. said it reached an agreement with a majority of bondholders to end litigation that resulted from the movie theater chain’s debt restructuring last year.
    • Wolfspeed Inc., a chipmaker caught in President Donald Trump’s push to reshape Biden-era tech subsidies, filed bankruptcy to enact a creditor-backed plan to slash $4.6 billion in debt.
    • Macau’s monthly gaming revenue rose 19% in June, exceeding analyst expectations as visitors poured in to the world’s biggest gambling hub for Cantonese pop concerts and other entertainment offerings.

    Some of the main moves in markets:

    Stocks

    • The S&P 500 fell 0.1% as of 4 p.m. New York time
    • The Nasdaq 100 fell 0.9%
    • The Dow Jones Industrial Average rose 0.9%
    • The MSCI World Index fell 0.1%
    • Bloomberg Magnificent 7 Total Return Index fell 1.5%
    • The Russell 2000 Index rose 0.9%

    Currencies

    • The Bloomberg Dollar Spot Index was little changed
    • The euro was little changed at $1.1793
    • The British pound was little changed at $1.3741
    • The Japanese yen rose 0.2% to 143.75 per dollar

    Cryptocurrencies

    • Bitcoin fell 2.1% to $105,393.95
    • Ether fell 4% to $2,404.6

    Bonds

    • The yield on 10-year Treasuries advanced two basis points to 4.25%
    • Germany’s 10-year yield declined three basis points to 2.57%
    • Britain’s 10-year yield declined three basis points to 4.45%

    Commodities

    • West Texas Intermediate crude rose 0.9% to $65.70 a barrel
    • Spot gold rose 1% to $3,337.42 an ounce

    ©2025 Bloomberg L.P.

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  • New study finds U.S. preschoolers widely exposed to potentially harmful chemicals-Xinhua

    LOS ANGELES, July 1 (Xinhua) — Children aged two to four in the United States are widely exposed to a broad range of potentially harmful chemicals, many of which are not currently tracked by national health surveys, according to a new study published Tuesday.

    The study, published in the journal Environmental Science & Technology, was conducted by multiple institutions across the United States and supported by the U.S. National Institutes of Health.

    Researchers analyzed urine samples from 201 children aged two to four in California, Georgia, New York and Washington. They tested for 111 chemicals and detected 96 in at least five children, 48 in more than half, and 34 in over 90 percent of the children tested.

    Many of the chemicals identified are not routinely monitored and may pose health risks, the study warned.

    The detected substances include phthalates and their alternatives, parabens, bisphenols, benzophenones, pesticides, organophosphate esters, polycyclic aromatic hydrocarbons (PAHs) and bactericides. These chemicals are commonly found in household products, personal care items, food packaging, furniture and air pollution.

    Children are exposed to these chemicals through everyday activities such as eating, drinking, playing, and breathing indoor and outdoor air.

    “Our study shows that childhood exposure to potentially harmful chemicals is widespread. This is alarming because we know early childhood is a critical window for brain and body development,” said Deborah H. Bennett, lead author and professor in the Department of Public Health Sciences at the University of California, Davis (UC Davis).

    “Many of these chemicals are known or suspected to interfere with hormones, brain development and immune function,” she noted.

    The researchers stressed the need for further studies to better understand the long-term health impacts of these exposures.

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  • Carnival Corporation & plc Announces Pricing of €1.0 Billion 4.125% Senior Unsecured Notes Offering

    Proceeds from the offering of senior unsecured notes to be used to repay borrowings under the senior secured term loan facilities

    MIAMI, July 1, 2025 /PRNewswire/ — Carnival Corporation & plc (NYSE/LSE: CCL; NYSE: CUK) today announced that Carnival plc (the “Company”) priced its private offering (the “Notes Offering”) of €1.0 billion aggregate principal amount of 4.125% senior unsecured notes due 2031 (the “Notes”). The Company expects to use the proceeds from the Notes Offering to fully repay the borrowings under Carnival Corporation’s first-priority senior secured term loan facility maturing in 2027 (the “2027 Term Loan Facility”) and to repay a portion of the borrowings under Carnival Corporation’s first-priority senior secured term loan facility maturing in 2028. In conjunction with the Company’s prepayment of $450.0 million on June 27, 2025 towards the 2027 Term Loan Facility, this transaction builds on its continuing efforts to deleverage, reduce interest expense, simplify its capital structure and manage its maturity profile.

    The Notes Offering is expected to close on July 7, 2025, subject to customary closing conditions. The indenture that will govern the Notes will have investment grade-style covenants.

    The Notes will pay interest annually on July 15 of each year, beginning on July 15, 2026, at a rate of 4.125% per year. The Notes will be unsecured and will mature on July 15, 2031. The Notes will be fully and unconditionally guaranteed on an unsecured basis, jointly and severally, by Carnival Corporation and initially certain of the Company’s and Carnival Corporation’s subsidiaries that also guarantee our first-priority secured indebtedness, certain of our other unsecured notes and our convertible notes.

    The Notes are being offered only to persons reasonably believed to be qualified institutional buyers in reliance on Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”), and outside the United States, only to non-U.S. investors pursuant to Regulation S under the Securities Act.

    The Notes will not be registered under the Securities Act or any state securities laws and may not be offered or sold in the United States absent registration or an applicable exemption from the registration requirements of the Securities Act and applicable state laws.

    This press release shall not constitute an offer to sell or the solicitation of an offer to purchase the Notes or any other securities and shall not constitute an offer, solicitation or sale in any state or jurisdiction in which such offering, solicitation or sale would be unlawful.

    About Carnival Corporation & plc

    Carnival Corporation & plc is the largest global cruise company, and among the largest leisure travel companies, with a portfolio of world-class cruise lines – AIDA Cruises, Carnival Cruise Line, Costa Cruises, Cunard, Holland America Line, P&O Cruises, Princess Cruises and Seabourn.

    Cautionary Note Concerning Forward-Looking Statements

    Certain statements in this press release constitute forward-looking statements under the Private Securities Litigation Reform Act of 1995. These statements relate to, among other things, the financing transactions described herein, future results, operations, outlooks, plans, goals, reputation, cash flows and liquidity and other events which have not yet occurred. Forward-looking statements reflect management’s current expectations and are subject to risks, uncertainties and other factors that could cause our actual results, performance or achievements to differ materially from the future results, performance or achievements expressed or implied in those forward-looking statements. Factors that could affect our results include, among others, those discussed under the caption “Risk Factors” in our most recent annual report on Form 10-K, as well as our other filings with the Securities and Exchange Commission (the “SEC”), copies of which may be obtained by visiting the  Investor Relations page of our website at www.carnivalcorp.com/investors/ or the SEC’s website at www.sec.gov. Undue reliance should not be placed on the forward-looking statements in this release, which are based on information available to us on the date hereof. We undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise.

    SOURCE Carnival Corporation & plc

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  • MIT Open Learning bootcamp supports effort to bring invention for long-term fentanyl recovery to market | MIT News

    MIT Open Learning bootcamp supports effort to bring invention for long-term fentanyl recovery to market | MIT News

    Evan Kharasch, professor of anesthesiology and vice chair for innovation at Duke University, has developed two approaches that may aid in fentanyl addiction recovery. After attending MIT’s Substance Use Disorders (SUD) Ventures Bootcamp, he’s committed to bringing them to market.

    Illicit fentanyl addiction is still a national emergency in the United States, fueled by years of opioid misuse. As opioid prescriptions fell by 50 percent over 15 years, many turned to street drugs. Among those drugs, fentanyl stands out for its potency — just 2 milligrams can be fatal — and its low production cost. Often mixed with other drugs, it contributed to a large portion of over 80,000 overdose deaths in 2024. It has been particularly challenging to treat with currently available medications for opioid use disorder.  

    ​​As an anesthesiologist, Kharasch is highly experienced with opioids, including methadone, one of only three drugs approved in the United States for treating opioid use disorder. Methadone is a key option for managing fentanyl use. It’s employed to transition patients off fentanyl and to support ongoing maintenance, but access is limited, with only 20 percent of eligible patients receiving it. Initiating and adjusting methadone treatment can take weeks due to its clinical characteristics, often causing withdrawal and requiring longer hospital stays. Maintenance demands daily visits to one of just over 2,000 clinics, disrupting work or study and leading most patients to drop out after a few months.

    To tackle these challenges, Kharasch developed two novel methadone formulations: one for faster absorption to cut initiation time from weeks to days — or even hours — and one to slow elimination, thereby potentially requiring only weekly, rather than daily, dosing. As a clinician, scientist, and entrepreneur, he sees the science as demanding, but bringing these treatments to patients presents an even greater challenge. Kharasch learned about the SUD Ventures Bootcamp, part of MIT Open Learning, as a recipient of research funding from the National Institute on Drug Abuse (NIDA). He decided to apply to bridge the gap in his expertise and was selected to attend as a fellow.

    Each year, the SUD Ventures Bootcamp unites innovators — including scientists, entrepreneurs, and medical professionals — to develop bold, cross-disciplinary solutions to substance use disorders. Through online learning and an intensive one-week in-person bootcamp, teams tackle challenges in different “high priority” areas. Guided by experts in science, entrepreneurship, and policy, they build and pitch ventures aimed at real-world impact. Beyond the multidisciplinary curriculum, the program connects people deeply committed to this space and equipped to drive progress.

    Throughout the program, Kharasch’s concepts were validated by the invited industry experts, who highlighted the potential impact of a longer-acting methadone formulation, particularly in correctional settings. Encouragement from MIT professors, coaches, and peers energized Kharasch to fully pursue commercialization. He has already begun securing intellectual property rights, validating the regulatory pathway through the U.S Food and Drug Administration, and gathering market and patient feedback.

    The SUD Ventures Bootcamp, he says, both activated and validated his passion for bringing these innovations to patients. “After many years of basic, translational and clinical research on methadone all — supported by NIDA — I experienced that a ha moment of recognizing a potential opportunity to apply the findings to benefit patients at scale,” Kharasch says. “The NIDA-sponsored participation in the MIT SUD Ventures Bootcamp was the critical catalyst which ignited the inspiration and commitment to pursue commercializing our research findings into better treatments for opioid use disorder.”

    As next steps, Kharasch is seeking an experienced co-founder and finalizing IP protections. He remains engaged with the SUD Ventures network as mentors, industry experts, and peers offer help with advancing this needed solution to market. For example, the program’s mentor, Nat Sims, the Newbower/Eitan Endowed Chair in Biomedical Technology Innovation at Massachusetts General Hospital (MGH) and a fellow anesthesiologist, has helped Kharasch arrange technology validation conversations within the MGH ecosystem and the drug development community.

    “Evan’s collaboration with the MGH ecosystem can help define an optimum process for commercializing these innovations — identifying who would benefit, how they would benefit, and who is willing to pilot the product once it’s available,” says.

    Kharasch has also presented his project in the program’s webinar series. Looking ahead, Kharasch hopes to involve MIT Sloan School of Management students in advancing his project through health care entrepreneurship classes, continuing the momentum that began with the SUD Ventures Bootcamp.

    The program and its research are supported by the NIDA of the National Institutes of Health. Cynthia Breazeal, a professor of media arts and sciences at the MIT Media Lab and dean for digital learning at MIT Open Learning, serves as the principal investigator on the grant.

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  • The most popular car you’ve never heard of

    The most popular car you’ve never heard of

    Xiaomi opened orders for the five-seat YU7 SUV earlier this week, with prices for the Model Y-sized EV starting from 253,500 yuan – right in the wheelhouse of the 263,500 yuan Tesla.

    However, not even Xiaomi could have predicted just how popular it would be, with company founder and CEO Lei Jun announcing massive interest in the YU7.

    “My goodness, in just two minutes, we received 196,000 paid pre-orders and 128,000 lock-in orders,” Lei said in a video after it launched last week. “We may be witnessing a miracle in China’s automotive industry.”

    Xiaomi YU7

    While not every one of the orders guarantees a sold vehicle, the circa-325,000 combined paid pre-orders and expressions of interest represents more than all vehicle sales in Australia between January and March 2025.

    It could also put a big strain on Xiaomi’s current production capacity of 150,000 vehicles, however a second factory with equal capacity is due to start operations within weeks.

    Of course, China is a significantly larger market, with the almost 18 million vehicles it produces and sells locally annually representing about two-thirds of the nation’s overall domestic sales.

    Last year, Tesla sold 480,309 examples of the Model Y in China, with all of those – as well as the versions of the electric SUV sold in Australia – being produced at its Shanghai factory.

    Like the Model Y’s relation to the Model 3 sedan, the YU7 is closely related to the SU7 sedan, based on the same Modena platform and offering similar electric motor and battery combinations.

    Variants start with the entry-level self-named YU7, producing 235kW and 528Nm from its rear electric motor, fed by a 96.3kWh LFP battery. The step-higher Pro adds a front electric motor, increasing outputs to 365kW and 690Nm.

    At the top of the range is the YU7 Max, which uses a 101.7kWh NMC battery to feed two more powerful electric motors, capable of producing up to 508kW and 866Nm.

    The YU7 sadly has no answer to the SU7’s Ultra variant, which can pump out approximately 1140kW, propelling it to the top of the EV lap-time leaderboard around the Nürburgring Nordschleife.

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  • VAMO proposes an alternative to architectural permanence | MIT News

    VAMO proposes an alternative to architectural permanence | MIT News

    The International Architecture Exhibition of La Biennale di Venezia holds up a mirror to the industry — not only reflecting current priorities and preoccupations, but also projecting an agenda for what might be possible. 

    Curated by Carlo Ratti, MIT professor of practice of urban technologies and planning, this year’s exhibition (“Intelligens. Natural. Artificial. Collective”) proposes a “Circular Economy Manifesto” with the goal to support the “development and production of projects that utilize natural, artificial, and collective intelligence to combat the climate crisis.” 

    Designers and architects will quickly recognize the paradox of this year’s theme. Global architecture festivals have historically had a high carbon footprint, using vast amounts of energy, resources, and materials to build and transport temporary structures that are later discarded. This year’s unprecedented emphasis on waste elimination and carbon neutrality challenges participants to reframe apparent limitations into creative constraints. In this way, the Biennale acts as a microcosm of current planetary conditions — a staging ground to envision and practice adaptive strategies.

    VAMO (Vegetal, Animal, Mineral, Other)

    When Ratti approached John Ochsendorf, MIT professor and founding director of MIT Morningside Academy of Design (MAD), with the invitation to interpret the theme of circularity, the project became the premise for a convergence of ideas, tools, and know-how from multiple teams at MIT and the wider MIT community. 

    The Digital Structures research group, directed by Professor Caitlin Mueller, applied expertise in designing efficient structures of tension and compression. The Circular Engineering for Architecture research group, led by MIT alumna Catherine De Wolf at ETH Zurich, explored how digital technologies and traditional woodworking techniques could make optimal use of reclaimed timber. Early-stage startups — including companies launched by the venture accelerator MITdesignX — contributed innovative materials harnessing natural byproducts from vegetal, animal, mineral, and other sources. 

    The result is VAMO (Vegetal, Animal, Mineral, Other), an ultra-lightweight, biodegradable, and transportable canopy designed to circle around a brick column in the Corderie of the Venice Arsenale — a historic space originally used to manufacture ropes for the city’s naval fleet. 

    “This year’s Biennale marks a new radicalism in approaches to architecture,” says Ochsendorf. “It’s no longer sufficient to propose an exciting idea or present a stylish installation. The conversation on material reuse must have relevance beyond the exhibition space, and we’re seeing a hunger among students and emerging practices to have a tangible impact. VAMO isn’t just a temporary shelter for new thinking. It’s a material and structural prototype that will evolve into multiple different forms after the Biennale.”

    Tension and compression

    The choice to build the support structure from reclaimed timber and hemp rope called for a highly efficient design to maximize the inherent potential of comparatively humble materials. Working purely in tension (the spliced cable net) or compression (the oblique timber rings), the structure appears to float — yet is capable of supporting substantial loads across large distances. The canopy weighs less than 200 kilograms and covers over 6 meters in diameter, highlighting the incredible lightness that equilibrium forms can achieve. VAMO simultaneously showcases a series of sustainable claddings and finishes made from surprising upcycled materials — from coconut husks, spent coffee grounds, and pineapple peel to wool, glass, and scraps of leather. 

    The Digital Structures research group led the design of structural geometries conditioned by materiality and gravity. “We knew we wanted to make a very large canopy,” says Mueller. “We wanted it to have anticlastic curvature suggestive of naturalistic forms. We wanted it to tilt up to one side to welcome people walking from the central corridor into the space. However, these effects are almost impossible to achieve with today’s computational tools that are mostly focused on drawing rigid materials.”

    In response, the team applied two custom digital tools, Ariadne and Theseus, developed in-house to enable a process of inverse form-finding: a way of discovering forms that achieve the experiential qualities of an architectural project based on the mechanical properties of the materials. These tools allowed the team to model three-dimensional design concepts and automatically adjust geometries to ensure that all elements were held in pure tension or compression.

    “Using digital tools enhances our creativity by allowing us to choose between multiple different options and short-circuit a process that would have otherwise taken months,” says Mueller. “However, our process is also generative of conceptual thinking that extends beyond the tool — we’re constantly thinking about the natural and historic precedents that demonstrate the potential of these equilibrium structures.”

    Digital efficiency and human creativity 

    Lightweight enough to be carried as standard luggage, the hemp rope structure was spliced by hand and transported from Massachusetts to Venice. Meanwhile, the heavier timber structure was constructed in Zurich, where it could be transported by train — thereby significantly reducing the project’s overall carbon footprint. 

    The wooden rings were fabricated using salvaged beams and boards from two temporary buildings in Switzerland — the Huber and Music Pavilions — following a pedagogical approach that De Wolf has developed for the Digital Creativity for Circular Construction course at ETH Zurich. Each year, her students are tasked with disassembling a building due for demolition and using the materials to design a new structure. In the case of VAMO, the goal was to upcycle the wood while avoiding the use of chemicals, high-energy methods, or non-biodegradable components (such as metal screws or plastics). 

    “Our process embraces all three types of intelligence celebrated by the exhibition,” says De Wolf. “The natural intelligence of the materials selected for the structure and cladding; the artificial intelligence of digital tools empowering us to upcycle, design, and fabricate with these natural materials; and the crucial collective intelligence that unlocks possibilities of newly developed reused materials, made possible by the contributions of many hands and minds.”

    For De Wolf, true creativity in digital design and construction requires a context-sensitive approach to identifying when and how such tools are best applied in relation to hands-on craftsmanship. 

    Through a process of collective evaluation, it was decided that the 20-foot lower ring would be assembled with eight scarf joints using wedges and wooden pegs, thereby removing the need for metal screws. The scarf joints were crafted through five-axis CNC milling; the smaller, dual-jointed upper ring was shaped and assembled by hand by Nicolas Petit-Barreau, founder of the Swiss woodwork company Anku, who applied his expertise in designing and building yurts, domes, and furniture to the VAMO project. 

    “While digital tools suited the repetitive joints of the lower ring, the upper ring’s two unique joints were more efficiently crafted by hand,” says Petit-Barreau. “When it comes to designing for circularity, we can learn a lot from time-honored building traditions. These methods were refined long before we had access to energy-intensive technologies — they also allow for the level of subtlety and responsiveness necessary when adapting to the irregularities of reused wood.”

    A material palette for circularity

    The structural system of a building is often the most energy-intensive; an impact dramatically mitigated by the collaborative design and fabrication process developed by MIT Digital Structures and ETH Circular Engineering for Architecture. The structure also serves to showcase panels made of biodegradable and low-energy materials — many of which were advanced through ventures supported by MITdesignX, a program dedicated to design innovation and entrepreneurship at MAD. 

    “In recent years, several MITdesignX teams have proposed ideas for new sustainable materials that might at first seem far-fetched,” says Gilad Rosenzweig, executive director of MITdesignX. “For instance, using spent coffee grounds to create a leather-like material (Cortado), or creating compostable acoustic panels from coconut husks and reclaimed wool (Kokus). This reflects a major cultural shift in the architecture profession toward rethinking the way we build, but it’s not enough just to have an inventive idea. To achieve impact — to convert invention into innovation — teams have to prove that their concept is cost-effective, viable as a business, and scalable.”

    Aligned with the ethos of MAD, MITdesignX assesses profit and productivity in terms of environmental and social sustainability. In addition to presenting the work of R&D teams involved in MITdesignX, VAMO also exhibits materials produced by collaborating teams at University of Pennsylvania’s Stuart Weitzman School of Design, Politecnico di Milano, and other partners, such as Manteco. 

    The result is a composite structure that encapsulates multiple life spans within a diverse material palette of waste materials from vegetal, animal, and mineral forms. Panels of Ananasse, a material made from pineapple peels developed by Vérabuccia, preserve the fruit’s natural texture as a surface pattern, while rehub repurposes fragments of multicolored Murano glass into a flexible terrazzo-like material; COBI creates breathable shingles from coarse wool and beeswax, and DumoLab produces fuel-free 3D-printable wood panels. 

    A purpose beyond permanence 

    Adriana Giorgis, a designer and teaching fellow in architecture at MIT, played a crucial role in bringing the parts of the project together. Her research explores the diverse network of factors that influence whether a building stands the test of time, and her insights helped to shape the collective understanding of long-term design thinking.

    “As a point of connection between all the teams, helping to guide the design as well as serving as a project manager, I had the chance to see how my research applied at each level of the project,” Giorgis reflects. “Braiding these different strands of thinking and ultimately helping to install the canopy on site brought forth a stronger idea about what it really means for a structure to have longevity. VAMO isn’t limited to its current form — it’s a way of carrying forward a powerful idea into contemporary and future practice.”

    What’s next for VAMO? Neither the attempt at architectural permanence associated with built projects, nor the relegation to waste common to temporary installations. After the Biennale, VAMO will be disassembled, possibly reused for further exhibitions, and finally relocated to a natural reserve in Switzerland, where the parts will be researched as they biodegrade. In this way, the lifespan of the project is extended beyond its initial purpose for human habitation and architectural experimentation, revealing the gradual material transformations constantly taking place in our built environment.

    To quote Carlo Ratti’s Circular Economy Manifesto, the “lasting legacy” of VAMO is to “harness nature’s intelligence, where nothing is wasted.” Through a regenerative symbiosis of natural, artificial, and collective intelligence, could architectural thinking and practice expand to planetary proportions?

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  • Harnessing Plankton Research Is Crucial To Inform

    Harnessing Plankton Research Is Crucial To Inform

    An international publication led by Plymouth Marine Laboratory highlights how upgrading current plankton models is critical to understanding the scale of global climate issues. 

    Plankton may be small, but they power the planet. feeding marine life and underpinning global biogeochemical cycles. Yet the models used to simulate their influence on ocean ecosystems have not kept pace with developments in understanding of how biology and ecology functions, according to a new publication led by PML’s Professor Kevin Flynn. 

    Plankton models form the core of marine ecosystem simulators, used from regional resource and ecosystem management through to climate change projections, and are essential for us to predict what the future may hold for our planet, and prepare accordingly. 

    However, in the perspectives paper, ‘More realistic plankton simulation models will improve projections of ocean ecosystem responses to global change’, published July 1 in the scientific journal Nature Ecology & Evolution, a team of over 30 international experts argue that plankton models need updating to reflect contemporary knowledge, requiring urgent joint attention from both empiricists and modelers. 

    “Plankton are mainly microscopic organisms that grow in the ocean (and also in inland waters) that support the base of the food chain. No plankton—no fish, no sharks, no whales, no seals, no coral, etc. However, the diversity of the plankton is critical; that biodiversity cannot be best compressed into just a few groups, yet invariably that is what happens in models,” said Flynn.

    “Additionally, photosynthetic members of plankton play a role similar in magnitude to those of plants on land in producing oxygen and fixing carbon dioxide. They have had a transformational impact on how Earth evolved, and are likely to have a huge role in how our planet responds to climate change. ”

    Given that plankton play such a vital role in the natural processes of our planet, plankton models are central to our understanding of how oceans respond to global change. But the authors warn these tools do not sufficiently reflect what science now knows about plankton physiology, diversity, and their roles in ecosystem functioning. 

    “We’re using simulation tools built on 30 to 50-year-old concepts to understand the most complex and rapidly changing ecosystems on Earth. And that’s a real problem – not just for science, but for policy and for wider society. We need to be sure that models describe the ecophysiology of these organisms in a realistic manner,” explains Professor Flynn. 

    This disconnect could have serious consequences, from underestimating biodiversity shifts to missing key drivers of marine productivity and carbon cycling. Using models with over-simplified conceptual cores runs the risk of getting the “right” results (aligning with what data are available) for the wrong reasons, giving a false sense of confidence for using such models in projecting into the future. 

    The paper calls for a transformation in how plankton are modeled and how modelers and empiricists work together. Among the key recommendations are: 

    • Greater collaboration between empirical scientists and modelers, especially during model development 
    • Better accounting for aspects of real-world ecological complexity, known to be of critical importance, in core model design 
    • New tools that allow engagement with the development of simulation models by scientists that lack specialist coding skills 
    • Investment in “digital twin” platforms for plankton research – new-generation models that can simulate realistic biological processes and inform decision-making under global change 

    The authors urge the scientific community to treat modeling as a core tool in plankton ecology and in teaching activities – just as molecular biology revolutionized the science from the 1980s onward, so too must simulation modeling become embedded in plankton research. 

    This work was supported by the UK’s Natural Environment Research Council as part of the “Simulating Plankton” project, contributing to the UN Decade of Ocean Science and the Digital Twins of the Ocean (DITTO) initiative.

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