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A randomized controlled trial conducted in 18 public hospitals in Kenya finds that the the addition of glucocorticoids to standard care for severe community-acquired pneumonia (CAP) reduced the risk of death by 16%.

For the pragmatic, open-label trial, published last week in the New England Journal of Medicine, a team led by researchers at the Kenya Medical Research Institute assigned adult CAP patients without a clear indication for glucocorticoids to receive either standard care or standard care plus oral low-dose glucocorticoids for 10 days.

Of the 2,180 patients, none required intensive care, 1,089 were assigned to glucocorticoids within 48 hours after hospital admission, and 1,091 were assigned to standard care. The median patient age was 53 years.

“Adjunctive glucocorticoids may reduce mortality among patients with severe community-acquired pneumonia (CAP) in well-resourced settings,” the authors wrote. “Whether these drugs are beneficial in low-resource settings with limited diagnostic and treatment facilities is unclear.”

Balancing benefits with risk of metabolic complications

By 30 days, 22.6% of glucocorticoid recipients and 26.0% in the standard-care group had died (hazard ratio, 0.84). Rates of adverse and serious adverse events (SAEs) were similar in the two groups.

Although hyperglycemia is mostly controllable, blood glucose monitoring is difficult in overburdened sub-Saharan hospitals.

The trial’s pragmatic nature means that the results are likely to be more relevant to patients in sub-Saharan Africa than to those in high-resource settings, the researchers said. “On the basis of our findings, adjunctive glucocorticoids could represent a low cost intervention to reduce the high case fatality associated with CAP in sub-Saharan Africa,” they wrote.

In an editorial in the same journal, Arthur Kwizera, MD, of Makerere University College of Health Sciences in Uganda, and Martin Dunser, MD, of Johannes Kepler University in Austria, noted that hyperglycemia (high blood glucose) occurred in 16.6% of glucocorticoid recipients.

“Although hyperglycemia is mostly controllable, blood glucose monitoring is difficult in overburdened sub-Saharan hospitals,” they wrote. “As the prevalence of diabetes is increasing across Africa, introducing glucocorticoid therapy without strengthened laboratory and nursing capacity may put patients at risk and requires a nuanced balance of the survival benefits and metabolic complications.”

Collaboration Focuses on Next-Generation Design, Efficiency, and Scalability for AI Computing Infrastructure

AUSTIN, Texas, Nov. 3, 2025 /PRNewswire/ — Digital Realty (NYSE: DLR), a leading global provider of cloud- and carrier-neutral data center, colocation, and interconnection solutions, today announced a further collaboration with NVIDIA focused on advancing the design and deployment of next-generation AI infrastructure at Digital Realty’s campus in Manassas, Northern Virginia.

The site is home to NVIDIA’s newly announced AI Factory Research Center, which supports several key initiatives, including the NVIDIA Omniverse DSX blueprint for AI factories and digital twin for gigascale AI facilities, implementation of advanced liquid cooling technologies, and exploration of innovative approaches to power management and energy efficiency. These efforts are designed to benefit individual deployments and support best practices that advance the broader industry.

Digital Realty’s global infrastructure expertise addresses the unique challenges of AI workload deployment at scale. Through active engagement across multiple facilities and design initiatives, the teamwork is helping to define new standards for AI-optimized data center infrastructure.

“The infrastructure requirements for AI are fundamentally different from traditional data center workloads, and meeting these demands requires deep collaboration between infrastructure providers and technology innovators,” said Chris Sharp, Chief Technology Officer at Digital Realty. “Our work with NVIDIA represents a shared commitment to solving the complex technical challenges that enable AI deployment at scale, from advanced cooling solutions to power optimization and network architecture.”

Digital Realty’s portfolio includes key markets like Northern Virginia, where the company operates advanced, AI-ready infrastructure designed to support the most demanding computational workloads. These facilities feature high-density power capabilities, sophisticated cooling systems, and robust connectivity that aligns with the requirements of modern AI applications.

Digital Realty’s approach emphasizes flexibility and customer collaboration, working closely with leading technology companies to optimize infrastructure for specific workload requirements while maintaining the reliability and efficiency that enterprise customers demand.

About Digital Realty
Digital Realty brings companies and data together by delivering the full spectrum of data center, colocation, and interconnection solutions. PlatformDIGITAL®, the company’s global data center platform, provides customers with a secure data meeting place and a proven Pervasive Datacenter Architecture (PDx®) solution methodology for powering innovation, from cloud and digital transformation to emerging technologies like artificial intelligence (AI), and efficiently managing Data Gravity challenges. Digital Realty gives its customers access to the connected data communities that matter to them with a global data center footprint of 300+ facilities in 50+ metros across 25+ countries on six continents. To learn more about Digital Realty, please visit digitalrealty.com or follow us on LinkedIn and X.

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Digital Realty
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SOURCE Digital Realty Trust