Category: 3. Business

Q: Could you summarize the key efficacy findings from the OrigAMI-4 trial, particularly response rates, duration of response, and progression-free survival, in this heavily pretreated population with head and neck squamous cell carcinoma?
Kevin Harrington, MD, PhD, FRCP, FRCR, FRSB: We presented data from the OrigAMI-4 phase 1b/2 study in patients with recurrent or metastatic head and neck cancer who had received prior treatment with an immune checkpoint blocker and a platinum-based chemotherapy.

We reported data on two populations: the safety population of 86 patients who received at least 1 dose of the drug and the efficacy population of 38 patients who had at least 2 tumor assessments or had stopped treatment for any reason. The efficacy data relate only to that smaller subset of patients.

In that group, we observed an overall response rate of 45%, with a further 45% showing disease stabilization. When we looked at the lesions themselves, 82% showed evidence of shrinkage—clear evidence of the drug’s efficacy. In the efficacy-evaluable population, the median duration of response was over seven months, median progression-free survival was 6.8 months, and median overall survival was not yet reached. These findings show that single-agent subcutaneous amivantamab, delivered on a 3-week schedule, is very efficacious in this disease.

Q: Given that these patients had progressed on both checkpoint inhibition and platinum-based chemotherapy, how clinically meaningful are the responses seen with amivantamab in this setting?
Harrington: This group of patients is very difficult to achieve responses in. Previously, single-agent chemotherapy or investigator’s choice therapies—such as cetuximab, another EGFR-targeted drug—typically achieve response rates in the single digits or low teens, usually between 5% and 15%.

To see a response rate as high as 45% in this group of patients is, we believe, clinically meaningful and hopefully leads to patient benefit.

Cloud-native architecture and high-density baseband processing improves operational efficiency, performance and TCO

Herndon, VA., 20 October 2025 – ST Engineering iDirect, a global leader in satellite communications, today announced the general availability of Intuition 1.1, its next-generation ground system. Built on cloud-native, multi-orbit architecture, this release introduces advanced capabilities designed to unify satellite operations, enhance adaptability and maximize efficiency.

The foundation of Intuition is its efficient, cloud-native architecture, which reduces compute resource requirements and is further enhanced by high-density processing savings with the XBB baseband solution. Together, these elements can reduce hardware requirements by up to 70%, significantly lowering the total cost of ownership (TCO). Its modular, microservices-based design enables seamless, low-risk deployments, including rapid feature upgrades with minimal operational disruption, while flexible cloud deployment options ensure scalability, efficiency and performance for any operational need.

“Our vision with Intuition is to redefine agility and intelligent operations across the satellite industry,” said Sridhar Kuppanna, CTO and SVP of Engineering at ST Engineering iDirect. “With its cutting-edge architecture, robust APIs to facilitate analytics, and seamless readiness for 5G NTN, Intuition empowers customers to stay ahead in the rapidly changing connectivity landscape. Our agile development practice, and accelerated release delivery cycles will ensure that our customers have access to new capabilities and ongoing innovation to drive growth.”

Intuition 1.1 integrates ST Engineering iDirect’s award-winning Mx-DMA® MRC return waveform technology with global bandwidth management and advanced mobility, enabling dynamic multi-orbit bandwidth pooling, automated resource allocation and a faster response to network demands. This combination dramatically enhances performance, reduces costs and optimizes resource allocation to support growing connectivity requirements. Additionally, satellite network resource orchestration APIs further empower operators with comprehensive control over ground and space assets, enabling them to fully leverage advancements in software-defined satellites.

Intuition, paired with ST Engineering iDirect’s AI-powered analytics platform, drives advanced network optimization and operational performance. Designed for the future, Intuition enables seamless adoption of emerging 3GPP standards and sets the stage for 5G NTN roaming in upcoming releases. By deploying Intuition today, satellite operators can maximize their return on investment, support high-density growth and maintain readiness for the next wave of industry innovation.

*****

Media contact:
Martyn Gettings Tank PR
Email: martyn.gettings@tank.co.uk

21 October 2025

Allen & Gledhill advised Renew Group Private Limited (“RGPL”) on its sale of approximately 14.42% of the ordinary shares in UltraGreen.ai Private Limited to, among others, Anchor VI Pte. Ltd. (“65 Equity Partners”), Verde Taano Pte. Ltd. (“Vitruvian Partners”) and AGP Healthcare Fund VCC (“August Global Partners”), at an equity valuation of US$1.3 billion.

Advising RGPL was Allen & Gledhill Partner Rhys Goh.

Leveraging competitive market trends and insights for a winning year-end strategy

As consumers ready their carts for the year’s biggest sales events, brands and agencies across Southeast Asia gear up for their final, crucial push of the year.

Navigate the hyper-competitive peak season with insights into ad spend trends, the retail industry’s top advertisers and competing creative strategies.

Inside this report, you’ll discover:

Crucial industry trends: Understand how retail and manufacturing advertisers in Southeast Asia are spending year on year.

Industry insights into spend activity: See who the top players within the industry are.

Competing creative strategies: Get a preview of in-market messaging and creative trends, alongside the promotions and price points of top competitors.

[Paris, France, October 21, 2025] At the Network X telecom summit, leading research firm Omdia, together with Huawei and industry partners, released the Telco Cloud Manifesto: Building an Intelligent Telco Cloud Infrastructure for Service Innovation in the Mobile AI Era.

This marks the industry’s first white paper dedicated to the intelligent Telco Cloud, offering a fresh global perspective on telecom infrastructure and providing valuable guidance for operators as they transition into the AI era.

The white paper says the industry is moving toward 5G-A and AI, with Telco Cloud at the heart of this transformation. Around the world, operators are ramping up investments in container platforms and AI technologies while exploring how AI can improve core networks. Survey findings show that more than 60% of operators believe Telco Cloud should support AI training and inference tasks.

To meet this demand, telecom infrastructure must accelerate its evolution from being primarily based on general-purpose computing to AI infrastructure (AI-infra).

Over the past decade, cloudification of telecom networks has driven the adoption of layered architectures and expanded the technology choices of operators. But this shift has also introduced significant integration and O&M challenges, including time-consuming cross-vendor verification, complex cross-layer fault detection, CNF upgrade dependencies, and resource scheduling between VMs and containers. With the rise of AI applications, operators now face the added task of integrating heterogeneous computing power to optimize networks. This further increases system complexity.

In this context, as noted in the white paper, an increasing number of operators are choosing full-stack deployment solutions in order to balance cloud-native capabilities with operational simplicity. Key advantages of this approach include:

• Pre-integration that shortens the verification cycle and accelerates service rollout
• Unified automation frameworks that improve the efficiency of upgrades and O&M
• Direct Kubernetes upgrades to target versions, reducing maintenance costs
• System-level verification that ensures component compatibility and improves reliability
• End-to-end (E2E) performance optimization from the OS to the container platform and network elements (NEs), delivering an experience beyond what layered architectures can provide.

The white paper further emphasizes that future telecom infrastructure must address both evolution and performance. It should support a smooth transition from VMs to containers while protecting existing investments, while delivering carrier-grade performance through traffic offloading and hardware acceleration. To overcome the limitations of traditional CPU-centric architectures, the white paper advocates introducing high-speed peer-to-peer interconnection to converge general-purpose and intelligent computing. This allows for efficient collaboration across diverse computing resources.

In addition, the white paper calls for building an AI enablement platform that offers model management, scheduling, and acceleration capabilities. Such a platform will help operators rapidly develop and deploy AI applications, unlocking the full potential of network intelligence.

The white paper is available here: https://omdia.tech.informa.com/commissioned-research/articles/telco-cloud-manifesto

The release of this white paper signals the acceleration of the Telco Cloud’s evolution from cloud-native infrastructure to AI infrastructure. Additionally, it underscores the industry’s collective commitment to shaping the future of intelligent Telco Cloud. Huawei reaffirms its readiness to work with global partners to drive innovation and open a new chapter in the mobile AI era.

Samsung recognized for AI leadership and accelerating adoption

Samsung Electronics recently announced that it has been recognized by Interbrand, a global brand consultancy, as the 5th-ranked global brand for the sixth year in a row. Interbrand releases its list of “Best Global Brands” each year. For this year’s list, Samsung recorded a brand value of $90.5 billion, upholding its position as the only Asian company to remain in the global top five since 2020.

According to Interbrand, Samsung Electronics’ evaluation was positively influenced by:

• Strengthened AI competitiveness across the company’s business divisions
• Enhanced customer experiences through unified integration across products
• Focused investment in AI-related semiconductors
• Execution of a customer-centric brand strategy

“Through AI innovation and open collaboration, Samsung has worked to ensure that more customers can experience AI in their daily lives,” said Won-Jin Lee, President and Head of Global Marketing Office at Samsung Electronics. “Moving forward, we will continue to focus on benefits for customers including in health and safety so that Samsung can grow into an even more beloved brand.”

Under the vision of “Innovation for All,” Samsung consistently strives to make AI accessible to more customers worldwide.

This year, Samsung reinforced its leadership in mobile AI with the continued advancement of Galaxy AI, aiming to make it available on 400 million devices within the year driving the democratization of AI. In Consumer Electronics (CE), Samsung has expanded AI competitiveness by introducing AI technologies tailored to each product category, such as Vision AI and Bespoke AI.

Through open collaboration with diverse partners, Samsung has enhanced personalized AI experiences for customers, while also providing industry-leading security with Samsung Knox.

In semiconductors, Samsung has been addressing the growing demand for AI with a comprehensive portfolio across cloud, on-device, and physical AI. This includes actively responding with advanced products including HBM, high-capacity DDR5, LPDDR5X and GDDR7.

Beyond AI, Samsung continues to enhance the accessibility of its products and services and drive sustainable innovation across all business divisions. This includes energy savings through energy-efficient appliances connected via SmartThings.

Samsung’s Recognized Efforts in Each Business Division

Mobile

• Leading the mobile AI era and driving the popularization of AI with Galaxy AI
• Strengthening foldable category leadership with the launch of Galaxy Z Fold7 and Z Flip7
• Enhancing customer trust through strengthened privacy and security technologies
• Expanding health services through advanced wearables, Samsung Health enhancements, and open collaboration

Networks

• Reinforcing leadership in AI-powered virtualized Radio Access Networks (vRAN) and Open RAN
• Consistently innovating technologies to support various 5G use cases, including high quality streaming and gaming

• Leading the technical standardization of 6G

• Enhancing partnerships with customer companies and communicating the sustainability aspects of Samsung’s network technology

Visual Display

• Solidifying global leadership in TVs, soundbars, and gaming monitors
• Innovating viewing with rich AI features based on Vision AI
• Enhancing The Frame and Art Store services to deliver personalized art TV experiences
• Expanding content offerings through partnerships in TV Plus, entertainment, gaming, and music

Digital Appliances

• Maintaining global leadership in categories such as refrigerators and washing machines through consistent product innovation and advanced AI capabilities
• Providing differentiated convenience and advanced AI experiences through SmartThings integration
• Expanding Bespoke AI appliance leadership across energy efficiency, usability, performance, and design

Semiconductor

• Operating a diverse portfolio across cloud, on-device, and physical AI applications
• Maintaining leadership in mobile and automotive semiconductors, including DDR, SSD, LPDDR, UFS, and Auto SSD
• Continuing development and investment in innovative solutions like CMM-D and HBM
• Sharing vision and industry leadership through influential tech events

Interbrand’s Best Global Brands are ranked based on brand value evaluation, which involves a comprehensive analysis of the company’s financial performance and outlook, the influence of the brand on customer purchases, and brand competitiveness (including strategy, empathy, differentiation, customer engagement, consistency, trust, and more). The ranking is one of the world’s longest-standing brand value evaluations, widely recognized for its credibility.

SINGAPORE, Oct. 21, 2025 – Royal Caribbean’s Ovation of the Seas has returned to Singapore for a season of spectacular getaways to Southeast Asia’s most sought-after destinations. From now through March 2026, families and holidaymakers alike can look forward to everything from weekend escapes to longer adventures packed with world-class thrills, chill, entertainment and dining experiences for every type of traveller.

“Families remain at the centre of everything we do, and our ships are designed to bring everyone together through unforgettable shared moments – whether it’s exploring local cultures, enjoying world-class entertainment or trying new adventures at sea,” said Chad Grospe, vice president and managing director, Asia-Pacific, Royal Caribbean. “With Ovation’s return to Singapore, holidaymakers can enjoy the ease of beginning their holiday closer to home, while enjoying Royal Caribbean’s unique blend of adventure and relaxation.”

Royal Caribbean continues to introduce new experiences specially designed for the Asian market, bringing the best of the brand to the region.

“We are delighted to welcome Royal Caribbean’s Ovation of the Seas back to Singapore for her seasonal homeport deployment. Aligned with our Tourism 2024 vision, this exciting return strengthens Singapore’s appeal as a vibrant holiday getaway, offers families unique options to explore the region from Singapore, and underscores the cruise industry’s confidence in Singapore as their regional hub,” said Jacqueline Ng, Director, Cruise, Singapore Tourism Board.

On Ovation, holidaymakers can enjoy a wide array of Royal Caribbean’s signature highlights and experiences. Adventurers can soar on RipCord by iFLY, the first skydiving simulator at sea, or take in panoramic views from the North Star all-glass observation capsule, which rises over 90 metres above the ocean. For indoor fun, SeaPlex—the largest indoor activity space at sea—offers everything from bumper cars and roller skating to arcade games and a sports court. The excitement continues with world-class entertainment, from live music to jaw-dropping shows at the transformational Two70, where guests can enjoy cutting-edge performances that combine aerial acrobatics, robotics and projection-mapped visuals.

With 17 dining options to choose from, travellers can indulge in flavours from around the globe. Guests can enjoy fresh Italian dishes at Jamie’s Italian by Jamie Oliver, Japanese favourites at Izumi, imaginative creations at Wonderland, premium steaks at Chops Grille, Mediterranean-inspired dishes at Solarium Bistro, or casual classics at the ever-popular Windjammer Café.

This season, Ovation will offer a variety of adventures from Singapore, ranging from 3- to 5-night getaways to 8-night journeys, with visits to popular destinations like Penang, Malaysia; Phuket, Thailand, and Bali, Indonesia.

• Short 3- to 4-night getaways make it easy for travellers to recharge while exploring nearby favourites such as Penang where guests can wander through George Town’s colourful street art and heritage architecture, while sampling local street food and browsing bustling markets. In Phuket, guests can unwind on golden beaches by day and experience lively night markets after dark.

• For those seeking a little more time away, the 5-night Penang & Phuket Overnight journey combines the highlights of both destinations. Guests can enjoy authentic hawker fare, explore cultural landmarks and take part in island-hopping excursions for immersive experiences.

• Guests can embark on a longer 8-night Bali Adventure, spending two full days in Celukan Bawang and Benoa in Bali. Vacationers can relax on Bali’s stunning beaches, visit coastal temples and experience the vibrant local culture. The journey also includes a visit to Lombok, Indonesia, known for its pristine shorelines, laid-back charm and natural beauty.

• Ovation will also celebrate the festive season with a 4-night Christmas getaway, departing 24 December 2025 to Penang and Phuket. Plus, to ring in the New Year, an 8-night journey departing 28 December 2025 to Bali combines regional highlights with unforgettable holiday experiences.

Holidaymakers can now book their adventures on Ovation of the Seas at Royal Caribbean’s website.

About Royal Caribbean
Royal Caribbean, part of Royal Caribbean Group (NYSE: RCL), has delivered memorable vacations for more than 50 years. The cruise line’s game-changing ships and exclusive destinations revolutionize vacations with innovations and an all-encompassing combination of experiences, from thrills to dining and entertainment, for every type of family and vacationer. Voted “Best Cruise Line Overall” for 22 consecutive years in the Travel Weekly Readers Choice Awards, Royal Caribbean makes memories with adventurers across more than 300 destinations in 80 countries on all seven continents, including the line’s top-rated exclusive destination, Perfect Day at CocoCay in The Bahamas. 

Media can stay up to date by following @RoyalCaribPR on X and visit www.RoyalCaribbeanPressCenter.com. For additional information or to book, vacationers can visit www.RoyalCaribbean.com, call (800) ROYAL-CARIBBEAN or contact their travel advisor.

Related Images

Ovation of the Seas features a lineup of experiences, including the FlowRider surf simulator, skydiving at RipCord by iFly, and SeaPlex – the largest indoor activity space at sea – with bumper cars, full-size sports court, roller-skating rink and more.

Ovation of the Seas cuenta con una gama de experiencias, incluyendo el simulador de surf FlowRider, paracaidismo en RipCord de iFly y SeaPlex, el espacio de actividad interior más grande en el mar, con autos chocadores, una cancha de deportes de tamaño completo, pista de patinaje sobre ruedas y más.

North Star, the signature glass observation capsule, takes guests more than 300 feet above the ocean on Quantum Class ships like Quantum, Anthem and Ovation of the Seas.

The largest indoor activity space at sea, SeaPlex is exclusively featured on Royal Caribbean’s Quantum and Quantum Ultra Class ships, such as Anthem, Ovation and Spectrum of the Seas. There are experiences for the whole family like bumper cars, a full-size sports court and spots to kick back on the sidelines. 

Credit SBW-Photo

Ovation of the Seas’ top-deck adventures include Royal Caribbean’s signature FlowRider surf simulator and skydiving on RipCord by iFly.

The Singapore-homeported Ovation of the Seas.

Ovation of the Seas Fast Facts

(Bloomberg) — Asian shares extended gains Tuesday, buoyed by upbeat US earnings and indications that tensions between Washington and Beijing were easing.

A regional stock gauge topped its record close as most major Asian benchmarks advanced. Chinese shares gained at the open, while Japanese equities strengthened amid expectations Sanae Takaichi will become the nation’s first female prime minister. US equity futures rose after the S&P 500 and Nasdaq 100 each gained more than 1% Monday, while gold held near highs amid bubble concerns.

Asian markets are finding fresh momentum after the S&P 500 logged its biggest two-day gain since June on Monday, with about 85% of companies beating profit estimates so far. Strong third-quarter earnings helped temper worries over the US government shutdown, while hopes of progress in US-China trade talks lifted sentiment. President Donald Trump reiterated his threat to follow through on a tariff hike on Chinese goods “if there isn’t a deal” by Nov. 1, but said he plans to meet President Xi Jinping next week.

“The strong start to the week on Wall Street has helped Asian markets to open higher today,” said Nick Twidale, chief market analyst at AT Global Markets in Sydney. “A softening in trade concerns has also helped overall sentiment, with investors taking a glass 75% full look at the market at the moment.”

Earlier this month, markets were roiled as Trump raised the prospect of a sky-high tariff rate, citing China’s “hostile” export controls. Soybean futures rallied Monday, with growers holding out hope that Trump will make a deal with China to restart stalled American exports.

Separately, shares of critical mineral producers jumped in Sydney on Tuesday after Trump signed an agreement with Australian Prime Minister Anthony Albanese to boost America’s access to rare earths and other key materials.

The Treasury 10-year yield traded below 4% and the dollar was steady early Tuesday as falling oil prices eased concern about the inflation backdrop before the release of consumer-price data.

After a delay caused by the US government shutdown, the Bureau of Labor Statistics is set to release September’s consumer price index on Friday. The data, originally slated for Oct. 15, will give Federal Reserve officials a key reading on inflation ahead of their Oct. 30 policy meeting.

The data may take on greater importance due to the government shutdown-driven data drought, said Rick Gardner at RGA Investments. He still sees a Fed cut in October and noted that a key test will be Big Tech earnings, with investors looking for clarity on how spending on artificial intelligence is leading to profitability.

“We are seeing the typical seasonal volatility in October, but the recent swings have been relatively shallow by historical standards, as the buy-the-dip mentality appears to be in play,” Gardner said.

Some of the main moves in markets:

Stocks

S&P 500 futures were little changed as of 10:32 a.m. Tokyo time Nikkei 225 futures (OSE) rose 1.1% Japan’s Topix rose 0.6% Australia’s S&P/ASX 200 rose 0.9% Hong Kong’s Hang Seng rose 1.1% The Shanghai Composite rose 0.3% Euro Stoxx 50 futures rose 0.2% Currencies

The Bloomberg Dollar Spot Index was little changed The euro was little changed at $1.1648 The Japanese yen was little changed at 150.72 per dollar The offshore yuan was little changed at 7.1208 per dollar The Australian dollar was little changed at $0.6516 Cryptocurrencies

Bitcoin fell 0.8% to $110,281.06 Ether fell 1% to $3,961.26 Bonds

The yield on 10-year Treasuries was little changed at 3.98% Japan’s 10-year yield declined one basis point to 1.660% Australia’s 10-year yield declined three basis points to 4.12% Commodities

West Texas Intermediate crude fell 0.5% to $57.22 a barrel Spot gold fell 0.2% to $4,347.44 an ounce This story was produced with the assistance of Bloomberg Automation.

–With assistance from Winnie Hsu.

©2025 Bloomberg L.P.