Category: 3. Business

  • Soon-to-be-axed 7am Manchester-London train will still run – but without passengers | Rail industry

    Soon-to-be-axed 7am Manchester-London train will still run – but without passengers | Rail industry

    The good news for rail travel between Manchester and London is that a morning train will continue to link England’s biggest cities in under two hours. The bad news: passengers will no longer be able to get onboard.

    The rail regulator has axed one of Britain’s fastest and most lucrative intercity services, the 7am Avanti West Coast from Manchester Piccadilly to London Euston, as part of a timetable shake-up that will take effect in mid-December.

    What will heap on frustration for passengers, as well as the operator, is that the exact same train service will continue to run between the stations from 7am each weekday: crewed, fast and empty.

    The train and staff still need to travel from Manchester as they are rostered to operate subsequent services out of Euston on the new December timetable, under rail’s complex planning.

    The bizarre situation is expected to continue for five months or more until the next timetable change in May, meaning the service could run empty more than 100 times. The move has left rail insiders fuming at the decision by the Office of Rail and Road (ORR).

    Business travellers from the north may mourn the end of the express train, non-stop after Stockport in Greater Manchester and timed conveniently to arrive in the capital just before 9am. Revenue collectors even more so: current single fares on the peak-time service are priced at £193, rising to £290 for first class.

    The industry expert and rail writer Tony Miles said: “It will be on the platform – people will be able to see it, touch it, watch it leave. But they won’t be able to get on. The taxpayer will be paying five days a week for empty trains.”

    Passengers board an Avanti West Coast service at Manchester Piccadilly railway station. Photograph: Christopher Thomond/The Guardian

    The service began in 2008 when Virgin Trains ran intercity trains on the west coast mainline but was suspended during the coronavirus pandemic and Avanti’s subsequent troubles, and reinstated when Avanti returned to a full timetable in 2024.

    As the only service completing the journey so quickly, at one hour 59 minutes, it has long been a major marketing asset, allowing operators to advertise trains running between England’s capital and the northern city in less than two hours.

    Network Rail, as well as Avanti, supported the continuation of the service with passengers, arguing the train would be “using capacity regardless” on the network.

    A senior industry source said: “People paid a lot of money to get on that train. If we ever need justification for a guiding mind in the railway, this is the example.”

    The train has been removed as the regulator tries to ensure the overall reliability of the railway in the new timetable on 15 December. The new schedule will mainly affect the UK’s other major rail artery, the east coast mainline, but the industry is wary of any potential disruption after the widespread cancellations and delays sparked by the last comparable overhaul, the May 2018 timetable fiasco.

    The ORR said the service was no longer feasible in the new timetable as new open access train services, run by First Group’s Lumo to Stirling in Scotland, were due to start. Fare revenue will go to the private operator rather than the Department for Transport, as is the case under the Avanti contract.

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    Avanti will be running more services to the north-west overall under the new timetable, the ORR said. Photograph: Christopher Thomond/The Guardian

    An Avanti spokesperson confirmed that its fastest service would still run with crew, but no passengers. They said: “We are disappointed with the Office of Rail and Road’s decision not to grant access rights from December for four weekday services that we currently operate, including the 07.00 from Manchester to London fast service, as well as requiring a Sunday service which currently runs from Holyhead to London to terminate at Crewe. This will clearly impact those customers who already use these services.”

    The ORR said: “Our decision on the Manchester-London service was based on robust evidence provided by Network Rail that adding services within firebreak paths on the west coast mainline would have a detrimental impact on performance. We identified that this service would run in one of those paths.

    “If Avanti operates the service as empty coaching stock, [it] can be run more flexibly – delayed or rerouted – than a booked passenger service. This can assist with performance management and service recovery during disruption.”

    Firebreak paths are planned gaps or unused time in the timetable to allow for disruption to services.

    Avanti will be running more services to the north-west overall under the new timetable, and other applications from open access companies on the line had been declined, the ORR said.

    The fastest trains linking Manchester and London will now take about 2 hours 15 minutes, with those wishing to arrive in the capital by 9am having to catch a 6.29am train.

    Northern business leaders hit out at the decision. Henri Murison, the chief executive of the Northern Powerhouse Partnership, said the ORR in backing open access was “denying business people in Manchester access to London on a vital fast peak service” and sacrificing revenue, adding: “Great British Railways’ future finances are being undermined by a regulator disregarding the interests of taxpayers, who will pick up the bill for this poor decision in the name of competition.”

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  • A Practical Study of Data Requirements for Self-Supervised Learning in Medical Image Analysis

    A Practical Study of Data Requirements for Self-Supervised Learning in Medical Image Analysis

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  • Xi stresses improving long-term mechanisms for cyberspace governance

    BEIJING, Nov. 29 — Xi Jinping, general secretary of the Communist Party of China (CPC) Central Committee, has emphasized the importance of improving long-term mechanisms for cyberspace governance.

    Presiding over a group study session of the Political Bureau of the CPC Central Committee on Friday, Xi called for sustained efforts to cultivate a clean, healthy and sound online environment.

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  • ‘Keeping founders poor doesn’t help anyone’

    ‘Keeping founders poor doesn’t help anyone’

    David Abrahamovitch averages four cups of coffee a day; a fitting dedication to caffeine as the founder of Grind (and the father of two young children). But, he confesses, he wasn’t always a coffee aficionado. The first Grind café, opened in 2011, came about after Abrahamovitch, then aged 25, inherited his father’s mobile phone shop on London’s Shoreditch roundabout.

    On the advice of a friend, he transformed the phone shop — where he’d once worked as a teen — into a Melbourne-style café. It was a success, but real growth came a decade later, when Grind launched online sales of pods and beans during Covid.

    Today, despite having 13 cafés — including its newest branch in Dubai airport — online sales make up the lion’s share of the company’s revenue.

    The business was last valued at £150mn, with annual revenue at £30mn for the 2023-24 year. It employs 350 staff.

    “A lot of people get into coffee because they love coffee,” Abrahamovitch says. “I got into coffee because I had a building.”

    CV

    Born: London, 1985

    Education: Bancroft’s School, London (1992-2003)

    UCL, Economics degree (2003-07)

    Career: 

    • Barclays Capital, intern (2003)

    • Banco Santander — Abbey Financial Markets, Internship programme (2004)

    • InterResolve, Founding Team (2007-13)

    • Grind, Launched 2011; Full time since 2014

    Lives: With wife Francesca of 15 years, and two daughters in east London

    You grew up on the outskirts of east London. What was your family background like?
    My parents didn’t come from much at all, but both were smart and worked hard. In their generation, that was enough.

    My mum was in the corporate world, and gave us stability. She was paying the mortgage and the school fees. My private education was amazing — it was cool to be clever there.

    My dad was a classic entrepreneur, setting up shops across different industries. It was very much feast and famine, but it looked more fun than going to an office. My sister is also an entrepreneur now [running Dusk, the bar drinks app], so there’s a clear influence.

    By the time I was born, my dad had moved into mobile phone repairs, spotting that it was going to become a big thing. From the age of 12, I would work all summer in the repair shop. I watched how to do sales calls, account management and customer engagement. I learned more from that about running a business than I did from my economics degree. I actually worked full-time during my final university year for a dispute resolution tech start-up, initially backed by [venture capital firm] Balderton.

    I also did a few summer banking internships during my degree, but I knew immediately I had no interest in it as a career.

    What inspired the first Grind store and how did you finance it?
    When dad died, I had to figure out what to do with the shop he’d left behind on Shoreditch roundabout. It was a long-term lease, and the rent was £8,000 a quarter. My mum paid the rent for a few quarters, and I got a small amount from selling off the customer base. The shop had been wasted as a mobile store — the area had really transformed and my dad had always talked about changing it. When I mentioned it to my friend Kaz, from Melbourne, he said: “Let me put some money in. Let’s do a café with proper coffee.”

    I didn’t have enough money to fit out the first one. I thought we would be doing it for £50,000 and it ended up costing nearly £200,000 because we had to do so much to make it commercial. I magicked a quarter of it up myself from credit cards and stocks. The rest we really had to beg, borrow and steal. I remember filling out business bank pages to borrow £20,000 for coffee machines and ended up having to agree personal guarantees. We even did some of the work ourselves, such as sanding down the stools — it was the first and the last time I’ve done any DIY. 

    I called my mum the night before opening to ask for a few hundred pounds for the float. She literally came with a bank bag of £400 or £500 in five, 10 and 20 pence coins. That £500 really was the last of what we had. We budgeted for a loss in the few months, but, luckily, people came in. The flat white caught on. 

    For the first few years, I couldn’t afford to go full-time at Grind. I stayed working full-time at the Balderton-backed tech start-up. It nearly killed me getting the first one open. Then in January 2014, we raised £1mn. At that point, I thought I owed it to the investors to go all in. Plus, by then, we were making £15,000 a week, helped further once we got our late licence and could serve espresso martinis after 5pm. 

    When did the business really take off?
    In 2019, after we did a £3.5mn crowdfunding raise, we invested in building out a new direct-to-consumer arm. I wanted to make high-quality coffee pods without the sustainability issues, and we launched that in January 2020. 

    I thought maybe the new website could generate one store’s worth of revenue. But by April, during lockdown, we were doing crazy numbers. One minute I was telling all the staff they had to go home. Then my phone was exploding with Shopify notifications. We had £2mn in our account earmarked for two sites in Canary Wharf and the South Bank, but ended up putting it all into the direct-to-consumer part of the business.

    We didn’t even have all the stuff we needed, but I was just like: “Do not stop, no one touch that website. I don’t care if we don’t have the stock. We’ll figure it out.”

    There were moments when I thought we would lose the business completely because of Covid. It was crazy to go from that in March 2020 to 18 months later, the business being worth way more.

    It was only after that point that Grind became a cohesive brand. Beforehand, it had just been Soho Grind or Shoreditch Grind and so on. We became a different entity [Kaz James was a co-founder for the first physical stores, but Abrahamovitch is the sole founder of the broader Grind entity].

    What was Grind’s approach to cracking such a competitive sector?
    We knew from the start we didn’t want any other coffee brands sold at our cafés. A roaster took pity on us and was like, sure, I’ll give you 20 bags a week of your own white label blend!

    In terms of flavour profile, we haven’t really changed much since. If you go to speciality grocery stores and get an espresso, it’ll be quite flowery and delicate. And coffee guys like that. But the reality is 95 per cent of the coffees we’re selling are flat whites and cappuccinos. And that [type of] coffee doesn’t work that well with milk. So it was about having something where you can still really taste the coffee coming through the milk, with a little bit of chocolate and nuts — that little bit of natural sweetness. Italians think their way is the best, with their dark, fast, $1 espressos. I love Italians’ obsession with food and drink, but I don’t necessarily agree.

    How do you manage your personal finances now?
    The direct-to-consumer boom prompted us to bring in a big investor [Richard Koch, who co-founded LEK Consulting]. Since then, I’ve sold down my stake a little in various rounds to de-risk a bit. That’s allowed me to buy an amazing house and all the stuff that comes with having two kids. 

    Apart from my house, the vast majority of my money is invested in exchange traded funds, stocks and a pension. I also have seven or so angel investments. I mostly back founders I know.

    On paper, 80 per cent of my wealth is still in the business. I think I’ll grow it faster there than in the stock market. But equally, I’ve got two kids and I want to make sure that if, for some reason I’m no longer here, there’s plenty to pay the school fees and have a nice life. Although my wife [Victoria Beckham’s make-up artist] is successful in her own right.

    I subscribe to the American attitude that keeping founders poor doesn’t help anyone. They’re just more stressed about the day-to-day and won’t want to take risks in the same way. My lead investor has been super supportive in terms of allowing me to take money off the table.

    What do you spend money on?
    My main splurge now is definitely holidays. I’m never going to be able to travel with a three- and a four-year-old again. Plus, they won’t want to go on holiday with me in another 10 years probably. When it comes to material things, it’s as everyone says — as soon as you can afford the stuff, you no longer want it.

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  • H&M caught in the middle of a fast-fashion battle

    H&M caught in the middle of a fast-fashion battle

    H&M’s chief executive has urged European politicians to create a level playing field for fashion retailers in areas such as tax, chemical regulations, purchasing practices and workers’ rights to combat unfair competition from Chinese rivals such as Shein and Temu.

    Daniel Ervér told the Financial Times that the Swedish fast-fashion retailer was on “a very long journey” towards increased profitability after ceding its crown as the world’s largest fashion chain to Zara’s Spanish owner in “an industry that is changing at a furious pace”.

    He added: “I don’t think we have seen a level playing field. If you don’t pay taxes, if you don’t comply with chemical regulations, don’t adhere to purchasing practices, protect the social rights of workers, that’s not a responsible way of conducting business. There’s a responsibility for lawmakers to ensure there is a fair playing field, [otherwise] it will weaken our competitive strength as European companies.”

    H&M has been increasingly squeezed from above by the likes of rivals Zara, and from below by cheaper rivals including Shein, Temu and Primark.

    Zara has been pushing upmarket with tactics such as displaying limited-edition collections at high-profile events such as Paris Fashion Week and revamping stores designed by leading architects. H&M has followed its lead to some degree in a bid to set itself apart from cut-price online rivals such as Shein and Temu, which benefited from sales surges during the pandemic.

    Ervér’s plan to turn around family-controlled H&M has focused on boosting profitability and putting the customer at the heart of its focus — both on display at the refitting of a central Stockholm store around the corner from its head office.

    The H&M’s central Stockholm store © Margareta Bloom Sandeback/FT
    Beauty section inside an H&M store reception area.
    Beauty products greet customers at the entrance to the store © Margareta Bloom Sandeback/FT
    Reception desk in front of a fitting room area with a black jacket on a rack and shelves displaying bags and folded clothes.
    Shoppers can scan a code in the fitting room to ask an employee to bring them a different size © Margareta Bloom Sandeback/FT

    The store is airy for an H&M location, with more space between displays and fewer clothes on show, while items from its upmarket Studio and Atelier ranges as well as beauty products greet customers at the entrance. Shoppers can scan a code in the fitting room to ask an employee to bring them a different size or order anything out of stock for home delivery.

    “Previously it was high-density but we wanted to break that. With the right product, we sell more with less. It becomes a more effective way of running the business,” said Johanna Klingspor, H&M’s head of creative development.

    The revamp is already bearing some fruit as Ervér also targets cost control. Operating margins fell from more than 20 per cent in 2010 to just 3 per cent in 2022. They reached 8.6 per cent in the third quarter this year, up from 5.9 per cent a year earlier.

    “What I recognised when stepping in is that this company has so much untapped potential . . . given how the competitive landscape has changed, we need to step up our game. We need to stop doing what doesn’t make a difference for the customer and really shift resources and money to what makes the difference,” said Ervér, who took over running H&M in February 2024.

    Shareholders have given his plans a cautious welcome. Shares are up about 16 per cent this year, but were higher just before he took over as well as before the pandemic.

    One top-10 shareholder said: “H&M were caught in between — not in Zara’s price point, and definitely not in Shein’s. They let the margins slide for too long.”

    A fashion analyst added: “Ervér’s elevation strategy is taking the company in the right direction as it helps to reduce the H&M brand’s exposure to value fashion — the most competitive segment of the market and the most exposed to competition from not only the likes of Shein, but also second-hand platforms.”

    But questions remain. H&M has historically sourced more of its clothes from Asia leaving it less nimble than Zara, which has more production closer to its biggest markets in Europe and the US. H&M’s need to discount some stock has led to volatility in both sales and gross margins.

    “We need to continue to become quicker. Nearshoring is one piece of the puzzle, but there are many others,” Ervér said. His aim is to have some items on sale between six and 10 weeks after the initial idea.

    The 44-year-old pointed to H&M presenting its latest collection at London Fashion Week for the first time in two decades. “That puts a lot of pressure on us to step up because you have the whole world, journalists, influencers, looking at you and assessing you.”

    H&M is controlled by the family of Stefan Persson, son of the company’s founder, who owns shares carrying 83 per cent of voting rights. He has gradually increased his ownership in recent years and many observers in Stockholm expect him eventually to take the company private.

    Daniel Ervér stands with hands in pockets at H&M head office, with office furniture and colourful fashion artwork in the background.
    Daniel Ervér at H&M’s head office © Margareta Bloom Sandeback/FT
    Clothing displays and mannequins with winter outfits in a brightly lit H&M store interior.
    H&M has historically sourced more of its clothes from Asia © Margareta Bloom Sandeback/FT
    A close-up of a white H&M Edition shirt on a hanger, with the collar and label visible.
    The company boasts 500 in-house designers © Margareta Bloom Sandeback/FT

    Ervér said he did not think it was “so provocative” to put customers ahead of investors. H&M had been “fortunate to have one large shareholder” and that satisfying all investors meant “being focused on the customer,” he added.

    The retailer is also making a push into second-hand through its Sellpy platform. Some of its stores, such as the one in central Stockholm, have curated second-hand sections that attract younger shoppers. Ervér said: “We see it becoming an important part of the way that you express yourself and the way you shop second-hand becomes a complement to the existing business.”

    Ervér disagrees with critics who say sustainability is incompatible with fast fashion: “To do fully sustainable collections for the richest people is not so difficult. The big challenge is to do it at scale.”

    He is happy that H&M has broken the link between growth and emissions, going up in sales and down in greenhouse gases although he concedes “we are far from done”.

    The Swedish group has a partnership with start-up Syre, a sister company to bankrupt battery maker Northvolt, to recycle polyester that recently expanded to include products from sporting goods group Nike.

    Ervér said that few customers “want to pay more” for green products but that entrepreneurship, creativity and policy should drive the change because it “won’t happen organically”.

    On competition, the H&M chief executive argued that the big disruption came a decade ago when digitalisation changed how people shop, as well lowering the barriers to entry in fashion. That opened up the market for a “completely new set of competitors” without physical stores.

    “We need to make sure we leverage the strengths of having 500 in-house designers, the strength of curating the experience, and really facilitating the shopping experience,” Ervér added.

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  • US dollar set for worst week since July as Fed rate cut looms

    US dollar set for worst week since July as Fed rate cut looms

    The U.S. dollar was heading for its worst weekly performance since late July on Friday as traders increased bets that the Federal Reserve will cut rates again next month.

    The dollar has dropped this week as traders conclude that weakening labor data will lead to more rate cuts, even as many Fed policymakers express concern about still-elevated inflation.

    “It feels like with the post-shutdown run of releases, it’s generally been soft … the data overall definitely leaned towards a cut,” said Eric Theoret, FX strategist at Scotiabank in Toronto.

    The U.S. federal government is releasing a backlog of economic data after reopening from a record 43-day shutdown.

    Fed funds futures traders are pricing in 87% odds of a cut at the conclusion of the Fed’s December 9-10 meeting, up from 71% a week ago, according to the CME Group’s FedWatch Tool.


    Fed officials will enter a blackout period on Saturday ahead of the meeting. The dollar index, which measures the greenback’s strength against a basket of six major peers, was last down 0.09% at 99.44, and on track for a 0.61% weekly loss, its largest since July 21. ANTICIPATION AHEAD OF BOJ MEETING

    Bank of Japan Governor Kazuo Ueda is due to speak on Monday, and traders will focus on whether he signals a likely rate increase at the BOJ’s December meeting, which could continue to lift the currency.

    “There’s obviously a lot of anticipation around the Bank of Japan meeting in December. Will they hike rates? Will they not hike rates? And up until now, Ueda has been reasonably non-committal/dovish and hasn’t really signaled a December hike yet,” said James Lord, head of FX and emerging market strategy at Morgan Stanley.

    “But with dollar-yen at these levels and the fiscal package that has been announced by the government, there’s a possibility that we will see a rate hike in the December meeting,” Lord said. Japanese Prime Minister Sanae Takaichi’s government on Friday finalised a $117 billion supplementary budget for this financial year to fund a massive stimulus package, most of which will be financed through new debt issuance.

    The Japanese yen strengthened 0.14% against the greenback to 156.09 per dollar.

    FOREX TRADING CALM AFTER CME OUTAGE An overnight outage due to a cooling issue at CME Group’s CyrusOne data centres halted trade on its widely-used currency platform and in stock and commodity futures. By 1335 GMT, trading had resumed after having been knocked out for over 11 hours, according to LSEG data.

    Currency markets appeared largely unfazed by the outage during U.S. hours, which came in already light trading volumes after Thursday’s U.S. Thanksgiving Day holiday.

    “Liquidity remains thin given that most participants executed month-end trades ahead of yesterday’s Thanksgiving holiday, and most major pairs are seeing choppy, but range-bound trading action with technical levels holding firm,” said Karl Schamotta, chief market strategist at Corpay in Toronto.

    The euro rose 0.06% to $1.1602.

    Sterling was little changed at $1.3237 and heading for its best weekly performance since early August with a gain of 1.09%, after British Finance Minister Rachel Reeves revealed her long-awaited budget this week.

    “Obviously (the budget) was garnering a lot of headlines, but it also felt like a lot of the bad news had been priced in. And overall, it feels like the market had a bit of a relief rally in the pound on Wednesday,” said Theoret.

    Reeves fought back on Thursday against criticism of the government’s spending plans, which will fund extra welfare spending by raising the country’s tax burden to a post-World War Two high. The Canadian dollar extended gains after data showed that Canada’s economy grew at a much faster pace than expected in the third quarter as crude oil exports and government spending boosted economic activity. The loonie was last up 0.39% versus the greenback at C$1.398 per dollar.

    In cryptocurrencies, bitcoin fell 0.38% to $91,052.

    (Reporting by Karen Brettell; Additional reporting by Ozan Ergenay; Editing by Ros Russell, Rod Nickel)

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  • How the Narrative Around TotalEnergies Is Evolving After Recent Analyst and Industry Shifts

    How the Narrative Around TotalEnergies Is Evolving After Recent Analyst and Industry Shifts

    TotalEnergies has seen its consensus analyst price target recently increase from $60.96 to $63.30. This signals a modest upward adjustment in analysts’ perceived fair value for the stock. The accompanying decline in the discount rate from 6.24% to 6.23% highlights a slightly more favorable risk outlook among market participants. Stay tuned to discover how you can track future shifts in sentiment and remain up to date on the evolving narrative surrounding TotalEnergies.

    Analyst Price Targets don’t always capture the full story. Head over to our Company Report to find new ways to value TotalEnergies.

    Analyst commentary on TotalEnergies has recently captured a spectrum of perspectives, reflecting both ongoing strengths and emerging reservations. The following summarizes the main themes from recent research coverage.

    🐂 Bullish Takeaways

    • Piper Sandler’s Ryan Todd raised the firm’s price target to $70 from $69 and emphasized resilient free cash flow generation and strong headline growth as ongoing positives for TotalEnergies, even as near-term crude oil outlook remains muted. The firm also highlights structural cost savings that continue to lower the company’s breakeven.

    • JPMorgan’s Matthew Lofting increased the price target to EUR 61 from EUR 60 and maintained an Overweight rating, which signals confidence in the company’s positioning and execution within its sector.

    • Several analysts positively note the company’s ability to adapt through cost controls and strategic capex adjustments, rewarding ongoing discipline amid shifting market conditions.

    🐻 Bearish Takeaways

    • RBC Capital’s Biraj Borkhataria lowered the price target to EUR 70 from EUR 75 and cited a cautious tone set by management at Capital Markets Day, with deliberate moves to brace for a weaker macro environment and notable capex cuts, particularly in the power segment.

    • BNP Paribas Exane’s Lucas Herrmann downgraded TotalEnergies to Neutral from Outperform with a price target of EUR 53, reflecting greater caution about the company’s short-term upside relative to its valuation and broader sector risks.

    • Scotiabank’s Paul Cheng, despite raising the price target to $67 from $65, described the revised estimates as disappointing compared to what industry margin indicators originally suggested, implying a tempered outlook despite the increase.

    Overall, while recent analyst updates acknowledge TotalEnergies’ execution strengths and financial resilience, more cautious voices reflect growing attention to macro uncertainty, valuation, and the sustainability of near-term growth.

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  • TAM Receptors Promising Therapeutic Targets in Rheumatoid Arthritis

    TAM Receptors Promising Therapeutic Targets in Rheumatoid Arthritis

    The TAM receptor family, which includes Tyro3, Axl, and MerTK receptors, has potential as a new therapeutic target for rheumatoid arthritis (RA) therapies, according to a new review published in Cell & Bioscience.1

    TAM receptors are broadly expressed throughout the body and seen as important regulators of immune homeostasis and inflammatory resolution, the authors explained. Previous research has shown that mice with a TAM deficiency experienced spontaneous chronic inflammation and autoimmune phenomena, which the authors said may be clinical precursors to RA.2

    In humans, the investigators noted that TAM receptors serve as a key inhibitory feedback mechanism.1

    “Blocking TAM signaling results in severe defects in the clearance of ACs (apoptotic cells), exacerbates systemic inflammation, and induces overactivation of the immune system, thereby contributing to the onset and progression of RA,” the authors wrote.

    Activation of TAM receptors, meanwhile, helps restore tissue integrity, in part by suppressing innate immune cell activation, enhancing AC clearance, and promoting tissue repair.

    However, the authors said the different TAM receptors have different roles to play in RA. Axl and MerTK have been shown to have protective benefits in RA.3 Tyro3 appears to exacerbate inflammation and joint destruction, they said.

    “This functional dichotomy suggests distinct therapeutic strategies: targeted activation of Axl/MerTK pathways may restore immune balance, whereas Tyro3 inhibition could mitigate synovitis and bone erosion,” the authors wrote, adding that a wave of research has been exploring ways to capitalize on our emerging understanding of TAM receptors.1

    One possible application is the use of soluble forms of TAM receptors (sTAM) as biomarkers for evaluating RA disease status, the authors said.

    “These soluble variants are generated through metalloproteinase-mediated cleavage of the extracellular domains of their membrane-bound counterparts and are markedly elevated in the synovial fluid of RA patients, showing promise as indicators of disease activity, severity, and prognosis,” the authors said.

    Studies have shown correlations between different sTAMs and clinical characteristics, including a link between serum sTyro3 levels and systemic inflammation. However, the authors said it will be important to come up with standardized detection methods for sTAMs, which they said require further investigation and validation.

    A number of TAM-targeted therapies are currently in clinical development, the authors noted. The focus, they said, is largely on small molecules that can inhibit receptor-ligand binding and/or suppress kinase activity. The investigators said most of the development thus far has centered on oncology indications, but they said the therapies’ mechanisms of action suggest they can potentially be effective in autoimmune diseases.

    Approximately 20 small-molecule TAM inhibitors have entered the clinical evaluation phase, of which 15 remain in active commercial development. They said oncological applications of the therapies have centered on using TAM inhibitors to mediate drug resistance as part of combination strategies.

    Additionally, the authors said a diverse range of multiple small-molecule TAM inhibitors are also in the preclinical stage.

    “These emerging compounds highlight the continuing diversification of TAM-targeting strategies in preclinical development,” they said.

    Future therapeutic development in the RA context “should focus on receptor-specific modulators to overcome structural homology challenges and explore combination strategies with existing therapies,” the authors wrote.

    The authors said understanding TAM signaling and its correlation with different diseases and stages will be necessary before drug developers can realize the full therapeutic potential of the TAM pathway.

    References

    1. Dai M, Yang X, Yao F, et al. From pathogenesis to therapeutic targeting: new insight into TAM receptors in rheumatoid arthritis. Cell Biosci. 2025;15(1):157. Published 2025 Nov 19. doi:10.1186/s13578-025-01503-w

    2. Waterborg CEJ, Koenders MI, van Lent PLEM, van der Kraan PM, van de Loo FAJ. Tyro3/Axl/Mertk-deficient mice develop bone marrow edema which is an early pathological marker in rheumatoid arthritis. PLoS One. 2018;13(10):e0205902. Published 2018 Oct 18. doi:10.1371/journal.pone.0205902

    3. Gao L, He C, Yang A, et al. Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Cell Commun Signal. 2023;21(1):195. Published 2023 Aug 3. doi:10.1186/s12964-023-01133-0

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  • Brent Oil Prices Steady, WTI Sees 1% Increase Amid Ongoing Russia-Ukraine Talks, ETEnergyworld

    Brent Oil Prices Steady, WTI Sees 1% Increase Amid Ongoing Russia-Ukraine Talks, ETEnergyworld

    Crude oil futures traded flat to higher as ongoing Russia-Ukraine peace talks and an upcoming OPEC+ meeting kept geopolitical risks and potential output changes in focus.

    Brent crude oil futures were flat on Friday and US crude futures rose as drawn-out Russia-Ukraine peace talks kept geopolitical risks elevated and traders kept an eye on Sunday’s OPEC+ meeting for clues about potential output changes.

    US West Texas Intermediate crude futures resumed trading after being frozen due to a system outage at exchange operator CME Group, blamed on a cooling issue at CyrusOne data centres. Brent trades on the Intercontinental Exchange, or ICE.

    Front-month Brent crude futures for January, which expire on Friday, were up 6 cents, or 0.09 per cent, at $63.40 a barrel at 12:44 p.m. EDT (1744 GMT). The more active February contract changed hands at $63.24, up 37 cents, or 0.59 per cent.

    WTI crude traded at $59.47 a barrel, up 82 cents, or 1.4 per cent, from Wednesday’s close. There was no settlement on Thursday due to the Thanksgiving holiday in the US

    Longest losing streak since 2023

    Despite being up more than 1 per cent for the week, both contracts are headed for a fourth straight monthly loss, their longest losing streak since 2023, as expectations for higher global supply weighed on prices.

    The strength of fuel refining profit margins has supported crude demand in some places, but the bearish impact of an expected oil surplus is pressuring prices, said Rystad analyst Janiv Shah.

    US oil production rose to record highs in September, data from the Energy Information Administration showed on Friday, deepening concerns that the market is heading towards a surplus.

    US crude oil output rose 44,000 barrels per day in September to a record 13.84 million bpd, according to the EIA data.

    A Reuters survey of 35 economists and analysts showed respondents expect Brent to average $62.23 per barrel in 2026, down from October’s forecast of $63.15. The benchmark has averaged $68.80 per barrel so far in 2025, LSEG data showed.

    Signs that a peace deal between Ukraine and Russia might be close pushed oil prices down sharply earlier this week, but they have recovered over the past three sessions as negotiations dragged on.

    “Futures had been anticipating some sort of a peace agreement which has kept pressure on prices,” Dennis Kissler, senior vice president of trading at BOK Financial, said in a note on Friday.

    “Still, little is known at this time, and no agreement will likely mean even tighter sanctions on Russia’s oil exports.”

    On Sunday, OPEC+ is likely to leave oil output levels unchanged at its meetings and to agree on a mechanism to assess members’ maximum production capacity, two delegates from the group and a source familiar with the group’s talks told Reuters.

    Saudi Arabia, the world’s biggest oil exporter, is expected to lower its January crude price for Asian buyers for a second month to its lowest in five years, under pressure from ample supplies and the surplus outlook, sources told Reuters on Friday.

    • Published On Nov 29, 2025 at 07:54 AM IST

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  • Assessing Interactive Brokers Group (IBKR) Valuation as Analyst Confidence Grows Ahead of Earnings

    Assessing Interactive Brokers Group (IBKR) Valuation as Analyst Confidence Grows Ahead of Earnings

    Interactive Brokers Group (IBKR) has caught investor attention as upward revisions to earnings estimates suggest growing confidence in the company ahead of its next quarterly report. This has fueled renewed market activity around the stock.

    See our latest analysis for Interactive Brokers Group.

    After a strong showing in the latest session, Interactive Brokers Group’s stock reflects building momentum, with a 1-day share price gain of 1.29% and a robust 42.5% share price return so far this year. Despite some short-term fluctuations, the company’s longer-term track record remains impressive, boasting a 36.7% total shareholder return over one year and an enormous 385% over five years.

    If you’re curious about what’s catching investor attention lately, it could be an ideal moment to broaden your scope and discover fast growing stocks with high insider ownership

    With upgraded analyst outlooks and a history of outperformance, is Interactive Brokers Group still trading at an attractive value, or has the market already factored in all of its future growth potential?

    With a fair value estimate of $76.82 from the most widely followed narrative, Interactive Brokers Group’s last close of $65.02 stands notably below this projection. This intensifies the spotlight on the stock’s future prospects.

    The introduction of new products and enhancements, such as the strengthened ATS with new liquidity providers and order types, enhancements to the IBKR Financial Advisor Portal, and the launch of securities lending for Swedish stocks, suggests potential for increased trading activity and higher commission revenue. Record client credit balances at $107.1 billion, up 36% over last year, indicate a strong trust in the platform and substantial funds availability for trading, possibly leading to higher net interest income from margin loans as clients leverage their positions.

    Read the complete narrative.

    Want to know what’s powering this aggressive price target? The secret may lie in new product launches and surging client assets. But there is a bold forecast for future profit margins and growth rates hidden beneath the surface. Find out what assumptions drive this valuation narrative and see if you agree with the analyst consensus.

    Result: Fair Value of $76.82 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, unexpected shifts in global interest rates or intensifying competition in key markets could challenge Interactive Brokers Group’s growth trajectory and valuation outlook.

    Find out about the key risks to this Interactive Brokers Group narrative.

    Looking from a different angle, Interactive Brokers Group trades at a price-to-earnings ratio of 31.6x, which is higher than both its industry peers at 23.6x and a market fair ratio of 21.1x. The gap signals the market may be pricing in a lot of future optimism, which could create valuation risk if expectations shift. Could a high rating eventually align with the company’s long-term reality?

    See what the numbers say about this price — find out in our valuation breakdown.

    NasdaqGS:IBKR PE Ratio as at Nov 2025

    If you have a different perspective or want to dive into the numbers yourself, it’s easy to craft your own storyline in just minutes. Do it your way

    A great starting point for your Interactive Brokers Group research is our analysis highlighting 2 key rewards and 1 important warning sign that could impact your investment decision.

    Smart investors never settle for one opportunity. Expand your outlook and seize potential winners before the crowd does with these powerful ways to generate new ideas on Simply Wall Street:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include IBKR.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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