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Category: 3. Business
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Crude oil price analysis: Market uncertainties cap US government deal craze – Invezz
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Strong Execution and Backlog Momentum, but Valuation Stretched vs Peers
This article first appeared on GuruFocus.
RTX Corporation (formerly Raytheon Technologies) is one of the world’s largest aerospace and defense companies, created through the merger of Raytheon and United Technologies. The company operates through three major segments: Collins Aerospace, which supplies aircraft systems, avionics, and interiors; Pratt & Whitney, known for its advanced jet engines and geared-turbofan technology; and Raytheon, a global leader in defense electronics, missile systems, radar, and intelligence solutions.
This dual-engine structure, balancing commercial aerospace with defense and government programs, gives RTX a uniquely diversified revenue base. The commercial side captures cyclical growth tied to global air travel and fleet modernization, while the defense portfolio provides steady, long-term cash flows supported by government budgets and multi-year contracts. This blend offers resilience through market cycles and positions RTX as a rare large-cap player with both growth and stability within the aerospace-defense sector.
RTX posted another strong quarter, with adjusted revenue of US$22.48 billion, up roughly 12 % year-on-year and ahead of consensus estimates of about US$21.3 billion. Organic growth stood at approximately 13 %, reflecting broad-based momentum even after accounting for divestitures. Adjusted EPS rose 17 % to US$1.70 versus US$1.45 in Q3 2024, while GAAP EPS came in at US$1.41, including about US$0.29 in acquisition-related adjustments. Free cash flow more than doubled to US$4.0 billion, underscoring improved execution and working-capital efficiency.
The company’s backlog climbed to a record US$251 billion, of which US$148 billion is from commercial programs and US$103 billion from defense, providing multi-year revenue visibility. Collins Aerospace delivered US$7.62 billion in sales (+8 %) and US$1.19 billion in operating profit (+9 %), supported by strong commercial OE (+16 %) and aftermarket (+13 %) growth. Pratt & Whitney reported US$8.42 billion in sales (+16 %) and US$751 million in profit (+26 %), led by a 23% surge in aftermarket and 15% military growth. Raytheon posted US$7.05 billion in sales (+10%) and US$859 million in profit (+30%), driven by robust demand across land, air, and naval defense programs.
Reflecting this performance, management raised full-year 2025 guidance. Adjusted sales are now expected to be between US$86.5 and 87.0 billion (up from US$84.7585.5 billion), and adjusted EPS to be between US$6.10 and 6.20 (up from US$5.805.95), while maintaining free cash flow guidance at US$7.07.5 billion.
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Rs 1 lakh monthly to Rs 10 crores net worth: CA explains 3 habit formula that builds crorepatis ‘mathematically’
India is entering a phase of rapid economic growth, with markets, innovation, and investment opportunities expanding at an unprecedented pace. For individuals under 40, this creates a unique chance to build substantial wealth if approached strategically. Chartered accountant Nitin Kaushik recently highlighted that young professionals have the potential to become crorepatis by adopting disciplined financial habits and leveraging the long-term growth of India’s economy with the power of compounding.In a post shared on X, Kaushik emphasizes that financial discipline is the foundation of wealth accumulation. “If you save at least half of your income consistently, you create the base for substantial wealth over time,” he points out. For someone earning ₹1 lakh per month, saving 50% sets the stage for significant growth without drastically changing lifestyle choices.
Smart Investment Choices
Saving alone is not enough. Investing wisely is the next step. Kaushik recommends putting around 70% of your savings into equities, such as systematic investment plans (SIPs), index funds, or carefully selected quality stocks. Equities, he explains, benefit from India’s growth trajectory and the long-term upward trend of markets.
“Investing consistently in equities allows your money to grow exponentially,” Kaushik notes. By focusing on long-term growth rather than short-term market fluctuations, investors can harness the power of compounding.Consistency Over Decades
Perhaps the most critical factor, according to Kaushik, is time. Staying invested for 20 years or more can turn a monthly SIP of ₹1 lakh into more than ₹10 crore, assuming a reasonable 12% annual return. “This isn’t a fantasy or luck. It’s mathematics working quietly behind the scenes,” he adds.Kaushik stresses that investors do not need to engage in daily trading or attempt to time the market. Instead, the focus should be on believing in India’s long-term economic growth and remaining invested through market cycles.
The Three Habits To Build Wealth
From Kaushik’s insights, three habits emerge for wealth creation before 40:
- Save aggressively: Set aside at least 50% of monthly income.
- Invest wisely: Allocate the majority of savings to equities for long-term growth.
- Be patient and consistent: Maintain investments for decades to leverage compounding.
Those who adopt discipline, strategic investment, and patience now could enjoy a life of financial security and wealth accumulation in the years to come.
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Tesla Stock Hit This Record Right Before Its Slide – Barron's
- Tesla Stock Hit This Record Right Before Its Slide Barron’s
- Tesla stock reverses higher as tech shakes off Thursday’s big sell-off Yahoo Finance
- Tesla’s Shares Tumble: A Tactical Entry Point for ETF Investors? Nasdaq
- Tesla (TSLA) technical analysis – Tesla (NASDAQ:TSLA) Benzinga
- Tesla stock falls sharply as Elon Musk’s $1 billion share buy faces possible loss MSN
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Single-Tablet Bictegravir/Lenacapavir Effective After Treatment Switch
Patients with
HIV may be able to switch from a multi-tablet regimen to a single-tablet regimen, as a single-tablet regimen of bictegravir 75 mg/lenacapavir 50 mg (BIC/LEN) was found to beequally effective when patients switched from multi-tablet regimens to treat their HIV diagnosis. These results come from the ARTISTRY-1 clinical trial, a phase 3 study.1Results from the ARTISTRY-1 trial had previously been published earlier in the year, with ARTISTRY-1 showing BIC/LEN was able to keep all but 1 of 103 participants virally suppressed compared with all 25 patients who remained virally suppressed on complex antiretroviral therapy (ART) regimens
through 24 weeks .2 These new results update the previous study to evaluate the efficacy through 48 weeks.Patients on complex regimens are often not able to benefit from single-tablet regimens due to drug-drug interactions, pre-existing resistance, and tolerability, which can leave them with a higher burden of pills to take. Those who participated in ARTISTRY-1 were taking between 2 and 11 pills per day to continue to be virally suppressed. The single-tablet regimen of BIC/LEN aims to address these patients by offering a combination therapy in a single tablet.
“Gilead developed the first single-tablet complete regimen for the treatment of HIV in 2006. Today, innovative single-tablet regimens are still needed to help suit people’s needs, modernizing treatment while helping to sustain viral suppression. By reducing the multi-tablet burden, we hope to improve health outcomes while expanding options,” said Jared Baeten, MD, PhD, senior vice president of clinical development at Gilead Sciences.1
BIC is an integrase strand transfer inhibitor that has a higher barrier to resistance and is only used in combination. LEN has been approved as a method of pre-exposure prophylaxis but has also been used to treat multi-drug-resistant HIV in adults, with its use approved in multiple countries.
Participants of the ARTISTRY-1 trial were aged 18 years or older,2 were virally suppressed for at least 6 months before screening, and were on a stable, complex ART regimen for at least 6 months due to either intolerance, previous viral resistance, or a contraindication to existing single-tablet regimens. Participants were recruited from Australia, Canada, the US, the Dominican Republic, and Puerto Rico.
For the phase 3 part of the study, participants were randomized 2:1 to either BIC/LEN or continued their baseline complex regimen. The study looked for a primary end point of viral suppression of less than 50 copies/mL after 48 weeks, as well as, change in baseline CD4 cell count and the occurrence of treatment-emergent adverse events (TEAEs).
In new results whose details will be revealed at a later date, researchers found that the primary efficacy end point of ARTISTRY-1 was met through 48 weeks and was well-tolerated in the patients.
“These ARTISTRY-1 trial results demonstrate that a combination regimen of bictegravir and lenacapavir maintains viral suppression in people living with HIV who would otherwise have to take a complex multi-tablet regimen. The findings are significant for those people, many of whom have lived with HIV for decades and who have medical comorbidities of aging and thus take many other medications as well,” said Chloe Orkin, MBE, clinical professor of Infection and Inequities at Queen Mary University of London.1
References
1. Gilead’s investigational single-tablet regimen of bictegravir and lenacapavir for HIV-1 treatment meets primary endpoint in phase 3 ARTISTRY-1 trial. News release. Gilead. November 13, 2025. Accessed November 14, 2025.
https://www.gilead.com/news/news-details/2025/gileads-investigational-single-tablet-regimen-of-bictegravir-and-lenacapavir-for-hiv-1-treatment-meets-primary-endpoint-in-phase-3-artistry-1-trial 2. Mounzer K, Slim J, Ramgopal M, et al. Efficacy and safety of switching to daily bictegravir plus lenacapavir from a complex HIV treatment regimen: a randomized, open-label, multicenter phase 2 study (ARTISTRY-1). Clin Infect Dis. 2025;80(4):881-888. doi:10.1093/cid/ciae522
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This Week in Oncology: FDA Approval Shakeups and Key SITC 2025 Data
This November has already provided many exciting developments across the multidisciplinary oncology world. Within the first half of the month alone, the FDA has been busy issuing new approvals and regulatory nods across different breast cancer, leukemia, and gynecologic malignancy populations. Additionally, presentations from the recent
2025 Society for Immunotherapy of Cancer Annual Meeting showcased novel treatment modalities that may show utility across various treatment settings.CancerNetwork® reported on these latest potential shakeups across oncology. Here are the top 5 takeaways of the week that may influence the future of the field.
#1: FDA Approves Pertuzumab Biosimilar in Breast Cancer Indications
The
FDA approved an interchangeable biosimilar formulation of pertuzumab (Perjeta) known as pertuzumab-dpzb (Poherdy), a HER2-neu receptor agonist, in different breast cancer populations.1Based on various comparisons of parameters related to safety and efficacy, pharmacokinetic data, clinical immunogenicity findings, and supportive clinical data, the agency determined that the biosimilar exhibited sufficient similarity to the reference product. The biosimilar is indicated for use in combination with agents like trastuzumab (Herceptin) across different treatment settings, including adults with HER2-positive metastatic breast cancer who have not received prior anti-HER2 treatment or chemotherapy for metastatic disease.
#2: FDA Approves Ziftomenib in R/R NPM1-Mutated Acute Myeloid Leukemia
Another key regulatory decision was the
FDA’s approval of ziftomenib (Komzifti) for patients with relapsed/refractory acute myeloid leukemia (AML) harboring NPM1 mutations, based on data from the phase 1b/2 KOMET-001/KO-MEN-001 trial (NCT04067336).2Topline results from the study showed that 21.4% (95% CI, 14.2%-30.2%) of evaluable patients achieved a complete response (CR) or CR with partial hematologic recovery. Additionally, in 66 patients with red blood cell and/or platelet transfusion dependence at baseline, transfusion independence at any 56-day post-baseline period occurred in 14 (21.2%).
#3: Mecbotamab Vedotin Shows Positive OS Results in Soft Tissue Sarcoma
Data presented at SITC 2025 showed that treatment with mecbotamab vedotin (Mec-V) elicited an overall survival (OS) benefit for those with treatment-refractory leiomyosarcoma, liposarcoma, or undifferentiated pleomorphic sarcoma in a phase 2 trial (NCT03425279).3Across the overall population, the median OS was 18.4 months (95% CI, 7.2-not evaluable [NE]) with Mec-V alone and 22.9 months (95% CI, 14.2-NE) with Mec-V plus nivolumab (Opdivo). Across different subgroups, the median OS was 19.0 months (95% CI, 7.9-29.9) for patients with leiomyosarcoma, 21.7 months (95% CI, 3.7-NE) for those with liposarcoma, and 21.5 months (95% CI, 5.0-NE) for those with undifferentiated pleomorphic sarcoma.
#4: Novel T-Cell Therapies Yield Decade-Long Remission in Epithelial Cancer
In other presentations shared at SITC 2025 , investigational cellular therapies demonstrated various benefits across different epithelial cancer populations.Findings from one single-center phase 2 trial (NCT05686226) showed that T cell receptor (TCR)–T-cell therapy could produce responses in a small cohort of patients with metastatic HPV-associated cancers.4 Moreover, another presentation on a different phase 2 trial (NCT01585428) highlighted 2 patients with metastatic cervical cancer who remained in CR for at least 10 years following a single infusion of tumor-infiltrating lymphocyte therapy.5
#5: FDA Approves Diagnostic Tool for Pembrolizumab Combo in Endometrial Cancer
In another notable decision from the FDA , the agency approved the Promega OncoMate® MSI Dx Analysis System as a companion diagnostic for identifying patients with microsatellite-stable endometrial carcinoma who may benefit from treatment with pembrolizumab (Keytruda) in combination with lenvatinib (Lenvima).6Previously, the agency approved pembrolizumab/lenvatinib for this endometrial carcinoma population in July 2021.7 This decision was based on findings from the phase 3 KEYNOTE-775 study (NCT03517449).
References
- FDA approves new interchangeable biosimilar to Perjeta. News release. FDA. November 13, 2025. Accessed November 14, 2025. https://tinyurl.com/2vzwt6ej
- FDA approves ziftomenib for relapsed or refractory acute myeloid leukemia with a NPM1 mutation. News release. FDA. November 13, 2025. Accessed November 14, 2025. https://tinyurl.com/2mcsxzuv
- Druta M, Pollack SM, Conley AP, et al. Median OS of 21.5 months among 44 patients with treatment-refractory leiomyosarcoma, liposarcoma, and undifferentiated pleomorphic sarcoma treated with mecbotamab vedotin, an AXL-targeting ADC. Presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting; National Harbor, MD; November 5-9, 2025.
- Norberg SM, Doran SL, Cao J, et al. Complete tumor regression of metastatic epithelial cancer following T cell receptor (TCR)-T cell therapy. Presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting; National Harbor, MD; November 5-9, 2025. Abstract 366.
- Norberg SM, Biswas A, Krishnamurthy S, et al. Decade-long epithelial cancer remissions from cellular therapy. Presented at the Society for Immunotherapy of Cancer (SITC) 2025 Annual Meeting; National Harbor, MD; November 5-9, 2025. Abstract 377.
- FDA approves Promega OncoMate MSI Dx Analysis System as companion diagnostic for KEYTRUDA in combination with LENVIMA in advanced endometrial carcinoma. News release. Promega. November 11, 2025. Accessed November 14, 2025. https://tinyurl.com/2jdnn7r7
- FDA grants regular approval to pembrolizumab and lenvatinib for advanced endometrial carcinoma. FDA. July 21, 2021. Accessed November 14, 2025. https://tinyurl.com/49hzfsvh
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Samsung and other South Korean firms pledge larger domestic investments after US tariff deal
SEOUL, South Korea — SEOUL, South Korea (AP) — Samsung Electronics and other major South Korean companies on Sunday announced fresh domestic investment plans at a meeting with President Lee Jae Myung, who hopes the moves will counter concerns that the firms would prioritize U.S. investments under a trade deal.
Lee’s meeting with business leaders came days after his government finalized a trade deal with the United States, in which Seoul pledged to invest $350 billion in U.S. industries in exchange for averting the Trump administration’s highest tariffs.
Samsung, a global leader in computer chips, said it will invest 450 trillion won ($310 billion) over the next five years to expand its domestic operations, including building another production line at its Pyeongtaek manufacturing hub to meet surging global semiconductor demands fueled by artificial intelligence.
Samsung said the new line, set to begin operations in 2028, is part of its broader effort to secure additional production capacity in anticipation of rising mid- to long-term demands for memory chips. The company also plans to build AI data centers in the country’s southwest South Jeolla Province and the southeastern city of Gumi to support government efforts to reduce the development gap between the greater Seoul metropolitan area and other regions.
Hyundai Motor Group, South Korea’s largest automaker, said it plans to invest 125 trillion won ($86.3 billion) from 2026 to 2030 to expand domestic research and development and advance new technologies such as AI, robotics and self-driving cars.
SK Group, another semiconductor powerhouse, and shipbuilders Hanwha Ocean and HD Hyundai also announced plans to increase their domestic investments. Both are central to South Korean commitments to boost the U.S. shipbuilding industry, a sector highlighted by President Donald Trump in negotiations with Seoul.
In his meeting with the companies’ chiefs, Lee credited the business sector for helping his government negotiate the trade deal with Washington but urged the companies to maintain strong domestic investments to ease concerns they might cut spending at home to invest more in America. He said his government is exploring various policy steps, including easing regulations, to help create a more favorable business environment for the companies.
SK Chair Chey Tae-won, whose group plans to invest at least 128 trillion won ($88.3 billion) domestically through 2028 with a focus on AI, said the finalization of trade talks with the United States eases uncertainties and paves way for bolder domestic investment.
The two governments on Friday released the details of the trade agreement, including $150 billion in South Korean investments in the U.S. shipbuilding sector and an additional $200 billion in other American industries, which Seoul says will be capped at $20 billion per year to prevent financial instability.
The United States agreed to reduce tariffs on South Korean cars and auto parts from 25% to 15%, and to apply tariffs on South Korean semiconductors on terms “no less favorable” than those granted to comparable competitors in the future.
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Falling mortgage rates bringing uneven relief – Mortgage Professional America
- Falling mortgage rates bringing uneven relief Mortgage Professional America
- South shows ‘early signs’ of recovery in property market, Auckland falls 1News
- Invercargill, Q’town lead home gains Otago Daily Times
- Hamilton house prices buck nationwide trend Waikato Times
- Tauranga home values fall 1.3% matching Whangārei SunLive
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What We Lose With Remote Work—and How to Minimize the Damage – The Wall Street Journal
- What We Lose With Remote Work—and How to Minimize the Damage The Wall Street Journal
- The workplace shift causing you to feel you’re picking up co-workers’ slack The Independent
- The secret to remote work that actually performs The Hill
- Why are remote workers feeling more drained than free? Here’s what study says The Times of India
- How Remote Work Provides Career Stability Built In
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The stock market faces big questions about the economy this week. How to be strategic as delayed data comes out. – Morningstar
- The stock market faces big questions about the economy this week. How to be strategic as delayed data comes out. Morningstar
- Week in review: The Nasdaq’s worst week since April, three trades, and earnings CNBC
- Disney, Coreweave, Occidental, Oklo, Flutter, and More Stocks to Watch This Week Barron’s
- Record-long government shutdown, valuation worries in focus for markets: What to watch this week Yahoo Finance
- Technical Support Levels, CPI and Other Key Things to Watch this Week Barchart.com
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