Category: 3. Business

Introduction

It is legally and ethically mandatory to provide patients with adequate information during a preoperative surgical consent consultation. Preoperative education serves not only as a vital communication tool between physician and patient but also holds forensic importance. Time constraints in surgical practice often limit the amount of time surgeons can dedicate to patients to inform them about the surgical procedure, risks, and postoperative care during the informed consent procedure. This can leave patients feeling underinformed and anxious about their upcoming surgery. With increasing constraints on medical staff resources and growing individual workloads, there is also an increasing interest in boosting efficiency, particularly using artificial intelligence (AI) [,].

Recent technological advancements have led to the development of large language model-based tools such as the AI chatbot ChatGPT, which demonstrate improved text analysis and generation capabilities that have the potential to greatly enhance patient education and outcomes [-]. Patients can ask specific questions regarding their planned surgical procedure and perioperative management and get in return answers relevant to their questions with a possibly high level of accuracy. The potential of AI, especially AI chatbots powered by generative pretrained transformers (GPTs) [,], is increasingly recognized for its ability to transform patient engagement []. However, the use of those tools also carries potential risks. Notably, the tools can produce inaccurate, misleading, and potentially harmful responses, often referred to as hallucinations []. Such hallucinations are expected to decrease with more advanced versions like GPT-4o []. Particularly promising is the use of methods such as retrieval-augmented generation (RAG), where the AI chatbot is provided with a database containing additional, subject-specific information, though the effects of such an approach on responses to patients’ questions have not yet been examined. Recent findings confirm that GPT-4 and GPT-4o exhibit exceptional accuracy and efficiency in language and reasoning capabilities [-]. However, they also emphasize the importance of developing more comprehensive benchmarks and robust evaluation frameworks, incorporating qualitative assessments, human judgment, and detailed error analysis [,]. This study, therefore, also aims at investigating prompt-based assessment in the informed consent procedure.

Given its high degree of standardization and the development of robust postoperative care protocols in recent years, hip arthroplasty serves as an exemplary model for exploring the integration of AI into clinical procedures and patient education frameworks [-]. Total hip arthroplasty (THA) is a procedure where a damaged or worn-out hip joint is replaced with an artificial joint, particularly for patients with hip osteoarthritis. This operation, widely regarded as the “operation of the century,” is noted for its profound impact on pain reduction and the enhancement of patients’ quality of life []. Before the operation, patients usually have questions concerning the procedure and the physical rehabilitation process [,].

The process of information delivery is highly important and represents a central pillar of patient education and the reduction of fear and anxiety [,]. Preoperative anxiety is a common experience among patients, often stemming from inadequate information about the surgical process. Therefore, patient education is of critical importance prior to surgery. Evidence supports that better-prepared patients—those who receive thorough preoperative education and physical conditioning—exhibit improved postoperative outcomes, including accelerated recovery and reduced complications. Therefore, enhanced patient education is an important component of surgical care [].

This is the first study to investigate surgical informed consent consultation using AI chatbots prior to THA. Here, we analyzed ChatGPT’s responses to patients’ posed questions preceding THA to assess its potential in preoperative patient education. Beyond the immediate benefits of patient education, the study explores the quality of the responses and potential hallucinations outputted by ChatGPT and systematically scrutinizes the system’s current ability to deliver adequate responses. This study also examines patients’ attitudes toward the use of an AI chatbot in a preoperative setting, along with potential cofactors influencing these attitudes. Assessing patient satisfaction with AI-driven consultations offers valuable insights into the acceptance and effectiveness of AI in patient interactions. The findings can inform the design of improved systems and the development of guidelines and protocols for integrating AI into patient care, particularly in sensitive areas like surgical informed consent.

Research questions:

1. What are patients’ preferences regarding the use of an AI chatbot in conjunction with a physician in surgical informed consent, in comparison to a physician only?
2. How does patient satisfaction compare across informed consent procedures involving only a physician, a physician and ChatGPT, or a physician and RAG-integrated ChatGPT?
3. How does the integration of RAG with ChatGPT improve the quality of responses to patients’ questions compared with the native ChatGPT model?
4. How do patient sociodemographic characteristics and general attitude toward AI influence patients’ preference toward using an AI chatbot in surgical informed consent?

Methods

ChatGPT

In this study, we used the OpenAI ChatGPT version 4o (May 13, 2024). To ensure consistency, all questions were presented to ChatGPT in a single, continuous chat session (per patient). The questions were asked by patients during their preoperative surgical consultation before THA in our clinical practice. For the purposes of the study, all patient queries were transcribed verbatim by the doctor into the ChatGPT interface.

In our study, we have used ChatGPT in two ways: (1) without any customization (native) and (2) with customization via RAG, described further below. The second approach allowed ChatGPT to access and incorporate subject-specific knowledge and thus potentially enhance the relevancy and accuracy of its responses. The performance and output accuracy of the 2 systems were compared as described below.

No patient-specific data was entered. The study was conducted in Germany, with all interactions and materials presented exclusively in German.

Recruitment

Patients scheduled for elective, primary THA were recruited from the orthopedic outpatient clinic or on the day of the information session. The study was conducted from May to July 2024. The consent consultations were conducted by 2 physicians who were pretrained based on the prepared frequently asked questions (FAQ) documentation.

Inclusion Criteria:

1. Age: Participants older than 18 years.
2. Diagnosis: Diagnosed with primary hip arthritis.
3. Treatment History: Currently indicated for primary hip arthroplasty.
4. Language: Able to read, understand, and complete study-related questionnaires in German.

Exclusion Criteria:

1. Cognitive impairment: Any cognitive impairment or psychiatric condition that would hinder the participant’s ability to provide informed consent and comply with study procedures.
2. Prior operation: History of primary or revision arthroplasty on the contralateral side.

The participants were provided with detailed written information about the aim of the study, the study procedure, the inclusion and exclusion criteria, and the informed consent about their participation in the study. The participants had the opportunity to ask questions about any aspect of the information provided, the questionnaires, and the study procedure.

Study Arms

Each patient was assigned to one of the following study arms:

1. Control group (human only): A physician conducting an informed consent consultation in a traditional face-to-face setting.
2. Intervention group I (native ChatGPT): ChatGPT was used in the questions and answers (Q&A) session in the presence of a physician.
3. Intervention group II (ChatGPT+RAG): ChatGPT+RAG was used in the Q&A session in the presence of a physician.

From the total population of 36 patients, the first 12 patients were assigned to the Control Group. The next 12 patients were included in the native ChatGPT group, and the final 12 patients were allocated to the ChatGPT+RAG group. All 36 patients enrolled in the study completed the full informed consent procedure and associated assessments, with no dropouts or exclusions.

In the RAG group, an extensive internal document containing all the information about the surgical procedure and the perioperative management at our hospital was compiled and integrated into ChatGPT via the RAG approach. This integration was achieved through the GPT app Keymate.AI (Keymate AI, Inc), which adds the information from the document into the model’s context window, effectively functioning as short-term memory. In the intervention group I, we added the following prompt text: “Please provide responses only in German and in the style of a medical doctor” (Bitte antworte nur in deutscher Sprache und im Stil einer Ärztin oder eines Arztes). In the intervention group II, we added a prompt text prior to each question posed to the AI chatbot: “Please provide responses only in German and in the style of a medical doctor. Please draw only on our internal FAQ document when responding” (Bitte antworte nur in deutscher Sprache und im Stil einer Ärztin oder eines Arztes. Bitte nutze zur Beantwortung ausschließlich die Informationen, die in unserem internen FAQ-Dokument enthalten sind). This setup is supposed to ensure that the AI chatbot responds preferably to the specific clinical information provided.

Data Collection Methods

Patient Sociodemographic Questionnaire and Class-Index

We collected the following patients’ characteristics: age, gender, and highest level of education.

Patients’ Preferences and Satisfaction Questionnaire

Data were collected using a self-constructed questionnaire that included 5 questions on a 7-point Likert scale regarding the preference of a physician in the informed consent procedure, the level of satisfaction with informedness, the procedure of information transfer, the quantity of information, as well as the preference for having a physician even with less information. Patients could also express their need for more information (yes/no).

Health Literacy Test for Total Hip Arthroplasty

To ensure that patients were capable of giving informed consent and could, in principle, understand the outputs of the AI chatbots, patients’ health literacy was measured with a questionnaire consisting of 9 multiple-choice questions. This questionnaire was adapted from a questionnaire for total knee arthroplasty [], but with knee information and questions replaced by those for hip arthroplasty.

The General Attitudes Towards Artificial Intelligence Scale

The General Attitudes towards Artificial Intelligence Scale (GAAIS) introduced by Schepman and Rodway [] was evaluated to assess patients’ attitudes toward AI. This 20-question scale is divided into a positive (12 questions) and a negative (8 questions) subscale. Both subscales capture emotions in line with their value. The 5-item scale ranges from 1 to 5. The mean of the positive questions constitutes the overall score for the positive subscale, while the same approach is applied to calculate the overall score for the negative subscale. The higher the score, the more positive the attitude toward AI. An overall scale mean was not recommended.

State-Trait Anxiety Inventory

To assess the actual state of anxiety (influenced by the current situation) and trait anxiety (the general anxiety of the patient), the Spielberger State-Trait Anxiety Inventory [] was administered, specifically Grimm’s abbreviated, validated version [].

Output Evaluation of AI Chatbot Responses

To assess the quality of the AI chatbot responses, we conducted a detailed evaluation of the questions asked by patients during their interactions with the AI chatbot and the model’s responses.

First, ChatGPT’s output was evaluated based on Magruder et al [] for relevance, accuracy, clarity, completeness, and evidence-based. Each criterion ranges from 1 to 5, with 5 being the best answer. We did not rate consistency between questions since every question was posed only once to the AI chatbot. For the accuracy criterion, we compared the responses with the official guideline on indication criteria for total hip arthritis of the “German Society for Orthopedics and Trauma” [], the FAQs of the German Arthroplasty Association [], and our internal standard operating procedures. To evaluate the length of ChatGPT’s output, we introduced an additional criterion that holds the balance between succinctness and informativeness. This criterion focused on whether the response was appropriately concise while fully addressing the question without unnecessary elaboration. Scores ranged from 1 (overly brief or excessively long, missing necessary information, or including redundant content) to 5 (ideal length, providing a complete and focused answer that matched the question).

Second, we evaluated the level to which the AI chatbot produced so-called hallucinations, that is, “content that is either nonsensical or unfaithful to the provided source content” [,]. ChatGPT’s output was classified as fully correct, partly hallucinated, and fully hallucinated. In addition, we annotated the level of hallucination using 3 degrees, following Rawte [] and adapted for the evaluation of AI chatbot outputs in the medical field. The degrees are mild, moderate, and alarming, with mild indicating minor hallucination that is superficial in terms of its impact, moderate indicating a level of hallucination that introduces facts that are either fictitious or tangential to the topic at hand and which could cause the patient to become confused or feel insecure, and alarming indicating added information pieces that bear a radical dissemblance from the topic fed via the prompt or which could lead to serious harm to the patient.

We have added all questionnaires used for data collection as (study questionnaires).

Procedure

The study procedure and timing of data collection were identical for the control group and the 2 intervention groups up to time point 3, as follows (summarized in below).

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• Baseline data collection (time point 1): Initial data were collected prior to the informed consent procedure.
• Information sheet (time point 2): After the patient had read the provided informed consent form.
• Physician explanation (time point 3): After the physician explained the operation, associated risks, and possible complications, using the information consent form as a reference. At this point in time, no questions were answered.

From time point 4 onward, the procedures diverged as follows.

• Control group (time point 4): After patients asked questions in a conventional face-to-face setting, the physician answered without AI chatbot assistance.
• Intervention groups I and II (time point 4): After patients’ questions were entered by the physician into the AI chatbot interface, and responses were read out word-for-word in German.

All hallucinated or incorrect responses were identified by the experienced physicians who were present throughout the informed consent consultations. These were explicitly addressed and corrected during the final stage of the session (time point 5), prior to concluding the informed consent process, thereby ensuring patient safety and upholding the integrity of the consultation. In other words, the final data collection step for the Control Group was time point 4, whereas the Intervention Groups had a fifth data collection step, time point 5.

This structured process ensured that all patients, regardless of their group, received clear and sufficient answers to their questions during the informed consent procedure. All Q&A of each information session were documented. All admission examinations were conducted in a standardized setting by the same orthopedic resident and were supervised by a senior orthopedic surgeon. In the following , the course of the survey, the times of data collection, and the method are shown.

The Patients’ Preferences and Satisfaction Questionnaire (PPSQ) was completed 5 times (4 times in the human-only group) during the informed consent procedure. The GAAIS was completed at the beginning and the end of the informed consent procedure to evaluate if a change in the overall inclination toward AI has occurred during the process. The sociodemographic questionnaire, State-Trait Anxiety Inventory, and Health Literacy Test (HLT) were completed prior to the informed consent procedure.

Statistical Methods

Sample Size Assumptions

In our exploratory pilot study, which was designed to generate initial insights and hypotheses for future, larger-scale investigations, a sample size of 12 participants per group (one control group and 2 intervention groups) was chosen based on the recommendations by Julious [].

Data Analysis

Statistical analyses were performed using SPSS Statistics (version 29; IBM Corp).

The Shapiro-Wilk test was applied to assess the normality of the data distribution for continuous variables. The test revealed that none of the collected data were normally distributed (P<.05). As a result, a nonparametric statistical test was used for all analyses.

A Friedman test was conducted to analyze differences in patients’ preferences and satisfaction levels (PPSQ) across the 5 time points: at the beginning of informed consent, after reading the information sheet, after consulting the physician, after using ChatGPT, and at the end of the informed consent process. For multiple pairwise comparisons following the Friedman test, a Bonferroni correction was applied.

The Wilcoxon signed-rank test was applied to evaluate dependent pairwise differences between satisfaction levels before and after the use of an AI chatbot. The same test measured differences between the GAAIS pre- and postinformed consent.

Spearman-Rho was used to analyze the correlation between GAAIS, State, Trait, and PPSQs.

The Mann-Whitney U test was used to compare independent differences between groups in the sociodemographic factors, the number of questions asked by participants, the number of questions including hallucinations, and the quality of the outputs of native ChatGPT and ChatGPT+RAG.

The Kruskal-Wallis test was used to analyze the effects of the highest educational attainment on the outcomes of the patients’ preferences and satisfaction levels (PPSQ; ie, across the 7 independent variables).

Patient questions were categorized into 5 predefined groups: operation, postoperative, complication, rehabilitation, and daily life. For the analysis, patient questions from the 2 intervention groups, the native and the ChatGPT+RAG group, were distributed across these categories. The number of questions within each category was counted for both groups. The Fisher-Freeman-Halton test was used to establish significance in differences in the categorical data. Cramer V was used for the calculation of effect size for Fisher-Freeman-Halton test; Friedmans effect size was calculated via Kendall ω, r was used for effect size of Mann-Whitney U test, and Wilcoxon signed-rank test after the following formula:

To assess interrater reliability between the investigators in assessing the AI-generated responses, Cohen κ coefficient was calculated. κ Statistic values were interpreted using the Landis and Koch criteria with values of 0.00 to 0.20 indicating slight agreement, 0.21 to 0.40 indicating fair agreement, 0.41 to 0.60 indicating moderate agreement, 0.61 to 0.80 indicating substantial agreement, and values of more than 0.80 indicating almost perfect agreement [].

Ethical Considerations

Approval for this prospective study was granted by the institutional review board of Charité – Universitätsmedizin Berlin (application number EA1/152/24). Informed consent was obtained from all participants prior to their inclusion in the study. No waiver of consent was requested or applied. All data collected for this study were pseudonymized prior to analysis. No personally identifiable information was included in the data. Participants did not receive any financial or material compensation for their involvement in the study. No images or supplementary materials used in this manuscript contain identifiable information of individual participants. Therefore, no additional image consent documentation was required or submitted.

Results

Demographic Data

provides an overview of the sociodemographic characteristics of the study participants.

Patients’ Preferences and Satisfaction Levels (PPSQ)

Need for a Human Doctor in the Informed Consent Consultation

Average results ranging between 5.50 and 6.65. Although slight shifts in patients’ expressed need were observed during the time points of the study procedure (), these changes were not statistically significant. Difference of preference during time points (t) in the 3 groups: human only (P=.85, χ²₃=0.818, ω=0.227); native ChatGPT (P=.28, χ²₄=5.127, ω=0.107); ChatGPT+RAG (P=.048, χ²₄=9.6, ω=0.200), with pairwise comparisons showing no differences across all groups.

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Satisfaction With the Process of Information Delivery

A difference in satisfaction levels was observed between the ChatGPT+RAG group and the native ChatGPT group (). In the ChatGPT+RAG group, the patients were more satisfied with the process of information delivery after interacting with the AI chatbot (P=.014, Z=–2.460, r=0.710). Patients’ satisfaction with the process of information delivery in the native ChatGPT group does not differ after using an AI chatbot compared with after the physician explained the THA operation procedure (P=.28, Z=–1.089, r=0.314).

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How Satisfied Are You With Your Perceived Level of Informedness?

A difference in satisfaction levels was observed between the ChatGPT+RAG group and the native ChatGPT group (). In the ChatGPT+RAG group, the patients were more satisfied with their level of informedness after interacting with the chatbot (P=.007, Z=–2.714, r=0.783). Patients’ satisfaction with the level of informedness in the native ChatGPT group does not differ after using the AI chatbot compared with after the physician explained the THA operation procedure (P=.06, Z=–1.890, r=0.546).

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Satisfaction With the Amount of Information Received

A difference in satisfaction levels with the quantity of information received was observed between the ChatGPT+RAG group and the native ChatGPT group (). In the ChatGPT+RAG group, the patients were more satisfied with the level of information received after interacting with the AI chatbot (P=.02, Z=–2.310, r=0.667). Patients’ satisfaction levels in the native ChatGPT group do not differ after using the AI chatbot compared with after the physician explained the THA operation procedure (P=.32, Z=–1.000, r=0.289).

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Preference for a Human Doctor Versus AI Chatbot

Results show that across all groups, participants preferred Scenario A (a human doctor with less accurate information) over Scenario B (an AI assistant alone with more accurate information). This preference was reflected in mean ratings ranging from 1.25 to 1.42 in the human-only group, 1.75 to 2.33 in the native ChatGPT group, and 0.58 to 0.83 in the ChatGPT+RAG group (). The preferred scenario did not change during the procedure of informed consent (human only: P=.75, χ²₃=1.200, ω=0.033; native ChatGPT: P=.78, χ²₄=1.775, ωs=0.037; ChatGPT+RAG: P=.68, χ²₃=1.500, ω=0.031).

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State-Trait Anxiety Inventory

The mean state anxiety among participants was 39.0% (SD 17.6%), with values ranging from 0% to 65.7%. The mean trait anxiety among participants was 28.9% (SD 14.4%), with values ranging from 0% to 61.4%. There was no correlation between State, Trait, and the preference of a physician in the informed consent procedure (p_state=0.158; p_trait=0.302), the level of satisfaction of informedness (p_state=0.522; p_trait=0.605), the procedure of information transfer (p_state=0.856; p_trait=0.822), the quantity of information (p_state=0.566; p_trait=0.330) as well as the preference for having a physician even with less information (p_state=0.087; p_trait=0.172).

Sociodemographic Factors’ Impact on PPSQ Values

Regarding age, participants were divided into 2 groups (younger vs older; with 55% in the older group above the mean age of 63.16 years). A statistically significant difference was observed for satisfaction with the process of information delivery, with older participants reporting higher scores (U=99.00, Z=–1.991, P=.046, r=0.332). For all other items, no significant age-related differences were found: need for a human doctor in the informed consent consultation (U=140.00, Z=–0.703, P=.48), satisfaction level of informedness (U=133.50, Z=–0.864, P=.39), satisfaction with the amount of information (U=110.00, Z=–1.622, P=.11), and preference for a human doctor versus AI chatbot (U=147.50, Z=–0.411, P=.68).

For gender, a statistically significant difference was identified for satisfaction with the amount of information, with female participants reporting higher satisfaction than males (U=81.00, Z=–2.299, P=.02, r=0.383). No significant differences were found for need for a human doctor in the informed consent consultation (U=123.00, Z=–0.964, P=.34), satisfaction with the process of information delivery (U=98.50, Z=–1.722, P=.09), satisfaction level of informedness (U=100.50, Z=–1.652, P=.10), or preference for a human doctor versus AI chatbot (U=143.00, Z=–0.221, P=.83).

Analyses of educational level showed no statistically significant differences for any of the Likert items: need for a human doctor in the informed consent consultation (H=4.472, df=3, P=.22), satisfaction with the process of information delivery (H=2.538, df=3, P=.47), satisfaction level of informedness (H=1.018, df=3, P=.80), satisfaction with the amount of information (H=2.730, df=3, P=.44), and preference for a human doctor versus AI chatbot (H=5.823, df=3, P=.12).

Health Literacy Impact on PPSQ Values

The HLT had a mean of 7.92 (SD 1.1) right answered questions, with a range from 6 to 9 right answers. No significant effects were identified related to the patients’ HLT outcomes. Analyses of HLT showed no statistically significant differences for any of the PPSQs: need for a human doctor in the informed consent consultation (H=2.435, df=3, P=.49), satisfaction with the process of information delivery (H=0.882, df=3, P=.83), satisfaction level of informedness (H=2.476, df=3, P=.48), satisfaction with the amount of information (H=2.919, df=3, P=.40), and preference for a human doctor versus AI chatbot (H=4.207, df=3, P=.24) with the patient’s highest level of education.

The GAAIS

Patients’ attitude towards AI did not change after using the AI chatbot in the informed consent consultation, despite GAAIS being negative in the native ChatGPT group (P=.02, Z=–2251, r=0.650; and ).

Significant correlation was shown between GAAIS positive and preference of a physician in the informed consent procedure (P=.002; ρ=0.502; ) and between GAAIS negative and preference of a physician in the informed consent procedure (P=.002; ρ=0.500; ).

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Patient Questions and AI Chatbot Responses

Examining the number of questions asked per group (), the control group stood out with fewer questions, totaling only 20, compared with the RAG group, which asked 52 questions (P=.002, U=20.50, Z=–3.042, r=0.621). The native ChatGPT group asked 39 questions, which were not statistically significant compared with the human-only group (P=.056, U=40.00, Z=–1.910, r=0.390). Additionally, no difference was observed between the RAG and native ChatGPT groups (P=0.22, U=51.00, Z=–1.228, r=0.251).

The average length of responses was measured for both intervention groups. In the native ChatGPT group, responses averaged 283.1 words and 2163.6 characters, while in the ChatGPT+RAG group, responses averaged 91.4 words and 689.8 characters (). This represents a ratio of 3.098 for word count (P<.001, U=81.00, Z=–7.483, r=0.784) and 3.136 for character count (P<.001, U=84.00, Z=–7.458, r=0.781), indicating that native ChatGPT-generated outputs are approximately 3 times longer than ChatGPT + RAG.

shows that in both the native ChatGPT and ChatGPT+RAG groups, most patient questions were focused on the operation itself, followed by questions related to postoperative management. Fewer questions were asked about rehabilitation, daily life, and complications. No differences were observed between the 2 groups in the distribution of question classifications (P=.35, V=0.226).

Evaluation of the ChatGPT Output Quality

Altogether, 91 questions were prompted, and the output was evaluated. shows the results of physicians’ evaluation of the ChatGPT outputs for every category (relevance, accuracy, clarity, completeness, evidence-based, and the length of the output). ChatGPT+RAG had better outcomes in every category compared with native ChatGPT (P<.001; relevance: r=0.504, U=2110.00, Z=–6.803; accuracy: r=0.365, U=2503.50, Z=–4.920; clarity: r=0.565, U=1722.00, Z=–7.629; completeness: r=0.479, U=1977.50, Z=–6.463; evidence-based: r=0.483, U=2082.00, Z=–6.517; length: r=0.726, U=1168.00, Z=–9.795). The minimum value for ChatGPT+RAG was 4.625, while its maximum value was 4.961. The minimum value for native ChatGPT was 3.346, while its maximum value was 4.115. Across all outputs, the κ is 0.761 (SE=0.032, z=22.705, P<.001), indicating a substantial level of agreement.

We observed significantly fewer hallucinations in the RAG group versus in the native ChatGPT group (5 out of 52 [10%] vs 15 out of 39, 38%; ). For 4 out of the 5 hallucinated responses in the ChatGPT+RAG group, no information was available in the FAQ documentation provided to ChatGPT via RAG from which the AI chatbot could draw.

ChatGPT+RAG has a significantly lower hallucination score compared with native ChatGPT (P=.002, U=729.00, Z=–3.168, r=0.332). The degree of severity shows no significant difference (P=.17, U=21.50, Z=–1.521, r=0.340).

– show examples of mild, moderate, and alarming hallucinations identified in our study.

Discussion

Overview

The results of this study provide several insights into the potential use of AI chatbots like ChatGPT in health care, particularly in enhancing patient education during the surgical informed consent consultation procedure.

Answers to Research Questions

What Are Patients’ Preferences Regarding the Use of an AI Chatbot in Conjunction With a Physician in Surgical Informed Consent in Comparison to a Physician Only?

Study results showed a clear expressed need for a human doctor in the informed consent procedure. No shifts in patients’ expressed needs were observed during the study procedure. Results also show a preference for scenario A (a human doctor only with worse information-delivery) versus scenario B (an AI-assistant only, with better information-delivery). The preferred scenario (ie, scenario A) did not change during the procedure of informed consent. However, the preference strength in each group differed at t value of 1 from 0.83 in the ChatGPT+RAG group to 1.83 in the native ChatGPT group with 1 being a slight preference for scenario A and 2 being a moderate preference for scenario A. The data presented suggest that patients would prefer the presence of a physician during the informed consent procedure. However, their preference for a human-only scenario (scenario A) over an AI chatbot-only scenario (scenario B) was only slight to moderate. This finding proposes the potential and additional benefit of patients’ interaction with AI chatbots.

In our study, state and trait anxiety exhibited no explanatory power for patients’ attitudes toward the necessity of a human doctor in the informed consent consultation, as well as their preference for a human doctor over an AI chatbot. In contrast, the general attitude towards AI (GAAIS) showed significant correlation with their preference toward interaction with AI during informed consent. One would assume that patients experiencing higher levels of anxiety may perceive AI-driven informed consent as less reliable compared with direct human interaction, potentially due to a need for empathetic communication. While it may be due to a lack of power with 36 patients, further research is necessary.

Li et al [] explored the concerns surrounding the integration of AI into health care from both patient and physician perspectives. Key concerns are “algorithm aversion,” robophobia, loss of humanistic care, and interaction challenges. Patients are particularly concerned about trust, privacy, and AI’s ability to deal with rare conditions or individual circumstances. Physicians, on the other hand, are concerned about job security, legal liability, and the emotional toll of introducing AI technologies into their work environment. The authors emphasize the importance of fostering trust, improving AI-human interaction, and providing appropriate education and policy frameworks to mitigate these concerns.

Emotional states of patients, such as anxiety toward AI, should be specifically addressed when implementing AI systems in sensitive areas like informed consent.

Providing additional support, such as hybrid models combining AI with physician oversight, could help alleviate patient concerns and improve acceptance, particularly in patients with higher levels of anxiety.

How Does Patient Satisfaction Compare Across Informed Consent Procedures Involving Only a Physician, a Physician and ChatGPT, or a Physician and RAG-Integrated ChatGPT?

After the Q&A sessions, all groups are similarly satisfied with their respective level of informedness and the quantity of information they received. This means that the Q&A with the AI chatbot was able to satisfy the information needs of the patients similarly well compared with the physician answering questions. In the ChatGPT+RAG group, the AI-assistant was able to close the previously existing gaps in both the level of informedness and the quantity of information they received after the FAQ session.

In the ChatGPT+RAG group, the patients were more satisfied with the process of information delivery after the Q&A session compared with the human-only and native ChatGPT groups, which may be due to the quality of responses observed with that approach (discussed below). The physicians involved in the study also reported that the more concise responses in the ChatGPT+RAG group were seen as very positive by the patients.

The improved satisfaction in the RAG group may be attributed to the more context-specific and evidence-based responses generated by the RAG-enhanced system. These findings are consistent with prior research indicating that the RAG approach improves output quality, increases patient confidence, and understanding during medical consultations in patient-AI chatbot interaction [-]. By tailoring responses to individual questions and incorporating subject- and clinic-specific data, the RAG approach appears to address key patient concerns more effectively than the native ChatGPT model.

One of the most striking findings was that the control group, which did not interact with the AI chatbot, asked the fewest questions (n=20), whereas the ChatGPT group asked more (n=39), and the RAG group asked the most questions (n=52). The higher number of questions observed in the AI-supported groups may reflect differences in interaction dynamics rather than a lack of clarity, relevance, quality, or completeness in the responses, which were all rated as good to very good, particularly in the ChatGPT+RAG group (). Patients may have felt more comfortable, autonomous, or curious when interacting with the AI chatbot, especially in the ChatGPT+RAG group, where responses tended to be more concise and focused. This may have encouraged additional follow-up questions and deeper engagement with the content. A general indication of these results is therefore that patients in informed consent procedures can benefit from multimedia decision aids and tools such as ChatGPT that may help to encourage engagement and improve patient understanding [].

How Does the Integration of RAG With ChatGPT Improve the Quality of Responses to Patients’ Questions Compared With the Native ChatGPT Model?

The results clearly demonstrate the advantages of the RAG approach over native ChatGPT in all measured quality dimensions. Responses generated with ChatGPT+RAG consistently scored higher in relevance, accuracy, clarity, completeness, evidence-based, and length compared with those generated by the native ChatGPT model (). This demonstrates the effectiveness of incorporating domain-specific information into AI chatbot responses to ensure better alignment with patient needs.

ChatGPT+RAG responses were significantly more concise than native ChatGPT responses, which tended to be much longer and more detailed. While detailed responses may seem advantageous, overly long responses run the risk of overwhelming patients and diluting the focus on their specific questions. In contrast, the concise responses of ChatGPT+RAG were likely perceived as clearer and more directly relevant, contributing to the higher quality ratings observed.

The use of RAG significantly reduced hallucinations in our study. In 4 out of 5 cases in which the AI chatbot hallucinated in the ChatGPT+RAG group, hallucinations were due to missing information in the FAQ document provided as information to the AI chatbot. This might suggest that when properly designed and managed, AI chatbots can provide responses with very few hallucinations. Other studies confirmed the effectiveness of a RAG approach für medical AI chatbots [-,,]. The low error rate obtainable through RAG in conjunction with as complete as possible and guideline-compliant FAQ documentation, together with the high consistency of an AI chatbot, can therefore lead to very good results in combination with a human in medical education. Furthermore, the minimal hallucinations observed in the ChatGPT+RAG group provided valuable insights, enabling improvements to our internal FAQ documentation following the study.

While our study did not explicitly measure consistency across identical or similar prompts, we observed qualitative indications that ChatGPT combined with RAG exhibited higher consistency in its responses. For instance, in the native ChatGPT condition, answers to similar questions regarding the expected length of hospital stay varied, once stating “3-7 days” and another time “5-10 days.” In contrast, the RAG-enhanced version consistently responded with “4-7 days,” which aligns precisely with the information provided in the underlying FAQ documentation. This suggests that the integration of a structured reference source via RAG can improve both accuracy and consistency. However, due to the limited number of participants and the small number of semantically similar questions per group, we were not able to systematically evaluate consistency in this study.

The results show the value of the RAG approach optimizing AI chatbots for use case-specific and clinic-specific information, particularly in sensitive processes like surgical informed consent consultations, where correct, clear, and comprehensive communication is essential. However, it is important to continuously monitor these tools to ensure patient safety in all cases. Furthermore, more research is needed with different datasets provided to the AI chatbot via the RAG approach, different AI-language models, different RAG-architectures, different prompts, and with more patients.

How do Patient Sociodemographic Characteristics and General Attitude Toward AI Influence Patients’ Preference Toward Using an AI Chatbot in Surgical Informed Consent?

Our results show that age, gender, and education did not influence patients’ preference toward using an AI chatbot in surgical informed consent. There is no clear consensus as per today in the body of literature about the role of age in AI or technology acceptance. Witkowski et al [] found that age is associated with AI discomfort in health care. Miller et al [], who studied patients’ use and perception of an AI-based symptom assessment and advice technology in a British primary care waiting room, identified several age-related trends among respondents, with a directional trend for more young respondents (18- to 24-year-olds) to report that the tool provided helpful advice than older respondents (adults older than 70 years). Other studies show that older people are not per se “anti-tech” or “anti-AI.” Xiang et al [] found that receptivity to medical AI increases with age, reaching its highest levels among individuals aged 49 years and older. More research is required in different age groups and medical domains, for example, in arthroscopy, where patients are usually younger.

Patients’ general attitudes toward AI demonstrated weak explanatory power for patients’ preference regarding the necessity of a doctor in the informed consent process and their preference for a human doctor over an AI chatbot. However, further research is needed to better understand the impact of attitudes toward AI. The general attitude of patients toward AI could be considered in the design of processes and systems in the future. This is also against the background that AI and systems that integrate AI are developing rapidly, and their implementation in interaction with patients and doctors must therefore be continuously examined.

The results of the present study demonstrate that, although the analysis of native ChatGPT outputs shows significantly worse performance compared with ChatGPT+RAG, patients report high satisfaction with the process of information delivery, their perceived level of informedness, and the amount of information received across all 3 groups. This should be considered in the design of AI-driven patient interactions. Despite the suboptimal quality of native ChatGPT responses as evaluated by physicians, the RAG approach showed significantly better performance, including higher patient engagement and markedly fewer hallucinations, making it a more promising option for precise patient information delivery.

However, given that patients prefer the presence of a physician and that the RAG approach cannot eliminate hallucinations, we strongly recommend using RAG-based AI chatbots, but only in combination with a physician. Ensuring that patients are not left alone in the information process is crucial. RAG chatbots, meanwhile, offer a complementary solution for enhancing patient communication and reducing the time burden on physicians in daily practice. The additional time gained can help address issues related to patient education, literacy barriers, language differences, and limited doctor communication skills (eg, offering an easy-language mode).

Future Research Direction

The findings of this study suggest several potential directions for future research to better understand patient preferences and concerns regarding AI chatbots in health care, as well as to explore their possible applications in patient care. As we observed more questions in the AI-assisted groups, these tools may help enhance patient engagement. However, the underlying interaction dynamics as well as the number, type, and nature of follow-up questions should be explored in future research.

Since the RAG approach has proven to have a significantly higher engagement and quality compared with the native ChatGPT version, it might be advisable to prioritize further investigation and to expand the approach by incorporating patient-specific input. Further investigation is needed to assess AI chatbots that could provide patient-tailored information and guidance during preoperative and postoperative care.

From a technological perspective, further work is needed to examine how different implementations, such as variations in the RAG framework or AI-language models, and variations in the type and structure of information provided to and by the AI chatbot, affect the results. Future studies should also explore patient interactions using different interfaces (eg, keyboards or voice assistants) and mobile apps of AI chatbots, particularly outside formal informed consent procedures.

The potential for these tools to be perceived as reliable and trustworthy by patients requires careful evaluation while adhering to the principles of patient-centered care []. Patients may also have concerns regarding data privacy and the ability of AI systems to handle rare or complex conditions. While this pilot study did not explore these dimensions in depth, such concerns are central to the responsible use of AI in health care and should be addressed in future research. Future research should integrate qualitative methods, such as interviews or free-text survey responses, to complement structured evaluations and capture deeper insights into patient trust, expectations, and experiences with AI.

Finally, demographic factors such as age, cultural background, and other sociodemographic variables need to be studied in greater detail to understand how different patient groups perceive and interact with AI chatbots. While AI has the potential to make health care more accessible, it is essential to ensure that these tools address the diverse needs of patients and do not inadvertently create new barriers to care.

Limitations

In our study, we aimed at covering a wide range of questions regarding the new field of patient AI chatbot interaction in the surgical informed consent procedure. Yet, our study is not without limitations.

First, the relatively small sample size (N=36) limits the statistical power and generalizability of the findings. However, this sample size was deliberately chosen, as the exploratory pilot study aimed at hypothesis generation and feasibility testing. Future research should expand the sample size to enable more robust subgroup analyses. Second, the over-representation of middle-aged and older adults in our sample may limit the applicability of findings to younger patient populations. While we addressed age-related aspects through subgroup analysis using commonly applied age categories in health care and HCI literature, future studies should aim to recruit more age-diverse cohorts to better understand age differences in trust, comprehension, and preferences regarding AI-assisted consent formats. Third, a physician was present during all informed consent consultations across all study groups. This ensured ethical oversight and patient safety, particularly in the AI-assisted scenarios, but may have influenced patient behavior and interaction with the chatbot. Patients might have perceived the chatbot as being supervised or endorsed by the physician. Future studies should explore different formats and levels of physician involvement to better isolate the effects of AI guidance.

To address these limitations and build on our findings, future studies should involve larger and more demographically diverse samples, test a range of physician-AI interaction models, and include qualitative measures. Moreover, replication in varied clinical settings will be essential to assess the generalizability and practical utility of AI chatbots in surgical informed consent consultations and other medical communication contexts.

Conclusions

This study is the first to explore the feasibility, response quality, and patient acceptance of AI-supported surgical informed consent consultations. By comparing traditional physician-led consultations with those assisted by ChatGPT and ChatGPT+RAG, we found that patient satisfaction remained consistently high across all groups, suggesting that the use of AI support did not compromise the informed consent experience. The integration of RAG significantly enhanced the quality of AI-generated responses and reduced hallucination rates compared with native ChatGPT. Notably, participants in the ChatGPT+RAG group reported the highest satisfaction with information delivery and perceived informedness, alongside greater engagement as reflected in the number of questions asked.

Although most patients still preferred physician-led consultations, our findings are encouraging. They indicate that AI chatbots, particularly when enhanced with clinical-specific information via RAG, can deliver accurate, context-aware, and concise information while promoting patient participation. Given the small sample size, future studies are needed to confirm these findings in more diverse populations and to examine the role of AI chatbots in different and more autonomous patient-AI interactions and across different clinical contexts. However, as we embrace this opportunity, it is essential to remain cautious about challenges such as trust, data privacy, and the preservation of the human touch in patient care.

NEWCASTLE & HOUSTON, October 22, 2025 — TechnipFMC plc (NYSE: FTI) today announced that its Board of Directors has authorized and declared a quarterly cash dividend of $0.05 per share, payable on December 3, 2025 to shareholders of record as of the close of business on the New York Stock Exchange on November 18, 2025, which is also the ex-dividend date.

The Board has also authorized additional share repurchases of up to $2 billion. Together with the remaining balance under the existing program, the Company is now authorized to repurchase shares of up to $2.3 billion, representing nearly 16 percent of the Company’s outstanding shares at the closing price on October 21, 2025. 

Doug Pferdehirt, TechnipFMC’s Chair and CEO, stated, “Since the initial share repurchase authorization in July 2022, the Company has returned more than $1.6 billion to shareholders through stock repurchases and dividends. This significant increase to the share authorization exemplifies our confidence in the outlook, as well as our commitment to maximize shareholder value.”

The Company expects to repurchase shares from time to time through open market purchases, privately negotiated transactions, Rule 10b5-1 plans, and any other means in accordance with applicable securities laws. The share repurchase program does not obligate the Company to repurchase shares and may be suspended or discontinued at any time at the Company’s discretion.

Important Information for Investors and Securityholders

Forward-Looking Statement

This release contains “forward-looking statements” as defined in Section 27A of the United States Securities Act of 1933, as amended, and Section 21E of the United States Securities Exchange Act of 1934, as amended. The words “expect,” “believe,” “estimated,” and other similar expressions are intended to identify forward-looking statements, which are generally not historical in nature. Such forward-looking statements involve significant risks, uncertainties and assumptions that could cause actual results to differ materially from our historical experience and our present expectations or projections. For information regarding known material factors that could cause actual results to differ from projected results, including our assumptions and projections regarding the announced share repurchase program, please see our risk factors set forth in our filings with the United States Securities and Exchange Commission, which include our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, and Current Reports on Form 8-K. We caution you not to place undue reliance on any forward-looking statements, which speak only as of the date hereof. We undertake no obligation to publicly update or revise any of our forward-looking statements after the date they are made, whether as a result of new information, future events or otherwise, except to the extent required by law.

 

###

About TechnipFMC

TechnipFMC is a leading technology provider to the traditional and new energy industries, delivering fully integrated projects, products, and services. 

With our proprietary technologies and comprehensive solutions, we are transforming our clients’ project economics, helping them unlock new possibilities to develop energy resources while reducing carbon intensity and supporting their energy transition ambitions. 

Organized in two business segments — Subsea and Surface Technologies — we will continue to advance the industry with our pioneering integrated ecosystems (such as iEPCI™, iFEED™ and iComplete™), technology leadership and digital innovation.

Each of our approximately 21,000 employees is driven by a commitment to our clients’ success, and a culture of strong execution, purposeful innovation, and challenging industry conventions.

TechnipFMC uses its website as a channel of distribution of material company information. To learn more about how we are driving change in the industry, go to www.TechnipFMC.com and follow us on X @TechnipFMC. 

Contacts

Investor relations
Matt Seinsheimer
Senior Vice President, Investor Relations and Corporate Development
Tel: +1 281 260 3665
Email: Matt Seinsheimer

James Davis
Director, Investor Relations
Tel: +1 281 260 3665
Email: James Davis

Media relations
Mendi Head
Public Relations and Media Relations
Tel: +1 346 297 8392
Email: Mendi Head 

MENLO PARK, Calif., Oct. 22, 2025 (GLOBE NEWSWIRE) — PacBio (NASDAQ: PACB) announced today that it will hold its quarterly conference call to discuss its third quarter 2025 financial results on Wednesday, November 5, 2025, at 4:30 pm Eastern Time.

The call will be webcast and may be accessed at PacBio’s website at https://investor.pacificbiosciences.com/.

Date: Wednesday, November 5, 2025, at 4:30 pm ET (1:30 pm PT)
Listen live via internet or replay: https://investor.pacificbiosciences.com/
Toll-free: 1-888-349-0136
International: 1-412-317-0459

If using the dial-in option, please join the call ten minutes before the start time using the appropriate number above and ask to join the “PacBio Q3 Earnings Call.”

About PacBio

PacBio (NASDAQ: PACB) is a premier life science technology company that designs, develops, and manufactures advanced sequencing solutions to help scientists and clinical researchers resolve genetically complex problems. Our products and technologies, which include our HiFi long-read sequencing, address solutions across a broad set of research applications including human germline sequencing, plant and animal sciences, infectious disease and microbiology, oncology, and other emerging applications. For more information, please visit www.pacb.com and follow @PacBio.

PacBio products are provided for Research Use Only. Not for use in diagnostic procedures.

Contacts

Investors:
Jim Gibson
ir@pacb.com

Media:
pr@pacb.com

Morning everyone. In good news for some and depressing news for others, house prices have risen at their fastest rate for four years boosted by interest rate cuts and the extension of the government’s first-home guarantee. In more money news, a Choice survey shows that rapid-delivery groceries are almost 40% more expensive.

Plus we look at Sussan Ley’s net zero dilemma, we have a maths challenge, and Australia’s women have walloped England by six wickets in the World Cup.

Australia

• Uber pricey | Shoppers are paying up to 39% more for groceries ordered through rapid delivery apps, according to a Choice survey, with items such as pasta, milk and fresh vegetables costing on average 11% more on third-party apps such as Uber Eats, DoorDash and Milkrun compared with supermarkets.

• ‘Acceleration mode’ | House prices are rising at their fastest rate in nearly four years, according to new research, as buyers rush to auctions and owners put off selling amid expectations of a further upswing. Brisbane has overtaken Canberra as the second-most expensive house market, after Sydney, with median prices rising nearly $40,000 to hit $1.1m.

• Ban challenged | Queensland’s controversial ban on puberty blockers and other hormone therapies is unlawful because of a failure to properly consult health executives on a decision affected by political interference, a court has heard.

• Keating cross | A development backed by media scion James Packer in Sydney’s Kings Cross is pitting the former prime minister Paul Keating against former NSW premier Morris Iemma.

• Plus points | If, like the Morning Mail, you were unable to help kids with maths after year 7, look away now. But for those of you who like a challenge, test yourself on yesterday’s tough NSW HSC maths paper.

World

• Exclusive | Prominent Jewish figures such as Naomi Klein, Jonathan Glazer and Wallace Shawn are calling on the United Nations and world leaders to impose sanctions on Israel over what they describe as “unconscionable” actions amounting to genocide in Gaza.

• Senate marathon | Jeff Merkley, Oregon’s Democratic senator, has given a marathon speech on the Senate floor lasting more than 19 hours to make the case that Donald Trump is acting as an authoritarian, including by deploying the military into his home city of Portland. Meanwhile, the US president declared himself the arbiter of whether or not his own administration should pay him hundreds of millions of dollars in damages over past federal investigations.

• Exclusive | A man sent back to France under Britain’s “one in, one out” scheme has returned to the UK on a small boat and claims to be a victim of modern slavery at the hands of trafficking gangs.

• Ukraine ‘compromise’ | Volodymyr Zelenskyy has voiced support for Donald Trump’s proposal for Ukraine and Russia to freeze the war at the current frontlines, calling it “a good compromise”.

• Quantum leap | Google has claimed a breakthrough in quantum computing after developing an algorithm that performed a task beyond the capabilities of conventional computers.

Full Story

Can Ange Postecoglou stage a comeback?

Sports writer Martin Pegan speaks to Reged Ahmad about Ange Postecoglou’s sacking by Nottingham Forest and what’s next for one of the most polarising figures in football.

Full Story

Can Ange Postecoglou stage a comeback?

In-depth

With a crunch Coalition meeting on net zero looming, Dan Jervis-Bardy examines the challenge facing Sussan Ley as she tries to formulate a one-size-fits-all policy. As Dan writes, “it is not hyperbole to suggest that this debate threatens to tear the Coalition apart”, with Barnaby Joyce potentially beginning a wave of defections.

Not the news

Squats, lateral flexions, wall sits and elevated incline push-ups are all exercises that you can do in your everyday clothes without interfering too much with your life. Our very own Emma Joyce gave them a try at Guardian Australia HQ. Find out she fared.

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Sport

• Cricket | Australia took up where they left off in the Ashes last summer by crushing England by six wickets in the penultimate group game of the Women’s World Cup in Indore thanks firstly to fine bowling by Alana King and brilliant batting by Annabel Sutherland and Ash Gardner.

• Football | Sam Kerr’s return to the Matildas squad for the forthcoming friendlies against Wales (midnight Sunday) and England (6am Wednesday) can’t come too soon for a team that has stalled in recent months. Eintracht Frankfurt will be hoping to extend Liverpool’s losing streak to five in this morning’s Champions League game, while there’s also a meeting of European royalty as Real Madrid host Juventus.

• Rugby league | The Leeds prop Mikolaj Oledzki moved from Poland 20 years ago and had no idea what rugby league was. Now he’s preparing to face Australia in the Ashes at Wembley.

Inner-city Melbourne suburbs must accept more housing development and can’t expect the west to keep doing the heavy lifting, Clare O’Neil said last night according to the Age. The Telegraph has picked up despairing social media reaction to yesterday’s HSC maths exam with one describing it as “actually impossible”. The Bureau of Meteorology’s redesigned website is dividing users with many calling for the old one to be reinstated, the Adelaide Advertiser reports.

What’s happening today

• New South Wales | The leader of the opposition, Mark Speakman, and shadow ministers will make a “major 2027 election policy announcement” in Sydney.

• Business | Star Entertainment holds its annual general meeting on the Gold Coast.

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Brain teaser

And finally, here are the Guardian’s crosswords to keep you entertained throughout the day. Until tomorrow.

Triple-negative breast cancer is one of the most aggressive cancers. The name tells the story: It lacks the three main targets that make other types of breast cancers more treatable with powerful therapies.

UCLA researchers have developed a novel therapy that could fundamentally change the treatment plan for this deadly disease. In a study published in the Journal of Hematology & Oncology, the team details how this new type of immunotherapy, called CAR-NKT cell therapy, could attack tumors from multiple fronts while dismantling their protective shields.

Patients with triple-negative breast cancer have been waiting far too long for better treatment options. To finally have a therapy that shows superior cancer-fighting ability – and to be just one step away from clinical testing – is incredibly exciting.”

Lili Yang, senior author, professor of microbiology, immunology and molecular genetics and member of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA

The therapy uses engineered immune cells called CAR-NKT cells, which can be mass-produced from donated blood stem cells and stored ready-to-use. This off-the-shelf approach offers an immediately available treatment option at a fraction of the cost of current personalized cell therapies, which can soar into the hundreds of thousands of dollars.

A triple threat against a triple-negative cancer

CAR-T cell therapies have transformed treatment for certain blood cancers by turning patients’ own immune cells into precision weapons. However, these therapies have struggled against solid tumors like breast cancer, which employ sophisticated defense mechanisms and constantly evolve to evade treatment.

To tackle these hurdles, the UCLA team’s cell therapy harnesses a rare but powerful type of immune cell called invariant natural killer T cell, or NKT cell. When equipped with a chimeric antigen receptor, or CAR, targeting mesothelin – a protein found on triple-negative breast cancer cells – these potent tumor-fighting cells gain the ability to recognize and destroy cancer through three distinct mechanisms.

The first mechanism uses the engineered CAR to target mesothelin, which is associated with more aggressive, metastatic disease. The second leverages the cells’ natural killer receptors that recognize more than 20 molecular markers, making it nearly impossible for tumors to evade all of them. The third employs the cells’ unique T cell receptor to reshape the tumor microenvironment by eliminating immunosuppressive cells.

“We’re not just targeting one molecular marker on cancer cells – we’re identifying dozens of them simultaneously,” said first author Yanruide (Charlie) Li, a postdoctoral scholar in the UCLA Broad Stem Cell Research Center Training Program. “It’s like attacking a fortress from every direction at once. The cancer simply can’t adapt fast enough to escape.”

When the research team tested the novel therapy on tumor samples from patients with late-stage metastatic breast cancer, the CAR-NKT cells successfully killed cancer cells in every single sample tested, while also eliminating the immunosuppressive cells that tumors recruit as protective escorts.

Engineering universal accessibility

Beyond its multipronged cancer-fighting capabilities, the CAR-NKT platform addresses critical barriers that have limited cell therapy access: manufacturing complexity and cost.

Current cellular immunotherapies require collecting each patient’s immune cells, shipping them to specialized laboratories for genetic modification, then returning the customized product into the patient weeks later – a process that can cost six figures and create dangerous delays for patients with aggressive cancers.

Yang’s team takes a fundamentally different approach. Because NKT cells naturally work with any immune system, they can be mass-produced from donated blood stem cells using a scalable system. A single donation could generate enough cells for thousands of treatments, reducing costs to approximately $5,000 per dose.

One product to tackle multiple cancers

The therapy’s promise extends beyond triple-negative breast cancer. Since mesothelin is also highly expressed in ovarian, pancreatic and lung cancers, the same cell product could potentially treat multiple cancer types that remain difficult to address with current immunotherapies.

“This is really a platform technology,” said Yang, who’s also a member of the UCLA Health Jonsson Comprehensive Cancer Center.

With all preclinical studies complete for both triple-negative breast cancer and ovarian cancer, the team is preparing to submit applications to the Food and Drug Administration to begin clinical trials.

“We’ve walked 99 steps to get here,” Yang said. “We’re missing just one final step to begin clinical testing and demonstrate what this promising therapy can really do for patients.”

Additional authors include: Xinyuan Shen, Yichen Zhu, Zhe Li, Ryan Hon, Yanxin Tian, Jie Huang, Annabel Zhao, Nathan Ma, Catherine Zhang, David Lin, Karine Sargsyan and Yuan Yuan.

The research was supported by the California Institute for Regenerative Medicine, the Department of Defense, the UCLA Broad Stem Cell Research Center, the Wendy Ablon Trust, the Parker Institute for Cancer Immunotherapy, UCLA’s department of microbiology, immunology and molecular genetics, the UCLA Office of the Chancellor and the UCLA Goodman-Luskin Microbiome Center. 

The Trump administration is considering a plan to curb a dizzying array of software-powered exports to China, from laptops to jet engines, to retaliate against Beijing’s latest round of rare earth export restrictions, according to a US official and three people briefed by US authorities.

While the plan is not the only option on the table, it would make good on Donald Trump’s threat earlier this month to bar “critical software” exports to China by restricting global shipments of items that contain US software or were produced using US software.

On 10 October, Trump said in a social media post that he would impose additional tariffs of 100% on China’s US-bound shipments, along with new export controls on “any and all critical software” by 1 November without further details. To be sure, the measure, details of which are being reported for the first time, may not move forward, the sources said.

But the fact that such controls are being considered shows the Trump administration is weighing a dramatic escalation of its showdown with China, even as some within the US government favor a gentler approach, according to two of the sources. US stock indexes briefly extended losses on the news, with the S&P 500 down 0.8% and the Nasdaq 1.3% lower before paring their losses.

The White House declined to comment. The commerce department, which oversees export controls, did not respond to requests for comment.

A spokesperson for the Chinese embassy did not comment on the specific US measures under consideration but said China opposed the US “imposing unilateral long-arm jurisdiction measures” and vowed to “take resolute measures to protect its legitimate rights and interests” if the US proceeds down what it views as a wrong path.

Administration officials could announce the measure to put pressure on China but stop short of implementing it, one of the sources said. Narrower policy proposals are also being discussed, two of the people said.

“Everything imaginable is made with US software,” one of the sources said, highlighting the broad scope of the proposed action. The sources declined to be named because the matter was not public.

The move could disrupt global trade with China, especially for technology products, and could come at a cost to the US economy if fully implemented.

The measure, if adopted, would echo restrictions that the Biden administration imposed on Moscow after its 2022 invasion of Ukraine. Those rules restricted exports to Russia of items made globally using US technology or software. Trump’s Truth Social post came just three weeks before a previously announced meeting with Xi Jinping, China’s president, in South Korea, and a day after China dramatically expanded its export controls on rare earth elements. China dominates the market for such elements, which are essential to tech manufacturing.

In his post, Trump said China’s action, also effective 1 November, represented “a moral disgrace” that would impose controls on “virtually every product they make”.

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But questions have swirled about what Trump meant in his response by “critical software” controls.

While Trump has slapped a series of tariffs on China since taking office in January, he has wavered in his use of export restrictions against Beijing, first imposing strict new curbs on shipments of Nvidia’s AI chips as well as chip design software to China, and later removing them.

China expressed its opposition to a Trump administration rule last month that restricts US companies from shipping goods and technology to companies at least 50% owned by sanctioned Chinese firms. Chinese imports currently face US tariffs around 55%, which could shoot up to 155% if Trump follows through on his threatened tariff hike. But Trump appeared to soften his posture on Beijing following the threats, posting on 12 October: “The U.S.A. wants to help China, not hurt it!!!”

Social media platform Reddit sued the artificial intelligence company Perplexity AI and three other entities on Wednesday, alleging their involvement in an “industrial-scale, unlawful” economy to “scrape” the comments of millions of Reddit users for commercial gain.

Reddit’s lawsuit in a New York federal court takes aim at San Francisco-based Perplexity, maker of an AI chatbot and “answer engine” that competes with Google, ChatGPT and others in online search.

Also named in the lawsuit are Lithuanian data-scraping company Oxylabs UAB, a web domain called AWMProxy that Reddit describes as a “former Russian botnet,” and Texas-based startup SerpApi.

It’s the second such lawsuit from Reddit since it sued another major AI company, Anthropic, in June.

But the lawsuit filed Wednesday is different in the way that it confronts not just an AI company but the lesser-known services the AI industry relies on to acquire online writings needed to train AI chatbots.

“Scrapers bypass technological protections to steal data, then sell it to clients hungry for training material. Reddit is a prime target because it’s one of the largest and most dynamic collections of human conversation ever created,” said Ben Lee, Reddit’s chief legal officer, in a statement Wednesday.

Perplexity said it has not yet received the lawsuit but “will always fight vigorously for users’ rights to freely and fairly access public knowledge. Our approach remains principled and responsible as we provide factual answers with accurate AI, and we will not tolerate threats against openness and the public interest.”

Oxylabs and SerpAPI didn’t immediately respond to requests for comment Wednesday. AWMProxy could not immediately be reached for comment.

Reddit compares the companies it is suing to “would-be bank robbers” who can’t get into the bank vault, so they break into the armored truck instead. The lawsuit alleges they are evading Reddit’s own anti-scraping measures while also ”circumventing Google’s controls and scraping Reddit content directly from Google’s search engine results.”

Lee said that because they’re unable to scrape Reddit directly, “they mask their identities, hide their locations, and disguise their web scrapers to steal Reddit content from Google Search. Perplexity is a willing customer of at least one of these scrapers, choosing to buy stolen data rather than enter into a lawful agreement with Reddit itself.”

Much like its lawsuit against Anthropic, maker of the chatbot Claude, Reddit claims that Perplexity has accessed Reddit’s content despite being asked not to do so.

Reddit made a similar argument in its lawsuit against Anthropic. That case was initially filed in California Superior Court but was later moved to federal court and has a hearing scheduled for January.

Along with digitized books and news articles, websites such as Wikipedia and Reddit are deep troves of written materials that can help teach an AI assistant the patterns of human language.

Reddit has previously entered licensing agreements with Google, OpenAI and other companies that are paying to be able to train their AI systems on the public commentary of Reddit’s more than 100 million daily users.

The licensing deals helped the 20-year-old online platform raise money ahead of its Wall Street debut as a publicly traded company last year.

Foley Hoag partner Brooke Fritz to join a panel discussion titled “Advocating for Your Business, Yourself, and Your Team” during MTLC’s Professional Women’s Meeting: Negotiation Techniques.

Find your full leadership potential at this meeting designed for women in tech and leadership roles. Negotiation is a critical tool for advancing your business objectives, championing your team, and advocating for yourself in every professional setting.

​You will hear from accomplished sales and tech leaders who are skilled in both business and personal negotiation. This event will equip you with actionable negotiation techniques and frameworks you can use immediately—no matter your role or title.

​What to expect:

• Practical negotiation tactics tailored for tech professionals
• ​Real-world scenarios and relatable stories from top women in sales
• ​Strategies for overcoming internal and external barriers to advocacy
• Tools for elevating your team, driving business outcomes, and maximizing your impact
• ​Networking with fellow women leaders committed to growth and empowerment