- Nvidia-backed CoreWeave’s shares fall as data center delay hits annual revenue forecast Reuters
- CoreWeave’s Earnings Will Be Tested as the AI Cloud Boom Becomes Real vocal.media
- CoreWeave Stock Slides on Q3 Results—Is a Rebound Ahead by 2026? Bitget
- CoreWeave boosts major AI partnerships as revenue surges in Q3 capacityglobal.com
- CoreWeave earnings: Data-center operator posts $56 billion in contracted future revenue, but revenue guidance drops Fortune
Category: 3. Business
-
Nvidia-backed CoreWeave's shares fall as data center delay hits annual revenue forecast – Reuters
-
Spotify and NMPA Announce Agreement to Expand Direct-Licensing Audiovisual Opportunities for Independent Publishers — Spotify
Today, Spotify and the National Music Publishers’ Association (NMPA) launched a new Opt-In Portal for NMPA members to enter into a direct license agreement for expanded audiovisual rights in the US. These new agreements mean higher royalty payouts for independent music publishers and songwriters, and in exchange Spotify will receive new rights to build video features that better connect artists and fans.
“This new partnership with the NMPA will increase revenue for songwriters and independent publishers who are the heart of the industry.” said Alex Norström, Co-President and Chief Business Officer, Spotify. “We look forward to continuing to work with the NMPA to create new value and opportunities for their members.”
“We are pleased that this deal offers indie publishers the chance to enter into direct deals with Spotify in regard to audiovisual streaming functionality on the platform alongside the recently announced larger publishing companies,” added David Israelite, President and CEO, NMPA. “This new income stream reflects the growing value of songs as digital platforms offer new capabilities to consumers.”
The NMPA Opt-In Portal is open to eligible publishers beginning today, November 11, 2025, with onboarding continuing through December 19.
Continue Reading
-
SNAPSHOT S&P 500, Nasdaq slip as tech valuation jitters resurface; federal reopening eyed – Reuters
- SNAPSHOT S&P 500, Nasdaq slip as tech valuation jitters resurface; federal reopening eyed Reuters
- Stocks rise as US shutdown nears end; niggles over tech persist Reuters
- Markets News, Nov. 10, 2025: Stocks Surge on Optimism for Deal to End US Government Shutdown; Palantir Leads Tech Rebound Investopedia
- Stocks rally, Treasury yields advance on hopes for a US government reopening By Reuters Investing.com
- Wall Street points lower before the opening bell as selling of AI shares weigh on sentiment Barchart.com
Continue Reading
-
Wind River and Hyundai Rotem Advance Industrial Rail Systems with a Modern Software Development Environment
Applying a Software-Defined Vehicle Approach to Accelerate the Future of Railway Innovation
ALAMEDA, CA, and SEOUL, South Korea – Nov. 11, 2025 – Wind River, an Aptiv company and global leader in delivering software for the intelligent edge, today announced that Hyundai Rotem, a leading provider of industrial rail and smart logistics solutions, will use Wind River® Studio Developer to modernize and automate its railway system software development environment.
Building on a 30-year relationship as a longtime VxWorks® customer, Hyundai Rotem will expand its use of Wind River solutions to advance its move toward cloud-native development –– driving greater flexibility, scalability, and efficiency as the company transitions to a software-defined rail system.
“We are thrilled to support Hyundai Rotem on its journey toward software-defined, autonomous transportation systems,” said Javed Khan, executive vice president and president of Software, Advanced Safety, and User Experience, Aptiv. “With Wind River, Hyundai Rotem can modernize its software development practices without compromising safety, security, or quality. This enables faster innovation, improved efficiency, and reduced costs while delivering secure, compliant, and reliable edge systems.”
“Leveraging Wind River technology, Hyundai Rotem is making a strategic shift toward software-defined functions, which will help us automate our development environment, accelerate innovation, and maximize ROI across current and future projects. Together with Wind River and their mission-critical expertise across industries, we are creating for the future of intelligent rail,” said Won-Sang Lee, vice president and chief technical officer, RS R&D Hub, Hyundai Rotem.
Studio Developer, a modern DevOps platform, will empower Hyundai Rotem with agile software development advancements such as CI/CD and cloud-native deployment to solve modern software development challenges that impede automation. Hyundai Rotem will also use Wind River Cloud Platform as the cloud infrastructure to host Studio Developer and will continue to use VxWorks for its safety-certified signaling and train control management system.
Studio Developer is designed to accelerate the development, deployment, and operation of mission-critical systems at the intelligent edge. It enables agile practices such as CI/CD and cloud-native deployment to overcome barriers to automation. By increasing automation and collaboration, Studio Developer improves developer efficiency, enables shift-left testing, boosts agility, and extends system lifetime value.
Cloud Platform provides a robust, on-premises private cloud solution to deploy and manage complex cloud architectures in the most demanding environments. VxWorks remains the industry’s most trusted real-time operating system (RTOS), ensuring the highest levels of safety, security, and reliability for mission-critical rail systems.
About Wind River
Wind River is a global leader in delivering software for the intelligent edge. For more than four decades, the company has been an innovator and pioneer, powering billions of devices and systems that require the highest levels of security, safety, and reliability. Wind River software and expertise are accelerating digital transformation across industries including automotive, aerospace, defense, industrial, medical, and telecommunications. The company offers a comprehensive portfolio supported by world-class global professional services and support and a broad partner ecosystem. To learn more, visit Wind River at www.windriver.com.
About Hyundai Rotem
Hyundai Rotem is a globally integrated enterprise that is helping to secure future sustainability in the areas of rail solutions, defense solutions, and eco-plants. The company is also pursuing a smart logistics business, supplying mobility products and automation facilities to increase logistical efficiency, including automated guided vehicles (AGVs), autonomous mobile robots (AMRs), and automated warehouse solutions. Hyundai Rotem further contributes to South Korean national security by developing ground weapon systems and smart unmanned weapon systems. For more information, visit Hyundai Rotem.
# # #
Continue Reading
-
Winners in the 22nd Annual Stevie® Awards for Women in Business Announced
Women-Owned Businesses and Professionals Were Honored at an Awards Ceremony in New York City
FAIRFAX, Va., Nov. 11, 2025 /PRNewswire/ — The Stevie® Awards for Women in Business, the world’s top honors for women entrepreneurs, executives, employees, and the organizations they run, have announced the 2025 winners.
The Stevie Awards for Women in Business is an international competition produced by the creators of the prestigious International Business Awards® and American Business Awards®. The Stevie is widely regarded as the world’s premier business award.
Stevie Awards for Women in Business winners were announced at a ceremony on November 10 in New York City.
Finalists in the 2025 competition were announced in September. The Gold, Silver, and Bronze Stevie Award placements among the Finalists were revealed at a gala event at New York’s Marriott Marquis Hotel on Monday, November 10. More than 550 nominated women professionals and their guests attended the presentations, which were broadcast live via Vimeo.
The 2025 competition attracted more than 1,500 nominations submitted by organizations and individuals in 48 nations. Winners were honored for achievements in more than 100 categories, including Executive of the Year, Entrepreneur of the Year, Most Innovative Company of the Year, Startup of the Year, and Women-Run Workplace of the Year. Over 200 business professionals from seven specialized judging committees determined the Gold, Silver, and Bronze Stevie Award winners.
Grand Stevie Award trophies were presented to five organizations that submitted the best body of entries to the competition, in their own names or in the names of one or more clients. These awards cannot be applied for directly. Grand winners were determined by the total number of Gold, Silver, and Bronze Stevie Awards won in the competition, with a Gold Stevie win counting for 3 points, a Silver Stevie for 2 points, and a Bronze Stevie counting for 1.5.
The 2025 Grand Stevie Award winners, listed in descending order by points, are as follows:
- Award Writing Services with 92 points for nine Gold, 25 Silver, and 10 Bronze Stevie Award wins on behalf of themselves and their clients
- Purpol Marketing Ltd., Chippenham, United Kingdom with 61 points with seven Gold, 14 Silver, and eight Bronze Stevie Award wins on behalf of themselves and their clients
- IBM, worldwide, with 29 points, for four Gold, four Silver, and six Bronze Stevie Award wins
- RISER, Armadale, Australia with 28.5 points for six Gold, three Silver, and three Bronze Stevie Awards on behalf of themselves and clients
- FASSLING.ai with 25 points for four Gold, five Silver, and two Bronze Stevie Award wins
The 2025 Gold, Silver, and Bronze Stevie Award winners reflect a diverse group of large and small organizations from around the world. Notable Gold Stevie Award winners in this year’s competition include:
- Donna Dror, CEO, Usercentrics, Munich, Germany, for Best Female CEO of the Year – Business Service
- Courtney Spaeth, CEO, growth[period], Tysons, VA USA for Best Female Entrepreneur in Business Services – 11 to 2,500 Employees
- MeiLee Langley, Vice President of Global Indirect Marketing, Nextiva, Inc., Phoenix, AZ USA for Female Executive of the Year ñ Business Products – 11 to 2,500 Employees
- Jelena Bajic, VP, TELUS Digital, Toronto, Canada, for Female Executive of the Year – Consumer Services – More Than 2,500 Employees
- Kristen Dalton, President, Tripadvisor, Needham, MA USA for Female Thought Leader of the Year – Consumer Services
- Prof. Olivia Mirza, Western Sydney University, Sydney, Australia, for Most Innovative Woman of the Year – Industry
- Peta Warby, Founder, SANAME, Gold Coast, Australia, for Woman of the Year – Industry
- Security Done Easy, Cary, NC USA for Best Female Business Blogger of the Year
- Öksüt Madencilik, Ankara, Türkiye, for Achievement in Women-related Corporate Social Responsibility
- Theory Crew, Armadale, Australia, for Achievement in Women-related Corporate Social Responsibility
- SuperFresh, Istanbul, Türkiye, for Achievement in Corporate Responsibility
- Mastercard, Nairobi, Kenya, for Achievement in Diversity, Equity & Inclusion
- PlayWise Partners, Los Angeles, CA USA for Achievement in Events & Observances Communications or PR
- Sempra, San Diego, CA USA for Achievement in Ethical Leadership
- Megaworld Lifestyle Malls, Taguig City, Philippines, for Achievement in Influencer Management
Organizations that won more than two or more Gold Stevie Awards, other than the Grand winners mentioned above, include Buy From A Black Woman, Atlanta GA USA, Chang Robotics, Jacksonville Beach, FL USA, Cherishers 818 CIC, Staffordshire, UK, Elivate, Tahoe City, CA USA, Fernwood Fitness, Melbourne, Australia, Global Touch, El Cerrito, CA USA, Health Focus Manufacturers Sydney, Australia, How Many Elephants, Alresford, UK, HR EXAM PREP with Angela, Canton, MS USA, Lisa Blair OAM, Sydney, Australia, Mastercard, Nairobi, Kenya, Megaworld Lifestyle Malls, Taguig City, Philippines, My Mountain Mover, Orange, CA USA, Pacvue, San Francisco, CA USA, Premier Inc., Washington DC, Rockwood Custom Homes, Calgary, Canada, SANAME, Gold Coast, Australia, Songue PR, San Francisco, CA, Spear & Arrow, Dubbo, Australia, The Divorce Course Podcast, Kenmore East, Australia, The Equine Practice Company, Clayfield, Australia, The Flora May Foundation, San Clemente, CA USA, The Ginsburg Firm, Brisbane, QLD Australia, Toptana Technologies, Taholah, WA USA, and Western Sydney University, Sydney, Australia.
Visit http://www.StevieAwards.com/Women for a complete list of Stevie winners by category.
About the Stevie Awards
Stevie Awards are conferred in nine programs: the Asia-Pacific Stevie Awards, the German Stevie Awards, The American Business Awards®, The International Business Awards®, the Middle East Stevie Awards, the Stevie Awards for Women in Business, the Stevie Awards for Great Employers, the Stevie Awards for Technology Excellence, and the Stevie Awards for Sales & Customer Service. Stevie Awards competitions receive more than 12,000 nominations each year from organizations in more than 70 nations and territories. Honoring organizations of all types and sizes and the people behind them, the Stevies recognize outstanding performances in the workplace worldwide. Learn more about the Stevie Awards at http://www.StevieAwards.com.
Contact:
Nina Moore
[email protected]
+1 (703) 547-8389SOURCE The Stevie Awards
Continue Reading
-
Private sector lost jobs in late October, new weekly ADP data shows
The private-sector job market contracted slightly in late October, according to a new report from payroll processing firm ADP.
Private sector employers shed an average of 11,250 jobs a week in the four weeks ending Oct. 25, “suggesting that the labor market struggled to produce jobs consistently during the second half of the month,” ADP said.
How the Federal Reserve perceives the labor market will be critical in their decision whether or not the central bankers to cut interest rates again at their meeting on Dec. 10.
This is breaking news. Check back for updates here.
BX:TMUBMUSD10Y
-Greg Robb
This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.
(END) Dow Jones Newswires
11-11-25 0838ET
Copyright (c) 2025 Dow Jones & Company, Inc.
The articles, information, and content displayed on this webpage may
include materials prepared and provided by third parties. Such
third-party content is offered for informational purposes only and
is not endorsed, reviewed, or verified by Morningstar.Morningstar makes no representations or warranties regarding the
accuracy, completeness, timeliness, or reliability of any third-party
content displayed on this site. The views and opinions expressed in
third-party content are those of the respective authors and do not
necessarily reflect the views of Morningstar, its affiliates, or employees.Morningstar is not responsible for any errors, omissions, or delays
in this content, nor for any actions taken in reliance thereon.
Users are advised to exercise their own judgment and seek independent
financial advice before making any decisions based on such content.
The third-party providers of this content are not affiliated with
Morningstar, and their inclusion on this site does not imply any
form of partnership, agency, or endorsement.Continue Reading
-
BIS, South African Reserve Bank announce winners of G20 TechSprint
- Fifteen shortlisted teams from around the world competed to develop innovative technological solutions to address trust and integrity in finance.
- Solutions aim to establish trust among financial institutions through digital identity solutions, improve the ability of small and medium-sized enterprises to finance through credit data portability, and drive wider adoption of fast payment systems globally by mitigating fraud and cyber risks.
- The winning teams are Team Ownapay SA (Proprietary) Ltd, Team Silence Laboratories Pte Ltd and Team FNA and Proto.
The Bank for International Settlements (BIS) and the South African Reserve Bank (SARB), under the South African G20 Presidency, today announced the winners of the G20 TechSprint 2025 challenge on trust and integrity in finance.
The G20 TechSprint is a joint initiative between the G20 Presidency and the BIS Innovation Hub to seek out best-in-class technological innovations aimed at solving challenges facing the global central banking and regulatory community.
This year’s TechSprint, the sixth edition of the G20 global hackathon open to developers from around the world, was launched in May.
Fifteen shortlisted teams presented their solutions to an independent panel of judges convened by the SARB in South Africa. Following are the winners for each of the three problem statements:
- Ownapay SA (Proprietary) Ltd, from South Africa, won the category for problem statement 1, which invited submissions on developing digital identity solutions: establishing trust among financial institutions through innovative, verifiable and privacy-preserving digital identity technologies.
- Silence Laboratories Pte Ltd, from Singapore, won the category for problem statement 2, which focused on credit data portability: improving the ability of small and medium-sized enterprises to finance through secure, consumer-consented data exchange solutions that facilitate seamless cross-border sharing of credit information.
- FNA and Proto, from the United Kingdom, won the category for problem statement 3, which called for solutions to mitigate fraud and cyber risks: driving wider adoption of fast payment systems globally – and promoting financial inclusion and economic growth – through technology designed to reduce fraud and cyber risks.
The 2025 edition of TechSprint has addressed trust and integrity, while advancing scalability and promoting financial inclusion.
Thank you to all who contributed for your curiosity, discipline and commitment to a more open and trusted financial future.
Pablo Hernández de Cos, General Manager of the BIS
As policymakers, our unwavering commitment to fostering innovation is crucial. The G20 TechSprint has once again shown that some of the most scalable and forward-thinking solutions to global financial challenges can emerge from fintech start-ups in small towns as well as seasoned developers in global hubs.
Hosting the TechSprint on African soil for the first time revealed the depth of talent and ingenuity across our continent and beyond. The solutions put forward underscore the urgent need to build open, trusted and inclusive financial systems that transcend borders and serve everyone.
Lesetja Kganyago, Governor, SARB
Shortlisted teams
Problem statement 1
- Currency Network Ltd
- Meeco
- Ownapay SA (Proprietary) Ltd
- Settlefirst Assetsworks Private Ltd
- walt.id
Problem statement 2
- Akiba Digital (Pty) Ltd
- A team of eight individuals led by Amit Bapat1
- eSusFarm Africa
- Silence Laboratories Pte Ltd
- Smile Technology Pte Ltd
Problem statement 3
- Banfico VOP
- ContexQ
- FNA and Proto
- Kasikorn Soft Company Ltd
- Mastercard
List of judges
- Dr Joseph Atick, Executive Chairman, ID4Africa
- Mr Raymond Chan, Executive Director (Enforcement and AML), Hong Kong Monetary Authority
- Ms Mary Beth Christie, Independent non-Executive Director, Open Banking UK
- Ms Violaine Clerc, Executive Secretary, Financial Action Task Force
- Mr Jeremy Gray, Technical Director, Cenfri
- Ms Gail Hodges, Executive Director, OpenID Foundation
- Mr Guilherme Themes Miguel Jose, Head of Division at the Financial System Regulation Department, Central Bank of Brazil
- Mr Stephen Linnell, Chief Executive Officer, PayInc
- Mr Mark Munne, Head of Technology, Nexus Global Payments
- Mr Kwame Oppong, Former Head FinTech and Innovation, Bank of Ghana
- Mr P Vasudevan, Executive Director, Reserve Bank of India
Continue Reading
-
Uli-epic: profiling RNA modifications from ultra-low input samples | Genome Biology
McCown PJ, Ruszkowska A, Kunkler CN, Breger K, Hulewicz JP, Wang MC, et al. Naturally occurring modified ribonucleosides. WIREs RNA. 2020;11:e1595.
Google Scholar
Liu N, Dai Q, Zheng G, He C, Parisien M, Pan T. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature. 2015;518:560–4.
Google Scholar
He PC, Wei J, Dou X, Harada BT, Zhang Z, Ge R, et al. Exon architecture controls mRNA m(6)A suppression and gene expression. Science. 2023;379:677–82.
Google Scholar
Liu J, Dou X, Chen C, Chen C, Liu C, Xu MM, et al. N (6)-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription. Science. 2020;367:580–6.
Google Scholar
Xu W, Li J, He C, Wen J, Ma H, Rong B, et al. METTL3 regulates heterochromatin in mouse embryonic stem cells. Nature. 2021;591:317–21.
Google Scholar
Wei J, Yu X, Yang L, Liu X, Gao B, Huang B, et al. FTO mediates LINE1 m(6)a demethylation and chromatin regulation in mESCs and mouse development. Science. 2022;376(6596):968–73.
Google Scholar
Frye M, Harada BT, Behm M, He C. RNA modifications modulate gene expression during development. Science. 2018;361:1346–9.
Google Scholar
Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, et al. YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs. Elife. 2017. https://doi.org/10.7554/eLife.31311.
Google Scholar
Liu C, Dou X, Zhao Y, Zhang L, Zhang L, Dai Q, et al. IGF2BP3 promotes mRNA degradation through internal m(7)g modification. Nat Commun. 2024;15:7421.
Google Scholar
Wang X, Lu Z, Gomez A, Hon GC, Yue Y, Han D, et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature. 2014;505:117–20.
Google Scholar
Dominissini D, Nachtergaele S, Moshitch-Moshkovitz S, Peer E, Kol N, Ben-Haim MS, et al. The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA. Nature. 2016;530:441–6.
Google Scholar
Wang X, Zhao BS, Roundtree IA, Lu Z, Han D, Ma H, et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell. 2015;161:1388–99.
Google Scholar
Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature. 2012;485:201–6.
Google Scholar
Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell. 2012;149:1635–46.
Google Scholar
Li Y, Wang Y, Vera-Rodriguez M, Lindeman LC, Skuggen LE, Rasmussen EMK, et al. Single-cell m(6)A mapping in vivo using picoMeRIP-seq. Nat Biotechnol. 2024;42:591–6.
Google Scholar
Yao H, Gao CC, Zhang D, Xu J, Song G, Fan X, et al. Scm(6)A-seq reveals single-cell landscapes of the dynamic m(6)A during oocyte maturation and early embryonic development. Nat Commun. 2023;14:315.
Google Scholar
Hamashima K, Wong KW, Sam TW, Teo JHJ, Taneja R, Le MTN, et al. Single-nucleus multiomic mapping of m(6)A methylomes and transcriptomes in native populations of cells with sn-m6A-CT. Mol Cell. 2023. https://doi.org/10.1016/j.molcel.2023.08.010.
Google Scholar
McIntyre ABR, Gokhale NS, Cerchietti L, Jaffrey SR, Horner SM, Mason CE. Limits in the detection of m6A changes using MeRIP/m6A-seq. Sci Rep. 2020;10:6590.
Google Scholar
Hu L, Liu S, Peng Y, Ge R, Su R, Senevirathne C, et al. M(6)a RNA modifications are measured at single-base resolution across the mammalian transcriptome. Nat Biotechnol. 2022;40:1210–9.
Google Scholar
Liu C, Sun H, Yi Y, Shen W, Li K, Xiao Y, et al. Absolute quantification of single-base m(6)A methylation in the mammalian transcriptome using GLORI. Nat Biotechnol. 2023;41:355–66.
Google Scholar
Shen W, Sun H, Liu C, Yi Y, Hou Y, Xiao Y, et al. Glori for absolute quantification of transcriptome-wide m(6)a at single-base resolution. Nat Protoc. 2024;19:1252–87.
Google Scholar
Li X, Xiong X, Zhang M, Wang K, Chen Y, Zhou J, et al. Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts. Mol Cell. 2017;68(993–1005):e1009.
Zhou H, Rauch S, Dai Q, Cui X, Zhang Z, Nachtergaele S, et al. Evolution of a reverse transcriptase to map N(1)-methyladenosine in human messenger RNA. Nat Methods. 2019;16:1281–8.
Google Scholar
Pajdzik K, Lyu R, Dou X, Ye C, Zhang LS, Dai Q, et al. Chemical manipulation of m(1)A mediates its detection in human tRNA. RNA. 2024;30:548–59.
Google Scholar
Ge R, Ye C, Peng Y, Dai Q, Zhao Y, Liu S, et al. M(6)A-SAC-seq for quantitative whole transcriptome m(6)a profiling. Nat Protoc. 2023;18:626–57.
Google Scholar
Xu H, Kong L, Cheng J, Al Moussawi K, Chen X, Iqbal A, et al. Absolute quantitative and base-resolution sequencing reveals comprehensive landscape of pseudouridine across the human transcriptome. Nat Methods. 2024. https://doi.org/10.1038/s41592-024-02439-8.
Google Scholar
Zhang M, Jiang Z, Ma Y, Liu W, Zhuang Y, Lu B, et al. Quantitative profiling of pseudouridylation landscape in the human transcriptome. Nat Chem Biol. 2023;19:1185–95.
Google Scholar
Dai Q, Ye C, Irkliyenko I, Wang Y, Sun HL, Gao Y, et al. Ultrafast bisulfite sequencing detection of 5-methylcytosine in DNA and RNA. Nat Biotechnol. 2024. https://doi.org/10.1038/s41587-023-02034-w.
Google Scholar
Lu L, Zhang X, Zhou Y, Shi Z, Xie X, Zhang X, et al. Base-resolution m(5)C profiling across the mammalian transcriptome by bisulfite-free enzyme-assisted chemical labeling approach. Mol Cell. 2024;84(2984–3000):e2988.
Marchand V, Ayadi L, Ernst FGM, Hertler J, Bourguignon-Igel V, Galvanin A, et al. Alkaniline-seq: profiling of m(7) G and m(3) C RNA modifications at single nucleotide resolution. Angew Chem Int Ed Engl. 2018;57:16785–90.
Google Scholar
Zhang LS, Liu C, Ma H, Dai Q, Sun HL, Luo G, et al. Transcriptome-wide Mapping of Internal N(7)-Methylguanosine Methylome in Mammalian mRNA. Mol Cell. 2019;74(1304–1316):e1308.
Sas-Chen A, Thomas JM, Matzov D, Taoka M, Nance KD, Nir R, et al. Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature. 2020;583:638–43.
Google Scholar
Beiki H, Sturgill D, Arango D, Relier S, Schiffers S, Oberdoerffer S. Detection of ac4C in human mRNA is preserved upon data reassessment. Mol Cell. 2024;84(1611–1625):e1613.
Zhang LS, Ju CW, Jiang B, He C. Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA. Methods Enzymol. 2023;692:39–54.
Google Scholar
Gynecologists ACO: ACOG Practice Bulletin No. 227: Fetal Growth Restriction. Obstetrics Gynecol. 2021;137:754.
Gilchrist C, Cumberland A, Walker D, Tolcos M. Intrauterine growth restriction and development of the hippocampus: implications for learning and memory in children and adolescents. Lancet Child Adolesc Health. 2018;2:755–64.
Google Scholar
Hoek HW, Susser E, Buck KA, Lumey LH, Lin SP, Gorman JM. Schizoid personality disorder after prenatal exposure to famine. Am J Psychiatry. 1996;153:1637–9.
Google Scholar
Chen YY, Zhou LA. The long-term health and economic consequences of the 1959–1961 famine in China. J Health Econ. 2007;26:659–81.
Google Scholar
Tsikouras P, Antsaklis P, Nikolettos K, Kotanidou S, Kritsotaki N, Bothou A, et al. Diagnosis, prevention, and management of fetal growth restriction (FGR). J Pers Med. 2024. https://doi.org/10.3390/jpm14070698.
Google Scholar
Chen W, Liu N, Shen S, Zhu W, Qiao J, Chang S, et al. Fetal growth restriction impairs hippocampal neurogenesis and cognition via Tet1 in offspring. Cell Rep. 2021;37:109912.
Google Scholar
Veenendaal MVE, Painter RC, de Rooij SR, Bossuyt PMM, van der Post JAM, Gluckman PD, et al. Transgenerational effects of prenatal exposure to the 1944–45 Dutch famine. BJOG. 2013;120:548–54.
Google Scholar
Yao WY, Yu YF, Li LH, Xu WH. Exposure to Chinese famine in early life and height across 2 generations: a longitudinal study based on the China Health and Nutrition Survey. Am J Clin Nutr. 2024;119:433–43.
Google Scholar
Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, Seisenberger S, Hore TA, Reik W, Erkek S, et al: In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism. Science. 2014;345:785.
Zhang ZM, Luo XF, Lv Y, Yan LL, Xu SS, Wang Y, et al. Intrauterine growth restriction programs intergenerational transmission of pulmonary arterial hypertension and endothelial dysfunction via sperm epigenetic modifications. Hypertension. 2019;74:1160–71.
Google Scholar
Borchardt EK, Martinez NM, Gilbert WV. Regulation and function of RNA pseudouridylation in human cells. Annu Rev Genet. 2020;54:309–36.
Google Scholar
Zhang LS, Ye C, Ju CW, Gao B, Feng X, Sun HL, et al. BID-seq for transcriptome-wide quantitative sequencing of mRNA pseudouridine at base resolution. Nat Protoc. 2024;19:517–38.
Google Scholar
Santiago J, Silva JV, Howl J, Santos MAS, Fardilha M. All you need to know about sperm RNAs. Hum Reprod Update. 2021;28:67–91.
Google Scholar
Chen Q, Yan W, Duan E. Epigenetic inheritance of acquired traits through sperm RNAs and sperm RNA modifications. Nat Rev Genet. 2016;17:733–43.
Google Scholar
Herridge RP, Dolata J, Migliori V, Alves CD, Borges F, Schorn AJ, van Ex F, Lin A, Bajczyk M, Parent JS, et al. Pseudouridine guides germline small RNA transport and epigenetic inheritance. Nat Struct Mol Biol. 2025 Feb;32(2):277-86.
Suzuki T. The expanding world of tRNA modifications and their disease relevance. Nat Rev Mol Cell Biol. 2021;22:375–92.
Google Scholar
Wang C, Lu CF, Peng J, Hu CD, Wang Y. Roles of neural stem cells in the repair of peripheral nerve injury. Neural Regen Res. 2017;12:2106–12.
Google Scholar
Wen C, Cao L, Wang S, Xu W, Yu Y, Zhao S, et al. MCM8 interacts with DDX5 to promote R-loop resolution. EMBO J. 2024;43:3044–71.
Google Scholar
Zhai Y, Cheng E, Wu H, Li N, Yung PY, Gao N, et al. Open-ringed structure of the Cdt1-Mcm2-7 complex as a precursor of the MCM double hexamer. Nat Struct Mol Biol. 2017;24:300–8.
Google Scholar
Wang P, Ye C, Zhao M, Jiang B, He C. Small-molecule-catalysed deamination enables transcriptome-wide profiling of N(6)-methyladenosine in RNA. Nat Chem. 2025. https://doi.org/10.1038/s41557-025-01801-3.
Google Scholar
Sun H, Lu B, Zhang Z, Xiao Y, Zhou Z, Xi L, et al. Mild and ultrafast GLORI enables absolute quantification of m(6)A methylome from low-input samples. Nat Methods. 2025. https://doi.org/10.1038/s41592-025-02680-9.
Google Scholar
Li Y, Xue J, Ma Y, Ye K, Zhao X, Ge F, et al. The complex roles of m 6 A modifications in neural stem cell proliferation, differentiation, and self-renewal and implications for memory and neurodegenerative diseases. Neural Regen Res. 2025;20:1582–98.
Google Scholar
Lv J, Xing L, Zhong X, Li K, Liu M, Du K. Role of N6-methyladenosine modification in central nervous system diseases and related therapeutic agents. Biomed Pharmacother. 2023;162:114583.
Google Scholar
Wan X, Ge Y, Xu S, Feng Y, Zhu Y, Yin L, et al. M(6)a modification and its role in neural development and neurological diseases. Epigenomics. 2023;15:819–33.
Google Scholar
Gui Y, Yuan S. Epigenetic regulations in mammalian spermatogenesis: RNA-m(6)a modification and beyond. Cell Mol Life Sci. 2021;78:4893–905.
Google Scholar
Lin Z, Hsu PJ, Xing X, Fang J, Lu Z, Zou Q, et al. Mettl3-/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis. Cell Res. 2017;27:1216–30.
Google Scholar
Huang T, Liu ZD, Zheng Y, Feng TY, Gao Q, Zeng WX. YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m6A/mRNA pathway. Cell Death Dis. 2020. https://doi.org/10.1038/s41419-020-2235-4.
Google Scholar
Wu YF, Li JC, Li CMJ, Lu S, Wei XY, Li Y, et al. Fat mass and obesity-associated factor (FTO)-mediated N6-methyladenosine regulates spermatogenesis in an age-dependent manner. J Biol Chem. 2023. https://doi.org/10.1016/j.jbc.2023.104783.
Google Scholar
Myers BL, Brayer KJ, Paez-Beltran LE, Villicana E, Keith MS, Suzuki H, et al. Transcription factors ASCL1 and OLIG2 drive glioblastoma initiation and co-regulate tumor cell types and migration. Nat Commun. 2024;15:10363.
Google Scholar
Hoeck JD, Jandke A, Blake SM, Nye E, Spencer-Dene B, Brandner S, et al. Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun. Nat Neurosci. 2010;13:1365–72.
Google Scholar
Torii MA, Matsuzaki F, Osumi N, Kaibuchi K, Nakamura S, Casarosa S, et al. Transcription factors Mash-1 and Prox-1 delineate early steps in differentiation of neural stem cells in the developing central nervous system. Development. 1999;126:443–56.
Google Scholar
Karalay Ö, Doberauer K, Vadodaria KC, Knobloch M, Berti L, Miquelajauregui A, et al. Prospero-related homeobox 1 gene (Prox1) is regulated by canonical Wnt signaling and has a stage-specific role in adult hippocampal neurogenesis. Proc Natl Acad Sci U S A. 2011;108:5807–12.
Google Scholar
Salmen F, De Jonghe J, Kaminski TS, Alemany A, Parada GE, Verity-Legg J, et al. High-throughput total RNA sequencing in single cells using VASA-seq. Nat Biotechnol. 2022;40:1780–93.
Google Scholar
Turchinovich A, Surowy H, Serva A, Zapatka M, Lichter P, Burwinkel B. Capture and amplification by tailing and switching (CATS). An ultrasensitive ligation-independent method for generation of DNA libraries for deep sequencing from picogram amounts of DNA and RNA. RNA Biol. 2014;11:817–28.
Google Scholar
Chen C, Xing D, Tan L, Li H, Zhou G, Huang L, et al. Single-cell whole-genome analyses by linear amplification via transposon insertion (LIANTI). Science. 2017;356:189–94.
Google Scholar
Cui XL, Nie J, Zhu H, Kowitwanich K, Beadell AV, West-Szymanski DC, et al. LABS: linear amplification-based bisulfite sequencing for ultrasensitive cancer detection from cell-free DNA. Genome Biol. 2024;25:157.
Google Scholar
Xie R, Yang X, He W, Luo Z, Li W, Xu C, et al. LAMP-MS for locus-specific visual quantification of DNA 5 mC and RNA m(6)A using ultra-low input. Angew Chem Int Ed Engl. 2025;64:e202413872.
Google Scholar
Lyu J, Chen C. LAST-seq: single-cell RNA sequencing by direct amplification of single-stranded RNA without prior reverse transcription and second-strand synthesis. Genome Biol. 2023;24:184.
Google Scholar
Verboom K, Everaert C, Bolduc N, Livak KJ, Yigit N, Rombaut D, et al. SMARTer single cell total RNA sequencing. Nucleic Acids Res. 2019;47:e93.
Google Scholar
Eyler DE, Franco MK, Batool Z, Wu MZ, Dubuke ML, Dobosz-Bartoszek M, et al. Pseudouridinylation of mRNA coding sequences alters translation. Proc Natl Acad Sci U S A. 2019;116:23068–74.
Google Scholar
Deogharia M, Mukhopadhyay S, Joardar A, Gupta R. The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. RNA. 2019;25:336–51.
Google Scholar
Song J, Zhuang Y, Zhu C, Meng H, Lu B, Xie B, et al. Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. Nat Chem Biol. 2020;16:160–9.
Google Scholar
Mukhopadhyay S, Deogharia M, Gupta R. Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. RNA. 2021;27:66–79.
Google Scholar
Behm-Ansmant I, Massenet S, Immel F, Patton JR, Motorin Y, Branlant C. A previously unidentified activity of yeast and mouse RNA:pseudouridine synthases 1 (Pus1p) on tRNAs. RNA. 2006;12:1583–93.
Google Scholar
Feinberg JS, Joseph S. Identification of molecular interactions between P-site tRNA and the ribosome essential for translocation. Proc Natl Acad Sci U S A. 2001;98:11120–5.
Google Scholar
Helm M, Brule H, Degoul F, Cepanec C, Leroux JP, Giege R, et al. The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA. Nucleic Acids Res. 1998;26:1636–43.
Google Scholar
Zhang J, Xiong YW, Tan LL, Zheng XM, Zhang YF, Ling Q, et al. Sperm Rhoa m6A modification mediates intergenerational transmission of paternally acquired hippocampal neuronal senescence and cognitive deficits after combined exposure to environmental cadmium and high-fat diet in mice. J Hazard Mater. 2023;458:131891.
Google Scholar
Zhou Y, Lian C, Lu Y, Wang T, Zhao C, Zhang C, Gong M, Chen J, Ju R: Maternal androgen exposure induces intergenerational effects via paternal inheritance. J Endocrinol. 2024;262(2):e230368.
Mao Y, Meng Y, Zou K, Qin N, Wang Y, Yan J, et al. Advanced paternal age exacerbates neuroinflammation in offspring via m6A modification-mediated intergenerational inheritance. J Neuroinflammation. 2024;21:249.
Google Scholar
He W, Yin X, Xu C, Liu X, Huang Y, Yang C, et al. Ascorbic acid reprograms epigenome and epitranscriptome by reducing Fe(III) in the catalytic cycle of dioxygenases. ACS Chem Biol. 2024;19:129–40.
Google Scholar
Hu L, Xu C, He W. Uli-Epic: A cutting-edge library construction strategy for profiling ultra-limited RNA modifications [Uli-Epic BID-seq] Gene Expression Omnibus. 2024. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?&acc=GSE277358.
Uli-Epic: A cutting-edge library construction strategy for profiling ultra-limited RNA modifications [Uli-Epic GLORI] Gene Expression Omnibus. 2024. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE277359.
Hu L, Xu C, He W. Ascorbic acid reprogrames epigenome and epitranscriptome by recycling Fe (III) into Fe (II) in the catalytic cycle of dioxygenases. Gene Expression Omnibus. 2024. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE242760.
Continue Reading
-
At 3 Years, Eque-Cel Displays Deep and Durable Responses in Relapsed Multiple Myeloma
The therapeutic landscape of relapsed or refractory multiple myeloma has evolved rapidly with the advent of BCMA-directed cellular therapies, offering the possibility of deep and durable responses in a setting historically characterized by diminishing treatment returns with each subsequent line of therapy. However, questions have remained regarding long-term durability, late relapse, and safety with extended follow-up. Updated 3-year results from the phase 1b/2 FUMANBA-1 trial (NCT05066646; CTR20192510) presented by investigators from the China Academy of Chinese Medical Sciences at the
22nd Annual International Myeloma Society (IMS) Meeting and Exposition begin to address these gaps.1In the study, equecabtagene autoleucel (eque-cel; Fucaso), a fully human anti-BCMA CAR T-cell therapy, continued to demonstrate sustained clinical activity at a median follow-up of 36 months. Among 107 efficacy-evaluable patients, the objective response rate (ORR) reached 96.3%, including an 83.2% complete response (CR) or better rate. In CAR T-cell therapy–naive patients (n = 95), outcomes were even more pronounced, with ORR and CR rates of 98.9% and 88.4%, respectively. The median progression-free survival (PFS) was 30.46 months (95% CI, 24.11-42.15) in the overall population, extending to 39.82 months (95% CI, 30.26-not reached) among patients achieving at least a CR and 35.91 months (95% CI, 25.95-47.67) among those without prior CAR T-cell therapy. The median overall survival (OS) had not yet been reached, with 66.3% of patients alive at 3 years.
“Eque-cel is an excellent product, and I hope it [will] benefit patients around the world,” lead study author Lugui Qiu, MD, shared in an interview with OncLive®, where he expanded on the clinical significance of these results, the durability of responses observed with eque-cel, and how these data inform the positioning of BCMA-directed CAR T-cell therapy in contemporary myeloma treatment sequencing.
Qiu is part of the National Clinical Research Center for Blood Diseases, the State Key Laboratory of Experimental Hematology, and the Blood Diseases Hospital & Institute of Hematology at the Chinese Academy of Medical Sciences & Peking Union Medical College.
OncLive: How was the phase 1b/2 FUMANBA-1 trial designed?
Qiu: The study was designed as a registrational trial that evaluated eque-cel, a fully human anti-BCMA CAR-T cell therapy originally from a biotech [company] in China. This study started in 2019, and the enrollment finished in 1 year, so it went well.
On June 30, 2023, eque-cel was
approved by China’s National Medical Products Administration for relapsed and refractory multiple myeloma patients who had received at least 3 lines of prior therapy, including at least 1 proteasome inhibitor and an immunomodulatory drug [IMiD].2What long-term findings were presented at IMS?
There were a total of 109 patients enrolled in this clinical trial, and 107 patients were efficacy evaluable. The total response rate was [96.3]%, and the CR [or better] rate was [83.2]%. We enrolled 12 patients who had received prior BCMA-directed CAR-T therapy. For those patients, the total response rate was 75%, with a median PFS of [approximately] 1 year. For patients without prior BCMA-directed CAR T-cell therapy, the total response was [98.9]%, and the CR rate was [88.4]%.
After a median follow-up of 3 years, in the whole group, the median PFS was [30.46] months. For the 95 patients without prior CAR-T therapy, the median PFS was [35.91] months, and the median OS was not yet reached. [In total], 66.3% of patients were still alive at the 3-year follow-up.
What was observed with regard to the safety profile?
The safety profile is [good]. During the trial, [93.6]% of patients [experienced CRS], but mostly grade 1 or grade 2. Only 1 patient experienced grade 3 CRS, and there were only 2 patients who [developed] ICANS. There were no toxicity-related deaths in this trial.
Several commercial BCMA-directed CAR-T therapies are [available globally]. In my impression, eque-cel has efficacy comparable with ciltacabtagene ciloleucel, and the safety profile is better than idecabtagene vicleucel. Eque-cel is a good product balancing [both] the efficacy and safety profiles.
What are the next steps for analyzing eque-cel in patients with relapsed/refractory multiple myeloma?
We have also launched a real-world study of eque-cel in relapsed and refractory multiple myeloma following market approval. [At IMS, we had] a poster reporting 150 cases from this real-world study. The results show that the efficacy and safety profile in the real-world setting were similar to [those in] our clinical trial.
This product has benefited many heavily pretreated patients, including those previously treated with proteasome inhibitors, IMiDs, anti-CD38 antibodies, and even some patients who had prior BCMA-directed CAR T-cell therapy. [These patients] can still benefit from eque-cel.
References
- Li C, Zou D, Zhou K, et al. Three-year follow-up of FUMANBA-1: a phase 1b/2 study of fully human anti-BCMA CAR-T equecabtagene autoleucel in patients with relapsed/refractory multiple myeloma. Presented at the 22nd Annual International Myeloma Society Meeting and Exposition; September 17-20, 2025; Toronto, Canada. Abstract OA-08.
- Innovent and IASO Bio announce the NMPA approval of Fucaso, the first fully-human BCMA CAR-T therapy for the treatment of relapsed or refractory multiple myeloma. News release. Innovent Biologics, Inc. July 3, 2023. Accessed November 11, 2025. https://www.iasobio.com/info.php?id=224
Continue Reading
-
S&P Global to Present at J.P. Morgan 2025 Ultimate Services Investor Conference on November 18, 2025
S&P Global to Present at J.P. Morgan 2025 Ultimate Services Investor Conference on November 18, 2025
Session will be Webcast
NEW YORK, Nov. 11, 2025 /PRNewswire/ — Martina Cheung, President and Chief Executive Officer of S&P Global (NYSE: SPGI), will participate in J.P. Morgan’s 2025 Ultimate Services Investor Conference on November 18, 2025 in New York, New York. Ms. Cheung is scheduled to speak from 9:00 a.m. to 9:30 a.m. (Eastern Standard Time). The “fireside chat” will be webcast and may include forward-looking information.
Webcast Instructions: Live and Replay
The webcast (audio-only) will be available live and in replay through the Company’s Investor Relations website http://investor.spglobal.com/Investor-Presentations (please copy and paste URL into web browser). The webcast replay will be available within 24 hours after the end of the presentation and will remain accessible for 30 days, ending on December 18, 2025. Any additional information presented during the session will be made available on the Company’s Investor Presentations web page.About S&P Global
S&P Global (NYSE: SPGI) provides essential intelligence. We enable governments, businesses and individuals with the right data, expertise and connected technology so that they can make decisions with conviction. From helping our customers assess new investments to guiding them through sustainability and energy transition across supply chains, we unlock new opportunities, solve challenges and accelerate progress for the world.We are widely sought after by many of the world’s leading organizations to provide credit ratings, benchmarks, analytics and workflow solutions in the global capital, commodity and automotive markets. With every one of our offerings, we help the world’s leading organizations plan for tomorrow, today. For more information, visit www.spglobal.com.
Investor Relations: http://investor.spglobal.com
Contacts:
Investor Relations
Mark Grant
Senior Vice President, Investor Relations and Treasurer
Tel: + 1 (347) 640-1521
mark.grant@spglobal.comMedia
Orla O’Brien
Global Head of Public Relations
Tel: +1 (857) 407-8559
orla.obrien@spglobal.comSOURCE S&P Global
Continue Reading