Category: 3. Business

  • Google proposes app store reforms in settlement with ‘Fortnite’ maker Epic Games

    Google proposes app store reforms in settlement with ‘Fortnite’ maker Epic Games

    WASHINGTON, (Reuters) Nov 4 – Alphabet’s (GOOGL.O), opens new tab Google said on Tuesday it has reached a comprehensive U.S. court settlement with “Fortnite” video game maker Epic Games, agreeing to Android and app store reforms aimed at lowering fees, boosting competition and expanding choices for developers and consumers.
    In a joint filing, opens new tab in the federal court in San Francisco, the companies asked U.S. District Judge James Donato to consider a proposal resolving Epic’s 2020 antitrust lawsuit, which accused Google of illegally monopolizing how users access apps and make in-app purchases on Android devices.

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    Google has denied any wrongdoing throughout the closely watched litigation.

    The proposal requires Donato’s approval. The judge oversaw a jury trial in 2023 that Epic won and last year he issued a sweeping injunction mandating Play app store reforms that Google said went too far. Google said the reforms potentially harmed its competitive position and compromised user safety.

    Under the new proposal, Google would allow users to more easily download and install third-party app stores that meet new security and safety standards.

    Developers will also be allowed to direct users to alternative payment methods both within apps and via external web links. Google said it would implement a capped service fee of either 9% or 20% on transactions in Play-distributed apps that use alternative payment options.

    Sameer Samat, Google’s president of Android Ecosystem, said, opens new tab on Tuesday the proposed changes maintained user safety while increasing flexibility for developers and consumers. Samat said Google looked forward to discussing the resolution with Donato, who is expected on Thursday to meet with lawyers involved with the case at a previously scheduled hearing.
    Epic Games CEO Tim Sweeney called, opens new tab Google’s proposal “awesome” and said it “genuinely doubles down on Android’s original vision as an open platform.”
    Google unsuccessfully challenged Donato’s injunction in a federal appeals court, which upheld it in a ruling in July. The U.S. Supreme Court last month declined Google’s request to temporarily freeze parts of the injunction.

    Tuesday’s court filing from Google and Epic asked Donato to modify his injunction, while keeping many parts of it intact.

    Google faces other lawsuits from government, consumer and commercial plaintiffs challenging its search and advertising business practices. It has denied violating state and federal laws in those cases.

    Reporting by Mike Scarcella; Editing by Muralikumar Anantharaman and Thomas Derpinghaus

    Our Standards: The Thomson Reuters Trust Principles., opens new tab

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  • Mitsubishi Power Receives Contract to Upgrade Existing Boiler Equipment at the O Mon 1 Thermal Power Plant in Vietnam– Playing a Central Role in the Oil-to-Natural Gas Fuel Conversion Project —

    Mitsubishi Power Receives Contract to Upgrade Existing Boiler Equipment at the O Mon 1 Thermal Power Plant in Vietnam– Playing a Central Role in the Oil-to-Natural Gas Fuel Conversion Project —

    O Mon 1 Thermal Power Plant (Photo: EVNGENCO2)

    Tokyo, November 5, 2025 – Mitsubishi Power, a power solutions brand of Mitsubishi Heavy Industries, Ltd. (MHI), has received a contract to support the oil-to-natural gas fuel conversion project at the O Mon 1 Thermal Power Plant in Can Tho in southern Vietnam.

    Mitsubishi Power will provide the main equipment, such as the gas burners for the boiler at the core of the system, leveraging its technological capabilities as the OEM (original equipment manufacturer) of the existing boiler to carry out the fuel conversion, and contribute to reductions in CO2 emissions. In addition, Mitsubishi Power will install a selective catalytic reduction (SCR) system to detoxify the NOx (nitrogen oxides) contained in exhaust gases, allowing the plant to meet stricter environmental regulations in the future.

    The O Mon 1 Thermal Power Plant comprises Units 1 (330 megawatts (MW)) and Unit 2 (330 MW), which started operation in 2009 and 2015, respectively. The total output is 660 MW, with the existing main equipment provided by Mitsubishi Power.

    The fuel conversion project is being conducted by Power Generation Corporation 2 (EVNGENCO2), a part of Vietnam Electricity Corporation (EVN) Group. The contractor for engineering, procurement, and construction (EPC) is a consortium of LILAMA Corporation, a construction company under Vietnam’s Ministry of Construction, and Power Generation Corporation 3 (EVNGENCO3), also part of EVN Group. Mitsubishi Power received the contract for the main equipment from this consortium. Mitsubishi Power Asia Pacific Pte. Ltd., a part of MHI Group based in Singapore, will carry out the EPC engineering support and dispatch personnel to provide technical assistance.

    Commenting on the contract award, Makoto Fujita, Senior General Manager, Steam Power Business Division, Energy Systems at MHI, said, “Since the start of operations for Unit 1 in 2009, the O Mon 1 Thermal Power Plant has played an important role in the development of the Mekong Delta region. As the OEM of the existing power plant, we are extremely proud to be able to contribute to the stable supply of energy and decarbonization in Vietnam through our participation in this fuel conversion project. We will devote our full effort to completing this project, and provide support for the long-term, stable operation of the plant.”

    In August this year, Mitsubishi Power received a contract to supply two advanced J-Series Air-Cooled (JAC) gas turbines as the core equipment for the O Mon 4 Thermal Power Plant, a gas turbine combined cycle (GTCC) facility with a designed capacity of 1,155 MW, which is adjacent to the O Mon 1 Thermal Power Plant. The project is scheduled for completion in 2028. Vietnam has formulated the Power Development Plan VIII (PDP8), which calls for diversifying the energy mix, reducing coal dependency, and expanding natural gas and renewable energy. Mitsubishi Power, in addition to providing GTCC technology for the O Mon 4 Thermal Power Plant, will further strengthen its support for Vietnam’s energy plan by providing boiler fuel conversion technology for the O Mon 1 Thermal Power Plant, contributing to Vietnam’s national target of achieving net zero emissions by 2050.

    Akihiro Ondo, CEO and Managing Director of Mitsubishi Power Asia Pacific Pte. Ltd., said, “Vietnam boasts the highest real GDP growth rate among the ASEAN-5 nations. We are committed to contributing to Vietnam’s economic development by leveraging cutting-edge technology and providing meticulous services.”

    Mitsubishi Power will further enhance its efforts for the widespread adoption of technologies with high performance and reliability, contributing to the stable supply of electric power essential for economic development around the world, and supporting the conservation of the global environment by promoting energy decarbonization.

    Group Photo at the Signing Ceremony

    Group Photo at the Signing Ceremony

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  • Singapore’s Jurong Island green energy plans ‘an opportunity’ for tech, infrastructure and energy firms

    Singapore’s Jurong Island green energy plans ‘an opportunity’ for tech, infrastructure and energy firms

    Jurong Island has traditionally relied on fossil fuels to generate the required power for the production of petroleum products, polymers and refineries, alongside other industries, that have made the island an industrial powerhouse for Singapore. Close to 300 hectares (ha) will be allocated for new energies, such as hydrogen-ready natural gas, ammonia and biogas.

    The government has also announced that Singapore will build a 700-megawatt (MW) data centre park on Jurong Island, which will be designed to meet efficiency standards, adopt advanced cooling systems and use green energy sources.

    William Stroll, an expert in energy projects at Pinsent Masons, said: “Following the lifting of the moratorium on new data centres in 2022, we’ve seen cautious growth of around 80MW of new capacity approved under strict sustainability criteria.” 

    “The announcement of 20ha on Jurong Island, roughly the size of 25 football fields, for a low-carbon data centre park marks a significant shift. Co-locating data centres with power-hungry, performance-driven workloads matching them to the availability of green energy sources, including four hydrogen-ready power plants, signals a bold step toward sustainable digital infrastructure, and meeting the fast-growing demands,” he said.

    “With recent assessments highlighting the sector’s economic contribution, this move is a welcome boost for Singapore’s digital and green ambitions.”

    Singapore remains Southeast Asia’s largest data centre hub, with over 1061MW of capacity currently in operation. The recently established Singapore–Malaysia Data Centre Economic Zone represents a strategic and pragmatic partnership, allowing Singapore to maintain its role as the “hub of the digital infrastructure wheel”, while leveraging Malaysia’s land and energy availability to fuel the next phase of regional growth.

    Tan See Leng, Singapore’s minister of energy, science and technology, stated that Jurong Island would be a global test bed for new low-carbon and technologies.

    Nicholas Hanna, an expert in technology ventures at Pinsent Masons, said: “The required energy consumption of the newly announced data centre park, along with the commitment that it must meet standards and predominantly utilise green energy, raises some possible challenges about where the power generation will come from, how it will be distributed, and how to compete against neighbouring countries on price. Singapore, as a nation, is no stranger to accepting challenges and turning them into world class solutions. This should be no different.”

    “Large, hyperscale data centres can have power demands of more than 100MW, which will require a significant expansion of power generation,” he said.

    “This is an opportunity for businesses looking to continue to expand their footprint in Singapore.”

    Roughly a third of Singapore’s greenhouse gas emissions are from the refining and petrochemical industries, and the country has committed to reducing greenhouse gas emissions by between 45 million and 50 million tonnes by 2035, in line with reaching net zero emissions by 2050.

    David Clinch, an expert in energy infrastructure at Pinsent Masons, said: “Singapore is projecting forward and further innovating for the next phases of the development of Jurong Island, whilst taking into account how that interacts with the government’s sustainability targets. This is another exciting opportunity for businesses to be part of that development and work with the government to achieve those targets.”

    Mark Tan, an expert in commercial law at Pinsent Masons, said: “Jurong Island’s upcoming data centre project marks a pivotal step in Singapore’s digital and sustainability journey.” 

    “Designed to deliver up to 700MW of capacity with hydrogen-ready power and advanced tropical cooling, it appears to set a new benchmark for low-carbon infrastructure,” he said.

    “This initiative not only strengthens Singapore’s AI and cloud capabilities but also creates further engineering and technology jobs, reinforcing Singapore’s position as a global hub for green innovation.”

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  • China will lift some tariffs on US agricultural goods from Nov. 10

    China will lift some tariffs on US agricultural goods from Nov. 10

    The Chinese Finance Ministry announced on Wednesday, “China will lift some tariffs on US agricultural goods from November 10.

    Additional takeaways

    China to suspend 24% US tariffs for a year.

    China to maintain 10% US tariffs.

    No further details are provided about the same.

    Market reaction

    The US Dollar Index (DXY) is unable to find any inspiration from these comments, trading modestly flat on the day near 100.20, as of writing.

    US-China Trade War FAQs

    Generally speaking, a trade war is an economic conflict between two or more countries due to extreme protectionism on one end. It implies the creation of trade barriers, such as tariffs, which result in counter-barriers, escalating import costs, and hence the cost of living.

    An economic conflict between the United States (US) and China began early in 2018, when President Donald Trump set trade barriers on China, claiming unfair commercial practices and intellectual property theft from the Asian giant. China took retaliatory action, imposing tariffs on multiple US goods, such as automobiles and soybeans. Tensions escalated until the two countries signed the US-China Phase One trade deal in January 2020. The agreement required structural reforms and other changes to China’s economic and trade regime and pretended to restore stability and trust between the two nations. However, the Coronavirus pandemic took the focus out of the conflict. Yet, it is worth mentioning that President Joe Biden, who took office after Trump, kept tariffs in place and even added some additional levies.

    The return of Donald Trump to the White House as the 47th US President has sparked a fresh wave of tensions between the two countries. During the 2024 election campaign, Trump pledged to impose 60% tariffs on China once he returned to office, which he did on January 20, 2025. With Trump back, the US-China trade war is meant to resume where it was left, with tit-for-tat policies affecting the global economic landscape amid disruptions in global supply chains, resulting in a reduction in spending, particularly investment, and directly feeding into the Consumer Price Index inflation.

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  • Nvidia joins $2 billion India deep tech alliance to mentor AI startups

    Nvidia joins $2 billion India deep tech alliance to mentor AI startups

    Co-founder and CEO of Nvidia Jensen Huang spoke to journalists during a trip to Beijing in July.

    Picture Alliance | Picture Alliance | Getty Images

    Nvidia will help train and mentor emerging deep tech startups in India as a founding member of a $2 billion investment alliance, deepening its presence in the world’s third-largest startup ecosystem.

    The U.S. chipmaker has joined the India Deep Tech Alliance (IDTA) — a group of private equity and venture capital investors pledging $2 billion for deep tech investments — as a founding member. Deep tech startups are an umbrella term for emerging companies in semiconductors, space, AI, biotech, robotics, and energy.

    The world’s most valuable company will offer technical talks and training through its Nvidia Deep Learning Institute to emerging startups in India.

    Nvidia wants to “provide guidance on AI systems, developer enablement, and responsible deployment, and to collaborate with policymakers, investors, and entrepreneurs,” Vishal Dhupar, Nvidia’s managing director of South Asia, said.

    Nvidia did not disclose any financial investment, timeline, or training targets, and did not immediately respond to a CNBC request for comment.

    “Nvidia’s depth of expertise in AI systems, software, and ecosystem-building will benefit our network of investors and entrepreneurs,” said Sriram Viswanathan, founding executive council member of the IDTA.

    He told CNBC that the pace of innovation is accelerating in India and there could be a “significant number of Indian deep tech companies of global repute” in the next five years.

    The Indian government is also actively encouraging research and innovation in the deep tech space through major initiatives, including over 100 billion rupees ($1.1 billion USD) under its AI Mission and a separate 1 trillion rupees ($11.2 billion) Research, Development and Innovation Scheme Fund targeting deep tech companies.

    On Monday, Indian Prime Minister Narendra Modi announced that the country will host the AI Impact Summit in February next year.

    The event is likely to see the participation of heads of state and top policymakers, along with business leaders such as Jensen Huang, chief executive officer of NVIDIA, and Demis Hassabis, CEO of Google DeepMind.

    Nvidia’s commitment in India coincides with rising global interest in India’s AI market, where OpenAI counts the country as its second-largest user base. U.S. rivals are also deepening ties: Google recently pledged $15 billion to build an AI hub in the southern city of Visakhapatnam.

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  • France investigates Shein and Temu after sex doll scandal

    France investigates Shein and Temu after sex doll scandal

    Online retailers Shein, Temu, AliExpress and Wish are being investigated in France in relation to the offence of enabling minors to access pornographic content on their platforms, the Paris prosecutor said on Tuesday.

    The country’s consumer watchdog had reported the four firms to the prosecution service on Sunday after raising concerns about the sale of childlike sex dolls on Shein’s platform over the weekend.

    The Paris prosecutor’s office told the BBC that the platforms are being investigated over violent, pornographic or “undignified messages” that can be accessed by minors.

    The BBC has contacted the companies for comment.

    Shein and AliExpress are also under investigation over the dissemination of content related to children that are of a pornographic nature, the office said.

    The cases have been referred to Paris’ Office des Mineurs, which oversees the protection of minors, the prosecution service added.

    On Monday, Shein said it had banned the sale of all sex dolls on its platform worldwide. The Singapore-based retailer also said that it would permanently block all seller accounts related to the illegal sale of the childlike dolls and set stricter controls on its platform.

    The French consumer watchdog, the Directorate General for Competition, Consumer Affairs and Fraud Control, had said the sex dolls’ description and categorisation left “little doubt as to the child pornography nature” of the products.

    The scrutiny of Shein comes as the company, which was founded in China, prepares for the opening on Wednesday of its first permanent physical outlet in France .

    Protesters have been seen gathered in front of the Paris department store where Shein is set to open the outlet.

    Shein plans to open outlets in other French department stores in cities including Dijon, Reims and Angers.

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  • Stonepeak to Launch ASX-Listed Infrastructure Debt Note

    Stonepeak to Launch ASX-Listed Infrastructure Debt Note

    Stonepeak-Plus INFRA1 Note expected to list on ASX on December 3, 2025 under the ticker code “SPPHA”

    NEW YORK & SYDNEY – November 4, 2025 – Stonepeak (“Stonepeak” or the “Company”), a leading global alternative investment firm specializing in infrastructure and real assets, today announced its intention to launch Stonepeak-Plus INFRA1 (“Stonepeak-Plus INFRA1 Note” or the “Note”), an unsecured, deferrable, redeemable, floating rate infrastructure-backed debt security expected to be listed on the Australian Securities Exchange (“ASX”) on December 3, 2025 under the ticker code “SPPHA.”

    The Stonepeak-Plus INFRA1 Note will provide Australian investors access to regular monthly income generated through a curated portfolio of high-quality infrastructure debt assets. Debt will be sourced predominantly from critical infrastructure assets in the transportation and logistics, energy and energy transition, digital, and social infrastructure sectors in Australia, New Zealand, and other markets. The Interest Rate applicable to Stonepeak-Plus INFRA1 Notes is a benchmark rate of BBSW (1 month) + a margin of 3.25% per annum which accrues on a monthly basis, and the Note will have a target repayment date six years after the issue date.

    Stonepeak has already secured over A$300 million in cornerstone investments for the Note, reaching its target and reflecting strong initial demand.

    “Infrastructure businesses have historically exhibited lower default rates compared to corporate debt, making infrastructure debt an especially powerful portfolio diversification tool for investors due to its stable and predictable nature. However, infrastructure debt has historically been a challenging asset class for investors to access at scale. The proposed launch of Stonepeak-Plus INFRA1 aims to solve this for Australian investors while giving them the opportunity to invest behind some of the most compelling tailwinds in infrastructure today,” said Andrew Robertson, Senior Managing Director and Head of Australia and New Zealand Private Credit at Stonepeak, the largest independent infrastructure investor globally. “We look forward to leveraging Stonepeak’s extensive experience, deep sector specialization, and strong industry relationships to bring a quality, investment-grade portfolio of infrastructure debt assets to our investors.”

    “We have long recognized the compelling opportunities in the credit space, and we are excited to be broadening access to the asset class through the launch of this Note,” said Stonepeak Co-President Jack Howell. “Since we began investing in infrastructure debt in 2018, we have continued to thoughtfully expand the Stonepeak Credit team and its offerings. The proposed launch of Stonepeak-Plus INFRA1 reflects another milestone, and builds on our success investing across the capital stack into world-class, critical infrastructure on behalf of our investors.”

    Today, Stonepeak Credit includes nearly 30 investment professionals and over 85 investments in its portfolio, and manages approximately A$2.9 billion in assets. Notably, this year Stonepeak completed the acquisition of Boundary Street Capital, a leading specialist private credit investment manager focused on the digital infrastructure, enterprise infrastructure software, and technology services sectors in the lower middle market. The launch of the Note also reflects the continued growth of Stonepeak+, Stonepeak’s dedicated wealth solutions platform.

    E&P Capital, Westpac, Morgans, FIIG Securities, MST, and Shaw and Partners are serving as joint lead managers to Stonepeak, with Corrs Chambers Westgarth acting as legal adviser.

    About Stonepeak Credit

    Stonepeak Credit is the credit investing arm of Stonepeak, a leading alternative investment firm specializing in infrastructure and real assets with approximately A$121.1 billion (USD$79.9 billion) of assets under management. Stonepeak Credit targets credit investments across the transportation and logistics, energy and energy transition, digital infrastructure, and social infrastructure sectors that provide essential services with downside protection, high barriers to entry and visible, recurring revenue generation. It seeks to provide capital solutions that are flexible across the capital structure while generating cash yield through majority senior secured credit investments.

    Stonepeak is headquartered in New York with offices in Houston, Washington, D.C., London, Hong Kong, Seoul, Singapore, Sydney, Tokyo, Abu Dhabi, and Riyadh. For more information, please visit www.stonepeak.com.

    Contacts

    Kate Beers / Maya Brounstein
    corporatecomms@stonepeak.com
    +1 (646) 540-5225

    Jack Gordon
    jack.gordon@sodali.com
    +61 478 060 362

    Important Notices

    Stonepeak-Plus Infra Debt Limited (ACN 692 150 253) (Issuer) is the issuer of the unsecured, deferrable, redeemable, floating rate notes known as the Stonepeak-Plus INFRA1 Notes (Notes) which are intended to be quoted on the ASX. The Notes are redeemable by, and the interest is deferrable by, the Issuer. Unless otherwise specified, any information contained in this material is current as at the date of publication and has been prepared by the Issuer.

    The offer of Notes is made by a prospectus (Prospectus) which is available, along with a target market determination (TMD), at stonepeakplus.com.au/INFRA-1. You must read the Prospectus before making a decision to acquire the Notes. It is important for you to consider the Prospectus and whether you are in the target market in the TMD in deciding whether to invest.  You will need to complete the application form accompanying the Prospectus. No cooling off rights apply to an investment the Notes.

    The Issuer has appointed EQT Australia Pty Ltd (ACN 111 042 132) (Authorised Intermediary) as authorised intermediary to make offers to arrange for the issue of Notes under the prospectus, pursuant to section 911A(2)(b) of the Corporations Act 2001 (Cth). The Authorised Intermediary is an Australian financial services representative (number 1262369) of Equity Trustees Limited (ACN 004 031 298; AFSL 240975). Stonepeak-Plus Infra Debt Management Pty Ltd (ACN 691 462 067, authorised representative no. 001318081) (Manager) provides investment management and other services to the Issuer.

    The Issuer is not licensed to provide financial product advice in relation to the Notes. The information provided is intended to be general in nature only. This material has been prepared without taking into account any person’s objectives, financial situation or needs.  Any person receiving the information in this material should consider the appropriateness of the information, in light of their own objectives, financial situation or needs before acting.

    Past performance is not a reliable indicator of future performance. Investments in the Notes are subject to investment risk, including possible delays in payment and loss of interest or principal invested. The Notes and their performance are not guaranteed by any member of the Stonepeak Group or any other person. The Notes are not bank deposits.

    The material has not been independently verified.  No reliance may be placed for any purpose on the material or its accuracy, fairness, correctness or completeness.  To the fullest extent permitted by law, the Issuer, the Manager, the Authorised Intermediary or any other member of the Stonepeak Group and their respective associates and employees shall have no liability whatsoever (in negligence or otherwise) for any loss howsoever arising from any use of this material or otherwise in connection with the information.

    A minority part of the portfolio is expected to comprise other debt investments that are not infrastructure related, as explained in the Prospectus. The above AUM is as of June 2025 inclusive of subsequent committed capital. Certain of these investments have signed but are pending close, and there can be no assurance they will close or that if they close that it will be on the terms currently agreed. The AUM, employee and investment information relate to Stonepeak Group, and not the Issuer.

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  • New Clinical Data on the Efficacy of Antiviral Treatments for Post-COVID-19 Condition| SHIONOGI

    OSAKA, Japan, November 5, 2025 – General Incorporated Association Tokushukai (Location: Chiyoda-ku, Tokyo; Chairperson of the Board: Shinichi Higashiue, M.D.; hereinafter “Tokushukai Medical Group”) and Shionogi & Co., Ltd. (Head Office: Osaka, Japan; Chief Executive Officer: Isao Teshirogi, Ph.D.; hereafter “Shionogi”) announced new clinical data from the ANCHOR study, a large-scale post-marketing clinical study conducted by Tokushukai Medical Group in patients diagnosed with COVID-19. The primary endpoint results were presented at the 8th ISRV-AVG Meeting and 3rd IMRP held in Singapore (September 17–20, 2025), and secondary endpoint results were presented at APCCMI 2025 in Thailand (November 2–4, 2025).

     

    The World Health Organization (WHO) defines PCC as occurring in individuals with a history of probable or confirmed SARS-CoV-2 infection, typically around three months after the onset of COVID-19, with symptoms lasting for at least two months and not explainable by an alternative diagnosis1. Common symptoms include fatigue, shortness of breath, loss of taste or smell, cognitive dysfunction but also others which generally have an impact on everyday functioning2. PCC is a significant challenge not only in Japan but globally. However, evidence supporting the effectiveness of antiviral in preventing these symptoms has been limited. In response, the Tokushukai Medical Group conducted a large-scale clinical study (ANCHOR study) targeting outpatients diagnosed with COVID-19. This study evaluated the impact of antiviral use on the PCC.

     

    This multi-center, nationwide, prospective observational study enrolled outpatients aged ≥12 years diagnosed with COVID-19 at 51 Tokushukai Group hospitals across Japan. As a collaborative research partner, Shionogi contributed to the execution of this study.

     

    The clinical study presented this time included approximately 9,000 cases enrolled between February 1 and October 31, 2024. The primary endpoint of this study, “the incidence of PCC,” in the antiviral and non-antiviral group, defined as persistence of any of five pre-specified symptoms (fatigue, dyspnea or respiratory distress, cough, smell disorder, taste disorder) on both Days 28 and 84, excluding symptoms not attributed to COVID-19. The incidence of post-COVID-19 symptoms was then evaluated based on this definition. The incidence of PCC was approximately 26% in the non-antiviral group (N=5,518) and approximately 24% in the antiviral group (N=2,181, combined group of ensitrelvir, nirmatrelvir/ritonavir, and molnupiravir). Antiviral treatment significantly reduced the risk by about 14% (adjusted risk ratio: 0.86 [95% CI: 0.78–0.93]; P < 0.001). For ensitrelvir alone, the risk was also significantly reduced by about 14% compared to non-antiviral treatment (adjusted risk ratio: 0.86 [95% CI: 0.79–0.95]; P = 0.002).

     

    For the secondary endpoint, “Frequency of COVID-19–related re-consultations within 28 days,” no significant risk reduction was observed in the overall antiviral group compared to the non-antiviral group (adjusted risk ratio: 0.93 [95% CI: 0.83–1.04]; P = 0.266). However, ensitrelvir alone showed a significant 12% reduction in re-visit risk (adjusted risk ratio: 0.88 [95% CI: 0.78–0.99]; P = 0.030).

     

    These findings suggest that oral antiviral treatment may contribute to improving acute-phase symptoms, reducing the incidence of PCC, and potentially lowering re-visit frequency.

     

    “Managing PCC remains a major unmet medical need. We are pleased that the ANCHOR study results indicate that antiviral treatment during the acute phase may help prevent the onset of PCC. This study represents an important step toward new directions in COVID-19 treatment and is expected to inform clinical decision-making and long-term health management,” said Dr. Makoto Hibino, MD, principal investigator of this study, Deputy Director of Shonan Oiso Hospital, and Chair of the Tokushukai Respiratory Committee.

     

    In the “Guidelines for the Clinical Management of COVID-19 issued by five academic societies” published on October 17, 2025, it is stated that “the fundamental principle of clinical care for infectious diseases, particularly viral infections, is early diagnosis and early treatment. This approach may help prevent severe illness, alleviate symptoms, and enable early return to social activities for individuals, while also reducing the burden on society by preventing widespread transmission and decreasing the number of hospitalized patients.”3

    Based on these principles outlined in the guidelines, Tokushukai Group and Shionogi will continue to collaborate in accumulating evidence related to COVID-19 and delivering it back to clinical practice.

     

     

    About ANCHOR Study

    The purpose of ANCHOR study is to collect information of the clinical course of patients with COVID-19 treated at Tokushukai hospitals with and without antiviral drugs and to explore the clinical course in the acute phase, the frequency of severe disease, and frequency of PCC by the treatment, after adjusting by patient background including risk factor(s) and symptoms at the time of registration. In this study, Shionogi is participating as a collaborative research partner.

     

    About Tokushukai Medical Group

    Tokushukai Medical Group philosophy is “All livin beings are created equal”. Under this philosophy, we continuously strive for realizing “Anybody in the society is to receive the best possible medical care in anywhere, at whenever necessary”. From Emergency Medical Care, an origin of medical care, to preventive health care, chronic medical care and advanced medical care, we provide the optimal medical care. For more information on Tokushukai Medical Group, please visit https://www.tokushukai.or.jp/en/

     

    About Shionogi & Co., Ltd.

    For over 60 years, Shionogi has been engaged in the research and development of infectious disease treatments. Identifying ” Protect people from the threat of infectious diseases” as a material issue (materiality) to be addressed, the company is working towards the realization of comprehensive infectious disease care. As a leading company in the field of infectious diseases, Shionogi is strengthening its initiatives, including collaborations with external partners, to provide healthcare solutions to a broader audience and continuously address a wide range of infectious diseases. For more information on Shionogi & Co., Ltd., please visit https://www.shionogi.com/global/en

     

    Forward-Looking Statements

    This announcement contains forward-looking statements. These statements are based on expectations in light of the information currently available, assumptions that are subject to risks and uncertainties which could cause actual results to differ materially from these statements. Risks and uncertainties include general domestic and international economic conditions such as general industry and market conditions, and changes of interest rate and currency exchange rate. These risks and uncertainties particularly apply with respect to product-related forward-looking statements. Product risks and uncertainties include, but are not limited to, completion and discontinuation of clinical trials; obtaining regulatory approvals; claims and concerns about product safety and efficacy; technological advances; adverse outcome of important litigation; domestic and foreign healthcare reforms and changes of laws and regulations. Also for existing products, there are manufacturing and marketing risks, which include, but are not limited to, inability to build production capacity to meet demand, lack of availability of raw materials and entry of competitive products. The company disclaims any intention or obligation to update or revise any forward-looking statements whether as a result of new information, future events or otherwise.

     

    For Further Information, Contact:

    SHIONOGI Website Inquiry Form: https://www.shionogi.com/global/en/contact.html

     

    Reference List:

    1.       WHO, Post COVID-19 conditions; https://www.who.int/teams/health-care-readiness/post-covid-19-condition

    2.       Ministry of Health, Labour and Welfare (Japan), Guidelines for COVID-19 Clinical Management – Supplement: Management of Post-COVID-19 Conditions, Version 3.1, 2025; https://www.mhlw.go.jp/content/10900000/001422904.pdf

    3.       Guidelines for the Clinical Management of COVID-19 issued by five academic societies 2025

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  • Oil prices fall amid broader market selloff, gains in US crude stockpiles – Reuters

    1. Oil prices fall amid broader market selloff, gains in US crude stockpiles  Reuters
    2. API Reports Sizeable Crude Oil Build  Crude Oil Prices Today | OilPrice.com
    3. The Commodities Feed: Bullish EIA release pushes oil higher  ING Think
    4. At the European session’s beginning, WTI oil rises to $61.24, while Brent remains steady at $64.58  VT Markets
    5. Oil Extends Drop After Report Points to Jump in US Inventories  Bloomberg

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  • MHI and ICM Form Strategic Alliance to Advance Ethanol Dehydration Efficiency

    MHI and ICM Form Strategic Alliance to Advance Ethanol Dehydration Efficiency

    The collaboration focuses on integrating MHI’s Mitsubishi Membrane Dehydration System (MMDS™) with ICM’s bioethanol process design. Together, the companies aim to increase efficiency in ethanol production by reducing energy consumption, enhancing process reliability, and supporting the industry’s efforts to lower carbon intensity.

    MHI recently achieved more than 99.5 vol.% ethanol purity using its MMDS™ at a pilot plant installed at the Nagasaki Carbon Neutral Park, located within the company’s Nagasaki District Research & Innovation Center. Early pilot results indicate a significant reduction in energy consumption compared to conventional dehydration methods. Further testing and validation are planned as both companies prepare for the next phase of development and commercial implementation.

    To ensure the technology’s long-term performance and integration success, MHI and ICM are planning two key validation programs: a fouling test and a demonstration test. The fouling test will assess the membrane’s durability and resistance to impurities in the ethanol stream, ensuring stable operation over time. The demonstration test will validate full-scale performance in a production environment, confirming efficiency, reliability, and seamless integration within ICM’s process design.

    Ethanol dehydration is one of the most energy-intensive steps in bioethanol production. By replacing the traditional Pressure Swing Adsorption (PSA) method with a molecular sieve separation method, MMDS™ enables high-efficiency manufacturing while significantly reducing energy use and operational costs. Because MMDS™ enables separation in the liquid phase, the system can also be designed more compactly, reducing the equipment footprint and simplifying installation.

    “Through this collaboration with MHI, we’re exploring new approaches to ethanol dehydration that can further improve efficiency and reliability in ethanol production,” said Shaun Hubler, Director of Technology Commercialization at ICM, Inc. “The pilot results are very promising, and we look forward to building on them as we move toward full commercial deployment.”

    “This partnership represents an important step toward realizing MHI’s vision for carbon-neutral industrial solutions,” stated Fumitaka Miyashige, Business Manager of MMDS™ project at MHI. “Working with ICM allows us to bring this advanced separation technology to the global renewable fuels market.”

    Further testing is scheduled to begin in Q2 2026, marking an important step toward the technology’s first commercial installation. Both companies view this alliance as a long-term collaboration to advance efficiency, sustainability, and competitiveness of the global bioethanol industry.

     

    About ICM, Inc.
    Established in 1995 and headquartered in Colwich, Kansas, with a regional office in Brazil, ICM provides innovative technologies, solutions, and services to sustain agriculture and to advance renewable energy, including ethanol and feed technologies that will increase the supply of world protein. By providing proprietary process technologies to over 110 facilities globally with a combined annual production of approximately 8.8 billion gallons of ethanol and 25 million tons of distiller grains, ICM has become a world leader in biorefining technologies. For additional information, visit icminc.com.

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