Category: 3. Business

  • U startup tackles e-waste with degradable materials – @theU

    U startup tackles e-waste with degradable materials – @theU

    Reposted from the Technology Licensing Office.

    When consumers discard electronic devices, they often end up in U.S. landfills or are exported overseas for processing. EnduraCure, a University of Utah startup, is addressing this sustainability challenge by developing high-performance polymer substrates that can be chemically degraded. The goal is to use these materials in electronics so they can be more easily processed to recover valuable metals contained in their circuitry.

    According to the Environmental Protection Agency, electronic waste is one of the fastest-growing environmental problems in the world, posing significant risks both to workers who handle these materials and to the environments where they’re disposed.

    Yet these materials contain precious metals found in circuits that have inherent value for reuse, but current disposal processes often leave them in landfills. Toxic materials, such as lead, mercury, cadmium and arsenic, can leach into the environment and expose disposal workers to high levels of contaminants. In response, the National Science Foundation and related organizations have encouraged researchers to develop reusable and reclaimable materials.

    Lightening the load on landfills

    EnduraCure is answering that call. Their technology uses a photocured polymerization process to create flexible substrates that match the durability of conventional materials during use but can be broken down in a mild chemical bath at end-of-life—recovering valuable components in the process.

    “It’s all about making these products degradable by design,” said EnduraCure CEO Dennis Pruzan, a former U engineering graduate student. “We’re pushing towards a circular economy and reducing loads on landfills.”

    The company’s initial focus is on flexible electronic substrates and encapsulants—materials used in medical sensors, smart packaging, and wearable devices. These applications demand both performance and flexibility, making them ideal candidates for EnduraCure’s sustainable alternative to conventional nonrecyclable materials.

    The company originated in the  Wang Research Group in the Price College of Engineering, where sustainable polymers are the central research focus under the leadership of Chen Wang, an assistant professor in the Department of Materials Science & Engineering. Pruzan completed his Ph.D. in materials science in 2018, then spent several years in industry working on carbon fiber products at DPS Skis. Wang recruited him back to his lab as a research associate, and when EnduraCure needed dedicated leadership, Pruzan’s combination of academic training and industry experience made him a natural fit to take the lead.

    “One of the things I admire most about the way Chen operates his lab is that it’s with an eye on translational research,” Pruzan explained. “We don’t want to do research for the sake of doing research. We want to do research that has economic value.”

    In recent months, Pruzan and his team have shifted their work from the lab into a separate business and commercialization space, seeking both funding and collaborators as they establish themselves in this new environment.  The company recently received the National Science Foundation’s Phase 1 Small Business Technology Transfer (STTR) award, funding continued research and commercialization efforts.

    A university-supported funding pipeline

    To bridge the funding gap between academic research and commercialization, EnduraCure secured an Ascender Grant from the Technology Licensing Office—stopgap funding that proved critical while the team pursued the STTR.

    Pruzan also participated in the NSF I-Corps program through the U, an intensive customer discovery process that reshaped how the team thought about their market. The team’s successful pursuit of the NSF STTR Phase 1 Award provides funding to establish themselves as a company and move beyond the university research environment—an important milestone in their translational research journey.

    In coming months, the EnduraCure team plans to seek out a manufacturing partner—ideally an electronics company with whom they can demonstrate environmentally sustainable and cost-effective ways to degrade used devices and recover valuable materials at scale. Success would position the company for Phase 2 NSF funding.

    “A big part of my job right now is making connections and getting to know people in the landscape of entrepreneurship and small businesses,” Pruzan said. “It’s very clear that Utah has a wealth of resources to make those connections.”

    Get involved

    • For U of U researchers: Interested in exploring commercialization for your own work? The Ascender Grant and I-Corps program help bridge the gap between lab discoveries and market applications.
    • For industry partners: EnduraCure is actively seeking manufacturing partners in flexible electronics, medical devices, and consumer electronics. Contact the Technology Licensing Office to learn more.

    Related news: New substrate for flexible electronics could help combat e-waste

    Continue Reading

  • Decision-making components and times revealed by the single-trial electroencephalogram

    Decision-making components and times revealed by the single-trial electroencephalogram

    Making a decision involves several information processing steps within the time from the presentation of a stimulus to the response. The total time required for the completion of each of these processing steps is the reaction time (RT). Specific processes differ between experimental paradigms, but a minimal set that seems to be agreed upon involves encoding of the choice-relevant features of the stimuli, followed by weighting the evidence for each choice, and initiating a response (Donders, 1868; Ratcliff and McKoon, 2008; Zylberberg et al., 2011; Luce, 1986). Despite being an almost two century-old problem (Helmholtz, 1850), it is unclear how the RT emerges from these putative components.

    The answer to this problem has first been hampered by the relatively poor information gained from RT and response-accuracy data alone. Co-registering physiological signals can clarify and extend conclusions about information processing steps in the RT (Turner et al., 2017). Evidence for the putative components that make up RT has been found by registering the electroencephalogram (EEG) during decision tasks. First, a negative deflection in occipital electrodes happening around 200ms after the presentation of a choice, the N200, has been associated with visual encoding of the choice elements by participants (Nunez et al., 2019; Ritter et al., 1979). Second, EEG data has shown that the weighting of evidence toward the alternatives is associated with a positive voltage developing over centro-parietal electrodes after early visual potentials (Kutas et al., 1977). Computational models of decision-making explain the experimental effects observed on these centro-parietal components as an evidence accumulation mechanism (O’Connell et al., 2012; Kelly et al., 2021). Lastly, a component preceding the response has been shown to lateralize with the side of the executed response (Coles et al., 1985). This lateralized readiness potential (LRP) has later been described as arising from an accumulation-to-bound mechanism describing the decision to produce a movement (Schurger et al., 2012).

    However, the knowledge gained on the nature and latencies of cognitive processes within the stimulus-response interval from such electrophysiological components is limited by the low signal-to-noise ratio of classical neural measurements. To improve the SNR, researchers usually rely on information derived from the averaging of these signals over many trials. Unfortunately, averaging time-varying signals will result in an average waveform that misrepresents the underlying single-trial events (Luck, 2005; Borst and Anderson, 2024). In the case of decision-making, several studies have shown wide trial-by-trial variation of the timing of cognitively relevant neural events (Vidaurre et al., 2019; Smyrnis et al., 2012; Weindel et al., 2021; Weindel, 2021). Furthermore, averaged components are further distorted by the fact that multiple cognitive processes and associated EEG components are typically present within trials and overlap in time between trials (Woldorff, 1993), forcing researchers to study physiological components in isolation. A few studies have been able to simultaneously investigate multiple EEG components in decision-making using single-trial approaches. As an example, Philiastides et al., 2006 used a classifier on the EEG activity of several conditions to show that the strength of an early EEG component was proportional to the strength of the stimulus, while a later component was related to decision difficulty and behavioral performance (see also Salvador et al., 2022; Philiastides and Sajda, 2006). Furthermore, the authors interpreted that a third EEG component was indicative of the resource allocated to the upcoming decision given the perceived decision difficulty. In their study, they showed that it is possible to use single-trial information to separate cognitive processes within decision-making. Nevertheless, their method requires separate classifiers for each component of interest, limiting the analysis to existing theory of distinct components.

    One potential solution mixing both behavior and multivariate analysis of single-trial neural signal to achieve single-trial resolution has emerged through the development of the hidden multivariate methods (Weindel et al., 2024; Anderson et al., 2016). These methods model the neural data of each trial as a sequence of short-lived multivariate cortex-wide events, repeated at each trial, whose timing varies on a trial-by-trial basis and define the RT. In the case of EEG, it is assumed that any cognitive step involved in the RT is represented by a specific topography recurring across trials. The time jitter in the topography is accounted for by estimating, for each of these events, a trial-wise distribution where the expected time of the peak of the topography is given by the time distribution of the previous event’s peak and the expected time distribution of the current event. By constraining, through the recorded behavior, the search for trial-shared sequential activations in the EEG during estimated ranges of time, the hidden multivariate pattern (HMP) model (Weindel et al., 2024) provides an estimation of the number of events and their single-trial latency during each trial. Previous similar approaches have shown that different information processing steps can be extracted from the EEG in a wide range of tasks (Berberyan et al., 2021; Zhang et al., 2018; Anderson et al., 2016; Anderson et al., 2018; Krause et al., 2024). Building on previous work (van Maanen et al., 2021), we expect that the EEG data of a decision-making task will be decomposed into task-relevant intervals indexing the information processing steps in the RT. In the current study, we combine this single-trial modeling strategy with strong theoretical expectations regarding the impact of experimental manipulations on the latent information processing steps during decision-making.

    The task of the participants was to answer which of two Gabor patches flanking a fixation cross displayed the highest contrast (Figure 1, top panel). On a trial-by-trial basis, we manipulated the average contrast of both patches but kept the difference between them constant (see the two example trials in Figure 1, one with an average contrast of 5%, and one with an average contrast of 95%, both with a difference of 5%). We hypothesize that this contrast manipulation generates two opposing predictions on encoding and decision processes (Weindel et al., 2022) associated with two of the oldest laws in psychophysics: Piéron’s law (Piéron, 1913) and Fechner’s law (Fechner, 1860).

    Contrast manipulation used in the experiment.

    Top shows two example stimuli illustrating minimum (left) and maximum (right) contrast values. The bottom panel shows the prediction for the Piéron, the Fechner, and the linear laws for all contrast levels (C) used in the study for a fixed set of parameters. The y-axis refers to the time predicted by each law given a contrast value (x-axis) and the chosen set of parameters. α, β, and ν are respectively the estimated participant-specific intercept, slope, and exponent for the three laws. The Fechner diffusion model additionally includes nondecision and decision threshold parameters (see ‘Materials and methods’).

    Piéron’s law predicts that the time to perceive the two stimuli (and thus the choice situation) should follow a negative power law with the stimulus intensity (Figure 1, green curve). In contradistinction, Fechner’s law states that the perceived difference between the two patches follows the logarithm of the absolute contrast of the two patches (Figure 1, yellow curve). As the task of our participants is to judge the contrast difference, Piéron’s law should predict the time at which the comparison starts (i.e., the stimuli become perceptible), while Fechner’s law should implement the comparison, and thus decision, difficulty. Given that Fechner’s law is expected to capture decision difficulty, we connected this law to evidence accumulation models by replacing the rate of accumulation with Fechner’s law in the proportional rate diffusion model of Palmer et al., 2005. This linking with an evidence accumulation model further allows connecting the RT to the proportion of correct responses. To test the generalizability of our findings and allow comparison to standard decision-making tasks, we also included a speed–accuracy manipulation by asking participants to either focus on the speed or the accuracy of their responses in different experimental blocks.

    Continue Reading

  • Valneva and Serum Institute of India Announce Discontinuation of Chikungunya Vaccine License Agreement

    Saint-Herblain (France), Pune, (India), December 31, 2025 – Valneva SE (“Valneva” or “the Company”), a specialty vaccine company, and Serum Institute of India (SII), a Cyrus Poonawalla Group company today announced that they have mutually agreed to discontinue their license agreement for Valneva’s single-shot chikungunya vaccine.

    To access the full release, please click on the PDF below.

    Continue Reading

  • California advances Jobs First agenda, expands career pathways and worker protections statewide

    California advances Jobs First agenda, expands career pathways and worker protections statewide

    “Behind every investment are people – workers gaining new skills, families recovering after disasters, and communities building their futures,” said California Secretary of Labor Stewart Knox. “This year, California strengthened career pathways, protected workers’ rights, and brought services directly to communities across the state.”

    Jobs First: growing jobs across California

    The Governor launched the California Jobs First Council, bringing state agencies together to coordinate economic development, workforce, education, and infrastructure investments around a shared strategy for regional job growth. The Council aligns statewide action with 13 region-specific plans developed by local partners to reflect local priorities and labor-market needs.

    In August, California Jobs First unveiled an $80 million investment to support 23,000 jobs and 11 projects, bolstering economic progress in communities and industries throughout the state.

    Through California Jobs First, the state is training workers and supporting job creation across all 13 economic regions, targeting high-growth industries such as construction, healthcare, education, advanced manufacturing, clean energy, aerospace and defense, life sciences, and agtech.

    Master Plan on Career Education: expanding apprenticeships and skills-based pathways

    In 2025, California continued to strengthen efforts to connect education, workforce training, and employer needs to create a variety of pathways to good-paying careers. The state moved closer toward Governor Newsom’s goal of serving 500,000 registered apprentices by 2029, serving more than 233,000 Californians in registered apprenticeships and, with interagency support, over 600,000 served through earn and learn programs since 2019. In alignment with the Master Plan on Career Education, the Division of Apprenticeship Standards (DAS) expanded registered apprenticeship and pre-apprenticeship programs statewide by supporting new and expanded programs across traditional and emerging industries. California investments include $15 million to advance 29 apprenticeship programs for young people entering the workforce, and $30 million for Apprenticeship Innovation Funding which benefited 70 apprenticeship programs in expanding sectors, such as health care, advanced manufacturing, and education.

    The Employment Training Panel complemented this work by approving 299 training contracts in 2025, supporting 70,544 workers through employer-driven training programs, including $25 million to train more than 22,000 workers through apprenticeship programs that focused on training women, justice-involved individuals, veterans, and people transitioning from unemployment or low-paying jobs.

    Clean up and recovery after the Los Angeles firestorms

    In response to the devastating firestorms in Los Angeles, Governor Newsom coordinated a rapid, multi-agency response, which included a focus on economic recovery, reemployment, and worker health and safety.

    The State delivered $20 million in aid to the LA region to support dislocated workers and critical recovery and rebuilding efforts, with a $10 million Department of Labor National Dislocated Worker Grant for humanitarian aid and cleanup through temporary jobs, and another $10 million for the Los Angeles County Department of Economic Opportunity to provide transitional jobs, training, and supportive services for displaced workers.

    Through California Jobs First, the state awarded $3 million to the LA Jobs First Collaborative to support recovery efforts in Altadena and Pacific Palisades, including assistance for local small businesses and tourism-dependent employers and ongoing economic impact reporting and analysis to guide rebuilding.

    The Employment Development Department (EDD) activated disaster response protocols to help impacted workers access unemployment insurance and disaster-related assistance, including direct support navigating claims.

    At the same time, the Department of Industrial Relations (DIR) prioritized worker protection during cleanup and rebuilding. Cal/OSHA issued wildfire smoke and heat-safety guidance, conducted employer outreach, and enforced safety standards to protect vulnerable workers operating in hazardous conditions.

    The Labor and Workforce Development Agency (LWDA) invested $1 million in five organizations focused on providing training and education to day laborers and domestic workers who are engaged in the clean-up and rebuilding of the areas impacted by the wildfires. LWDA coordinated with DIR and Cal/OSHA to collaborate on training and outreach to workers.

    Strengthening worker protections

    Governor Newsom signed legislation expanding collective bargaining rights and increasing protections for app-based drivers, such as those who work for Uber and Lyft. California also extended Cal/OSHA coverage to additional domestic workers, expanding workplace-safety protections statewide.

    As the first state in the nation to adopt enforceable indoor and outdoor heat standards, 2025 marked the first full calendar year under California’s new indoor heat protections. During the 2025 heat season, Cal/OSHA conducted nearly 600 indoor heat inspections statewide and performed 385 targeted high-heat inspection sweeps. Additionally, the division’s criminal referrals tripled, underscoring a strong commitment to worker health and safety.

    The Labor Commissioner’s Office strengthened enforcement across industries, recovering more than $65 million in unpaid wages, penalties and interest; issuing $84 million in citations for 687 labor law violations; and correcting 2,279 violations that affected more than 46,000 workers.

    The Agricultural Labor Relations Board (ALRB) secured multiple unfair labor practice settlements in 2025. This included a settlement with Bonnie Plants, LLC, requiring $114,834.40 in back pay to eight farmworkers and a settlement with Redwood Empire Vineyard Management, Inc., resulting in $33,548 paid to farmworkers after unlawful retaliation.

    Reaching every Californian

    Through California’s Rural Strategic Engagement Program, the state is improving how the government serves workers in rural communities by making resources and services easier to access, clearer to navigate, and more responsive when concerns arise.

    Through coordinated clinics and service in rural areas, the state is ensuring that when workers reach out, they’re connected to the right support. Multiple state departments work together to operate seven one-stop clinics in rural farm areas throughout the Central Valley, Central Coast, Riverside, and Yolo/Colusa regions. At the clinics, farmworkers can report issues such as unsafe conditions or unpaid wages, and the departments coordinate so the farmworker doesn’t have to navigate multiple systems – simplifying government and connecting working people with the services they need.

    Through California’s Rural Strategic Engagement Program, the Labor and Workforce Development Agency and its Departments have begun cross-training staff on skill sets that can enhance their ability to serve agricultural workers, including learning cultural competency skills to engage indigenous farmworkers, presentation and public-speaking skills to better educate workers and employers, and laws and regulations that protect farmworkers even if outside the jurisdiction of the staff.

    Continue Reading

  • SBP launches Pakistan’s Financial Inclusion Index, pegs inclusion at 58.1 for 2024

    The State Bank of Pakistan (SBP) has launched Pakistan’s Financial Inclusion Index (P-FII), a comprehensive measure to assess the state of financial inclusion in the country across access, usage and quality of financial services.

    According to SBP, the overall financial inclusion score stands at 58.1 for 2024. The index shows that access to financial services scored 72.3, usage stood at 62.5, while quality was recorded at 43.9. All indices range from 0 to 100.

    SBP said the P-FII has been developed to support evidence-based policymaking and aligns with its mandate under the SBP Act, 1956 to improve financial inclusion. The index also supports the implementation of the National Financial Inclusion Strategy (NFIS) 2024–28, which aims to expand access to financial services and improve their usage and quality across the country.

    The P-FII is based on 69 indicators covering banking, non-banking and payment services provided by banks and financial institutions. These indicators assess financial sector infrastructure, usage of financial products and services, and the quality of financial services.

    SBP stated that the index has been developed in line with international best practices, with each indicator benchmarked against a defined target representing outcomes the central bank aims to achieve by 2030.

    The central bank added that the development of financial inclusion indices is an emerging trend among central banks globally to assess the inclusivity and outreach of financial systems. Work on the P-FII began in 2023 with a research study reviewing methodologies used by other central banks and multilateral organisations, followed by consultations with domestic and international stakeholders.

    SBP said the P-FII will serve as a key tool to monitor progress on financial inclusion and guide policy interventions going forward.


    Continue Reading

  • Ring in 2026 with these sweet deals across the Alamo City

    Ring in 2026 with these sweet deals across the Alamo City

    Certain places are offering deals for New Year’s Eve & New Year’s Day

    FILE – New Year’s (Canva)

    SAN ANTONIO – The year is almost over, but the party isn’t done quite yet.

    Certain places around the Alamo City are offering deals to celebrate the start of 2026.

    Here’s a list of some of the deals we found:

    • Crumbl – The popular cookie chain is offering six cookies for the price of four for orders placed before 6 p.m. on Wednesday, through the website or app. As a note, Crumbl will be closing early on New Year’s Eve, so be sure to get your dessert fix in before 9 p.m.
    • 7-Eleven – According to a press release, the convenience store chain is offering deals for both New Year’s Eve and New Year’s Day, only through the 7NOW delivery app. Use promo code “CHEERS” for $10 off $20 on New Year’s Eve and promo code “NYDAY” for 50% off on Jan. 1.
    • Baskin-Robbins – Rewards Members can enjoy 31% off Scoops on Wednesday only. Make sure to select the offer in the app or scan the QR code in-store to redeem the promotion.
    • KFC – Now through Jan. 5, the restaurant chain is offering KFC Rewards members a buy-one-get-one-free 8-count dark meat chicken on the bone bucket. This deal can only be redeemed online or through the app at participating locations before checkout.
    • Shake Shack – You can get a free Shakeburger when you purchase $10 on Wednesday. This deal can be redeemed by entering promo code “SHACKCHEER” online, through the app, in a restaurant kiosk or by mentioning it to your cashier at checkout. The code is case sensitive and does not work with other deals.
    • Little Caesars – Fans can get two large, one-topping pizzas for $4.99 when they use the promo code “PIZZAPIZZA.” This deal is available online or through the app at checkout at participating locations, for a limited time only.
    • Krispy Kreme – Now through Jan. 1, participating locations are offering two glazed, or one glazed and one assorted dozen for $20.26. The chain will also offer free deliveries on orders over $5. This deal can be redeemed in stores and online.

    Read more on KSAT:


    Continue Reading

  • Community Resilience, Company Action: Progress in Wildfire Recovery | Edison International

    ROSEMEAD, Calif., Dec. 31, 2025 — As 2025 draws to a close, communities across Southern California continue to show extraordinary resilience following January’s devastating Palisades and Eaton fires. Families, neighbors and community organizations have come together to support one another, demonstrating a spirit that has defined the recovery. Southern California Edison stands with these communities, helping community members rebuild. SCE is also delivering direct compensation to eligible community members affected by the Eaton Fire through its Wildfire Recovery Compensation Program.

    The comprehensive, voluntary direct claims initiative is designed to deliver fair resolutions and fast compensation to eligible individuals and businesses without the uncertainty of lengthy litigation. Since its launch in October, and as of December 31:

    • 1,748 claims submitted
    • 51 offers extended totaling $21.98 million, with no offers declined
    • 27 claims payments made, consisting of 48 individual payments, well in advance of program timelines, reflecting SCE’s commitment to swift, meaningful relief
    • 22% of claims submitted by plaintiffs’ attorneys

    “Witnessing the resilience across our communities is inspiring,” said Pedro J. Pizarro, president and CEO of Edison International, SCE’s parent company. “Through the Wildfire Recovery Compensation Program, community members don’t have to wait for the final conclusions in the Eaton Fire investigation to get the financial support they need to begin rebuilding.”

    Compensation Program: Community Voices at the Core

    Before launching the program in the fall, SCE held more than a dozen listening sessions with community members, public officials and legal representatives to seek feedback on the draft program details. Over 1,000 participants shared their feedback and offered ideas.

    As a result, more than 50 updates were made, from expanding eligibility to simplifying documentation requirements. Dialogue has continued after the program’s launch to educate and connect with eligible community members, with SCE-hosted community meetings and workshops, town halls and engagements with community organizations.

    Compensation Program: Fair and Fast

    SCE worked with Kenneth R. Feinberg and Camille S. Biros — renowned experts in compensation fund design and administration — on program design. Their experience and compassion helped shape a process that prioritizes speed and equity.

    When the program launched on Oct. 29, SCE committed to processing claims quickly and delivering payments fast.

    • Claimants receive a settlement offer within 90 days of a substantially complete claim. To date, SCE has provided dozens of offers well in advance of the 90 days.
    • Payments are made within 30 days after all conditions have been satisfied in the settlement agreement, including SCE’s receipt of it — signed and notarized.
    • If a claim requires analysis beyond the Fast Pay option, a Detailed Review is available.

    “In recent weeks, we’ve seen real progress as more people access the support available to them,” Pizarro noted.

    Participation in the program is entirely voluntary, and claimants are not obligated to accept any settlement offered. On average, completing the claim form takes just over 90 minutes, and assistance is available by calling 888-912-8528.

    The program includes owner and tenant claims for total and partial structure loss, commercial property loss, business interruption, non-burn damage (such as smoke, soot or ash), physical injury and loss of life. A direct claim premium is offered to incentivize participation in the program, and a 10% adder is available to cover attorneys’ fees (excluding the direct claim premium).

    From now through Nov. 30, 2026, claims can be submitted through a secure, dedicated website. Access detailed guidance, sample offers, and frequently asked questions in English and Spanish, and submit a claim, via the Wildfire Recovery Compensation Program web page.

    Rebuilding Together

    As part of SCE’s commitment to long-term recovery, the company is investing in infrastructure improvements that will help protect against future wildfires and support growth in Southern California. This includes plans to underground about 153 distribution circuit miles in and around Altadena and Malibu and upgrade critical infrastructure to meet increasing customer demand. In 2025, 40 miles were undergrounded throughout SCE’s service area, with 19.3 completed in the Malibu area and three in the Altadena community.

    SCE also continues to deploy advanced grid technologies — such as automation — to enhance equipment maintenance, isolate disruptions and restore service faster.

    Update on Eaton Fire Investigation

    Following the unprecedented circumstances that preceded the tragic Eaton Fire, SCE began its investigation in January with aerial and on-site inspections. The company continues to conduct close-up equipment testing in coordination with local authorities and stakeholders.

    Based on currently available information about the ignition of the Eaton Fire, it is likely that SCE equipment could have been associated with the ignition, and induction of the idle line remains a viable explanation. To date, SCE is not aware of evidence pointing to another plausible source of ignition. While the investigation is ongoing, the company is focusing on compensation and recovery now — taking action to support people and help communities move forward.

    “Our commitment is to continue connecting people with the resources they need so they can rebuild and thrive,” said Pizarro.

    About Southern California Edison

    An Edison International (NYSE: EIX) company, Southern California Edison is one of the nation’s largest electric utilities, serving a population of approximately 15 million via 5 million customer accounts in a 50,000-square-mile service area within Central, Coastal and Southern California.

    Continue Reading

  • IBC Bank plans JW Marriott hotel conversion for downtown office building

    IBC Bank plans JW Marriott hotel conversion for downtown office building

    SAN ANTONIO – The flag for a future downtown hotel has been picked.

    Laredo-based IBC Bank plans to convert its downtown office tower at 175 E. Houston St. into a JW Marriott and add an entirely new structure to the complex, according to design documents submitted to the City of San Antonio. Renderings show the bank aims to build a third structure next to IBC Centre I at the corner of East Travis and North St. Mary’s Streets for parking, a rooftop pool and other amenities.

    IBC Centre I would house 300 hotel rooms for the flag, which falls under Marriott International‘s luxury lineup. IBC Centre II, the bank’s San Antonio base of operations, would remain an office.

    HKS Architects & Designers and SWA Group are attached to the design team. Dimension Hospitality, which manages the Embassy Suites by Hilton San Antonio Riverwalk Downtown, is also on board.

    The bank wants to begin development in spring 2026. (HKS, INC/SABJ)

    In a statement to city staff, project leaders said the proposed hotel would be a “cultural and architectural anchor” for the urban core.

    “Framed by the historic 1926 Texas Theater façade and the adaptive reuse of O’Neil Ford’s 1983 office building, the hotel weaves past and future together,” the team wrote. “It offers a vibrant hospitality experience that honors San Antonio’s architectural heritage, urban character and the dynamic energy of the River Walk, creating a destination that is both historically grounded and forward-looking.”

    In previous reviews with the city, IBC Bank has indicated it wants to start construction in spring 2026. After Visionworks announced it would vacate its massive lease in the 280,000-square-foot building in 2024, IBC Bank Executive Vice President Bernardo De La Garza said pivoting away from office use would be more prudent than trying to lease up the space again.

    “There’s not a lot of office tenants moving downtown,” he said. “I think that our competition there is against some of the newer buildings that have more amenities, that are better positioned in terms of the amenity package.”

    The proposal has been referred to the Historic and Design Review Commission, though it was unclear at press time when the panel would take up the measure. A representative for IBC Bank did not respond to a request for comment by publication time.

    Read more of this story at the San Antonio Business Journal website.

    Editor’s note: This story was published through a partnership between KSAT and the San Antonio Business Journal.

    Read also from SABJ:

    Copyright 2025 by KSAT – All rights reserved.

    Continue Reading

  • Shi, J. et al. Active biointegrated living electronics for managing inflammation. Science 384, 1023–1030 (2024).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Chen, C., Ding, S. & Wang, J. Digital health for aging populations. Nat. Med. 29, 1623–1630 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wang, C. et al. Bioadhesive ultrasound for long-term continuous imaging of diverse organs. Science 377, 517–523 (2022).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Gao, W. et al. Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis. Nature 529, 509–514 (2016).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Musk, E. An integrated brain-machine interface platform with thousands of channels. J. Med. Internet Res. 21, e16194 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chortos, A., Liu, J. & Bao, Z. Pursuing prosthetic electronic skin. Nat. Mater. 15, 937–950 (2016).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Williams, E. Environmental effects of information and communications technologies. Nature 479, 354–358 (2011).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Shi, H. H. et al. Sustainable electronic textiles towards scalable commercialization. Nat. Mater. 22, 1294–1303 (2023).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Chen, S. How much energy will AI really consume? The good, the bad and the unknown. Nature 639, 22–24 (2025).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Kim, H. J., Koo, J. H., Lee, S., Hyeon, T. & Kim, D.-H. Materials design and integration strategies for soft bioelectronics in digital healthcare. Nat. Rev. Mater. 10, 654–673 (2025).

    Article 
    ADS 

    Google Scholar 

  • Nikolka, M., Göke, S., Burkacky, O., Spiller, P. & Patel, M. Unlocking net-zero in semiconductor manufacturing. Nat. Rev. Electr. Eng. 1, 487–488 (2024).

    Article 

    Google Scholar 

  • McCulloch, I., Chabinyc, M., Brabec, C., Nielsen, C. B. & Watkins, S. E. Sustainability considerations for organic electronic products. Nat. Mater. 22, 1304–1310 (2023).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • The Global E-Waste Monitor 2024–Electronic Waste Rising Five Times Faster than Documented e-Waste Recycling (United Nations, 2024); https://ewastemonitor.info/wp-content/uploads/2024/12/GEM_2024_EN_11_NOV-web.pdf.

  • Yang, Q. et al. Ecoresorbable and bioresorbable microelectromechanical systems. Nat. Electron. 5, 526–538 (2022).

    Article 
    CAS 

    Google Scholar 

  • Jeong, H. et al. Novel eco-friendly starch paper for use in flexible, transparent and disposable organic electronics. Adv. Funct. Mater. 28, 1704433–1704442 (2018).

    Article 

    Google Scholar 

  • Zhang, Z. et al. Recyclable vitrimer-based printed circuit boards for sustainable electronics. Nat. Sustain. 7, 616–627 (2024).

    Article 

    Google Scholar 

  • Vũ, N. Đ et al. Gallium-catalyzed recycling of silicone waste with boron trichloride to yield key chlorosilanes. Science 388, 392–400 (2025).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Park, H. et al. Organic flexible electronics with closed-loop recycling for sustainable wearable technology. Nat. Electron. 7, 39–50 (2024).

    Article 
    CAS 

    Google Scholar 

  • Corzo, D. et al. High-performing organic electronics using terpene green solvents from renewable feedstocks. Nat. Energy 8, 62–73 (2023).

    Article 
    ADS 

    Google Scholar 

  • Min, J. et al. An autonomous wearable biosensor powered by a perovskite solar cell. Nat. Electron. 6, 630–641 (2023).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Cordella, M., Alfieri, F. & Sanfelix, J. Reducing the carbon footprint of ICT products through material efficiency strategies: a life cycle analysis of smartphones. J. Ind. Ecol. 25, 448–464 (2021).

    Article 

    Google Scholar 

  • Peng, P. & Shehabi, A. Regional economic potential for recycling consumer waste electronics in the United States. Nat. Sustain. 6, 93–102 (2023).

    Article 

    Google Scholar 

  • Moni, S. M., Mahmud, R., High, K. & Carbajales-Dale, M. Life cycle assessment of emerging technologies: a review. J. Ind. Ecol. 24, 52–63 (2020).

    Article 
    CAS 

    Google Scholar 

  • Strazza, C. et al. Technology Readiness Level—Guidance Principles for Renewable Energy Technologies Final Report (European Commission, Directorate-General for Research and Innovation, 2017).

  • Huijbregts, M. A. J. et al. ReCiPe2016: a harmonised life cycle impact assessment method at midpoint and endpoint level. Int. J. Life Cycle Assess. 22, 138–147 (2017).

    Article 

    Google Scholar 

  • Dexcom G6 CGM system for personal use. Dexcom https://provider.dexcom.com/products/g6-personal-cgm (2025).

  • Williams, E. D., Ayres, R. U. & Heller, M. The 1.7 kilogram microchip: energy and material use in the production of semiconductor devices. Environ. Sci. Technol. 36, 5504–5510 (2002).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Yang, Y. et al. A laser-engraved wearable sensor for sensitive detection of uric acid and tyrosine in sweat. Nat. Biotechnol. 38, 217–224 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Xu, Y. et al. Pencil–paper on-skin electronics. Proc. Natl Acad. Sci. USA 117, 18292–18301 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bonnassieux, Y. et al. The 2021 flexible and printed electronics roadmap. Flex. Print. Electron. 6, 023001 (2021).

    Article 
    CAS 

    Google Scholar 

  • Schaubroeck, T. et al. Attributional & consequential life cycle assessment: definitions, conceptual characteristics and modelling restriction. Sustainability 13, 7386–7433 (2021).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Norgate, T. & Haque, N. Using life cycle assessment to evaluate some environmental impacts of gold production. J. Clean. Prod. 29–30, 53–63 (2012).

    Article 

    Google Scholar 

  • Bigum, M., Damgaard, A., Scheutz, C. & Christensen, T. H. Environmental impacts and resource losses of incinerating misplaced household special wastes (WEEE, batteries, ink cartridges and cables). Resour. Conserv. Recycl. 122, 251–260 (2017).

    Article 

    Google Scholar 

  • Global smartphone market soared 7% in 2024 as vendors prepare for tricky 2025. canalys.com https://canalys.com/newsroom/worldwide-smartphone-market-2024 (2025).

  • Yuk, H., Lu, B. & Zhao, X. Hydrogel bioelectronics. Chem. Soc. Rev. 48, 1642–1667 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Feig, V. R., Tran, H. & Bao, Z. Biodegradable polymeric materials in degradable electronic devices. ACS Cent. Sci. 4, 337–348 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fujisaki, Y. et al. Transparent nanopaper-based flexible organic thin-film transistor array. Adv. Funct. Mater. 24, 1657–1663 (2014).

    Article 
    CAS 

    Google Scholar 

  • Material property data. MatWeb https://www.matweb.com/index.aspx (2025).

  • Fan, Z.-J. et al. Facile synthesis of graphene nanosheets via Fe reduction of exfoliated graphite oxide. ACS Nano 5, 191–198 (2011).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Worfolk, B. J. et al. Ultrahigh electrical conductivity in solution-sheared polymeric transparent films. Proc. Natl Acad. Sci. USA 112, 14138–14143 (2015).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Someya, T., Bao, Z. & Malliaras, G. G. The rise of plastic bioelectronics. Nature 540, 379–385 (2016).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Liu, H., Liu, D., Yang, J., Gao, H. & Wu, Y. Flexible electronics based on organic semiconductors: from patterned assembly to integrated applications. Small 19, 2206938 (2023).

    Article 
    CAS 

    Google Scholar 

  • Chu, M. et al. Co-recycling of plastics and other waste materials. Nat. Rev. Clean Technol. 1, 320–332 (2025).

    Article 

    Google Scholar 

  • Dai, Y. et al. Soft hydrogel semiconductors with augmented biointeractive functions. Science 386, 431–439 (2024).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Piao, Z., Agyei Boakye, A. A. & Yao, Y. Environmental impacts of biodegradable microplastics. Nat. Chem. Eng. 1, 661–669 (2024).

    Article 

    Google Scholar 

  • Peng, J. et al. Surface coordination layer passivates oxidation of copper. Nature 586, 390–394 (2020).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Bell, E. L. et al. Directed evolution of an efficient and thermostable PET depolymerase. Nat. Catal. 5, 673–681 (2022).

    Article 
    CAS 

    Google Scholar 

  • Jiang, Y. et al. A universal interface for plug-and-play assembly of stretchable devices. Nature 614, 456–462 (2023).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Sacchi, R. et al. Prospective environmental impact assement (premise): a streamlined approach to producing databases for prospective life cycle assessment using integrated assessment models. Renew. Sustain. Energy Rev. 160, 112311 (2022).

    Article 

    Google Scholar 

  • Yoshimoto, M. & Izumi, S. Recent progress of biomedical processor SoC for wearable healthcare application: a review. IEICE Trans. Electron. 102, 245–259 (2019).

    Article 
    ADS 

    Google Scholar 

  • Malmodin, J. & Lundén, D. The energy and carbon footprint of the global ICT and E&M sectors. Sustainability 10, 3027–3057 (2018).

  • Ercan M., Malmodin J., Bergmark P., Kimfalk E., & Nilsson E. Life cycle assessment of a smartphone. In Proc. ICT for Sustainability 2016 124–133 (Atlantis Press, 2016).

  • Suckling, J. & Lee, J. Redefining scope: the true environmental impact of smartphones? Int. J. Life Cycle Assess. 20, 1181–1196 (2015).

    Article 
    CAS 

    Google Scholar 

  • Zhang, T. et al. Life cycle assessment (LCA) of circular consumer electronics based on IC recycling and emerging PCB assembly materials. Sci. Rep. 14, 29183 (2024).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhang, M. et al. Towards sustainable perovskite light-emitting diodes. Nat. Sustain. 8, 315–324 (2025).

    Article 

    Google Scholar 

  • Yang, C. et al. A bioinspired permeable junction approach for sustainable device microfabrication. Nat. Sustain. 7, 1190–1203 (2024).

    Article 

    Google Scholar 

  • Li, P. et al. Monolithic silicon for high spatiotemporal translational photostimulation. Nature 626, 990–998 (2024).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Malmodin J. & Lövehagen N. A methodology for simplified LCAs of electronic products. In 2024 Electronics Goes Green 2024+ (EGG) 1–12 (IEEE, 2024).

  • Zhang, Z. et al. DeltaLCA: comparative life-cycle assessment for electronics design. In Proc. ACM on Interactive, Mobile, Wearable and Ubiquitous Technologies, Vol. 8, 1–29 (ACM, 2024).

  • Teer J. & Bertolini M. Reaching Breaking Point: The Semiconductor and Critical Raw Material Ecosystem at a Time of Great Power Rivalry (The Hague Centre for Strategic Studies, 2022); https://hcss.nl/wp-content/uploads/2022/10/Reaching-breaking-point-full-HCSS-2022-revised.pdf.

  • Pizzol, M. et al. Normalisation and weighting in life cycle assessment: quo vadis?. Int. J. Life Cycle Assess. 22, 853–866 (2017).

    Article 

    Google Scholar 

  • Wang, B., Tian, X., Stranks, S. D. & You, F. Transitioning photovoltaics to all-perovskite tandems reduces 2050 climate change impacts of PV sector by 16%. Environ. Sci. Technol. 59, 9540–9551 (2025).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Bass, F. M. A new product growth for model consumer durables. Manag. Sci. 50, 1825–1832 (2004).

    Article 

    Google Scholar 

  • Kaminski, J. Diffusion of innovation theory: theory in nursing informatics column. Can. J. Nurs. Inform. 6, 1–6 (2011).

  • Norton, J. A. & Bass, F. M. A diffusion theory model of adoption and substitution for successive generations of high-technology products. Manag. Sci. 33, 1069–1086 (1987).

    Article 

    Google Scholar 

  • Sultan, F., Farley, J. U. & Lehmann, D. R. A meta-analysis of applications of diffusion models. J. Mark. Res. 27, 70–77 (1990).

    Article 

    Google Scholar 

  • Managing Complications in Pregnancy and Childbirth: A Guide for Midwives and Doctors (World Health Organization, 2003).

  • Zhou, B. et al. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. Lancet 398, 957–980 (2021).

    Article 

    Google Scholar 

  • Cardiovascular diseases (CVDs). WHO https://www.who.int/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (2021).

  • Papolos, A., Narula, J., Bavishi, C., Chaudhry, F. A. & Sengupta, P. P. U.S. hospital use of echocardiography: insights from the nationwide inpatient sample. J. Am. Coll. Cardiol. 67, 502–511 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Pawar P. Apple Watch statistics by revenue, sales, series, market share, country, users and usage. Coolest Gadgets https://www.coolest-gadgets.com/apple-watches-statistics/ (2023).

  • Forti, V., Baldé, K. & Kuehr, R. E-waste Statistics: Guidelines on Classifications, Reporting and Indicators (United Nations Univ., 2018).

  • Electrical and Electronic Equipment Placed on Market Calculation Tool Manual (UNITAR, 2023); https://academy-ce.info/wp-content/uploads/2024/02/ENG-EEE-POM-calculation-tool-manual.pdf.

  • Miller, T. R., Duan, H., Gregory, J., Kahhat, R. & Kirchain, R. Quantifying domestic used electronics flows using a combination of material flow methodologies: a US case study. Environ. Sci. Technol. 50, 5711–5719 (2016).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Weibull formulas. What are the basic lifetime distribution models used for non-repairable populations? NIST https://www.itl.nist.gov/div898/handbook/apr/section1/apr162.htm?utm (2025).

  • Ciroth, A., Muller, S., Weidema, B. & Lesage, P. Empirically based uncertainty factors for the pedigree matrix in ecoinvent. Int. J. Life Cycle Assess. 21, 1338–1348 (2016).

    Article 

    Google Scholar 

  • Uncertainties. Ecoinvent Support https://support.ecoinvent.org/uncertainties (2025).

  • Gong, J., Darling, S. B. & You, F. Perovskite photovoltaics: life-cycle assessment of energy and environmental impacts. Energy Environ. Sci. 8, 1953–1968 (2015).

    Article 
    CAS 

    Google Scholar 

  • Worrell, E. et al. Potentials and Policy Implications of Energy and Material Efficiency Improvement (United Nations, 1997).

  • Zio XT® long-term continuous monitoring service. iRhythm Technologies https://www.irhythmtech.com/us/en/solutions-services/irhythm-service/zio-xt (2025).

  • Aktiia 24/7. Blood pressure monitor. Aktiia https://aktiia.com/uk/blood-pressure-monitor (2024).

Continue Reading

  • Breslow, R. Artificial enzymes. Science 218, 532–537 (1982).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • DeGrado, W. F., Wasserman, Z. R. & Lear, J. D. Protein design, a minimalist approach. Science 243, 622–628 (1989).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Kuhlman, B. et al. Design of a novel globular protein fold with atomic-level accuracy. Science 302, 1364–1368 (2003).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Castriciano, M. A., Romeo, A., Baratto, M. C., Pogni, R. & Scolaro, L. M. Supramolecular mimetic peroxidase based on hemin and PAMAM dendrimers. Chem. Commun. 14, 688–690 (2008).

    Article 

    Google Scholar 

  • Schmidt, B. V. K. J., Fechler, N., Falkenhagen, J. & Lutz, J.-F. Controlled folding of synthetic polymer chains through the formation of positionable covalent bridges. Nat. Chem. 3, 234–238 (2011).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Terashima, T. et al. Single-chain folding of polymers for catalytic systems in water. J. Am. Chem. Soc. 133, 4742–4745 (2011).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Wiester, M. J., Ulmann, P. A. & Mirkin, C. A. Enzyme mimics based upon supramolecular coordination chemistry. Angew. Chem. Int. Ed. 50, 114–137 (2011).

    Article 
    CAS 

    Google Scholar 

  • Kaphan, D. M., Levin, M. D., Bergman, R. G., Raymond, K. N. & Toste, F. D. A supramolecular microenvironment strategy for transition metal catalysis. Science 350, 1235–1238 (2015).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Nath, I., Chakraborty, J. & Verpoort, F. Metal organic frameworks mimicking natural enzymes: a structural and functional analogy. Chem. Soc. Rev. 45, 4127–4170 (2016).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Liu, Q., Wang, H., Shi, X. H., Wang, Z.-G. & Ding, B. Q. Self-assembled DNA/peptide-based nanoparticle exhibiting synergistic enzymatic activity. ACS Nano 11, 7251–7258 (2017).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Mundsinger, K., Izuagbe, A., Tuten, B. T., Roesky, P. W. & Barner-Kowollik, C. Single chain nanoparticles in catalysis. Angew. Chem. Int. Ed. 63, e202311734 (2024).

    Article 
    CAS 

    Google Scholar 

  • Lutz, J.-F., Ouchi, M., Liu, D. R. & Sawamoto, M. Sequence-controlled polymers. Science 341, 1238149 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Lombardi, A., Pirro, F., Maglio, O., Chino, M. & DeGrado, W. F. De novo design of four-helix bundle metalloproteins: one scaffold, diverse reactivities. Acc. Chem. Res. 52, 1148–1159 (2019).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Rose, G. D., Fleming, P. J., Banavar, J. R. & Maritan, A. A backbone-based theory of protein folding. Proc. Natl Acad. Sci. USA 103, 16623–16633 (2006).

    Article 
    ADS 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Zaccai, G. How soft is a protein? A protein dynamics force constant measured by neutron scattering. Science 288, 1604–1607 (2000).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Henzler-Wildman, K. & Kern, D. Dynamic personalities of proteins. Nature 450, 964–972 (2007).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Magazù, S. et al. Protein dynamics as seen by (quasi) elastic neutron scattering. Biochim. Biophys. Acta Gen. Subj. 1861, 3504–3512 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Robertson, D. E. et al. Design and synthesis of multi-haem proteins. Nature 368, 425–432 (1994).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Sugase, K., Dyson, H. J. & Wright, P. E. Mechanism of coupled folding and binding of an intrinsically disordered protein. Nature 447, 1021–1025 (2007).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Hilburg, S. L., Ruan, Z., Xu, T. & Alexander-Katz, A. Behavior of protein-inspired synthetic random heteropolymers. Macromolecules 53, 9187–9199 (2020).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Jiang, T. et al. Single-chain heteropolymers transport protons selectively and rapidly. Nature 577, 216–220 (2020).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Daghrir, R. & Drogui, P. Tetracycline antibiotics in the environment: a review. Environ. Chem. Lett. 11, 209–227 (2013).

    Article 
    CAS 

    Google Scholar 

  • Dill, K. A. et al. Principles of protein folding — a perspective from simple exact models. Protein Sci. 4, 561–602 (1995).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Ruan, Z. et al. Population-based heteropolymer design to mimic protein mixtures. Nature 615, 251–258 (2023).

    Article 
    ADS 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Artar, M., Souren, E. R. J., Terashima, T., Meijer, E. W. & Palmans, A. R. A. Single chain polymeric nanoparticles as selective hydrophobic reaction spaces in water. ACS Macro Lett. 4, 1099–1103 (2015).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Hoshino, Y. et al. The rational design of a synthetic polymer nanoparticle that neutralizes a toxic peptide in vivo. Proc. Natl Acad. Sci. USA 109, 33–38 (2012).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Popot, J.-L. et al. Amphipols from A to Z. Annu. Rev. Biophys. 40, 379–408 (2011).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Chakraborty, A. K. & Shakhnovich, E. I. Phase behavior of random copolymers in quenched random media. J. Chem. Phys. 103, 10751–10763 (1995).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Geissler, P. L. & Shakhnovich, E. I. Mechanical response of random heteropolymers. Macromolecules 35, 4429–4436 (2002).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Panganiban, B. et al. Random heteropolymers preserve protein function in foreign environments. Science 359, 1239–1243 (2018).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Koshland, D. E. Jr The key–lock theory and the induced fit theory. Angew. Chem. Int. Ed. Engl. 33, 2375–2378 (1995).

    Article 

    Google Scholar 

  • Jayapurna, I. et al. Sequence design of random heteropolymers as protein mimics. Biomacromolecules 24, 652–660 (2023).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Hoshino, T. & Sato, T. Squalene–hopene cyclase: catalytic mechanism and substrate recognition. Chem. Commun. 4, 291–301 (2002).

    Article 

    Google Scholar 

  • Moffet, D. A. et al. Peroxidase activity in heme proteins derived from a designed combinatorial library. J. Am. Chem. Soc. 122, 7612–7613 (2000).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Walker, F. A. Models of the bis-histidine-ligated electron-transferring cytochromes. Comparative geometric and electronic structure of low-spin ferro- and ferrihemes. Chem. Rev. 104, 589–616 (2004).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Tronnet, A. et al. Star-like polypeptides as simplified analogues of horseradish peroxidase (HRP) metalloenzymes. Macromol. Biosci. 24, 2400155–2400155 (2024).

    Article 
    CAS 

    Google Scholar 

  • Yu, H. et al. Mapping composition evolution through synthesis, purification, and depolymerization of random heteropolymers. J. Am. Chem. Soc. 146, 6178–6188 (2024).

    Article 
    ADS 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Arbe, A., Colmenero, J., Monkenbusch, M. & Richter, D. Dynamics of glass-forming polymers: “homogeneous” versus “heterogeneous” scenario. Phys. Rev. Lett. 81, 590–593 (1998).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Hart-Cooper, W. M., Clary, K. N., Toste, F. D., Bergman, R. G. & Raymond, K. N. Selective monoterpene-like cyclization reactions achieved by water exclusion from reactive intermediates in a supramolecular catalyst. J. Am. Chem. Soc. 134, 17873–17876 (2012).

    Article 
    ADS 
    PubMed 
    CAS 

    Google Scholar 

  • Hammer, S. C., Marjanovic, A., Dominicus, J. M., Nestl, B. M. & Hauer, B. Squalene hopene cyclases are protonases for stereoselective Brønsted acid catalysis. Nat. Chem. Biol. 11, 121–126 (2015).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Gibney, B. R. & Dutton, P. L. Histidine placement in de novo–designed heme proteins. Protein Sci. 8, 1888–1898 (1999).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Walker, F. A., Reis, D. & Balke, V. L. Models of the cytochromes b. 5. EPR studies of low-spin iron(III) tetraphenylporphyrins. J. Am. Chem. Soc. 106, 6888–6898 (1984).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Murphy, E. A. et al. High-throughput generation of block copolymer libraries via click chemistry and automated chromatography. Macromolecules 58, 8369–8376 (2025).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Cochran, A. G. & Schultz, P. G. Peroxidase-activity of an antibody heme complex. J. Am. Chem. Soc. 112, 9414–9415 (1990).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Tracy, T. S. Atypical cytochrome P450 kinetics. Drugs R D 7, 349–363 (2006).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Wu, G.-R. et al. Efficient degradation of tetracycline antibiotics by engineered myoglobin with high peroxidase activity. Molecules 27, 8660 (2022).

    Article 
    PubMed 
    PubMed Central 
    CAS 

    Google Scholar 

  • Jaacks, V. A novel method of determination of reactivity ratios in binary and ternary copolymerizations. Makromolek. Chem. 161, 161–172 (1972).

    Article 
    CAS 

    Google Scholar 

  • Flynn, P. F., Mattiello, D. L., Hill, H. D. W. & Wand, A. J. Optimal use of cryogenic probe technology in NMR studies of proteins. J. Am. Chem. Soc. 122, 4823–4824 (2000).

    Article 
    ADS 
    CAS 

    Google Scholar 

  • Andreini, C., Cavallaro, G., Lorenzini, S. & Rosato, A. MetalPDB: a database of metal sites in biological macromolecular structures. Nucleic Acids Res. 41, D312–D319 (2013).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Ravel, B. & Newville, M. ATHENA, ARTEMIS, HEPHAESTUS: data analysis for X-ray absorption spectroscopy using IFEFFIT. J. Synchrotron Radiat. 12, 537–541 (2005).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Martínez, L., Andrade, R., Birgin, E. G. & Martínez, J. M. PACKMOL: a package for building initial configurations for molecular dynamics simulations. J. Comput. Chem. 30, 2157–2164 (2009).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Shu, J. Y. et al. Amphiphilic peptide−polymer conjugates based on the coiled-coil helix bundle. Biomacromolecules 11, 1443–1452 (2010).

    Article 
    PubMed 
    CAS 

    Google Scholar 

  • Continue Reading