Category: 3. Business

The agency added a boxed warning to the therapy after two non-ambulatory pediatric patients died from acute liver failure following treatment. The new label removes approval for use in non-ambulatory patients entirely, limiting the drug to ambulatory patients aged four and older.

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Earlier this year, Sarepta voluntarily paused distribution of Elevidys for non-ambulatory patients in June after the FDA issued a safety communication following the deaths.

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Metsera (MTSR) gained the spotlight this week as a result of a sharp turnaround in its stock price over the past month. Investors are taking a closer look after shares climbed more than 34% since early May.

See our latest analysis for Metsera.

After a sluggish start to the year, Metsera’s momentum has surged, as shown by its exceptional 166% year-to-date share price return. This sharp turn is drawing renewed interest from investors who are looking for signs of sustainable growth potential or shifting risk profiles.

If rapid gains like these have you scanning for more standout moves, it could be the perfect moment to broaden your search and discover fast growing stocks with high insider ownership

With Metsera’s rapid climb, investors are left wondering if the current price accurately reflects the company’s future prospects or if there is an overlooked opportunity for further gains waiting to be seized.

Metsera’s stock is currently trading at a price-to-book ratio of 22x, which stands out as markedly higher than the average for its industry and peer group. This suggests the market is pricing in a lot of optimism relative to comparable companies.

The price-to-book ratio measures how much investors are willing to pay for each dollar of net assets on the balance sheet. For biotech firms, this metric can be revealing when comparing valuations across companies with uncertain profits or long development timelines.

At 22x, Metsera’s valuation is sharply elevated compared to both the US Biotechs industry average of 2.6x and a peer group average of 6.3x. Such a premium could reflect investor excitement about the company’s future prospects or simply represent overexuberance. With no meaningful revenues and persistent unprofitability, it is difficult to pinpoint what justifies such a steep multiple right now.

See what the numbers say about this price — find out in our valuation breakdown.

Result: Price-to-Book of 22x (OVERVALUED)

However, weak revenue growth and a discounted analyst price target could signal challenges ahead. This may temper some of the recent investor enthusiasm for Metsera.

Find out about the key risks to this Metsera narrative.

If you think the current take misses the mark or you enjoy digging into the numbers firsthand, you can craft your own perspective in just minutes. Do it your way

A great starting point for your Metsera research is our analysis highlighting 4 important warning signs that could impact your investment decision.

Unlock your edge by targeting stocks with overlooked growth, future tech ambitions, or robust cash flows. Bold moves today could put you far ahead of the crowd.

The new live insight platform, built with IBM watsonx, will deliver real-time milestones, streaks and records directly to UFC broadcasts and data systems

Nov 14, 2025

ARMONK, N.Y. and LAS VEGAS, Nov. 14, 2025 /PRNewswire/ — IBM (NYSE: IBM) and UFC, the world’s premier mixed martial arts organization, today announced the next phase of their technological evolution with the launch of In-Fight Insights, an AI-driven live alert platform that monitors and reports in real time when notable milestones, streaks and records occur during UFC events. It is slated to debut at UFC® 322: DELLA MADDALENA vs. MAKHACHEV, which takes place at New York’s Madison Square Garden this Saturday, November 15.

As the Official AI Partner of UFC, the new technology solution taps into more than 13.2 million UFC data points from 20+ years of fights and more than 2400 current and former UFC athletes – elevating the viewing experience for both hardcore and casual fans alike.

Part of the UFC Insights Engine built with IBM watsonx, the new In-Fight Insights capability marks the most advanced evolution of that system to date and the first live in-fight integration since the IBM-UFC partnership launched one year ago. Moving beyond pre- and post-fight applications into real-time moments, the engine is built to identify and trigger key fight moments, such as record-setting strike totals, streaks and other significant milestones as they happen.

“UFC Insights Engine built with IBM watsonx is a complex AI package that goes deep to unearth new, real-time insights for fans in seconds,” said Alon Cohen, Executive Vice President of Innovation for TKO. “Anyone who uses AI tools knows they are normally able to go deep or fast, but not both. In collaborating with IBM for these new in-fight stats though, we have optimized Insights Engine to accomplish both, a true game-changer.”  

While Pre-Fight Insights will continue to provide analysis moments before the opening bell, In-Fight Insights will give broadcasters immediate contextual understanding to share with fans. By integrating these insights into the broadcast feed, UFC and IBM are delivering a new level of in-the-moment intelligence with commentators, production teams and fans. Data will also be stored in the UFC Insights Engine for archival and analytical purposes.

“The launch of In-Fight Insights is the latest example of how AI is really changing the game for the live sports viewing experience for fans around the world,” said Jonathan Adashek, Senior Vice President, Marketing & Communications, IBM. “It’s a testament to the commitment of UFC to always think outside the octagon, to best capture the enormous storytelling potential and human element of the action going on inside the cage.”

Since announcing their partnership in November 2024, UFC and IBM have worked together to establish the foundation of the UFC Insights Engine, aggregating and analyzing the organization’s rich library of fight data to create more personalized and data-driven fan experiences. The In-Fight Insights addition is part of a broader effort to scale the Insights Engine across all UFC platforms, including live broadcasts, pre-event programming, social media channels and in-venue activations.

As the popularity of mixed martial arts continues to expand globally, UFC and IBM are leveraging AI and data to bring fans closer to the sport and its athletes than ever before.

About UFC

UFC® is the world’s premier mixed martial arts organization (MMA), with more than 700 million fans and approximately 318 million social media followers. The organization produces more than 40 live events annually in some of the most prestigious arenas around the world while distributing programming to more than 950 million broadcast and digital households across more than 210 countries and territories. UFC’s athlete roster features the world’s best MMA athletes representing more than 75 countries. The organization’s digital offerings include UFC FIGHT PASS®, one of the world’s leading streaming services for combat sports. UFC is part of TKO Group Holdings (NYSE: TKO) and is headquartered in Las Vegas, Nevada. For more information, visit UFC.com and follow UFC at Facebook.com/UFC and @UFC on X, Snapchat, Instagram, and TikTok: @UFC. 

About IBM

IBM is a leading provider of global hybrid cloud and AI, and consulting expertise. We help clients in more than 175 countries capitalize on insights from their data, streamline business processes, reduce costs and gain the competitive edge in their industries. Thousands of governments and corporate entities in critical infrastructure areas such as financial services, telecommunications and healthcare rely on IBM’s hybrid cloud platform and Red Hat OpenShift to affect their digital transformations quickly, efficiently and securely. IBM’s breakthrough innovations in AI, quantum computing, industry-specific cloud solutions and consulting deliver open and flexible options to our clients. All of this is backed by IBM’s long-standing commitment to trust, transparency, responsibility, inclusivity and service. Visit www.ibm.com for more information.

Media Contacts:

IBM, ibm@berkcommunications.com

UFC, ufcpress@ufc.com

SOURCE IBM

Washington, DC: An International Monetary Fund (IMF) team led by Ms. Maria Gonzalez conducted discussions on the Indonesian economy for the 2025 Article IV Consultation over November 3-12, 2025. At the end of the mission, Ms. Gonzalez issued the following statement:

“The Indonesian economy has shown resilience amid adverse shocks. Growth is expected to remain steady at 5.0 percent in 2025 and 5.1 percent in 2026, despite a challenging external environment, reflecting support from fiscal and monetary policies. Headline inflation is well anchored and projected to converge towards the midpoint of the target range. The current account deficit would remain well contained in 2025-26, with comfortable reserves.

“Risks are tilted to the downside. Escalating trade tensions, prolonged uncertainty, and global financial market volatility remain key external risks. On the domestic side, large policy shifts, if not implemented with sufficiently robust guardrails, could build up vulnerabilities. Upside risks include bolder structural reforms, including faster-than-anticipated push on the trade front, and positive spillovers from stronger growth among trading partners.

“Staff expect the fiscal deficit to widen to around 2.8 percent of GDP in 2025, and around 2.9 percent next year based on more conservative growth and revenue projections than those envisaged in the 2026 budget of 2.7 percent of GDP. Carefully managing budget execution to secure the authorities’ budget target would provide needed fiscal support to the economy while preserving fiscal space to be deployed if downside risks materialize. Keeping fiscal risks well-contained will require continued careful fiscal management as well as strong safeguards and rigorous oversight of quasi-fiscal operations. Stronger revenue mobilization, with a focus on high-quality spending and spending efficiency would further enhance fiscal policy effectiveness to support growth.

“The shift to monetary policy easing, with the realignment of BI’s various instruments in a supportive direction, is appropriate. The 150 bps rate cuts and liquidity-enhancing measures should gradually strengthen credit growth; credit demand would be boosted by efforts to support confidence and policy predictability. Going forward, there may be room for some further policy rate cuts. The extent and pace of such cuts should continue to be data-dependent, consider the lagged effects of BI’s actions already taken, and account for the supportive fiscal impulse and the need to preserve space against external shocks. Continuing exchange rate flexibility will help to absorb shocks. Under the IMF’s Integrated Policy Framework, foreign exchange intervention could be part of the policy response given Indonesia’s relatively shallow foreign exchange markets, in case of risk-off shocks that trigger excessive tightening of financial conditions. Such interventions would need to balance the need to preserve buffers in a shock-prone world. A preliminary assessment of Indonesia’s external position in 2025 finds it is broadly in line with the level implied by medium-term fundamentals and desirable policies.

“The financial system is broadly resilient. Amid a negative credit gap, a near-term accommodative macroprudential stance is appropriate. Looking forward, gradually starting a shift towards a neutral stance as credit growth builds pace would safeguard against potential macro-financial risks. As the government seeks to mobilize the financial sector for its growth agenda, ensuring appropriate guardrails will help maintain the sector’s resilience.

“Indonesia remains firm in its “Golden Vision” of becoming a high-income country by 2045. To achieve it, authorities have targeted higher growth through a supportive macro policy mix, and expanding state-led initiatives, including the downstreaming and self-sufficiency agendas. Raising long-term growth durably and inclusively will require ambitious horizontal structural reforms—including on infrastructure, deregulation, reducing trade barriers, and further enhancing global integration—boosting the supply side of the economy and helping generate strong MSMEs, higher FDI and a dynamic private sector. Closing physical, human capital (education and skills) and institutional (governance and anti-corruption) gaps will also be critical to increase long-term growth and lift productivity. Staff analysis show that significantly deepening trade integration efforts with major partners—with a focus on reducing non-tariff barriers with complementary structural reforms to boost productivities across sectors, could be an important driver in Indonesia’s goal to reach high-income status. Recent proactive effort to engage with a broad range of trading partners to leverage global markets through a reduction of tariffs and non-tariff barriers as well as FDI facilitation have successfully delivered on the recent announcement of important agreements (Canada, EU-CEPA), while a potential deal with the US is well advanced. While full details and implementation of these agreements are pending, these efforts constitute an important step towards delivering growth and productivity gains.

“The IMF team met with officials in the government, Bank Indonesia, Financial Services Authority (OJK), other public agencies and representatives of the private sector and civil society. The team would like to thank the authorities and other interlocutors for the transparent and constructive discussions, as well as for excellent logistical support.”

ServiceNow Inc. (NYSE:NOW) is among the most fantastic stocks every investor should pay attention to. On October 30, BMO Capital analyst Keith Bachman reiterated his Buy rating on the company with an unchanged price target of $1,150, following the company’s Q3 2025 results a day earlier.

While Bachman called the Q3 results strong, with both subscription revenue and current remaining performance obligations (cRPO*) surpassing expectations, subscription revenue growth guidance for Q4 was below expectations. However, he believes that ServiceNow’s expanding AI capabilities and well-established portfolio position it for continued momentum.

The analyst also argued that the company’s growth is sustainable, given its ability to win large deal sizes, achieve higher attach rates, and maintain a healthy sales pipeline. His conviction is further supported by the management’s raised guidance for cash flow generation, including higher operating and free cash flow margins, as well as subscription revenue.

In its Q3 results, ServiceNow Inc. (NYSE:NOW) experienced broad-based demand across the platform and solid execution, which contributed to a 20.5% year-over-year growth in subscription revenue (on a constant currency basis) to $3.3 billion. RPO increased by 23% to $24.3 billion, and cRPO rose 20.5% to $11.35 billion, driven by strong momentum in industries such as transportation, logistics, retail, and hospitality. Supported by improved operating leverage, adjusted operating margin expanded by 250 basis points year-over-year to 33.5%, leading to an adjusted EPS of $4.82, which came in 13% ahead of consensus.

ServiceNow Inc. (NYSE:NOW) also announced that its board has authorized a 5-for-1 stock split, which will be submitted to shareholders for approval at a special meeting on December 5. The split is expected to increase the stock’s appeal and make the stock price more affordable for investors who wish to gain exposure to AI through the company.

As for the share price, the performance has been weak so far, with a YTD decline of nearly 19%.

*cRPO—contract revenue that will be recognized as revenue in the next 12 months

ServiceNow Inc. (NYSE:NOW) provides cloud-based platforms for digital workflows, enabling organizations to automate and optimize their business processes. The company’s Now Platform offers solutions across IT service management, customer service, HR, and other areas.

While we acknowledge the potential of NOW as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

(Bloomberg) — A resurgence in tech shares spurred a rebound in stocks, though the advance was limited by concerns over the Federal Reserve’s ability to slash interest rates in December. Bonds fell.

The relief brought by the end of the US shutdown quickly gave way to volatility this week as a host of Fed speakers threw cold water on bets for further policy easing. Hot areas favored by momentum traders such as artificial-intelligence and Bitcoin whipsawed. While the S&P 500 erased a 1.4% slide, most of its shares fell. Nvidia Corp. rallied ahead of its earnings.

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The outlook for lower rates favoring Corporate America alongside booming AI prospects have powered a torrid surge since the April meltdown, making many traders look past high valuations to keep chasing the market higher.

Earnings for most big tech companies have been in line or above expectations, though the outlook has been murky when it comes to where borrowing costs are headed. As Nvidia gets ready to report Wednesday, options traders are pricing in a 6.2% stock swing in either direction – its highest implied move in a year.

“Its earnings will be a huge test for the markets and the AI-trade, and could either ease fears about AI valuations or inflame them considerably,” said Kyle Rodda at Capital.com.

Also next week, big box retailers like Walmart Inc. and Target Corp. will report their results, offering a read on the state of consumer spending – the main engine of the American economy.

The S&P 500 rose to 6,760 after briefly falling below its 50-day moving average. A gauge of megacaps halted a three-day rout.

The yield on 10-year Treasuries climbed two basis points to 4.14%. The dollar wavered. Bitcoin almost erased this year’s gain.

UK markets got hit as speculation about the budget heightened uncertainty over the nation’s finances. Oil climbed as geopolitical risks mount from Russia to Iran.

“Stocks should bounce back here, but the dip buyers have been burned lately, so it might be a slow move back up to regain confidence,” said Bob Lang founder of Explosive Options.

We also saw some pretty clear rotation this week into health care primarily and consumer staples – looking like they have bottomed, according to Ken Mahoney at Mahoney Asset Management.

“Not really what you want to see if you are in the AI trade or adjacent stocks,” Mahoney said. “This is a unique circumstance where it feels like a mini bear market in some stocks” even though the S&P 500 is not that far from its highs.

“The general trend has been to buy the dip, which could provide a respite,” said Melissa Brown at SimCorp. “Retail investors may be spooked temporarily, but are likely to come back in if they believe the long-term story driving many of the names that have been gutted remains intact.”

Brown notes that a real rebound, though, may have to wait until government data starts flowing again and investors get a better read on the state of the economy and inflation.

“But it will only be a recovery if the economy continues to grow and inflation does not,” she said.

A slew of Fed officials have in recent days expressed skepticism over the need for another cut in December, or outright opposed one. It remains unclear whether they can persuade enough voting members of the Federal Open Market Committee, given that a number of policymakers are still more worried about job weakness.

Financial markets have taken note of the volume of comments coming recently from the Fed’s so-called inflation hawks. Investors have marked down the odds of a rate cut in December to less than 50%, based on federal funds futures contracts. Before the Fed’s October meeting, they were almost fully pricing in a reduction.

Their remarks came less than a month after Chair Jerome Powell warned that a December cut is far from a “foregone conclusion.”

“The tough but business-as-usual wrestling match over a December rate cut risks morphing into a crisis of governance at the Fed, with implications that extend well beyond whether it does or does not cut then,” said Krishna Guha at Evercore. “Absent miraculous clarification from limited data, Powell is in a rough spot. We urge cool heads and compromise.”

Guha says that he still leans toward a “hawkish cut,” but the odds have diminished.

“Our expectation for a soft October employment report and under-control October core CPI inflation should settle the internal debate at the FOMC in favor of an additional 25 basis-point rate cut. With that said, the decision is likely to be contentious, with a high possibility of additional hawkish dissents,” said Gennadiy Goldberg at TD Securities.

Corporate Highlights:

Applied Materials Inc. suffered a sales decline last quarter and predicted another drop in the current period, though the chip-equipment maker sees demand improving in the second half of 2026. Google has offered to tweak its ad tech products to settle a European Union order after a near-€3 billion ($3.4 billion) antitrust penalty, stopping short of a partial breakup watchdogs favor. Walmart Inc. Chief Executive Officer Doug McMillon, who over a decade ushered the big-box behemoth into the Internet age, will retire in February. He’ll be replaced by US head John Furner — long viewed as the heir apparent. Warner Bros. Discovery Inc. amended the contract of Chief Executive Officer David Zaslav to ensure his stock options remain eligible to vest even if the media company is sold. Merck & Co. agreed to acquire Cidara Therapeutics Inc., a biotech company developing a flu treatment, as part of its ongoing efforts to make up for the upcoming patent loss of its blockbuster cancer drug Keytruda. Bristol Myers Squibb Co. fell after one of its most important experimental medicines appeared unlikely to benefit patients who had suffered a heart complication, another setback for the drugmaker’s product pipeline. Boeing Co. stands to win most of a major order from Flydubai for single-aisle aircraft, though Airbus SE still has a long-shot chance to pry some business from an airline that’s never ordered from the European planemaker. Emirates is planning to use SpaceX’s Starlink to upgrade the onboard Wi-Fi in its fleet, according to people familiar with the matter, even though the service isn’t currently approved by the government. BlackRock Inc. has agreed to pay up to €2 billion ($2.33 billion) to form a data center venture with Spanish engineering firm ACS SA. American Tower Corp. and European buyout firm EQT AB are among parties weighing bids for French tower company TDF Infrastructure, people with knowledge of the matter said. A group of First Brands Group creditors is demanding new, independent advisers for company units that issued nearly $2.5 billion in off-balance-sheet debt, claiming conflicts of interest threaten to disrupt the sprawling insolvency case of auto-parts maker. JBS NV, the world’s largest meat supplier, reported a quarterly operating loss at its US beef business as a shortage of cattle continues to hit margins at the unit. BHP Group Ltd. is liable to compensate hundreds of thousands of victims of a devastating dam collapse in Brazil, a London judge ruled, moving closer to a potential multi-billion dollar payout a decade after the disaster. Nu Holdings Ltd. said artificial intelligence features it started to deploy in Brazil helped the fintech increase credit-card limits for some clients, boosting third-quarter revenue and profit. Sigma Lithium Corp. stocks rose as investors focused on the company’s forecast to resume mining operations by the end of the month, despite another quarter of cash burn, lower sales and production volumes. Allianz SE, the German insurer that owns bond manager Pacific Investment Management Co., raised its outlook for full-year profit after third-quarter earnings rose, driven by its property-casualty insurance and asset management businesses. Siemens Energy AG substantially raised its mid-term financial targets on strong demand for gas turbines and data center equipment as well as restructuring progress at its Gamesa wind turbine unit. Richemont sales climbed as shoppers from the US to China snapped up the luxury group’s pricey Cartier and Van Cleef & Arpels jewelry. Jaguar Land Rover Automotive Plc swung to a £559 million ($735 million) quarterly loss and slashed its guidance after a cyberattack temporarily halted production at the UK’s largest automaker. Japan’s biggest banks raised their annual earnings targets to fresh records and announced plans to buy back shares, as trade fears subside and rising interest rates boost lending profitability. Some of the main moves in markets:

Stocks

The S&P 500 rose 0.3% as of 1 p.m. New York time The Nasdaq 100 rose 0.4% The Dow Jones Industrial Average fell 0.4% The MSCI World Index was little changed Bloomberg Magnificent 7 Total Return Index rose 0.5% The Russell 2000 Index rose 0.5% Currencies

The Bloomberg Dollar Spot Index was little changed The euro fell 0.2% to $1.1614 The British pound fell 0.3% to $1.3157 The Japanese yen was little changed at 154.64 per dollar Cryptocurrencies

Bitcoin fell 2.9% to $95,893.01 Ether was little changed at $3,180.38 Bonds

The yield on 10-year Treasuries advanced two basis points to 4.14% Germany’s 10-year yield advanced three basis points to 2.72% Britain’s 10-year yield advanced 14 basis points to 4.57% The yield on 2-year Treasuries advanced one basis point to 3.60% The yield on 30-year Treasuries advanced three basis points to 4.74% Commodities

West Texas Intermediate crude rose 2.5% to $60.18 a barrel Spot gold fell 1.7% to $4,099.38 an ounce ©2025 Bloomberg L.P.

(Reuters) -JPMorgan Chase has secured deals that will ensure it receives payments from fintech companies for access to its customer bank account data ​by third-party apps, CNBC reported on Friday, citing sources familiar with ‌the matter.

The agreements were struck with data aggregators including Plaid, Yodlee, Morningstar and Akoya, Drew Pusateri,‌ a JPMorgan Chase spokesperson, told Reuters.

Data aggregators are intermediaries who link banks with fintech firms. They previously accessed customer account data from banks such as JPMorgan without paying for it, enabling fintech apps to offer services like budgeting and payments – an arrangement that drew ⁠criticism from lenders concerned about data ‌security and fair compensation.

“The free market worked. After productive conversations with our aggregator and fintech partners, we’ve come to agreements that ‍will make the open banking ecosystem safer and more sustainable – and allow customers to continue reliably and securely accessing their favorite financial products,” Pusateri added.

The deals follow weeks of talks between ​the largest U.S. bank and the aggregators, with JPMorgan agreeing to a ‌lower fee than initially proposed and fintech intermediaries securing concessions on how data requests are handled, the CNBC report added.

The Consumer Financial Protection Bureau’s (CFPB) “open banking” rule, introduced last year under the Biden administration, set standards for data sharing between fintechs and banks, enabling consumers to move personal financial data between providers at no ⁠cost.

Banks, facing potential losses, swiftly criticized the ​rule, arguing it risked consumer data security and ​overstepped the agency’s authority, while fintech firms welcomed it, saying it would enable secure sharing of consumer data.

The CFPB kicked off a do-‍over of its “open ⁠banking” regulations in August, amid public pressure from fintech firms and crypto entrepreneurs.

The Trump administration had initially sided with a banking industry call to scrap the ⁠regulations entirely, claiming they exceeded the agency’s legal powers, before changing tack earlier in the year,‌ citing “recent events in the marketplace.”

(Reporting by Pritam ‌Biswas in Bengaluru; Editing by Maju Samuel)