HOUSTON and LONDON, Dec. 29, 2025 (GLOBE NEWSWIRE) — Baker Hughes (NASDAQ: BKR) will announce the results of the fourth quarter and full year ending Dec. 31, 2025, via press release at 5 p.m. Eastern Time (4 p.m. Central Time) on Sunday, Jan. 25, 2026. A webcast to discuss the results will be held Monday, Jan. 26, at 9:30 a.m. Eastern Time (8:30 a.m. Central Time).
To access the webcast, listeners should visit the Baker Hughes website at: investors.bakerhughes.com. An archived version will be available on the website following the webcast.
About Baker Hughes Baker Hughes (NASDAQ: BKR) is an energy technology company that provides solutions to energy and industrial customers worldwide. Built on a century of experience and conducting business in over 120 countries, our innovative technologies and services are taking energy forward – making it safer, cleaner and more efficient for people and the planet. Visit us at bakerhughes.com.
The combination of CDK4/6i and ET has reshaped treatment for HR+/HER2– breast cancer (Johnston et al., 2019; Finn et al., 2015; Finn et al., 2016; Turner et al., 2018; Dickler et al., 2017; Hortobagyi et al., 2022; Slamon et al., 2020; Im et al., 2019). However, resistance commonly emerges, and no consensus second-line standard is established. Our data show that continued CDK4/6i treatment in drug-resistant cells engages a noncanonical, proteolysis-driven route of Rb inactivation, yielding attenuated E2F output and a pronounced delay in G1 progression (Figure 7G). Concurrent ET further deepens this blockade by suppressing c-Myc-mediated E2F amplification, thereby prolonging G1 and slowing population growth. Importantly, CDK2 inhibition alone was insufficient to control resistant cells. Robust suppression of both CDK2 activity and resistant-cell growth required CDK2i in combination with CDK4/6i, consistent with prior reports supporting dual CDK targeting (Pandey et al., 2020; Freeman-Cook et al., 2021; Dietrich et al., 2024; Al-Qasem et al., 2022; Kudo et al., 2024; Arora et al., 2023; Kumarasamy et al., 2025; Dommer et al., 2025). Moreover, cyclin E blunted the efficacy of the CDK4/6i+CDK2i combination by reactivating CDK2. Together, these findings provide a mechanistic rationale for maintaining CDK4/6i beyond progression and support testing the combination of CDK4/6i and CDK2i, as evidenced by concordant in vitro and in vivo results.
Our data indicate that maintaining both CDK4/6i and ET synergistically decelerates cell-cycle progression in drug-resistant cells by further delaying CDK2 activation kinetics and the G1/S transition without affecting the S and G2 phases. This dual effect stems from CDK4/6i causing suboptimal Rb inactivation, while ET suppresses the global transcription amplifier c-Myc, collectively leading to diminished E2F transcriptional activity. As a result, this reduced E2F activity lowers the expression of critical cell-cycle genes, such as cyclin E and A, extending the time needed for CDK2 activation. Given that CDK2 plays an essential role in initiating and advancing DNA replication (Tanaka et al., 2007; Krude et al., 1997), its delayed activation significantly prolongs the G1/S transition. Moreover, CDK2 activation also contributes to Rb phosphorylation and inactivation. High CDK2 activity is required to phosphorylate Rb, and CDK2-mediated Rb phosphorylation is tightly coupled with DNA replication timing (Kim et al., 2022; Chung et al., 2019). Thus, upon Rb phosphorylation by CDK2 at the G1/S transition, drug-resistant cells may effectively proceed through the cell cycle even under continued CDK4/6i treatment.
Clinical trials evaluating the efficacy of sustained CDK4/6i therapy predominantly use PFS as the primary endpoint (Llombart-Cussac et al., 2025; Mayer et al., 2024; Kalinsky et al., 2025; Jhaveri et al., 2025; Kalinsky et al., 2023). However, our findings suggest that drug-resistant tumors continue to proliferate despite CDK4/6i maintenance. Consequently, maintaining CDK4/6i appears to slow tumor growth rather than completely arrest it. This underscores the need for clinical trials to consider overall survival and tumor progression rates as more appropriate endpoints for assessing the true benefits of sustained CDK4/6i therapy. Furthermore, the distinct polypharmacology profiles among CDK4/6i (Hafner et al., 2019), with ribociclib being the most specific and abemaciclib the least, may explain the varying therapeutic outcomes observed among these inhibitors (Kalinsky et al., 2023; Navarro-Yepes et al., 2023).
Maintaining CDK4/6i treatment beyond progression may be particularly beneficial for about 70% of patients who do not acquire new genetic mutations (O’Leary et al., 2018). However, it is important to recognize that resistance to CDK4/6i often arises from mutations in genes associated with mitogenic or hormone-signaling pathways (O’Leary et al., 2018; Mao et al., 2020; Wander et al., 2020; Formisano et al., 2017; Costa et al., 2020). These include mutations in PIK3CA, ESR1, FGFR1–3, and HER2, which have been linked to increased c-Myc expression (Shang et al., 2000; Zhu et al., 2008; Tsai et al., 2012). Additionally, previous studies have identified FAT1 mutations as a driver of CDK4/6i resistance (Li et al., 2022; Li et al., 2018). These resistance mutations may reduce the efficacy of maintaining CDK4/6i and ET therapy. Moreover, about 4.7% of HR+/HER2– breast cancer patients exhibit Rb mutations (O’Leary et al., 2018; Wander et al., 2020), making CDK4/6i treatment unlikely to be effective, thus making its continuation inadvisable in these cases.
In conclusion, our study provides mechanistic rationale for maintaining CDK4/6i together with ET after disease progression in HR+/HER2– breast cancers that retain an intact Rb/E2F pathway. The combination of CDK4/6i and CDK2i can further provide durable growth suppression, consistent with prior studies (Pandey et al., 2020; Freeman-Cook et al., 2021; Dietrich et al., 2024; Al-Qasem et al., 2022; Kudo et al., 2024; Arora et al., 2023; Kumarasamy et al., 2025; Dommer et al., 2025). However, it is essential to acknowledge that CDK2/4/6 inhibition may promote whole-genome duplication (Kim et al., 2025a), potentially fueling more aggressive tumor evolution. Finally, we identify cyclin E overexpression as a key driver of resistance to dual CDK4/6i and CDK2i therapy, providing a basis for biomarker-guided patient selection and the development of strategies to overcome therapeutic resistance.
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Sale Savings: From 29th December until 4th February, new broadband customers can take advantage of a range of exciting deals in Virgin Media’s winter sale.
Award-Winning Reliability: Those switching to Virgin Media, recognised by Uswitch as the UK’s Most Reliable Broadband Provider, can benefit from the company’s market leading WiFi guarantee of 30Mbps in every room or £100 credit*.
Netflix Included: All Virgin Media TV bundles now include Netflix Standard at no extra cost.
Priority from O2: Customers with Virgin Media broadband can unlock access to a range of exclusive rewards and experiences via the Priority app (with rewards worth £339 on average each year, according to Uswitch).
From 29th December until midnight on 4th February, new customers looking to boost their connectivity and entertainment line-up can benefit from new offers in Virgin Media’s Winter Sale.
Those who switch to Virgin Media – recognised by Uswitch as the UK’s ‘Most Reliable Broadband Provider’ (Opensignal Awards – UK: Fixed Broadband Experience Report, Dec 2025), can enjoy ultrafast (500mbps) speeds from £29.99 per month, including Netflix Standard available with all TV bundles at no extra cost – saving £5.99 a month.
Broadband package
What is included
Cost per month (18-month contract)
M250
Broadband: Average download speeds of 264Mbps
£23.99 for per month
M500
Broadband: Average download speeds of 516Mbps
£27.99 for per month
M500 + Netflix
Broadband: Average download speeds of 516MbpsTV: Netflix Standard (with Ads)
£29.99 for per month
Gig1
Broadband: Average download speeds of 1,130Mbps
£30.99 for per month
M350 Entertainment + Netflix
Broadband: Average download speeds of 362MbpsTV: 200+ TV channels & Netflix Standard (with Ads)
£34.99 for per month
M350 Cinema + Netflix
Broadband: Average download speeds of 362MbpsTV: 200+ TV channels including Sky Cinema & Netflix Standard (with Ads)
£44.99 for per month
M350 Sport (HD) + Cinema (HD) + Netflix
Broadband: Average download speeds of 362MbpsTV: 200+ TV channels including Sky Sports HD, Sky Cinema HD & Netflix Standard (with Ads)
£64.99 for per month
Gig1 Max Volt: Sports (HD) + Cinema (HD) + Netflix + Unlimited O2 SIM
Broadband: Average download speeds of 1,130MbpsTV: 200+ TV channels including Sky Sports HD, Sky Cinema HD & Netflix Standard (with Ads) SIM-Only: O2 Travel Inclusive Zone (75 destinations)WiFi Guarantee: Up to 30Mbps in every room of £100 back, usually £8 per month
£79.99 for per month
Customers with an O2 mobile account who add Virgin Media broadband to their household services can also enjoy Volt rewards worth up to £692 (according to Choose Broadband). These rewards include:
Double mobile data on all eligible O2 mobile Plans in the household i.e. if a customer has 10GB as part of their mobile Plan, they’ll get a boost to 20GB data for no extra cost.
A broadband speed boost to the next available tier (up to 1Gbps) e.g. boosted from 100Mpbs to 200Mpbs at no extra cost.
The UK’s market-leading WiFi guarantee which offers minimum download speeds of 30Mbps in every room or £100 credit back.
In addition to Virgin Media’s award-winning broadband, customers also get:
Priority from O2: Virgin Media broadband and O2 customers can enjoy access to Priority, which according to price comparison website, Uswitch, offers members a range of rewards worth over £339 each year**. Through Priority, members can enjoy exclusive rewards, unique experiences and daily treats, as well as 48-hour early access to thousands of nationwide gigs and events, through Priority Tickets.
Essential Security: Included in all Virgin Media broadband packages at no extra cost, Essential Security is cyber security software designed to block potentially harmful content, provide adjustable parental controls and offer built in protection to help keep users safe a from attempted cyber threats.
Refer a friend: Customers who refer a friend can also receive a £50 bonus per recommendation. When the referred friend has had their services installed for 60 days, they will then both be eligible for the reward. will be eligible for a reward providing they’ve not cancelled their new contract within this time.
Fast, reliable service: According to Uswitch**, Virgin Media customers can enjoy the highest average download speeds of all internet providers, so whether they’re gaming, working or streaming a new show, the whole household can enjoy a fast and reliable service simultaneously.
One Touch Switch: Switching to Virgin Media has never been easier under the industry’s new One Touch Switch process, with customers simply needing to go online or call direct, choose the package they would like and let Virgin Media do the rest – they don’t even have to contact their existing provider about the switch.
ENDS
Notes to Editor
For more info please see: Broadband and TV Deals | Winter Sale | Offer Ends Soon
*Virgin Media’s market leading WiFi guarantee WiFi Max: What is it and how to get it? | Virgin Media Help
** UK Broadband Speed Statistics 2024 – Facts and Stats Report – Uswitch
Refer a friend: £50 bonus eligible once referred customer has had their services installed for 60 day, and providing they haven’t cancelled their services during that time.
BANGKOK — Shares in Europe and Asia were mostly lower in thin holiday trading as China staged military exercises near the island of Taiwan.
The prices of gold and silver fell back after recent gains, while oil prices jumped more than $1. U.S. futures were little changed.
Shares in Taiwan were higher even after China’s military said it was conducting the drills around the self-governed island that Beijing claims as its territory.
In early European trading, Germany’s DAX slipped 0.2% to 24,296.81, while the CAC 40 in Paris was nearly unchanged at 8,100.83. Britain’s FTSE 100 likewise barely budged, at 9,874.80.
The future for the S&P 500 fell 0.2% while that for the Dow Jones Industrial Average was flat.
China said its combined forces drills were intended to warn against what it called separatist and “external interference” forces. Taiwan placed its military on alert and called the Beijing government “the biggest destroyer of peace.”
The drills came after Beijing expressed anger at U.S. arms sales to the territory. That followed a comment by Japanese Prime Minister Sanae Takaichi that Japan’s defense forces could get involved if China were to take action against Taiwan. The Chinese statement did not mention the United States and Japan.
Taiwan’s benchmark Taiex gained 0.9%, but the Hang Seng in Hong Kong gave up early gains, falling 0.7% to 25,635.23. The Shanghai Composite index was virtually unchanged at 3,965.28.
Tokyo’s Nikkei 225 slipped 0.4% to 50,526.92.
In South Korea, the Kospi jumped 2.2% to 4,220.56, less than 2 points off its all-time record reached in early November. A 6.8% jump for SK Hynix due to a regulatory change that lifted an investment warning for its stock helped boost the benchmark. Samsung Electronics advanced 2.1%.
Australia’s S&P/ASX 200 gave up 0.4% to 8,725.70.
The price of gold fell 1.3% to $4,494 per troy ounce, while silver slipped 2.3% to $75.40. It has jumped to record levels on supply constraints, as both precious metals have been favored by investors seeking safe havens outside of stocks and bonds.
Earlier surges in gold prices also partly reflected worries during the U.S. government shutdown. Expectations that the U.S. Federal Reserve will cut interest rates further in the new year, weakening the dollar against other currencies, have further fueled buying of gold.
Silver, which like gold is used in many industries, has been influenced by other factors, too. China, which refines about two-thirds of global supplies, has scrapped an export quota system, replacing it with an export licensing system effective Jan. 1.
“Scarcity is no longer theoretical,” Stephen Innes of SPI Asset Management said in a report. “China sits at the center of global silver refining, and when the world’s top refiner starts tightening the valve, downstream users feel it immediately.”
Reopening Friday from the Christmas holiday, the S&P 500 index fell less than 0.1% and the Dow Jones Industrial Average also fell less than 0.1%. The Nasdaq composite fell 0.1%.
With three trading days left in 2025, the S&P 500 has climbed nearly 18% this year, helped by the deregulatory policies of the Trump administration and investor optimism about the future of artificial intelligence.
Trading has been light, with institutional investors largely closed out for the year.
In other dealings early Monday, U.S. benchmark crude oil gained $1.13 to $57.87 per barrel, while Brent crude, the international standard, advanced $1.13 to $61.37 per barrel. On Friday, U.S. crude oil fell 2.8% and Brent crude fell 2.6%.
The U.S. dollar fell to 156.30 Japanese yen from 156.56 yen. The euro rose to $1.1779 from $1.1770.
If you want an outdoor public pool in your community, you and your neighbours should demand one.
That’s the lesson learned from Saskatoon’s history, according to information supplied by the city’s archivist, Jeff O’Brien.
Three of Saskatoon’s existing outdoors pools were built in response to public campaigns, and pressure from residents helped save two of the pools from closure.
“I’m glad they’re keeping the pool,” Diane Deptuck told the Saskatoon StarPhoenix in July 2009 as Mayfair Pool turned 50 years old. “There are too many children around here who have nothing to do all day.”
Deptuck, who had taken her six-year-old grandson to the pool as its shelf life was ending, recalled teaching her daughter to swim in Mayfair Pool. But it was leaking and Deptuck described the state of the change rooms as “horrid” for the last 15 years, specifically decrying the “stench.”
The pool reopened in 2012 after a $4.8-million refresh. That was the second time it had been slated for closure and then resurrected. In the early 1990s, it was identified as a candidate for closure, but public pressure kept it open — even the “horrid” change rooms.
Like Saskatoon’s Lathey and George Ward pools, Mayfair was built in direct response to community pressure. A petition with 10,000 names was presented to city council in 1958 and Mayfair Pool opened on July 4, 1959. It cost $166,514, a sliver of the price of its rehabilitation 50 years later.
Now it’s George Ward’s turn to go through the same debate. The Holliston neighbourhood pool marked 60 years of operation on July 1, but it’s actually the newest in terms of its debut.
George Ward was built for $225,000 after a petition with 8,000 signatures was presented to council in 1963. That petition included the suggestion the pool be named for Ward, the city’s recreation director.
Last month, the closure of George Ward was presented to council among 108 options to reduce the property tax increase. Council never even voted on the proposal, which would have saved $152,000 in annual operational costs.
Likewise, council punted options to reduce the outdoor pool season and the hours the pools are open. A motion to increase the cost of admission was defeated 9-2.
City manager Jeff Jorgenson acknowledged that some of the proposals to reduce the tax hike were “unpalatable.”
But a city report says George Ward will need to be replaced in five years, and no funding or plan exists to accomplish that.
Sixty years ago, when the youngest of the city’s pools first opened, Saskatoon had grown to about 115,000 people. The population has nearly tripled since then, but no new outdoor pools have been built. The city now boasts 67 neighbourhoods, but just four outdoor pools.
People enjoy Riversdale Pool in Saskatoon, Sask. in an archive photo (1048-0402) taken in 1963. (City of Saskatoon)
A century of splashes
Riversdale Pool, which cost $16,283.31 to build originally, marked a century since its debut in July. But it has been almost completely replaced over that period, including adding a waterslide in 1986 for $150,000 and replacement of the basin in 1995 for $1.4 million.
Lathey Pool closed for four years starting in 1985 after the city decided it needed to be replaced. Saskatoon’s second outdoor pool, the first to be built on the east side of the South Saskatchewan River, cost $155,000 to build and opened in 1955.
The cost of replacing it was just shy of $1 million.
Michael Roma, a managing partner with RC Strategies, an Edmonton-based consulting company that focuses on community services, said building an outdoor pool today can cost $20 million or more.
Combine that with the short season — Saskatoon pools open in June and close by September — and it’s difficult to justify, Roma said in a recent interview.
“You’re not making money off of any pool, for sure,” he said. “There’s an investment or subsidy that has to go into it.”
Changing weather patterns and new hazards like heavy smoke from wildfires linked to climate change can further reduce the “social return” from such an investment, which already has limited availability, he said.
Indoor pools can cost three times as much, but it can be easier to justify the cost because they’re available far more often, Roma said.
“Even though [outdoor pools are] cheaper [to build,] even though they are popular. Like, you can’t argue with the nostalgia of walking through a neighbourhood and hearing kids splash around in an outdoor pool.”
Saskatoon has added other, cheaper summer amenities like spray pads, which number 23, and 30 paddling pools.
Roma stopped short of saying outdoor pools could one day disappear from the Prairies, but he said the availability per capita will continue to shrink.
“I can’t speak to why there are any outdoor pools in the Prairies, but if you made a case against an outdoor pool, it would probably be stronger in the Prairie provinces than most places in the world.”
An archive photo of George Ward Pool (1048-0458) taken when it first opened in 1965 in Saskatoon, Sask. (City of Saskatoon)
That sinking feeling
Part of the problem is that population growth does not generally pay for major facilities through development levies, which is why new venues do not appear when a city experiences a major influx of people like Saskatoon, he said.
Cities struggle just to pay for maintenance and operation of existing amenities.
“There’s an affordability train that is going to hit a wall.”
Roma’s company has crafted strategic plans for recreation facilities for both Saskatoon and Regina. The Regina plan identified two outdoor pools in need of replacing, the same dilemma looming for George Ward in Saskatoon.
Regina city hall announced in late 2018 a plan to rebuild the then-71-year-old Wascana Pool for $16.5 million and permanently close the 72-year-old Maple Leaf Pool in the city’s Heritage neighbourhood.
But people showed up at Regina budget talks in 2018 to voice their opposition to closing Maple Leaf Pool. Eventually, it was demolished and rebuilt for $6.2 million in response to passionate residents determined to keep their beloved outdoor amenity.
Regina still boasts five outdoor public pools compared to just four in Saskatoon, which has more than 50,000 additional residents. Edmonton, with more than three times the population of Saskatoon, only has five outdoor pools.
Reisha Peters, president of the Holliston Community Association, told Saskatoon Morning last month that she was “a little heartbroken” to hear George Ward Pool might close. She takes her own children there for swimming lessons.
She said the loss of one of Saskatoon’s pools would place enormous pressure on the other three.
“Lathey Pool, in particular,” Peters said. “If it’s a hot day, you might be waiting an hour in line just to get in, and especially with little kids, that’s a big ask.”
An agonizing decision on either closing or spending millions to revitalize George Ward Pool awaits Saskatoon city council in the coming years.
In Moose Jaw, a plan to replace an outdoor pool of the same vintage as George Ward is estimated to cost about $13 million with no funding plan in place.
But how pools are built has changed since the original was built, including much better mechanical systems and tunnels around the basin to make repairs easier. Those advances can reduce the cost of maintenance and operations.
Roma said expectations for an outdoor pool have also grown beyond a rectangular tank, however. People now want waterslides, hot tubs and other amenities.
“People expect something different now than they would have in the ‘60s.”
HOD HASHARON, Israel, Dec. 29, 2025 /PRNewswire/ — Valens Semiconductor (NYSE: VLN), a leader in high-performance connectivity, today released its fourth annual Environmental, Social and Governance (ESG) Report. The 2024 Report details the Company’s progress, commitment, and approach as it looks to advancing a sustainable future.
Valens Semiconductor Releases its Environmental, Social and Governance (ESG) 2024 Report
Valens Semiconductor’s mission is to develop leading-edge products that enable robust, ultra-high-performance wired connectivity over simple, cost-effective infrastructure for a variety of markets, including professional audio-video, automotive, industrial machine vision, and medical.
“We are pleased to share Valens Semiconductor’s fourth annual ESG Report, which provides an update on our ongoing commitment to our key ESG initiatives and the progress we achieved in 2024,” said Yoram Salinger, CEO of Valens Semiconductor. “We are dedicated to advancing core ESG principles that guide our operations and support stakeholder expectations. Significant progress has been made in improving energy efficiency, reducing electricity consumption and combined Scope 1 and Scope 2 GHG emissions, and expanding electronic waste recycling efforts”.
“Our 2024 ESG Report highlights our commitment to ethical and transparent governance while supporting continued business growth. Through active engagement with shareholders, customers, and partners, we communicate our progress and outlook as we advance connectivity solutions while promoting a healthier environment, employee well-being, and community engagement” said Igal Rotem, Chairman of Valens Semiconductor’s Nominating, Governance, and Sustainability Committee.
The report can be found via the investor relations section of Valens Semiconductor’s website at Valens – ESG-ESG Reports, or by clicking here.
About Valens Semiconductor
Valens Semiconductor (NYSE: VLN) is a leader in high-performance connectivity, enabling customers to transform the digital experiences of people worldwide. Valens’ chipsets are integrated into countless devices from leading customers, powering state-of-the-art audio-video installations, next-generation videoconferencing, and enabling the evolution of ADAS and autonomous driving. Pushing the boundaries of connectivity, Valens sets the standard everywhere it operates, and its technology forms the basis for the leading industry standards such as HDBaseT® and MIPI A-PHY. For more information, visit https://www.valens.com/.
Investor Contacts:
Michal Ben Ari Investor Relations Manager Valens Semiconductor Ltd. [email protected]
Miri Segal MS-IR IR for Valens Semiconductor Ltd. [email protected]
China’s rocket startup LandSpace set to challenge Elon Musk’s SpaceX
While tech billionaire Elon Musk seems to be reigning supreme in the realm of aerospace technology, China’s rocket startup LandSpace is establishing itself as a competitor against Musk’s SpaceX.
It is widely believed that the Chinese space tech firm draws inspiration from SpaceX’s innovative approach. It became the first Chinese company to conduct a reusable rocket test earlier this month.
The contender is challenging the Musk-owned aerospace and space transportation company with remarkable strides reflecting its ambitions.
Although the Zhuque-3 rocket test ended in failure, LandSpace’s objective to become a leader in reusable rockets is energising China’s space industry, which was mostly dominated by risk-averse state-owned entities.
Zhuque-3 chief designer Dai Zheng noted that his decision to join LandSpace was influenced by SpaceX’s focus on reusability and rapid iteration.
LandSpace aims to provide China with a low-cost launch option like SpaceX’s Falcon 9 rocket, which is critical for Beijing’s plans to establish 10,000 satellite constellations in the coming decades.
LandSpace’s startup culture signifies a huge shift in China’s space programme, which has historically shied away from failures.
As per reports churned out by China’s state media outlets, failed attempts by both LandSpace and state-owned firms indicate a changing attitude towards risk in the industry.
As LandSpace is gearing up for another launch after the December failure of Zhuque-3, it seems relieved through SpaceX’s experience.
How LandSpace’s scenario draws comparison with SpaceX is that SpaceX’s first successful Falcon booster landing came after two unsuccessful attempts, illustrating the value of persistence in the pursuit of innovation.
To go public and attract investment, LandSpace seems adamant about carving out its niche in the landscape of commercial spaceflight and transforming the future of China’s space endeavours.
