Lundin Mining Announces an Update Regarding the 2017 Class Action
November 28, 2025
VANCOUVER, BC, Nov. 28, 2025 /CNW/ – (TSX: LUN) (Nasdaq Stockholm: LUMI) Lundin Mining Corporation (“Lundin Mining” or the “Company”) announces that it has received a ruling from its appeal to the Supreme Court of Canada. The ruling upholds the 2023 Ontario Court of Appeal decision allowing a proposed securities class action to be commenced relating to the timing of disclosure of a 2017 pit wall instability and rockslide at the Candelaria Mine in Chile. The certified class action can now proceed before the Ontario Superior Court of Justice. There has been no decision on the merits of the case, and the Company intends to vigorously defend the action.
Background
Lundin Mining disclosed the pit wall instability and rockslide in its normal course operational update to investors on November 29, 2017. The claim alleges that these events should have been disclosed earlier. The decision regarding leave to proceed centered on the distinction between a “material fact” and a “material change” under the Ontario Securities Act.
About Lundin Mining
Lundin Mining is a diversified Canadian base metals mining company with projects or operations in Argentina, Brazil, Chile and the United States of America, and primarily producing copper, gold and nickel.
The information in this release is subject to the disclosure requirements of Lundin Mining under the Swedish Financial Instruments Trading Act. The information was submitted for publication, through the agency of the contact persons set out below on November 28, 2025 at 11:00 Pacific Time.
Cautionary Statement on Forward-Looking Information
Certain of the statements made and information contained herein are “forward-looking information” within the meaning of applicable Canadian securities laws. All statements other than statements of historical facts included in this document constitute forward-looking information, including but not limited to statements regarding the proposed securities class action against the Company related to the timing of disclosure of a 2017 pit wall instability and rockslide at the Candelaria Mine in Chile. Words such as “believe”, “expect”, “anticipate”, “contemplate”, “target”, “plan”, “goal”, “aim”, “intend”, “continue”, “budget”, “estimate”, “may”, “will”, “can”, “could”, “should”, “schedule” and similar expressions identify forward-looking information.
Forward-looking information is necessarily based upon various estimates and assumptions including, without limitation, the expectations and beliefs of management, including that the Company can access financing, appropriate equipment and sufficient labour; assumed and future price of copper, gold, zinc, nickel and other metals; anticipated costs; currency exchange rates and interest rates; ability to achieve goals; the prompt and effective integration of acquisitions and the realization of synergies and economies of scale in connection therewith; that the political, economic, permitting and legal environment in which the Company operates will continue to support the development and operation of mining projects; timing and receipt of governmental, regulatory and third party approvals, consents, licenses and permits and their renewals; positive relations with local groups; the accuracy of Mineral Resource and Mineral Reserve estimates and related information, analyses and interpretations; and such other assumptions as set out herein as well as those related to the factors set forth below. While these factors and assumptions are considered reasonable by Lundin Mining as at the date of this document in light of management’s experience and perception of current conditions and expected developments, such information is inherently subject to significant business, economic, political, regulatory and competitive uncertainties and contingencies. Known and unknown factors could cause actual results to differ materially from those projected in the forward-looking information and undue reliance should not be placed on such information. Such factors include, but are not limited to: dependence on international market prices and demand for the metals that the Company produces; political, economic, and regulatory uncertainty in operating jurisdictions, including but not limited to those related to permitting and approvals, nationalization or expropriation without fair compensation, environmental and tailings management, labour, trade relations, and transportation; operating jurisdictions, including but not limited to those related to permitting and approvals, nationalization or expropriation without fair compensation, environmental and tailings management, labour, trade relations, and transportation; risks relating to mine closure and reclamation obligations; health and safety hazards; inherent risks of mining, not all of which related risk events are insurable; risks relating to tailings and waste management facilities; risks relating to the Company’s indebtedness; challenges and conflicts that may arise in partnerships and joint operations; risks relating to development projects, including Filo del Sol and Josemaria; risks that revenue may be significantly impacted in the event of any production stoppages or reputational damage in Chile; the impact of global financial conditions, market volatility and inflation; business interruptions caused by critical infrastructure failures; challenges of effective water management; exposure to greater foreign exchange and capital controls, as well as political, social and economic risks as a result of the Company’s operation in emerging markets; risks relating to stakeholder opposition to continued operation, further development, or new development of the Company’s projects and mines; any breach or failure information systems; risks relating to reliance on estimates of future production; risks relating to litigation and administrative proceedings which the Company may be subject to from time to time; risks relating to acquisitions or business arrangements; risks relating to competition in the industry; failure to comply with existing or new laws or changes in laws; challenges or defects in title or termination of mining or exploitation concessions; the exclusive jurisdiction of foreign courts; the outbreak of infectious diseases or viruses; risks relating to taxation changes; receipt of and ability to maintain all permits that are required for operation; minor elements contained in concentrate products; changes in the relationship with its employees and contractors; the Company’s Mineral Reserves and Mineral Resources which are estimates only; uncertainties relating to inferred Mineral Resources being converted into Measured or Indicated Mineral Resources; payment of dividends in the future; compliance with environmental, health and safety laws and regulations, including changes to such laws or regulations; interests of significant shareholders of the Company; asset values being subject to impairment charges; potential for conflicts of interest and public association with other Lundin Group companies or entities; activist shareholders and proxy solicitation firms; risks associated with climate change; the Company’s common shares being subject to dilution; ability to attract and retain highly skilled employees; reliance on key personnel and reporting and oversight systems; risks relating to the Company’s internal controls; counterparty and customer concentration risk; risks associated with the use of derivatives; exchange rate fluctuations; the terms of the contingent payments in respect of the completion of the sale of the Company’s European assets and expectations related thereto; and other risks and uncertainties, including but not limited to those described in the “Risks and Uncertainties” section of the Company’s MD&A for the three and nine months ended September 30, 2025, the “Risks and Uncertainties” section of the Company’s MD&A for the year ended December 31, 2024, and the “Risks and Uncertainties” section of the Company’s Annual Information Form for the year ended December 31, 2024, which are available on SEDAR+ at www.sedarplus.ca under the Company’s profile.
All of the forward-looking information in this document is qualified by these cautionary statements. Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in forward-looking information, there may be other factors that cause results not to be as anticipated, estimated, forecasted or intended and readers are cautioned that the foregoing list is not exhaustive of all factors and assumptions which may have been used. Should one or more of these risks and uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those described in forward-looking information. Accordingly, there can be no assurance that forward-looking information will prove to be accurate and forward-looking information is not a guarantee of future performance. Readers are advised not to place undue reliance on forward-looking information. The forward-looking information contained herein speaks only as of the date of this document. The Company disclaims any intention or obligation to update or revise forward ‐ looking information or to explain any material difference between such and subsequent actual events, except as required by applicable law.
SOURCE Lundin Mining Corporation
For further information, please contact: Stephen Williams, Vice President, Investor Relations: +1 604 806 3074; Robert Eriksson, Investor Relations Sweden: +46 8 440 54 50
Ray started to remember why they left in the first place. And then abandoned it completely when they found an area that had more material to mine than just snow. They might as well finish what they started! Before they left, Ray raided all the chests they could find. Signs, signs, string, sighs, wool, signs, aaaaand… signs!
Back outside, the snow was still falling. Ray looked around, everything was flat and white. So they closed their eyes, spun around, and just started walking in that direction. And what a fine direction it was, because after a while Ray came face to face with another creature. It looked familiar, yet different. Horns facing the front, eyes you could get lost in, and covered in soft, warm wool. This cow seemed to have evolved perfectly for the cold climate.
What an icon. Ray needed to adopt it! They checked their inventory, but alas – not a single piece of wheat to be found. All they had was the dried ghast block and signs. They would have to do.
Ray cautiously approached the majestic beast and placed a sign nearby.
“Free wheat →”
The cow looked at the sign. The cow looked at Ray. The cow walked away.
Ray picked up the sign and placed it in front of the cow, but it kept walking. Maybe it had been burned by false promises before. Understandable. But Ray knew that even if they didn’t have any wheat now, they would absolutely get it! They just couldn’t risk losing the beautiful bovine like they had their base. So a little bit of deception would be necessary, and Ray would make up for it tenfold when they were both settled.
Moving as fast as they could through the cold snow, Ray started placing signs on both sides of the cow. They made sure each one bore the promise of wheat, just in case.
The cow, whom Ray had named Yarn, finally started to moo-ve through the crafted path. The plan was working! Hooray! Ray was so excited that they stopped paying attention to where they were going.
Exor holds largest stake in The Economist at 43.4%
Few opportunities to buy into British media empires
Rothschild stake sale could value Economist at £800 million, source says
NEW YORK/LONDON, Nov 28 (Reuters) – The sale of a large stake in the storied Economist publication is coming to a head this week, as bidders submit expressions of interest by Friday’s deadline for a 27% stake, three people familiar with the matter said.
At least a dozen parties, including ultra wealthy individuals and media companies, have already shown preliminary interest, one of the people said.
Sign up here.
It’s been a decade since anyone has been able to buy a share close to this size, not since Britain’s Pearson (PSON.L), opens new tab sold its 50% stake in 2015 to the holding group of the wealthy Italian Agnelli family, for 469 million pounds ($531 million), ending its near-60-year ownership in the magazine.
Philanthropist Lynn Forester de Rothschild is putting the banking dynasty’s share of The Economist up for sale three years after the death of her husband Evelyn de Rothschild, who chaired the company from 1972 to 1989, according to the people, who spoke on condition of anonymity because the matter is private.
Requests for comment from the Rothschild family and The Economist weren’t immediately returned.
Founded in 1843, the publication’s shareholding total nearly 1,000, with Exor, a holding vehicle for Italy’s Agnelli family, owning a 43.4% stake and the Rothschilds owning 27%, according to the Economist’s annual results.
The sale is made more complex as The Economist’s governance is structured to ensure the editorial process at the 182-year-old publication remains independent, prohibiting any one individual or company from owning a controlling stake in the corporate parent.
The sale of the Economist comes at a time when there are few opportunities to buy into highly coveted British media empires. The owner of the Daily Mail, DMGT, recently stepped in to scoop up the Telegraph Media Group after UK regulators banned foreign ownership of UK newspapers.
The move forced U.S.-based Redbird Capital to withdraw its 500 million pound ($658.5 million) joint bid with Abu Dhabi-backed IMI for the Telegraph.
The Economist is profitable and has been growing its subscriber base. First-half revenue for the six months ended Sept. 30th 2025, was 170 million pounds and operating profit was 20 million, up 23% on the year prior, according to its most recent published figures.
The sale of the Rothschild stake, which includes about 20% in voting shares, could value the media company at around 800 million pounds ($1.06 billion), a person familiar with the matter said.
Two top U.S. media executives said a stake in The Economist would give ultra-wealthy people access to even more elite circles.
“Even if you’re at Davos, it’s crowded. But The Economist gets you respect,” one media CEO said. “It will open a lot of interesting doors.”
Reporting by Dawn Kopecki in New York and Amy-Jo Crowley in London. Editing by Anousha Sakoui and Nick Zieminski
Our Standards: The Thomson Reuters Trust Principles., opens new tab
Ford CEO Jim Farley learned from older employees that some young workers at the carmaker were taking shifts at Amazon to make ends meet, he said at the Aspen Ideas Festival. Farley said he drew on founder Henry Ford’s decision to raise factory wages to $5 a day in 1914 to make temporary workers into full-time employees. Young people have previously eschewed manufacturing jobs due to low wages.
Some economists credit carmaker Henry Ford for jump-starting the American middle class in the 20th century when, in January 1914, he hiked factory wages to $5, more than double the average wage for an eight-hour work day.
More than 100 years later, facing the reality of many employees “barely getting by,” Ford CEO Jim Farley said he took a page out of the founder’s playbook.
The carmaker’s chief executive recognized the need to make a change in his workplace when he spoke to veteran employees during union contract negotiations and learned young Ford employees were working multiple jobs and getting inadequate sleep due to low wages, Farley said in an interview with journalist and biographer Walter Isaacson at the Aspen Ideas Festival earlier this year.
“The older workers who’d been at the company said, ‘None of the young people want to work here. Jim, you pay $17 an hour, and they are so stressed,’” Farley said.
Farley learned some workers also held jobs at Amazon, where they worked for eight hours before clocking in to a seven-hour shift at Ford, sleeping for only three or four hours. At a Ford Pro Accelerate event in September, the CEO said entry-level factory workers told him they were working up to three jobs.
As a result, the company made temporary workers into full-time employees, making them eligible for higher wages, profit-sharing checks, and better health care coverage. The transition was outlined in 2019 contract negotiations with the United Auto Workers (UAW), with temporary workers able to become full-time after two years of continuous employment at Ford.
“It wasn’t easy to do,” Farley said. “It was expensive. But I think that’s the kind of changes we need to make in our country.”
Ford’s own decision to double factory wages in 1914 was not altruistic, but rather a strategy to attract a stable workforce, as well as provide a stimulus for his own workers to be able to afford Ford products.
“He said, ‘I’m doing this because I want my factory worker to buy my cars. If they make enough money, they’ll buy my own product,’” Farley said. “It’s a self-fulfilling prophecy, in a way.”
Farley, a proponent of growing U.S. manufacturing productivity to support the essential economy, has advocated for young workers to have strong trade experiences. Earlier this month, he sounded the alarm on the shortage of manual labor jobs, saying in an episode of the Office Hours: Business Edition podcast that Ford had 5,000 open mechanic positions that have remain unfilled, despite an up-to $120,000 salary for the role.
“Our governments have to get really serious about investing in trade schools and skilled trades,” he said at the Aspen Ideas Festival. “You go to Germany, every one of our factory workers has an apprentice starting in junior high school. Every one of those jobs has a person behind it for eight years that is trained.”
Despite the U.S. seeing 3.8 million new manufacturing jobs by 2033, according to Deloitte and the Manufacturing Institute, the younger generation of workers has largely turned away from the career path. As as some ditch college degrees, Gen Z enrollment in trade schools is on the rise, but the newest generation entering the workforce is largely eschewing factory jobs, citing low wages, according to a 2023 Soter Analytics study. U.S. manufacturing jobs in the U.S. have an average $25-per-hour wage—about $51,890 per year—falling short of the average American salary of $66,600.
American carmakers like Ford may be trying to make it appealing for young workers to embark on manufacturing careers, but they are still not immune to workers’ grievances over wages. In 2023, thousands of UAW members, including 16,600 Ford employees, went on strike before reaching a contract deal in October of that year, which, beyond increasing wages, also further decreased the period of time necessary for a temp worker to become full-time.
Farley called the strike “completely unnecessary” from management’s perspective and maintained the onus of improving trade workers’ wages isn’t just on Ford.
“We’re not just going to hope it gets better,” he said. “We have the resources, and we have the know-how, after 120 years, to solve these problems, but we need more help from others.”
A version of this story originally published on Fortune.com on June 30, 2025.
You don’t have permission to access “http://www.spglobal.com/market-intelligence/en/news-insights/research/2025/11/community-banks-margins-expanding-credit-quality-holding-now” on this server.
The Met Police said it had received a referral from Action Fraud following the attack
The Royal Borough of Kensington and Chelsea (RBKC) confirmed that “some data was copied and taken away” during a recent cyber attack.
RBKC said the breach was discovered after detecting unusual activity early on Monday and that it took “all necessary steps” to shut down and isolate systems to make them as secure as possible.
The authority said it believed the breach “only impacts historical data”, adding: “We still have access to this information, it has not been stolen, but it is possible it could end up in the public domain.”
The Met Police said it had received a referral from Action Fraud following the attack. The force said inquiries were in the “early stages” and no arrests had been made.
RBKC said it was checking whether the compromised data included personal or financial details of residents, customers and service users, but warned the process would take time.
The council told the Local Democracy Reporting Service that it took cyber security seriously and spent more than £12m annually on IT and security systems.
With advice from the National Cyber Security Centre (NCSC), RBKC is urging residents, customers and service users to be extra vigilant when receiving calls, emails or text messages.
‘Safeguard our network’
Emergency plans were activated by the council following the attack, and RBKC asked staff to work from home where possible, with some phone lines and online services disrupted.
RBKC has informed the Information Commissioner’s Office.
It is understood that the same incident has also affected Westminster City Council and Hammersmith and Fulham Council due to “joint arrangements”.
Hammersmith and Fulham Council said it “was able to successfully isolate and safeguard our network” and that there was currently “no evidence of H&F systems being compromised”.
However, the council was still investigating its systems and, as a precautionary measure, had temporarily suspended some public-facing applications, it added.
Westminster City Council is due to release a statement shortly.
Additional reporting by Adrian Zorzut, Local Democracy Reporting Service.
Over canapés of beef and stilton pie, bone marrow gravy and mushy peas, the financiers at JP Morgan’s New York headquarters held their champagne flutes aloft for a toast: “His majesty the king”.
Just days before Rachel Reeves’s budget – amid the chancellor’s efforts to soothe business fears and bond market jitters – Jamie Dimon, the Wall Street banking company’s boss was hosting a birthday celebration for King Charles at it’s new $3bn (£2.3bn) Manhattan headquarters.
Despite the union jack emblazoned on the skyscraper, the king was not there. Varun Chandra, the prime minister’s envoy, however, was among the 400 guests. Dispatched, according to the Financial Times, to reassure the JP Morgan boss of Labour’s pro-business stance.
This week – hours after banks were spared a tax rise in Reeves’s £26bn budget – Dimon unveiled plans to build a 279,000 sq metre (3m sq ft) tower in London’s Canary Wharf district, with a caveat that a “continuing positive business environment in the UK” was required.
It is understood that planning issues and long-term considerations are more important for the bank than any one budget. But the episode still highlights how financial services has won a prized status in government, amid ferocious City lobbying to ensure it was one of the few off-limits sectors in Reeves’s smorgasbord tax-raising budget.
For months Labour has been rolling out the red carpet for Wall Street and City financiers, amid a far broader campaign to woo bankers and company bosses after the party’s pre-election love-in with industry turned sour.
Norman Blackwell, the former chair of Lloyds Banking Group, who also advised Margaret Thatcher on policy in the 1980s, said Reeves had “work to do” to rebuild the confidence of the City after her £40bn tax-raising 2024 budget.
“Before the election they talked as though they would be a party that would recognise the importance of wealth creation in the economy by business and entrepreneurs. Everything they have done in government has gone in the opposite direction.
An artist’s impression of the planned JP Morgan Chase building in London’s Canary Wharf. The bank went ahead with the investment after assurances from an adviser to the UK prime minister. Photograph: JP Morgan Chase/PA
“They have increased taxes on business, increased regulation in the labour market, [and] the threat to high earners and non-doms. If you look at the numbers of entrepreneurs and rich people leaving the country – they have convinced people that they do not value and will not support entrepreneurs.”
Despite the reprieve for banks, he said the budget was still unlikely to help much because it would do little to boost UK growth. “It’s a budget that takes the economy in the wrong direction, and is in that sense self-defeating in terms of growth and future government revenue.”
Much of the rationale behind the rearguard action is pragmatic. Reeves sees the City as critical to the government’s growth mission, with financial services among the eight critical sectors backed in Labour’s industrial strategy. Finance contributes almost a tenth of UK GDP, employs 1.2 million people, and brings in more than £40bn a year for the exchequer.
In Birmingham earlier this autumn, the chancellor hosted a gala dinner for 300 financiers and business chiefs – putting on a ballet and a spoken-word poetry reading on the eve of its first regional investment summit. Sponsored by HSBC, Lloyds, Eon, KPMG, and IBM, the event the next day at Edgbaston cricket ground secured more than £10bn of investment in Britain.
However, Labour’s proximity to the boardrooms of the Square Mile does not sit comfortably with the party’s own MPs and voters for whom the memories of the 2008 financial crisis still sting. Most people – including a majority of those considering voting for Nigel Farage’s Reform UK – would have backed a windfall tax on banks at the budget.
“The chancellor’s failure to levy a windfall tax on the banking sector in the budget is a damning indictment of the stronghold the sector continues to have over our politics,” said Sara Hall, a co-executive director at the campaign group Positive Money.
“It is very concerning that whilst the public is asked to contribute more to fix our crumbling public services, banks got off scott free – it’s high time we have a proper public conversation about the sector’s lobbying and influence.”
Reeves hosted Goldman Sachs boss David Solomon in No 11 last month. Photograph: Mike Blake/Reuters
Last month Reeves hosted Goldman Sachs boss David Solomon in No 11 Downing Street, with the head of the Wall Street firm advising her against increasing bank taxes. Politico reported he ripped up his briefing notes to focus exclusively on the issue, a detail denied by the bank.
This week, after the budget, Goldman announced that it would expand its Birmingham office and hire 500 staff, in a move that would more than double its workforce in the UK’s second-largest city.
skip past newsletter promotion
after newsletter promotion
The story could have been different. Reeves had been actively considering a multibillion-pound bank windfall tax to help repair the public finances and fund the removal of the two-child benefit limit.
In August a paper by the Institute for Public Policy Research thinktank estimated Reeves could rake in as much as £8bn, in a report triggering a sell-off in UK banking shares and prompting the industry to lobby harder.
Reeves’s office was furious with the IPPR report suggesting a windfall tax, and subsequent share price reaction. However, insiders said the Treasury had requested to see the report in advance of its publication.
The Guardian also understands bank profits – inflated by the Bank of England’s quantitative easing scheme – were examined by Treasury officials on the instruction of ministers in the buildup to the budget.
“We get whiplash in meetings with HMT at times,” said one senior banker.
“One minute they’re [senior officials] incredibly nervous about inward investment, the next they’re suggesting that major structural problems are businesses’ fault. Narratives like lenders are the real handbrake on growth creep in. I think they’ve come to realise that the City can’t be taken for granted. London’s one of many financial centres for global banks.”
Rachel Reeves had actively considered a multibillion-pound bank windfall tax, but dropped the plan. Photograph: Adrian Dennis/AP
London’s high-paid corporate lawyers were also among those who expressed relief after the budget, after escaping a threatened tax on their earnings. Reports suggested Reeves was looking at scrapping an exemption for limited liability partnership members from national insurance – a move that would have raised £2bn.
Mark Evans, the president of the Law Society, a body representing lawyers, this week welcomed the reprieve, saying it would have been damaging to the UK economy and claiming that law firms would not have been able to invest, hire, and contribute to growth.
Banking industry figures said the sector pays a 28% headline rate of corporation tax, above the standard 25% rate charged on company profits, in addition to a 0.1% levy on bank’s balance sheets. “It’s hard to say we don’t pay a fair share, as we pay more,” said one bank lobbyist.
However, banks have still managed to rake in record profits, benefiting from rising interest rates and the winding down of the Bank’s quantitative easing scheme. In total, Positive Money estimates banks made £24.1bn in the first half of 2025 alone, amounting to almost £1bn a week.
Speaking earlier this autumn, Paul Nowak, the general secretary of the TUC, said getting banks to pay a little more to help rebuild Britain was common sense. “Banks have done very well out of the British people. It’s only right that they use their bumper profits to pay a bit more in tax to invest in our hospitals, schools and local councils.”
The Treasury was approached for comment. JP Morgan declined to comment.
Brugada, P. & Brugada, J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome. A multicenter report. J. Am. Coll. Cardiol.20, 1391–1396 (1992).
Google Scholar
Monasky, M. M. et al. Genotype-phenotype correlation in a family with Brugada syndrome harboring the novel p.Gln371* nonsense variant in the SCN5A gene. Int. J. Mol. Sci.20, 5522 (2019).
Google Scholar
Milman, A. et al. Profile of patients with Brugada syndrome presenting with their first documented arrhythmic event: data from the Survey on Arrhythmic Events in BRUgada Syndrome (SABRUS). Heart Rhythm15, 716–724 (2018).
Google Scholar
Rimmerman, N. et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol. Pharm.74, 213–224 (2008).
Google Scholar
Bradshaw, H. B., Raboune, S. & Hollis, J. L. Opportunistic activation of TRP receptors by endogenous lipids: exploiting lipidomics to understand TRP receptor cellular communication. Life Sci.92, 404–409 (2013).
Google Scholar
Amarouch, M. Y. & El Hilaly, J. Inherited Cardiac Arrhythmia Syndromes: focus on molecular mechanisms underlying TRPM4 channelopathies. Cardiovasc. Ther.2020, 6615038 (2020).
Google Scholar
Alom, F. et al. Possible antagonistic effects of the TRPC4 channel blocker ML204 on M(2) and M(3) muscarinic receptors in mouse ileal and detrusor smooth muscles and atrial myocardium. J. Vet. Med Sci.80, 1407–1415 (2018).
Google Scholar
Szentandrássy, N. et al. Effects of rosiglitazone on the configuration of action potentials and ion currents in canine ventricular cells. Br. J. Pharmacol.163, 499–509 (2011).
Google Scholar
Pieroni, M. et al. Electroanatomic and pathologic right ventricular outflow tract abnormalities in patients with Brugada Syndrome. J. Am. Coll. Cardiol.72, 2747–2757 (2018).
Google Scholar
Bonny, A. et al. C-reactive protein levels in the Brugada syndrome. Cardiol. Res Pract.2011, 341521 (2011).
Google Scholar
Li, A., Tung, R., Shivkumar, K. & Bradfield, J. S. Brugada syndrome-Malignant phenotype associated with acute cardiac inflammation? HeartRhythm Case Rep.3, 384–388 (2017).
Google Scholar
Gijsbers, K. et al. GCP-2/CXCL6 synergizes with other endothelial cell-derived chemokines in neutrophil mobilization and is associated with angiogenesis in gastrointestinal tumors. Exp. Cell Res.303, 331–342 (2005).
Google Scholar
Torán, J. L. et al. CXCL6 is an important paracrine factor in the pro-angiogenic human cardiac progenitor-like cell secretome. Sci. Rep.7, 12490 (2017).
Google Scholar
Bahudhanapati, H. et al. Increased expression of CXCL6 in secretory cells drives fibroblast collagen synthesis and is associated with increased mortality in idiopathic pulmonary fibrosis. Eur. Respir. J.63, 2300088 (2024).
Google Scholar
Shandelya, S. M., Kuppusamy, P., Herskowitz, A., Weisfeldt, M. L. & Zweier, J. L. Soluble complement receptor type 1 inhibits the complement pathway and prevents contractile failure in the postischemic heart. Evidence that complement activation is required for neutrophil-mediated reperfusion injury. Circulation88, 2812–2826 (1993).
Google Scholar
Lazar, H. L. et al. Beneficial effects of complement inhibition with soluble complement receptor 1 (TP10) during cardiac surgery. Circulation116, I-83–I-88 (2007).
Google Scholar
Milman, A. et al. Gender differences in patients with Brugada syndrome and arrhythmic events: data from a survey on arrhythmic events in 678 patients. Heart Rhythm15, 1457–1465 (2018).
Google Scholar
Li, Q., Wang, P., Ye, K. & Cai, H. Central role of SIAH inhibition in DCC-dependent cardioprotection provoked by netrin-1/NO. Proc. Natl. Acad. Sci. USA112, 899–904 (2015).
Google Scholar
Juang, J.-M. J. et al. Validation and disease risk assessment of previously reported genome-wide genetic variants associated with Brugada Syndrome. Circ. Genom. Precis. Med.13, e002797 (2020).
Google Scholar
Van Hemelrijck, M., Shanmugalingam, T., Bosco, C., Wulaningsih, W. & Rohrmann, S. The association between circulating IGF1, IGFBP3, and calcium: results from NHANES III. Endocr. Connect.4, 187–195 (2015).
Google Scholar
Ezzili, C., Otrubova, K. & Boger, D. L. Fatty acid amide signaling molecules. Bioorg. Med. Chem. Lett.20, 5959–5968 (2010).
Google Scholar
Riccio, A. et al. mRNA distribution analysis of human TRPC family in CNS and peripheral tissues. Brain Res. Mol. Brain Res.109, 95–104 (2002).
Google Scholar
Bröker-Lai, J. et al. Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory. EMBO J.36, 2770–2789 (2017).
Google Scholar
Du, S. L., Jia, Z. Q., Zhong, J. C. & Wang, L. F. TRPC5 in cardiovascular diseases. Rev. Cardiovasc. Med.22, 127–135 (2021).
Google Scholar
Liu, T., Zhao, H., Li, J., Korantzopoulos, P. & Li, G. Rosiglitazone attenuates atrial structural remodeling and atrial fibrillation promotion in alloxan-induced diabetic rabbits. Cardiovasc. Ther.32, 178–183 (2014).
Google Scholar
Launay, P. et al. TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization. Cell109, 397–407 (2002).
Google Scholar
Nilius, B. et al. Voltage dependence of the Ca2+-activated cation channel TRPM4. J. Biol. Chem.278, 30813–30820 (2003).
Google Scholar
Tarifa, C. et al. Spatial distribution of calcium sparks determines their ability to induce afterdepolarizations in human atrial myocytes. JACC Basic Transl. Sci.8, 1–15 (2023).
Google Scholar
Clapham, D. E. TRP channels as cellular sensors. Nature426, 517–524 (2003).
Google Scholar
Vutthikraivit, W. et al. Worldwide prevalence of Brugada Syndrome: a systematic review and meta-analysis. Acta Cardiol. Sin.34, 267–277 (2018).
Google Scholar
Barc, J. et al. Genome-wide association analyses identify new Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility. Nat. Genet.54, 232–239 (2022).
Google Scholar
Priori, S. G. et al. Executive summary: HRS/EHRA/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes. Europace15, 1389–1406 (2013).
Google Scholar
Priori, S. G. et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur. Heart J.36, 2793–2867 (2015).
Google Scholar
Al-Khatib, S. M. et al. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: Executive Summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. Circulation138, e210–e271 (2018).
Google Scholar
Verweij, N. et al. The genetic makeup of the electrocardiogram. Cell Syst.11, 229–238.e225 (2020).
Google Scholar
Nauffal, V. et al. Monogenic and polygenic contributions to QTc prolongation in the population. Circulation145, 1524–1533 (2022).
Google Scholar
Ferkingstad, E. et al. Large-scale integration of the plasma proteome with genetics and disease. Nat. Genet.53, 1712–1721 (2021).
Google Scholar
Sun, B. B. et al. Plasma proteomic associations with genetics and health in the UK Biobank. Nature622, 329–338 (2023).
Google Scholar
Võsa, U. et al. Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression. Nat. Genet.53, 1300–1310 (2021).
Google Scholar
Chen, Y. et al. Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases. Nat. Genet.55, 44–53 (2023).
Google Scholar
Willer, C. J. et al. Discovery and refinement of loci associated with lipid levels. Nat. Genet.45, 1274–1283 (2013).
Google Scholar
Barton, A. R., Sherman, M. A., Mukamel, R. E. & Loh, P.-R. Whole-exome imputation within UK Biobank powers rare coding variant association and fine-mapping analyses. Nat. Genet.53, 1260–1269 (2021).
Google Scholar
Evangelou, E. et al. Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nat. Genet.50, 1412–1425 (2018).
Google Scholar
Chen, J. et al. The trans-ancestral genomic architecture of glycemic traits. Nat. Genet.53, 840–860 (2021).
Google Scholar
Soranzo, N. et al. Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways. Diabetes59, 3229–3239 (2010).
Google Scholar
Yengo, L. et al. Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry. Hum. Mol. Genet.27, 3641–3649 (2018).
Google Scholar
Malik, R. et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nat. Genet.50, 524–537 (2018).
Google Scholar
Nikpay, M. et al. A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat. Genet.47, 1121–1130 (2015).
Google Scholar
Shah, S. et al. Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure. Nat. Commun.11, 163 (2020).
Google Scholar
Kurki, M. I. et al. FinnGen provides genetic insights from a well-phenotyped isolated population. Nature613, 508–518 (2023).
Google Scholar
Pattaro, C. et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat. Commun.7, 10023 (2016).
Google Scholar
Forgetta, V. et al. Rare genetic variants of large effect influence risk of type 1 diabetes. Diabetes69, 784–795 (2020).
Google Scholar
Xue, A. et al. Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. Nat. Commun.9, 2941 (2018).
Google Scholar
Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet.81, 559–575 (2007).
Google Scholar
Hemani, G., Tilling, K. & Davey Smith, G. Orienting the causal relationship between imprecisely measured traits using GWAS summary data. PLoS Genet.13, e1007081 (2017).
Google Scholar
Skrivankova, V. W. et al. Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR Statement. JAMA326, 1614–1621 (2021).
Google Scholar
Giambartolomei, C. et al. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet.10, e1004383 (2014).
Google Scholar
Tofighi, D. & MacKinnon, D. P. RMediation: an R package for mediation analysis confidence intervals. Behav. Res. Methods43, 692–700 (2011).
Google Scholar
Du, L. et al. Dockey: a modern integrated tool for large-scale molecular docking and virtual screening. Brief. Bioinform.24, bbad047 (2023).
Google Scholar
Zhang, Q. et al. Increase in CO(2) levels by upregulating late sodium current is proarrhythmic in the heart. Heart Rhythm16, 1098–1106 (2019).
Google Scholar
Tomek, J., Nieves-Cintron, M., Navedo, M. F., Ko, C. Y. & Bers, D. M. SparkMaster 2: a new software for automatic analysis of calcium spark data. Circ. Res133, 450–462 (2023).
Google Scholar
Tomek, J. et al. Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block. eLife8, e48890 (2019).
Google Scholar
Xu, H. Code for “N-palmitoyl glycine differentially modulates TRPM4 and TRPC5 and is causally linked to Brugada syndrome”. Zenodo, https://doi.org/10.5281/zenodo.17536545 (2025).
Getty Images
