Category: 3. Business

  • Asian Stocks Set Record as Tech Rally Powers On: Markets Wrap

    Asian Stocks Set Record as Tech Rally Powers On: Markets Wrap

    (Bloomberg) — Asia’s tech-led rally pushed to new highs after strong earnings from a chip bellwether eased worries about overheating in the artificial intelligence sector and encouraged investors to add bets.

    The MSCI Asia Pacific Index climbed 0.4% on Friday to a record and was set for a fourth weekly gain. A regional gauge of technology shares and South Korea’s benchmark index — a poster-child for the AI theme — also hit all-time highs as Taiwan Semiconductor Manufacturing Co. rose to its highest ever after blowout results.

    TSMC’s earnings rekindled enthusiasm for stocks, helping US equities rebound from their first back-to-back losses of the year. That optimism looked set to continue with futures for the S&P 500 and the Nasdaq 100 rising 0.2%. Elsewhere, the yen gained against the dollar after Japan’s finance minister said she’s concerned about the currency’s weakness. Oil steadied after its biggest decline since June, while gold and silver edged lower.

    Stocks are extending gains as investors regain confidence in the durability of the tech rally, a key bull-market driver, after concerns over stretched valuations and heavy investment. Comments from TSMC also helped ease worries about the sustainability of data-center spending following a recent pullback in richly valued technology shares.

    “Technology stocks had looked vulnerable in recent weeks as investors rotated away from megacap names and into more cyclical areas of the market,” said Fawad Razaqzada at Forex.com. “TSMC’s update, though, appears to have stabilized that ‘rotation’ rather than reversed it outright.”

    As Asian shares keep rising, a key relationship they have with currencies is flashing a signal for global funds to rethink their investment strategy in the region.

    The 30-day correlation between the MSCI Asia Pacific Index and the Bloomberg Asia Dollar Index — which typically move in lockstep — has dipped below zero for the first time since September 2024.

    In other corners of the market, Treasuries were little changed in Asia after falling in US trading when jobless claims unexpectedly dropped to the lowest since November.

    The 10-year’s yield is headed for a fifth straight week of minimal change, rivaling its longest stretch of inertia in the past two decades.

    The trend — a function primarily of expected stability in US monetary policy — is stoking anxiety among bond-market investors because previous instances of constricted yield ranges have been followed by selloffs.

    Traders will also be watching the rising tensions in the Middle East after Fox News reported that at least one US aircraft carrier is moving to the region. US military planners are preparing a range of options depending on the actions of the Iranian government in the next few days, Fox reported.

    Separately, the US and Taiwan agreed to a long-sought trade pact that would lower tariffs on goods from the self-governed island to 15% and see Taiwanese semiconductor companies increase financing for American operations by $500 billion.

    In Asia, focus is also on Japan, where central bank officials are closely watching the yen’s potential influence on inflation.

    Most Bank of Japan watchers judge that Governor Kazuo Ueda and his colleagues have been slow in ratcheting up interest rates, and expect the next move still to be several months away in their base case scenarios.

    Traders are also parsing capital flows in and out of Japan Friday as the yen inches toward the 160-per-dollar mark.

    Official intervention to strengthen the currency is a topic of discussion among market participants as the yen trades near a one-and-a-half-year low. The yen was a touch stronger at 158.40 against the dollar on Friday.

    “We have obviously previously seen Japan intervene above the 160 level and as we get closer to that, I think that becomes a possibility,” said Divya Devesh, co-head of FX research for Asean and South Asia at Standard Chartered. “It is an unstable equilibrium,” he said of Japan’s macro backdrop.

    Corporate Highlights:

    Goldman Sachs is set to raise $16 billion with the largest investment-grade bond sale ever from a Wall Street bank. China Vanke Co.’s bonds extended their rally, a day after the distressed developer unveiled sweetened proposals to extend payments on some notes. Ford Motor Co. is in talks with China’s BYD Co. about potentially supplying batteries for hybrid vehicles to the American automaker’s overseas factories. Walmart Inc. said Kathryn McLay, chief executive officer of the company’s international business, is stepping down. Some of the main moves in markets:

    Stocks

    S&P 500 futures rose 0.2% as of 11:53 a.m. Tokyo time Japan’s Topix fell 0.3% Australia’s S&P/ASX 200 rose 0.5% Hong Kong’s Hang Seng fell 0.1% The Shanghai Composite fell 0.1% Euro Stoxx 50 futures fell 0.3% Currencies

    The Bloomberg Dollar Spot Index was little changed The euro was little changed at $1.1611 The Japanese yen rose 0.2% to 158.29 per dollar The offshore yuan was little changed at 6.9641 per dollar Cryptocurrencies

    Bitcoin was little changed at $95,484.42 Ether was little changed at $3,300.03 Bonds

    The yield on 10-year Treasuries was little changed at 4.16% Japan’s 10-year yield advanced 1.5 basis points to 2.175% Australia’s 10-year yield advanced two basis points to 4.70% Commodities

    West Texas Intermediate crude fell 0.2% to $59.10 a barrel Spot gold fell 0.4% to $4,595.41 an ounce This story was produced with the assistance of Bloomberg Automation.

    –With assistance from Ruth Carson.

    ©2026 Bloomberg L.P.

    Continue Reading

  • Construction begins on Fortescue’s first wind project in the Pilbara

    15 January 2026

    Fortescue has commenced construction of its Nullagine Wind Project in the Pilbara, marking a major milestone in the Company’s plan to reach its Real Zero target.

    Fortescue has commenced construction of its Nullagine Wind Project in the Pilbara, marking a major milestone in the Company’s plan to reach its Real Zero target.

    The project is Fortescue’s first operational wind development and establishes the foundation for a broader portfolio of wind capacity to be rolled out this decade.

    The Nullagine Wind Project builds on strong momentum across Fortescue’s Pilbara renewable energy program, with construction of the Cloudbreak Solar Farm now powering towards completion with over 300,000 solar panels installed.

    The 133MW project will see 17 wind turbines installed, incorporating Nabrawind’s self-erecting tower technology following Fortescue’s recent acquisition of the Company. Supplied by Envision Energy, a global green technology leader and Fortescue partner, the turbines are designed for low-wind environments and engineered to withstand extreme weather, including cyclones.

    Envision will subcontract Nabrawind to integrate its Nabralift self-erecting tower system, delivering a hub height of 188 metres – setting a new global benchmark for onshore wind and unlocking significantly higher energy yield.

    A Nabrawind-integrated turbine of this design has already been installed as a prototype at an Envision testing facility in China and will be relocated to the Pilbara in June 2026.

    Fortescue Metals and Operations Chief Executive Officer Dino Otranto said: “Delivering Real Zero requires replacing diesel and gas with reliable, industrial-scale renewable energy.

    “Wind – alongside solar and batteries – provides the dependable, low-cost power we need to electrify our haul trucks, drills, processing plants and rail across the Pilbara.

    “The Nullagine Wind Project will feed directly into Pilbara Energy Connect, strengthening supply by balancing daytime solar with strong night-time and seasonal wind generation.

    “With Cloudbreak solar well advanced and large-scale batteries already delivered at North Star Junction, this is a baseload renewable energy system that’s being built, tested and delivered in real operating conditions.”

    By 2030, Fortescue plans to deploy 2-3GW of renewable energy generation and battery storage, including a portfolio of wind and solar projects across the Pilbara, subject to land access and regulatory approvals.

    Future projects will be announced as they reach Final Investment Decision. 

    Continue Reading

  • Flying cars are soaring from pages of science fiction to reality | Driving Into the Future

    Flying cars are soaring from pages of science fiction to reality | Driving Into the Future

    Flying cars are no longer a science fiction fantasy, but are becoming a reality.

    They are currently in production and could be delivered to customers within the next year or two.

    The company is called Alef Aeronautics.

    Founded in 2015, it is at the forefront of the flying car industry, with more than 3,500 pre-orders of its flying cars.

    The Alef Model A Ultralight is a vehicle that can drive and fly, as seen in a testing video where the vehicle elevates and goes airborne over another car.

    The video has over 2 billion views worldwide.

    “A little under a month ago, we started building the first car to be delivered to the actual customer,” said Jim Dukhovny.

    Alef Aeronautics co-founder Jim Dukhovny said his company and technology have two priorities: safety and regulatory compliance.

    Dukhovny said this vehicle will be able to elevate thousands of feet or just 20.

    “At this point at least, the cabin is not pressurized. So you can’t go up to the levels where you need a pressurized cabin,” he said.

    Dukhovny said the current Model A ultralight goes for $300,000.

    But he expects in about a decade, the price will drop to roughly $30,000.

    He called it an EV car first, an aircraft second, with a range of 200 miles on the road and 110 in the air.

    It will fall under existing ultra light aircraft Federal Aviation Administration regulations, which means no certification is required currently.

    “There are rules where you can take off and land. So if you’re imagining a scenario that you’re going to drive on the freeway, take off, fly, and then land on the freeway, that’s not going to happen,” he said.

    He said learning to operate the vehicle will only take a few hours, but also require to learn FAA regulations.

    “So you have to read the sectional map, you have to understand the alpha, bravao airspace and where you can fly, where you cannot fly,” he added.

    The first models are expected to hit the roadways in either Silicon Valley or Hong Kong and will test real world conditions under very controlled testing.

    Copyright © 2026 WPVI-TV. All Rights Reserved.

    Continue Reading

  • US to cut tariffs on Taiwanese goods after investment pledge

    US to cut tariffs on Taiwanese goods after investment pledge

    Natalie Sherman,Business reporterand

    Lily Jamali,North America Technology correspondent

    Bloomberg via Getty Images Employees wearing cleanroom suits walk beneath Automated Material Handling Systems (AMHS) vehicle robots moving along tracks on the ceiling inside the GlobalFoundries semiconductor manufacturing facility in Malta, New York, U.S., on Tuesday, March 16, 2021. Bloomberg via Getty Images

    The US has been pushing to build up its semiconductor industry

    The US said it had agreed to cut the tariffs it charges on goods from Taiwan to 15%, in exchange for hundreds of billions of dollars in investment aimed at boosting domestic production of semiconductors.

    The Commerce Department said the island’s semiconductor and technology enterprises had committed to “new, direct investments” worth at least $250bn (£187bn).

    The deal also provides carve-outs from tariffs for Taiwanese semiconductor companies investing in the US.

    Boosting US production of semiconductor chips, which are found in machines ranging from cars to smart phones, has been a priority for the US since shortages during the Covid-19 pandemic exposed supply chain risks.

    In an interview on CNBC, Commerce Secretary Howard Lutnick said the agreement would help the US become “self-sufficient”.

    “We’re going to bring it all over,” he said.

    The US has devoted hundreds of billions of dollars in government subsidies to the semiconductor industry in recent years, helping to secure and expand investments from the likes of TSMC, the Taiwanese manufacturing giant that dominates the industry.

    As part of its earnings update on Thursday, the company said it was accelerating its investments in the US, where it opened a plant in 2024.

    The factory in Arizona, which now makes chips for Nvidia, Apple, AMD and other major American tech companies, was built with the help of $40bn in US government subsidies passed during the Biden administration.

    Lutnick said the latest trade deal could lead the firm to expand and was also meant to further develop the supply chain, convincing smaller businesses to relocate to the US as well.

    As well as the direct investments from companies, the Taiwanese government will provide $250bn in financing to support firms, according to the Commerce Department.

    Taiwan, a self-governed island claimed by China, had been pushing to reach an agreement with the Trump administration over the duties faced by its exports entering the US, set at 20% last year.

    But it has been wary of demands to transfer its expertise, seen by some as a safeguard against military action.

    The new 15% tariff rate matches the rates the US currently charges on goods from key trade partners such as Japan, South Korea, and the European Union.

    Those rates were agreed in deals stemming from tariffs Trump first announced last April, which he said were aimed at addressing imbalances in trade.

    The Supreme Court is currently weighing a request from businesses and states in the US to strike down those duties, which they claim were imposed in an overreach of presidential power.

    The Trump administration had previously threatened separate, wider tariffs on the semiconductor industry in the name of national security.

    It has so far held off on that proposal, which met with widespread alarm by US firms dependent on imports, including from some firms in the sector.

    The announcement comes as American chip manufacturer Intel, a TSMC rival, has struggled to gain traction making advanced chips designed for artificial intelligence.

    In a surprise move last year, the US government took a 10% stake in Intel but the company is due to cut thousands more American positions in addition to those it has already slashed in recent years.

    Overall, the semiconductor manufacturing sector shed more than 17,000 jobs last year, according to the latest data, despite government efforts to boost the industry.

    Continue Reading

  • Nabors Announces Redemption of 7.500% Senior Guaranteed Notes Due 2028 and Fourth Quarter 2025 Reduction in Net Debt of Approximately $366 Million, Equivalent to $25 per Share

    Nabors Announces Redemption of 7.500% Senior Guaranteed Notes Due 2028 and Fourth Quarter 2025 Reduction in Net Debt of Approximately $366 Million, Equivalent to $25 per Share

    HAMILTON, Bermuda, Jan. 15, 2026 /PRNewswire/ — Nabors Industries Ltd. (“Nabors” or the “Company”) (NYSE: NBR) today announced the full redemption of its outstanding 7.500% Senior Guaranteed Notes due 2028, with a face value of approximately $379 million. The Notes were redeemed at par, plus accrued and unpaid interest, on January 15, 2026.

    Nabors also announced certain preliminary balance sheet figures. As of December 31, 2025, total debt amounted to approximately $2.5 billion. Cash and short-term investments were approximately $940 million. Net debt, defined as total debt less cash and short-term investments, was approximately $1.55 billion as of December 31, 2025, bringing net leverage to its lowest level since 2008. This amount represents a reduction of approximately $366 million – equivalent to approximately $25 per Nabors common share – during the fourth quarter and approximately $550 million since December 31, 2024.  

    Following the redemption, long–term debt stands at approximately $2.15 billion. The Company’s next debt maturity occurs in 2029. Also following the redemption, the weighted average maturity on Nabors’ outstanding debt has increased to 5.3 years, from 3.7 years as of September 30, 2025.

    Anthony G. Petrello, Nabors Chairman, President and CEO, commented, “This redemption represents another meaningful step in advancing our commitment to debt reduction as a core driver of shareholder value. The combination of our opportunistic Parker Wellbore and Quail Tools transactions, together with strong operational execution, contributed to this outcome. We have successfully cleared and extended our financing runway to 2029. These actions materially strengthen our capital structure and position the Company for continued strategic progress.”

    About Nabors Industries

    Nabors Industries (NYSE: NBR) is a leading provider of advanced technology for the energy industry. With presence in more than 20 countries, Nabors has established a global network of people, technology and equipment to deploy solutions that deliver safe, efficient and responsible energy production. By leveraging its core competencies, particularly in drilling, engineering, automation, data science and manufacturing, Nabors aims to innovate the future of energy and enable the transition to a lower-carbon world. Learn more about Nabors and its energy technology leadership: www.nabors.com.

    Forward-looking Statements

    The information included in this press release includes forward-looking statements within the meaning of the Securities Act of 1933 and the Securities Exchange Act of 1934. Such forward-looking statements are subject to a number of risks and uncertainties, as disclosed by Nabors from time to time in its filings with the Securities and Exchange Commission. As a result of these factors, Nabors’ actual results may differ materially from those indicated or implied by such forward-looking statements. The forward-looking statements contained in this press release reflect management’s estimates and beliefs as of the date of this press release. Nabors does not undertake to update these forward-looking statements. 

    Non-GAAP Disclaimer

    This press release presents a “non-GAAP” financial measure. The components of this non-GAAP measure are computed by using amounts that are determined in accordance with accounting principles generally accepted in the United States of America (“GAAP”). Net debt is calculated as total debt minus the sum of cash, cash equivalents and short-term investments.

    This non-GAAP measure has limitations and therefore should not be used in isolation or as a substitute for the amounts reported in accordance with GAAP. However, management evaluates the performance of its operating segments and the consolidated Company based on several criteria, including net debt, because it believes that this financial measure accurately reflects the Company’s liquidity. Securities analysts and investors also use this measure as one of the metrics on which they analyze the Company’s performance. Other companies in this industry may compute this measure differently. A reconciliation of net debt to total debt, which is the nearest comparable GAAP financial measure, is included in the table at the end of this press release.

    Investor Contacts:  William C. Conroy, CFA, Vice President of Corporate Development & Investor Relations, +1 281-775-2423 or via e-mail [email protected], or Kara K. Peak, Director of Corporate Development & Investor Relations, +1 281-775-4954 or via email [email protected]. To request investor materials, contact Nabors’ corporate headquarters in Hamilton, Bermuda at +441-292-1510 or via e-mail [email protected]

    SOURCE Nabors Industries Ltd.

    Continue Reading

  • Casca Named Banking and Financial Services Winner in the 2026 BIG Innovation Awards

    Casca Named Banking and Financial Services Winner in the 2026 BIG Innovation Awards

    CEO and co-founder, Lukas Haffer, was recognized in the Banking and Financial Services category for Innovative Individuals

    SAN FRANCISCO, Jan. 15, 2026 /PRNewswire/ — Casca, the first AI-native loan origination platform, is proud to announce that it has been named a Banking and Financial Services Winner in the 2026 BIG Innovation Awards, a global recognition program honoring companies, products, and leaders who are transforming industries through applied innovation, intelligent platforms, and measurable real-world impact.

    “The 2026 BIG Innovation Awards winners show that true innovation is no longer about chasing the latest buzzwords,” said Russ Fordyce, Chief Recognition Officer at the Business Intelligence Group. “It’s about building intelligent platforms, automating workflows with purpose, and making trust, privacy, and resilience the foundation of every breakthrough. These organizations and leaders are not just keeping pace with change, they are shaping the future of global business.”

    Casca was recognized for its outstanding contributions to innovation in banking and financial services. Rather than incrementally improving legacy systems, the company rebuilt one of banking’s slowest and most complex processes from the ground up. Its AI-native loan origination platform replaces outdated lending infrastructure with responsible, automated workflows designed to meet bank-grade underwriting and compliance standards. As a result, community banks and credit unions using Casca are funding small business loans up to 30x faster than industry averages, with end-to-end processing times as short as one to four days.

    “We are honored to receive this recognition, “Casca co-Founder and CEO Lukas Haffer said “This award reflects a belief we’ve held from day one: that responsible, well-designed technology can fundamentally improve access to capital for small businesses while strengthening the role of banks as trusted financial partners. Innovation, to us, means building systems that work in the real world and make a meaningful difference for the people who rely on them.”

    In addition, Lukas Haffer was recognized in the Banking and Financial Services category for Innovative Individuals. Under his leadership, Casca has grown from an early-stage concept into one of the most impactful AI innovations in small business lending. In 2025, Casca raised a $29 million Series A. Casca’s flagship customers – Live Oak Bank, the nation’s leading U.S. Small Business Administration SBA 7(a) lender by dollar volume, Huntington National Bank, the nation’s largest originator, by volume of SBA 7(a) loans, and Bankwell Bank, Casca’s first customer – all invested. 

    Casca joins 159 winners recognized for their contributions to innovation across health, financial services, logistics, manufacturing, and enterprise technology. The 2026 BIG Innovation Awards winners reveal a clear trend: innovation is no longer about just having AI, it’s about how you use it. Winners are building platforms, automating workflows, and focusing on trust, privacy, and security as core to their mission.

    For more information about the BIG Innovation Awards and to view the full list of winners, visit www.bintelligence.com/posts/2026-big-innovation-awards-159-trailblazers-prove-where-innovation-is-really-happening.

    About Casca
    Casca accelerates the loan application and origination process using responsible AI. It is the loan origination platform used by the nation’s leading SBA lenders and FDIC-Insured banks. Founded in 2023 by banking IT experts and AI researchers from Stanford University, Casca is backed by Y Combinator, Canapi Ventures, Peterson Ventures, Clocktower Ventures, The Fintech Fund, and the Sarah Smith Fund. For more information, visit www.cascading.ai and follow us on LinkedIn.

    About Business Intelligence Group
    The Business Intelligence Group was founded with the mission of recognizing true talent and superior performance in business. Unlike many recognition programs, these awards are evaluated by business leaders and practitioners who reward programs, products, and people that deliver real, quantifiable excellence rather than marketing narratives.

    SOURCE Cascading AI

    Continue Reading

  • Bosch Rexroth factory workers accept pay deal after strike action

    Bosch Rexroth factory workers accept pay deal after strike action

    Google The grey building has lots dark glass windows. It has a flat roof and an empty car park in the foreground with grass and a tree.Google

    Workers at Bosch Rexroth went on strike in December

    A dispute over jobs, pay and conditions at a hydraulic equipment factory in Glenrothes has been resolved after workers accepted a 4% increase, according the Unite union.

    More than 280 Bosch Rexroth workers have taken the deal, which also includes removing proposed redundancies and plans to change working practices, Unite said.

    It comes after a week of strike action by staff in December, with more workouts planned for Monday.

    The firm’s management said they were pleased the offer had been accepted and that agreed changes would help give the site a sustainable future.

    Unite industrial officer George Ramsay said the employer had “finally listened to its skilled and dedicated workers by removing the threat to slash pay and job security”.

    “The conciliation service Acas also played a valuable role in the resolution of the dispute which must be acknowledged,” he added.

    He said the deal had been secured because of the “determination of our members to stand firm.”

    A spokesman for the Bosch Rexroth Glenrothes management team said: “We are grateful for the positive engagement from employees and their representatives, and we firmly believe that these changes will help to achieve the sustainable future that benefits everyone at the Glenrothes plant.”

    What was the dispute over?

    The union claimed that plans to impose short-time working – when hours are cut if there is not enough work – could see staff lose up to 40% of their take-home pay, equivalent to £1,000 per month.

    It also said the German-owned firm proposed to impose an annualised hours system which “could put workers up to 70 hours in debt.”

    Unite said that, under this system, if a worker is paid for more hours than they have worked, an employer can recover the overpayment on a debt basis.

    Bosch Rexroth had said the proposals aimed to maintain full employment at the Glenrothes site while facing disruptive market conditions.

    He added: “We firmly believe the new proposals are essential to provide the necessary flexibility to respond to market fluctuations.”

    Continue Reading

  • FDA Grants Orphan Drug Designation to Gotistobart in Squamous NSCLC

    FDA Grants Orphan Drug Designation to Gotistobart in Squamous NSCLC

    Squamous NSCLC represents roughly 25–30% of lung cancer cases and, unlike adenocarcinoma, has fewer actionable driver alterations. After progression on frontline chemo-immunotherapy, many patients fall back on single-agent docetaxel, which offers modest benefit and meaningful toxicity—creating a clear unmet need for more effective second-line strategies.

    Non-Small Cell Lung Cancer: Causes, Symptoms, Diagnosis, Treatment Options, and Latest 2025 Advances in Targeted and Immunotherapy

    What Is Gotistobart (BNT316/ONC-392)?

    Gotistobart, also known by its research codes BNT316 or ONC-392, is a next-generation anti–CTLA-4 monoclonal antibody jointly developed by BioNTech SE and OncoC4 in late-stage clinical development across several solid tumor indications, including squamous non–small cell lung cancer (NSCLC) and others.

    Unlike traditional CTLA-4 inhibitors, gotistobart is engineered to be pH-sensitive and to preserve CTLA-4 recycling. When it binds the CTLA-4 receptor on T cells, the antibody-receptor complex is internalized, but under acidic conditions found inside cells, the antibody dissociates rather than triggering lysosomal degradation of CTLA-4. This allows CTLA-4 to return to the cell surface and preserves its function outside the tumor microenvironment, while preferentially depleting immunosuppressive regulatory T cells (Tregs) within the tumor. This tumor-microenvironment-selective action is intended to enhance anti-tumor immunity while potentially limiting peripheral toxicity relative to conventional CTLA-4 blockade.

    Gotistobart is being studied both as monotherapy and in combination with other immunotherapies, and has received regulatory designations—including FDA Fast Track and Orphan Drug status—reflecting its potential in hard-to-treat cancers such as squamous NSCLC.

    Why Orphan Drug Designation matters

    ODD is intended to accelerate development for therapies targeting rare/high-need populations, providing incentives such as tax credits for qualified clinical testing and (if approved) 7 years of marketing exclusivity in the U.S.

    Study Design and Methods

    The ODD announcement is supported by efficacy signals from the ongoing PRESERVE-003 trial (NCT05671510), a global, randomized phase 3 study evaluating gotistobart versus standard chemotherapy in metastatic squamous NSCLC after progression on anti–PD-(L)1 therapy.

    Results

    Phase 3 PRESERVE-003 (dose-confirmation stage; nonpivotal)
    At a median follow-up of 14.5 months, gotistobart monotherapy showed a notable overall survival advantage versus docetaxel:

    • Median OS: not reached (gotistobart) vs 10.0 months (docetaxel)
    • 12-month OS: 63.1% vs 30.3%
    • Risk of death: HR 0.46 (95% CI, 0.25–0.84), P = .0102

    Safety

    In the same dataset, treatment-related toxicity appeared comparable or slightly lower than chemotherapy:

    • Grade ≥3 treatment-related AEs: 42.2% (gotistobart) vs 48.8% (docetaxel)

    Insights

    • If these OS findings hold in the pivotal stage, gotistobart could redefine expectations for post–PD-(L)1, second-line squamous NSCLC, where meaningful OS gains have been difficult to achieve with immunotherapy alone.
    • The therapeutic-index engineering (CTLA-4 recycling concept) is the key scientific bet: maintaining anti-tumor CTLA-4 biology while improving tolerability may be what allows CTLA-4 blockade to succeed as monotherapy in a heavily pretreated population.

    Key Takeaway Messages

    • FDA ODD has been granted to gotistobart for squamous NSCLC.
    • In PRESERVE-003 (dose-confirmation stage), gotistobart showed strong OS separation vs docetaxel (HR 0.46; 12-month OS 63.1% vs 30.3%).
    • Safety appears manageable and at least comparable to chemotherapy in the reported dataset.
    • The program’s differentiator is a pH-sensitive CTLA-4 approach designed around recycling and tumor-selective Treg depletion.

    You Can Watch More on OncoDaily Youtube TV

     

    Continue Reading

  • Stock market today: Live updates

    Stock market today: Live updates

    Traders work on the floor of the New York Stock Exchange (NYSE) in New York City.

    Spencer Platt | Getty Images

    Stocks climbed Thursday, rebounding from back-to-back losses as chip and banks stocks rallied.

    The Dow Jones Industrial Average added 401 points, or 0.8%, boosted by gains in Goldman Sachs and Nvidia. The S&P 500 jumped 0.6%, while the Nasdaq Composite advanced 0.9%.

    Chip plays led the market after Taiwan Semiconductor delivered another record quarter, saying it expects to boost capital spending in 2026 to between $52 billion and $56 billion — an outlook signaling confidence in the artificial intelligence buildout from the world’s largest contract chipmaker. The stock jumped more than 6%. The VanEck Semiconductor ETF (SMH) climbed 3%, with Nvidia and Micron Technology adding more than 2% each.

    “Taiwan Semi’s results today, and more importantly, their capex spending plans point to reassuring investors that the AI trade is not necessarily a bubble at this point,” said Kim Forrest, investment chief at Bokeh Capital Partners. “They’re going to spend money, lots of money, to build out capacity.”

    Bank stocks rose following the latest raft of quarterly earnings. Goldman Sachs advanced 4% after its fourth-quarter profit topped Wall Street estimates. Morgan Stanley jumped nearly 6% after its wealth management unit contributed to top and bottom line beats in the fourth quarter. Both stocks touched fresh 52-week highs.

    A pullback in oil prices was also supportive of the market, with Brent crude oil futures and front-end West Texas Intermediate crude both sliding more than 4%.

    The latest economic data also pointed to a solid jobs market. Jobless claims data for the week ending Jan. 10 came in at 198,000, lower than the 215,000 expected by economists polled by Dow Jones.

    Thursday’s comeback comes on the heels of two straight losing sessions on Wall Street, after a spate of political headlines — concerning heightened risks in Iran and Greenland, and the future of Federal Reserve independence — weighed on investor sentiment.

    Nvidia came under pressure earlier this week after a Reuters report, citing individuals briefed on the matter, said Chinese customs authorities advised customs agents this week that the company’s H200 chips are not allowed to enter the country. The chipmaker has since rebounded.

    Continue Reading

  • Hyatt Newsroom – News Releases

    Unlock Free Nights from Spain to South Beach with the World of Hyatt Credit Card from Chase

    New cardmembers can earn up to five free nights at Category 1-4 Hyatt hotels and resorts with a limited-time offer that transforms everyday spending into bucket-list adventures.

    CHICAGO (January 15, 2026) – The World of Hyatt Credit Card from Chase is offering new cardmembers the chance to earn up to five free nights at Hyatt hotels and resorts around the world. Available January 15 through February 26, 2026, this limited-time offer lets new cardmembers earn:

    • 3 free nights at any participating Category 1-4 Hyatt hotel after spending $5,000 on purchases in the first 3 months of account opening AND
    • 2 additional free nights at any of those hotels after spending $15,000 on purchases in the first 6 months.

    These nights can unlock everything from sun-soaked, beachfront stays at Hyatt Centric San Juan Isla Verde to stylish, city getaways that buzz from check-in to checkout at Hotel Genevieve.

    Choose Your Own 2026 Adventure

    With the opportunity to earn up to 5 free nights through the limited time offer (plus countless more through spending on the card), new cardmembers can shape their year through the experiences that matter most. Whether it’s wandering through storied cities, relaxing poolside, or finding renewal in wide-open spaces, here’s just a glimpse of what those nights could become:

    • The Euro Summer Perfector: Make this year’s Euro Summer itinerary a masterclass in effortless curation. Get a front-row seat to the very best the Mediterranean has to offer by using your free night awards at hotels like Hyatt Centric Malta (Category 2), Hyatt Regency Kotor Bay Resort in Montenegro (Category 4) and Grand Hyatt La Manga Club Golf & Spa in Spain (Category 4).
    • The Live Event Connoisseur: Take your fandom out of the group chat and jet off to some of the world’s most electrifying music and sports capitals. Own the weekend at Hyatt Regency Chicago (Category 4), follow the thrill of the next big game all the way to London with a stay at Hyatt Place London City East (Category 4) or immerse yourself in college football at Hyatt House Lansing / University Area (Category 2). No matter the event, level up your gig-tripping adventures.
    • The Sun-Soaked Mood Re-Setter: Swap your winter blues for beach-soaked stays at Dream South Beach in Florida (Category 4) or immerse yourself in a chic boutique hideaway tucked into Mexico City’s effortlessly cool Condesa neighborhood at Hotel San Fernando (Category 4).
    • The Slow-Travel Seeker: Up your seasonal reset game and slip away for a five-night wellbeing immersion. Check out the sun-drenched tranquility of Grand Hyatt Goa (Category 4), the lush quiet of Alila Ubud (Category 4) or the stylish scene at The Standard, Bangkok Mahanakhon (Category 4).

    These free night awards are valid for one year from issuance.

    The Year of Rewards Awaits

    A new year often comes with the question of which trips are worth planning and how to pay for them. With the World of Hyatt Credit Card, cardmembers can earn points on the purchases they already make, turning everyday moments into more rewarding stays. Even if only planning a single getaway this year, the card can make every swipe work harder for cardmembers, thanks to the accelerator categories. Paired with complimentary elite status and stackable rewards, cardmembers can unlock unforgettable travel experiences faster in 2026.

    In addition to the welcome offer, for every eligible $1 USD spent, cardmembers earn:

    • Up to 9X total points for Hyatt stays (4 Bonus Points per $1 spent on qualifying purchases at Hyatt hotels and resorts, and up to 5 Base Points per eligible $1 spent for being a World of Hyatt member).
    • 2X Bonus Points per every $1 spent on dining; airline tickets purchased directly from the airline, gym memberships, and local transit and commuting.
    • Complimentary World of Hyatt Discoverist status that provides special perks like late checkout (2 p.m.) as available, room upgrades based on availability, and waived resort fees on Free Night Awards.
    • 1X Bonus Point per $1 spent on all other card purchases.
    • A free night award at any Category 1-4 Hyatt hotel or resort each year on your cardmember anniversary.

    Five free nights can take you almost anywhere with World of Hyatt; the only question is where you want to go first? From long-imagined getaways to unplanned adventures, design a year filled with the moments that matter most. To take advantage of this offer, apply for the card by February 26, 2026.

    To learn more, visit chase.com/HyattLTO and start planning your first (or second… or third…) adventure. For more information about Hyatt hotels and resorts, visit Hyatt.com.

    The term “Hyatt” is used in this release for convenience to refer to Hyatt Hotels Corporation and/or one or more of its affiliates.

    Credit Cards are issued by JPMorgan Chase Bank, N.A. Member FDIC. Accounts subject to credit approval. Restrictions and limitations apply. Offer subject to change.

    About Hyatt Hotels Corporation

    Hyatt Hotels Corporation, headquartered in Chicago, is a leading global hospitality company guided by its purpose – to care for people so they can be their best. As of September 30, 2025, the Company’s portfolio included more than 1,450 hotels and all-inclusive properties in 82 countries across six continents. The Company’s offering includes brands in the Luxury Portfolio, including Park Hyatt®, Alila®, Miraval®, Impression by Secrets, and The Unbound Collection by Hyatt®; the Lifestyle Portfolio, including Andaz®, Thompson Hotels®, The Standard®, Dream® Hotels, The StandardX, Breathless Resorts & Spas®, JdV by Hyatt®, Bunkhouse® Hotels, and Me and All Hotels; the Inclusive Collection, including Zoëtry® Wellness & Spa Resorts, Hyatt Ziva®, Hyatt Zilara®, Secrets® Resorts & Spas, Dreams® Resorts & Spas, Hyatt Vivid® Hotels & Resorts, Sunscape® Resorts & Spas, Alua Hotels & Resorts®, and Bahia Principe Hotels & Resorts; the Classics Portfolio, including Grand Hyatt®, Hyatt Regency®, Destination by Hyatt®, Hyatt Centric®, Hyatt Vacation Club®, and Hyatt®; and the Essentials Portfolio, including Caption by Hyatt®, Unscripted by Hyatt, Hyatt Place®, Hyatt House®, Hyatt Studios®, Hyatt Select, and UrCove. Subsidiaries of the Company operate the World of Hyatt® loyalty program, ALG Vacations®, Mr & Mrs Smith, Unlimited Vacation Club®, Amstar® DMC destination management services, and Trisept Solutions® technology services. For more information, please visit www.hyatt.com.

    About World of Hyatt

    World of Hyatt is Hyatt’s award-winning guest loyalty program uniting participating locations in Hyatt’s Luxury Portfolio, including Park Hyatt®, Alila®, Miraval®, Impression by Secrets, and The Unbound Collection by Hyatt®; the Lifestyle Portfolio, including Andaz®, Thompson Hotels®, The Standard®, Dream® Hotels, The StandardX, Breathless Resorts & Spas®, JdV by Hyatt®, Bunkhouse® Hotels, and Me and All Hotels; the Inclusive Collection, including Zoëtry® Wellness & Spa Resorts, Hyatt Ziva®, Hyatt Zilara®, Secrets® Resorts & Spas, Dreams® Resorts & Spas, Hyatt Vivid Hotels & Resorts, Sunscape® Resorts & Spas, and Alua Hotels & Resorts®; the Classics Portfolio, including Grand Hyatt®, Hyatt Regency®, Destination by Hyatt®, Hyatt Centric®, Hyatt Vacation Club®, and Hyatt®; and the Essentials Portfolio, including Caption by Hyatt®, Hyatt Place®, Hyatt House®, Hyatt Studios, and UrCove. Members who book directly through Hyatt channels can enjoy personalized care and access to distinct benefits including Guest of Honor, confirmed suite upgrades at time of booking, diverse wellbeing offerings, digital key, and exclusive member rates. World of Hyatt offers a variety of ways to earn and redeem points for hotel stays, dining and spa services, wellbeing focused experiences through the FIND platform; as well as the benefits of Hyatt’s strategic loyalty collaboration with American Airlines AAdvantage®. Travelers can enroll for free at hyatt.com, download the World of Hyatt app for android and IOS devices and connect with World of Hyatt on Facebook, Instagram, TikTok and X.

    Media Contact:

    Kaitlyn Sheehy

    kaitlyn.sheehy@hyatt.com

    Continue Reading