Category: 3. Business

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  • Sequoia Plans for More AI, Less Partisanship Under Grady and Lin – Bloomberg.com

    1. Sequoia Plans for More AI, Less Partisanship Under Grady and Lin  Bloomberg.com
    2. Sequoia Capital Leader Exits in VC Shake-Up  The Wall Street Journal
    3. Sequoia’s Change in Leadership: Will Advancements in AI Help Restore Broken Trust?  Bitget
    4. Sequoia Capital elevates Alfred Lin and Pat Grady to lead venture capital firm  Pensions & Investments
    5. Meet Sequoia Capital’s new stewards  Fortune

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  • Ten organizations have jointly launched a project titled “Development of Integrated Simulation Platform for Sustainable and Competitive Maritime Industry”

    Ten organizations have jointly launched a project titled “Development of Integrated Simulation Platform for Sustainable and Competitive Maritime Industry”

    1.Project Title:

    Development of Integrated Simulation Platform for Sustainable and Competitive Maritime Industry

    2.Project Leader:

    Hideyuki ANDO, Director of MTI

    3.Co-Leaders:

    MHIMSB Shingen TAKEDA
    Senior Vice President, CTO,
    Head of Marine Engineering Center
    TSUNEISHI Kazutaka SEKI
    General Manager, Ship Planning Dept. & Model Based Design Promotion Dept., Design Div.
    JAMSTEC Yasumasa MIYAZAWA
    Principal Researcher, Seasonal Prediction Center for Shipping Digital Transformation
    JMU Yutaka NISHIMURA
    General Manager, Corporate Planning Department
    MITSUI E&S Kazutaka SHIMADA
    Deputy General Manager, Engine Design Dept.
    NMRI Kunihide OHASHI
    Deputy Director, Fluids Engineering and Ship Performance Evaluation Department
    TSUNEISHI AKISHIMA Koyu KIMURA
    Director, Head of Research & Development Division
    UOsaka Atsuo MAKI
    Professor, Division of Global Architecture
    Graduate School of Engineering
    KU Takeshi ENOMOTO
    Professor, Disaster Prevention Research institute

    4.Project Outline:

    The focus of ship demand will shift toward high-performance next-generation ships that adopt alternative fuels to reduce greenhouse gas emissions, energy-saving technologies such as wind propulsion, and advanced integrated control systems including autonomous navigation. Japan’s maritime industry faces the challenge of developing and supplying next-generation ships with increasingly sophisticated and complex functions in shorter lead time, while also expanding its shipbuilding capacity to meet growing global demand amid a declining labor force.
    To address this, this research and development project will establish an “Integrated Simulation Platform” that enables simultaneous consideration of ship lifecycle and supply chain, at the initial development and design stages, to optimize ship design and construction plans. This project will promote the implementation of virtual engineering concept and techniques into the maritime industry.
    Additionally, regarding weather and sea condition predictions that impact the safe and stable ship operations, a seasonal prediction technology, covering 1 to 3 months in advance, including extreme phenomena such as typhoons, will be developed and integrated into the platform.

    5.Research and Development Items

    Research on Implementation of Integrated Simulation Platform in Society
    Leader: Hideyuki ANDO, MTI
    Participating Organizations: MTI / MHIMSB / TSUNEISHI / JAMSTEC

    Research on Preemptive Development Simulator
    Leader: Kazutaka SEKI, TSUNEISHI
    Participating Organizations: TSUNEISHI / MTI / TSUNEISHI AKISHIMA / NMRI / MITSUI E&S / MHIMSB / JMU

    Research on Ship Design and Ship Building
    Leader: Hiroshi TANAKA, MHIMSB
    Participating Organizations: MHIMSB / JMU / NMRI

    Research on Commissioning and Sea Trial
    Leader: Kiyoko SUGIYAMA, TSUNEISHI
    Participating Organizations: TSUNEISHI / MTI / MITSUI E&S / UOsaka / TSUNEISHI AKISHIMA

    Research on Operation and Maintenance Simulator
    Leader: Ryo KAKUTA, MTI
    Participating Organizations: MTI / TSUNEISHI / TSUNEISHI AKISHIMA / UOsaka / MITSUI E&S

    Research on Seasonal Meteorological and Oceanographic Forecast Simulator
    Leader: Yasumasa MIYAZAWA, JAMSTEC
    Participating Organizations: JAMSTEC / KU / MTI /

    6.Project Period:

    5 years from October 1st, 2025 to September 20th, 2030

    Based on the components of the Integrated Simulation Platform, research and development will be promoted across six R&D items. In 2028, an interim evaluation including a stage-gate assessments will be conducted, and by 2030, the deliverables from each R&D topic will be integrated into the Integrated Simulation Platform (see diagram below), aiming for its demonstration in the design and construction of actual ships.

    Components of the Integrated Simulation Platform

    7.Project Budget:

    Maximum JPY 12 billion

    • Total budget for the R&D Project

    8.Contact Information:

    MTI Co., Ltd.
    JCAST Project Management Office under K Program
    E-mail: [email protected]

    9.Related Links:

    1. JST Press Releases (in Japanese)
      https://www.jst.go.jp/pr/info/info1772/index.html
    2. “Development of Integrated Simulation Platform for Sustainable and Competitive Maritime Industry” has been selected as a R&D project under K Program
      https://www.monohakobi.com/en/company/news/news_20250708/
    3. Additional Call for Proposals for R&D topic 6 of “Development of Integrated Simulation Platform for Sustainable and Competitive Maritime Industry” (in Japanese)
      https://www.monohakobi.com/ja/company/news/news_20250902/

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  • Stocks falter below 160,000 on weak trade data – Dawn

    1. Stocks falter below 160,000 on weak trade data  Dawn
    2. KSE-100 loses momentum, sheds over 1,500 points  Business Recorder
    3. PSX slumps over 1,700 points as investor sentiment weakens  The Express Tribune
    4. PSX drops over 1% as profit-taking weighs on market  Profit by Pakistan Today
    5. PSX stays bearish, loses 1,703 more points  Associated Press of Pakistan

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  • China’s Trade Truce and Five-Year Plan Help Coal Price Recover – Bloomberg.com

    1. China’s Trade Truce and Five-Year Plan Help Coal Price Recover  Bloomberg.com
    2. Expectations of a ‘cold winter’ support strong coal prices during the heating season, driving a short-term rally in Hong Kong-listed coal stocks.  富途牛牛
    3. Asian Coal Imports Set for Decline on Higher Prices  Crude Oil Prices Today | OilPrice.com
    4. Cathay Pacific Haitong: Bottom of the coal sector cycle confirmed, multiple factors driving supply-demand reversal  富途牛牛
    5. Open Source Securities: Coal prices are experiencing inertia-driven increases, and the supply-demand fundamentals of the coal market are expected to continue improving.  富途牛牛

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  • China’s WeRide drives towards ‘ubiquitous’ robotaxi service after Hong Kong listing

    China’s WeRide drives towards ‘ubiquitous’ robotaxi service after Hong Kong listing

    Chinese self-driving technology firm WeRide, fresh off raising HK$2.39 billion (US$307 million) in a Hong Kong share sale, plans to rev up commercialisation of autonomous taxis and expand into markets like the Middle East, Southeast Asia and Japan.

    Tony Han, founder and CEO of the Guangzhou-based company, said WeRide would deploy 10,000 robotaxis worldwide over the next few years, adding that its fleet could eventually grow to hundreds of thousands in line with the ultimate goal of “supplying more ubiquitously available global taxi service”.

    “WeRide, as the first mover and industrial leader in the self-driving industry, will expand to the global market,” he said, adding that the proceeds from the Hong Kong offering would support research and development as well as geographic expansion.

    Han said WeRide also planned to roll out different lines of businesses, such as using premium-level autonomous cars to provide taxi service to wealthy customers.

    “But we definitely will focus on supplying very efficient or economically efficient services to the working class or normal people,” he added.

    WeRide, which already trades on the Nasdaq market, made its Hong Kong trading debut on Thursday, where its shares fell 14 per cent to HK$23.22 at the start of trading. The firm priced its Hong Kong shares at HK$27.10 apiece, a premium of 11.5 per cent to its Tuesday close of US$9.40 on the Nasdaq. One American depositary share is equal to three ordinary shares.

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  • Chinese researchers reveal nicotinamide’s heart-protective effect in tumor treatment

    Chinese researchers reveal nicotinamide’s heart-protective effect in tumor treatment

    LANZHOU — Chinese researchers have revealed the heart-protective effect of nicotinamide — a derivative of B vitamins — in exploring the mechanisms of related cardiotoxicity in tumor treatment, according to Lanzhou University.

    Their study uncovered the mechanisms by which immune checkpoint inhibitors induce early cardiotoxicity, and developed a new, safe and effective approach to preventing and treating cardiotoxicity in patients receiving tumor immunotherapy, the university said.

    Conducted by researchers at the Lanzhou University First Hospital, the study has been published in the Science China: Life Sciences journal.

    Having the potential to result in death, cardiac immune-related adverse events associated with anti-programmed cell death protein 1 (PD-1), which is a type of immune checkpoint inhibitor, are becoming a concern. This study aimed to explore effective means of early warning and prevention, according to Bai Ming, a professor at the Lanzhou University First Hospital and the study”s leader.

    The team first investigated the role of PD-1 in the early stages of cardiotoxicity and its underlying mechanisms by combining clinical data with experiments.

    Then, the researchers conducted randomized controlled trials to verify the preventive effect of nicotinamide against early cardiotoxicity related to PD-1.

    Their findings showed that nicotinamide demonstrates potential in preventing cardiotoxicity in patients receiving anti-PD-1 cancer treatment, according to Bai.

    The clinical transformation of this research also confirmed that nicotinamide — a drug commonly used in clinical practice — is suitable for rapid transformation and application.

    Nicotinamide therapy focuses on “early” cardiotoxicity, making it possible to prevent and treat cardiotoxicity. Therefore, this therapy highlights the concept of synergistic treatment that ensures anti-tumor efficacy while protecting heart functions, per the study.

    “The findings of the study contribute to a better understanding of cardiac anti-PD-1 immune-related adverse events. They show that nicotinamide could be a promising preventive strategy in the early stages of cardiotoxicity, which is associated with the use of such checkpoint inhibitors in cancer treatment,” Bai said.

    “Therefore, this study sheds new light on the well-considered safety issues in tumor treatment,” he added.

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  • Stock Market Today: Dow, S&P Live Updates for November 6

    Stock Market Today: Dow, S&P Live Updates for November 6

    Asian stocks tracked Wall Street’s gains after dip buyers returned following a brief pullback in technology shares, and signs of a resilient US labor market lifted sentiment.

    MSCI’s regional stock gauge rose 0.9%, with Hong Kong and Japan among the gainers. Contracts for the Nasdaq 100 index fell as much as 0.3% after Qualcomm Inc., the largest maker of smartphone processors, became the latest chipmaker to deliver an upbeat forecast and still leave investors underwhelmed. Its shares retreated 2% in late trading. Futures for the S&P 500 fell 0.2%.

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  • Saudi Arabia cuts December oil prices for Asia as OPEC+ boosts output

    Saudi Arabia cuts December oil prices for Asia as OPEC+ boosts output

    Nov 6 (Reuters) – Saudi Arabia, the world’s top oil exporter, has sharply reduced the prices of its crude for Asian buyers in December, responding to a well-supplied market as OPEC+ producers ramp up production.

    State oil giant Saudi Aramco set its December official selling price at $1 per barrel above the Oman/Dubai average, marking the first price reduction since October after it kept rates unchanged in November.

    Sign up here.

    The December prices for other grades – Arab Medium and Arab Heavy – fell by $1.40 each to five cents and 10 cents a barrel, while that for Arab Extra Light dropped by $1.20 to $1.30 a barrel, the document said.

    The pricing decision came shortly after the Organization of the Petroleum Exporting Countries and its allies, or OPEC+, agreed on Sunday to a modest oil output increase for December, followed by a pause in production hikes during the first quarter of next year. The producers’ alliance opted to moderate its push to reclaim market share amid growing concerns over a potential global supply glut.

    OPEC+ has raised output targets by around 2.9 million barrels per day, or about 2.7% of global supply, since April, but slowed the pace from October amid predictions of a looming oversupply.

    The price cuts are within market expectations, according to a Reuters survey.

    Saudi Aramco determines its crude oil prices by incorporating feedback from customers and assessing monthly changes in the value of its oil, which are influenced by product prices and market yields.

    As a matter of policy, Saudi Aramco officials do not comment on the kingdom’s monthly OSPs.

    Below are Saudi prices for December in dollars per barrel.

    Reporting by Sarah Qureshi and Ishaan Arora in Bengaluru; Editing by Chris Reese and Sherry Jacob-Phillips

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  • DoorDash expects bigger investments next year and a little less from Deliveroo; stock sinks

    DoorDash expects bigger investments next year and a little less from Deliveroo; stock sinks

    By Bill Peters

    ‘We wish there was a way to grow a baby into an adult without investment … but we do not believe this is how life or business works,’ company says

    DoorDash’s autonomous delivery vehicle, Dot.

    Shares of DoorDash Inc. tumbled in extended trading Wednesday, after the delivery platform said it plans to increase investments in its business next year and that its recent acquisition of Deliveroo would contribute less to profits in 2026 than once anticipated.

    DoorDash’s stock (DASH) fell more than 9% after hours. However, the stock is still up around 42% so far this year.

    The company said it expects to invest several hundred million dollars more in “new initiatives and platform development” in 2026 than it did last year, as it tries to expand internationally, compete with rivals’ overlapping services and roll out new technology to make orders faster and more precise.

    “We wish there was a way to grow a baby into an adult without investment, or to see the baby grow into an adult overnight, but we do not believe this is how life or business works,” the company said in a statement announcing its third-quarter earnings.

    DoorDash reported third-quarter revenue of $3.45 billion, up 27% from the same quarter last year and above FactSet analyst forecasts for $3.36 billion. The company earned 55 cents a share during the quarter, below estimates for 68 cents.

    DoorDash’s gross order value, or the total dollar value of orders made on the platform, jumped 25% year over year to $25 billion in the third quarter. That was above expectations for $24.53 billion.

    For the fourth quarter, DoorDash forecast $28.9 billion to $29.5 billion in gross order value. That outlook was above Wall Street’s forecast for $26.55 billion.

    However, DoorDash said its purchase last month of Deliveroo – a London-based delivery company that operates in several nations in Europe, Asia and the Middle East – wouldn’t deliver as much to its adjusted profits as it initially thought.

    DoorDash said that due to differences with Deliveroo’s accounting protocols, “we estimate that aligning our accounting treatment and definitions will reduce Deliveroo’s contribution to our reported adjusted Ebitda in 2026 by approximately $32-40 million compared to what weestimate it would have reported prior to our acquisition.” (Ebitda stands for earnings before interest, taxes, depreciation and amortization.)

    DoorDash, known for its delivery and takeout services for restaurants, has over recent years been trying to deliver more items from grocery stores and other retailers in an effort to become a bigger part of local economies.

    In September, the company announced the launch of new features, including a new autonomous delivery robot, called Dot, and services like restaurant reservations. Ethan Feller, a stock strategist at Zacks Investment Research, said that the move showed how DoorDash had helped turned online delivery services into an expectation. He said the expansion risked overlap with other companies – and a “commoditization” of those services – but noted that they could be discarded if they didn’t work.

    In September, DoorDash and supermarket chain Kroger Co. (KR) said they would expand their partnership to deliver more groceries to shoppers’ homes. Some analysts said the announcement marked a bigger threat to grocery-delivery platform Instacart (CART).

    -Bill Peters

    This content was created by MarketWatch, which is operated by Dow Jones & Co. MarketWatch is published independently from Dow Jones Newswires and The Wall Street Journal.

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    11-05-25 2028ET

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