Category: 3. Business

  • Interview with Cyprus News Agency

    V češtině není k dispozici.

    Interview with Piero Cipollone, Member of the Executive Board of the ECB, conducted by Thalia Neophytou on 6 February 2026

    8 February 2026

    The idea of a digital euro has raised many questions across Europe. Could you explain why the ECB is moving ahead with it and what practical impact it could have for citizens, households and businesses?

    First, let me clarify that we have not yet issued a digital euro and we will not do so until we have the legislation in place.

    Having said that, we think that issuing the digital euro is a good idea, especially for citizens. It will preserve their freedom to pay with money issued by their central bank – their money. And today cash cannot be used in many cases – for example, when paying online. The digital euro would let you keep the benefits of cash for those use cases where central bank money cannot currently be used. In short, with the digital euro we are creating a digital version of cash.

    For citizens, the major advantage is simplicity. With one piece of hardware, you can pay everywhere in Europe, in all use cases – it is simple and gives you the freedom to pay how you want. For businesses, especially for small businesses like those that make up the backbone of the Cyprus economy, the digital euro will help them save money. This is because with the digital euro the cost of accepting digital payments will be much lower than it is today.

    If citizens already pay digitally using private mobile wallets, why do we need a central bank digital currency?

    First of all because the market is very fragmented. If you want to cover all your needs, you need several pieces of equipment. This means that, if you want to pay, some solutions don’t work online, some solutions don’t work in shops – and so you have to carry them all with you to ensure you can pay in all scenarios. The digital euro will give you one instrument that allows you to pay everywhere. There is additional functionality that is not available today – for example, an offline solution that will allow you to pay with digital euro even when there is no electricity and you aren’t connected to the internet.

    So, to answer your question: we need it because of its simplicity and its coverage of all use cases online and coverage of additional use cases with the offline solution. It is very advantageous for consumers.

    Although, if I may, there is something in this point that we should bear in mind – we sometimes speak too much about consumers, but we shouldn’t forget that consumers are also citizens, and as citizens we should all be concerned about the resilience of the means of payment we use.

    At the moment, almost 70% of card-initiated transactions, are processed by non-European companies. This speaks to the resilience issue – you hear all this talk about strategic autonomy and resilience and yet for something as fundamental as payments we rely mostly on non-European companies. As European citizens, we should be concerned about this. With the digital euro we will solve this problem.

    Why would a digital euro matter to a small, bank-based economy like Cyprus?

    It will be very advantageous, especially for Cyprus. Today, you have to use non-European means of payment. And this doesn’t come for free. Accepting payments via international card schemes is expensive, especially for smaller merchants. We can estimate that, especially for small businesses, it costs three to four times as much as it would for a larger merchant.

    The digital euro would significantly reduce this cost because the ECB will not charge any scheme fees. So, we reduce the cost of the transaction and the merchants benefit. Moreover, because there is an alternative option for accepting digital payments, smaller merchants will gain some strength in negotiations when it comes to private solutions. This is competition.

    Why is the ECB moving ahead now, at a time when other central banks have postponed or even abandoned plans for a central bank digital currency?

    Well, first of all, it is not clear that all others have abandoned or postponed it. It depends on the central bank. But it is important that we think about ourselves and look to our needs. The ECB is responsible for providing means of payment in Europe and for ensuring the resilience and the reliability of the payment system.

    We have to ask ourselves: are these conditions met in Europe today? As I said before, the situation is currently so fragmented that these conditions are not always met. These are the needs we have in Europe, and we need to act now. If we waste time – if we keep spending time thinking about other people – our situation and our dependency on non-European payment providers will deepen and we will end up in a worse position.

    Where do we currently stand with introducing the digital euro, and what are the key milestones ahead?

    There are two dimensions here. The internal dimension – the preparedness dimension that is the responsibility of the ECB and the Eurosystem – and then there is the legislation side.

    On the legislation side we are now progressing well. The original proposal from the European Commission was issued in June 2023. In December last year, the Council of the European Union reached an agreement that is pretty close to the Commission’s original position. Now we are waiting for the European Parliament to come to a decision.

    According to the latest proposed schedule, in May they should be able to vote for a position, and we know that they are actively discussing the amendments. So hopefully by May we will have a position from Parliament. Then they will be able to negotiate and hopefully by the end of the year we will have the legislation.

    We are already working to be prepared to be able to issue the digital euro, if the legislation is in place, by mid-2029. In the meantime, we will start a pilot in 2027 – this means we will then start initiating some payments on a pilot basis.

    But we have to wait until 2029 for the currency to be released?

    Think of it this way: to actually produce the infrastructure and to be able to issue, it will take us as much time as the legislator needs for the legislation.

    Banks have expressed concerns that the digital euro could affect their liquidity through deposit outflows. How is the ECB addressing these concerns?

    This is something we have been thinking about from the very beginning. Obviously, because – as you can imagine – the stability of banks is a major concern for the ECB, as our monetary policy transmits via banks. We built in some safeguards from the outset.

    First, the digital euro will not be remunerated, so there is no incentive for people to move money out of their bank account and into their digital euro account.

    Second, you won’t need to have the money in your digital euro wallet to make a payment because we will have a waterfall solution in place. Put simply, this means that whenever you make a digital payment with digital euro, the money will be downloaded from your bank account, put in the digital euro wallet and, from there, paid to the recipient. You won’t need to prefund it.

    Will this be online or offline?

    Online, which will be the larger use case. For offline, obviously, you need to have the money in the wallet beforehand.

    As a third point, to continue my previous answer, there will be holding limits.

    And fourth, only physical people can have the digital euro, not merchants. This will also reduce demand. We have run simulations on this and in our analysis, even for relatively high holding limits, we don’t see any financial instability.

    This is public knowledge. We published a report that we sent to the European Parliament which clearly shows that this is the case. Financial stability is not endangered.

    How much will the holding limit be?

    We don’t know yet. That is still to be discussed. There is a robust process for that, which involves the European Central Bank, the European Commission and the Council.

    It will be a comprehensive, clearly articulated process to ensure that nobody can make a sudden decision to change the holding limit. It will be a very robust process that will have at its centre exactly the point you were raising: reassurance that financial stability will be maintained.

    So besides financial stability, trust is important for success or failure of the project. What guarantees can you give citizens on privacy and data protection?

    We have built the whole project around privacy. Why is this? Because at the very beginning of the process, we looked into people’s expectations. We heard two things: privacy and resilience. Those were the major concerns that people raised.

    We have built the system around that. How do we ensure that privacy is protected? For the online solution, we will not have people’s data. We will not know who is paying whom. All the ECB will see is encrypted codes that represent the payer and the payee, but we will not be able to identify the individuals behind these codes. The information stays with the banks, very much like today. The ECB will not know any data. This is for the online solution.

    For the offline solution, only the payer and the payee will know the transaction details because a concrete transfer of money will take place between their devices. This is the highest level of privacy that you can get for the current technology. We are on the frontier, so obviously we implement solutions as they develop.

    And a question on monetary policy. With the euro strengthening against the dollar, does this give the ECB more room to cut interest rates, or is the exchange rate not a driver of policy decisions?

    We do not have a specific target for the exchange rate. Obviously, we take into account the exchange rate as an input in our projections. This is part of all the range of inputs that we take into account to project inflation dynamics. And we will see how the new projections match and the impact this will have.

    The euro has appreciated at the beginning of 2026. It has been bunching around 1.18, 1.17 against the dollar for almost a year now. After the episode we saw a couple of weeks ago it is now back to levels seen in previous months.

    Continue Reading

  • ‘16 years later, I’m not unhappy’: the rise of Britain’s multigenerational flatmates | Housing

    ‘16 years later, I’m not unhappy’: the rise of Britain’s multigenerational flatmates | Housing

    When Nicola Whyte first moved into a four-bedroom house share in Balham 16 years ago, she never imagined she would still be living there at 45. But with rents soaring, and ongoing challenges in saving up for a house deposit, she has ended up as a housemate far longer than she anticipated.

    “I didn’t think I was going to be here 16 years later, but I’m not unhappy,” she said. “My friends sometimes think I’m a bit weird, they ask me how I can still do it. But I really enjoy it. The rent is really reasonable, it’s close to work and I think it gives you a deeper understanding of people.”

    Data from SpareRoom, the UK’s leading website for flat and house shares, has shown a significant shift in the market in recent years, with roommates under 35 in decline and those aged over 35 on the rise.

    Their survey of more than 3,500 flatmates showed that under-25s now make up just 26% of the market, down from 32% a decade ago, while renters 45 and above now make up 16%, up from 10% in 2015.

    The rise in older flatmates has also led to a rise in multigenerational households – almost two-fifths of flatmates said they lived in a house where the age difference between the oldest and youngest adult was 20 years or more.

    Whyte’s youngest current flatmate is 28, 17 years younger than her, and over the years she has lived with people from 21 to their late 40s. Mostly everyone gets along well, although the large age gaps have sometimes thrown up problems when people have different ideas of housemate etiquette.

    An older, more independent housemate might struggle with collegiate decision-making, while younger tenants may be more likely to keep antisocial hours or have parties.

    “There have been some people who didn’t really fit in” said Whyte, who works for the local council. “But really, it’s less about someone’s age and more about who they are as a person.”

    Experts say a combination of fewer under-25s leaving home, and older renters being priced out of home ownership and renting solo, is thought to be fuelling the change in housemate demographics. “People think of flat sharing being a young people’s game but the older cohort are growing by far the fastest,” said Matt Hutchinson, the director of SpareRoom.

    “Older people are sharing for longer and there’s this preconception that people want to live with people just like them, but actually some people prefer to live with people of different ages, different backgrounds.”

    Another key factor behind the rise of age-gap house shares is over-65s sharing their homes with lodgers, something that has increased by 38% over the past two years according to SpareRoom.

    When Thea May, 29, moved to south-west Wales for a new job, she found there was “literally nowhere” to rent – everything was either too expensive or in poor condition.

    In desperation, her mum posted on a local Facebook group and 67-year-old Paul Williams replied – after his daughter moved out for university, he had a spare room and was looking for some company.

    Williams, 67, was looking for some extra income and felt sharing his space was the morally right thing to do. Photograph: Adrian Sherratt/The Guardian

    “I did initially think: he’s a man who’s a lot older than me, is this a wild idea? But it really wasn’t, we just got on straight away,” said May. “It provides a level of purpose, friendship and companionship for both of us.

    “I don’t think I ever really notice the age gap. It mostly shows itself in the way that it confounds expectations, like sometimes if I say I don’t fancy watching TV because I want to do my crochet, he’ll say: are you actually 29? We just bumble along.

    “I feel very lucky and it’s quite a profound experience. I do hope to be able to buy a home, but living near to Paul is a massive factor now.”

    Williams, who was looking for some extra income and felt sharing his space was the morally right thing to do, never expected the pair’s friendship to blossom in the way it has.

    “I thought she would live upstairs and we wouldn’t see much of each other,” he said. “But I can’t believe my luck in how we’ve hit it off. My friends will say: I don’t think I’d want to live with a stranger like that. But she’s not a stranger, there is a friendship now and a bond.”

    Nick Henley, a co-founder of Cohabitas, a house-sharing site for over-40s, said 18% of the last 5,000 people who registered said they would be open to living in an intergenerational home.

    On their platform, this can mean in traditional house shares, or things like a “helpful housemate” setup, where people move in with an older person to help with chores or for companionship.

    “I think the majority of people will have to house share in the future, that’s the way things are going,” said Henley. “We need developers to start building shared housing, but it’s not happening. They’re building small places, single dwellings for young people.”

    Housing charities have warned that homelessness among over-60s is rising, and single older people are increasingly likely to end up in house shares if they don’t own a property as they head into retirement.

    SpareRoom said the proportion of flatsharers who are 65 and above has tripled in the past decade, although accounts for only 2.4% of the market.

    “I can’t quite understand why it’s not a bigger topic, that we have a generation of people who can’t afford to buy a home,” said Hutchinson. “It’s a ticking timebomb that’s just waiting to go off.”

    Continue Reading

  • Assessing Fluor (FLR) Valuation After Recent Share Price Momentum And Mixed Return Track Record

    Assessing Fluor (FLR) Valuation After Recent Share Price Momentum And Mixed Return Track Record

    Get insights on thousands of stocks from the global community of over 7 million individual investors at Simply Wall St.

    Fluor (FLR) has been drawing fresh attention after recent share price moves, with the stock up over the past week, month, and past 3 months, putting its longer term performance back in focus for investors.

    See our latest analysis for Fluor.

    That latest move takes Fluor’s share price to $46.92 and adds to a 12.52% year to date share price return. The 1 year total shareholder return of a 4.90% decline contrasts with a 161.39% gain over 5 years, which may suggest longer term momentum alongside recent volatility in how the market is pricing its risks and prospects.

    If this kind of price action has you looking beyond a single contractor, it could be a moment to check out 24 power grid technology and infrastructure stocks as another way to find infrastructure related opportunities.

    With Fluor trading at $46.92, a value score of 3, and a share price sitting below the average analyst target of $50.50, investors may ask whether this reflects a genuine mispricing or whether expectations about future growth are already fully reflected in the current price.

    Fluor’s most followed narrative points to a fair value of $51.00, a touch above the recent $46.92 close, which puts the current analyst thinking in the spotlight.

    The company’s new strategy focusing on cash generation and earnings growth is likely to improve net margins and enhance earnings. Expansion into strategic markets, coupled with project completions and acquisitions, is expected to increase revenue and enhance shareholder value.

    Read the complete narrative.

    Curious how a view of mid single digit revenue growth, thinner profit margins, and a higher future earnings multiple still add up to that $51.00 fair value? The full narrative lays out the math behind that tension.

    Result: Fair Value of $51.00 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, there are still pressure points, including project delays that affect the timing of revenue and margins, as well as cost or collection issues that weigh on cash flow.

    Find out about the key risks to this Fluor narrative.

    While the consensus narrative points to a fair value of $51.00, our DCF model paints a different picture, with an estimate of $38.79 and Fluor trading at $46.92. That suggests the shares are priced above future cash flow estimates. Which perspective do you think deserves more weight?

    Look into how the SWS DCF model arrives at its fair value.

    FLR Discounted Cash Flow as at Feb 2026

    Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Fluor for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 52 high quality undervalued stocks. If you save a screener we even alert you when new companies match – so you never miss a potential opportunity.

    If you see the story differently or want to stress test the assumptions yourself, you can pull the numbers, set your own views, and Do it your way in just a few minutes.

    A great starting point for your Fluor research is our analysis highlighting 3 key rewards and 2 important warning signs that could impact your investment decision.

    If Fluor has sharpened your focus, do not stop here. Put the same disciplined thinking to work across other opportunities before the market moves without you.

    • Target quality at a discount by scanning our 52 high quality undervalued stocks, built to surface companies with strong fundamentals priced below what many investors might expect.

    • Steady your portfolio with income focused opportunities by reviewing our 14 dividend fortresses, highlighting businesses offering 5%+ yields that aim to pair stability with cash returns.

    • Strengthen your downside protection by checking our 82 resilient stocks with low risk scores, featuring companies flagged for resilient balance sheets and lower overall risk scores.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include FLR.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • Connecting home solar and electric vehicle batteries to the grid could boost South Africa’s clean energy and strengthen the electricity system

    Connecting home solar and electric vehicle batteries to the grid could boost South Africa’s clean energy and strengthen the electricity system

    South Africa has committed to reaching phasing out human-caused carbon pollution by 2050. To get there, it needs to push as much renewable energy as possible into the national grid.

    The country is the world’s 15th largest carbon polluter. It’s one of only a handful of countries still heavily dependent on burning coal to generate electricity. The country’s transport system is totally reliant on crude oil and its derivatives.




    Read more:
    What’s stopping sunny South Africa’s solar industry? Court case sheds light on the wider problem


    One of the keys to the transition to net zero is decarbonising household energy consumption. This means finding ways for homes to reduce the greenhouse gases that cause global warming. At the moment, household energy use contributes up to 40% of total emissions.

    I am an engineer and technology management specialist who recently researched how South Africa could use excess clean power from rooftop solar systems on homes if it was fed into the grid. I also studied how battery electric vehicles could be used to store solar energy at home, and feed this into the grid too.

    The following analogy explains the idea: think of South Africa’s current solar energy potential like a leaking rainwater tank. It has plenty of “rain” (sunlight). But because it lacks the “pipes” (bidirectional meters) and “extra buckets” (electric vehicle batteries), half of that “water” (clean energy) spills onto the ground unused.




    Read more:
    How South Africa can spread renewable energy to low income areas


    Instead, a system could be built that captures every drop of sunlight. This solar energy could be shared between the house, the car, and the neighbours to ensure the whole community has enough. Commercial projects based on this approach are already operational in China, Japan and Germany.

    The biggest obstacle to this idea in South Africa is that both small-scale solar and electric vehicles are too expensive for most households, as we showed in two recently published studies on solar electricity for homes and electric vehicles.




    Read more:
    Electric vehicles in South Africa: how to avoid making them the privilege of the few


    Fortunately, there is a solution: the aggressive use of two technologies. The first would be giving every home with solar power a bidirectional (two-way) meter. This is a meter that allows homeowners to sell their excess solar power back to the grid. The second would be giving electric vehicle owners a vehicle-to-grid device so that they could store excess solar power in their electric vehicle batteries and sell it back to the national grid.

    We believe that a synchronised effort between two novel technology adoptions – infrastructure modernisation (installing bidirectional smart grids and vehicle-to-grid devices in homes) – could dramatically increase the country’s clean energy production.

    Energy from small-scale embedded solar systems

    Rooftop solar systems installed on residential buildings are estimated to generate about 40% more energy than the residences need. This is because most rooftop solar systems are set up to generate enough energy to power a house during winter when the demand is greatest – people run heaters and tumble driers – and sunlight is at its weakest.




    Read more:
    Home solar systems in South Africa: more will be installed if households are given loans, free maintenance and security


    If these homes were fitted with bidirectional meters, which are already widely available, they could sell their unused solar power back to the grid.

    Municipalities could also benefit by buying the excess renewable energy generated by homes and reselling it. In Cape Town alone, the city would generate an estimated R144 million (US$8.8 million) per year from doing this, equivalent to an additional 3% in profit, if the bidirectional meters were in place. At the same time, it would be supporting a more inclusive energy transition and reducing the amount of greenhouse gas produced by burning coal to generate power.

    Vehicle-to-grid devices

    My research also found that home solar systems could be integrated with battery electric vehicles using vehicle-to-grid devices. These are systems that allow batteries from electric vehicles to be integrated with electrical devices in a home (fridges, geysers and heaters) and with the national grid. In other words, electric vehicle owners would use their vehicle-to-grid device to sell power to the national grid.

    This would benefit the grid and the vehicle owners, but most importantly would reduce the yearly costs of running an electric vehicle (the combined cost of the electricity the vehicle needs to run, the cost of the vehicle itself and the annual operating costs).

    In practice, this would need electric car owners to charge their cars between 10am and 4pm every day when solar power generation is at its peak. This would mean that the car owners could subsidise their travel costs using “free” excess solar energy.




    Read more:
    Electric vehicles in Africa: what’s needed to grow the sector


    This would be ideal for people who worked from home or used their vehicles for transport to and from work or school in the early morning and late afternoon. Charging stations at workplaces would also achieve this.

    The vehicle battery (typically 40–100 kWh) could then be used by people to power their homes during peak night periods or sell energy back to the grid, while leaving sufficient energy in the battery for the morning travel. Again, this would offset the yearly costs of owning an electric vehicle and boost the national grid by peak shaving.




    Read more:
    Battery swapping stations powered by solar and wind: we show how this could work for electric vehicles in South Africa


    If homeowners managed this well, by generating enough green energy and avoiding the use of energy from the grid, home and vehicle owners should be able to pay no more than they would if they were driving internal combustion engine vehicles that run on petrol, and using electricity from the national power utility, Eskom. In other words, switching to a renewable energy option would be possible without additional cost.

    What needs to happen next

    Net Zero by 2050 is not an aspiration of a small group of environmental activists; it is a legal obligation under South Africa’s Climate Change Act. Despite what climate change denialists may claim, it is not a preferred option – it is the only option.

    Bidirectional meters and vehicle-to-grid charging stations would help the country reach this goal.

    However, the question of who pays for home bidirectional meters, their installation and having them certified has become highly contested. I argue that the state-owned electricity provider, Eskom, and the municipalities should cover the cost of both registration and metering. It shouldn’t be paid by the homeowners.




    Read more:
    Satellite images reveal the dark side of household solar power – South Africa’s green transition is only for a few


    This is because the benefit for electricity distributors is at least five times the cost of the meter itself. Distributors get cheap energy and sell it to other customers. The grid also benefits from having more renewable energy being fed into it.

    Without technology like this, the cost of transitioning to a green energy future remains too high for individual households. But with the technology, the transition becomes economically competitive.

    Continue Reading

  • Anavex Life Sciences to Announce Fiscal 2026 First Quarter Financial Results on Monday, February 9, 2026

    Anavex Life Sciences to Announce Fiscal 2026 First Quarter Financial Results on Monday, February 9, 2026

    By clicking “Continue,” you acknowledge that you are leaving the Anavex Life Sciences website and will be redirected to a third-party website operated by NASDAQ or its affiliates.

    Anavex Life Sciences does not own, control, maintain, or endorse the content on third-party websites and is not responsible for their accuracy, completeness, or reliability. Any information available through this link is provided by third parties and does not represent the views, opinions, forecasts, or predictions of Anavex Life Sciences or its management.

    The linked content is provided for informational purposes only and does not constitute investment advice or an offer to buy or sell securities. Investors should rely on their own independent judgment and consult professional advisors before making any investment decisions.

    Continue Reading

  • Kim, Y. C., Park, C. I., Kim, D. Y., Kim, T. S. & Shin, J. C. Statistical analysis of amputations and trends in Korea. Prosthet. Orthot. Int. 20, 88–95 (1996).

    Google Scholar 

  • Ziegler-Graham, K., MacKenzie, E. J., Ephraim, P. L., Travison, T. G. & Brookmeyer, R. Estimating the prevalence of limb loss in the United States: 2005 to 2050. Arch. Phys. Med. Rehabil. 89, 422–429 (2008).

    Google Scholar 

  • Waters, R. L., Perry, J., Antonelli, D. & Hislop, H. J. Energy cost of walking of amputees: the influence of level of amputation. The journal of bone and joint surgery. American ume 58, 42–46 (1976).

    Google Scholar 

  • Raspopovic, S., Valle, G. & Petrini, F. M. Sensory feedback for limb prostheses in amputees. Nat. Mater. 1–15 https://doi.org/10.1038/s41563-021-00966-9 (2021).

  • Johansson, J. L., Sherrill, D. M., Riley, P. O., Bonato, P. & Herr, H. A clinical comparison of variable-damping and mechanically passive prosthetic knee devices. Am. J. Phys. Med. Rehabil. 84, 563 (2005).

    Google Scholar 

  • Cimolato, A. et al. EMG-driven control in lower limb prostheses: a topic-based systematic review. J. Neuroeng. Rehabil. 19, 43 (2022).

    Google Scholar 

  • Hefferman, G. M., Zhang, F., Nunnery, M. J. & Huang, H. Integration of surface electromyographic sensors with the transfemoral amputee socket: a comparison of four differing configurations. Prosthet. Orthot. Int. 39, 166–173 (2015).

    Google Scholar 

  • Grison, A. et al. Multidimensional motoneuron control using intramuscular microelectrode arrays in tetraplegic spinal cord injury. Preprint at https://doi.org/10.1101/2025.07.17.25331429 (2025).

  • Pasquina, P. F. et al. First-in-man demonstration of a fully implanted myoelectric sensors system to control an advanced electromechanical prosthetic hand. J. Neurosci. Methods 244, 85–93 (2015).

    Google Scholar 

  • Ferrante, L. et al. Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves. Nat. Biomed. Eng 1–16 https://doi.org/10.1038/s41551-025-01537-y (2025).

  • Shu, T., Herrera-Arcos, G., Taylor, C. R. & Herr, H. M. Mechanoneural interfaces for bionic integration. Nat. Rev. Bioeng. 2, 374–391 (2024).

    Google Scholar 

  • Vu, P. P. et al. A regenerative peripheral nerve interface allows real-time control of an artificial hand in upper limb amputees. Sci. Transl. Med. 12, eaay2857 (2020).

  • Kuiken, T. A. et al. Targeted muscle reinnervation for real-time myoelectric control of multifunction artificial arms. JAMA 301, 619–628 (2009).

    Google Scholar 

  • Ortiz-Catalan, M., Mastinu, E., Sassu, P., Aszmann, O. & Brånemark, R. Self-contained neuromusculoskeletal arm prostheses. N. Engl. J. Med. 382, 1732–1738 (2020).

    Google Scholar 

  • Hargrove, L. J. et al. Robotic leg control with EMG decoding in an amputee with nerve transfers. N. Engl. J. Med. 369, 1237–1242 (2013).

    Google Scholar 

  • Clites, T. R. et al. Proprioception from a neurally controlled lower-extremity prosthesis. Sci. Transl. Med. 10, eaap8373 (2018).

    Google Scholar 

  • Song, H. et al. Continuous neural control of a bionic limb restores biomimetic gait after amputation. Nat. Med. 30, 2010–2019 (2024).

    Google Scholar 

  • Shu, T. et al. Tissue-integrated bionic knee restores versatile legged movement after amputation. Science 389, eadv3223 (2025).

    Google Scholar 

  • Srinivasan, S. S. et al. Agonist-antagonist myoneural interface amputation preserves proprioceptive sensorimotor neurophysiology in lower limbs. Sci. Transl. Med. 12, eabc5926 (2020).

    Google Scholar 

  • Perry, S. D., McIlroy, W. E. & Maki, B. E. The role of plantar cutaneous mechanoreceptors in the control of compensatory stepping reactions evoked by unpredictable, multi-directional perturbation. Brain Res. 877, 401–406 (2000).

    Google Scholar 

  • Roll, R., Kavounoudias, A. & Roll, J.-P. Cutaneous afferents from human plantar sole contribute to body posture awareness. Neuroreport 13, 1957–1961 (2002).

    Google Scholar 

  • Kim, D., Triolo, R. & Charkhkar, H. Plantar somatosensory restoration enhances gait, speed perception, and motor adaptation. Sci. Robot. 8, eadf8997 (2023).

    Google Scholar 

  • Charkhkar, H., Christie, B. P. & Triolo, R. J. Sensory neuroprosthesis improves postural stability during sensory organization test in lower-limb amputees. Sci. Rep. 10, 6984 (2020).

    Google Scholar 

  • Petrini, F. M. et al. Sensory feedback restoration in leg amputees improves walking speed, metabolic cost and phantom pain. Nat. Med. 25, 1356–1363 (2019).

    Google Scholar 

  • Petrini, F. M. et al. Enhancing functional abilities and cognitive integration of the lower limb prosthesis. Sci. Transl. Med. 11, eaav8939 (2019).

    Google Scholar 

  • Valle, G. et al. Mechanisms of neuro-robotic prosthesis operation in leg amputees. Sci. Adv. 7, eabd8354 (2021).

    Google Scholar 

  • Preatoni, G., Valle, G., Petrini, F. M. & Raspopovic, S. Lightening the perceived weight of a prosthesis with cognitively integrated neural sensory feedback. Curr. Biol. 31, 1–7 (2021).

    Google Scholar 

  • Valle, G. et al. Biomimetic computer-to-brain communication enhancing naturalistic touch sensations via peripheral nerve stimulation. Nat. Commun. 15, 1151 (2024).

    Google Scholar 

  • Davis, T. S. et al. Restoring motor control and sensory feedback in people with upper extremity amputations using arrays of 96 microelectrodes implanted in the median and ulnar nerves. J. Neural Eng. 13, 036001 (2016).

    Google Scholar 

  • Petrini, F. M. et al. Microneurography as a tool to develop decoding algorithms for peripheral neuro-controlled hand prostheses. Biomed. Eng. Online 18, 44 (2019).

    Google Scholar 

  • Cracchiolo, M. et al. Computational approaches to decode grasping force and velocity level in upper-limb amputee from intraneural peripheral signals. J. Neural Eng. 18, 055001 (2021).

  • Cracchiolo, M. et al. Decoding of grasping tasks from intraneural recordings in trans-radial amputee. J. Neural Eng. https://doi.org/10.1088/1741-2552/ab8277 (2020).

  • Wendelken, S. et al. Restoration of motor control and proprioceptive and cutaneous sensation in humans with prior upper-limb amputation via multiple Utah slanted electrode arrays (USEAs) implanted in residual peripheral arm nerves. J. Neuroeng. Rehabil. 14, 121 (2017).

  • Donati, E. & Indiveri, G. Neuromorphic bioelectronic medicine for nervous system interfaces: from neural computational primitives to medical applications. Prog. Biomed. Eng. 5, 013002 (2023).

    Google Scholar 

  • Donati, E. & Valle, G. Neuromorphic hardware for somatosensory neuroprostheses. Nat. Commun. 15, 556 (2024).

    Google Scholar 

  • Pillastrini, P., Marchetti, M. & Abbruzzese, G. Neurofisiologia del movimento. Anatomia, biomeccanica, chinesiologia, clinica, 2nd edn (Piccin-Nuova Libraria, Padova, 2020).

  • Rigoard, P. Atlas of Anatomy of the Peripheral Nerves: The Nerves of the Limbs–Expert Edition (Springer International Publishing, 2020).

  • Herdin, M., Czink, N., Ozcelik, H. & Bonek, E. Correlation matrix distance, a meaningful measure for evaluation of non-stationary MIMO channels. In Proc. 2005 IEEE 61st Vehicular Technology Conference Vol. 1, 136–140 (IEEE, 2005).

  • Yavuz, U. Ş, Negro, F., Diedrichs, R. & Farina, D. Reciprocal inhibition between motor neurons of the tibialis anterior and triceps surae in humans. J. Neurophysiol. 119, 1699–1706 (2018).

    Google Scholar 

  • Bian, S., Donati, E. & Magno, M. Evaluation of encoding schemes on ubiquitous sensor signal for spiking neural network. IEEE Sens. J. 24, 35008–35018 (2024).

    Google Scholar 

  • Sava, R., Donati, E. & Indiveri, G. Feed-forward and recurrent inhibition for compressing and classifying high dynamic range biosignals in spiking neural network architectures. In Proc. IEEE Biomedical Circuits and Systems Conference (BioCAS) 1–5, https://doi.org/10.1109/BioCAS58349.2023.10388963 (2023).

  • Hong, K.-S., Aziz, N. & Ghafoor, U. Motor-commands decoding using peripheral nerve signals: a review. J. Neural Eng. 15, 031004 (2018).

    Google Scholar 

  • Goncharova, I. I., McFarland, D. J., Vaughan, T. M. & Wolpaw, J. R. EMG contamination of EEG: spectral and topographical characteristics. Clin. Neurophysiol. 114, 1580–1593 (2003).

    Google Scholar 

  • Schone, H. R. et al. Stable cortical body maps before and after arm amputation. Nat Neurosci 28, 2015–2021 (2025).

  • Raspopovic, S., Petrini, F. M., Zelechowski, M. & Valle, G. Framework for the development of neuroprostheses: from basic understanding by sciatic and median nerves models to bionic legs and hands. Proc. IEEE 105, 34–49 (2017).

    Google Scholar 

  • Zelechowski, M., Valle, G. & Raspopovic, S. A computational model to design neural interfaces for lower-limb sensory neuroprostheses. J. Neuroeng. Rehabil. 17, 24 (2020).

    Google Scholar 

  • Warchoł, Ł, Walocha, J. A., Mizia, E., Liszka, H. & Bonczar, M. Comparison of the histological structure of the tibial nerve and its terminal branches in the fresh and fresh-frozen cadavers. Folia Morphol. 80, 542–548 (2021).

    Google Scholar 

  • Jankowska, E. & Roberts, W. J. Synaptic actions of single interneurones mediating reciprocal Ia inhibition of motoneurones. J. Physiol. 222, 623–642 (1972).

    Google Scholar 

  • Shindo, M., Harayama, H., Kondo, K., Yanagisawa, N. & Tanaka, R. Changes in reciprocal Ia inhibition during voluntary contraction in man. Exp. Brain Res. 53, 400–408 (1984).

    Google Scholar 

  • De Luca, C. J. & Mambrito, B. Voluntary control of motor units in human antagonist muscles: coactivation and reciprocal activation. J. Neurophysiol. 58, 525–542 (1987).

    Google Scholar 

  • Dietz, V. & Sinkjaer, T. Spastic movement disorder: impaired reflex function and altered muscle mechanics. Lancet Neurol. 6, 725–733 (2007).

    Google Scholar 

  • Reilly, K. T., Mercier, C., Schieber, M. H. & Sirigu, A. Persistent hand motor commands in the amputees’ brain. Brain 129, 2211–2223 (2006).

    Google Scholar 

  • Enoka, R. M. & Duchateau, J. Rate coding and the control of muscle force. Cold Spring Harb. Perspect. Med. 7, a029702 (2017).

    Google Scholar 

  • Macefield, V. G., Fuglevand, A. J., Howell, J. N. & Bigland-Ritchie, B. Discharge behaviour of single motor units during maximal voluntary contractions of a human toe extensor. J. Physiol. 528, 227–234 (2000).

    Google Scholar 

  • Barberi, F. et al. Early decoding of walking tasks with minimal set of EMG channels. J. Neural Eng. 20, 026038 (2023).

    Google Scholar 

  • De Luca, C., Tincani, M., Indiveri, G. & Donati, E. A neuromorphic multi-scale approach for real-time heart rate and state detection. npj Unconv. Comput. 2, 6 (2025).

    Google Scholar 

  • Baracat, F., Mazzoni, A., Micera, S., Indiveri, G. & Donati, E. Decoding gestures from intraneural recordings of a transradial amputee using event-based processing. Preprint at https://doi.org/10.36227/techrxiv.170719069.94594142/v2 (2024).

  • Katic, N. et al. Modeling foot sole cutaneous afferents: FootSim. iScience 26, 105874 (2023).

    Google Scholar 

  • Delgado-Martínez, I., Badia, J., Pascual-Font, A., Rodríguez-Baeza, A. & Navarro, X. Fascicular topography of the human median nerve for neuroprosthetic surgery. Front. Neurosci. 10, 286 (2016).

  • Dhillon, G. S., Lawrence, S. M., Hutchinson, D. T. & Horch, K. W. Residual function in peripheral nerve stumps of amputees: implications for neural control of artificial limbs. J. Hand Surg. Am. 29, 605–615 (2004).

    Google Scholar 

  • Seyedali, M., Czerniecki, J. M., Morgenroth, D. C. & Hahn, M. E. Co-contraction patterns of trans-tibial amputee ankle and knee musculature during gait. J. Neuroeng. Rehabil. 9, 29 (2012).

    Google Scholar 

  • Valle, G. et al. Multifaceted understanding of human nerve implants to design optimized electrodes for bioelectronics. Biomaterials 291, 121874 (2022).

    Google Scholar 

  • Aiello, G., Valle, G. & Raspopovic, S. Recalibration of neuromodulation parameters in neural implants with adaptive Bayesian optimization. J. Neural Eng. 20, 026037 (2023).

  • Chen, W., Liu, X., Wan, P., Chen, Z. & Chen, Y. Anti-artifacts techniques for neural recording front-ends in closed-loop brain-machine interface ICs. Front. Neurosci. 18, 1393206 (2024).

  • Dosen, S., Schaeffer, M.-C. & Farina, D. Time-division multiplexing for myoelectric closed-loop control using electrotactile feedback. J. Neuroeng. Rehabil. 11, 138 (2014).

    Google Scholar 

  • Chateaux, M. et al. New insights into muscle activity associated with phantom hand movements in transhumeral amputees. Front. Hum. Neurosci. 18, 1443833(2024).

  • Jarrassé, N. et al. Phantom-mobility-based prosthesis control in transhumeral amputees without surgical reinnervation: a preliminary study. Front. Bioeng. Biotechnol. 6, 164 (2018).

    Google Scholar 

  • Čvančara, P. et al. Bringing sensation to prosthetic hands—chronic assessment of implanted thin-film electrodes in humans. npj Flex. Electron. 7, 1–14 (2023).

    Google Scholar 

  • Rey, H. G., Pedreira, C. & Quian Quiroga, R. Past, present and future of spike sorting techniques. Brain Res. Bull. 119, 106–117 (2015).

    Google Scholar 

  • Stimberg, M., Brette, R. & Goodman, D. F. Brian 2, an intuitive and efficient neural simulator. eLife 8, e47314 (2019).

    Google Scholar 

  • van Schaik, A., Fragniere, E. & Vittoz, E. An analogue electronic model of ventral cochlear nucleus neurons. In Proc. of Fifth International Conference on Microelectronics for Neural Networks 52–59, https://doi.org/10.1109/MNNFS.1996.493772 (1996).

  • Zanghieri, M., Benatti, S., Benini, L. & Donati, E. Event-based low-power and low-latency regression method for hand kinematics from surface EMG. In Proc. 9th International Workshop on Advances in Sensors and Interfaces (IWASI) 293–298, https://doi.org/10.1109/IWASI58316.2023.10164372 (2023).

  • Eshraghian, J. K. et al. Training spiking neural networks using lessons from deep learning. Proc. IEEE 111, 1016–1054 (2023).

    Google Scholar 

  • Neftci, E. O., Mostafa, H. & Zenke, F. Surrogate Gradient Learning in Spiking Neural Networks: Bringing the Power of Gradient-Based Optimization to Spiking Neural Networks. IEEE Signal Processing Magazine 36, 51–63 (2019).

  • Valle, G. et al. A psychometric platform to collect somatosensory sensations for neuroprosthetic use. Front. Med. Technol. 3, 8 (2021).

    Google Scholar 

Continue Reading

  • One Generation Runs the Country. The Next Cashed In on Crypto. – The Wall Street Journal

    1. One Generation Runs the Country. The Next Cashed In on Crypto.  The Wall Street Journal
    2. Trump claims “I have helped cryptocurrency more than anyone,” while investors have poured $31.2 million into the bitcoin market.  Bitget
    3. Πληροφορίες από HASNAIN NADEEM 786(@HASNAINNADEM)  Binance
    4. Why Trump-Linked Crypto Stocks And Tokens Are Back On Traders’ Radar  Stocktwits
    5. One generation runs the country. The next cashed in on crypto  MSN

    Continue Reading

  • Assessing ERAMET (ENXTPA:ERA) Valuation After Recent Share Price Momentum And DCF Upside Potential

    Assessing ERAMET (ENXTPA:ERA) Valuation After Recent Share Price Momentum And DCF Upside Potential

    Track your investments for FREE with Simply Wall St, the portfolio command center trusted by over 7 million individual investors worldwide.

    ERAMET (ENXTPA:ERA) has recently drawn investor attention after a period where the share price showed mixed short term moves, followed by a strong gain over the past 3 months. This has prompted a closer look at fundamentals.

    See our latest analysis for ERAMET.

    At a share price of €68.05, ERAMET has seen a 28.4% 90 day share price return and a 23.6% 1 year total shareholder return, while the 3 year total shareholder return remains negative. This indicates that recent momentum looks stronger than the longer term picture.

    If ERAMET’s recent move has you thinking about other materials names, you might like our screener of 28 best rare earth metal stocks as a starting point for further ideas.

    With ERAMET trading at €68.05 and sitting above the average analyst price target, yet flagged with a large estimated intrinsic discount, you have to ask if the market is missing something or already pricing in better days ahead?

    On the pricing side, ERAMET’s last close of €68.05 lines up with a P/S of 0.7x, which screens as inexpensive against both peers and the wider European metals and mining group.

    The P/S ratio compares the company’s market value to its revenue, so a 0.7x multiple means investors are paying €0.70 for every €1 of annual sales. For a business generating €2,915.0m of revenue but currently reporting a net loss of €97.0m, using sales instead of earnings can be a practical way to benchmark valuation while profitability remains weak.

    According to Simply Wall St’s checks, ERAMET looks good value on several fronts: its 0.7x P/S is in line with the peer average of 0.7x, sits below the European metals and mining industry average of 1.1x, and is also well below an estimated fair P/S of 3.8x that their model suggests the market could move towards if sentiment and fundamentals aligned.

    Explore the SWS fair ratio for ERAMET

    In addition, our DCF model currently estimates ERAMET’s future cash flow value at €413.52 per share, compared with the current €68.05 share price. The SWS DCF model projects future cash flows and discounts them back to today using an appropriate rate, which can sometimes result in very large intrinsic value gaps for companies where expectations for future cash generation differ from what the market is currently pricing.

    For ERAMET, which is still loss making but has forecasts pointing to earnings growth and an expected return on equity of 5.8% in three years, a cash flow based approach puts more weight on the path back to profitability than on today’s income statement. That can lead to a very different view compared with simple multiples.

    Look into how the SWS DCF model arrives at its fair value.

    Result: Price-to-Sales ratio of 0.7x (UNDERVALUED)

    However, ERAMET is still reporting a €97.0m loss and operates in cyclical manganese and nickel markets. Weaker pricing or project setbacks could quickly challenge this valuation gap.

    Find out about the key risks to this ERAMET narrative.

    While the 0.7x P/S suggests ERAMET looks inexpensive, our DCF model goes much further, putting future cash flow value at €413.52 per share versus today’s €68.05 price. That is a very large gap, so you have to ask whether the cash flow assumptions or the market are off the mark.

    Look into how the SWS DCF model arrives at its fair value.

    ERA Discounted Cash Flow as at Feb 2026

    Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out ERAMET for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover 237 high quality undervalued stocks. If you save a screener we even alert you when new companies match – so you never miss a potential opportunity.

    If you look at the numbers and reach a different conclusion, or simply prefer to test your own view against the data, you can build a personalised thesis in just a few minutes, starting with Do it your way.

    A great starting point for your ERAMET research is our analysis highlighting 3 key rewards and 3 important warning signs that could impact your investment decision.

    If you want to stress test your view on ERAMET and keep your watchlist fresh, use the screeners below to spot opportunities you might otherwise miss.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include ERA.PA.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading

  • China’s aluminium smelters embark on green long march

    China’s aluminium smelters embark on green long march

    China’s aluminium industry has embarked on a green long march, moving millions of tonnes of production from the northern coal country, its stronghold for seven decades, to pockets of the south and west rich in renewable energy.

    The country’s output of electrolytic aluminium, the sector’s main product, reached 43.8mn tonnes in 2024, accounting for about 60 per cent of the world’s total production, according to local industry data.

    However, following a spree of relocations in recent years, 13mn tonnes of that capacity — about 30 per cent — now comes from new smelters in areas with clean energy and low-development costs in Yunnan, Sichuan, Xinjiang and Inner Mongolia.

    The years-long multibillion-dollar relocation project is helping decarbonise one of the world’s dirtiest industries. Analysts believe the aluminium sector’s success will serve as a blueprint for Beijing to direct more aggressive production caps and capacity swapping in other industries.

    “In China, there is always this trial system: you start from a city or province and, if it is successful, you ramp it up at a national level, and sectors are also the same,” said Isadora Wang, head of China at energy think-tank Transition Asia.

    “The aluminium sector has been the most successful in implementing this capacity swap policy, but if it is proven to be useful, to be effective, then different sectors with some similarities will use it.”

    A hydropower station in Yunnan, where many Chinese aluminium smelters have relocated © Yang Zheng/VCG via Getty Images

    Change has gathered pace since 2017, when China’s government set an annual domestic production cap of 45.5mn tonnes. The following year Beijing prohibited new smelting capacity in parts of the country already subject to strict air pollution prevention measures. And in 2020, President Xi Jinping set a goal for China to reach peak CO₂ emissions by 2030 and net zero emissions by 2060.

    Taken together, these rules mean that companies building new smelters in the south and west also have to decommission an equivalent capacity in their traditional northern hubs, where they are dependent on coal-fired electricity.

    Today, beneath clear skies in the south-western province of Yunnan, the future of an industry that has historically contributed to 5 per cent of China’s carbon emissions is coming into view.

    Spanning several square kilometres, the industrial park in the small city of Wenshan houses new energy-hungry smelters producing alloys crucial for everything from ships and smartphones to electric vehicles and high-speed trains.

    Nearby is a vast web of high-voltage lines delivering electricity from the region’s hydropower stations. The surrounding hills are either clad with solar panels or topped with wind turbines.

    “China’s aluminium industry is undergoing a profound and systematic transformation,” Le Jiawen, Wenshan’s mayor, told local industry members at an event attended by the FT.

    “Industrial competition is shifting from a battle of scale and cost to a comprehensive contest of ‘green’ and ‘low-carbon’ advantages.”

    Plans have been drawn up for a new rail line to be constructed by about 2030, connecting the industrial zone to customers in China and neighbouring Vietnam and Laos, officials said.

    Some content could not load. Check your internet connection or browser settings.

    China Hongqiao, the country’s biggest private-sector aluminium group by production volume, expects to finish its second smelter in Wenshan this year. When complete, its Yunnan operations will account for 4mn tonnes of annual capacity, just over 60 per cent of its total and equivalent to the US’s entire aluminium output.

    Hongqiao, based in north-eastern Shandong, did not provide specific investment figures for the Yunnan relocation. However, according to company filings, the budget for its two new smelters was a combined Rmb45.6bn ($6.5bn).

    A corporate presentation stated the relocation, paired with investments in solar and wind production in Shandong and Yunnan, would slash about two-thirds of the company’s carbon emissions.

    Further impetus for the relocations has come from environmental policies in Brussels. The EU’s carbon border adjustment mechanism means future imports of products such as steel, aluminium, cement and fertilisers face a carbon levy.

    Within China, the relocation policy has raised questions about the viability of northern rust-belt regions, which risk being left behind by the green transition. Hongqiao said it would boost development and production of lower-volume, higher-value products in Shandong.

    Environmentalists are also concerned that investments by some Chinese groups in Indonesia to secure bauxite-based materials — a key feedstock for aluminium in which China lacks supply — are underpinning coal-fired electricity growth in the south-east Asian nation.

    Analysts from Dutch bank ING noted in December that China’s aluminium output was close to its self-imposed 45mn-tonne cap, keeping global prices high and prompting Chinese companies to expand capacity overseas.

    US-based Human Rights Watch also highlighted in a 2024 report how an increasing proportion of aluminium being produced in Xinjiang raised the risk of multinational companies’ supply chains being implicated in Beijing’s long-running campaign of repression in the region.

    A worker operates machinery to move large rolls of aluminium material between rows of metal coils in a factory workshop.
    Aluminium materials in use at a Hangzhou workshop. It is claimed China now boasts the world’s only ‘complete’ aluminium ecosystem, including more than 20 industry clusters nationwide © Costfoto/Future Publishing via Getty Images

    The decarbonisation strategy has sparked aggressive competition between China’s cash-strapped local governments, each aggressively vying for investments.

    Official promotional material from Inner Mongolia and Yunnan, reviewed by the FT, shows governments offering policy support including tax breaks, research and development subsidies, and cheap electricity, water, gas and land.

    The low power prices in particular are an “important consideration” for companies as they choose new locations, said Shen Xinyi, who leads the China team for the Centre for Research on Energy and Clean Air, a European think-tank.

    In a presentation to industry members in December, Fan Shunke, deputy secretary of the Communist Party committee for the China Nonferrous Metals Industry Association, said the relocation strategy and production caps meant emissions from China’s aluminium industry had peaked in 2024.

    He touted that China now boasted the world’s only “complete” aluminium ecosystem, pointing to more than 20 industry clusters nationwide that included not only smelters but also facilities for producing bauxite and prebaked carbon anodes.

    “The US does not have this, Europe is even less capable and the Middle East wants to build one,” said Fan.

    Additional contributions by Wenjie Ding in Wenshan

    Continue Reading

  • Is India about to make Ozempic-like weight-loss drugs a whole lot cheaper?

    Is India about to make Ozempic-like weight-loss drugs a whole lot cheaper?


    Mumbai, India
     — 

    On any given morning in Mumbai’s Shivaji Park, power-walkers circle the running track, fitness watches buzzing with every step. Minutes later, some drift toward nearby food stalls, where oil sizzles and hot samosas and syrupy jalebis land on paper plates. It’s a snapshot of India’s uneasy relationship with health and indulgence – and the backdrop to a fast-growing medical and commercial frenzy.

    That frenzy is over the imminent expiry of a patent protecting semaglutide, a protein that mimics a hormone telling your brain that you’re not hungry. It’s a key ingredient in Novo Nordisk’s wildly popular injectable weight-loss drug Ozempic.

    Novo Nordisk’s India patent will expire in March. And the country’s colossal pharma production industry is gearing up to take advantage by selling generic versions.

    Analysts there predict a price war that could drive the cost of some weight-loss drugs down by as much as 90 percent in India – and possibly in other countries too. Jefferies, the investment bank, describes it as a “magic pill moment” for India, projecting that the semaglutide market could grow to $1 billion.

    “We are fully prepared and geared up,” Namit Joshi, chairman of the government’s Pharmaceuticals Export Promotion Council of India (Pharmexcil), told CNN. “There will be a bombardment of this product the moment the patent expires.”

    Just as India – known as the “pharmacy of the world” – helped make HIV drugs cheaper and more widely available decades ago, analysts say it could become the key, low-cost supplier of a new global health revolution against obesity.

    The shift could also be transformative for India, currently the world’s diabetes capital and among the fastest-growing markets on the planet for anti-obesity treatments and drugs. By 2050, 450 million adults in India are projected to be overweight, according to an estimate in medical journal The Lancet.

    Semaglutide mimics a hormone that regulates appetite and blood sugar – essentially, it tells your brain you’re full. It’s the core part of popular commercially available anti-obesity drugs like Ozempic, which is often sold pre-loaded into a syringe that patients self-inject with.

    It’s a method India’s pharma giants are confident they can replicate, come March.

    At least 10 Indian firms, including Dr. Reddy’s Laboratories, Cipla, and OneSource Specialty Pharma have started processes to manufacture semaglutide weight-loss drugs, according to documents reviewed by CNN.

    OneSource says it is investing nearly $100 million as part of plans to ramp up production capacity by five times over the next 18 to 24 months, particularly for drug-device combination products – things like syringes prepped with weight-loss drugs, including semaglutide.

    Another Indian company, Biocon, told CNN it has commissioned an injectables facility in the city of Bengaluru, designed to serve both domestic and international markets, with a total investment of around $100 million.

    The firm is hoping to launch the products in 2027, CEO Siddharth Mittal added, and has plans to export to Brazil and Canada.

    Rival firm Dr. Reddy’s told Reuters it plans to launch the generic version of semaglutide in 87 countries, including India, next year. Its CEO Erez Israeli said he expects the generic drug to generate “hundreds of millions of dollars” in sales for the company.

    Pharmexcil’s Joshi believes the average price of a monthly dose in India could fall to $77 within a year after the patent’s expiry, and eventually to around $40.

    That kind of pricing wont be seen on US shelves anytime soon – Ozempic’s US patent doesn’t expire until the 2030s.

    At 70 years old, Mahesh Chamadia had almost given up on the idea of losing weight. The Mumbai accountant wakes at 4:30 a.m. for badminton, keeps a treadmill at home, and has tried gyms, diets, and yoga. But the weight always came back. After 25 years of trying, he needed to find a solution, and fast. “I did not want to carry this heavy weight as I got older and older,” he told CNN.

    Then, in 2024 Chamadia started reading about a new class of injectable drugs making headlines abroad. Every week, he scoured the papers for updates. At his checkups, he would quiz his doctor: When are they coming to India?

    By March 2025, when Eli Lilly’s tirzepatide (sold under the brand name Mounjaro) hit Indian pharmacies, he was first in line. “I told my doctor, I want to try it,” he recalls.

    Nine months later, he’s 10 kilograms (22 pounds) lighter – more than he’s lost in decades. His blood sugar sometimes dips to 100, the unicorn number for diabetics, something he says has “never happened in his history of 25 years of diabetes.”

    Vials of Mounjaro, a tirzepatide injection drug used for treating type 2 diabetes and weight loss, are seen in a fridge at a health clinic in Hyderabad, India, on April 14, 2025.

    His triglycerides – the most common type of body fat – fell for the first time, his energy surged, and even his cravings reduced. “Every Sunday for 25 years I brought samosas home after badminton. Now I don’t. My cravings have become negligible.”

    According to research firm Pharmarack, Mounjaro has quickly risen to become India’s second-largest pharmaceutical brand in September 2025 – just six months after its launch. A boom in weight-loss drug sales has transformed Eli Lilly into a Wall Street heavyweight, its stock up more than 35% this year and its market value recently crossing $1 trillion.

    The medicine doesn’t come cheap. Chamadia says he spends around 25,000 Indian rupees ($280) per month on his injections – more than the salary of many workers.

    “Yes, it is expensive,” he says, “but it doesn’t matter too much. My insulin doses have come down, some of my other diabetes medicines have reduced.”

    These drugs are not without risks. According to the website of Wegovy, another popular brand, the most common side effects include nausea, diarrhea, vomiting, constipation, abdominal pain, and headaches.

    And in a country where Bollywood stars and social media influencers heavily shape body image, doctors worry the drugs could be misused.

    Some clinics have already started advertising these injections as part of pre-wedding crash slimming programs to help brides or grooms get into shape quickly for their big day.

    “Whenever you have a surge in demand, especially with weight-loss drugs, there is bound to be misuse,” obesity specialist Dr. Rajiv Kovil told CNN.

    “These are not meant for cosmetic slimming before a wedding or a party,” he cautioned.

    “The management of obesity comes as a package; semaglutide is just one tool,” said Dr. Atul Luthra, endocrinologist at Fortis Hospital, near the capital New Delhi.

    “Regular physical activity and a proper diet not only improve the efficacy of semaglutide but also help with its tolerability. If people don’t follow the required dietary precautions, they will experience more stomach and intestine-related side effects.”

    Back in his doctor’s office, Chamadia scrolls on his phone, scanning news alerts about the soon-to-launch higher-dose injection pens. “It should have arrived in India by now,” he says, glancing at the doctor. For him, each delivery is more than a prescription refill – it’s a measure of progress, of finally gaining control over his health.

    Doctors, meanwhile, are bracing for a flood of new patients seeking the injections – some, like Chamadia, who medically qualify, and others drawn by the lure of a quick fix.

    For doctors and policymakers, the countdown will carry a different urgency: whether this new era of weight-loss drugs can meaningfully tackle an obesity epidemic projected to engulf nearly half a billion Indians, or whether it will leave the country chasing a solution in a syringe while ignoring the harder work of changing diets and lifestyles.

    Chamadia, for one, is convinced. He is already urging his 38-year-old son, who is also struggling with obesity and diabetes, to join him in injecting appetite-suppressing drugs.

    “This is not only about weight loss,” Chamadia insists. “It is about controlling everything else – sugar, fatty liver, lipids.”

    Continue Reading