Category: 3. Business

  • Alaska News Nightly: Tuesday, December 23, 2025

    Alaska News Nightly: Tuesday, December 23, 2025

    Tuesday on Alaska News Nightly

    State lawmakers weigh in on next month’s legislative session. We discuss what to expect. Plus, Fairbanks residents can expect a White Christmas, followed by some very intense cold. And, Juneau residents hit the slopes this week to celebrate the solstice.

    Reports tonight from:

    Eric Stone, Jamie Diep and Alix Soliman in Juneau,
    Desiree Hagen in Kotzebue,
    Tim Ellis in Delta Junction,
    Sofia Stuart-Rasi in Unalaska.

    This episode of Alaska News Nightly is hosted by Wesley Early with audio engineering from Crystal Hyde and producing by Madilyn Rose.

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  • An Indirect VAT Compliance Gap Estimation Technique

    An Indirect VAT Compliance Gap Estimation Technique

    Summary

    This technical note presents the Reverse Method, a novel indirect approach for estimating the global value-added tax (VAT) compliance gap. The Reverse Method leverages public datasets and a calibrated econometric model to produce scalable, comparable, and indicative VAT gap estimates for over 100 countries and multiple years. It builds on the IMF’s RA-GAP (Revenue Administration Gap Analysis Program) framework, using C-efficiency, tax expenditure data, and national accounts to approximate the compliance gap as a residual. The methodology enables broad cross-country analysis, supports tax gap benchmarking, and provides indicative estimates even where detailed data is scarce. While not a substitute for country-specific RA-GAP assessments, the Reverse Method offers a practical tool for monitoring global VAT compliance trends, informing tax gap analysis, and facilitating international comparisons. Its results highlight differences by income level and region, and the approach is designed for continuous improvement as more data becomes available.

    Subject: Revenue administration, Revenue Administration Gap Analysis Program (RA-GAP), Revenue performance assessment, Tax efficiency, Tax gap, Taxes, Value added tax

    Keywords: Asia and Pacific, Central Asia, Europe, Middle East, Middle East and Central Asia, Revenue Administration Gap Analysis Program (RA-GAP), Tax efficiency, Tax gap, Value-added tax, Western Hemisphere

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  • Access Denied


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    You don’t have permission to access “http://www.spglobal.com/energy/en/news-research/latest-news/agriculture/122325-indonesia-keeps-2026-biodiesel-quota-flat-raising-doubts-over-b50-target” on this server.

    Reference #18.daa0d517.1766544587.a6944549

    https://errors.edgesuite.net/18.daa0d517.1766544587.a6944549

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  • UNL report estimates nearly $3.3 billion in annual economic losses from Tyson Foods closure

    UNL report estimates nearly $3.3 billion in annual economic losses from Tyson Foods closure

    An economic impact analysis estimates that Nebraska will face nearly $3.3 billion in annual economic losses due to the closure of the Tyson Foods beef processing plant in Lexington.

    The analysis, released Monday by the University of Nebraska-Lincoln’s Center for Agricultural Profitability, was completed using a statistical model that takes into account both direct impacts, like job losses and tax revenue decreases, and second-order impacts like potential job losses in related sectors and decreased spending within a community.

    It found that the closure will result in about $530 million in lost income – both from the 3,200 Tyson workers who will be laid off when the plant closes in January, and from thousands of jobs in related sectors. Some job losses in other sectors have already been seen: Fortrex, a sanitation contractor for Tyson, announced shortly after Tyson’s announcement that it would lay off 139 workers.

    Both state and local tax revenues are likely to take a big hit, according to the report. State annual losses are estimated at $23.2 million for income tax and $10.1 million in sales tax. Local sales tax revenue in Dawson County is expected to fall by $2.7 million annually.

    While the economic impacts will be felt statewide, the report said, they will be concentrated in Dawson County and surrounding areas.

    To complete the analysis, researchers estimated that about 85% of the cattle slaughtered at the Tyson plant came from Nebraska feedlots. They also estimated that the average employee spent about 35% of their income on goods and services subject to state sales tax.

    The closure comes amid significant economic issues in the cattle industry. In 2025, the U.S. recorded its smallest beef cattle herd in more than 70 years, and meatpackers are losing money as they operate well below capacity. Tyson is the first of the “big four” meatpackers – Cargill, National Foods, JBS and Tyson – to close a major facility during the current supply crunch.

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  • Gold Soars Above $4,500 for First Time on Geopolitics, Rates – Bloomberg.com

    1. Gold Soars Above $4,500 for First Time on Geopolitics, Rates  Bloomberg.com
    2. Gold, silver and platinum sparkle at all-time peaks  Reuters
    3. Gold hits record high on US rate cut bets; silver joins rally to hit all-time peak  Dawn
    4. Gold and silver hit records as investors hunt for safety  BBC
    5. Gold tops $4,500, Japan stabilizes, U.S. data in focus— what’s moving markets  Investing.com

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  • Hyundai Motor Group Strengthens Software and IT Leadership with Key Executive Appointments

    Hyundai Motor Group Strengthens Software and IT Leadership with Key Executive Appointments

    Seokmoon Ryoo, Senior Vice President and Head of Software Platform Division at Hyundai AutoEver, has been appointed as CEO of the software focused Hyundai affiliate, effective January 1st, 2026. This move aligns with the Group’s strategy of enhancing its technological and quality driven edge in software development.

    Ryoo joined Hyundai AutoEver in 2024 after serving as CTO at SOCAR, Korea’s mobility innovation platform. During his tenure at Hyundai AutoEver, he led the development of IT systems, software platforms, and vehicle software innovation initiatives.

    Under his leadership, Hyundai AutoEver fostered a culture of innovation and talent cultivation in software development. As CEO, Ryoo’s mandate includes strengthening technological and quality excellence while driving greater synergies in Group-wide software innovation.

    These leadership changes solidify Hyundai Motor Group’s commitment to technology-driven management and its transition into a software-defined mobility group. The Group continues to make strategic investments to ensure long-term technological competitiveness and sustain its innovation momentum.


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  • The University of Tokyo and Fujitsu launch trial for Japan’s first cloud-connected inter-regional workload shift based on power grid conditions

    The University of Tokyo and Fujitsu launch trial for Japan’s first cloud-connected inter-regional workload shift based on power grid conditions

    The University of Tokyo (UTokyo) and Fujitsu Limited today announced the commencement of a trial on inter-regional workload shifting between data centers. This initiative is part of the Watt-Bit Collaboration Project, which aims to optimize electricity supply and demand by integrating and operating power and communication systems in response to the increasing power consumption of data centers driven by AI demand. The trial will run from January 5, 2026, to March 31, 2026.

    This trial is a technical verification toward the realization of the Watt-Bit Collaboration Project for Green Transformation, which the UTokyo announced with TEPCO Power Grid in October 2025. Moving forward, the partners aim to build a carbon-neutral and sustainable infrastructure and contribute to green transformation by actively utilizing renewable energy to meet electricity demand.

    The two organizations will collaborate with national and related bodies to expand connected locations and plan additional verifications, including the utilization of APN (All Photonics Network), the next-generation communication infrastructure. Through open innovation and collaboration across industry, government, and academia, the organizations will develop technologies to realize a sovereign distributed data center concept ensuring data and operational sovereignty primarily in regions surrounding renewable energy sources, thereby contributing to the development of sustainable public infrastructure.

    UTokyo’s Center for Strategic Promotion of Green Transformation (GX) has previously promoted the introduction of renewable energy, the spatial and temporal understanding of electricity consumption, and conducted trials on workload shifting based on electricity price differences between regions. In addition to these efforts, UTokyo will proceed with the integrated visualization of campus-wide electricity consumption and carbon footprint, the utilization of energy data such as from power grids, and the optimization of electricity consumption within the campus across facilities and equipment, including workload shifting, and further utilization of renewable energy.

    Fujitsu aims to advance the social implementation of the Watt-Bit Collaboration and make the world more sustainable by providing the sovereign cloud solution Fujitsu Cloud Service powered by Oracle Alloy and cloud-native technologies including containers, which are essential for distributed data centers.

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  • Monroe SM, Harkness KL. Major depression and its recurrences: life course matters. Annu Rev Clin Psychol. 2022;18:329–57.

    Article 
    PubMed 

    Google Scholar 

  • Ferrari AJ, Baxter AJ, Whiteford HA. A systematic review of the global distribution and availability of prevalence data for bipolar disorder. J Affect Disord. 2011;134:1–13.

    Article 
    PubMed 

    Google Scholar 

  • Sanacora G, Zarate CA, Krystal JH, Manji HK. Targeting the glutamatergic system to develop novel, improved therapeutics for mood disorders. Nat Rev Drug Discov. 2008;7:426–37.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Niciu MJ, Kelmendi B, Sanacora G. Overview of glutamatergic neurotransmission in the nervous system. Pharmacol Biochem Behav. 2012;100:656–64.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Popoli M, Yan Z, McEwen BS, Sanacora G. The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission. Nat Rev Neurosci. 2011;13:22–37.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zarate CA Jr, Singh JB, Quiroz JA, De Jesus G, Denicoff KK, Luckenbaugh DA, et al. A double-blind, placebo-controlled study of memantine in the treatment of major depression. Am J Psychiatry. 2006;163:153–5.

    Article 
    PubMed 

    Google Scholar 

  • Zarate C Jr, Machado-Vieira R, Henter I, Ibrahim L, Diazgranados N, Salvadore G. Glutamatergic modulators: the future of treating mood disorders? Harv Rev Psychiatry. 2010;18:293–303.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nasca C, Xenos D, Barone Y, Caruso A, Scaccianoce S, Matrisciano F, et al. L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors. Proc Natl Acad Sci USA. 2013;110:4804–9.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ottestad-Hansen S, Hu QX, Follin-Arbelet VV, Bentea E, Sato H, Massie A, et al. The cystine-glutamate exchanger (xCT, Slc7a11) is expressed in significant concentrations in a subpopulation of astrocytes in the mouse brain. Glia. 2018;66:951–70.

    Article 
    PubMed 

    Google Scholar 

  • Pajarillo E, Rizor A, Lee J, Aschner M, Lee E. The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics. Neuropharmacology. 2019;161:107559.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Baker DA, Shen H, Kalivas PW. Cystine/glutamate exchange serves as the source for extracellular glutamate: modifications by repeated cocaine administration. Amino acids. 2002;23:161–2.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, et al. The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid redox Signal. 2013;18:522–55.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Reissner KJ, Gipson CD, Tran PK, Knackstedt LA, Scofield MD, Kalivas PW. Glutamate transporter GLT-1 mediates N-acetylcysteine inhibition of cocaine reinstatement. Addiction Biol. 2015;20:316–23.

    Article 
    CAS 

    Google Scholar 

  • Nasca C, Bigio B, Zelli D, de Angelis P, Lau T, Okamoto M, et al. Role of the astroglial glutamate exchanger xCT in ventral hippocampus in resilience to stress. Neuron. 2017;96:402–13.e5.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ferreira FR, Biojone C, Joca SR, Guimarães FS. Antidepressant-like effects of N-acetyl-L-cysteine in rats. Behavioural pharmacology. 2008;19:747–50.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Linck VM, Costa-Campos L, Pilz LK, Garcia CR, Elisabetsky E. AMPA glutamate receptors mediate the antidepressant-like effects of N-acetylcysteine in the mouse tail suspension test. Behav Pharmacol. 2012;23:171–7.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chaudhry FA, Lehre KP, van Lookeren Campagne M, Ottersen OP, Danbolt NC, Storm-Mathisen J. Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron. 1995;15:711–20.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Haugeto O, Ullensvang K, Levy LM, Chaudhry FA, Honoré T, Nielsen M, et al. Brain glutamate transporter proteins form homomultimers. J Biol Chem. 1996;271:27715–22.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lehre KP, Danbolt NC. The number of glutamate transporter subtype molecules at glutamatergic synapses: chemical and stereological quantification in young adult rat brain. J Neurosci. 1998;18:8751–7.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Banasr M, Duman RS. Glial loss in the prefrontal cortex is sufficient to induce depressive-like behaviors. Biol psychiatry. 2008;64:863–70.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gittins RA, Harrison PJ. A morphometric study of glia and neurons in the anterior cingulate cortex in mood disorder. J Affect Disord. 2011;133:328–32.

    Article 
    PubMed 

    Google Scholar 

  • Codeluppi SA, Chatterjee D, Prevot TD, Bansal Y, Misquitta KA, Sibille E, et al. Chronic stress alters astrocyte morphology in mouse prefrontal cortex. Int J Neuropsychopharmacol. 2021;24:842–53.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Codeluppi SA, Xu M, Bansal Y, Lepack AE, Duric V, Chow M, et al. Prefrontal cortex astroglia modulate anhedonia-like behavior. Mol Psychiatry. 2023;28:4632–41.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kofuji P, Araque A. G-Protein-Coupled receptors in astrocyte-neuron communication. Neuroscience. 2021;456:71–84.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Eriksson PS, Nilsson M, Wågberg M, Hansson E, Rönnbäck L. Kappa-opioid receptors on astrocytes stimulate L-type Ca2+ channels. Neuroscience. 1993;54:401–7.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Stiene-Martin A, Zhou R, Hauser KF. Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes. Glia. 1998;22:249–59.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Xu M, Bruchas MR, Ippolito DL, Gendron L, Chavkin C. Sciatic nerve ligation-induced proliferation of spinal cord astrocytes is mediated by kappa opioid activation of p38 mitogen-activated protein kinase. J Neurosci. 2007;27:2570–81.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McLennan GP, Kiss A, Miyatake M, Belcheva MM, Chambers KT, Pozek JJ, et al. Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways. J Neurochem. 2008;107:1753–65.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Knoll AT, Carlezon WA Jr. Dynorphin, stress, and depression. Brain Res. 2010;1314:56–73.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Tejeda HA, Shippenberg TS, Henriksson R. The dynorphin/κ-opioid receptor system and its role in psychiatric disorders. Cell Mol Life Sci. 2012;69:857–96.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Zan GY, Sun X, Wang YJ, Liu R, Wang CY, Du WJ, et al. Amygdala dynorphin/κ opioid receptor system modulates depressive-like behavior in mice following chronic social defeat stress. Acta pharmacologica Sin. 2022;43:577–87.

    Article 
    CAS 

    Google Scholar 

  • Wang YJ, Zan GY, Xu C, Li XP, Shu X, Yao SY, et al. The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology. Nat Commun. 2023;14:7903.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bruchas MR, Schindler AG, Shankar H, Messinger DI, Miyatake M, Land BB, et al. Selective p38α MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction. Neuron. 2011;71:498–511.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zan GY, Wang YJ, Li XP, Fang JF, Yao SY, Du JY, et al. Amygdalar κ-opioid receptor-dependent upregulating glutamate transporter 1 mediates depressive-like behaviors of opioid abstinence. Cell Rep. 2021;37:109913.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ehrich JM, Messinger DI, Knakal CR, Kuhar JR, Schattauer SS, Bruchas MR, et al. Kappa opioid receptor-induced aversion requires p38 MAPK activation in VTA dopamine neurons. J Neurosci. 2015;35:12917–31.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bruchas MR, Land BB, Aita M, Xu M, Barot SK, Li S, et al. Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria. J Neurosci. 2007;27:11614–23.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Knackstedt LA, LaRowe S, Mardikian P, Malcolm R, Upadhyaya H, Hedden S, et al. The role of cystine-glutamate exchange in nicotine dependence in rats and humans. Biol psychiatry. 2009;65:841–5.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chen Y, Yao SY, Shu X, Wang YJ, Liu JG. Changes in mRNA and miRNA expression in the prelimbic cortex related to depression-like syndrome induced by chronic social defeat stress in mice. Behavioural brain Res. 2023;438:114211.

    Article 
    CAS 

    Google Scholar 

  • Zhu Y, Wang K, Ma T, Ji Y, Lou Y, Fu X, et al. Nucleus accumbens D1/D2 circuits control opioid withdrawal symptoms in mice. J Clin Invest. 2023;133:e163266.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zhang J, Lu Y, Jia M, Bai Y, Sun L, Dong Z, et al. Kappa opioid receptor in nucleus accumbens regulates depressive-like behaviors following prolonged morphine withdrawal in mice. iScience. 2023;26:107536.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Belcheva MM, Clark AL, Haas PD, Serna JS, Hahn JW, Kiss A, et al. Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes. J Biol Chem. 2005;280:27662–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bruchas MR, Macey TA, Lowe JD, Chavkin C. Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes. J Biol Chem. 2006;281:18081–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kofuji P, Araque A. Astrocytes and behavior. Annu Rev Neurosci. 2021;44:49–67.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bridges R, Lutgen V, Lobner D, Baker DA. Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacol Rev. 2012;64:780–802.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Petr GT, Sun Y, Frederick NM, Zhou Y, Dhamne SC, Hameed MQ, et al. Conditional deletion of the glutamate transporter GLT-1 reveals that astrocytic GLT-1 protects against fatal epilepsy while neuronal GLT-1 contributes significantly to glutamate uptake into synaptosomes. J Neurosci. 2015;35:5187–201.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kalivas PW. The glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 2009;10:561–72.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • John CS, Smith KL, Van’t Veer A, Gompf HS, Carlezon WA Jr, Cohen BM, et al. Blockade of astrocytic glutamate uptake in the prefrontal cortex induces anhedonia. Neuropsychopharmacology. 2012;37:2467–75.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McBean GJ. Cerebral cystine uptake: a tale of two transporters. Trends Pharmacol Sci. 2002;23:299–302.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Bentea E, Demuyser T, Van Liefferinge J, Albertini G, Deneyer L, Nys J, et al. Absence of system xc- in mice decreases anxiety and depressive-like behavior without affecting sensorimotor function or spatial vision. Prog Neuro-psychopharmacol Biol psychiatry. 2015;59:49–58.

    Article 
    CAS 

    Google Scholar 

  • Albertini G, Deneyer L, Ottestad-Hansen S, Zhou Y, Ates G, Walrave L, et al. Genetic deletion of xCT attenuates peripheral and central inflammation and mitigates LPS-induced sickness and depressive-like behavior in mice. Glia. 2018;66:1845–61.

    Article 
    PubMed 

    Google Scholar 

  • Demuyser T, Deneyer L, Bentea E, Albertini G, Femenia T, Walrave L, et al. Slc7a11 (xCT) protein expression is not altered in the depressed brain and system xc- deficiency does not affect depression-associated behaviour in the corticosterone mouse model. World J Biol Psychiatry. 2019;20:381–92.

    Article 
    PubMed 

    Google Scholar 

  • Chaki S. mGlu2/3 receptor antagonists as novel antidepressants. Trends Pharmacol Sci. 2017;38:569–80.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kawasaki T, Ago Y, Yano K, Araki R, Washida Y, Onoe H, et al. Increased binding of cortical and hippocampal group II metabotropic glutamate receptors in isolation-reared mice. Neuropharmacology. 2011;60:397–404.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nasca C, Bigio B, Zelli D, Nicoletti F, McEwen BS. Mind the gap: glucocorticoids modulate hippocampal glutamate tone underlying individual differences in stress susceptibility. Mol Psychiatry. 2015;20:755–63.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Feyissa AM, Woolverton WL, Miguel-Hidalgo JJ, Wang Z, Kyle PB, Hasler G, et al. Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:279–83.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Muguruza C, Miranda-Azpiazu P, Díez-Alarcia R, Morentin B, González-Maeso J, Callado LF, et al. Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment. Neuropharmacology. 2014;86:311–8.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McOmish CE, Pavey G, Gibbons A, Hopper S, Udawela M, Scarr E, et al. Lower [3H]LY341495 binding to mGlu2/3 receptors in the anterior cingulate of subjects with major depressive disorder but not bipolar disorder or schizophrenia. J Affect Disord. 2016;190:241–8.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Sofroniew MV, Vinters HV. Astrocytes: biology and pathology. Acta Neuropathol. 2010;119:7–35.

    Article 
    PubMed 

    Google Scholar 

  • Siracusa R, Fusco R, Cuzzocrea S. Astrocytes: role and functions in brain pathologies. Front Pharmacol. 2019;10:1114.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ongür D, Drevets WC, Price JL. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci USA. 1998;95:13290–5.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • McLaughlin JP, Li S, Valdez J, Chavkin TA, Chavkin C. Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology. 2006;31:1241–8.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Donahue RJ, Landino SM, Golden SA, Carroll FI, Russo SJ, Carlezon WA Jr. Effects of acute and chronic social defeat stress are differentially mediated by the dynorphin/kappa-opioid receptor system. Behav Pharmacol. 2015;26:654–63.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Land BB, Bruchas MR, Schattauer S, Giardino WJ, Aita M, Messinger D, et al. Activation of the kappa opioid receptor in the dorsal raphe nucleus mediates the aversive effects of stress and reinstates drug seeking. Proc Natl Acad Sci USA. 2009;106:19168–73.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Galeotti N, Ghelardini C. Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline. Neuropharmacology. 2012;62:289–96.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Grassmé H, Jernigan PL, Hoehn RS, Wilker B, Soddemann M, Edwards MJ, et al. Inhibition of acid sphingomyelinase by antidepressants counteracts stress-induced activation of P38-Kinase in major depression. Neurosignals. 2015;23:84–92.

    Article 
    PubMed 

    Google Scholar 

  • Bruchas MR, Chavkin C. Kinase cascades and ligand-directed signaling at the kappa opioid receptor. Psychopharmacology. 2010;210:137–47.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Liu-Chen LY, Huang P. Signaling underlying kappa opioid receptor-mediated behaviors in rodents. Front Neurosci. 2022;16:964724.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wadenberg ML. A review of the properties of spiradoline: a potent and selective kappa-opioid receptor agonist. CNS Drug Rev. 2003;9:187–98.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mague SD, Pliakas AM, Todtenkopf MS, Tomasiewicz HC, Zhang Y, Stevens WC Jr., et al. Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats. J Pharmacol Exp Ther. 2003;305:323–30.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Dalefield ML, Scouller B, Bibi R, Kivell BM. The kappa opioid receptor: a promising therapeutic target for multiple pathologies. Front Pharmacol. 2022;13:837671.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Margolis EB, Wallace TL, Van Orden LJ, Martin WJ. Differential effects of novel kappa opioid receptor antagonists on dopamine neurons using acute brain slice electrophysiology. PLoS One. 2020;15:e0232864.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Van’t Veer A, Carlezon WA Jr. Role of kappa-opioid receptors in stress and anxiety-related behavior. Psychopharmacology. 2013;229:435–52.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Azocar VH, Sepúlveda G, Ruiz C, Aguilera C, Andrés ME, Fuentealba JA. The blocking of kappa-opioid receptor reverses the changes in dorsolateral striatum dopamine dynamics during the amphetamine sensitization. J Neurochem. 2019;148:348–58.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wong S, Le GH, Vasudeva S, Teopiz KM, Phan L, Meshkat S, et al. Preclinical and clinical efficacy of kappa opioid receptor antagonists for depression: a systematic review. J Affect Disord. 2024;362:816–27.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Smirnova L, Gräfe A, Seiler A, Schumacher S, Nitsch R, Wulczyn FG. Regulation of miRNA expression during neural cell specification. Eur J Neurosci. 2005;21:1469–77.

    Article 
    PubMed 

    Google Scholar 

  • Mor E, Cabilly Y, Goldshmit Y, Zalts H, Modai S, Edry L, et al. Species-specific microRNA roles elucidated following astrocyte activation. Nucleic Acids Res. 2011;39:3710–23.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schratt GM, Tuebing F, Nigh EA, Kane CG, Sabatini ME, Kiebler M, et al. A brain-specific microRNA regulates dendritic spine development. Nature. 2006;439:283–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Schratt G. microRNAs at the synapse. Nat Rev Neurosci. 2009;10:842–9.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Baudry A, Mouillet-Richard S, Schneider B, Launay JM, Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science. 2010;329:1537–41.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Issler O, Haramati S, Paul ED, Maeno H, Navon I, Zwang R, et al. MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron. 2014;83:344–60.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Issler O, Chen A. Determining the role of microRNAs in psychiatric disorders. Nat Rev Neurosci. 2015;16:201–12.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Torres-Berrío A, Nouel D, Cuesta S, Parise EM, Restrepo-Lozano JM, Larochelle P, et al. MiR-218: a molecular switch and potential biomarker of susceptibility to stress. Mol Psychiatry. 2020;25:951–64.

    Article 
    PubMed 

    Google Scholar 

  • McIntyre RS, Jain R. Glutamatergic modulators for major depression from theory to clinical use. CNS Drugs. 2024;38:869–90.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A, Liu-Chen LY. Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5’-O-(3-[35S]thiotriphosphate) binding in the guinea pig. J pharmacology Exp therapeutics. 2011;339:438–50.

    Article 
    CAS 

    Google Scholar 

  • Russell SE, Rachlin AB, Smith KL, Muschamp J, Berry L, Zhao Z, et al. Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats. Biol psychiatry. 2014;76:213–22.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chen Y, Jiang Y, Jiang X, Zhai C, Wang Y, Xu C. Identification and experimental validation of hub genes underlying depressive-like behaviors induced by chronic social defeat stress. Front Pharmacol. 2024;15:1472468.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Golden SA, Covington HE 3rd, Berton O, Russo SJ. A standardized protocol for repeated social defeat stress in mice. Nat Protoc. 2011;6:1183–91.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen Y, Wang CY, Zan GY, Yao SY, Deng YZ, Shu XL, et al. Upregulation of dynorphin/kappa opioid receptor system in the dorsal hippocampus contributes to morphine withdrawal-induced place aversion. Acta pharmacologica Sin. 2023;44:538–45.

    Article 
    CAS 

    Google Scholar 

  • Christianson JP, Flyer-Adams JG, Drugan RC, Amat J, Daut RA, Foilb AR, et al. Learned stressor resistance requires extracellular signal-regulated kinase in the prefrontal cortex. Front Behav Neurosci. 2014;8:348.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ameneiro L, Zalcman G, Robles A, Romano A. Characteristics of the Reminder that Triggers Object Recognition Memory Reconsolidation in Mice. Neuroscience. 2022;497:206–14.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Griffin WC 3rd, Haun HL, Hazelbaker CL, Ramachandra VS, Becker HC. Increased extracellular glutamate in the nucleus accumbens promotes excessive ethanol drinking in ethanol dependent mice. Neuropsychopharmacology. 2014;39:707–17.

    Article 
    CAS 
    PubMed 

    Google Scholar 

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  • S&P hits a new high at close as strong growth lifts tech stocks

    S&P hits a new high at close as strong growth lifts tech stocks

    US share markets finished higher on Tuesday, with the S&P 500 closing at a record level, as fresh economic data showed the US economy is running hotter than expected.

    A wave of reports, led by stronger-than-forecast growth figures, pushed government bond yields higher and helped lift growth stocks, particularly big technology names.

    The US Commerce Department said the economy grew at an annual rate of 4.3 per cent in the September quarter. That was the fastest pace since the September quarter of 2023 and well above the 3.3 per cent forecast from economists surveyed by Reuters. Solid consumer spending did most of the heavy lifting.

    The figures were released late because of the 43-day US government shutdown. Many analysts had expected growth to slow in the December quarter, but the surprise strength has changed how markets see the outlook for interest rates.

    Investors are now less confident the US Federal Reserve will cut rates in January. Short-term bond yields rose in response, according to CME’s FedWatch Tool.

    “The bond market didn’t like this news,” said Stephen Massocca, senior vice president at Wedbush Securities in San Francisco.

    “It seems to me that when we lose this battle, growth does well, and growth’s doing well today,” he said.
    “But if you’re a food company, or you’re a chemical company, or you’re an oil and gas company, or even if you’re like a private credit company, that’s bad news. Unless interest rates go down, it’s bad.”

    Tech leads the market higher

    The Dow Jones Industrial Average rose 79.73 points, or 0.16 per cent, to 48,442.41. The S&P 500 gained 31.30 points, or 0.46 per cent, to 6,909.79. The Nasdaq Composite climbed 133.02 points, or 0.57 per cent, to 23,561.84.

    Growth stocks clearly led the way. The S&P 500 growth index rose 0.8 per cent, while value stocks barely moved.

    Artificial intelligence-linked shares added to recent gains after last week’s sell-off, which was driven by worries that valuations had run too far ahead of profits and that heavy spending by AI companies could weigh on earnings.

    Nvidia jumped 3.0 per cent, making it the single biggest driver of gains in the S&P 500. Amazon, Alphabet and Broadcom also rose more than 1.0 per cent.

    Not all good news

    Away from the headline growth number, other data painted a mixed picture of the economy.

    US consumer confidence fell in December, as households grew more anxious about jobs and incomes. Factory output was flat in November after falling the month before.

    Even so, markets remain on a strong footing. All three major US share indexes are on track for a third straight year of gains. The S&P 500 and the Dow are also heading for an eighth consecutive monthly rise.

    That recent momentum has fuelled hopes of a so-called “Santa Claus rally” – a seasonal pattern where the S&P 500 often rises in the final five trading days of the year and the first two sessions of January, according to the Stock Trader’s Almanac. This year, that period runs from Wednesday through to 5 January.

    Holiday slowdown begins

    Trading was already quieter than usual and is expected to thin out further as Christmas approaches.

    US share markets will close early at 1.00pm ET on Wednesday and will be shut on Thursday for Christmas. About 14.01 billion shares changed hands during the session, below the recent 20-day average of 16.67 billion.

    Company moves to watch

    Shares in ServiceNow fell 1.5 per cent after the software company agreed to buy cybersecurity startup Armis for US$7.75bn (A$11.58bn) in cash.

    US military shipbuilder Huntington Ingalls edged up 0.3 per cent after President Donald Trump announced plans for a new “Trump class” of battleships, which he said would be larger, faster and “100 times more powerful” than existing vessels.

    Miner Freeport-McMoRan climbed 2.5 per cent to a 15-month high of US$52.29 (A$78.13), helped by record copper prices and a higher price target from Wells Fargo.

    Market breadth

    Falling stocks slightly outnumbered those that rose. On the Nasdaq, declines were more widespread.

    The S&P 500 recorded 35 new 52-week highs and five new lows. The Nasdaq Composite logged 70 new highs and 178 new lows.

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  • Shoppers tipped to splash cash in Boxing Day spree

    Shoppers tipped to splash cash in Boxing Day spree

    A $1.6 billion Boxing Day

    Australians are expected to splash $1.6 billion on Boxing Day sales alone, as budget-conscious shoppers gravitate towards a bargain despite growing cost-of-living pressures.

    Sales are tipped to rise by 4.3 per cent, delivering strong end-of-year momentum for retailers according to data from the Australian Retailers Association and Roy Morgan.

    The spending surge is expected to continue into the coming week, with shoppers projected to spend $3.8 billion through to the new year.

    Solid pre-Christmas spending

    Early Christmas purchasing and a solid build-up through December have created a strong platform for Boxing Day trading, the association’s chief executive Chris Rodwell said.

    “Retailers are finishing the year on solid footing,” he said.

    “The growth we’re seeing highlights both the resilience of the sector and the enduring appeal of Boxing Day as a premier discount event.”

    The products expected to drive the numbers

    Household goods are expected to be the most popular items on Boxing Day, with $476 million in sales forecast, followed by clothing, footwear and accessories at $226 million.

    Hospitality spending is tipped to increase by 6.8 per cent from last year to $141 million.

    Supporting local business

    Bargain shoppers are being urged to support local retailers during the festive spending period, with Mr Rodwell noting every purchase helps fund local jobs, training, wages and community investment.

    “Ultra low-cost offshore platforms like Temu and Shein cannot match that contribution and are not held accountable to the same standards,” he said.

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