Category: 3. Business

Earlier treatment options, such as vorasidenib (Vorangio), could address unmet needs for patients with slow-growing IDH-mutant gliomas, according to real-world data reported in a poster presented during the 2025 Society for Neuro-Oncology Annual Meeting.

In the study, vorasidenib treatments demonstrated minimal toxicity for patients with slow-growing IDH-mutant gliomas researchers have reported— with a treatment approved in 2024 by the FDA, possibly helping to address this issue.

Real-world observation rates and treatment patterns among patients aged 12 years and older with IDH-mutated glioma and their implications for targeted therapy use were reported.

Researchers reported that 5,894 with IDH-mutant glioma were identified, of whom 3,212, or 54%, had grade 2 tumors and 2,682, or 46%, had grade 3 tumors. The median age at diagnosis was 39 (range 31-50) years.

After initial surgery, 2,058 patients were on observation, and 3,660 initiated therapies within 90 days. Of the former group, 1,568 remained on observation until the end of the study period in 2022, while 490 received chemotherapy/radiation after an initial period of observation.

By 90 days after surgery, 70% of patients who were age 40 years or older had initiated therapy, compared with 57% of those aged 12 to 39 years. At 90 days, 43% of patients age 12 to 39 years and 30% of patients age 40 years or older remained on observation, with 34% and approximately 22%, respectively, still on observation after 5 years.

Additionally, by 90 days following surgery, 47% of patients with a grade 2 glioma and 82% of patients with a grade 3 glioma had initiated therapy, and at 90 days 53% of patients with a grade 2 glioma and 18% with a grade 3 glioma remained on observation, with 43% and 10%, respectively, still on observation after 5 years.

“Historical management patterns show that a substantial proportion of patients with [IDH]-mutated glioma were managed with observation, suggesting an unmet need for an effective early intervention,” researchers concluded in their poster presentation of the data. “While younger patients (aged 12 to 39 years) and those with World Health Organization (WHO) grade 2 glioma were more likely to undergo observation, a substantial proportion of patients aged [at least] 40 years and those with WHO grade 3 glioma also underwent observation.”

Researchers further noted that the fact that patients age 40 years and older or those with grade 3 glioma received radiation or chemotherapy, given those treatments’ well-established long-term adverse effects, should highlight the need for less-toxic alternative treatment options.

Vorasidenib, researchers stated in the poster “offers an early, effective, low-toxicity treatment option across these patient groups.”

More Information About Vorasidenib

Vorasidenib was approved the FDA in August 2024 for the treatment of adult and pediatric patients at least 12 years old with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation following surgery including biopsy, sub-total resection, or gross total resection. An IDH1 and IDH2 inhibitor, vorasidenib was the first systemic therapy approved by the agency for patients with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation, according to a notice from the FDA.

Additionally, longer-term results announced earlier this month showed that vorasidenib continued to benefits patients in this population, according to updated phase 3 INDIGO trial data published in The Lancet Oncology.

At a median follow-up of 20.1 months, patients treated with vorasidenib experienced superior progression-free survival to those who received placebo, with disease progression in 32% of patients who received the drug and 64% of those who did not.

References

1. “Real-world observation rates and treatment patterns in IDH-mutated glioma: Implications for targeted therapy use;” Ostrom Q., Bhagnani T., Benedetti J. et al., presented at the 2025 Society for Neuro-Oncology Annual Meeting, Nov. 19 to 23, Honolulu, Hawaii, poster INNV-37.
2. “Voranigo Approved by FDA For Astrocytoma or Oligodendroglioma,” CURE, Aug. 6, 2024; https://www.curetoday.com/view/voranigo-approved-by-fda-for-astrocytoma-or-oligodendroglioma
3. “Voranigo Continues to Benefit Patients With Grade 2 IDH-Mutated Glioma,” CURE, Nov. 4, 2025; https://www.curetoday.com/view/voranigo-continues-to-benefit-patients-with-grade-2-idh-mutated-glioma

NVIDIA Corporation (NASDAQ:NVDA) is one of the AI Stocks Making Headlines on Wall Street. On November 25, Bank of America maintained a positive outlook on the stock, along with AMD and Broadcom, despite intensifying competition in the artificial intelligence chip market.

The reiterated buys follows reports that Meta (META) is considering using Google’s (GOOG) TPUs in addition to its existing Nvidia GPU supply.

“Late yesterday, media reports indicated the possibility of Google renting out the TPUs to Meta next year, potentially followed by on-premise deployments (with Meta and maybe others) in 2027. Neither company has made any official comments regarding any such transaction, but if true, it can intensify the competitive landscape for Meta’s current GPU suppliers NVDA and AMD.” – Bank of America analyst Vivek Arya.

A data analyst with a headset, looking intently at the information unfolding on her screen.

In response, Nvidia issued a statement contending that it is still the leader in the market.

“NVIDIA is a generation ahead of the industry — it’s the only platform that runs every AI model and does it everywhere computing is done. NVIDIA offers greater performance, versatility, and fungibility than ASICs, which are designed for specific AI frameworks or functions.”

According to Arya, Nvidia will still likely dominate the market, albeit at a 75% market share from the estimated 85% it currently holds.

NVIDIA Corporation (NASDAQ:NVDA) specializes in AI-driven solutions, offering platforms for data centers, self-driving cars, robotics, and cloud services.

While we acknowledge the potential of NVDA as an investment, we believe certain AI stocks offer greater upside potential and carry less downside risk. If you’re looking for an extremely undervalued AI stock that also stands to benefit significantly from Trump-era tariffs and the onshoring trend, see our free report on the best short-term AI stock.

READ NEXT: 10 AI Stocks in Focus on Wall Street and 10 Hot AI Stocks to Keep on Your Radar

Disclosure: None.

Story Continues

If you watched TV at odd hours in the 1990s and early 2000s, you probably remember QVC, the home shopping network selling viewers everything from kitchen appliances to kids’ toys, often for several “easy” payments over time.

Well, there’s a new age version of that phenomenon that’s found a home on TikTok and other platforms, but instead of broadcasting for an hour between the nightly news and sitcom reruns, some sellers are streaming for hours.

It can also be incredibly lucrative if you find the right niche.

Live selling on platforms like TikTok, YouTube, and Instagram combines livestreaming and e-commerce. Sellers are hosting live “shows” and chatting with their audience in real time, while viewers are buying directly from the stream without leaving the app.

“It’s like QVC to a new generation,” e-commerce veteran Leo Limin, who started selling smart light bulbs on Amazon in the mid-2010s, told Business Insider. “Some brands sell through thousands and thousands of items in a matter of a couple of hours, like $50,000 worth of products, for example, in two hours.”

Harry Luu is one of those sellers. He brought in $42,000 in one day by selling two rare plants — one for $26,000 and the other for $16,000 — on Palmstreet, a live shopping app for rare plants and other unique goods.

“I would call myself a plantdemic baby,” said the former mathematician. “During COVID, a lot of people picked up a hobby of some sort, and plants were my escape at the time.”

His plant collection and cultivation hobby quickly evolved into a lucrative side hustle and, eventually, a sustainable career. He left academia in 2024 to run Plant Zaddy Therapy full-time.

Clinton Benninghoff runs Golf Headquarters, a Midland-based brick-and-mortar store that sells golf apparel and equipment. Last summer, after hearing about an auction-style platform called Whatnot, he downloaded the app out of curiosity. He signed up to be a seller and, using his iPhone, set up his first stream from his office.

“I just set up the camera by my door, pointed it toward all my bags full of golf clubs, and clicked to go live. I had no idea what I was doing,” he told BI. “That first day, I think I was live for like 20 minutes. I sold a putter, and everybody in my stream was actually telling me how to stream.”

Less than a year later, in February 2025, he sold over $100,000 in products in a six-hour live show, a Whatnot record at the time in the golf category.

“Everybody was recording on their phones when we finally hit it. I was so hoarse. I didn’t have a voice,” he recalled. “That February 8 show let us know that we can do this at a high level.”

Business Insider confirmed the claims made by each seller featured by reviewing screenshots of their sales dashboards.

The unique advantage of live selling: Convenience plus knowing exactly what you’re getting

Before joining Palmstreet, Luu said that he and other plant collectors primarily listed their products on Facebook. But, as live selling platforms started to gain traction, “there were quite a few of us who migrated, because it was a lot faster, it was a lot easier, and it was a lot more interactive and fun.”

Selling online is loads cheaper than owning and operating a brick-and-mortar — and, depending on the platform you’re using, potentially easier to acquire customers, he added.

“If you open a store, you are still subject to the fact that people have to walk into your store. When you’re on a major platform such as Palmstreet, and they have already built up a good enough clientele, you have a lot more walk-ins, quote unquote.”

Benninghoff said that during his most-viewed Whatnot stream, he had 1,600 potential buyers in the room. He has sold and shipped products to buyers across the lower 48 states, as well as in Hawaii, Alaska, Puerto Rico, and South Africa.

Of course, you don’t get the same face-to-face interaction as you do with a brick-and-mortar, and customers can’t pick up products with their two hands, but it’s the next best thing. Consumers can ask questions in real time and see the product from all angles.

“It gives you the convenience of being at home, but also allows the buyer the flexibility of actually interacting and clarifying before they pull the trigger,” said Luu. “And I think that is one of the greatest advantages of live selling.”

Not every e-commerce business has bought in. Jonathan Cohen, the CMO of two eight-figure Amazon brands, uses TikTok live, but not because he thinks it’s the wave of the future or even a particularly effective way to move product.

“We do live selling, not so much to generate huge amounts of revenue, but to talk to our customers. We get our R&D and our customer feedback directly from people who are inside our live chat rooms,” he said, and warns against putting all of your eggs in the live selling basket. “I wouldn’t say it’s going to be any single person’s ticket to success.”

What it takes to succeed as a live seller

Benninghoff describes Whatnot as “an entertainment app” as much as it is a marketplace.

“You’re building this community of people that are following a personality,” said the part-time pastor, who thrives in a public speaking environment. For him, setting up a camera and talking to strangers came naturally. It was the juggling of multiple pieces that took some getting used to.

“The biggest learning curve was how to run an auction and stay engaged with people that are asking questions in the chat while holding up the item at the right angle and just doing it all at the same time.”

It helps to be extroverted and a bit of a “performer,” said Luu, who had experience managing large Zoom lectures in his previous career, but it’s not essential. “Different people resonate with different people. You will inherently attract your own crowd.”

Casey Wehr, who works full-time at a private equity firm and has built a seven-figure side hustle selling sports cards with his two sons on Whatnot, has mastered the art of building excitement throughout live shows.

There are two main ways he’s earning money on Whatnot. There’s the live auction format, in which he’ll grab an item, put it in front of the camera, and start a 15-second auction. “It’s very fast paced, it’s fun, it’s engaging,” he said.

Viewers can also buy packs of cards directly from his store, Krunk Cards, at any point during the stream, and he’ll do a “sealed wax opening” on camera. “What’s fun about the sealed wax is that it’s a community event. It’s fun to open product just when you go buy it from the store and take it home, but there’s a whole other level of excitement opening a box with 100 other people in the room.”

As Wehr says, “inventory is key.” You want to be selling something that generates enough excitement that viewers will want to bid.

But it’ll only get you so far in the live selling space.

“You can have a great product, but to have big viewership and a big community, you’ve got to engage with those people,” said Benninghoff. “You’ve got to make them feel like they are family — not just a person buying items from you.”

Armstrong World Industries (AWI) delivered a strong third-quarter update, topping forecasts for adjusted earnings and net sales while raising its outlook for 2025. This financial momentum has been met with a more upbeat mood among investors.

See our latest analysis for Armstrong World Industries.

Momentum has picked up for Armstrong World Industries this year, with a 35.4% share price return since January and a one-year total shareholder return of nearly 20%. Investors seem to be rewarding the company’s upgraded outlook and recent string of upbeat earnings, supporting a more positive long-term view on the stock.

If this kind of upward momentum has you interested in broader market trends, now is the perfect opportunity to uncover other fast growing stocks with strong insider support through our fast growing stocks with high insider ownership.

With shares already up strongly year to date and trading just below analyst price targets, investors now face a key question: Is Armstrong World Industries still undervalued, or is all the future growth already priced in?

With Armstrong World Industries closing at $189.74 versus the narrative fair value estimate of $207.1, the stage is set for a deeper look at what is driving the disconnect between price and value in the eyes of the most closely followed forecasters.

Ongoing strategic acquisitions (for example, 3form and Zahner) and successful integration are broadening Armstrong’s addressable market to capture additional spaces within commercial buildings and accelerate cross-selling opportunities. This is expected to support both revenue growth and improved net margins through scale and operational synergies.

Read the complete narrative.

Want to know what fuels this surprisingly optimistic price target? See how the narrative’s biggest bets on future sales, profit margins and sector leadership play out in numbers. Is Armstrong’s growth story credible or are expectations set sky high? Click through and see just how bold these projections really are.

Result: Fair Value of $207.1 (UNDERVALUED)

Have a read of the narrative in full and understand what’s behind the forecasts.

However, risks remain. Prolonged soft commercial construction demand or ineffective acquisition integration could quickly reverse Armstrong’s current growth momentum.

Find out about the key risks to this Armstrong World Industries narrative.

Shifting from narrative fair value to a different lens, the current price-to-earnings ratio stands at 26.8x, outpacing the industry’s 18.9x and also above the fair ratio of 21.8x. This highlights a valuation premium, which may reflect investor confidence. However, it also leaves less margin for error if expectations falter. Could the stock be riskier at these levels, or does the market know something others do not?

See what the numbers say about this price — find out in our valuation breakdown.

You do not have to take these conclusions at face value. Explore the numbers, follow your own instincts, and assemble your unique take in just a few minutes. Do it your way

A good starting point is our analysis highlighting 3 key rewards investors are optimistic about regarding Armstrong World Industries.

Smart investors always keep their edge sharp. Take the next step now by checking out handpicked stocks matching themes and opportunities you will not find anywhere else.

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Companies discussed in this article include AWI.

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

• Thinking about whether Global Business Travel Group stock is a real bargain or just flying under the radar? You are not alone. Figuring out the true value of this stock has plenty of investors curious.

• The share price jumped 8.4% over the past week, but it is still down 1.7% for the month and sits nearly 18% below where it was a year ago. This hints at both fresh optimism and lingering skepticism in the market.

• Recently, industry updates and M&A discussions have kept Global Business Travel Group in the spotlight. Investors are weighing announcements about new strategic partnerships and travel demand trends, all of which are shaping sentiment around the stock’s future potential.

• If you are keeping score, Global Business Travel Group currently rates a 6 out of 6 on our valuation checklist, meaning it is deemed undervalued on every single metric we track. Let’s dive into what that score really means, and stick around for a look at an even more insightful take on valuation coming later in the article.

Find out why Global Business Travel Group’s -17.9% return over the last year is lagging behind its peers.

The Discounted Cash Flow (DCF) model determines a company’s intrinsic value by projecting its future free cash flows and discounting them back to today’s dollars. This approach helps investors assess whether a stock’s current price fairly reflects its future earning power.

For Global Business Travel Group, the latest reported Free Cash Flow stands at $129.7 Million. Projections point to continued growth, with analysts expecting FCF to reach $425 Million by 2028. Although detailed analyst estimates end at five years, Simply Wall St extends the outlook by extrapolating steady growth up to 2035, with future cash flows peaking at $625.9 Million. All projections are in US dollars.

Using these figures, the DCF model estimates the stock’s fair value at $14.21 per share. This valuation signals a substantial discount because the current market price sits about 45.8% below this intrinsic value.

In summary, Global Business Travel Group appears undervalued at today’s prices based on the DCF analysis alone, which may be of interest to value-focused investors.

Result: UNDERVALUED

Our Discounted Cash Flow (DCF) analysis suggests Global Business Travel Group is undervalued by 45.8%. Track this in your watchlist or portfolio, or discover 920 more undervalued stocks based on cash flows.

Head to the Valuation section of our Company Report for more details on how we arrive at this Fair Value for Global Business Travel Group.

The Price-to-Sales (P/S) ratio is often considered a reliable benchmark for valuing profitable companies, especially when earnings may be less consistent year over year. This ratio is particularly useful in sectors like hospitality, where revenue growth can signal underlying business health even when profits fluctuate due to temporary costs or investments.

Investors should keep in mind that normal or fair P/S ratios reflect not just a company’s growth prospects, but also risk factors such as market volatility and profit consistency. Companies with better growth outlooks or lower risks typically command higher multiples, while slower or riskier businesses tend to trade at discounts.

Currently, Global Business Travel Group trades at a P/S ratio of 1.60x. For comparison, the industry average sits at 1.66x, and close peers average 3.45x. Simply Wall St’s proprietary Fair Ratio, which accounts for the company’s unique combination of earnings growth, profit margins, industry, market cap, and risk profile, stands at 2.12x.

This Fair Ratio offers a tailored benchmark and is more insightful than a straight comparison to peers or the industry average, as it incorporates projections and qualitative factors that standard multiples do not reflect.

In this case, Global Business Travel Group’s current P/S ratio is clearly below the Fair Ratio. This points to attractive value at current levels, suggesting the stock is undervalued by this metric.

Result: UNDERVALUED

PS ratios tell one story, but what if the real opportunity lies elsewhere? Discover 1443 companies where insiders are betting big on explosive growth.

Earlier we mentioned that there is an even better way to understand valuation, so let’s introduce you to Narratives. A Narrative is a story-driven framework for investing, where you connect your perspective about a company—its opportunities, risks, and the reasons behind its potential—directly with the numbers, such as forecasts of future revenue and profit margins, to form a unique view of fair value.

Unlike static data points, Narratives invite you to actively consider how business events and your own research shape the financial future you expect. On Simply Wall St’s Community page, millions of investors use Narratives as a simple tool to articulate their reasoning, see how their story translates into numbers, and instantly compare the resulting Fair Value to the current market price.

Narratives make it easier to decide when to buy or sell by updating dynamically as new information, such as earnings results or industry news, emerges. For example, some Global Business Travel Group Narratives are built around bullish views that integration of acquisitions and digital expansion will drive fair value as high as $11.00 per share, while more cautious investors, focusing on uncertain travel demand and integration risks, arrive at targets as low as $7.00.

Do you think there’s more to the story for Global Business Travel Group? Head over to our Community to see what others are saying!

This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

Companies discussed in this article include GBTG.

Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com