Category: 3. Business

  • Michael Burry launches newsletter to lay out his AI bubble views after deregistering hedge fund

    Michael Burry launches newsletter to lay out his AI bubble views after deregistering hedge fund

    Michael Burry attends the New York premiere of “The Big Short” at the Ziegfeld Theater in New York City on Nov. 23, 2015.

    Jim Spellman | WireImage | Getty Images

    Michael Burry, the investor who shot to fame for calling the housing crash before 2008, has launched a Substack newsletter after deregistering his hedge fund, aiming to lay out in detail his increasingly bearish thesis on artificial intelligence.

    “The Big Short” investor is capitalizing on the massive audience he’s built on X, where 1.6 million followers have long parsed his cryptic posts. His new publication, titled “Cassandra Unchained” with a $379 annual subscription fee, arrives with a familiar warning: He believes markets are once again deep in bubble territory.

    In announcing the launch, Burry referenced the parallels between the late-1990s tech mania and today’s rush into AI and how the bubbles have been ignored by policymakers, in his view.

    Feb 21, 2000: SF Chronicle says I’m short Amazon. Greenspan 2005: ‘bubble in home prices … does not appear likely.’ [Fed Chair Jerome] Powell ’25: ‘AI companies actually… are profitable… it’s a different thing. ‘I doubted if I ever should come back. I’m back. Please join me,” Burry wrote in a post Sunday night on X.

    He highlighted then-Fed Chair Alan Greenspan’s 2005 insistence that U.S. housing prices showed no signs of a bubble, just two years before the subprime implosion validated Burry’s famous “Big Short.” And now he argues history is rhyming again.

    Like the dot-com era, investors are extrapolating exponential growth, dismissing profitability concerns and funding massive capital expenditures on the assumption that the technology will rewrite the economy, he believes.

    The investor noted Powell has waved off bubble fears, saying that AI companies are “actually profitable” and “a different thing” from past booms,

    “This is different in the sense that these companies, the companies that are so highly valued, actually have earnings and stuff like that,” Powell said during a news conference in October.

    Burry took it as an eerie echo of the assurances offered by Greenspan two decades ago. At the height of the dot-com boom, Burry was publicly short Amazon. Today, he has been openly bearish on the poster children of the AI boom, Nvidia and Palantir.

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  • Amazon Leo introduces Ultra antenna with 1 Gbps speeds, begins enterprise preview

    Amazon Leo introduces Ultra antenna with 1 Gbps speeds, begins enterprise preview

    Amazon Leo is designed to extend reliable, high-speed internet to those beyond the reach of existing networks, including the millions of businesses, government entities, and organizations operating in places without reliable connectivity. Amazon Leo will help close critical connectivity gaps across major industries, from energy and manufacturing to media and transportation, and these announcements represent another important step for the program as it moves from the deployment phase toward commercial operations.

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  • The transformative power of AI: Europe’s moment to act

    The transformative power of AI: Europe’s moment to act

    Speech by Christine Lagarde, President of the ECB, BratislavAI Forum on artificial intelligence and education as part of an OECD high-level event to mark the 25th anniversary of “Better Policies for Better Lives”, Bratislava

    Bratislava, 24 November 2025

    It’s a privilege to speak with you today about artificial intelligence.

    In 1987 Robert Solow famously remarked that “you can see the computer age everywhere but in the productivity statistics.”

    The same observation could be made today. We see AI advancing at remarkable speed. Yet its aggregate impact is still barely visible in the data.

    Over the past year global corporate investment in AI reached USD 252 billion, and private AI firms raised a record USD 100 billion.[1] Five leading US investors in terms of capital expenditure are now companies that focus heavily on AI. None of these companies numbered among the top ten investors a decade ago. [2]

    Some view this surge as temporary exuberance running ahead of underlying fundamentals. But a debate framed only in terms of short-term ups and downs may miss the bigger picture.

    History offers many examples of intense investment waves that – despite swings in the investment cycle – ultimately left behind transformative technologies that reshaped economies for decades.[3]

    So the key question is not whether there are cycles – that is almost certain – but how long it will take before the enduring productivity benefits become visible.

    And there are reasons to believe AI could spread faster, and deliver tangible economic gains sooner, than previous technology waves.

    If that is the path we are on – and I believe it may be – Europe needs to position itself accordingly. We need to remove all the obstacles that stop us from embracing this transformation. Otherwise we risk letting the wave of AI adoption pass us by and jeopardise Europe’s future.

    History shows: disruptions first, benefits later

    To understand what is at stake, it is useful to look at history.

    Earlier general purpose technologies, such as electricity, computers or the internet, followed a recognisable trajectory. Disruption arrived early, with broad-based productivity gains only emerging slowly.[4]

    For example, it took around thirty years before the impact of electricity showed up clearly across the economy. Power grids had to be built, factories redesigned and workers reallocated from legacy tasks to new ones.

    Computers, too, required long-term investments in hardware, software, skills and new business models before they translated into measurable improvements.

    If Europe’s AI wave resembles the spread of electricity in the 1920s, annual productivity growth could be about 1.3 percentage points higher. But if it follows the US digital boom of the late 1990s, the boost would be closer to 0.8 points.[5] Even that lower bound would be significant for Europe, marking a clear step up from recent trend productivity.

    Could this time be different?

    But AI has features that could compress this cycle and push forward even greater productivity gains. Two features – innovation and diffusion – point to a faster path.

    The first is that frontier innovation may accelerate because of the recursive nature of AI.

    AI systems can use their own output to enhance their performance in a continuous loop. This can lower not only the cost of producing goods and services, but also the cost of generating new ideas.[6]

    For instance, in fifty years, science resolved approximately 200,000 protein structures. AI achieved over 200 million protein structure predictions in about one year, vastly expanding the knowledge frontier.[7]

    This represents a significant change in the inputs to research and development. As the knowledge base expands almost overnight, downstream discovery can compound sooner, even before every lab or firm has fully reorganised.

    By accelerating the production of ideas, AI can lift not just the level of productivity but potentially the growth rate itself.[8] Some estimates suggest that such AI-augmented R&D could double recent US productivity growth rates to between 1.6 and 2.4% annually – faster than previous technology waves.[9]

    Second, the diffusion of AI technologies can be faster because much of the supporting infrastructure already exists.

    It is true that there are bottlenecks. The current wave of investment in hyperscalers shows that compute capacity remains a constraint. Training and deploying larger models requires substantial investment in data centres and energy. In Europe we face particular challenges in this respect, given our higher energy costs and longer permitting delays.

    But unlike past technologies, such as electricity or computers that required new physical networks or coding skills, AI runs on existing internet devices and communicates with users through human language.

    Wide-scale use can therefore proceed even before the infrastructure build-out is complete. Many AI applications already deliver gains on existing hardware. So while a lack of computing capacity holds back the pace of model development, it does not necessarily block diffusion across the wider economy.[10]

    Moreover, the infrastructure itself is advancing quickly. While Moore’s Law forecasts a doubling in chip capacity every two years, AI model compute power has been doubling every six months – four times faster.

    What Europe stands to gain

    What does this mean for Europe?

    The stakes could be extraordinarily high.

    With the United States and China ahead of the field, Europe has already missed the opportunity to be a first mover in AI. And we still bear the costs of having been slow adopters during the last digital revolution. We cannot afford to make the same mistake again.

    Yet the story is far from over. Europe can still emerge as a strong second mover if it acts decisively. Our goal should not be to out-build the leading AI models, but rather to deploy AI across the board. By focusing on rapid adoption and smart use of existing AI technologies across our wide-ranging industries, Europe can turn a late start into a competitive edge.[11]

    Our economy is highly diversified. The top ten firms in the US stock market account for roughly 40% of the market across just four sectors, whereas the top ten in the EU account for no more than 18% across almost twice as many sectors.

    And European firms are already adopting generative AI on a similar scale to those in the United States. What the ECB is hearing from large European companies confirms this trend: many are investing heavily in databases, cloud solutions and AI, with providers of these services reporting double-digit growth.[12]

    But to turn these benefits into a competitive advantage, we need to connect data across sectors. Thanks to industrial-scale data spaces, companies can share operational data and create training sets for AI models that no single firm could assemble alone.[13]

    Initiatives like Manufacturing-X and Catena-X in the automotive sector foster collaboration in data sharing, while the European Health Data Space enables interoperable health records, allowing us to leverage the broad anonymised patient datasets generated by our universal healthcare systems.[14]

    But these efforts will not be enough on their own.

    If our data spaces use technology stacks that are owned and governed outside Europe, we deepen – rather than reduce – our strategic dependencies. We must diversify critical parts of the AI supply chain and avoid single points of failure. In the foundational layers, such as compute capacity based on chips and data centres, we should maintain a minimum capacity.

    In the application layer, Europe should leverage the power of the Single Market to enforce interoperability and open standards. This will encourage competition among large models and prevent the kind of “lock-in” that has occurred with technology platforms in the past.

    Moreover, we must overcome a familiar set of old barriers that have prevented us from being first movers in the past.

    If we allow our energy costs to stay high, if regulations remain fragmented, and if capital markets fail to integrate and channel long-term, risk-bearing funding at scale, AI will diffuse more slowly.

    And this time, the consequences extend beyond losing the race in AI models. We would eventually face a further loss of competitiveness for many of our sectors and industries.

    Conclusion

    Let me conclude.

    “It’ll be ten times bigger than the Industrial Revolution – and maybe ten times faster.” These words from Demis Hassabis – joint winner of the 2024 Nobel Prize in Chemistry for his AI research – capture the potential scale and speed of what may lie ahead.

    So the question is no longer whether this new frontier will arrive, but how soon – and the pace of progress in recent years suggests it is likely to be sooner than our institutions and regulations are prepared for.

    That means acting now to clear the obstacles that would slow AI diffusion and so delay prosperity for all Europeans in the decades ahead.

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  • Intercontinental Exchange (ICE) and Benchmark (BMI) Launch Lithium and Cobalt Futures Contracts

    Intercontinental Exchange (ICE) and Benchmark (BMI) Launch Lithium and Cobalt Futures Contracts

    Intercontinental Exchange (NYSE: ICE) and Benchmark Mineral Intelligence (BMI) today – Monday 24 November – announce the launch of new lithium and cobalt futures contracts settled against Benchmark’s trade‑verified price assessments.

    Their listing on ICE Futures  Europe represents another milestone in the maturation of the battery metals market – connecting dependable physical market benchmarks to globally regulated trading venues.

    Closing the basis risk gap

    For many commercial participants in the battery metal supply chain, aligning physical market pricing with financial market instruments has been challenging.

    Variations between different reference prices have created measurable basis risk and made it difficult for some treasuries to achieve hedge accounting treatment under IFRS guidelines.

    The Benchmark (BMI) futures contracts on ICE, settled against Benchmark’s IOSCO‑assured, transaction‑based assessments, now offer a route to closer alignment between physical exposures and financial hedges.

    This development improves pricing transparency and provides corporate and financial users with the tools to manage lithium and cobalt price risk more effectively across both physical and derivative markets.

    “These contracts expand, rather than compete with, existing lithium and cobalt derivatives by addressing an unmet hedging need for the majority of the ex‑China supply chain,” shared Daniel Fletcher-Manuel, Benchmark’s Director of Indexing & Derivatives.

    “They provide a transparent, regulated pathway for manufacturers, producers, and investors to manage battery metal price exposure across the same indices that underpin billions of dollars in offtake and supply agreements” he added.

    Benchmark Chief Operating Officer, Caspar Rawles, commented:

    “For the first time, participants across the supply chain, from producers to consumers and financial institutions, can trade using Benchmark’s market leading, trusted price assessments, backed by years of independent data, analysis, and market specific methodologies.This is a defining step for the global energy transition.

    “By bringing transparent and independently verified transaction prices for lithium and cobalt to regulated futures markets, we’re helping to build confidence, manage risk, and support the sustainable growth of supply chains powering these new energy supply chains.”

    About the partnership

    Intercontinental Exchange (ICE) operates some of the world’s leading exchanges and clearing houses, including ICE Futures Europe, ICE Futures U.S., and the New York Stock Exchange.

    Benchmark Mineral Intelligence is the independent data provider for the lithium‑ion battery and energy transition supply chain, publishing daily trade‑verified, IOSCO‑assured price assessments used widely in global physical and financial contracts.

    The BMI futures contract suite includes:

    • Lithium Carbonate CIF Asia (BMI) Future

    • Lithium Hydroxide CIF Asia (BMI) Future

    • Spodumene Concentrate FOB Australia (BMI) Future

    • Cobalt Hydroxide CIF Asia (BMI) Future

    These futures contracts connect transparent price discovery with regulated market infrastructure, enabling effective hedging for the world’s battery metal supply chain.

    Learn more about BMI lithium futures or BMI cobalt futures and start trading today.

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  • Powering Romania’s Nuclear Energy Ambitions

    This expansion is a critical part of Romania’s national energy strategy, which takes a holistic approach to energy security and related economic growth goals. It also aligns with the EU’s clean energy targets for 2030, which include decreasing greenhouse gas emissions by at least 40%.1

    “The construction funded by these two deals is anticipated to do more than increase the plant’s power generation. It is expected to lead to a reduction of up to 10 million tons of greenhouse gas emissions per year,” said Anna-Mariya Duncheva, the client executive for SNN and a member of the J.P. Morgan Investment Banking team in EMEA

    The project has received strong support from the Romanian government and international partners including the United States and Canada. The use of CANDU reactor technology and potential to collaborate with leading nuclear technology firms ensure that innovation, safety, and efficiency are prioritized as the project moves ahead. 

    “It is our objective to deliver safe, available energy as planned, no delays, no cost overruns,” said Cosmin Ghita, chief executive officer at Nuclearelectrica. “This partnership is a recognition of the robustness of both projects and a reconfirmation of the complex role nuclear energy is to play on the long run, which I call trust, and I thank J.P. Morgan and the banking institutions for their professionalism and partnership.”  

    “This deal supports the EU’s wider shift toward renewable energy,” said Milena Grayde, head of investment banking for Romania. “Nuclear provides 9% of the world’s energy2. Currently, SNN meets 20% of electricity demand in Romania through nuclear energy, more than double the global ratio. When both projects are finished, that number is expected to climb to 40%.”

    Emre Tuzun, who leads Central and Eastern European corporate banking, agrees. “This deal not only furthers Romania’s energy independence agenda but also demonstrates our commitment to advancing the EU’s climate objectives and supporting our clients across the region.”

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  • Sequential ICV/IV C7R-GD2 CAR T-Cell Therapy Is Better Tolerated in Pediatric CNS Tumors

    Sequential ICV/IV C7R-GD2 CAR T-Cell Therapy Is Better Tolerated in Pediatric CNS Tumors

    The sequential intracerebroventricular (ICV) and intraventricular (IV) administration of CR7-GD2 CAR T-cell therapy was found to be better tolerated vs concurrent administration in pediatric patients with central nervous system (CNS) tumors, according to data from a phase 1 study (NCT04099797) presented at the 2025 Society of Neuro-Oncology Annual Meeting.1

    During the study, investigators at Baylor College of Medicine in Houston, Texas, evaluated 3 administration techniques for the CR7-GD2 CAR T-cell therapy: IV only; concurrent ICV and IV; and sequential ICV and IV.

    Findings showed that in patients treated with IV-only administration (n = 8) at 10 million cells/m2 (n = 3) or 30 million cells/m2 (n = 6), no dose-limiting toxicities (DLTs) were reported, and instances of tumor inflammation–associated neurotoxicity (TIAN) were low grade, occurring in 7 patients. One patient experienced transient grade 4 cytokine release syndrome (CRS); 5 experienced grade 1 CRS. Among patients treated via IV alone who had preexisting neurological defects (n = 7), 6 achieved clinical improvement, including 2 partial responses on imaging, which 1 patient maintained for more than 2 years.

    ICV/IV Administration of CAR T-Cell Therapy in Pediatric CNS Tumors

    • Sequential ICV and IV administration was found to be better tolerated compared with combined ICV and IV treatment.
    • Two DLTs were reported in the combined administration group vs none in patients given sequential treatment.
    • In the sequential cohort, patients experienced only low-grade TIAN/CRS and had clinical stability.

    In patients who received concurrent ICV/IV administration (n = 3), with doses given 1 week apart, 2 experienced DLTs secondary to grade 3 TIAN, including 1 patient with concurrent grade 3 CRS. These DLTs persisted for several weeks and required intervention with anakinra and dexamethasone. In this group, 1 patient achieved a mixed response with transient clinical improvement and stable disease burden. The remaining 2 patients had clinical and radiographic progression.

    The neurotoxicity observed with concurrent administration prompted investigators to adopt a sequential strategy, with ICV administration given 4 weeks after IV treatment. In patients treated with this strategy (n = 3), treatment was well tolerated for at least 3 cycles each, with no DLTs reported; these patients experienced low-grade TIAN/CRS and clinical stability.

    “While back-to-back ICV/IV dosing resulted in increased toxicity compared [with] IV-only therapy, sequential dosing was better tolerated, potentially indicative of the negative sequelae of compounded inflammation,” lead study author Jasia Mahdi, MD, and colleagues wrote in a poster presentation of the data. Mahdi is a pediatric neurologist and neuro-oncologist, and director of Neuro-Oncology for the Division of Pediatric Neurology at Texas Children’s Hospital, as well as an assistant professor of pediatrics-neurology at Baylor College of Medicine.

    How was the phase 1 study conducted?

    The single-center trial enrolled 2 cohorts of patients between 12 months and 22 years of age.2 The first included patients with histologically confirmed, GD2-expressing or H3K27-altered, diffuse midline glioma (DMG) or high-grade glioma (HGG) that was newly diagnosed, defined as prior to radiographic progression or recurrence; patients with histologically confirmed, GD2-expressing or H3K27-altered, recurrent, refractory, or progressive DMG/HGG; and those with recurrent, refractory, or progressive high-grade CNS tumors with confirmed GD2-expression. Cohort 2 included patients with recurrent, refractory, or progressive pontine HGG with confirmed GD2-expression or H3K27-altered DMG.

    All patients needed to have tumors less than 5 cm in maximum dimension, measurable disease on at least 2 dimensions per MRI, and a Karnofsky/Lansky performance status of at least 50.

    The C7R-GD2 CAR T-cell therapy was administered after lymphodepleting chemotherapy in all arms and cohorts, comprising 2 days of cyclophosphamide and 3 days of fludarabine.1 In patients who received combined dosing, the CAR T-cell therapy was given at 5 x 106 cells/m2 ICV, followed by 15 x 106 cells/m2 IV, then another IV dose at the same level. In the sequential cohort, patients received an IV dose at 10 million cells/m2, followed by an ICV dosing in cycle 2 and beyond, starting at 2 million cells and escalating to 5 million cells.

    In both ICV arms, patients remained for inpatient monitoring for 6 to 10 days, followed by close outpatient follow-up. Disease evaluation occurred at week 6.

    The incidence of DLTs was the trial’s primary end point.2 Response rate was a secondary end point.

    In the combined ICV/IV arm, 1 male patient and 2 female patients had a median age of 15 years (range, 4-17).1 Tumor locations included thalamus and midbrain (n = 1), pons (n = 1), and C1-C7/T1 (n = 1). All had H3K27-altered DMG. Patients had a median time since diagnosis before enrollment of 9.4 months, and they had a median time from the end of radiation to enrollment of 6.5 months. These patients received a median of 1 ICV infusion.

    In the sequential cohort, all 3 patients were male with a median age of 16 years (range, 14-17). Tumor locations comprised the thalamus (n = 2) and the temporal lobe (n = 1). Tumor types included H3K27-altered DMG (n = 2) and H3 wild-type, IDH wild-type diffuse HGG (n = 1). Patients had a median time from diagnosis to enrollment of 7.4 months, and a median time from the end of radiation to enrollment of 2.3 months. This group received a median of 3 ICV infusions.

    What were the toxicity profiles of combined and sequential ICV/IV CAR T-cell therapy administration?

    In the combined ICV/IV arm, adverse effects included CRS (grade 1, n = 2 infusions; grade 3, n = 1 infusion), immune effector cell–associated neurotoxicity syndrome (ICANS; grade 0, n = 3 infusions), and TIAN (grade 1, n = 1 infusion; grade 3, n = 2 infusions). Two patients received tocilizumab (Actemra), and all 3 were given dexamethasone, which continued upon hospital discharge.

    In the sequential group, toxicities included CRS (grade 0, n = 13 infusions; grade 1, n = 3 infusions), ICANS (grade 0, n = 16), and TIAN (grade 0, n = 2 infusions; grade 1, n = 14 infusions). All patients required tocilizumab, but no patients received dexamethasone.

    What was reported from a trial case study?

    Investigators highlighted a 16-year-old male patient with H3K27-altered thalamic and periventricular occipital lobe DMG who underwent 9 cycles of treatment in the sequential ICV/IV arm, including 1 IV infusion and 8 ICV infusions. This patient remained on treatment as of data cutoff, and he has experienced CRS and TIAN at a maximum grade of 1. MRI revealed stable disease, and the patient was also stable on a neurological exam.

    References

    1. Mahdi J, Stuckert A, Tat C, et al. Phase I study of intravenous and intracerebroventricular C7R-GD2.CAR T cell therapy for pediatric central nervous system (CNS) tumors. Presented at 2025 Society of Neuro-Oncology Annual Meeting; November 19-23, 2025; Honolulu, HI. Abstract CTP-07.
    2. C7R-GD2.CAR T cells for patients with GD2-expressing brain tumors (GAIL-B). ClinicalTrials.gov. Updated September 4, 2025. Accessed November 23, 2025. https://clinicaltrials.gov/study/NCT04099797

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  • IMF Executive Board Concludes 2025 Article IV Consultation with Republic of Korea – International Monetary Fund

    1. IMF Executive Board Concludes 2025 Article IV Consultation with Republic of Korea  International Monetary Fund
    2. Korea Institute Projects 1.9% Growth as Domestic Demand Fuels Economy  조선일보
    3. The International Monetary Fund (IMF) advised the Lee Jae-myung government, which has set up a “supe..  매일경제
    4. Korean economy forecast to grow 1.9 percent next year, but exports will slip 0.5 percent: KIET  The Korea Times
    5. [Monetary Policy Committee Poll] ② Expectations for 2% Growth Next Year Rise… “Bank of Korea Likely to Raise Its Forecast”  아시아경제

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  • Advanced Micro Devices, Inc. (AMD)

    Advanced Micro Devices, Inc. (AMD)





    News Highlights:

    • Zyphra ZAYA1 becomes the first large-scale Mixture-of-Experts model trained entirely on AMD Instinct™ MI300X GPUs, AMD Pensando™ networking and ROCm open software.
    • ZAYA1-base outperforms Llama-3-8B and OLMoE across multiple benchmarks and rivals the performance of Qwen3-4B and Gemma3-12B.
    • Memory capacity of AMD Instinct MI300X helped Zyphra simplify its training capabilities, while achieving 10x faster model save times.

    SANTA CLARA, Calif., Nov. 24, 2025 (GLOBE NEWSWIRE) — AMD (NASDAQ: AMD) announced that Zyphra has achieved a major milestone in large-scale AI model training with the development of ZAYA1, the first large-scale Mixture-of-Experts (MoE) foundation model trained using an AMD GPU and networking platform. Using AMD Instinct™ MI300X GPUs and AMD Pensando™ networking and enabled by the AMD ROCm™ open software stack, the achievement is detailed in a Zyphra technical report published today.

    Results from Zyphra show that the model delivers competitive or superior performance to leading open models across reasoning, mathematics, and coding benchmarks—demonstrating the scalability and efficiency of AMD Instinct GPUs for production-scale AI workloads.

    “AMD leadership in accelerated computing is empowering innovators like Zyphra to push the boundaries of what’s possible in AI,” said Emad Barsoum, corporate vice president of AI and engineering, Artificial Intelligence Group, AMD. “This milestone showcases the power and flexibility of AMD Instinct GPUs and Pensando networking for training complex, large-scale models.”

    “Efficiency has always been a core guiding principle at Zyphra. It shapes how we design model architectures, develop algorithms for training and inference, and choose the hardware with the best price-performance to deliver frontier intelligence to our customers,” said Krithik Puthalath, CEO of Zyphra. “ZAYA1 reflects this philosophy and we are thrilled to be the first company to demonstrate large-scale training on an AMD platform. Our results highlight the power of co-designing model architectures with silicon and systems, and we’re excited to deepen our collaboration with AMD and IBM as we build the next generation of advanced multimodal foundation models.”

    Efficient Training at Scale, Powered by AMD Instinct GPUs
    The AMD Instinct MI300X GPU’s 192 GB of high-bandwidth memory enabled efficient large-scale training, avoiding costly expert or tensor sharding, which reduced complexity and improving throughput across the full model stack. Zyphra also reported more than 10x faster model save times using AMD optimized distributed I/O, further enhancing training reliability and efficiency. With only a fraction of the active parameters, ZAYA1-Base (8.3B total, 760M active) matches or exceeds the performance of models such as Qwen3-4B (Alibaba), Gemma3-12B (Google), Llama-3-8B (Meta), and OLMoE.1

    Building on prior collaborative work, Zyphra worked closely with AMD and IBM to design and deploy a large-scale training cluster powered by AMD Instinct™ GPUs with AMD Pensando™ networking interconnect. The jointly engineered AMD and IBM system, announced earlier this quarter, combines AMD Instinct™ MI300X GPUs with IBM Cloud’s high-performance fabric and storage architecture, providing the foundation for ZAYA1’s large-scale pretraining.

    For further details on the results, read the Zyphra technical report, the Zyphra blog, and the AMD blog, for comprehensive overviews of the ZAYA1 model architecture, training methodology, and the AMD technologies that enabled its development.

    Supporting Resources

    About AMD
    For more than 50 years AMD has driven innovation in high-performance computing, graphics, and visualization technologies. Billions of people, leading Fortune 500 businesses, and cutting-edge scientific research institutions around the world rely on AMD technology daily to improve how they live, work, and play. AMD employees are focused on building leadership high-performance and adaptive products that push the boundaries of what is possible. For more information about how AMD is enabling today and inspiring tomorrow, visit the AMD (NASDAQ: AMD) website, blog, LinkedIn, and X pages.

    Contact:
    David Szabados
     AMD Communications
    +1 408-472-2439
    david.szabados@amd.com

    Liz Stine
    AMD Investor Relations
    +1 720-652-3965 
    liz.stine@amd.com

    _________________________
    1 Testing by Zyphra as of November 14, 2025, measuring the aggregate throughput of training iterations across the full Zyphra cluster measured in quadrillion floating point operations per second (PFLOPs). The workload was training a model comprised of a set of subsequent MLPs in BFLOAT16 across the full cluster of (128) compute nodes, each containing (8) AMD Instinct™ MI300X GPUs and (8) Pensando™ Pollara 400 Interconnects running a proprietary training stack created by Zyphra. Server manufacturers may vary configurations, yielding different results. Performance may vary based on use of the latest drivers and optimizations. This benchmark was collected with AMD ROCm 6.4.

    Source: Advanced Micro Devices, Inc.


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  • Intuit SMB MediaLabs Audiences Now Available on The Trade Desk Platform, Connecting Advertisers With Small and Mid-Market Businesses :: Intuit Inc. (INTU)

    Intuit SMB MediaLabs Audiences Now Available on The Trade Desk Platform, Connecting Advertisers With Small and Mid-Market Businesses :: Intuit Inc. (INTU)





    Intuit SMB MediaLabs’ latest expansion enables more advertisers to reach small and mid-market businesses with greater precision and relevance

    MOUNTAIN VIEW, Calif.–(BUSINESS WIRE)–
    Intuit Inc., the global financial technology platform that makes TurboTax, Credit Karma, QuickBooks, and Mailchimp, today announced that its SMB MediaLabs audiences are now available on The Trade Desk, providing advertisers with access to Intuit’s first-party small and mid-market business (SMB) audience segments. The partnership facilitates advertisers’ access to Intuit’s SMB MediaLabs, a first-of-its-kind advertising network powered by Intuit’s unmatched first-party business data, through The Trade Desk platform. With this integration, advertisers can seamlessly activate Intuit’s unique small and mid-market business insights to reach SMBs with greater precision and at scale, providing them with highly relevant advertising that connects them with products and services that can help optimize and grow their business. Advertisers will continue to abide by Intuit’s Advertising Guidelines, allowing campaigns to deliver value to Intuit’s SMB customers while adhering to responsible, privacy-conscious standards.

    Small businesses make up 99% of companies in the U.S.1, making the owners and decision-makers of these businesses a high-value market segment with significant spending power. However, this audience has historically been difficult for advertisers to reach accurately, with campaigns often reliant on fragmented or outdated third-party data, resulting in both wasted ad spend for brands and irrelevant experiences for SMBs. The launch of this integration significantly changes this dynamic, making Intuit’s network of unique audiences, which spans millions of SMBs, more readily accessible to advertisers on The Trade Desk platform. Using aggregated, de-identified insights from the Intuit platform, advertisers can more efficiently connect with verified SMB decision-makers, helping brands improve campaign performance while also delivering more relevant ad experiences for SMBs, to help their businesses grow and thrive.

    “This partnership marks a fundamental shift in how B2B marketers will be able to engage small and mid-market businesses. For too long, the industry has struggled with accuracy and relevance in targeting the SMB audience—a critical gap we are now closing,” said Christopher Moneta, Director, SMB MediaLabs, Intuit. “By fusing Intuit’s unique, deterministic SMB insights with the powerful execution capabilities of The Trade Desk, we are setting a new standard. Brands can now confidently deliver highly relevant advertising that reaches the right decision-makers across every channel, while SMBs can more easily discover the products and solutions they need to succeed.”

    The Trade Desk is the latest demand-side platform (DSP) to directly partner with the Intuit SMB MediaLabs network, and the first DSP where this first-party SMB data will be discoverable for advertisers, providing them with efficient campaign management capabilities and improved cross-channel measurement. Available through the SMB MediaLabs self-service offerings as an endpoint on the LiveRamp Data Marketplace, the integration also significantly expands the reach of Intuit’s SMB MediaLabs across connected TV, audio, display, and digital out-of-home channels.

    “As the first media-buying platform to bring Intuit’s SMB MediaLabs audiences to market discoverably, we’re giving advertisers direct access to one of the most trusted sources of small business intelligence,” said Matthew Fantazier, VP, Data Partnerships, The Trade Desk. “This partnership enables us to help brands connect their messages to real decision-makers, with more precision, transparency, and scale.”

    Launched in 2023, Intuit’s SMB MediaLabs allows advertisers to create targeted campaigns that have the potential to reach millions of small and mid-market businesses. Access to this key audience has proven to be game changer for marketers seeking to connect with decision-makers and drive measurable business outcomes.

    For more information, visit medialabs.intuit.com and thetradedesk.com.

    About Intuit

    Intuit is the global financial technology platform that powers prosperity for the people and communities we serve. With approximately 100 million customers worldwide using products such as TurboTax, Credit Karma, QuickBooks, and Mailchimp, we believe that everyone should have the opportunity to prosper. We never stop working to find new, innovative ways to make that possible. Please visit us at Intuit.com and find us on social for the latest information about Intuit and our products and services.

    1 According to a report from the U.S. Small Business Administration, published in July 2024.

    Intuit Media Contact:

    Jaymie Sinlao

    jaymie_sinlao@intuit.com

    Source: Intuit Inc.

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  • Novo Nordisk says Alzheimer's drug trial fails, hammering shares – Reuters

    1. Novo Nordisk says Alzheimer’s drug trial fails, hammering shares  Reuters
    2. Novo Nordisk shares plunge 9% after Alzheimer’s drug trial fails to hit key target  CNBC
    3. Novo Nordisk’s semaglutide fails to slow Alzheimer’s progression  statnews.com
    4. Can Novo unravel Lilly rally with Alzheimer’s data for GLP-1  Seeking Alpha
    5. Stock Market Today: Futures Tip Up to Start Week; Novo Nordisk Plummets After Ozempic Alzheimer’s Miss  TheStreet

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