Category: 3. Business

  • Assessing Valuation After Phase 3 Trial Failure and Major Business Overhaul

    Assessing Valuation After Phase 3 Trial Failure and Major Business Overhaul

    Alector (ALEC) recently reported that its experimental therapy latozinemab did not meet the main efficacy goal in a late-stage trial for frontotemporal dementia. As a result, multiple follow-up studies are being discontinued, and the company is reorganizing its operations.

    See our latest analysis for Alector.

    It has been a dramatic stretch for Alector’s stock. Following news of the Phase 3 trial setback and sweeping operational changes, the one-week share price return plunged by over 50%, and the one-month figure sits at -52.5%. Even before this, momentum had been fading; the 1-year total shareholder return is down 68%, highlighting ongoing challenges for both short- and long-term holders despite a small rebound in the most recent session.

    If unexpected biotech moves get you thinking about where the next big story could emerge, this is a great moment to discover fast growing stocks with high insider ownership

    With steep losses already reflected in Alector’s share price, the key question is whether the market has overreacted and created a bargain, or if the valuation now fairly accounts for fading prospects and future uncertainty.

    Alector’s widely followed narrative suggests a fair value notably above the latest $1.50 close, which hints at market pessimism that may be overdone. The most influential argument highlights the importance of pivotal data still to come and the company’s unique approach, setting up a fascinating debate over potential upside versus recent setbacks.

    Alector’s proprietary expertise and platform for blood-brain barrier delivery of large therapeutic molecules addresses a critical bottleneck in CNS drug development and enables pipeline programs targeting Alzheimer’s, Parkinson’s, and additional neurodegenerative diseases. This lays the groundwork for sustained long-term revenue growth and enhanced gross margins if these programs advance.

    Read the complete narrative.

    What is the secret ingredient inside this valuation? The narrative banks on aggressive revenue acceleration and a total earnings turnaround. Does the fair value truly reflect high expectations for scientific breakthroughs and blockbuster partnerships? Readers with an eye for bold forecasts will want to see the numbers driving this price call.

    Result: Fair Value of $2.20 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, if regulatory hurdles grow or development setbacks persist, confidence in Alector’s ambitious turnaround narrative could quickly begin to unravel.

    Find out about the key risks to this Alector narrative.

    If this story does not match your perspective, or if you would rather investigate the numbers directly, you can craft your own assessment in just a few minutes. Do it your way

    A great starting point for your Alector research is our analysis highlighting 1 key reward and 3 important warning signs that could impact your investment decision.

    Expand your horizons and go beyond the headlines. Thousands of investors are already scouting new opportunities you might be missing right now. Take charge of your investing strategy and gain the edge you deserve by checking out these unique opportunities:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include ALEC.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Can Schrödinger (SDGR) Sustain Its AI Edge in Drug Discovery as Q3 Results Approach?

    Can Schrödinger (SDGR) Sustain Its AI Edge in Drug Discovery as Q3 Results Approach?

    • Schrödinger announced it will release its third quarter 2025 financial results on November 5, 2025, followed by a live webcast and conference call for investors.

    • The company has attracted increasing industry attention as a pioneer in applying artificial intelligence to accelerate drug discovery and reshape biotechnology innovation.

    • We’ll explore how recognition of Schrödinger’s AI leadership amid growing sector focus may influence its long-term investment outlook.

    Find companies with promising cash flow potential yet trading below their fair value.

    To be a shareholder of Schrödinger, you need to believe the company’s AI-driven software can become essential to drug discovery, leading to scalable, recurring revenues and clinical milestones. The upcoming third quarter 2025 results announcement and investor call, while relevant for short-term sentiment, does not materially change the main near-term catalyst, new clinical data for SGR-1505, nor does it resolve the biggest risk of sluggish new client acquisition amid biotech sector headwinds.

    The most closely related recent announcement is Schrödinger’s update on initial clinical results for SGR-1505, a MALT1 inhibitor, which showed early efficacy and received FDA Fast Track designation this June. This progress in the clinic positions SGR-1505 as a primary driver for milestone payments and licensing, supporting management’s focus on revenue growth from drug discovery and anchoring the short-term investment outlook.

    However, investors should also be mindful that, in contrast to the excitement around new clinical milestones, ongoing challenges in expanding the customer base persist and…

    Read the full narrative on Schrödinger (it’s free!)

    Schrödinger’s narrative projects $396.6 million revenue and $34.8 million earnings by 2028. This requires 18.6% yearly revenue growth and a $216.1 million increase in earnings from the current level of -$181.3 million.

    Uncover how Schrödinger’s forecasts yield a $27.30 fair value, a 21% upside to its current price.

    SDGR Community Fair Values as at Oct 2025

    Six independent valuations from the Simply Wall St Community place fair value for Schrödinger between US$27.00 and US$43.20 per share. While some see upside, many remain focused on the risk that slow new client acquisition could constrain long-term revenue growth and influence market sentiment ahead of earnings; explore the range of outlooks shaping this debate.

    Explore 6 other fair value estimates on Schrödinger – why the stock might be worth as much as 92% more than the current price!

    Disagree with existing narratives? Create your own in under 3 minutes – extraordinary investment returns rarely come from following the herd.

    Don’t miss your shot at the next 10-bagger. Our latest stock picks just dropped:

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include SDGR.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • A Fresh Look at Valuation After Sector Jitters Triggered by Texas Instruments Forecast

    A Fresh Look at Valuation After Sector Jitters Triggered by Texas Instruments Forecast

    Shares of Skyworks Solutions (SWKS) slipped 3% after a disappointing outlook from Texas Instruments. This development heightened concerns about a slowing recovery across the broader semiconductor industry and cast a shadow over sector performance.

    See our latest analysis for Skyworks Solutions.

    Against the backdrop of sector-wide jitters sparked by Texas Instruments’ outlook, Skyworks Solutions’ share price has lost ground this month and year-to-date, with a 1-year total shareholder return of -19%. While the company continues to roll out technical advances and earn industry recognition, recent momentum is clearly fading as investors reassess risk across the entire semiconductor space.

    Curious to see which other chipmakers might be showing resilience or fresh growth? You can spot new opportunities with our tech and AI stocks screener using See the full list for free.

    With shares now trading well below their five-year highs and sentiment at a low, the crucial question for investors is whether Skyworks Solutions is an undervalued opportunity or if the market is accurately pricing in future challenges and limited growth ahead.

    Skyworks Solutions’ last close of $74.04 stands slightly above the most-followed narrative’s fair value calculation of $72.47. Analyst consensus believes that near-term improvements may be limited, which sets the stage for ongoing debate around whether today’s market price is justified or too optimistic.

    Accelerated adoption of advanced wireless standards and AI-capable smartphones is increasing the RF content required per device. This positions Skyworks to benefit from higher average selling prices and potential unit volume growth, and may drive revenue and gross margin expansion.

    Read the complete narrative.

    What forecast is powering this valuation? The narrative quietly hinges on a projected turnaround in profit margins, a wave of new revenue sources, and bold expectations for industry cycles. The real surprise is how consensus thinks Skyworks will overcome recent headwinds. Wonder what hidden lever is at the core? Explore the full story to see which future assumptions could send shares in either direction.

    Result: Fair Value of $72.47 (OVERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, risks remain, such as Skyworks’ reliance on a single major customer and persistent competition. Either factor could challenge even the most optimistic scenario.

    Find out about the key risks to this Skyworks Solutions narrative.

    While the analyst consensus suggests Skyworks Solutions is fairly valued or slightly overvalued using market multiples, our DCF model tells a different story. The SWS DCF model estimates fair value at $110.36 per share, which is far above today’s price. This hints at a meaningful undervaluation the market could be overlooking. Can this gap persist, or will investors eventually close it?

    Look into how the SWS DCF model arrives at its fair value.

    SWKS Discounted Cash Flow as at Oct 2025

    If you see things differently, or want to bring your own perspective to the numbers, crafting your own narrative takes just a few minutes. Do it your way

    A great starting point for your Skyworks Solutions research is our analysis highlighting 2 key rewards and 3 important warning signs that could impact your investment decision.

    Take action now and supercharge your watchlist by targeting untapped markets, growth leaders, or stable income opportunities before the crowd catches on.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include SWKS.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Evaluating Whether Shares Are Undervalued After Recent Shift in Market Sentiment

    Evaluating Whether Shares Are Undervalued After Recent Shift in Market Sentiment

    QuidelOrtho (QDEL) has been navigating a challenging market in recent months, facing headwinds that have impacted its share price. Recent performance offers investors reason to revisit the company’s fundamentals as they evaluate longer-term prospects.

    See our latest analysis for QuidelOrtho.

    QuidelOrtho’s 14% share price gain over the past month hints at shifting market sentiment; however, the bigger picture remains challenging given a 1-year total shareholder return of -21% and a steep three-year loss. While momentum has picked up recently, long-term holders are still waiting for a meaningful turnaround.

    If you’re considering what else is out there in healthcare, take this as your cue to discover See the full list for free.

    With shares trading at a hefty discount to analyst price targets, but longer-term returns still deeply negative, investors have to ask whether QuidelOrtho is undervalued at current levels or if the market is already accounting for any future growth potential.

    With QuidelOrtho’s fair value calculation at $40.33 and a last close of $30.51, the narrative suggests there’s significant upside potential if the company meets its projected milestones. Here’s a core insight from the most widely followed narrative driving this view.

    Acquisition of LEX Diagnostics and the planned commercialization of its rapid molecular point-of-care platform addresses the trend toward fast, decentralized testing and is likely to increase recurring revenues and enhance margins as high-value, high-velocity diagnostic solutions become more prevalent.

    Read the complete narrative.

    Curious what numbers could justify this big premium? The full narrative lays out a bold path that includes profitability targets and a future multiple that is out of step with today’s reality. Don’t miss the surprising projections and assumptions that power this price target.

    Result: Fair Value of $40.33 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, persistent declines in COVID-related revenues and challenges from discontinued product lines could undermine near-term gains. These factors may test the company’s turnaround narrative.

    Find out about the key risks to this QuidelOrtho narrative.

    If you see the numbers differently or want to shape your own perspective, you can dive into the data and build your own narrative in just a few minutes. Do it your way

    A great starting point for your QuidelOrtho research is our analysis highlighting 3 key rewards and 1 important warning sign that could impact your investment decision.

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    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include QDEL.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Leading firms are falling behind in developing East Asia

    Advances in transport and communication technologies in the 1980s and 1990s allowed the proliferation of global value chains that spurred the East Asian growth miracle (Baldwin 2016, Williamson and O’Rourke 2017).  Recent decades have seen a new wave of disruptive technologies like robots, AI and digital platforms. Yet, this period has coincided with a deceleration in East Asian productivity (‘total factor productivity’) growth.

    While this productivity slowdown has been global, it is far from uniform. In OECD economies, the top-performing firms – often referred to as the ‘global frontier’ – have maintained rapid productivity growth. The overall slowdown in OECD economies comes from a growing gap between these leaders and the rest (Blanchenay et al. 2017, Criscuolo et al. 2017).  What remains less understood is how these dynamics play out in emerging economies.

    Frontier firms in East Asia are falling behind

    Why has this productivity slowdown in East Asia come at a time of rapid technological progress?  To address this question, in De Nicola et al. (2025) we use newly harmonised firm-level data from national statistical agencies across five major East Asian economies.

    First, in East Asia, around three quarters of aggregate productivity growth has been due to increases within existing firms.  Very little is contributed to productivity growth by the reallocation of market share across firms or from firm entry and exit.  In fact, the market share of the national frontier firms – the 10% most productive firms in a sector – is declining.  Resources appear to be trapped in less-productive firms that should shrink or exit, which could enable more-productive firms to scale up.

    Second, productivity growth within the national frontier firms has been slower than among less productive firms. Frontier firms account for a large share of output and employment and around half of all within-firm productivity growth, so their stagnation weighs heavily on overall productivity.

    While slower growth relative to less productive firms may reflect desirable domestic convergence, productivity gaps between East Asia’s frontier firms and the global frontier are widening in digital-intensive sectors — such as electronics, IT services, and pharmaceuticals. Between 2005 and 2015, global frontier firms in digital manufacturing boosted productivity by 76%. In contrast, national frontier firms in Indonesia, Malaysia, the Philippines, and Viet Nam achieved only a 34% increase over the same period (refer to Figure 1).

    One reason for the underperformance of leading firms in East Asia is the uneven adoption of advanced technology. The gap in technology use between firms in East Asia and Pacific (EAP) and the world’s most sophisticated firms has widened, much more so than the gap between the average EAP firms and their global counterparts. The diffusion of accessible technologies like mobile internet is almost universal, whereas big differences persist for sophisticated technologies that drive frontier firm growth.

    Figure 1 The national frontier in EAP countries is falling behind the global frontier, especially in digital sectors

    Note: “National frontier” refers to the 90th percentile of the firm productivity distribution for each country and industry and “global frontier” to the 95th percentile of the firm productivity distribution across high-income economies within an industry.  The distance between the national and global frontier productivity is normalized to 0 in the first year, such that negative numbers reflect the national frontier falling further behind the global frontier relative to the first year, and positive numbers reflect the national frontier catching up with or exceeding the global frontier. Sector “digital intensity” is defined according to Eurostat’s Digital Intensity Index, which classifies high-technology manufacturing and high-knowledge-intensive services as “digital-intensive sectors” and other manufacturing and services sectors as “less-digital-intensive sectors.” CHN = China; IDN = Indonesia; MYS = Malaysia; PHL = Philippines; VNM = Viet Nam.

    Why are the leaders not leading? How can policy help?

    The relative stagnation of East Asia’s top firms may be because they lack adequate competition incentives and the relevant capabilities, such as high-quality skills and infrastructure.

    1 Firms need stronger incentives

    Barriers to competition in both goods and services markets stifle the incentive for the top firms to innovate. Firms that are close to the frontier innovate to stay ahead of their competitors, whereas laggard firms are discouraged and innovate less (Aghion et al. 2021).  For example, Chinese import competition has been found to increase the innovation of leading firms but to depress it among nonleading firms in several countries (Cusolito et al. 2021, Iacovone 2012).

    Although tariffs on goods are relatively low in East Asia, non-tariff measures in manufacturing and restrictions on services limit competition. For instance, in sectors dominated by state-owned enterprises (SOEs), frontier firm productivity growth is significantly lower than in other sectors.

    Policy reforms that increase exposure to competition can be powerful tools to accelerate productivity growth. For example, liberalisation of services markets following Viet Nam’s WTO accession in 2007 are associated with 5% faster productivity growth of frontier firms in these same services sectors and over 10% in downstream manufacturing firms that use these services (see Figure 2).

    Figure 2 Opening services to competition in Viet Nam increased productivity in these services sectors as well as in downstream manufacturing sectors that use services inputs

    Note: The figure presents within-firms estimates of changes in total factor productivity between 2008 and 2016 and changes in the STRI of the World Bank and World Trade Organization. Coefficients reflect the estimated increase in productivity for a 1 standard deviation decrease in STRI. All coefficients are statistically significant at the 95 percent level. “Frontier firms” are defined as the top 10 percent most-productive firms within an industry, and “laggard firms” are the bottom 10 percent. The main explanatory variable is the change in STRI values in the trade, transport, finance, professionals, and telecommunications sectors between 2016 and 2008 in the “direct own-sector effect,” and the change in the “downstream” STRI for manufacturing sectors in “downstream effect.” The downstream STRI is a sector-specific measure for each two-digit manufacturing sector, calculated by the average STRI of the 5 services sectors, weighted by the corresponding purchasing value from each manufacturing sector. The regression sample in “direct own-sector effect” consists of all enterprises operating in the trade, transport, finance, professionals, and telecommunications sectors, and all manufacturing enterprises in “downstream effect,” in 2008 and 2016. STRI = Services Trade Restrictions Index.

    2 Firms need stronger capabilities

    Productivity growth and adoption of sophisticated technologies require a broad range of skills and high-quality digital infrastructure. Yet basic skills remain limited. In several East Asian economies, more than half of 10-year-olds are unable to read an age-appropriate passage. Management quality remains a challenge, with the best-managed firms in the region especially far behind the best-managed firms globally. Meanwhile, access to high-speed fibre broadband – critical for cloud-based tools and AI – is uneven across and within countries.

    Improving skills is key.  Reforms are needed to fix the foundation of basic skills on which more-advanced skills can be built. Equipping workers with the skills that complement new technologies and enhancing the abilities of managers are crucial to accelerating productivity (Arias et al. 2025).  Increased investment in new technologies is correlated with higher firm productivity in Viet Nam, but only for firms with a sufficiently skilled workforce (see Figure 3). 

    Figure 3 Productivity gains from technology adoption accrue to firms with more-skilled workers

    Note: The figure presents results from an estimation of within-firm changes in TFP on changes in the (log) value of a firm’s primary production technology per worker, interacted with a skills quartile dummy. Based on 2010–18 firm-level data for Viet Nam. Skills are measured in the initial period and reflect the share of a firm’s workers with a university degree, and quartiles are calculated within a two-digit industry. Error bars denote 90 percent confidence intervals; hence, the coefficients on the bottom skill quartile are not significantly different from zero. TFP = total factor productivity.

    3 The case for coordinated reforms

    Boosting productivity at the frontier requires a package of mutually reinforcing reforms: enhancing competition by liberalising services and reducing non-tariff barriers; building skills, from foundational literacy to advanced technical and managerial capabilities; and expanding digital infrastructure, thus ensuring access to high-speed internet and cloud services.

    Synchronizing reforms can help exploit the synergies between enhanced human capital, infrastructure, and competition.  For example, both openness to foreign competition and access to fibre broadband for firms in the Philippines increased technology adoption, but their combined impact was more than double. Similarly, widening access to higher education in China increased productivity, especially for foreign-owned firms. Also, trade liberalization in Indonesia led to productivity-enhancing increases in foreign direct investment, especially for firms with more-skilled workforces.

    Conclusions

    The relative stagnation of East Asia’s frontier firms is a challenge for long-term growth. In a world of accelerating technological change, maintaining competitiveness requires more than broad access to digital infrastructure. It requires ensuring that the most productive firms can innovate, expand, and adopt cutting-edge technologies. Our findings call for coordinated reforms – in skills, infrastructure, and competition – that can unleash the potential of East Asian firms and ensure they keep pace with the best in the world.

    Authors’ note: The opinions expressed in this column are entirely those of the authors. They do not necessarily represent the views of the International Bank for Reconstruction and Development/World Bank and its affiliated organisations, or those of the Executive Directors of the World Bank or the governments they represent.

    References

    Arias, O, D Fukuzawa, D Le and A Mattoo (2025), “Future jobs: AI, robots, and jobs in developing countries”, VoxEU.org, 30 August.

    Aghion, P, C Antonin, and S Bunel (202a), The Power of Creative Destruction: Economic Upheaval and the Wealth of Nations, Harvard University Press.

    Baldwin, R (2016), The Great Convergence: Information Technology and the New Globalization, Harvard University Press.

    Blanchenay, P, C Criscuolo, and G Berlingieri (2017), “Great Divergences: The growing dispersion of wages and productivity in OECD countries”, VoxEU.org, 15 May.

    Cusolito, A P, A Garcia-Marin, and W F Maloney (2021), “Proximity to the frontier, markups, and the response of innovation to foreign competition”, VoxEU.org, 4 November.

    Criscuolo, C, P Gal, and D Andrews (2017), “The best vs the rest: The global productivity slowdown hides an increasing performance gap across firms”, VoxEU.org, 27 March.

    De Nicola, F, A Mattoo, and J Timmis (2025), Firm Foundations of Growth: Productivity and Technology in East Asia and Pacific, East Asia and Pacific Development Studies, World Bank.

    Iacovone, L (2012), “The Better You Are, The Stronger It Makes You: Evidence on the Asymmetric Impact of Liberalization”, Journal of Development Economics 99(2): 474–85

    Williamson, J G and K O’Rourke (2017), “The spread of modern manufacturing to the poor periphery”, VoxEU.org, 3 April.

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  • Tax rises could push food prices higher, warn supermarkets

    Tax rises could push food prices higher, warn supermarkets

    [Getty Images]

    The bosses of Britain’s biggest supermarkets have warned food prices could rise even further if higher taxes are imposed on the sector.

    Grocers including Tesco, Asda, Sainsbury’s and Morrisons signed a letter to Chancellor Rachel Reeves ahead of her Budget next month, along with Lidl, Aldi, Iceland, Waitrose and M&S.

    They claimed households would “inevitably feel the impact” of any potential tax increases on the industry, such as higher business rates for supermarkets.

    The Treasury said tackling food price inflation was a “priority” and said it was lowering business rates for “butchers, bakers and other shops”.

    In their letter to the Chancellor, supermarket bosses said if the industry was to face higher taxes, “our ability to deliver value for our customers will become even more challenging and it will be households who inevitably feel the impact”.

    “Given the costs currently falling on the industry, including from the last Budget, high food inflation is likely to persist into 2026,” they warned.

    “This is not something that we would want to see prolonged by any measure in the Budget.”

    Ahead of the chancellor’s Autumn Budget next month, speculation is growing over her tax and spending policies.

    She is widely expected to increase taxes following gloomy economic forecasts and a series of U-turns on cuts to welfare spending, which have made it more difficult for her to meet her self-imposed borrowing rules.

    After announcing tax rises of £40bn in her previous Budget in November, which included a hike in the amount employers are required to pay in National Insurance Contributions, Reeves said she was “not coming back” for more tax rises.

    But economists at the influential Institute for Fiscal Studies (IFS) have calculated a shortfall of £22bn in the public finances and suggested Reeves will “almost certainly” have to raise taxes.

    The think tank cited rising borrowing costs for the government, weaker growth forecasts, and spending commitments made since the spring as reasons for the tight position.

    Many industries in the run-up to the Budget often call on and lobby their views and position to the government, but rising food prices are once again putting pressure on people’s finances.

    The cost of many staples has spiked compared with butter prices up by 19% and milk over 12% along with chocolate and coffee rising 15%, according to the Office for National Statistics.

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  • Left Distal Radial Access Doesn’t Reduce Radiation for Operators: DOSE

    Left Distal Radial Access Doesn’t Reduce Radiation for Operators: DOSE

    Researchers hoped the technique might involve lower exposure compared with right transradial access, but this didn’t pan out.

    SAN FRANCISCO, CA—Operators are exposed to equal amounts of radiation during coronary procedures whether they use left distal radial access (DRA) or right transradial access (TRA), according to new data from the randomized, multicenter DOSE trial.

    Yongcheol Kim, MD, PhD (Yongin Severance Hospital, Republic of Korea), who presented the data during the TCT WorldLink Forum today, said left DRA “has recently emerged as an alternative access site” that, among other things, offers operators less physical discomfort. It also involves less subclavian tortuosity plus catheter techniques that are more akin to the transfemoral approach.

    Unfortunately, as in the group’s previous DRAMI trial comparing access routes in STEMI patients, the hoped-for radiation benefits with left DRA did not pan out.

    James Goldstein, MD (Millennium Cardiology, Royal Oak, MI), the discussant following Kim’s presentation, summed up the data by saying: “I love it when trials make sense.” In DOSE, “the manner in which the left and right wrists were ultimately positioned [was] pretty much the same spot on the groin, so there’s no a priori reason to think there would be much difference in radiation exposure based on the position and the access,” he commented.

    Led by Oh-Hyun Lee, MD, and Ji Woong Roh, MD, PhD (both from Yongin Severance Hospital), the study, which was simultaneously published in JACC: Cardiovascular Interventions, is the first large, randomized trial to evaluate the potential for left DRA to limit how much radiation operators receive during these procedures. 

    Prior studies had suggested that “operators using the left TRA tend to experience less radiation exposure than those using the right TRA,” according to Kim.

    “Coronary angiography and PCI are essential procedures in the diagnosis and treatment of coronary artery disease, often performed thousands of times over an interventional cardiologist’s career,” the researchers note in their paper, adding that the radiation exposure to operators that accompanies such cases can, over a lifetime, pose substantial health risks.

    The DOSE Trial

    The DOSE investigators randomized 1,010 patients scheduled to undergo coronary procedures by either left DRA or right TRA at three centers in the Republic of Korea. They used a set of three real-time dosimeters to measure radiation exposure for five experienced operators at the left wrist, as well as at the left side of the head outside the lead cap and the left chest pocket of the lead vest. All wore the same radiation protection gear, including lead skirt and vests, thyroid collars, leaded glasses, leaded caps, and shields mounted on the table and ceiling.

    With left DRA, patients’ left hands were positioned in the same place as where the left femoral artery puncture site would be, whereas with right TRA, patients’ right arms were positioned close to the right side of their bodies.

    The left DRA group had a lower proportion of male patients and was more likely to undergo ultrasound-guided puncture. PCI, done in a quarter of the participants, trended higher with left DRA but didn’t reach statistical significance. All other baseline characteristics were similar in the two groups.

    However, radiation levels were similar at each location no matter which access route was used.

    Median Radiation Exposure (μSv) to Operators by Access Route

     

    Left DRA

    Right TRA

    P Value

    Left Wrist

    4.76

    5.20

    0.342

    Head

    2.00

    1.83

    0.416

    Chest

    1.28

    1.07

    0.199

    There were no advantages to either approach for the secondary endpoints of access-site crossover, fluoroscopy time, procedure time, and contrast volume, and no differences across patient subgroups.

    Overall, though, the study reassures “that radiation hazard should not be considered a limiting factor for the adoption of left DRA in routine clinical practice,” the researchers conclude.

    Goldstein added that both access routes were “successful, with equivalent levels of procedural performance,” however.

    Going forward, as radiation protective gear grows more sophisticated and more widely used, these issues may have less relevance, he suggested. The benefits of the newer products go beyond lower exposure to radiation. Also important, Goldstein said, is “getting the lead off and avoiding the orthopedic complications” associated with traditional protective clothing.


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  • Dimeco (DIMC) Profit Margin Beats Narrative With 32.2%, Reinforcing Value Investor Optimism

    Dimeco (DIMC) Profit Margin Beats Narrative With 32.2%, Reinforcing Value Investor Optimism

    Dimeco (DIMC) delivered earnings growth of 6.7% per year over the last five years, with profits accelerating to a strong 36.1% gain in the latest twelve months. Net profit margin improved to 32.2% from 27.6% a year ago, signaling higher earnings quality and operational efficiency. Investors will note not only the company’s expanding profit margins, but also its attractive dividend, solid valuation, and consistently positive profit trajectory, with no major risks flagged in this period.

    See our full analysis for Dimeco.

    Next up, we’ll see how these headline results measure up against the widely held Simply Wall St narratives, spotlighting where the numbers match the market’s expectations and where they could spark new debates.

    Curious how numbers become stories that shape markets? Explore Community Narratives

    OTCPK:DIMC Earnings & Revenue History as at Oct 2025
    • Dimeco trades at $41.25 per share while the DCF fair value stands at $93.21, meaning shares are currently 56% below what the discounted cash flow model suggests they could be worth.

    • Bulls point to this sizable gap as a key opportunity, highlighting that the company’s price-to-earnings ratio is just 6.8x versus the US banks industry average of 11.2x.

      • They argue that such a low multiple, combined with resilient profit margins of 32.2%, significantly supports the bullish case that Dimeco is undervalued both absolutely and relative to peers.

      • Critics may note limited risk disclosures, but value-focused investors see few red flags to challenge the upside implied by the fair value gap.

    • Net profit margin climbed to 32.2%, outshining the previous year’s 27.6% and indicating Dimeco is extracting higher profitability than typical industry rivals.

    • The prevailing market view underscores how this margin strength aligns with past earnings growth of 6.7% per year.

      • What is notable is that the most recent year’s 36.1% profit surge reinforces this operational quality, rather than marking a one-off spike.

      • Combined with limited downside risks and consistent profit trajectory, the margin trend makes bullish arguments more compelling for fundamentals-driven investors.

    • Dimeco’s price-to-earnings ratio of 6.8x sits well below both the peer group average of 9.5x and the sector’s 11.2x, solidifying its profile as a value stock within US banks.

    • The prevailing market view highlights that this relative discount, alongside a history of profit or revenue growth, draws in investors seeking income and upside potential.

      • Not only is the P/E ratio lower, but it comes with a track record of growing profits and an attractive dividend, helping it stand out from pure deep value plays that lack quality.

      • Any debate about slow long-term growth is less pressing when the company has consistently improved margins and payout, according to the financial data presented.

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  • Evaluating Valuation After Annual Profit Jump and Revenue Dip

    Evaluating Valuation After Annual Profit Jump and Revenue Dip

    Fortuna Mining (TSX:FVI) shares edged slightly lower after the company reported a modest annual revenue dip, while net income saw a significant jump. Investors are considering how improved profitability might impact the stock’s valuation moving forward.

    See our latest analysis for Fortuna Mining.

    Fortuna Mining’s run this year has been impressive, with a year-to-date share price return of 73.44 percent and a 1-year total shareholder return of 61.90 percent. This demonstrates clear momentum, even after a short-term pullback. That kind of performance stands out, especially as investors consider recent earnings gains and the company’s improved profitability in the context of broader market trends.

    If you’re keeping an eye out for stocks with breakout momentum or surging fundamentals, this is the perfect time to broaden your perspective and discover fast growing stocks with high insider ownership

    With strong gains this year and analyst targets still above the current share price, some investors are questioning whether Fortuna Mining remains undervalued or if the market has already factored in future growth potential. Is this a real buying opportunity?

    Fortuna Mining’s fair value, according to the most widely followed analyst narrative, comes in at CA$13.65 per share. This is well above the latest close at CA$11.43. This significant gap is catching the attention of investors looking for undervalued opportunities based on strong growth catalysts outlined below.

    Expansion projects and exploration in West Africa and Latin America position Fortuna to boost production, access new revenue streams, and support long-term growth. Operational efficiencies, rising precious metals prices, and improved ESG performance collectively strengthen profitability, reduce risks, and enhance earnings stability.

    Read the complete narrative.

    Want to know why analysts think Fortuna Mining deserves a higher price? The real engine behind this narrative lies in aggressive profit growth and a transformative margin story, but the exact numbers will surprise you. Dig deeper to discover which financial assumptions are fueling this valuation gap.

    Result: Fair Value of $13.65 (UNDERVALUED)

    Have a read of the narrative in full and understand what’s behind the forecasts.

    However, future growth depends heavily on successful project execution and cost management. Any setbacks could potentially jeopardize margins or delay production gains.

    Find out about the key risks to this Fortuna Mining narrative.

    While analysts see Fortuna Mining as significantly undervalued based on future growth estimates, our SWS DCF model comes to a different conclusion. It puts fair value at CA$9.56 per share, which is below the current price. This may indicate possible overvaluation if cash flow assumptions prove too optimistic. Which view will ultimately be right?

    Look into how the SWS DCF model arrives at its fair value.

    FVI Discounted Cash Flow as at Oct 2025

    Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Fortuna Mining for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match – so you never miss a potential opportunity.

    If you see things differently or want to dig into the numbers on your own, you can craft a personalized analysis in just a few minutes with Do it your way.

    A great starting point for your Fortuna Mining research is our analysis highlighting 4 key rewards and 1 important warning sign that could impact your investment decision.

    Why settle for just one opportunity when other standout stocks could be right within reach? Boost your investing edge by screening the market for breakout performers, high potential, or defensive dividend yields you might otherwise overlook.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include FVI.TO.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

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  • Assessing Valuation After Recent Share Price Downtrend

    Assessing Valuation After Recent Share Price Downtrend

    Venture Global (VG) shares have been on the move lately, catching the eye of investors curious about what is driving the change. The stock has dropped about 35% over the past month, drawing attention to recent shifts in sentiment.

    See our latest analysis for Venture Global.

    Looking beyond the past month’s 34.7% slide in share price, Venture Global’s momentum has been fading for most of 2024, with its year-to-date share price return down over 60%. While the latest moves may reflect shifting risk perceptions, it is part of a longer pattern where any short-term rallies have not built into sustained gains.

    If you’re looking to widen your investing lens as market sentiment shifts, this could be the perfect moment to discover fast growing stocks with high insider ownership.

    With shares trailing well below their analyst price targets and annual revenue still showing solid growth, the question now is whether Venture Global is trading at a steep discount or if future prospects are already reflected in the market.

    Venture Global is trading at a price-to-earnings (P/E) ratio of 17.9x. This places it at a premium compared to the industry average and its own fair ratio estimate. With a last close price of $9.49, investors are currently paying more for each dollar of earnings than is typical for similar U.S. oil and gas companies.

    The price-to-earnings ratio captures how much the market is willing to pay for a company’s profits. It is a widely used tool for gauging whether a stock is trading at a reasonable level given its current and future earnings. For Venture Global, this elevated multiple suggests high expectations for profit growth, despite modest near-term earnings estimates and industry headwinds.

    Compared to the U.S. oil and gas industry average P/E of 12.8x, Venture Global appears significantly more expensive. Its ratio also exceeds the estimated fair price-to-earnings level of 14.3x. This valuation gap signals the market may be overpricing future prospects, especially given the company’s current growth and profit profile.

    Explore the SWS fair ratio for Venture Global

    Result: Price-to-Earnings of 17.9x (OVERVALUED)

    However, rising revenue growth could falter if industry conditions worsen or if profit improvements do not keep pace with expectations.

    Find out about the key risks to this Venture Global narrative.

    While the price-to-earnings ratio presents Venture Global as expensive compared to its peers, the SWS DCF model offers a different perspective. According to our DCF model, shares are trading approximately 31.6% below their estimated fair value of $13.88. Could the market be missing long-term fundamentals?

    Look into how the SWS DCF model arrives at its fair value.

    VG Discounted Cash Flow as at Oct 2025

    Simply Wall St performs a discounted cash flow (DCF) on every stock in the world every day (check out Venture Global for example). We show the entire calculation in full. You can track the result in your watchlist or portfolio and be alerted when this changes, or use our stock screener to discover undervalued stocks based on their cash flows. If you save a screener we even alert you when new companies match – so you never miss a potential opportunity.

    If you’d rather form your own view or want to dig deeper into Venture Global’s numbers, you can build your own data-driven story in just a few minutes. Use our tools to do it your way with Do it your way.

    A great starting point for your Venture Global research is our analysis highlighting 2 key rewards and 2 important warning signs that could impact your investment decision.

    Smart investors never settle for just one growth story. Expand your portfolio by checking out these top opportunities that other savvy investors are following right now.

    • Spot game-changing companies building tomorrow’s technology when you browse these 27 AI penny stocks. These organizations are reshaping industries through artificial intelligence and automation.

    • Tap into reliable streams of income by researching these 17 dividend stocks with yields > 3%, which offers attractive yields and proven stability in shifting markets.

    • Ride the momentum of digital innovation as you review these 80 cryptocurrency and blockchain stocks, a driving force behind the rapid evolution of blockchain and cryptocurrency adoption.

    This article by Simply Wall St is general in nature. We provide commentary based on historical data and analyst forecasts only using an unbiased methodology and our articles are not intended to be financial advice. It does not constitute a recommendation to buy or sell any stock, and does not take account of your objectives, or your financial situation. We aim to bring you long-term focused analysis driven by fundamental data. Note that our analysis may not factor in the latest price-sensitive company announcements or qualitative material. Simply Wall St has no position in any stocks mentioned.

    Companies discussed in this article include VG.

    Have feedback on this article? Concerned about the content? Get in touch with us directly. Alternatively, email editorial-team@simplywallst.com

    Continue Reading