Children’s entertainers the Wiggles have admitted to selling headbands to kids without warning about the dangers of button batteries contained within the products.
More than 3,100 Emma Bow headbands, which have four flashing lights powered by button batteries, were sold at live concerts, retailers and online between June 2022 and March 2024.
A legally enforceable undertaking signed by the blue Wiggle, Anthony Field, outlined the Wiggles’ admission that failing to include a headband safety warning likely breached Australian consumer law.
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The yellow and black Emma Bow headbands were recalled in August 2024 by the manufacturer CA Australia over safety concerns for young children who could choke by ingesting the small, shiny batteries.
In a statement by the ACCC on Tuesday, its deputy chair, Catriona Lowe, said button batteries posed a significant risk to young children and mandatory standards were important in helping to prevent injuries.
“Without a warning on the product, parents may not have known it contained button batteries and not understood the severity of the risk,” Lowe said.
“If swallowed, a button battery can become stuck in a child’s throat and result in catastrophic injuries, and even death, in as little as two hours.”
As part of its cooperation with the ACCC’s investigation, the Wiggles committed to produce an episode of its Wiggle Talk podcast discussing safety issues relating to button batteries and children’s toys.
The manufacturer also pledged to improve its compliance with consumer law.
Researchers have previously found approximately 200 children are potentially exposed to button battery injury in Australia each year, and at least a dozen experience severe injury.
The batteries have also been linked to the deaths of three children in Australia, according to the watchdog, in incidents unrelated to the Emma Bow headbands.
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The safety admission is the latest legal trouble for the Wiggles after it was sued by its former CEO Luke O’Neill.
The former boss launched legal action in the federal court in September, arguing he was dismissed without a reasonable basis by the group after complaining about the hiring of Field’s friends and family members.
But the Wiggles denied the allegations and alleged the former CEO was fired because his “overall performance was not satisfactory” and necessary trust in him had been lost.
A settlement was negotiated between both parties in October, news.com.au reported.
Huang Y, Ren J, Qu X. Nanozymes: classification, catalytic mechanisms, activity regulation, and applications. Chem Rev. 2019;119:4357–412. https://doi.org/10.1021/acs.chemrev.8b00672.
Article
PubMed
Google Scholar
Bilal M, Singh AK, Iqbal HMN, Boczkaj G. Enzyme-conjugated MXene nanocomposites for biocatalysis and biosensing. Chem Eng J. 2023;474:145020. https://doi.org/10.1016/j.cej.2023.145020.
Article
Google Scholar
Wu J, Wang X, Wang Q, Lou Z, Li S, Zhu Y, et al. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes (part II). Chem Soc Rev. 2019;48:1004–76. https://doi.org/10.1039/c8cs00457a.
Article
PubMed
Google Scholar
Gao L, Zhuang J, Nie L, Zhang J, Zhang Y, Gu N, et al. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nat Nanotechnol. 2007;2:577–83. https://doi.org/10.1038/nnano.2007.260.
Article
PubMed
Google Scholar
Zhang X, Lin S, Liu S, Tan X, Dai Y, Xia F. Advances in organometallic/organic nanozymes and their applications. Coord Chem Rev. 2021;429:213652. https://doi.org/10.1016/j.ccr.2020.213652.
Article
Google Scholar
Liu Q, Zhang A, Wang R, Zhang Q, Cui D. A review on metal- and metal oxide-based nanozymes: properties, mechanisms, and applications. Nano-Micro Lett. 2021;13:154. https://doi.org/10.1007/s40820-021-00674-8.
Article
Google Scholar
Jiao L, Yan H, Wu Y, Gu W, Zhu C, Du D, et al. When nanozymes meet single-atom catalysis. Angew Chem Int Ed. 2020;59:2565–76. https://doi.org/10.1002/anie.201905645.
Article
Google Scholar
Derry PJ, Liopo AV, Mouli K, McHugh EA, Vo ATT, McKelvey A, et al. Oxidation of hydrogen sulfide to polysulfide and thiosulfate by a carbon nanozyme: therapeutic implications with an emphasis on Down syndrome. Adv Mater. 2023;2211241. https://doi.org/10.1002/adma.202211241.
Article
Google Scholar
Sun Y, Xu B, Pan X, Wang H, Wu Q, Li S, et al. Carbon-based nanozymes: design, catalytic mechanism, and bioapplication. Coord Chem Rev. 2023;475:214896. https://doi.org/10.1016/j.ccr.2022.214896.
Article
Google Scholar
Xu R, Zhang S, Wang P, Zhang R, Lin P, Wang Y, et al. Nanozyme-based strategies for efficient theranostics of brain diseases. Coord Chem Rev. 2024;501:215519. https://doi.org/10.1016/j.ccr.2023.215519.
Article
Google Scholar
Zhang S, Zhang Y, Feng Y, Wu J, Hu Y, Lin L, et al. Biomineralized two-enzyme nanoparticles regulate tumor glycometabolism inducing tumor cell pyroptosis and robust antitumor immunotherapy. Adv Mater. 2022;34:2206851. https://doi.org/10.1002/adma.202206851.
Article
Google Scholar
Song N, Yu Y, Zhang Y, Wang Z, Guo Z, Zhang J, et al. Bioinspired hierarchical self-assembled nanozyme for efficient antibacterial treatment. Adv Mater. 2023;2210455. https://doi.org/10.1002/adma.202210455.
Article
Google Scholar
Molvin J, Jujic A, Holm H, Dieden A, Korduner J, Zaghi A, et al. Selenium deficiency is associated with anemia in heart failure patients – The HARVEST study. Eur Heart J. 2023. https://doi.org/10.1093/eurheartj/ehad655.905.
Jujić A, Melander O, Bergmann A, Hartmann O, Nilsson PM, Bachus E, et al. Selenoprotein p deficiency and risk of mortality and rehospitalization in acute heart failure. J Am Coll Cardiol. 2019;74:1009–11. https://doi.org/10.1016/j.jacc.2019.06.023.
Article
PubMed
Google Scholar
Yang W, Huang G, Chen F, Huang H. Extraction/synthesis and biological activities of selenopolysaccharide. Trends Food Sci Technol. 2021;109:211–8. https://doi.org/10.1016/j.tifs.2021.01.028.
Article
Google Scholar
Uppala PPT, Isaak S, Wong B, Ferreira K, Garberoglio C, Kelly J. Abstract P24: Evidenced-based natural therapies and immune-enhancing strategies to control, prevent, and treat co-morbidities COVID-19 and cancer. Clin Cancer Res. 2021;27:P24–24. https://doi.org/10.1158/1557-3265.covid-19-21-p24.
Article
Google Scholar
Gómez-Gómez B, Fernández-Bautista T, Madrid Y. (Bio)analytical approaches for investigating the role of selenium in preventing neurological disorders and neurotoxicity induced by environmental neurotoxicants: As, Cd, and hg. TRAC Trends Anal Chem. 2024;174:117661. https://doi.org/10.1016/j.trac.2024.117661.
Article
Google Scholar
Weekley CM, Harris HH. Which form is that? The importance of selenium speciation and metabolism in the prevention and treatment of disease. Chem Soc Rev. 2013;42:8870–94. https://doi.org/10.1039/c3cs60272a.
Article
PubMed
Google Scholar
Mertz W. The essential trace elements. Science. 1981;213:1332–8. https://doi.org/10.1126/science.7022654.
Article
PubMed
Google Scholar
Rayman MP. The importance of selenium to human health. Lancet. 2000;356:233–41. https://doi.org/10.1016/s0140-6736(00)02490-9.
Article
PubMed
Google Scholar
Mousa R, Notis Dardashti R, Metanis N. Selenium and selenocysteine in protein chemistry. Angew Chem Int Ed. 2017;56:15818–27. https://doi.org/10.1002/anie.201706876.
Article
Google Scholar
Zhang X-L, Gu Y-Y, Liu Y-C, Cai Y-T, Sun H, Liu Y-X, et al. Near-infrared enhanced organic Se-doped carbon nitride quantum dots nanozymes as SOD/CAT mimics for anti-Parkinson via ROS-NF-κB-NLRP3 inflammasome axis. Chem Eng J. 2024;499:156028. https://doi.org/10.1016/j.cej.2024.156028.
Article
Google Scholar
Cheng J, Li L, Jin D, Zhang Y, Yu W, Yu J, et al. A non-metal single atom nanozyme for cutting off the energy and reducing power of tumors. Angew Chem Int Ed. 2024;63:e202319982. https://doi.org/10.1002/anie.202319982.
Article
Google Scholar
Zhao Y, Xu J, Zhang Y, Wu F, Zhao W, Li R, et al. Biomimetic redox-responsive prodrug micelles with diselenide linkage for platinum nanozymes augmented sonodynamic/chemo combined therapy of colon cancer. Chem Eng J. 2023;472:144911. https://doi.org/10.1016/j.cej.2023.144911.
Article
Google Scholar
Huang X, Liu X, Luo Q, Liu J, Shen J. Artificial selenoenzymes: designed and redesigned. Chem Soc Rev. 2011;40:1171–84. https://doi.org/10.1039/c0cs00046a.
Article
PubMed
Google Scholar
Stolwijk JM, Falls-Hubert KC, Searby CC, Wagner BA, Buettner GR. Simultaneous detection of the enzyme activities of GPx1 and GPx4 guide optimization of selenium in cell biological experiments. Redox Biol. 2020;32:101518. https://doi.org/10.1016/j.redox.2020.101518.
Article
PubMed
PubMed Central
Google Scholar
Kumar A, Dutt R, Srivastava A, Kayastha AM. Immobilization of α-amylase onto functionalized molybdenum diselenide nanoflowers (MoSe2-NFs) as scaffolds: characterization, kinetics, and potential applications in starch-based industries. Food Chem. 2024;442:138431. https://doi.org/10.1016/j.foodchem.2024.138431.
Article
PubMed
Google Scholar
Li N, Liu M, Ma Y, Chang Q, Wang H, Li Y, Zhang H, Liu B, Xue C, Hu S. Molybdenum selenide/porous carbon nanomaterial heterostructures with remarkably enhanced light-boosting peroxidase-like activities. ACS Appl Mater Interfaces. 2021;13:54274–83. https://doi.org/10.1021/acsami.1c16569.
Article
PubMed
Google Scholar
Lee J, Liao H, Wang Q, Han J, Han J-H, Shin HE, Ge M, Park W, Li F. Exploration of nanozymes in viral diagnosis and therapy. Exploration. 2022;2:20210086. https://doi.org/10.1002/exp.20210086.
Article
PubMed
PubMed Central
Google Scholar
Liang X, Liu T, Li L, Li J, Li S, Zeng K, et al. Translational selenium nanotherapeutics counter-acts multiple risk factors to improve surgery-induced cognitive impairment. Chem Eng J. 2022;441:135984. https://doi.org/10.1016/j.cej.2022.135984.
Article
Google Scholar
Shahraki S, Vaziri E, Saboury AA, Fan K. Biomedical potential of nanozymes: harnessing redox enzyme mimicry for theranostic applications. Coord Chem Rev. 2024;517:215937. https://doi.org/10.1016/j.ccr.2024.215937.
Article
Google Scholar
Birhan YS, Tsai HC. Recent developments in selenium-containing polymeric micelles: prospective stimuli, drug-release behaviors, and intrinsic anticancer activity. J Mater Chem B. 2021;9:6770–801. https://doi.org/10.1039/d1tb01253c.
Article
PubMed
Google Scholar
Huang Y, Su E, Ren J, Qu X. The recent biological applications of selenium-based nanomaterials. Nano Today. 2021;38:101205. https://doi.org/10.1016/j.nantod.2021.101205.
Article
Google Scholar
Song X, Chen Y, Zhao G, Sun H, Che H, Leng X. Effect of molecular weight of chitosan and its oligosaccharides on antitumor activities of chitosan-selenium nanoparticles. Carbohydr Polym. 2020;231:115689. https://doi.org/10.1016/j.carbpol.2019.115689.
Article
PubMed
Google Scholar
Zhai X, Zhang C, Zhao G, Stoll S, Ren F, Leng X. Antioxidant capacities of the selenium nanoparticles stabilized by chitosan. J Nanobiotechnol. 2017;15:4. https://doi.org/10.1186/s12951-016-0243-4.
Article
Google Scholar
Bai K, Hong B, Hong Z, Sun J, Wang C. Selenium nanoparticles-loaded chitosan/citrate complex and its protection against oxidative stress in d-galactose-induced aging mice. J Nanobiotechnol. 2017;15:92. https://doi.org/10.1186/s12951-017-0324-z.
Article
Google Scholar
Hamed AA, Hawwa MT, Baraka DM, El-Shora HM, El-Sayyad GS, Al-Hazmi NE, et al. Understanding antimicrobial activity of biogenic selenium nanoparticles and selenium/chitosan nano-incorporates via studying their inhibition activity against key metabolic enzymes. Int J Biol Macromol. 2025;298:140073. https://doi.org/10.1016/j.ijbiomac.2025.140073.
Article
PubMed
Google Scholar
Sun R, Li S, Chen Z, Zheng K, Li W, Sun X, Yue W. Oral antioxidant-engineered probiotics for the treatment of radiation-induced colitis. ACS Appl Mater Interfaces. 2025;17:10316–27. https://doi.org/10.1021/acsami.4c17651.
Article
PubMed
Google Scholar
Tan L, Jia X, Jiang X, Zhang Y, Tang H, Yao S, et al. In vitro study on the individual and synergistic cytotoxicity of adriamycin and selenium nanoparticles against Bel7402 cells with a quartz crystal microbalance. Biosens Bioelectron. 2009;24:2268–72. https://doi.org/10.1016/j.bios.2008.10.030.
Article
PubMed
Google Scholar
Su X, Liu W, Yang B, Yang S, Hou J, Yu G, et al. Constructing network structures to enhance stability and target deposition of selenium nanoparticles via amphiphilic sodium alginate and alkyl glycosides. Int J Biol Macromol. 2024;267:131588. https://doi.org/10.1016/j.ijbiomac.2024.131588.
Article
PubMed
Google Scholar
Naveenkumar S, Venkateshan N, Kaviyarasu K, Christyraj JRSS, Muthukumaran A. Optimum performance of a novel biocompatible scaffold comprising alginate-pectin-selenium nanoparticles for cardiac tissue engineering using C2C12 cells. J Mol Struct. 2023;1294:136457. https://doi.org/10.1016/j.molstruc.2023.136457.
Article
Google Scholar
Li X-N, Lin L, Li X-W, Zhu Q, Xie Z-Y, Hu Y-Z, et al. BSA-stabilized selenium nanoparticles ameliorate intracerebral hemorrhage’s-like pathology by inhibiting ferroptosis-mediated neurotoxicology via Nrf2/GPX4 axis activation. Redox Biol. 2024;75:103268. https://doi.org/10.1016/j.redox.2024.103268.
Article
PubMed
PubMed Central
Google Scholar
Xu K, Huang P, Wu Y, Liu T, Shao N, Zhao L, et al. Engineered selenium/human serum albumin nanoparticles for efficient targeted treatment of Parkinson’s disease via oral gavage. ACS Nano. 2023;17:19961–80. https://doi.org/10.1021/acsnano.3c05011.
Article
PubMed
PubMed Central
Google Scholar
Wang S, Chen Y, Han S, Liu Y, Gao J, Huang Y, Sun W, Wang J, Wang C, Zhao J. Selenium nanoparticles alleviate ischemia reperfusion injury-induced acute kidney injury by modulating GPx-1/NLRP3/Caspase-1 pathway. Theranostics. 2022;12:3882–95. https://doi.org/10.7150/thno.70830.
Article
PubMed
PubMed Central
Google Scholar
Ferro C, Matos AI, Serpico L, Fontana F, Chiaro J, D’Amico C, Correia A, Koivula R, Kemell M, Gaspar MM, et al. Selenium nanoparticles synergize with a Kras nanovaccine against breast cancer. Adv Healthc Mater. 2025;14:2401523. https://doi.org/10.1002/adhm.202401523.
Article
PubMed
Google Scholar
Ruiz-Fresneda MA, Schaefer S, Hübner R, Fahmy K, Merroun ML. Exploring antibacterial activity and bacterial-mediated allotropic transition of differentially coated selenium nanoparticles. ACS Appl Mater Interfaces. 2023;15:29958–70. https://doi.org/10.1021/acsami.3c05100.
Article
PubMed
PubMed Central
Google Scholar
Bu Q, Jiang D, Yu Y, Deng Y, Chen T, Xu L. Surface chemistry engineered selenium nanoparticles as bactericidal and immuno-modulating dual-functional agents for combating methicillin-resistant Staphylococcus aureus infection. Drug Resist Updat. 2024;76:101102. https://doi.org/10.1016/j.drup.2024.101102.
Article
PubMed
Google Scholar
Tarrahi R, Khataee A, Movafeghi A, Rezanejad F, Gohari G. Toxicological implications of selenium nanoparticles with different coatings along with Se4 + on Lemna minor. Chemosphere. 2017;181:655–65. https://doi.org/10.1016/j.chemosphere.2017.04.142.
Article
PubMed
Google Scholar
Zhang C, Zhai X, Zhao G, Ren F, Leng X. Synthesis, characterization, and controlled release of selenium nanoparticles stabilized by chitosan of different molecular weights. Carbohydr Polym. 2015;134:158–66. https://doi.org/10.1016/j.carbpol.2015.07.065.
Article
PubMed
Google Scholar
Krishnaraj C, Radhakrishnan S, Ramachandran R, Ramesh T, Kim B-S, Yun S-I. In vitro toxicological assessment and biosensing potential of bioinspired chitosan nanoparticles, selenium nanoparticles, chitosan/selenium nanocomposites, silver nanoparticles and chitosan/silver nanocomposites. Chemosphere. 2022;301:134790. https://doi.org/10.1016/j.chemosphere.2022.134790.
Article
PubMed
Google Scholar
Chen W, Li Y, Yang S, Yue L, Jiang Q, Xia W. Synthesis and antioxidant properties of chitosan and carboxymethyl chitosan-stabilized selenium nanoparticles. Carbohydr Polym. 2015;132:574–81. https://doi.org/10.1016/j.carbpol.2015.06.064.
Article
PubMed
Google Scholar
Luo Y, Zhang B, Cheng W-H, Wang Q. Preparation, characterization and evaluation of selenite-loaded chitosan/TPP nanoparticles with or without zein coating. Carbohydr Polym. 2010;82:942–51. https://doi.org/10.1016/j.carbpol.2010.06.029.
Article
Google Scholar
Wu Y, Xu W, Jiao L, Tang Y, Chen Y, Gu W, Zhu C. Defect engineering in nanozymes. Mater Today. 2022;52:327–47. https://doi.org/10.1016/j.mattod.2021.10.032.
Article
Google Scholar
Wang R, Zhang T, Zhang W, Chen B, Liu J, Liu G, et al. Microperoxidase-11 functionalized nanozyme with enhanced peroxidase-mimicking activities for visual detection of cysteine. Anal Chim Acta. 2023;1267:341386. https://doi.org/10.1016/j.aca.2023.341386.
Article
PubMed
Google Scholar
Hühn D, Kantner K, Geidel C, Brandholt S, De Cock I, Soenen SJH, et al. Polymer-coated nanoparticles interacting with proteins and cells: focusing on the sign of the net charge. ACS Nano. 2013;7:3253–63. https://doi.org/10.1021/nn3059295.
Khan MD, Malik MA, Revaprasadu N. Progress in selenium based metal-organic precursors for main group and transition metal selenide thin films and nanomaterials. Coord Chem Rev. 2019;388:24–47. https://doi.org/10.1016/j.ccr.2019.02.026.
Article
Google Scholar
Qian F, Peng L, Cao D, Jiang W, Hu C, Huang J, et al. Asymmetric active sites originate from high-entropy metal selenides by joule heating to boost electrocatalytic water oxidation. Joule. 2024;8:2342–56. https://doi.org/10.1016/j.joule.2024.06.004.
Article
Google Scholar
Li Y, Yu J, Zhang W, Shan J, Chen H, Ma Y, et al. Copper selenide nanosheets with photothermal therapy-related properties and multienzyme activity for highly effective eradication of drug resistance. J Colloid Interface Sci. 2024;666:434–46. https://doi.org/10.1016/j.jcis.2024.03.176.
Article
PubMed
Google Scholar
Chalana A, Karri R, Das R, Kumar B, Rai RK, Saxena H, et al. Copper-driven deselenization: a strategy for selective conversion of copper ion to nanozyme and its implication for copper-related disorders. ACS Appl Mater Interfaces. 2019;11:4766–76. https://doi.org/10.1021/acsami.8b16786.
Article
PubMed
Google Scholar
Feng Y, Liu Z, Feng Y, Wang J, Chen J, Dong Z, et al. A pH-responsive copper selenide nanozyme modulates multiple enzyme activities for improved healing of infected wounds. Appl Mater Today. 2024;41:102518. https://doi.org/10.1016/j.apmt.2024.102518.
Article
Google Scholar
Tian R, Ma H, Ye W, Li Y, Wang S, Zhang Z, et al. Se-containing Mof coated dual-fe-atom nanozymes with multi-enzyme cascade activities protect against cerebral ischemic reperfusion injury. Adv Funct Mater. 2022;32:2204025. https://doi.org/10.1002/adfm.202204025.
Article
Google Scholar
Zhu D, Wu H, Jiang K, Xu Y, Miao Z, Wang H, et al. Zero-valence selenium-enriched Prussian blue nanozymes reconstruct intestinal barrier against inflammatory bowel disease via inhibiting ferroptosis and T cells differentiation. Adv Healthc Mater. 2023;12:2203160. https://doi.org/10.1002/adhm.202203160.
Article
Google Scholar
Li Y, Cao Y, Ma K, Ma R, Zhang M, Guo Y, et al. A triple-responsive polymeric prodrug nanoplatform with extracellular ROS consumption and intracellular H2O2 self-generation for imaging-guided tumor chemo-ferroptosis-immunotherapy. Adv Healthc Mater. 2024;13:2303568. https://doi.org/10.1002/adhm.202303568.
Article
Google Scholar
Chen L, Ding C, Chai K, Yang B, Chen W, Zeng J, et al. Nanohole-array induced metallic molybdenum selenide nanozyme for photoenhanced tumor-specific therapy. ACS Nano. 2023;17:18148–63. https://doi.org/10.1021/acsnano.3c05000.
Article
PubMed
Google Scholar
Meng R-Y, Zhao Y, Xia H-Y, Wang S-B, Chen A-Z, Kankala RK. 2D architectures-transformed conformational nanoarchitectonics for light-augmented nanocatalytic chemodynamic and photothermal/photodynamic-based trimodal therapies. ACS Mater Lett. 2024;6:1160–77. https://doi.org/10.1021/acsmaterialslett.3c01615.
Article
Google Scholar
Zhang J, Ye W, Wan L, Shi N, Peng C, Shi Y, et al. Beating xenograft liposarcoma using metal selenides with NIR-III photothermal ablation and bioactive selenium derivates. Chem Eng J. 2024;481:148521. https://doi.org/10.1016/j.cej.2024.148521.
Article
Google Scholar
Xiao J, Zhang G, Xu R, Chen H, Wang H, Tian G, Wang B, Yang C, Bai G, Zhang Z, et al. A pH-responsive platform combining chemodynamic therapy with limotherapy for simultaneous bioimaging and synergistic cancer therapy. Biomaterials. 2019;216:119254. https://doi.org/10.1016/j.biomaterials.2019.119254.
Article
PubMed
Google Scholar
Pei M, Liu K, Qu X, Wang K, Chen Q, Zhang Y, Wang X, Wang Z, Li X, Chen F, et al. Enzyme-catalyzed synthesis of selenium-doped manganese phosphate for synergistic therapy of drug-resistant colorectal cancer. J Nanobiotechnol. 2023;21:72. https://doi.org/10.1186/s12951-023-01819-0.
Article
Google Scholar
Han Y, Yi H, Wang Y, Li Z, Chu X, Jiang J-H. Ultrathin zinc selenide nanoplatelets boosting photoacoustic imaging of in situ copper exchange in Alzheimer’s disease mice. ACS Nano. 2022;16:19053–66. https://doi.org/10.1021/acsnano.2c08094.
Article
PubMed
Google Scholar
Gao M, Wang Z, Zheng H, Wang L, Xu S, Liu X, et al. Two-dimensional Tin Selenide (snse) nanosheets capable of mimicking key dehydrogenases in cellular metabolism. Angew Chem Int Ed. 2020;59:3618–23. https://doi.org/10.1002/anie.201913035.
Article
Google Scholar
Wu D, Li J, Xu S, Xie Q, Pan Y, Liu X, et al. Engineering Fe–N doped graphene to mimic biological functions of NADPH oxidase in cells. J Am Chem Soc. 2020;142:19602–10. https://doi.org/10.1021/jacs.0c08360.
Article
PubMed
Google Scholar
Wu G, Wei P, Chen X, Zhang Z, Jin Z, Liu J, et al. Less is more: biological effects of NiSe2/rGO nanocomposites with low dose provide new insight for risk assessment. J Hazard Mater. 2021;415:125605. https://doi.org/10.1016/j.jhazmat.2021.125605.
Article
PubMed
Google Scholar
Derfus AM, Chan WCW, Bhatia SN. Probing the cytotoxicity of semiconductor quantum dots. Nano Lett. 2004;4:11–8. https://doi.org/10.1021/nl0347334.
Article
PubMed
Google Scholar
Shi Y, Li Y, Huang C, Xu Y, Xu Y. Electrogenerated copper selenide with positive charge to efficiently capture and combat drug-resistant bacteria for wound healing. J Colloid Interface Sci. 2023;634:852–63. https://doi.org/10.1016/j.jcis.2022.12.094.
Article
PubMed
Google Scholar
Sun H, Miao L, Li J, Fu S, An G, Si C, Dong Z, Luo Q, Yu S, Xu J, Liu J. Self-assembly of cricoid proteins induced by soft nanoparticles: an approach to design multienzyme-cooperative antioxidative systems. ACS Nano. 2015;9:5461–9. https://doi.org/10.1021/acsnano.5b01311.
Article
PubMed
Google Scholar
Xia D, Yu H, Li H, Huang P, Li Q, Wang Y. Carbon-based and carbon-supported nanomaterials for the catalytic conversion of biomass: a review. Environ Chem Lett. 2022;20:1719–44. https://doi.org/10.1007/s10311-022-01402-3.
Article
Google Scholar
Sun B, Luo C, Zhang X, Guo M, Sun M, Yu H, Chen Q, Yang W, Wang M, Zuo S, et al. Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy. Nat Commun. 2019;10:3211. https://doi.org/10.1038/s41467-019-11193-x.
Article
PubMed
PubMed Central
Google Scholar
Xiao X, Shao Z, Yu L. A perspective of the engineering applications of carbon-based selenium-containing materials. Chin Chem Lett. 2021;32:2933–8. https://doi.org/10.1016/j.cclet.2021.03.047.
Article
Google Scholar
Gao F, Liu J, Gong P, Yang Y, Jiang Y. Carbon dots as potential antioxidants for the scavenging of multi-reactive oxygen and nitrogen species. Chem Eng J. 2023;462:142338. https://doi.org/10.1016/j.cej.2023.142338.
Article
Google Scholar
Huang H, Shen Z, Chen B, Wang X, Xia Q, Ge Z, Wang Y, Li X. Selenium-doped two-photon fluorescent carbon nanodots for in-situ free radical scavenging in mitochondria. J Colloid Interface Sci. 2020;567:402–9. https://doi.org/10.1016/j.jcis.2020.02.011.
Article
PubMed
Google Scholar
Li F, Li T, Sun C, Xia J, Jiao Y, Xu H. Selenium-doped carbon quantum dots for free-radical scavenging. Angew Chem. 2017. https://doi.org/10.1002/ange.201705989.
Article
Google Scholar
Nam NTH, Truong DP, An TTV, Huong QTT, Tuyen NNK, An H, et al. Biological activity prospects of selenium-decorated graphene oxide composite by green synthesis using Sesbania sesban flower extract. Diamond Relat Mater. 2024;141:110563. https://doi.org/10.1016/j.diamond.2023.110563.
Article
Google Scholar
Xia J, Li F, Ji S, Xu H. Selenium-functionalized graphene oxide that can modulate the balance of reactive oxygen species. ACS Appl Mater Interfaces. 2017;9:21413–21. https://doi.org/10.1021/acsami.7b05951.
Article
PubMed
Google Scholar
Sun J, Yan M, Tao G, Su R, Xiao X, Wu Q, et al. A single-atom manganese nanozyme mediated membrane reactor for water decontamination. Water Res. 2025;268:122627. https://doi.org/10.1016/j.watres.2024.122627.
Article
PubMed
Google Scholar
Lu Y, Zhang X, Huang Y. Dual-site Se/NC specific peroxidase-like nanozyme for highly sensitive methimazole detection. Chin Chem Lett. 2025;36:110129. https://doi.org/10.1016/j.cclet.2024.110129.
Article
Google Scholar
Jiang Z, Li H, Ai R, Deng Y, He Y. Electrostatic-driven coordination interaction enables high specificity of UO22 + peroxidase mimic for visual colorimetric detection of UO22+. ACS Sustain Chem Eng. 2020;8:11630–7. https://doi.org/10.1021/acssuschemeng.0c02995.
Article
Google Scholar
Wang Z, Li G, Gao Y, Yu Y, Yang P, Li B, et al. Trienzyme-like iron phosphates-based (FePOs) nanozyme for enhanced anti-tumor efficiency with minimal side effects. Chem Eng J. 2021;404:125574. https://doi.org/10.1016/j.cej.2020.125574.
Article
Google Scholar
Chen J, Liu X, Zheng G, Feng W, Wang P, Gao J, Liu J, Wang M, Wang Q. Detection of glucose based on noble metal nanozymes: mechanism, activity regulation, and enantioselective recognition. Small. 2023;19:2205924. https://doi.org/10.1002/smll.202205924.
Article
Google Scholar
Lian X, Huang Y, Zhu Y, Fang Y, Zhao R, Joseph E, et al. Enzyme-MOF nanoreactor activates nontoxic paracetamol for cancer therapy. Angew Chem Int Ed. 2018;57(20):5725–30. https://doi.org/10.1002/anie.201801378.
Article
Google Scholar
Sun H, Zhou Y, Ren J, Qu X. Carbon nanozymes: enzymatic properties, catalytic mechanism, and applications. Angew Chem Int Ed. 2018;57:9224–37. https://doi.org/10.1002/anie.201712469.
Article
Google Scholar
Kang L, Wu Y, Jia Y, Chen Z, Kang D, Zhang L, et al. Nano-selenium enhances melon resistance to podosphaera xanthii by enhancing the antioxidant capacity and promoting alterations in the polyamine, phenylpropanoid and hormone signaling pathways. J Nanobiotechnol. 2023;21:377. https://doi.org/10.1186/s12951-023-02148-y.
Article
Google Scholar
Li R, Kong W, An Z. Enzyme catalysis for reversible deactivation radical polymerization. Angew Chem Int Ed. 2022;61:e202202033. https://doi.org/10.1002/anie.202202033.
Article
Google Scholar
Huanhuan N, Xiaoxiao L, Guojuan Y, Chengzhi H, Hongyan Z. Colorimetric evaluation of total antioxidant capacity based on peroxidase-like nonstoichiometric Cu2-xSe nanoparticles. Sens Actuators B. 2023. https://doi.org/10.1016/j.snb.2023.134794.
Article
Google Scholar
Tarrahi R, Movafeghi A, Khataee A, Rezanejad F, Gohari G. Evaluating the toxic impacts of cadmium selenide nanoparticles on the aquatic plant lemna minor. Molecules. 2019;24:410. https://doi.org/10.3390/molecules24030410.
Article
PubMed
PubMed Central
Google Scholar
Chen C, Wang Y, Zhang D. Oxygen vacancy tuned oxidase mimic through selenium-doping ultrathin 2D Ni-V mixed metal oxide and antibacterial application. J Alloys Compd. 2022;915:165446. https://doi.org/10.1016/j.jallcom.2022.165446.
Article
Google Scholar
Ingold I, Berndt C, Schmitt S, Doll S, Poschmann G, Buday K, Roveri A, Peng X, Porto Freitas F, Seibt T, et al. Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis. Cell. 2018;172:409–e422421. https://doi.org/10.1016/j.cell.2017.11.048.
Article
PubMed
Google Scholar
Zhang D, Shen N, Zhang J, Zhu J, Guo Y, Xu L. A novel nanozyme based on selenopeptide-modified gold nanoparticles with a tunable glutathione peroxidase activity. RSC Adv. 2020;10:8685–91. https://doi.org/10.1039/c9ra10262k.
Article
PubMed
PubMed Central
Google Scholar
Wang W, Zheng J, Zhou H, Liu Q, Jia L, Zhang X, et al. Polydopamine-based nanocomposite as a biomimetic antioxidant with a variety of enzymatic activities for Parkinson’s disease. ACS Appl Mater Interfaces. 2022;14:32901–13. https://doi.org/10.1021/acsami.2c06981.
Article
PubMed
Google Scholar
Ringuet MT, Hunne B, Lenz M, Bravo DM, Furness JB. Analysis of bioavailability and induction of glutathione peroxidase by dietary nanoelemental, organic and inorganic selenium. Nutrients. 2021;13:1073. https://doi.org/10.3390/nu13041073.
Article
PubMed
PubMed Central
Google Scholar
Zhai Q, Cen S, Li P, Tian F, Zhao J, Zhang H, Chen W. Effects of dietary selenium supplementation on intestinal barrier and immune responses associated with its modulation of gut microbiota. Environ Sci Technol Lett. 2018;5:724–30. https://doi.org/10.1021/acs.estlett.8b00563.
Article
Google Scholar
Zhang Z, Yan A, Xu Z, Tian R, Hou C, Luo Q, et al. Engineering biomimetic ATP-responsive Se-containing core-shell cascade nanozyme for efficient tumor combination therapy. Chem Eng J. 2023;454:140165. https://doi.org/10.1016/j.cej.2022.140165.
Article
Google Scholar
Xu K, Huang P, Peng Y, Qu S. Reply to comment on ‘engineered selenium/human serum albumin nanoparticles for efficient targeted treatment of parkinson’s disease via oral gavage. ACS Nano. 2024;18:11489–91. https://doi.org/10.1021/acsnano.4c04245.
Article
PubMed
Google Scholar
Yang H, Wang Z, Li L, Wang X, Wei X, Gou S, Ding Z, Cai Z, Ling Q, Hoffmann PR, et al. Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression. J Nanobiotechnol. 2024;22:613. https://doi.org/10.1186/s12951-024-02861-2.
Article
Google Scholar
Zhou C, Zhao Y, Yang M, Yin W, Li Y, Xiao Y, et al. Diselenide-containing polymer based on new antitumor mechanism as efficient Gsh depletion agent for ferroptosis therapy. Adv Healthc Mater. 2024;13:2303896. https://doi.org/10.1002/adhm.202303896.
Article
Google Scholar
Lai H, Zhang X, Song Z, Yuan Z, He L, Chen T. Facile synthesis of antioxidative nanotherapeutics using a microwave for efficient reversal of cisplatin-induced nephrotoxicity. Chem Eng J. 2020;391:123563. https://doi.org/10.1016/j.cej.2019.123563.
Article
Google Scholar
Singh N, NaveenKumar SK, Geethika M, Mugesh G. A cerium vanadate nanozyme with specific superoxide dismutase activity regulates mitochondrial function and ATP synthesis in neuronal cells. Angew Chem Int Ed. 2021;60:3121–30. https://doi.org/10.1002/anie.202011711.
Article
Google Scholar
Deng Z, Ma W, Ding C, Wei C, Gao B, Zhu Y, Zhang Y, Wu F, Zhang M, Li R, Zhang M. Metal polyphenol network/cerium oxide artificial enzymes therapeutic nanoplatform for MRI/CT-aided intestinal inflammation management. Nano Today. 2023;53:102044. https://doi.org/10.1016/j.nantod.2023.102044.
Article
Google Scholar
Gong Y, Huang J, Xing X, Liu H, Zhou Z, Dong H. Red emissive carbon dots self-cascading antioxidant nanozymes combine with anti-miRNA-155 for accurate monitoring and ameliorating rheumatoid arthritis. Chem Eng J. 2024;481:148523. https://doi.org/10.1016/j.cej.2024.148523.
Article
Google Scholar
Shang L, Yu Y, Jiang Y, Liu X, Sui N, Yang D, Zhu Z. Ultrasound-augmented multienzyme-like nanozyme hydrogel spray for promoting diabetic wound healing. ACS Nano. 2023;17:15962–77. https://doi.org/10.1021/acsnano.3c04134.
Article
PubMed
Google Scholar
Liu K, Niu J, Liu L, Tian F, Nie H, Liu X, et al. LUMO-mediated se and HOMO-mediated te nanozymes for selective redox biocatalysis. Nano Lett. 2023;23:5131–40. https://doi.org/10.1021/acs.nanolett.3c01068.
Article
PubMed
Google Scholar
Dong K, Xu C, Ren J, Qu X. Chiral nanozymes for enantioselective biological catalysis. Angew Chem Int Ed. 2022;61:e202208757. https://doi.org/10.1002/anie.202208757.
Article
Google Scholar
Zhang X, An Z, An J, Tian X. Bioinspired chiral nanozymes: synthesis strategies, classification, biological effects and biomedical applications. Coord Chem Rev. 2024;502:215601. https://doi.org/10.1016/j.ccr.2023.215601.
Article
Google Scholar
Liu X, Zhang H, Hao C, Kuang H, Xu C, Xu L. Chiral Se@CeO2 superparticles for ameliorating parkinson’s disease. Nanoscale. 2023;15:4367–77. https://doi.org/10.1039/d2nr04534f.
Article
PubMed
Google Scholar
Wang W, Zhang Z, Liu Y, Kong L, Li W, Hu W, et al. Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury. Biomater Sci. 2022;10:7103–16. https://doi.org/10.1039/d2bm01401g.
Article
PubMed
Google Scholar
Zhao S, Li Y, Liu Q, Li S, Cheng Y, Cheng C, et al. An orally administered CeO2@montmorillonite nanozyme targets inflammation for inflammatory bowel disease therapy. Adv Funct Mater. 2020;30:2004692. https://doi.org/10.1002/adfm.202004692.
Article
Google Scholar
Zhang W, Hu S, Yin J-J, He W, Lu W, Ma M, Gu N, Zhang Y. Prussian blue nanoparticles as multienzyme mimetics and reactive oxygen species scavengers. J Am Chem Soc. 2016;138:5860–5. https://doi.org/10.1021/jacs.5b12070.
Article
PubMed
Google Scholar
Singh N, Savanur MA, Srivastava S, D’Silva P, Mugesh G. A redox modulatory Mn3O4 nanozyme with multi-enzyme activity provides efficient cytoprotection to human cells in a parkinson’s disease model. Angew Chem Int Ed. 2017;56:14267–71. https://doi.org/10.1002/anie.201708573.
Article
Google Scholar
Yan X, Meng L, Zhang X, Deng Z, Gao B, Zhang Y, et al. Reactive oxygen species-responsive nanocarrier ameliorates murine colitis by intervening colonic innate and adaptive immune responses. Mol Ther. 2023;31:1383–401. https://doi.org/10.1016/j.ymthe.2023.02.017.
Article
PubMed
PubMed Central
Google Scholar
Somerville SV, Li Q, Wordsworth J, Jamali S, Eskandarian MR, Tilley RD, et al. Approaches to improving the selectivity of nanozymes. Adv Mater. 2023;2211288. https://doi.org/10.1002/adma.202211288.
Article
Google Scholar
Li L, Lu Y, Xu X, Yang X, Chen L, Jiang C, et al. Catalytic-enhanced lactoferrin-functionalized Au-Bi2Se3 nanodots for parkinson’s disease therapy via reactive oxygen attenuation and mitochondrial protection. Adv Healthc Mater. 2021;10:2100316. https://doi.org/10.1002/adhm.202100316.
Article
Google Scholar
Xiong Z, He L, Pi F, Yu Y, Xiao Z, Chen T. Intracellular redox environment determines cancer-normal cell selectivity of selenium nanoclusters. Angew Chem Int Ed. 2025;64:e202416006. https://doi.org/10.1002/anie.202416006.
Article
Google Scholar
Duo Y, Luo G, Li Z, Chen Z, Li X, Jiang Z, et al. Photothermal and enhanced photocatalytic therapies conduce to synergistic anticancer phototherapy with biodegradable titanium diselenide nanosheets. Small. 2021;17:2103239. https://doi.org/10.1002/smll.202103239.
Article
Google Scholar
You Y, Chang Y, Pan S, Bu Q, Ling J, He W, et al. Cleavage of homonuclear chalcogen-chalcogen bonds in a hybrid platform in response to x-ray radiation potentiates tumor radiochemotherapy. Angew Chem Int Ed. 2025;64:e202412922. https://doi.org/10.1002/anie.202412922.
Article
Google Scholar
Peng S-Y, Liu X-H, Chen Q-W, Yu Y-J, Liu M-D, Zhang X-Z. Harnessing in situ glutathione for effective ROS generation and tumor suppression via nanohybrid-mediated catabolism dynamic therapy. Biomaterials. 2022;281:121358. https://doi.org/10.1016/j.biomaterials.2021.121358.
Article
PubMed
Google Scholar
Sun C, Zhang X, Huang H, Liu Y, Mo X, Feng Y, et al. Selective oxidation of p-phenylenediamine for blood glucose detection enabled by Se-vacancy-rich TiSe2-x@Au nanozyme. Biosens Bioelectron. 2023;241:115665. https://doi.org/10.1016/j.bios.2023.115665.
Article
PubMed
Google Scholar
Jin K, Shi S, Huang D, Huang H, Zou B, Huang W, et al. Maintaining cardiac homeostasis by translational selenium nanoparticles with rapid selenoproteins regulation to achieve radiation-induced heart prevention. Chem Eng J. 2025;506:160005. https://doi.org/10.1016/j.cej.2025.160005.
Article
Google Scholar
Xu K, Zhu Y, Qian J, He Y, Liu Y, Lu B, et al. Trigger selenium sites and stable multiphasic-engineered modulated BiFeO3/MoSe2-1T/2H photocatalyst for hydrogen peroxide production. Appl Catal B. 2024;343:123571. https://doi.org/10.1016/j.apcatb.2023.123571.
Article
Google Scholar
Wang J, Liu X, Liao T, Ma C, Chen B, Li Y, et al. Fe doping induced selenium vacancy on Cobalt Selenide for enhanced hydrogen peroxides production. Appl Catal B. 2024;341:123344. https://doi.org/10.1016/j.apcatb.2023.123344.
Article
Google Scholar
Rotruck JT, Pope AL, Ganther HE, Swanson AB, Hafeman DG, Hoekstra WG. Selenium: biochemical role as a component of glutathione peroxidase. Science. 1973;179:588–90. https://doi.org/10.1126/science.179.4073.588.
Article
PubMed
Google Scholar
Zade SS, Singh HB, Butcher RJ. The isolation and crystal structure of a cyclic selenenate ester derived from bis(2,6-diformyl-4-tert-butylphenyl)diselenide and its glutathione peroxidase-like activity. Angew Chem Int Ed. 2004;43:4513–5. https://doi.org/10.1002/anie.200460380.
Article
Google Scholar
Ungati H, Govindaraj V, Narayanan M, Mugesh G. Probing the formation of a seleninic acid in living cells by the fluorescence switching of a glutathione peroxidase mimetic. Angew Chem Int Ed. 2019;58:8156–60. https://doi.org/10.1002/anie.201903958.
Article
Google Scholar
Zhao R, Zhu Y, Zhou J, Liu B, Du Y, Gai S, et al. Dual glutathione depletion enhanced enzyme catalytic activity for hyperthermia assisted tumor therapy on semi-metallic VSe2/Mn-CS. ACS Nano. 2022;16:10904–17. https://doi.org/10.1021/acsnano.2c03222.
Article
PubMed
Google Scholar
Nathan C. Resisting antimicrobial resistance. Nat Rev Microbiol. 2020;18:259–60. https://doi.org/10.1038/s41579-020-0348-5.
Article
PubMed
Google Scholar
Mei L, Zhu S, Liu Y, Yin W, Gu Z, Zhao Y. An overview of the use of nanozymes in antibacterial applications. Chem Eng J. 2021;418:129431. https://doi.org/10.1016/j.cej.2021.129431.
Article
Google Scholar
Hou J, Fu R, Yu T, Ge P, Wang Y, Zhao M, Zou A, Xianyu Y. Synergistic antibacterial therapy for multidrug-resistant bacterial infections using multifunctional nanozymes. Nano Today. 2024;54:102118. https://doi.org/10.1016/j.nantod.2023.102118.
Article
Google Scholar
Mao L, Wang L, Zhang M, Ullah MW, Liu L, Zhao W, et al. In situ synthesized selenium nanoparticles-decorated bacterial cellulose/gelatin hydrogel with enhanced antibacterial, antioxidant, and anti-inflammatory capabilities for facilitating skin wound healing. Adv Healthc Mater. 2021;10:2100402. https://doi.org/10.1002/adhm.202100402.
Article
Google Scholar
He D, Liu X, Jia J, Peng B, Xu N, Zhang Q, et al. Magnetic field-directed deep thermal therapy via double-layered microneedle patch for promoting tissue regeneration in infected diabetic skin wounds. Adv Funct Mater. 2024;34:2306357. https://doi.org/10.1002/adfm.202306357.
Article
Google Scholar
Lian Y, Wang Y, Zhang D, Xu L. Peroxidase-like and oxidase-like nanozyme activities of reusable Mn-Co-S-Se/Ni foam for antibacterial application. Colloids Surf A Physicochem Eng Asp. 2021;626:127010. https://doi.org/10.1016/j.colsurfa.2021.127010.
Article
Google Scholar
Mu X-P, Li T, Guo F-F, Xu Z-H, Sun P, Zhang X, et al. Se nanoparticles-loaded and Mo-doped iron phthalocyanine nanorods as photoresponsive nanozyme for efficient synergistic sterilization. Mater Lett. 2023;346:134565. https://doi.org/10.1016/j.matlet.2023.134565.
Article
Google Scholar
Tu Z, Zhong Y, Hu H, Shao D, Haag R, Schirner M, et al. Design of therapeutic biomaterials to control inflammation. Nat Rev Mater. 2022;7:557–74. https://doi.org/10.1038/s41578-022-00426-z.
Article
PubMed
PubMed Central
Google Scholar
Parthasarathi S, Muthukumar SP, Anandharamakrishnan C. The influence of droplet size on the stability, in vivo digestion, and oral bioavailability of vitamin E emulsions. Food Funct. 2016;7:2294–302. https://doi.org/10.1039/c5fo01517k.
Article
PubMed
Google Scholar
LaForge JM, Urso K, Day JM, Bourgeois CW, Ross MM, Ahmadzadeh S, et al. Non-steroidal anti-inflammatory drugs: clinical implications, renal impairment risks, and AKI. Adv Ther. 2023;40:2082–96. https://doi.org/10.1007/s12325-023-02481-6.
Article
PubMed
Google Scholar
Woodle ES, Gill JS, Clark S, Stewart D, Alloway R, First R. Early corticosteroid cessation vs long-term corticosteroid therapy in kidney transplant recipients: long-term outcomes of a randomized clinical trial. JAMA Surg. 2021;156:307–14. https://doi.org/10.1001/jamasurg.2020.6929.
Article
PubMed
PubMed Central
Google Scholar
Huang Y, Liu Z, Liu C, Zhang Y, Ren J, Qu X. Selenium-based nanozyme as biomimetic antioxidant machinery. Chem-Eur J. 2018;24:10224–30. https://doi.org/10.1002/chem.201801725.
Article
PubMed
Google Scholar
Chen X, Zhu X, Gong Y, Yuan G, Cen J, Lie Q, et al. Porous selenium nanozymes targeted scavenging ROS synchronize therapy local inflammation and sepsis injury. Appl Mater Today. 2021;22:100929. https://doi.org/10.1016/j.apmt.2020.100929.
Article
Google Scholar
Chen X, Yang Y, Mai Q, Ye G, Liu Y, Liu J. Pillar arene se nanozyme therapeutic systems with dual drive power effectively penetrated mucus layer combined therapy acute lung injury. Biomaterials. 2024;304:122384. https://doi.org/10.1016/j.biomaterials.2023.122384.
Article
PubMed
Google Scholar
Ai Y, You J, Gao J, Wang J, Sun H-b, Ding M, Liang Q. Multi-shell nanocomposites based multienzyme mimetics for efficient intracellular antioxidation. Nano Res. 2021;14:2644–53. https://doi.org/10.1007/s12274-020-3267-x.
Article
Google Scholar
Huang X, Zhou Y, Guo Y, Yan D, Sun P, Cao Y, Chen Y, Peng J. Selenium-doped copper formate nanozymes with antisenescence and oxidative stress reduction for atherosclerosis treatment. Nano Lett. 2025;25:2662–9. https://doi.org/10.1021/acs.nanolett.4c05348.
Article
PubMed
Google Scholar
Deng Y, Gao Y, Li T, Xiao S, Adeli M, Rodriguez RD, Geng W, Chen Q, Cheng C, Zhao C. Amorphizing metal selenides-based ROS biocatalysts at surface nanolayer toward ultrafast inflammatory diabetic wound healing. ACS Nano. 2023;17:2943–57. https://doi.org/10.1021/acsnano.2c11448.
Article
PubMed
Google Scholar
Fu Y, Wang T, Ge X, Wen H, Fei Y, Li M, et al. Orally-deliverable liposome-microgel complexes dynamically remodel intestinal environment to enhance probiotic ulcerative colitis therapy via TLR4 inhibition and tryptophan metabolic crosstalk. Biomaterials. 2025;321:123339. https://doi.org/10.1016/j.biomaterials.2025.123339.
Article
PubMed
Google Scholar
Bian D-D, Liu X, Jiang J-J, Sun X-L, Shi Y-X, Zhu X-R, et al. An insight into nitrite-induced reproductive toxicity and the alleviation of injury by selenomethionine through activation of the Keap1/Nrf2 pathway in Procambarus clarkii. Int J Biol Macromol. 2025;306:141616. https://doi.org/10.1016/j.ijbiomac.2025.141616.
Article
PubMed
Google Scholar
Qi X, Tong L, Lian H, Chen Z, Yang L, Wu Y, et al. Selenium nanoparticles modified with Ophiocordyceps gracilis polysaccharides: enhancing stability, bioavailability, and anti-inflammatory efficacy. Food Res Int. 2025;201:115652. https://doi.org/10.1016/j.foodres.2024.115652.
Article
PubMed
Google Scholar
Huang L, Zhang S, Bian M, Xiang X, Xiao L, Wang J, et al. Injectable, anti-collapse, adhesive, plastic and bioactive bone graft substitute promotes bone regeneration by moderating oxidative stress in osteoporotic bone defect. Acta Biomater. 2024;180:82–103. https://doi.org/10.1016/j.actbio.2024.04.016.
Article
PubMed
Google Scholar
Zheng G, Xu X, Zheng J, Liu A. Protective effect of seleno-β-lactoglobulin (Se-β-lg) against oxidative stress in D-galactose-induced aging mice. J Funct Foods. 2016;27:310–8. https://doi.org/10.1016/j.jff.2016.09.015.
Article
Google Scholar
Huang Y, Liu C, Pu F, Liu Z, Ren J, Qu X. A GO–Se nanocomposite as an antioxidant nanozyme for cytoprotection. Chem Commun. 2017;53:3082–5. https://doi.org/10.1039/c7cc00045f.
Article
Google Scholar
Ou L, Wu Z, Hu X, Huang J, Yi Z, Gong Z, Li H, Peng K, Shu C, Koole LH. A tissue-adhesive F127 hydrogel delivers antioxidative copper-selenide nanoparticles for the treatment of dry eye disease. Acta Biomater. 2024;175:353–68. https://doi.org/10.1016/j.actbio.2023.12.021.
Article
PubMed
Google Scholar
Bai K, Hong B, He J, Hong Z, Tan R. Preparation and antioxidant properties of selenium nanoparticles-loaded chitosan microspheres. Int J Nanomed. 2017. https://doi.org/10.2147/ijn.s129958.
Article
Google Scholar
Lai H, Zhang X, Song Z, Yuan Z, He L, Chen T. Facile synthesis of antioxidative nanotherapeutics using a microwave for efficient reversal of cisplatin-induced nephrotoxicity. Chem Eng J. 2019. https://doi.org/10.1016/j.cej.2019.123563.
Article
Google Scholar
Sardar R, Ahmed S, Shah AA, Yasin NA. Selenium nanoparticles reduced cadmium uptake, regulated nutritional homeostasis and antioxidative system in Coriandrum sativum grown in cadmium toxic conditions. Chemosphere. 2022;287:132332. https://doi.org/10.1016/j.chemosphere.2021.132332.
Article
PubMed
Google Scholar
Liu K, Du R, Chen F. Stability of the antioxidant peptide SeMet-Pro-Ser identified from selenized brown rice protein hydrolysates. Food Chem. 2020;319:126540. https://doi.org/10.1016/j.foodchem.2020.126540.
Article
PubMed
Google Scholar
Jassim A, Rahrmann EP, Simons BD, Gilbertson RJ. Cancers make their own luck: theories of cancer origins. Nat Rev Cancer. 2023;23:710–24. https://doi.org/10.1038/s41568-023-00602-5.
Article
PubMed
Google Scholar
Abdifetah O, Na-Bangchang K. Pharmacokinetic studies of nanoparticles as a delivery system for conventional drugs and herb-derived compounds for cancer therapy: a systematic review. Int J Nanomed. 2019. https://doi.org/10.2147/ijn.s213229.
Article
Google Scholar
Yao Y, Li P, He J, Wang D, Hu J, Yang X. Albumin-templated Bi2Se3-MnO2 nanocomposites with promoted catalase-like activity for enhanced radiotherapy of cancer. ACS Appl Mater Interfaces. 2021;13:28650–61. https://doi.org/10.1021/acsami.1c05669.
Article
PubMed
Google Scholar
Purohit MP, Verma NK, Kar AK, Singh A, Ghosh D, Patnaik S. Inhibition of thioredoxin reductase by targeted selenopolymeric nanocarriers synergizes the therapeutic efficacy of doxorubicin in MCF7 human breast cancer cells. ACS Appl Mater Interfaces. 2017;9:36493–512. https://doi.org/10.1021/acsami.7b07056.
Article
PubMed
Google Scholar
Xu C, Qiao L, Guo Y, Ma L, Cheng Y. Preparation, characteristics and antioxidant activity of polysaccharides and proteins-capped selenium nanoparticles synthesized by Lactobacillus casei ATCC 393. Carbohydr Polym. 2018;195:576–85. https://doi.org/10.1016/j.carbpol.2018.04.110.
Article
PubMed
Google Scholar
Wang Y, Wang J, Hao H, Cai M, Wang S, Ma J, et al. In vitro and in vivo mechanism of bone tumor inhibition by selenium-doped bone mineral nanoparticles. ACS Nano. 2016;10:9927–37. https://doi.org/10.1021/acsnano.6b03835.
Article
PubMed
PubMed Central
Google Scholar
Du J, Gu Z, Yan L, Yong Y, Yi X, Zhang X, et al. Poly(Vinylpyrollidone)- and Selenocysteine-modified Bi2Se3 nanoparticles enhance radiotherapy efficacy in tumors and promote radioprotection in normal tissues. Adv Mater. 2017;29:1701268. https://doi.org/10.1002/adma.201701268.
Article
Google Scholar
Wang X, Zhong X, Lei H, Geng Y, Zhao Q, Gong F, et al. Hollow Cu2Se nanozymes for tumor photothermal-catalytic therapy. Chem Mater. 2019;31:6174–86. https://doi.org/10.1021/acs.chemmater.9b01958.
Article
Google Scholar
Lv Y, Liu K, Liu D, Qu Y, Dai Y, Zhu Z, et al. Oral nanomedicine for cure of T2DM through whole-process regulation of glucose uptake/metabolism and mitochondrial repair in hepatocytes. Chem Eng J. 2025;166218. https://doi.org/10.1016/j.cej.2025.166218.
Article
Google Scholar
Dilworth L, Stennett D, Facey A, Omoruyi F, Mohansingh S, Omoruyi FO. Diabetes and the associated complications: the role of antioxidants in diabetes therapy and care. Biomed Pharmacother. 2024;181:117641. https://doi.org/10.1016/j.biopha.2024.117641.
Article
PubMed
Google Scholar
Sasaki M, Fujimoto S, Sato Y, Nishi Y, Mukai E, Yamano G, et al. Reduction of reactive oxygen species ameliorates metabolism-secretion coupling in islets of diabetic gk rats by suppressing lactate overproduction. Diabetes. 2013;62:1996–2003. https://doi.org/10.2337/db12-0903.
Article
PubMed
PubMed Central
Google Scholar
Polianskyte-Prause Z, Tolvanen TA, Lindfors S, Kon K, Hautala LC, Wang H, Wada T, Tsuneki H, Sasaoka T, Lehtonen S. Ebselen enhances insulin sensitivity and decreases oxidative stress by inhibiting SHIP2 and protects from inflammation in diabetic mice. Int J Biol Sci. 2022;18:1852–64. https://doi.org/10.7150/ijbs.66314.
Article
PubMed
PubMed Central
Google Scholar
Sies H, Jones DP. Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol. 2020;21:363–83. https://doi.org/10.1038/s41580-020-0230-3.
Article
PubMed
Google Scholar
Huang Q, Liu Z, Yang Y, Yang Y, Huang T, Hong Y, et al. Selenium nanodots (SENDs) as antioxidants and antioxidant-prodrugs to rescue islet β cells in type 2 diabetes mellitus by restoring mitophagy and alleviating endoplasmic reticulum stress. Adv Sci. 2023;10:2300880. https://doi.org/10.1002/advs.202300880.
Article
Google Scholar
Li X, Ma L, Zheng W, Chen T. Inhibition of islet amyloid polypeptide fibril formation by selenium-containing phycocyanin and prevention of beta cell apoptosis. Biomaterials. 2014;35:8596–604. https://doi.org/10.1016/j.biomaterials.2014.06.056.
Article
PubMed
Google Scholar
Wu J, Meng T, Zhang X, Tang S, Liu L, Xue J, et al. Glucose-responsive Zn(II)-porphyrin COF adhesive hydrogels with dual-active sites and GOX-like activity for accelerated wound healing. Adv Healthc Mater. 2025;14:2404076. https://doi.org/10.1002/adhm.202404076.
Article
Google Scholar
Wu Z, Hou Q, Qin L, Chen T, Yang K, Wei F, et al. Gpx-mimetic selenium-enriched yeast nanozymes ameliorate diabetic bone disease via dual-targeting of ROS scavenging and angiogenesis-osteogenesis coupling. Mater Today Bio. 2025;32:101836. https://doi.org/10.1016/j.mtbio.2025.101836.
Article
PubMed
PubMed Central
Google Scholar
Ishikura K, Misu H, Kumazaki M, Takayama H, Matsuzawa-Nagata N, Tajima N, et al. Selenoprotein p as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells. Diabetologia. 2014;57:1968–76. https://doi.org/10.1007/s00125-014-3306-9.
Article
PubMed
Google Scholar
Jeffcoate W, Boyko EJ, Game F, Cowled P, Senneville E, Fitridge R. Causes, prevention, and management of diabetes-related foot ulcers. Lancet Diabetes Endocrinol. 2024;12:472–82. https://doi.org/10.1016/s2213-8587(24)00110-4.
Article
PubMed
Google Scholar
Wei T, Pan T, Peng X, Zhang M, Guo R, Guo Y, Mei X, Zhang Y, Qi J, Dong F, et al. Janus liposozyme for the modulation of redox and immune homeostasis in infected diabetic wounds. Nat Nanotechnol. 2024;19:1178–89. https://doi.org/10.1038/s41565-024-01660-y.
Article
PubMed
Google Scholar
Su Z, Chen Y, Liang H, Liu Z, Wu D, Li J, et al. Decellularized periosteum and sodium alginate-based photoresponsive dressing with copper selenide nanoparticles for infected-wound healing in diabetic mice. Int J Biol Macromol. 2024;268:131895. https://doi.org/10.1016/j.ijbiomac.2024.131895.
Article
PubMed
Google Scholar
Shen Y, Li S, Hou X, Yu J, Zhu Y, Zhao C, et al. Ultrasound-triggered nanocomposite lever hydrogels with a full repair system accelerates diabetic foot ulcer repair. Adv Sci. 2025;12:2500720. https://doi.org/10.1002/advs.202500720.
Article
Google Scholar
Yang L, Zhang D, Li W, Lin H, Ding C, Liu Q, et al. Biofilm microenvironment triggered self-enhancing photodynamic immunomodulatory microneedle for diabetic wound therapy. Nat Commun. 2023;14:7658. https://doi.org/10.1038/s41467-023-43067-8.
Article
PubMed
PubMed Central
Google Scholar
Zhao N, Yuan W. Self-healing and shape-adaptive nanocomposite hydrogels with anti-inflammatory, antioxidant, antibacterial activities and hemostasis for real-time visual regeneration of diabetic wounds. Compos Part B: Eng. 2023;262:110819. https://doi.org/10.1016/j.compositesb.2023.110819.
Article
Google Scholar
Zhang Z, Zhang Y, Peng L, Xing Y, Zhou X, Zheng S, et al. Multifunctional dual-layer microneedles loaded with selenium-doped carbon quantum dots and Astilbin for ameliorating diabetic wound healing. Mater Today Bio. 2025;32:101739. https://doi.org/10.1016/j.mtbio.2025.101739.
Article
PubMed
PubMed Central
Google Scholar
Li W, Bei Y, Pan X, Zhu J, Zhang Z, Zhang T, et al. Selenide-linked polydopamine-reinforced hybrid hydrogels with on-demand degradation and light-triggered nanozyme release for diabetic wound healing. Biomater Res. 2023;27:49. https://doi.org/10.1186/s40824-023-00367-w.
Article
PubMed
PubMed Central
Google Scholar
Liu Y, Yang M, Li Y, Liu Y, Su H, Zhang W, et al. A multifunctional living hydrogel for the synergistic management of infected diabetic wounds. Mater Today Bio. 2025;32:101787. https://doi.org/10.1016/j.mtbio.2025.101787.
Article
PubMed
PubMed Central
Google Scholar
Ransohoff RM. How neuroinflammation contributes to neurodegeneration. Science. 2016;353:777–83. https://doi.org/10.1126/science.aag2590.
Article
PubMed
Google Scholar
Zhang R, Chen X, Cheng Y, Chen Z, Li X, Deng Y. Recent advances of nanomaterials for intervention in Parkinson’s disease in the context of anti-inflammation. Coord Chem Rev. 2024;502:215616. https://doi.org/10.1016/j.ccr.2023.215616.
Article
Google Scholar
Liu X, Jesus S-G, Kong Z, Fan N, Mi Y, Wang Q, et al. Polysaccharide nano–selenium in the regulation of neuroinflammation: a review of mechanisms, functional potential, and activity evaluation. Carbohydr Polym. 2025;366:123833. https://doi.org/10.1016/j.carbpol.2025.123833.
Article
PubMed
Google Scholar
Zhou F, He Y, Zhang M, Gong X, Liu X, Tu R, Yang B. Polydopamine(PDA)-coated diselenide-bridged mesoporous silica-based nanoplatform for neuroprotection by reducing oxidative stress and targeting neuroinflammation in intracerebral hemorrhage. J Nanobiotechnol. 2024;22:731. https://doi.org/10.1186/s12951-024-03023-0.
Article
Google Scholar
Geng X, Liu K, Li P, Xing H, Pei X, Chang J, et al. A multipronged strategy for encephalitis: oxidative stress reduction and inflammatory microenvironment modulation by a neuroprotective selenium-based nanomedicine. Chem Eng J. 2024;492:152176. https://doi.org/10.1016/j.cej.2024.152176.
Article
Google Scholar
Gong Y, Huang A, Guo X, Jia Z, Chen X, Zhu X, Xia Y, Liu J, Xu Y, Qin X. Selenium-core nanozymes dynamically regulates Aβ & neuroinflammation circulation: augmenting repair of nervous damage. Chem Eng J. 2021;418:129345. https://doi.org/10.1016/j.cej.2021.129345.
Article
Google Scholar
Wang J, Wang Z, Li Y, Hou Y, Yin C, Yang E, et al. Blood brain barrier-targeted delivery of double selenium nanospheres ameliorates neural ferroptosis in Alzheimer’s disease. Biomaterials. 2023;302:122359. https://doi.org/10.1016/j.biomaterials.2023.122359.
Article
PubMed
Google Scholar
Zhang C, Wang H, Liang W, Yang Y, Cong C, Wang Y, et al. Diphenyl diselenide protects motor neurons through inhibition of microglia-mediated inflammatory injury in amyotrophic lateral sclerosis. Pharmacol Res. 2021;165:105457. https://doi.org/10.1016/j.phrs.2021.105457.
Article
PubMed
Google Scholar
Liu J, Mai L, Tan A, Du Y, Luo J, Xu S, et al. Self-enhancing drug pair-driven selenium nanotherapeutics reverses microglial pyroptosis through NLRP3/caspase-1 pathway and neuronal apoptosis for treatment of spinal cord injury. Adv Funct Mater. 2025. https://doi.org/10.1002/adfm.202503505.
Article
PubMed
Google Scholar
Rao S, Lin Y, Lin R, Liu J, Wang H, Hu W, Chen B, Chen T. Traditional Chinese medicine active ingredients-based selenium nanoparticles regulate antioxidant selenoproteins for spinal cord injury treatment. J Nanobiotechnol. 2022;20:278. https://doi.org/10.1186/s12951-022-01490-x.
Article
Google Scholar
Ji Z, Zheng J, Ma Y, Lei H, Lin W, Huang J, et al. Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual-signal transform-based selenium antioxidant. Small. 2023;19:2207888. https://doi.org/10.1002/smll.202207888.
Article
Google Scholar
Li C, Wu Y, Chen Q, Luo Y, Liu P, Zhou Z, Zhao Z, Zhang T, Su B, Sun T, Jiang C. Pleiotropic microenvironment remodeling micelles for cerebral ischemia-reperfusion injury therapy by inhibiting neuronal ferroptosis and glial overactivation. ACS Nano. 2023;17:18164–77. https://doi.org/10.1021/acsnano.3c05038.
Article
PubMed
Google Scholar
Kong J, Zou R, Chu R, Hu N, Liu J, Sun Y, et al. An ultrasmall Cu/Cu2O nanoparticle-based diselenide-bridged nanoplatform mediating reactive oxygen species scavenging and neuronal membrane enhancement for targeted therapy of ischemic stroke. ACS Nano. 2024;18:4140–58. https://doi.org/10.1021/acsnano.3c08734.
Article
PubMed
Google Scholar
Wang Y, Liao X, Guo Q, Zhang H, Ye L, Yu L, Kong X, Jiang Y, Zhao P, Cai K, Cheng H. Dual-pathway targeted therapy for parkinson’s disease: biomimetic nanosomes inhibit ferroptosis and pyroptosis through NLRP3 inflammasome regulation. Bioactive Mater. 2025;51:825–40. https://doi.org/10.1016/j.bioactmat.2025.06.033.
Article
Google Scholar
Cao B, Zhang H, Sun M, Xu C, Kuang H, Xu L. Chiral MoSe2 nanoparticles for ultrasensitive monitoring of reactive oxygen species in vivo. Adv Mater. 2024;36:2208037. https://doi.org/10.1002/adma.202208037.
Article
Google Scholar
Jo HJ, Im G-B, Robby AI, In I, Bhang SH, Shit A, et al. ROS-responsive mechanically and electronically controllable conductive hydrogel sensor with NIR modulated photothermal therapy. Chem Eng J. 2023;455:140729. https://doi.org/10.1016/j.cej.2022.140729.
Article
Google Scholar
Kim SG, Ryplida B, Giang NN, Lee G, Lee KD, Park SY. Tuning conductivity and roughness of diselenide polymer dot-coated surface for ROS-mediated selective real-time wireless detection of cancer cells. Chem Eng J. 2021;426:130880. https://doi.org/10.1016/j.cej.2021.130880.
Article
Google Scholar
Benson S, Kiang A, Lochenie C, Lal N, Mohanan SMPC, Williams GOS, Dhaliwal K, Mills B, Vendrell M. Environmentally sensitive photosensitizers enable targeted photodynamic ablation of Gram-positive antibiotic resistant bacteria. Theranostics. 2023;13:3814–25. https://doi.org/10.7150/thno.84187.
Article
PubMed
PubMed Central
Google Scholar
Gao F, Pang Y, Wang Y, Yang X, Song W, Nie X, et al. Nanocellulose/selenoglutathione-enhanced antioxidant, elastic, antibacterial, and conductive hydrogels as strain sensors. ACS Sustain Chem Eng. 2024;12:13622–33. https://doi.org/10.1021/acssuschemeng.4c04986.
Article
Google Scholar
Ma X, Fan Z, Peng J, Nie L. Ischemic area-targeting and self-monitoring nanoprobes ameliorate myocardial ischemia/reperfusion injury by scavenging ROS and counteracting cardiac inflammation. Adv Sci. 2025;12:2414518. https://doi.org/10.1002/advs.202414518.
Article
Google Scholar
Subba SH, Jiang S, Jin E-J, Park SY. Hypoxia-sensitive smart hydrogel biosensor for distinct mechanical and electrical signals with muscle ischemia regeneration. Adv Funct Mater. 2025;2417935. https://doi.org/10.1002/adfm.202417935. n/a.
Waypa GB, Chandel NS, Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res. 2001;88:1259–66. https://doi.org/10.1161/hh1201.091960.
Article
PubMed
Google Scholar
Zhang X, He C, Yan R, Chen Y, Zhao P, Li M, et al. HIF-1 dependent reversal of cisplatin resistance via anti-oxidative nano selenium for effective cancer therapy. Chem Eng J. 2020;380:122540. https://doi.org/10.1016/j.cej.2019.122540.
Article
Google Scholar
Chen C, Ma J, Duan S, Xue M, Yang Z, Ma Z, Ji J, Ma Y, Qing G, Guo K, et al. Mitigation of ischemia/reperfusion injury via selenium nanoparticles: suppression of STAT1 to inhibit cardiomyocyte oxidative stress and inflammation. Biomaterials. 2025;318:123119. https://doi.org/10.1016/j.biomaterials.2025.123119.
Article
PubMed
Google Scholar
Quispe RL, Jaramillo ML, Galant LS, Engel D, Dafre AL, Teixeira da Rocha JB, Radi R, Farina M, de Bem AF. Diphenyl diselenide protects neuronal cells against oxidative stress and mitochondrial dysfunction: involvement of the glutathione-dependent antioxidant system. Redox Biol. 2019;20:118–29. https://doi.org/10.1016/j.redox.2018.09.014.
Article
PubMed
Google Scholar
Li X, Wang Y, Chen Y, Zhou P, Wei K, Wang H, et al. Hierarchically constructed selenium-doped bone-mimetic nanoparticles promote ROS-mediated autophagy and apoptosis for bone tumor inhibition. Biomaterials. 2020;257:120253. https://doi.org/10.1016/j.biomaterials.2020.120253.
Article
PubMed
Google Scholar
Zhang Y, Hu M, Zhang W, Zhang X. Construction of tellurium-doped mesoporous bioactive glass nanoparticles for bone cancer therapy by promoting ROS-mediated apoptosis and antibacterial activity. J Colloid Interface Sci. 2022;610:719–30. https://doi.org/10.1016/j.jcis.2021.11.122.
Article
PubMed
Google Scholar
Zhai Z, Ouyang W, Yao Y, Zhang Y, Zhang H, Xu F, et al. Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury. Bioact Mater. 2022;14:430–42. https://doi.org/10.1016/j.bioactmat.2022.01.047.
Article
PubMed
PubMed Central
Google Scholar
Zhu R, He Q, Li Z, Ren Y, Liao Y, Zhang Z, et al. ROS-cleavable diselenide nanomedicine for NIR-controlled drug release and on-demand synergistic chemo-photodynamic therapy. Acta Biomater. 2022;153:442–52. https://doi.org/10.1016/j.actbio.2022.09.061.
Article
PubMed
Google Scholar
Xu J, Chu T, Yu T, Li N, Wang C, Li C, et al. Design of diselenide-bridged hyaluronic acid nano-antioxidant for efficient ROS scavenging to relieve colitis. ACS Nano. 2022;16:13037–48. https://doi.org/10.1021/acsnano.2c05558.
Article
PubMed
Google Scholar
Xie B, Zeng D, Yang M, Tang Z, He L, Chen T. Translational selenium nanoparticles to attenuate allergic dermatitis through Nrf2-Keap1-driven activation of selenoproteins. ACS Nano. 2023;17:14053–68. https://doi.org/10.1021/acsnano.3c04344.
Article
PubMed
Google Scholar
Worldwide.espacenet.com, Self-assembled selenium peptide nano material for targeting mitochondria as well as preparation method and application of self-assembled selenium peptide nano material, 2023, CN116350615A.
Worldwide.espacenet.com. Selenium-coated zinc/cerium-based nano-enzyme and application thereof in regulating intestinal microenvironment to treat inflammatory bowel disease. CN119454614A; 2024.
Worldwide.espacenet.com. Use of nano-selenium cordyceps militaris aqueous extract in reducing radiotherapy injury and protective agent, WO2023082217A1.
ClinicalTrials.gov, Selenium and Prostate Cancer: Clinical Trial on Availability to Prostate Tissue and Effects on Gene Expression, 2011, NCT00446901.
ClinicalTrials.gov, Selenium and Prostate Cancer: Clinical Trial on Availability to Prostate Tissue and Effects on Gene Expression, 2021, NCT04005222.
ClinicalTrials.gov, Selenium in the Prevention of Cancer. 2015, NCT00022165.
Feng R, Wang L, Yang J, Zhao P, Zhu Y, Li Y, et al. Underlying mechanisms responsible for restriction of uptake and translocation of heavy metals (metalloids) by selenium via root application in plants. J Hazard Mater. 2021;402:123570. https://doi.org/10.1016/j.jhazmat.2020.123570.
Article
PubMed
Google Scholar
Smith PJ, Tappel AL, Chow CK. Glutathione peroxidase activity as a function of dietary selenomethionine. Nature. 1974;247:392–3. https://doi.org/10.1038/247392a0.
TOKYO, Nov 11 (Reuters) – Japan’s industry ministry is seeking changes to the law so that public money can be used for investment in the nuclear power sector and in electricity grids, the Nikkei business daily reported on Tuesday.
New Prime Minister Sanae Takaichi has said reviving nuclear power is key to Japan’s energy security and the industry wants greater support for new reactor building, particularly as the boom in artificial intelligence and data centres spurs demand for more electricity.
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The ministry aims to present a proposal to a working group with the hope that a bill to amend the law will be passed in parliament next year.
In July, Kansai Electric Power (9503.T), opens new tab, Japan’s top nuclear power operator, announced it was conducting initial studies to build a new reactor in western Japan – the first concrete step towards building a reactor since the Fukushima Daiichi nuclear plant meltdowns in 2011.
Reporting by Katya Golubkova; Editing by Edwina Gibbs
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A new real-world study reveals that advanced GLP-1 therapies, including semaglutide and tirzepatide, provide comparable glycemic control while offering superior weight benefits compared to metformin in adolescents newly diagnosed with type 2 diabetes.
Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study. Image Credit: Meteoritka / Shutterstock
In a recent study published in the Journal of Pediatric Endocrinology and Metabolism, researchers compared the efficacy of metformin and GLP-1–based therapies, including GLP-1 receptor agonists and the dual GIP/GLP-1 agonist tirzepatide, in youth newly diagnosed with type 2 diabetes (T2D).
Aggressive Nature and Treatment Challenges of Youth-Onset T2D
Youth-onset T2D progresses rapidly, with early onset of complications in adulthood. Metformin remains the first-line therapy for newly diagnosed pediatric patients; however, while it effectively lowers glycated hemoglobin (HbA1c), it has minimal effects on weight loss and limited durability in glycemic control. GLP-1–based therapies, already recommended in adults, are gaining traction in younger populations due to their glucose-lowering and weight-reducing effects.
Rationale for Exploring High-Potency GLP-1 Therapies
Several GLP-1 receptor agonists are approved for pediatric T2D, supported by guidelines as adjunctive treatments to metformin. Yet, approved pediatric doses yield modest weight benefits. This has prompted investigation into higher-potency GLP-1RAs and monotherapy approaches, including dual incretin agents such as tirzepatide, to assess whether stronger metabolic effects can be achieved in this age group.
Study Design and Population Characteristics
This retrospective, real-world study extracted data from electronic medical records of an urban pediatric hospital. Eligible participants were youth with newly diagnosed T2D who received GLP-1RA or metformin monotherapy between January 2022 and March 2024. Exclusion criteria included combination therapy, insulin as first-line treatment, and diabetes secondary to other causes.
Collected variables included demographics, diabetes duration, BMI, HbA1c, BMI z-scores, medication type and dose, and adverse effects. All participants were publicly insured. The primary outcomes were monthly changes in HbA1c and percent BMI within the first year post-diagnosis, with secondary outcomes assessing median changes in HbA1c, BMI, and z-scores.
Baseline Demographics and Medication Profiles
A total of 125 youth were included (median age 14.83 years), with 113 on metformin and 12 on GLP-1RA therapy. The GLP-1RA group was predominantly female (83%) compared to 51% in the metformin group, and fewer individuals identified as Latino (41.7% vs 69.9%). The most prescribed GLP-1RA was semaglutide 1 mg (33%), followed by tirzepatide 7.5 mg (25%). Higher-potency formulations (semaglutide up to 2.4 mg and tirzepatide) were used, which may account for stronger weight effects compared to pediatric trials that employed lower doses. Seven GLP-1RA recipients reported gastrointestinal adverse effects such as nausea, vomiting, and constipation.
Comparative Glycemic and Anthropometric Outcomes
Baseline HbA1c levels were similar across groups. At follow-up, unadjusted analyses showed lower HbA1c in the GLP-1RA group (36 vs 44 mmol/mol, p = 0.03), but adjusted models revealed no statistically significant monthly HbA1c change (β −1.1, p = 0.308). Median HbA1c decreased by 8.7 mmol/mol with metformin and 14.2 mmol/mol with GLP-1RA therapy.
Regarding weight outcomes, GLP-1RA recipients exhibited greater BMI reduction (−0.43 kg/m² per month) compared with metformin (−0.01 kg/m² per month). Adjusted regression analysis indicated an approximately 1% additional monthly BMI reduction with GLP-1 therapy (β = −1.08%, p = 0.001). Final percent BMI reduction was −5.1% for GLP-1RA and −0.59% for metformin, with corresponding z-score decreases of −0.02 and −0.01, respectively.
Interpretation of Efficacy and Safety Findings
At study completion, 83% of GLP-1RA users and 67% of metformin users achieved the target HbA1c of 48 mmol/mol. Although glycemic control was comparable, GLP-1RA therapy conferred superior weight reduction benefits. Adverse events were limited to gastrointestinal symptoms, consistent with the known pharmacological effects of GLP-1. The small sample size of the GLP-1RA, however, limits generalizability, and baseline BMI differences may have influenced the observed outcomes.
Study Limitations and Future Research Directions
The interpretation of the findings is limited by the small GLP-1RA cohort (n = 12), baseline imbalances in BMI and sex, the single-center retrospective design, incomplete autoantibody testing, and a median follow-up of approximately eight months. Larger, multicenter trials with balanced cohorts and extended follow-up are required to confirm comparative effects on HbA1c sustainability, beta-cell preservation, and insulin sensitivity.
Journal reference:
Tejeji I., Zeier T., Smith J. A., Chang N. T., Chao L. C. (2025). Exploratory real-world experience with GLP-1 receptor agonists vs. metformin in youth with new-onset type 2 diabetes: a single-center retrospective study. Journal of Pediatric Endocrinology and Metabolism. DOI: 10.1515/jpem-2025-0493, https://www.degruyterbrill.com/document/doi/10.1515/jpem-2025-0493/html
The safe-haven yen was pinned near its weakest levels for months on Tuesday while riskier currencies were firm against the dollar.
Sutthipong Kongtrakool | Moment | Getty Images
The safe-haven yen hit its lowest since February on Tuesday while riskier currencies were firm against the dollar, as traders waited to see whether U.S. lawmakers could secure an end to the government shutdown in coming days.
The euro was steady at $1.1558 and sterling has been creeping higher to $1.3177.
A deal that would restore U.S. federal funding, and end the longest shutdown on record, cleared an initial Senate hurdle late on Sunday, though it was unclear when Congress would give its final approval.
A gain of about 0.7% for the Australian dollar to $0.6536 and a drop in the yen to 154.11 per dollar were the biggest movers in the wake of the breakthrough. The yen briefly touched 154.49 per dollar in morning trade, its weakest since February.
Analysts said their moves could be vulnerable to reversal if the path to inking the shutdown deal dragged much beyond this week. There are still several Senate hurdles to clear.
House of Representatives Speaker Mike Johnson said his chamber could pass the bill as soon as Wednesday and send it on to President Donald Trump to sign into law, if the Senate acts quickly.
“Reopening by November 15 is just about fully priced in for now, so any deviation or delays from that could be viewed as risky for this rebound in liquidity,” said Brent Donnelly, president at analytics firm Spectra Markets.
New Zealand inflation expectations, British weekly wage data and Germany’s ZEW sentiment survey are due later in the session.
The New Zealand dollar has been under pressure for months as the economy slows and had on Tuesday hit a 12-year low against the Australian dollar, reflecting a divergent outlook for interest rates in the Antipodes.
BOGOTA, Colombia, Nov. 10, 2025 /PRNewswire/ — Ecopetrol S.A. (BVC: ECOPETROL; NYSE: EC) announces that it has published its first 2024 Financial Sustainability Report, in line with its commitment to transparency, sustainable value creation, and a fair and equitable energy transition for the country.
This document marks a milestone in the evolution of sustainability disclosure practices by consolidating the content previously presented separately under the recommendations of the Task Force on Climate-related Financial Disclosures (TCFD) and the metrics of the Sustainability Accounting Standards Board (SASB) into a single report, incorporating reference elements from the International Sustainability Standards Board (“ISSB“) framework.
This unified report has been implemented in response to the need to simplify, standardize, and enhance the value of sustainability information disclosed to the market. It is structured around the Ecopetrol’s pillars of governance, strategy, risk and opportunity management, metrics, and targets.
The full report is available at the following link:
Ecopetrol is the largest company in Colombia and one of the main integrated energy companies in the American continent, with more than 19,000 employees. In Colombia, it is responsible for more than 60% of the hydrocarbon production of most transportation, logistics, and hydrocarbon refining systems, and it holds leading positions in the petrochemicals and gas distribution segments. With the acquisition of 51.4% of ISA’s shares, the company participates in energy transmission, the management of real-time systems (XM), and the Barranquilla – Cartagena coastal highway concession. At the international level, Ecopetrol has a stake in strategic basins in the American continent, with Drilling and Exploration operations in the United States (Permian basin and the Gulf of Mexico), Brazil, and, through ISA and its subsidiaries, Ecopetrol holds leading positions in the power transmission business in Brazil, Chile, Peru, and Bolivia, road concessions in Chile, and the telecommunications sector.
For more information, please contact:
Head of Capital Markets Carolina Tovar Aragón Email: [email protected]
Head of Corporate Communications Marcela Ulloa Email: [email protected]
Homeowners in Southeast Asia today are paying greater attention to creating modern living spaces of their very own. With increasing interest in both form and function, they are making design choices that more closely intertwine with technology, comfort, and seamless connectivity.
Cooling is one such aspect, which is fundamental to many Southeast Asian homes located in humid tropical climates – for instance, 2025 has been Malaysia’s hottest year in its modern history, with extreme temperatures ranging from 40°C to 45°C[1]. Meanwhile, Northern Vietnam experienced record high temperatures in August 2025, with Hanoi hitting peak temperature at 40.3°C[2]. Naturally, air-conditioners play a critical role in the modern home, providing not only essential comfort but also offering the potential to enhance design harmony and lifestyles through effortless connection, customization, and control.
Shifting Home Design and Interior Aesthetics
When it comes to home design, minimalist, open-plan homes with full-height windows and panoramic glass walls are gaining popularity amongst Southeast Asian consumers. However, these homes often feature square-shaped living areas, making it challenging to identify a suitable wall space for air conditioners without compromising on interior design.
Ceiling-mounted air conditioners are easily incorporated into ceilings, without disrupting design aesthetics
Traditional wall-mounted air conditioners often disrupt intended aesthetics, requiring large sections of uninterrupted wall space, resulting in inflexible interior and potential clash with modern décor. It is no surprise then, that ceiling-mounted system air conditioners (SACs) are emerging as the preferred alternative.
As Jenny Baek, Vice-President and Head of the Air Solution Business Group at Samsung Electronics, explains: “Even if someone isn’t installing floor-to-ceiling glass, they may still want to keep their walls flexible, and system air conditioners give them that freedom”.
In fact, in a recent survey[3], 84% of Thai system air conditioner users expressed high satisfaction, citing effective cooling for large areas and less impact on interior aesthetics as the main benefits.
With flexible installation, WindFree™ cooling and an intelligent AI system, the WindFree 1Way Cassette is built to meet the demands of stylish, comfortable living.
Samsung’s WindFree 1Way Cassette is an ideal choice to meet such needs. Featuring WindFree™ technology to effectively maintain a comfortable level of coolness without any unpleasant cold drafts, the air-conditioner disperses cool air through 10,000 micro air holes. Meanwhile its ultra-slim silhouette fits seamlessly into ceiling and blends effortlessly into modern interiors – freeing up walls for art, shelves or curtains and delivering clean, quiet and sleek comfort.
It’s evident that comfort and style are rising priorities for consumers in the region. In 2024, Samsung’s system air conditioner sales in Southeast Asia rose by over 20% from the previous year, with sales of the one-way cassette model alone jumping more than 35%.
Powering Effortless and Smart Living
Beyond design, intuitiveness, adaptiveness, and sustainable use are key for homeowners, with consumers in the Philippines citing energy efficiency and upgraded features as the two most important factors for consideration when purchasing new air-conditioners[4].
Effortlessly control the WindFree 1Way Cassette with Samsung SmartThings App
Equipped with built-in Wi-Fi, the WindFree 1Way Cassette works seamlessly with SmartThings to enable all-day comfort, offering centralized control over settings and performance. Working in the background, features like SmartThings Al Energy Mode can automatically adjust settings to reduce energy use by up to 20%[5] for cost and energy savings. Meanwhile, Comfort Humidity Control monitors temperature and humidity to maintain a steady indoor climate.
Designed to offer convenience and effortless support for daily life, the WindFree 1Way Cassette can be configured to switch on automatically when one is on the way home with Welcome Cooling[6]. It can also connect seamlessly to wearable devices like Samsung’s Galaxy Watch or Ring, to track sleep cycles and optimize room temperatures with the AI-powered Good Sleep Mode[7].
In-store Experiences to Make Informed Choices
Traditionally, system air conditioners (SACs) were installed primarily in commercial spaces such as offices, hotels, or large stores, and therefore promoted through specialized distributors or catalogues rather than in general retail environments. However, in the same Samsung research survey[8], customers – for example, those in Thailand – who expressed an intention to purchase system air conditioners also wanted the ability to see and compare them in person, at general electronics stores or large supermarkets, not just through catalogues or installers.
Responding to this shift, Samsung introduced in-store displays for its system air conditioners in Southeast Asia starting in June earlier this year. Shoppers can now view, compare, and purchase models directly at large electronics retailers and supermarkets. The pilot program launched in select locations in Thailand, including Siam Paragon mall, generated overwhelming consumer response.
In-store display of WindFree 1Way Cassette at Siam Paragon Mall
More Southeast Asian consumers can look forward to new opportunities to explore the product portfolio, with Samsung expanding in-store SAC displays to six Southeast Asian markets including Vietnam, Indonesia, Thailand, Philippines and Malaysia this year. Interested consumers are now able to pop into participating stores to experience the technology firsthand and enjoy greater flexibility in how they cool their homes.
For more information, please visit: https://news.samsung.com/my/
[1]Climate crisis deepens as Malaysia hits 45°C
[2]Record heatwave blasts northern Vietnam
[3] Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.
[4] Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.
[5] Requires the use of SmartThings app and a Samsung account. Actual savings may vary by usage patterns and environment. Savings realized from comparison of power consumption with AI Energy Mode on and off, using AI Comfort Cooling mode at 24°C for cooling and 22°C for heating.
[6] This function may be affected by the GPS conditions.
[7] It can be used when linking a Samsung smartphone with Samsung software One Ul version 4.0 or later and a wearable device that supports Wear OS: Galaxy Watch 4 or later, Fit 3 or later, Galaxy Ring. You must download the Samsung SmartThings App on the wearable device and connect the air conditioner to your home Wi-Fi.
[8] Based on the Samsung 1-way cassette AC Study in Southeast Asia conducted across two markets, Thailand and the Philippines, from November to December 2024.
TOKYO, Nov 11 (Reuters) – Japanese financial services firm Orix (8591.T), opens new tab is teaming up with the Qatari sovereign wealth fund to launch a Japan-focused private-equity buyout fund that may total over 1 trillion yen ($6.63 billion) in size, the Nikkei daily reported on Tuesday.
Orix will hold a 60% stake and the Qatar Investment Agency a 40% stake in the newly established fund management company, the Nikkei said.
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Reporting by Anton Bridge; Editing by Christian Schmollinger
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CoreWeave needed a lot of things to go right on Monday as it released third-quarter financial results, and one of the most critical was showing that its contracted future revenues could hit a $50 billion target Wall Street had set as a benchmark for the AI data-center and infrastructure operator.
In its announcement, CoreWeave confirmed it nearly doubled its revenue backlog,which includes “remaining performance obligations” (RPOs) and other amounts it estimates will be recognized as revenue, to $55.6 billion, up from $30 billion the previous quarter. The surging backlog, which represents future revenues from customers, was driven by contracts with Meta, OpenAI, and French AI startup Poolside. Earnings and revenue, meanwhile, both beat analysts’ consensus estimates.
The company also reported an increase in the debt on its balance sheet, however, and it revised its full-year revenue guidance downward. Following its earnings release and call with analysts, the stock dropped 6% in after-hours trading.
Someinvestors have trained a gimlet eye on CoreWeave as more skeptics kick the tires of the booming AI trade and the concurrent infrastructure buildout. Concerns about CoreWeave, which some see as a potential canary-like indicator of weakness in the AI ramp-up, and about the AI build-out in general have sent the stock on a journey that has seen it tumble more than 30% from mid-August highs.
The downward revision in revenue guidance reflected delays in construction of some of CoreWeave’s data centers. “While we are experiencing relentless demand for our platform, data center developers across the industry are also enduring unprecedented pressure across supply chains,” CEO Michael Intrator said during the analysts’ call. “In our case, we are affected by temporary delays related to a third-party data-center developer who is behind schedule.”
Chief financial officer Nitin Agrawal offered full-year 2025 revenue guidance of $5.05 billion to $5.15 billion, down slightly from the guidance Intrator offered on the second-quarter earnings call, of between $5.15 billion to $5.35 billion. The customer impacted by the delay agreed to adjust the delivery schedule and extend the expiration date, Intrator said, which means CoreWeave will maintain the total value of the original contract.
Agrawal saidthe company’s 2025 capex spending would be between $12 billion to $14 billion, down significantly from the $20 billion to $23 billion Intrator forecastlast quarter. However, Agrawal said CoreWeave expects 2026 capex to soar.
“Given the significant growth in our backlog and continued insatiable demand for our cloud services, we expect capex in 2026 to be well in excess of double that of 2025,” Agrawal said.
Revenue leaps, losses narrow, debt increases
CoreWeave reported revenues of $1.4 billion for the quarter, up from $584 million in the same quarter last year and beat analysts’ estimates. Profitability, at least by traditional GAAP measures, remains elusive. CoreWeave reported a net loss of $110 million, although it was an improvement over its $359.8 million loss in the third quarter last year and also better than analysts expected.
Adjusted net loss, which shows financial performance without extraordinary items, was $41 million for the quarter compared to the same quarter last year when it was break-even, Agrawal said. Adjusted EBITDA, which shows earnings without certain one-time expenses, were $838 million in the third quarter, compared to $379 million in Q3 2024.
Operating income, a metric that shows profit from core businesses, fell to $51.9 million, compared to the same quarter last year when it was $117.1 million. Operating margins shrunk to 4% from 20%.
Meanwhile, adjusted operating income, which shows a different view on core business performance, was $217 million for the third quarter, compared to $125 million in the third quarter of 2024, said Agrawal, the CFO. CoreWeave’s third quarter adjusted operating margin was 16%, due to higher revenues, lower costs, and the timing of data center deliveries from third parties.
While Monday was just this side of positive for CoreWeave, analysts who are bearish on the AI cloud computing company remain leery of its finances. They see the company as at risk of being overwhelmed by the significant financial commitments it has taken on to build out data centers, which currently look disproportionately large compared to its revenues and cash flow. Based on its latest earnings release, CoreWeave has$9.7 billion in bills due within the next 12 months on its balance sheet, and a total of$14 billion in current and longer-termdebt. Last quarter, those figures were $7.6 billion and $11 billion, respectively.
CoreWeave also has $34 billion in scheduled lease payments on contracts that will commence between now and 2028. Interest expense reached $311 million for the quarter, nearly triple the figure from the year-earlier period, of $104 million.
CoreWeave bulls, meanwhile, remain confident that revenues from the company’s book of contracts will eventually far outstrip its debt obligations. During the past three months, CoreWeave has announced a spate of significant deals, booking a $14.2 billion deal to provide Meta with computing capacity and an agreement with Poolside for a data center with 40,000 of Nvidia’s coveted GPUs.
