Category: 3. Business

  • Study Shows Antibiotic Resistance Risk in Commonly Used Drug – PIRG

    1. Study Shows Antibiotic Resistance Risk in Commonly Used Drug  PIRG
    2. Might coccidiosis control programs lose ionophores?  WATTPoultry.com
    3. “Is Poultry Meat Harmful?” Study Raises Concern  OnlyMyHealth
    4. Ionophore use in farming drives global spread of antibiotic resistance genes, study finds  News-Medical
    5. Antibiotics used in food-animal production linked to resistance in people  CIDRAP

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  • U.S.’ FMC Opens Investigations into Foreign Flagging Practices and Global Maritime Chokepoints | NorthStandard

    The U.S. Federal Maritime Commission (FMC) has recently launched two investigations that could have implications for international shipping and U.S. trade. These actions reflect the FMC’s stated concern over regulatory practices by foreign governments and vulnerabilities in key global shipping routes which the FMC believes may be resulting in unfavourable shipping conditions in U.S. foreign trade.

    The investigations are information-gathering, and specific measures have not been proposed or threatened. Nevertheless, due to the potential importance of the investigations, they bear monitoring.

    What Is the FMC and What Does It Do?

    The FMC is the U.S. government agency responsible for regulating the international ocean transportation system for the benefit of U.S. exporters, importers, and consumers. Its mission includes ensuring a competitive and reliable international ocean transportation supply system that supports the U.S. economy and protects the public from unfair or deceptive practices.

    The FMC oversees common carriers, marine terminal operators, ocean transportation intermediaries, and carrier agreements. Amongst other activities, the FMC maintains and reviews service contracts, ensures common carrier tariffs are published, and regulates certain cruise ship bonds. Additionally, the FMC is authorized to investigate and take action when foreign laws, regulations, or business practices result in conditions that are unfavourable to U.S. shipping interests. The FMC has a range of tools at its disposal, including the ability to suspend service contracts, impose fees, restrict port access, and deny vessel clearance.

    Focus on Global Maritime Chokepoints

    An investigation announced earlier this year seeks to analyse the impact on U.S. trade of global transit constraints at maritime “chokepoints”. [1] The FMC identified seven such chokepoints: the English Channel, the Malacca Strait, the Northern Sea Passage, the Singapore Strait, the Panama Canal, the Strait of Gibraltar, and the Suez Canal. The FMC questions whether delays or restrictions at these areas (whether due to infrastructure limits, geopolitical tensions, or natural factors) have ripple effects on costs, schedules, and cargo movement into and out of the U.S.

    The FMC’s investigation aims to better understand how these chokepoints affect U.S. trade and what can be done to build resilience in the face of growing global instability and capacity constraints. The FMC will also consider whether the actions of any foreign government or other maritime interests might contribute to these delays/restrictions and constitute anticompetitive behaviour that is prejudicial to U.S. shipping interests.

    The FMC’s findings have not yet been announced. The situation is being closely monitored by maritime stakeholders.

    Investigation into Flags of Convenience

    The most recent investigation launched in May focuses on foreign flagging practices, often referred to as “flags of convenience.” The FMC is reviewing whether the laws, regulations, or behaviours of flags of convenience are creating unfair conditions for U.S.-related shipping. These concerns stem from what the FMC describes as the “’race to the bottom’ – a situation where countries compete [for flag registration] by lowering standards and easing compliance requirements to gain a potential competitive advantage.” [2] The investigation intends to assess if foreign-flagged vessels may be benefiting from looser standards, such as lower labour or safety requirements, that put U.S.-flagged or U.S.-serving carriers at a competitive disadvantage.

    The FMC is inviting comments from the public and industry stakeholders during a 90-day window through 20 August 2025, encouraging input from those directly affected.

    What This Means for the Industry

    While both investigations are still in early stages, the FMC has underscored its authority to act if it finds that foreign practices are harming U.S. interests.  Under existing U.S. law, the FMC has the power to impose measures such as limiting port calls, suspending service contracts, or directing U.S. Customs or the Coast Guard to deny entry or clearance to certain vessels in extreme cases.  Notably, the FMC has not proposed or threatened any such measures.  These investigations are informational only at this stage.

    For members and other industry stakeholders, these investigations are important to monitor. They reflect a more proactive regulatory approach that could eventually lead to changes in how certain carriers operate in U.S. trades or how disruptions at chokepoints are addressed from a policy standpoint.

    We will continue to follow developments and provide updates as the FMC’s findings emerge. In the meantime, stakeholders are encouraged to review the public notices and consider submitting comments, particularly if they have insights or experiences relevant to the issues under investigation.


    [1] The Federal Register notice announcing the investigation is available here.

    [2] A copy of the FMC’s Federal Register notice announcing the investigation is available at here.

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  • CNIL requests public comments on draft recommendations on the use of tracking pixels in emails

    CNIL requests public comments on draft recommendations on the use of tracking pixels in emails

    On June 12 2025, the French supervisory authority (CNIL) requested public comments on the draft recommendations on the use of tracking pixels in emails (Draft Recommendations). 

    Tracking pixels are an alternative tracking method to cookies, taking the form of a nearly invisible image embedded in an email or on a webpage. They let the sender know that a user has read the email or visited the page. The Draft Recommendations focus on the use of these pixels in emails, highlighting the growing number of complaints the CNIL has received in this area.

    The Draft Recommendations note that the use of tracking pixels must comply with the provisions of the GDPR and the relevant provisions of the French Data Protection Act No 78-17 of January 6 1978 (the French Data Protection Act), with the sender of the email being considered the controller, even when subcontracting the management of the trackers to third parties. The email service providers which offer the integration of tracking features into emails, including to provide reports on behalf of data controllers are considered processors.

    In accordance with Article 82 of the French Data Protection Act, the integration of tracking pixels into emails requires in principle the prior collection of consent from the recipient. The Draft Recommendations clarify that consent is required for emails intended to:

    • evaluate and improve the performance of marketing campaigns, for example by adjusting message subject lines to increase attractivity; 
    • adjust the frequency or stop sending marketing campaigns to preserve the deliverability of such campaigns;
    • personalise emails based on the recipient’s interest in the emails received, for example by personalising the content of the emails;
    • create recipient profiles based on preferences and interests already expressed; and
    • detect and analyse suspected fraud, including actions that may indicate automated behaviour.

    As an exception, consent is not required for the use of pixels that are implemented solely for user authentication, security purposes or for measuring overall email opening rates. In the latter case, it is specified that the resulting statistics must constitute anonymous data and can only concern emails requested by the user or that are related to a service requested by the user. The Draft Recommendations also note that further consent is not required where data is reused and has been anonymised. 

    The Draft Recommendations further clarify that users must be informed and that their consent must be freely given. This can be achieved by ensuring, in particular, that:

    • each purpose of processing is highlighted in a short, prominent title accompanied by a brief description; 
    • recipients are aware of the scope of their consent and the channel that will be used for tracking pixels; and
    • recipients are given the possibility to provide specific consent for each individual purpose.

    Additionally, the Draft Recommendations emphasise that users must always have the option to withdraw their consent. To meet this requirement, the CNIL recommends that a link for withdrawal be included in the footer of each email using a tracking pixel.

    Public comments on the Draft Recommendations must be submitted by July 24 2025.

    The press release is available here and the Draft Recommendations are available here. Both only available in French.

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  • China's Innogen expects to complete weight-loss drug trials next year – Reuters

    1. China’s Innogen expects to complete weight-loss drug trials next year  Reuters
    2. Novel GLP-1 Agonist Promotes Safe and Effective Weight Loss  Medscape
    3. Chinese Biotech Showcases Challenger to Eli Lilly’s Obesity Drug  Bloomberg
    4. Data from the Phase 2 Clinical Trial of CX11/VCT220 in China Presented at ADA 2025  GlobeNewswire
    5. ADA: Ecnoglutide Yields Superior, Sustained Reduction in Body Weight  Endocrinology Advisor

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  • Building coalitions for climate transition and nature restoration

    Building coalitions for climate transition and nature restoration

    Executive summary

    Global climate and biodiversity outcomes will largely be determined in emerging and developing economies (EMDEs). We propose a four-pillar strategy to support climate and nature preservation in line with the economic interests of both developing and advanced countries. This would move beyond voluntary pledges to embed climate and nature objectives into the structures of trade, finance and industrial policy, creating a self-reinforcing system of cooperation and reducing the net costs of the green transition.

    Under Pillar 1, a coalition of advanced and developing countries would link tiered carbon pricing with a common carbon border adjustment mechanism (CBAM). Pillar 2 would create a climate-finance coalition to decarbonise the power sectors of developing countries. Pillar 3 would involve partnerships to develop clean energy-intensive industrial production stages in developing economies with rich renewables endowments; these would feed into the supply chains of the European Union and other energy-importing advanced economies. Pillar 4 would redesign markets to create scalable and credible mechanisms to fund carbon removals. Technology-based removals can be incentivised through the introduction of clean-up certificates into the EU emissions trading system, while nature-based removals would require improved market design centred on a new asset class: nature shares.

    The four pillars reinforce each other. A multi-country CBAM and carbon pricing coalition (Pillar 1) would reduce the cost of financing power sector decarbonisation (Pillar 2). Linking EMDE membership of the CBAM and carbon-pricing coalition to financial support for the decarbonisation of power sectors would also make it more attractive for EMDEs to adopt carbon prices. Decarbonisation of power sectors (Pillar 2) would be a precondition for developing clean, highly energy-intensive industry in renewables-rich EMDEs (Pillar 3).

    The Pillar 1 coalition should include the EU, China and as many other countries as possible. Advanced countries and China could underpin the Pillar 2 financier coalition. Pillar 3 would involve the EU and potentially other energy-poor advanced countries, along with EMDEs that are richly endowed with renewables. Pillar 4 would include the main custodians of the planet’s natural capital. Enabling these coalitions will require EU leadership.

    This Policy Brief distils some of the main messages of the Paris Report 2025, a joint initiative by Bruegel and CEPR (Pisani-Ferry et al, 2025). This year’s focus is on accelerating the energy transition and restoring nature in emerging and developing economies. We thank all Paris Report contributors, and Patrick Bolton, Kim Clausing, Ignacio Garcia Bercero, Heather Grabbe, Alissa Kleinnijenhuis, Matthias Kalkuhl, José Scheinkman and Simone Tagliapietra for comments on an earlier draft.

     

    1 Introduction

    The planet’s future depends increasingly on emerging and developing economies. Advanced economies continue to matter because of their higher per-capita emissions, their shares of global trade and finance, and their influence through research, technology and diplomacy; but their share in global greenhouse gas emissions is shrinking. Success in stopping global warming and halting biodiversity loss hinges on whether countries such as India, Indonesia, Brazil and South Africa adopt low-carbon, nature-positive development paths, and if they do so quickly. The same applies to China, which is both the world’s top emitter of CO2 and the country at the forefront of the green industrial revolution.

    Geopolitical fragmentation, shifting priorities and a hostile United States administration are slowing the transition to a more sustainable economic model in line with the landmark Paris Climate Agreement of 2015. With climate and nature degradation accelerating, governments that understand the importance of climate and nature actions – still in the majority – are faced with hard questions. Recent international discussions on climate change mitigation and the preservation of biodiversity have centred on ambitious targets and the closing of funding gaps. These remain important topics for negotiation but are no longer sufficient. Instead, a broader approach is required to connect mitigation with adaptation and the preservation of nature.

    This calls for deeper cooperation among countries with common interests in trade, clean energy and nature. Recognising that this group will for now not include the US, we propose coalitions of the willing for climate, biodiversity, trade and finance – wherever mutual interests can still align.

    The European Union will need to play a special role in the creation of these coalitions. Because of its strong consensus around climate science, an ambitious decarbonisation agenda and a functioning, expanding emissions trading system that has delivered high carbon prices, it has both the credibility and the responsibility to lead, engaging emerging markets and developing economies (EMDEs) and building financing alliances with other advanced countries.

     

    2 The case for action

    In a darkening geopolitical landscape, the pace of technological innovation is a bright spot. Renewable energy and other green technologies have rapidly gained cost competitiveness and scale. Most new renewable power is now cheaper than fossil fuel alternatives. The IEA (2024), IRENA (2024) and Lazard (2024), among others, have shown that the levelised cost of electricity (LCOE) of unsubsidised solar and wind is often lower than that of fossil fuel-based electricity generation, especially when considering new power plant construction.

    Solar photovoltaic (PV) costs have plummeted to roughly $0.04 per kWh, making solar power more than 50 percent cheaper than generation from fossil fuels or nuclear plants (IRENA, 2024). Even accounting for network and backup costs, this is major progress that is bound to affect the energy pecking order. This dramatic cost decline, alongside improvements in wind turbines and battery technology, means clean technologies offer better economic returns than coal or gas. In dollar terms, investment in renewables now outpaces fossil electricity investment by ten to one, with more investment in solar than in all other power sources combined. Year-on-year global growth in electricity generation from solar PV was double the growth from all fossil fuels combined in 2024. Other green technologies are also scaling quickly. Meanwhile, electric vehicle sales have risen from 3 million units in 2020 to 17 million units in 2024 (IEA, 2025).

    But despite these developments, investment in new coal-fired power plants continues, particularly in China, which approved 106 gigawatts of new coal power capacity in 2022 alone – four times the amount approved in 2021. Reasons for this include concerns about supply security, local support for coal and the high upfront cost of investment in renewables that many countries find difficult to finance. Unless retired early, these coal plants will remain in operation for decades, locking in emissions far beyond 2030. Meanwhile, the global vehicle fleet remains overwhelmingly dependent on fossil fuels: in 2024, more than 95 percent of vehicles in circulation still had internal combustion engines.

    Consequently, climate policies and trajectories are far off the path needed to reach emissions targets compatible with the Paris Agreement’s objective of limiting global warming to 1.5 degrees Celsius above pre-industrial levels. Continuing with today’s policies is projected to lead to about 2.7°C of warming by 2100. Moreover, aggregate projections mask stark differences between advanced and developing economies. Emissions in most advanced economies have already peaked and steady declines have begun. In contrast, emissions in many EMDEs are still rising, driven by economic and population growth and continued heavy reliance on coal, oil and gas.

    Figure 1: Historical emissions, 1970-2023, and requirements for reaching net zero in 2050

    Source: Grabbe et al (2025). Note: several countries, including China and India, have set less ambitious targets. * EMDEs includes China. The 2050 projection is given for EMDEs as a whole and not separately for China. BAU = business as usual; NDC = Nationally Determined Contribution; LULUCF = land use, land-use change and forestry.

    As of 2023, EMDEs (including China) accounted for roughly two-thirds of global emissions. Their share is expected to grow further as they contribute the bulk of new emissions. Advanced economies account for a shrinking portion of annual emissions (for example, the EU and United Kingdom together now contribute only about 8 percent of global emissions). Reaching global net zero emissions by 2050 requires a sharp break with the current emissions trend in EMDEs (Figure 1). Limiting global warming to 1.5°C would require an even more radical break, consistent with reaching global net-zero emissions by the mid-to-late 2030s rather than 2050.

    EMDEs are also custodians of much of the planet’s natural capital, so that collective climate outcomes are intertwined with how those countries manage nature and biodiversity. Many of the world’s critical carbon sinks and biodiversity hotspots (including tropical forests and wetlands) are located in developing regions across Latin America, Africa and Asia. These ecosystems bolster climate resilience by absorbing CO₂ and providing a buffer against extreme weather. Conversely, their destruction would accelerate climate change and undermine adaptation efforts. Nature-based solutions, such as reforestation and ecosystem restoration, could provide 20 percent to 30 percent of the emissions reductions needed to limit warming to 1.5°C (chapter 7 in IPCC, 2022). However, continued deforestation or ecosystem collapse (for instance, of the Amazon rainforest) would release vast amounts of carbon and destabilise regional climates. Climate change and biodiversity loss are mutually reinforcing: climate change is now a leading driver of biodiversity loss, and in turn the erosion of biodiversity undermines natural carbon sinks and ecosystem resilience. It follows that preserving nature – alongside cutting emissions – is essential for climate stability and nature sustainability.

    The costs of the green transition and of restoring/protecting nature in emerging economies are often disproportionately high relative to their GDPs and fiscal capacities. Our best guess estimates of the investments needed are far above current investment levels in EMDEs (excluding China). In practice, annual clean-energy investment in developing regions would need to more than quadruple from 2022 levels by 2030. This would be unprecedented. It reflects the reality that many EMDE economies are both carbon-intensive (hence requiring more investment to decarbonise) and growing rapidly (hence needing more energy infrastructure overall).

    Financing these investments is challenging because of the high cost of capital in EMDEs. Capital for clean energy projects is considerably more expensive in developing markets, reflecting higher macroeconomic risks, regulatory and political uncertainty, and less developed financial systems (Berglof et al, 2025; Fornaro et al, 2025; Sen, 2025). For example, in 2021 the real cost of capital for a utility-scale solar PV project was about 3 percent in Europe and the US, but roughly 7 percent in India and Mexico, over 9 percent in Brazil and as high as 10 percent to 15 percent in sub-Saharan African countries (IEA, 2023). This steep disparity in financing costs greatly inflates the levelised cost of renewable energy in emerging economies, often offsetting their natural advantages, such as abundant solar irradiation.

    International climate finance is supposed to help bridge this gap, but it remains insufficient. Support has fallen short against lofty pledges. In late 2024, advanced countries agreed in principle (the ‘Baku commitment’) to provide about $300 billion per year in climate finance for developing nations, but the flows in 2022 were around $100 billion. The gaps in nature conservation are equally mind-boggling. To reverse biodiversity decline, the Kunming-Montreal Global Biodiversity Framework (2025) calls for a financing gap of about $700 billion per year to be closed. Of this, $500 billion per year should come from phasing out harmful subsidies, reflecting the fact that, at present, nature conservation spending is vastly overshadowed by expenditures that harm nature.

    One of the main problems with the widely cited finance gap estimates is that they are rarely accompanied by credible strategies to close them. Instead, these figures are often presented as arguments to mobilise funding, particularly from the private sector or through blended finance mechanisms. However, as the disparity between estimated needs and actual flows increases, the effectiveness of gap estimates as mobilisation tools diminishes. Rather than galvanising action, they risk fostering resignation – or worse, a new form of denial, whereby the evidence from climate science may no longer be questioned but the policies needed to combat climate change will. In wealthier countries, particularly those in temperate climate zones, this can lead to a quiet acceptance of failure and a shift in focus to adaptation, the implicit message being that the battle has been lost.

    In addition, global collective action to combat climate change faces several new problems:

    • A disjointed approach to address highly connected issues: although the containment of global warming and the preservation of nature are linked in multiple ways, they are mostly tackled separately.
    • The fraying of multilateralism: the previous remedy to the shortcomings of a disjointed approach would have been to embrace a more holistic strategy, yet nationalism and geo-political tensions hamper the search for encompassing solutions.
    • A lack of adequate incentives: developing countries (for their mitigation efforts) and advanced countries (for their contributions to the financing of these efforts) both face collective action problems, but incentives are not adequately aligned.

    To address these problems, a robust and realistic architecture is needed. In the current geopolitical context, such an architecture must be flexible, recognising that a requirement for agreement by consensus will hold the transition back and will give too much say to those that are dragging their feet. Coalitions of countries that are ready to move more quickly offer the best way forward, and are more likely to align incentives. We propose a redesign based on four pillars:

    3 A four-pillar strategy

    3.1 Pillar 1: a plurilateral carbon pricing coalition with a common CBAM

    The 2015 Paris Agreement achieved near-universal participation, with 196 countries agreeing to commit to climate action. This broad involvement was unprecedented, particularly compared to earlier agreements such as the Kyoto Protocol, in which not all developed nations participated (Guérin and Tubiana, 2025). Unlike previous top-down approaches, Paris allowed countries to determine their own climate commitments, making it politically feasible for many countries to join and offer pledges according to their capabilities. EMDEs could present both unconditional and conditional targets, explicitly linking goals to financial support from rich countries. Subsequent climate summits have also introduced systematic transparency measures, requiring regular progress reports on emissions reductions, with peer review and pressure.

    Ten years on, the Paris Agreement pledges formulated by countries (their Nationally Determined Contributions, or NDCs) make it possible to assess if they add up to the level of effort required to halt global warming (they do not). However, there is no binding enforcement mechanism to ensure that countries meet their commitments. The Paris Agreement cannot adequately address the free-rider problem associated with emissions: the benefits of emissions reductions are global, but the costs are borne by each country.

    The second withdrawal of the United States from the Paris Agreement, in January 2025 at the direction of the re-elected President Trump, was a significant setback. But it is also a strategic opportunity for other nations to strengthen international climate cooperation. The absence of the US from global climate negotiations could enable the European Union and other major global economies such as China, Brazil and India to agree ambitious and coherent international climate strategies, without needing to accommodate constraints created by US domestic politics and preferences. At the same time, it is important that any agreement should be open to future US participation.

    Scaling-up effective climate action requires a stronger link between climate policies and trade. We propose, building on Clausing et al (2025), that international collaboration take the form of an open and inclusive ‘climate coalition’. Membership obligations would include:

    1. Adoption of a tiered carbon pricing mechanism; and

    2. Adoption of a common carbon border adjustment mechanism (and no carbon border adjustment within the coalition).

    The EU decision to introduce a carbon border adjustment mechanism (CBAM) would be an incentive for countries to join the club of climate-ambitious countries. They would gain CBAM exemption, along with possible additional incentives involving technology transfer, climate finance, technical assistance, and clean energy trade liberalisation. Club members would commit to enforce domestic carbon pricing through taxation or equivalent emissions trading systems. They would also adopt CBAMs that impose tariffs equivalent to their domestic carbon prices on imports from non-member nations. This would reduce carbon leakage and maintain competitive fairness.

    Importantly, Clausing et al (2025) propose that participation be structured through a tiered carbon pricing system, such as that proposed by the International Monetary Fund (Parry et al, 2021). For example, lower-income countries could implement lower carbon price floors (eg €25 per tonne), middle-income countries would be requested to adopt a higher, but still moderate level (eg €50 per tonne) and higher-income economies would have higher rates (at least €75 per tonne), with prices adjusted regularly for inflation. Other variations, including differentiation between lower and upper middle-income countries, could also be considered.

    This differentiated approach aligns with the principle of common but differentiated responsibilities, a cornerstone of previous global climate agreements, and addresses equity concerns by mitigating potential economic impacts on developing nations. The differentiated schedule should serve as a transitional measure, with carbon tax rates increasing as countries achieve higher levels of income. This expectation of carbon price convergence should reduce incentives for carbon-intensive industries to relocate to jurisdictions with lower carbon prices. Both the levels of the tiers and the pace of convergence would be subject to negotiation (Clausing et al, 2025).

    The coalition would initially focus on the carbon-intensive goods included in the EU CBAM: aluminium, iron and steel, cement, fertilisers and hydrogen production. These industries comprise a significant share of global carbon emissions (about 20 percent), including both direct emissions and the emissions from the electricity used in their production. But the CBAM could be enlarged if similar measures are adopted by other countries, for example in East Asia, and be broadened if other goods end up being added to the intermediate products of the initial list.

    The size and economic value of the market created by the club will determine the incentives to join. The economic value would determine the club’s ability to internalise the climate benefits of collective mitigation efforts.

    This proposed climate club would complement the United Nations Framework Convention on Climate Change Conference of the Parties (COP) process by deepening collaboration among coalition members – primarily because it relies on reciprocity and meaningful incentives rather than voluntary commitments and peer pressure. Countries would gain economic benefits from participation and the reciprocal structure would incentivise sustained participation and climate action, while addressing carbon leakage and competitiveness concerns.

    A viable coalition should quickly expand from the EU and its main suppliers to other large countries, including China, Korea, Japan, India, South Africa and Brazil. These countries are, of course, at very different stages of development, and their respective incentives will need to be calibrated carefully. In addition to a tiered schedule for carbon pricing, the design should include commitments to technology transfer and financial support for green transitions in lower-income countries. In light of concerns about industrial overcapacity in sectors such as steel, it may also require an agreement to limit or eliminate subsidies. The EU would need to play a leading role in establishing this framework.

    3.2 Pillar 2: Scaled-up climate finance conditional on effective decarbonisation commitments

    The current commitments of advanced countries to finance EMDE decarbonisation are insufficient and are not matched by developing country commitments to decarbonise. Therefore, the implicit contract between North and South can (and in many instances does) result in an unproductive exchange of false promises: advanced countries pretend they will finance decarbonisation in the South, while developing countries pretend that they will decarbonise.

    A way out of this conundrum would be to form ‘climate finance coalitions’ involving subsets of advanced countries willing to fund decarbonisation in the South and subsets of developing countries willing to decarbonise their economies if given access to funding on reasonable terms (Bolton and Kleinnijenhuis, 2025). This mutual commitment would be in the self-interest of all participating countries: all would gain from the avoidance of physical, health and economic damage thanks to lower emissions in EMDEs, while economic benefits would be roughly in proportion to countries’ GDP. As a result, fiscal support for the decarbonisation of EMDEs (except China) would be in the economic interest of advanced countries and China, even if EMDEs do not contribute (Bolton and Kleinnijenhuis, 2025).

    The cost of funding developing country decarbonisation as a share of the GDP of the financier coalition would depend on the size of that coalition. A coalition of all advanced countries and China would pay less than 0.2 percent of GDP annually for EMDE power-sector decarbonisation consistent with the Paris 1.5°C objective. For a funding coalition that excludes the US but includes China, the EU, Canada, Japan, South Korea and some additional smaller industrial partners, the fiscal burden would be about 0.2 percent of GDP. If China is also excluded from the financier coalition, the cost would rise to 0.3 percent of GDP/year.

    The greater the economic damage from climate change, the smaller the critical mass of participants would need to be for coalition financing to be profitable. But even if global economic damage (the social cost of carbon) were relatively low ($190/tCO2, as assumed by Rennert et al, 2022), a financier coalition consisting of the EU and advanced countries except the US would benefit economically from financing the decarbonisation of most of the largest developing country power-sector emitters. If the US or China were to join, the coalition would find it in its interest to finance the decarbonisation of almost all developing country emitters. If the assumed damages are significantly higher, as argued by Bilal and Känzig (2025), large entities including the EU, China (and the US) would find it profitable to embark on decarbonisation support alone, even if not joined by other partners.

    Under the Paris Agreement, all signatories must offer new NDCs at COP30 in Brazil in November 2025. With the next versions not due until 2030, this set of NDCs represents the last chance to put emissions on a net-zero consistent path. The EU and its climate finance coalition partners should offer conditional fiscal support to all developing countries (except China and oil and gas producers) that are willing to commit to net-zero consistent decarbonisation of their power sectors. While only accounting for about 40 percent of developing countries’ emissions, power-sector decarbonisation is a necessary step for the decarbonisation of industry and transport.

    3.3 Pillar 3: Green industrial partnerships between the EU and developing countries

    Europe currently imports most of its oil and gas at relatively high cost. The continent’s transition to clean energy will end its dependency on imported fossil fuels, but not its relative energy scarcity (McWilliams et al, 2025). Europe is not well-endowed in green energy. Limited land availability and a relatively poor solar potential (except in Southern Europe) imply that the cost of producing electricity will be higher than in countries on the other side of the Mediterranean, in the Middle East or in Africa. Nuclear power can help, but not to the point of eliminating Europe’s structural cost disadvantage, as nuclear is relatively expensive compared to renewables once the possibility of electricity storage is factored in.

    As a result, Europe will remain an energy importer in the medium and possibly long terms. However, transporting electricity is much more costly than transporting fossil fuels, even taking into account the possibility of producing hydrogen and transporting it by sea or through pipelines. In contrast, energy-intensive intermediate products in the value chains of the chemical and steel industries, such as ammonia, fertilisers, methanol and reduced iron, can be easily and cost-effectively transported by sea.

    For this reason, the green transition is bound to transform the international division of labour along value chains. Developing country exporters of primary products such as iron ore are likely to move down the value chain and export processed products, such as direct reduced iron, instead of raw commodities. Consequently, some upstream segments of European energy-intensive industries (EIIs) would move South. This restructuring of global value chains would be economically efficient and would help the industrialisation of the South.

    To the extent that energy-intensive intermediate inputs, such as ammonia or direct reduced iron, are produced with green electricity or green hydrogen, it would also lead to significant greenhouse gases emission reductions.

    This leaves two important questions unanswered: 

    1. How to ensure that the migration of energy-intensive production supports Europe’s own green industrialisation goals and, more broadly, its efforts to improve its competitiveness and its economic security; and
    2. How to ensure that it results in global emissions reductions, rather than simply carbon leakage from the EU to the Global South.

    McWilliams et al (2025) seek to answer both questions. On the first, they argue that the direct value added and employment loss of the relocation of energy-intensive intermediate products to the South would be modest. In Germany, EIIs account for most industrial energy demand but only 5 percent of manufacturing wages and 6 percent of the value added. The upstream segments of those industries represent a fraction of those numbers. At the same time, relocating these production stages should not only boost the competitiveness of downstream EII segments, but also industrial competitiveness more broadly, by reducing energy costs. Substituting domestic production of ammonia, methanol and reduced iron by imports could reduce EU electricity demand by around one-quarter of today’s green electricity production in the EU, and around one-tenth of 2050 projected demand (McWilliams et al, 2025). The ensuing impact on EU energy prices would benefit industrial consumers, households and the public purse.

    The policy implications are two-fold.

    First, while subsidies to modernise and protect European heavy industry can be justified both by the green transition and by the need to retain potentially competitive industry in a context of possible Chinese overcapacity, public money should both be conditional on abatement efforts and go to less-energy-intensive downstream industries, rather than highly energy-intensive intermediate products. This requires a revamping of the EU Clean Industrial Deal, which does not presently discriminate between production stages that should remain in the EU in the long term and those that need not.

    Second, EU industrial policy must be linked to trade, investment and climate policies that embed low-cost energy intensive production in developing countries into EU value chains. The two pillars of EU climate policy discussed above – an EU-led carbon pricing and CBAM coalition, and an EU-led coalition to fund decarbonisation of power sectors in developing countries – are critical in this regard. In addition, Clean Trade and Investment Partnerships, as announced by the European Commission (Jütten, 2025), would need to be set up to both improve market access to the EU and transfer technology to those developing countries that have the potential to be reliable suppliers of green-energy-intensive intermediate products.

    Conceptually, the same reasoning could apply to the decarbonisation of other advanced countries. We have presented it for Europe because it is where the policy question arises.

    3.4 Pillar 4: Effective markets for carbon removal and nature restoration

    It is almost certain that the world will overshoot climate targets. This makes investment in negative emissions essential. Limiting global warming to below 1.5°C does not rely only on the containment of emissions, but also on large-scale deployment of carbon dioxide removal (CDR) technologies of all kinds. Some models project gross CDR volumes of 10 to 20 GtCO₂ per year by the second half of the twenty-first century, equivalent to one-quarter to one-half of today’s global emissions (Hoegh-Guldberg et al, 2018).

    Negative emissions can be achieved through natural sequestration, which relies on photosynthesis and ecosystem processes (eg afforestation, soil carbon, carbon stored in coastal and marine ecosystems), and technological solutions that extract CO₂ from the atmosphere, such as direct air capture and storage (DACS), which does not yet exist at scale.

    This pillar proposes two market innovations:

    1. A market mechanism for negative emissions: integrating clean-up certificates into com- pliance markets (starting with the EU emissions trading system, ETS) for carbon removals that are reliably permanent; and
    2. Credible markets for long-term nature-based carbon capture that also value the broader ecosystem services and co-benefits of nature restoration – not just the carbon.

    The goal is to prepare for a future in which net-negative emissions will be necessary in the second half of the century, to compensate for temperature overshoot and restore a safer climate trajectory.

    3.4.1 A market mechanism for negative emissions: clean-up certificates

    Following Edenhofer et al (2025), we propose a new market-based instrument in the form of clean-up certificates, designed to embed CDR into the EU ETS and make the financing of net-negative emissions feasible at scale. The certificates would offer firms a legal right to emit beyond their allowances today, in exchange for an obligation to remove the equivalent amount of CO₂ from the atmosphere in the future. This creates a form of carbon debt, explicitly linked to future removals.

    The EU ETS is approaching a structural turning point. Under current rules, the last allowances for energy and industrial sectors will be auctioned around 2039. Yet some residual emissions – particularly in hard-to-abate sectors such as cement – will remain too costly or infeasible to eliminate. Without a mechanism to offset these emissions, carbon prices could spike in the 2040s, undermining the predictability and effectiveness of the EU ETS. Moreover, firms are already making forward-looking investment decisions and are banking certificates. Introducing clean-up certificates now would enable regulated entities to anticipate future compliance costs, while generating demand and finance for removals today.

    The institutional redesign would involve two steps:

    1. Issuance of clean-up certificates: these certificates would authorise emissions today but create a carbon debt obligation to remove the equivalent CO₂ in the future.
    2. Creation of a European Carbon Central Bank (ECCB), which would oversee the issuance, verification and enforcement of carbon debt contracts. It would act as a regulatory and financial anchor, ensuring transparency, risk management and intertemporal consistency in carbon markets.

    Clean-up certificates introduce intertemporal flexibility into emissions trading – analo- gous to allowing not just banking but also borrowing. Firms can emit now and remove later if they expect future innovations to lower CDR costs. However, if they are pessimistic about future CDR potential, they will avoid incurring carbon debt and prefer immediate abatement.

    Time-inconsistency is obviously a major concern. Without safeguards, firms might bet on an excessively high pace of technological progress, become overindebted and end up defaulting on their carbon debt. To prevent such outcomes, Edenhofer et al (2025) propose to grant the European Commission the option of intervening in the market by limiting the amount of clean-up certificates. In addition, reducing the issuance of conventional allowances would increase overall ambition levels as a result of the overall cost reductions from introducing clean-up certificates. To insure against corporate bankruptcy, Edenhofer et al (2025) propose that firms issuing carbon debt post collateral in the form of security deposits at the ECCB. If the firm delivers the expected certified removals, the deposit is released. If it defaults, the ECCB retains the funds and uses them to procure equivalent removals elsewhere.

    The EU ETS should thus evolve from a pure mitigation instrument into a tool that manages the entire carbon cycle. Over the longer run, negative emissions from nature-based removals could be integrated, potentially as a separate category of clean-up certificate. The potential for such removals is particularly high in EMDEs and in low-income countries, which also host significant biodiversity. However, two conditions must be met: nature-based removals must be additional and permanent. Achieving this requires a fundamental redesign of nature markets, which we address next.

    3.4.2 A market for natural provision of negative emissions and nature restoration 

    Cantillon et al (2025) propose a novel design for nature markets to scale up carbon removals and nature restoration in the Global South. The aim would be to overcome the high transaction costs, low credibility and short-termism that characterise the current voluntary carbon markets. The proposed mechanism would address these design flaws through four innovations:

    1. Jurisdictional scale: projects would be defined at regional or provincial level rather than small-scale private projects. This scale would reduce leakage, improve monitoring and enhance additionality by aligning with regulatory boundaries. Jurisdictions would compete to attract capital.
    2. Equity-based instruments: instead of issuing credits, jurisdictions would sell shares in a portfolio of nature-based projects. These shares would entitle holders to receive ‘dividends’ in the form of measured carbon and biodiversity benefits (eg a quantity of avoided CO₂, increase in biodiversity). Dividends would be released prudently over time, with buffers to account for ecological risk. This would allow for permanent claims without assuming permanence in ecological systems.
    3. Primary market as a crowdfunding mechanism: jurisdictions would list projects with detailed descriptions and minimum funding thresholds. Investors would allocate capital across proposals. Prices would form endogenously, with projects that attract excess demand seeing rising share prices, while underfunded projects would be delisted. This competitive mechanism would incentivise jurisdictions to improve project quality and additionality.
    4. Public market governance: to ensure integrity and reduce fragmentation, the market infrastructure – project vetting, registry management – would be publicly governed. This structure should reduce certification costs and resolve conflicts of interest inherent in today’s privately run systems.

    The proposed share-based model would address the main shortcomings of credit markets by realigning incentives and embedding long-term commitment. Unlike credit buyers, shareholders would internalise ecological risk, fostering better stewardship and accounting for the impermanence of natural systems. Jurisdictional project scope and competitive pricing would enhance additionality and minimise leakage. By pricing a bundle of project attributes, the model would generate implicit values for biodiversity alongside carbon. Centralised governance and larger project scale would reduce transaction costs, while the secondary market would ensure liquidity. Overall, the approach should shift the market from transactional offsetting to long-term ecological investment.

    To scale up, the market would require reliable demand. Rather than relying solely on offsets, a boost to demand could come from mandating institutional investors to align the carbon footprints of their portfolios with the Paris-aligned trajectories (and to do the same with their biodiversity footprints when such standards are established) and authorise them to use nature shares (on top of any other asset reshuffling) to meet this goal. A major advantage of acting at the level of funds, rather than the underlying companies, is that it would not release these companies from any existing or upcoming obligations to decarbonise and reduce their biodiversity impacts.

    While the model is well suited for provision projects, conservation is harder to finance because it delivers no flow of carbon and no added biodiversity dividends. The benefits of conservation are in the preservation of stocks of carbon and biodiversity. Cantillon et al (2025) discuss different ways to address this: 1) conservation projects could be integrated into the mechanism, which would facilitate private funding but complicate the design, or 2) it would require a separate funding mechanism, as proposed for the Amazon (see Box 1). In addition, nature-harming subsidies should be eliminated.

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  • German court suspends diesel scandal trial of former Volkswagen CEO Winterkorn

    German court suspends diesel scandal trial of former Volkswagen CEO Winterkorn

    A German court has suspended proceedings in the trial of former Volkswagen CEO Martin Winterkorn, who has been charged with fraud and market manipulation in connection with Volkswagen’s use of rigged software that let millions of diesel-engine cars che…

    FRANKFURT, Germany — A German court has suspended proceedings in the trial of former Volkswagen CEO Martin Winterkorn, who has been charged with fraud and market manipulation in connection with Volkswagen’s use of rigged software that let millions of diesel-engine cars cheat on emissions tests.

    The regional court in Braunschweig on Tuesday cited an unspecified health issue that meant Winterkorn, 78, was not in a condition to face trial.

    The court said in a statement that it had “provisionally terminated” the proceedings. It said the health issue represented a “temporary impediment” and would continue to be reviewed with the help of an expert so that proceedings could resume if Winterkorn recovers.

    Winterkorn went on trial in September, 2024 but the proceedings were suspended a few days later after Winterkorn had an accident.

    Germany’s code of criminal procedure allows for a court to provisionally terminate proceedings “if the absence of the indicted accused or some other personal impediment prevents the main hearing being held for a considerable time.”

    Prosecutors say Winterkorn knew about the illegal software well before the U.S. Environmental Protection Agency announced its discovery of the violation in September 2015. He resigned days later. He has said he learned about the practice only shortly before the announcement and earlier testified during civil proceedings that the allegations against him “are not correct.”

    In May, four former Volkswagen managers were convicted of fraud and two of them given prison sentences for their part in the manipulation of emissions controls.

    The former head of diesel development was sentenced to four and a half years in prison, and the head of drive train electronics to two years and seven months by the court in Braunschweig. Two others received suspended sentences of 15 months and 10 months.

    The company has paid more than $33 billion in fines and compensation to vehicle owners. Two VW managers received prison sentences in the U.S. The former head of the company’s Audi division, Rupert Stadler, was given a suspended sentence of 21 months and a fine of 1.1 million euros ($1.25 million). The sentence is still subject to appeal.

    .

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  • Featured news and headlines | KU News

    Featured news and headlines | KU News

    LAWRENCE — Around $1 billion gets paid by victims of ransomware attacks each year. But is payment the right strategy?

    “In the short run, paying the ransom is often the easiest way out. Yet by paying the ransom, you are encouraging hackers to come back, not just for you but for everyone else,” said Debabrata Dey, the Davis Area Director of Analytics, Information, and Operations and the Ronald G. Harper Professor of Artificial Intelligence and Information Systems at the University of Kansas.

    His new paper, titled “‘Extortionality’ in Ransomware Attacks: A Microeconomic Study of Extortion and Externality,” examines when organizations accede to ransom demands and, in doing so, incentivize attackers to launch more attacks, elevating the chance of a future breach not just for themselves but for others. The paper also weighs whether policymakers should get involved, either through punitive measures to prevent payment or tax/subsidies to compensate payment.

    The study appears in Information Systems Research.

    Dey and co-writer Atanu Lahiri of the University of Texas at Dallas created a model to illustrate the effect of how firms may react to ransom demands and provide a framework for comparing different policy interventions and strategies. The researchers additionally introduced the term “extortionality,” which they define as “extortion due to externality.”

    “If you look at the economy — and specifically at the cyber economy — ransomware attacks are more important at an organizational level than at an individual level. Hackers are more interested in organizations because they can get a lot more money for every success,” Dey said.

    Thus, the impact of externalities is also magnified.

    “Externalities are like pollution, for example. If I have a paper factory, and I am polluting the effluent stream that then pollutes a river, that’s an externality. Because through my action, I’m imposing a cost on the society. I’m imposing a cost on the fishermen down the stream without having to pay for it,” he said.

    In the case of ransomware (defined as malicious software designed to block access to a computer system until a sum of money is paid), the externality is tied to payment. If a company pays, it encourages other hackers who may be emboldened to attack more companies. Or worse, hackers may attack a critical institution such as a power plant. If ransom is not paid, the electricity of a city goes dark, thus creating chaos in society itself.

    So if Dey were a CEO of a corporation that was the target of ransomware, how would he use this research to develop a strategy to combat it?

    “I would first do a full-fledged analysis of the company’s situation: How bad is the attack, what resources are getting compromised, what services are going to be hampered and for how long, how many people are going to be touched through this process, how many users, how many consumers? Those are all considerations the CEO must figure out,” he said.

    But equally important is for an organization to prepare ways to avoid such a breach. Dey cites two types of avoidance mechanisms: protective and backup. Protective involves investing in technology as well as in education of users. Oftentimes, a breach occurs because an employee gets a phishing email and unknowingly clicks on it.

    “Backup and recovery systems are also very important because irrespective of what you do, there will be situations where you get breached. You can be 100% cautious, but there is no fail-safe system,” he said. 

    “If your backup and recovery system is good, then as a CEO, you’ll say, ‘OK, let’s do a quick analysis of the damage that we are going to go through, what kind of recovery we can have, how long will it take for us to come back to the original state?’ And if that cost is not very large, then you might decide not to pay the ransom.”

    Dey first became interested in this topic almost a decade ago when a massive ransomware attack breached computers in over 100 countries worldwide. 

    “I have a relative who’s a doctor in a hospital in India, and we were talking about how their hospital reacted to the breach. That’s when my interest really started growing. Then suddenly, you see all these ransomware attacks in the U.S. The DCH Health System based in Alabama was breached, and three DCH hospitals were impacted. Then a meat processing farm. Then a gas pipeline. There have been so many of them,” he said.

    A KU faculty member since 2022, Dey specializes in artificial intelligence and information systems. He has also recently focused on issues related to public policy. His most recent article, titled “Polarization or Bias: Take Your Click on Social Media,” appeared in the Journal of the Association for Information Systems. 

    “At the end of the day, what is the most practical solution to dealing with ransomware?” Dey asked. “The solution is investing toward these events not happening. Because once it happens, it could be a long day or a long week or even a long month.”

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  • First-Line Bemarituzumab Plus Chemo Hits OS End Point in FGFR2b+ Advanced Gastric Cancer

    First-Line Bemarituzumab Plus Chemo Hits OS End Point in FGFR2b+ Advanced Gastric Cancer

    Image Credit: ©

    Ashling Wahner & MJH Life Sciences Using AI

    The addition of bemarituzumab to mFOLFOX6 (modified oxaliplatin, leucovorin, and fluorouracil) led to a statistically significant and clinically meaningful improvement in overall survival (OS) vs placebo plus chemotherapy in patients with HER2-negative, unresectable locally advanced or metastatic gastric or gastroesophageal junction (GEJ) cancer harboring FGFR2b overexpression, meeting the primary end point of the phase 3 FORTITUDE-101 trial (NCT05052801).1

    Findings announced by Amgen also showed that the most common treatment-emergent adverse effects (AEs) reported in more than 25% of patients treated in the bemarituzumab arm comprised reduced visual acuity, punctate keratitis, anemia, neutropenia, nausea, corneal epithelium defect, and dry eye. Although instances of ocular AEs were consistent with prior phase 2 data and occurred in both treatment arms, they were reported at a higher rate frequency and severity in the phase 3 bemarituzumab group.

    Detailed data from the prespecified interim analysis will be presented at an upcoming medical meeting.

    “Most patients with gastric cancer are diagnosed at an advanced stage, with poor prognosis, low survival rates, and limited therapeutic options,” Jay Bradner, MD, executive vice president of Research and Development at Amgen, stated in a news release. “These first positive topline results of an FGFR2b-targeted monoclonal antibody from our phase 3 FORTITUDE-101 study mark a meaningful advance in the development of effective targeted therapy for gastric cancer.”

    FORTITUDE-101 Overview

    The randomized, multicenter, double-blind, placebo-controlled trial enrolled patients at least 18 years of age with histologically documented locally advanced unresectable or metastatic gastric or GEJ cancer not amenable to curative therapy.2 Patients needed to be positive for FGFR2b overexpression, defined 2+ or 3+ staining on at least 10% of tumor cells per centrally performed immunohistochemistry (IHC).

    Other key inclusion criteria included an ECOG performance status of 0 or 1; evaluable disease that could be measurable or non-measurable per RECIST 1.1 criteria; no contraindications to mFOLFOX6; and adequate organ and bone marrow function.

    Patients were excluded if they received prior treatment in the metastatic or unresectable setting; however, previous neoadjuvant, adjuvant, and perioperative therapy was permitted if completed more than 6 months prior to first dose of study treatment. Other exclusion criteria included any prior treatment with a selective FGFR inhibitor; HER2-positive disease; untreated or symptomatic central nervous system disease or brain metastases; and clinically significant cardiac disease.

    A total of 547 patients enrolled across the study at 300 sites across 37 countries.1 Patients were randomly assigned to receive bemarituzumab plus mFOLFOX6 or placebo plus mFOLFOX6.

    Along with the primary end point of OS, secondary end points included progression-free survival, objective response rate, duration of response, disease control rate, quality of life, and safety.2

    Bemarituzumab is also being investigated in the phase 3 FORTITUDE-102 study (NCT05111626), where patients with previously untreated gastric cancer are being randomly assigned to receive bemarituzumab in combination with chemotherapy and nivolumab (Opdivo) or placebo plus chemotherapy and nivolumab. Data from this study are expected to read out in the second half of 2025.1

    After the safety and tolerability of the combination of bemarituzumab, chemotherapy, and nivolumab were evaluated in the first nonrandomized part of the study, patients with locally advanced unresectable or metastatic, histologically documented gastric or GEJ adenocarcinoma are being randomly assigned between the 2 arms in the second part of the study. Notably, patients being enrolled to the randomized portion are required to have centrally confirmed FGFR2b overexpression per IHC.

    References

    1. Amgen announces positive topline phase 3 results for bemarituzumab in fibroblast growth factor receptor 2b (FGFR2b) positive first-line gastric cancer. News release. Amgen. June 30, 2025. Accessed June 30, 2025. https://www.amgen.com/newsroom/press-releases/2025/06/amgen-announces-positive-topline-phase-3-results-for-bemarituzumab-in-fibroblast-growth-factor-receptor-2b-fgfr2b-positive-firstline-gastric-cancer
    2. Bemarituzumab or placebo plus chemotherapy in gastric cancers with fibroblast growth factor receptor 2b (FGFR2b) overexpression (FORTITUDE-101). ClinicalTrials.gov. Updated February 7, 2025. Accessed June 30, 2025. https://clinicaltrials.gov/study/NCT05052801
    3. Bemarituzumab plus chemotherapy and nivolumab versus chemotherapy and nivolumab for FGFR2b overexpressed untreated advanced gastric and gastroesophageal junction cancer. (FORTITUDE-102). ClinicalTrials.gov. Updated June 12, 2025. Accessed June 30, 2025. https://clinicaltrials.gov/study/NCT05111626

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  • Weight-Loss Drug Maridebart Cafraglutide Shows Efficacy in Phase 2 Trial

    Weight-Loss Drug Maridebart Cafraglutide Shows Efficacy in Phase 2 Trial

    Patients with obesity who received maridebart cafraglutide (MariTide; Amgen), a once-monthly obesity medication, demonstrated weight loss of up to 19.9% in a phase 2 trial (NCT05669599).1 Those with obesity and type 2 diabetes showed weight loss of up to 17%.

    Maridebart cafraglutide is a long-acting peptide–antibody conjugate that combines glucagon-like peptide-1 (GLP-1) receptor agonism and glucose-dependent insulinotropic polypeptide (GIP) receptor antagonism. The 2 identical GLP-1 peptide analogs conjugated to a single monoclonal antibody antagonist to the GIP receptor result in a 21-day half-life, 3 times longer than the FDA approved longest-acting once-weekly anti-obesity medication, semaglutide. The extended half-life can potentially lead to increased access and adherence for those whose health and access to health care are disproportionately affected by socioeconomic status.2 

    The mean percent change in body weight from the obesity cohort from baseline to 52 weeks ranged from −12.3% to −16.2% to −16.2%. | Image Credit: ricka_kinamoto – stock.adobe.com

    “[Maridebart cafraglutide]’s monthly or less frequent dosing has the potential to improve adherence and long-term weight control, providing the opportunity to optimize health outcomes for people living with obesity, type 2 diabetes, and related conditions,” Jay Bradner, MD, executive vice president of Research and Development at Amgen, said in a press release.3 “[Maridebart cafraglutide] delivered strong efficacy, including sustained weight loss without a plateau in the 52-week phase 2 study and meaningful improvements in cardiometabolic risk factors, representing a defining advance for the obesity field.”

    Phase 2 of the trial tested the efficacy, adverse event profile, and safety of maridebart cafraglutide at various doses with and without escalation.1 The study enrolled 592 participants—465 in the obesity cohort and 127 in the obesity-diabetes cohort. The obesity cohort was randomly assigned in a 3:3:3:2:2:2:3 ratio to receive either 52 weeks of maridebart cafraglutide subcutaneously at 140, 280, or 420 mg every 4 weeks without dose escalation; 420 mg every 8 weeks without dose escalation; 420 mg every 4 weeks with either a 4- or 12-week dose escalation; or a placebo. Participants in the obesity-diabetes cohort were randomly assigned in a 1:1:1:1 ratio to receive maridebart cafraglutide over 52 weeks at a dosage of 140, 280, or 420 mg every 4 weeks or a placebo.

    The mean percent change in body weight from the obesity cohort from baseline to 52 weeks ranged from −12.3% to −16.2% (95% CI, −15.0 to −9.7) to −16.2% (95% CI, −18.9 to −13.5). The obesity-diabetes cohort mean percent change in body weight ranged from −8.46% (95% CI, −11.0 to −5.7) to −12.3% (95% CI, −15.3 to −9.2).

    Those in both cohorts who received maridebart cafraglutide also showed a significant difference in the percentage points of glycated hemoglobin (HbA1c) levels when analyzed using the treatment policy estimand. The obesity cohort had a mean difference of –0.32 (95% CI, –0.5 to –0.2) percentage points measuring glycated hemoglobin levels. Similarly, the obesity-diabetes cohort showed a mean difference of –1.43 (95% CI, –1.9 to –0.7) percentage points in glycated hemoglobin. When analyzed using the efficacy demand, the obesity cohort did not show a significant difference in weight loss; however, the obesity-diabetes cohort did, with –2.03 (95% CI, –2.4 to –1.6) percentage points.

    Participants in both cohorts experienced improvement in additional secondary end points, including differences in systolic and diastolic blood pressure, high-sensitivity C-reactive protein (hs-CRP), and select lipid variables. Furthermore, those receiving a dose escalation over 4 or 12 weeks did not show significant differences in primary or secondary end points when compared with those that did not receive dose escalation.

    Adverse events occurred in an average of 93.5% of participants across both cohorts. The most common adverse events (AEs) were gastrointestinal, which included mild to moderate nausea, vomiting, constipation, retching, and diarrhea. There was a lower incidence of adverse events in the groups with dose escalation and those starting at a lower dose across both cohorts.

    Of the 592 participants in the obesity cohort, 8% in the dose escalation group discontinued the trial due to GI AEs, as opposed to the 12% to 17% in the no–dose escalation groups. Similarly, 6% to 16% of participants in the obesity-diabetes cohort discontinued due to GI-related adverse events. Other predefined adverse events varied in severity, ranging from mild to moderate, and included injection-site rash, reactions, and/or urticaria.

    “These results, alongside the phase 1 pharmacokinetics low-dose initiation data, have shaped our phase 3 MARITIME program,” Bradner said.3

    References

    1. Jastreboff AM, Ryan DH, Bays HE, et al. Once-monthly maridebartcafraglutide for the treatment of obesity — a phase 2 trial. New England Journal of Medicine. Published online June 23, 2025. doi:10.1056/nejmoa2504214
    2. Eberly LA, Yang L, Essien UR, et al. Racial, ethnic, and socioeconomic inequities in glucagon-like peptide-1 receptor agonist use among patients with diabetes in the US. JAMA Health Forum. 2021;2(12): e214182. doi:10.1001/jamahealthforum.2021.4182
    3. Results from Amgen’s phase 2 obesity study of monthly maritide presented at the American Diabetes Association 85th Scientific Sessions. Amgen. June 23, 2025. Accessed June 25, 2025. https://www.amgen.com/newsroom/press-releases/2025/06/results-from-amgens-phase-2-obesity-study-of-monthly-maritide-presented-at-the-american-diabetes-association-85th-scientific-sessions

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