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Category: 8. Health
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Health news round-up: cardiovascular research special – The Pharmaceutical Journal
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This Habit May Raise the Risk of Breaking a Bone
- Skipping breakfast raised fracture risk by 18% in nearly one million adults.
- Eating dinner within two hours of bed was tied to an 8% higher fracture risk.
- Simple habits—like a morning meal and earlier dinners—may help protect bones.
Your breakfast routine—or lack of one—may have lasting consequences for your bones.
A massive new Japanese study found that skipping breakfast and eating late dinners were each linked to a higher risk of osteoporotic fractures. The findings add to growing evidence from the field of chrononutrition—which explores how the timing of meals interacts with the body’s internal clock—suggesting that when you eat may matter for long-term health, not just what you eat. For example, researchers have linked eating earlier in the day to better cholesterol levels, lower insulin resistance and less body fat, all of which support the idea of eating in line with your natural circadian rhythm.
That potential connection matters because fragile bones are already a widespread problem. Roughly 13% of U.S. adults age 50 and older have osteoporosis, a disease that weakens bones and makes them more likely to break. Another 43% in the same age group have low bone mass, often called osteopenia. Taken together, more than half of older Americans are living with reduced bone strength and a higher risk of fractures.
Lifestyle habits like exercise, alcohol use and smoking are well known to influence fracture risk. What hasn’t been studied much is whether the timing of meals makes a difference. This study is one of the first to look at how skipping breakfast or eating late dinners might influence fracture risk. The results were published in the Journal of the Endocrine Society.
How Was the Study Conducted?
Researchers analyzed health records from nearly 1 million Japanese adults who took part in routine checkups. The study followed people age 20 and older, linking their lifestyle questionnaires with medical records from a large national claims database. On average, participants were tracked for about 2.6 years.
They focused on two self-reported eating habits: skipping breakfast and having a late dinner. The team tracked 4 types of osteoporotic fractures—hip, forearm, spine and upper arm—and compared people who reported these behaviors and who did not.
What Did the Study Find?
During the study, researchers logged just over 28,000 major fractures. People who skipped breakfast more than three times a week were about 18% more likely to break a bone than those who ate it regularly. Eating dinner within two hours of bedtime more than three times a week was linked to an 8% higher fracture risk.
The study also reinforced what health professionals already know—women, people with lower body weight and older adults are more prone to fractures. It also showed that meal timing habits often traveled with other choices like smoking, drinking, getting less exercise and sleeping less. Put together, the results suggest that lifestyle plays a big role in bone health—and that something as simple as when you eat may add to the risk.
How Does This Apply to Real Life?
Meal timing alone won’t make or break your bones, but it may be worth paying attention to. Starting the day with breakfast gives you a steady supply of nutrients your bones can use. Even simple options like yogurt with fruit, eggs on whole-grain toast or a smoothie made with milk and leafy greens provide protein and calcium without much effort.
Dinner habits matter too. Leaving two to three hours between your last meal and bedtime gives your body time to digest and aligns eating with your natural rhythms. Pairing that with regular weight-bearing exercise—like light strength training—and getting enough sleep helps reinforce bone strength over time.
And if you’re concerned about protecting your bone health, try to incorporate nutrients like calcium, vitamin D, protein and healthy fats into your diet. (Canned salmon can be a great source of all four.)
Our Expert Take
This recent study in the Journal of the Endocrine Society doesn’t prove that skipping breakfast or eating late dinners directly cause fractures, but it highlights how everyday routines may add up in ways we’re only starting to understand. The foundation for bone health is still the same—nutrient-rich foods, physical activity, quality sleep and limited smoking and alcohol—but meal timing may be another piece of the prevention puzzle.
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Targeting ADAR1 in Glioblastoma Slows Tumor Growth and Reignites Immune Response – Inside Precision Medicine
- Targeting ADAR1 in Glioblastoma Slows Tumor Growth and Reignites Immune Response Inside Precision Medicine
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- Cambridge scientists reprogram brain cancer cells to stop them from spreading AOL.com
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Study suggests breast milk hormones affect babies’ sleep patterns
The composition of breast milk changes throughout the day, including hormones thought to influence babies’ wake/sleep patterns, researchers said in a new study. Photo by Adobe Stock/Pixabay.com
Busy moms might be sending their babies the wrong signal if they feed evening breast milk that was expressed in the morning, a new study suggests.
The composition of breast milk changes throughout the day, including hormones thought to influence babies’ wake/sleep patterns, researchers reported Friday in Frontiers in Nutrition.
A mother might unintentionally disturb her infant’s rest if she stores breast milk in the morning and then provides it in the afternoon or evening, researchers warned.
“Breast milk is a dynamic food: Consideration should be given to the time it is fed to the infant when expressed breast milk is used,” lead researcher Melissa Woortman said in a news release. She’s a recent doctoral graduate in nutritional sciences of Rutgers University in New Brunswick, N.J.
“The timing of these cues would be particularly critical in early life, when the infant’s internal circadian clock is still maturing,” senior investigator Maria Gloria Dominguez-Bello, a professor in biochemistry and microbiology at Rutgers, said in a news release.
Doctors consider breast milk a baby “super food” that is chock full of vitamins, minerals and compounds that help build the young immune system and feed the growing body, researchers said.
It’s widely thought to be the best source of infant nutrition, but many moms aren’t able to directly breastfeed multiple times throughout the day and night. Instead, they use a pump to express and store milk for later feedings.
For the study, researchers took 10 milliliter breast milk samples from 21 women at specific intervals on two days, roughly a month apart: 6 a.m., noon, 6 p.m. and midnight. Another 17 participants provided one day’s worth of samples taken at the same times.
Researchers analyzed the samples for levels of three hormones: melatonin, cortisol and oxytocin. Melatonin and cortisol are involved in regulation of wake/sleep cycles.
The breast milk samples also were analyzed for levels of immunoglobulin A, an antibody protein produced by the immune system, and the milk protein lactoferrin. These influence the baby’s digestive system.
Results showed that melatonin and cortisol varied over the course of a day. Melatonin peaks at midnight, while cortisol is highest in the early morning.
“We all have circadian rhythms in our blood, and in lactating mothers, these are often reflected in breast milk,” Woortman said. “Hormones like melatonin and cortisol follow these rhythms and enter milk from maternal circulation.”
The other breast milk components were mostly stable throughout the day. This might be because they aren’t as strongly influenced by signals dictating circadian rhythms, researchers said.
The results suggest that moms should try to feed their expressed milk to reflect the time when it was gathered and stored, researchers said.
“Labeling expressed milk as ‘morning,’ ‘afternoon,’ or ‘evening’ and feeding it correspondingly could help align expressing and feeding times and preserve the natural hormonal and microbial composition of the milk, as well as circadian signals,” Dominguez-Bello said.
For busy moms, that adjustment stands to be a practical one, Woortman said.
“In modern societies where it may not be feasible for mothers to stay with their infants throughout the day, aligning feeding times with the time of milk expression is a simple, practical step that maximizes the benefits of breast milk when feeding expressed milk,” she concluded.
More information
The U.S. Centers for Disease Control and Prevention has more about the benefits of breast feeding.
Copyright © 2025 HealthDay. All rights reserved.
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Prostate Cancer Cases Rising After Years of Decline, Study Finds
Share on Pinterest Prostate cancer cases have risen steadily over the past decade, a new report found. Maskot/Getty Images - Prostate cancer rates rose over the past decade, following years of decline.
- The increase is driven by advanced prostate cancer diagnoses, even in males as young as 55.
- Experts say it’s time to reevaluate recommendations for PSA screening to ensure prostate cancer is caught early.
Prostate cancer rates have risen steadily over the past decade, reversing course after years of decline.
Diagnoses of prostate cancer rose by 3% annually between 2014 and 2021, following year-over-year declines of 6.4% in the late 2000s and early 2010s, according to the
latest statistics from the American Cancer Society (ACS).Even more worrisome, the growth is driven by late-stage cancer diagnoses, the most dangerous form, in which the cancer has spread to other parts of the body. Advanced prostate cancer increased by up to 6.2% annually, with the most precipitous increase observed in males over the age of 70.
Prostate cancer is the second-leading cause of cancer-related death for men in the United States, second only to lung cancer. One in eight men will be diagnosed with prostate cancer during their lifetime. In 2025, the ACS estimates 313,780 new cases of prostate cancer and 35,770 deaths from the disease.
Declines in mortality have also slowed. Between 1993 and 2012, deaths from prostate cancer fell about 3.5% per year, before slowing to a trickle — just 0.6% per year during the following decade.
For males ages 55–59, USPTF guidelines remain a “C” score, stating that periodic screening can be considered.
“It appears that we are still experiencing some of the detrimental effects of the USPSTF recommendations against PSA screening, as we continue to see an increase in distant-stage disease across age groups,” said Jeffrey Tosoian, MD, MPH, an assistant professor of urology and director of Translational Cancer Research at Vanderbilt University Medical Center. Tosoian was not involved in the research.
“The hope is that as updated recommendations based on best-available evidence take hold, this trend will reverse, and the harm caused by prostate cancer can be significantly reduced,” he told Healthline.
The report highlights in stark detail consistent disparities in prostate cancer diagnosis and treatment due to race and ethnicity.
Black men have the highest incidence rate of prostate cancer of all racial or ethnic groups — 67% higher than white men. They experience higher rates of the disease at every age compared to white men, and have the lowest age of diagnosis (65 years old) out of all racial groups.
Black men also fare significantly worse disease outcomes than their peers: they are twice as likely to die from prostate cancer as any other racial or ethnic group.
“Though this disparity has improved from a 2.5-fold increase in 2001, it underscores the importance of ensuring equal access to quality healthcare, among other potential factors,” said Tosoian.
Disparities in mortality are present in other groups as well. For example, despite overall lower incidence of prostate cancer among American Indian and Alaska Natives (AIAN), they have a 12% higher mortality rate than White men.
The reason for these disparities is multifactorial and includes factors like:
- later stage diagnosis
- higher prevalence of comorbidities
- barriers to receiving high-quality treatment
“Improving access to care, particularly early detection and high quality treatment, is important for reducing the disparity for Black men,” said
Tyler Kratzer , MPH, first author of the report, and associate research scientist, surveillance research, at the American Cancer Society.“Prior research has shown that when Black men and white men with similar prostate cancer are treated equally, they have equivalent outcomes,” Kratzer told Healthline.
Kratzer and his team also identified significant geographic prostate cancer trends in the United States, which may also be driven by racial disparities. They note that Washington, DC, and Mississippi, the two jurisdictions with the highest death rates from prostate cancer, also have higher proportions of Black residents.
The ACS report suggests that climbing prostate cancer incidence rates, particularly at later stages, may be the result of
declining PSA screening .PSA screening is a simple blood test that measures prostate-specific antigen (PSA) levels. PSA is naturally produced by the prostate gland, but elevated levels may indicate the presence of cancer. PSA testing can detect prostate cancer up to 7 years before it becomes symptomatic.
Despite these benefits, screening is also associated with
overdiagnosis — when a tumor that is unlikely to cause symptoms is treated, leading to unnecessary harm to the patient.How to strike a balance between the harms and benefits of PSA testing is the “central question in the field” according to Tosoian.
In 2018, the USPSTF again
updated its recommendations for PSA screening for males ages 55–69, urging them to “make individual decisions” about the test and discuss potential harms and benefits with their doctor.For patients, navigating these vague recommendations may be difficult.
“The recommendations certainly can be inconsistent from one guideline to the next, yet the majority of them are aligned on major points,” said Tosoian.
“Men with a life expectancy of 10 years or more should consider PSA screening to avoid long-term risk of harm from prostate cancer. The exact age at which guidelines recommend beginning to screen does vary among guidelines, but most agree on beginning in the range of 45 to 55,” he said.
Kratzer suggested that having informed discussions with family members and healthcare practitioners is essential for anyone considering prostate cancer screening.
“Patients should talk with their family members to learn about any history of prostate cancer and then have a conversation with their healthcare provider about if and when screening is in their best interest, beginning at age 50 for most men or earlier for those with higher risk,” he said.
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H5N1 detected in Texas dairy herd; researchers can’t pinpoint source of California child’s illness
After a month with no H5N1 avian flu detections in dairy cattle, the US Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) today reported a positive test involving a herd from Texas, raising the nation’s total since early 2024 to 1,079 infected herds in 17 states.
The detection is Texas’s first since May.
Also, APHIS reported another H5N1 outbreak at a commercial turkey farm, the second recent detection in South Dakota. The new report involves a facility in Beadle County that houses 52,600 birds. Other outbreaks in turkeys over the past week occurred in flocks in Faulk County, South Dakota, and in Dickey County, North Dakota.
Source of California child’s H5N1 infection still a mystery
In related news, investigators from California and their partners at the Centers for Disease Control and Prevention (CDC) yesterday published their investigation findings into one of two unexplained H5N1 infections in California children. They published the details in Morbidity and Mortality Weekly Report.
The school-age child’s symptoms included fever, muscle pain, abdominal pain, and conjunctivitis (“pink eye”). They began on December 13, 2024, lasting 1 week and involving two healthcare visits.
The first visit was at a local emergency department, where staff collected a nasopharyngeal sample that tested positive for influenza A and was sent to the San Francisco Department of Public Health’s lab as part of enhanced surveillance. Further subtyping identified H5N1 on January 9, and follow-up sequencing revealed that the virus belonged to the B3.13 genotype that had been circulating in dairy cattle, other mammals, poultry, and wild birds.
No other family members had been sick, and polymerase chain reaction and serology testing of some of the child’s close contacts revealed no evidence of human-to-human spread. A sample collected from the child on January 10 was still positive, but specimens collected 4 days after that were negative.
Poultry not likely the cause
The family lived in an urban environment and had a pet dog. A family member had bought raw poultry at a live-bird market more than 2 weeks before the child’s symptoms began. It was cooked and eaten the same day. Investigators wrote that poultry wasn’t the likely source, given that poultry-market testing was negative, the child wasn’t exposed to raw poultry, and the parents weren’t sick. The investigators said the child spent time outdoors at school and may have had environmental exposure to the virus.
The researchers said continued surveillance and real-time subtyping at public health labs is a key part of novel flu surveillance and that detection of B3.13 serves as a reminder that the virus continues to transmit across susceptible species, requiring a strong One Health approach.
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Dengue Detected Throughout French Polynesia — Vax-Before-Travel
(Vax-Before-Travel News)French Polynesia, located in the southwest Pacific Ocean, has been a dream vacation destination for decades.
However, these islands are also home to dengue fever, which is transmitted by the bite of infected mosquitoes.
According to Bulletin de surveillance sanitaire de Polynésie française n°34, published on September 2, 2025, there were 22 new dengue cases (19 confirmed last week.
And the blue alert for DENV-1 remains in effect.
Since November 2023, a total of 2,577 cases have been recorded.
To alert international travelers of this health risk, the U.S. CDC’s Travel Health Advisory issued on August 21, 2025, included French Polynesia.
The CDC identified the island groups of the Society Islands (Tahiti, Moorea, and Bora Bora), the Marquesas Islands (Hiva Oa and Ua Huka), and the Austral Islands (Tubuai and Rurutu).
The CDC reported that these countries are experiencing higher-than-usual numbers of cases and have identified a higher-than-expected number of dengue cases among U.S. travelers returning from those countries.
While a second-generation dengue vaccine is available in various countries, it is not offered in the USA.
Fortunately, several dengue vaccine candidates are conducting late-stage research focused on preventing all four virus types from infecting people.
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Do hangover supplements work? – The Economist
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News – Ancient DNA Pinpoints Culprit Responsible for World's First Pandemic – Archaeology Magazine
- News – Ancient DNA Pinpoints Culprit Responsible for World’s First Pandemic Archaeology Magazine
- Ancient DNA finally solves the mystery of the world’s first pandemic ScienceDaily
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