Category: 8. Health

  • Collaborative Strategies to Enhance Care and Data Sharing in LGS

    Collaborative Strategies to Enhance Care and Data Sharing in LGS

    WATCH TIME: 3 minutes | Captions are auto-generated and may contain errors.

    Lennox-Gastaut syndrome (LGS) is a rare epilepsy syndrome that typically begins in childhood and is associated with frequent seizures, cognitive impairment, and long-term disability. Earlier this summer, the LGS Foundation hosted its 3rd biennial LGS Research Meeting of the Minds, held July 21–22, 2025, bringing together caregivers, researchers, health care providers, scientists, advocacy representatives, and industry partners to discuss clinically relevant strategies to advance evidence-based LGS care across the lifespan.

    In collaboration with LGS Foundation, NeurologyLive® held a roundtable discussion with 2 pediatric experts who attended and participated in the meeting. Throughout the panel discussion, the duo covered topics like major gaps in LGS care, fostering connections among diverse stakeholders, and shaping strategies to guide future research. The guests featured in this panel included Scott Perry, MD, head of neurosciences at the Jane and John Justin Neurosciences Center of Cook Children’s Medical Center, and Gita Gupta, MD, MS, assistant professor of pediatrics at the Johns Hopkins University.

    In this second episode, clinicians commented on leveraging existing resources, including the LGS Foundation and the Pediatric Epilepsy Research Consortium (PERC), to standardize clinical data collection and improve comparative effectiveness research in LGS. Experts noted that plans include expanding the LGS patient registry, developing consensus treatment guidelines, and engaging parents as active data stewards through third-party tools that organize and share medical information. The duo underscored that these coordinated efforts aim to improve care delivery, optimize treatment selection, and advance research for the LGS community.

    Transcript edited for clarity. Click here to view more content of the LGS Foundation.

    Isabella Ciccone, MPH: Now that we’ve talked a little bit about the gaps in care, my next question is, what are some actionable strategies proposed during the meeting that can improve care delivery or outcomes for patients with LGS?

    Scott Perry, MD: Yeah. So, just to get back to the gap that I brought up, one of the actionable items is using the resources we have. We’ve got a few really good resources at our disposal with the LGS Foundation. One is that the LGS Foundation has been working fairly closely with PERC, which has an LGS special interest group. That group includes multiple investigators across multiple institutions, who we believe could set up a framework for collecting clinical data in a fairly standardized way. This might allow us to do comparative effectiveness studies to understand which medicines may work better in certain situations, just through the natural history of the way we practice medicine—because we all practice slightly differently and have different medicines that are our preferred first lines—and then we’d be able to compare.

    While that’s not a defined and absolute protocol yet, one of the ideas that came out of it is that we could begin collecting data just during our daily clinical care, writing notes in a similar format. That’s a big step to get people to agree to. That was one thing. The LGS Foundation already has a patient registry that has gotten started, and we talked about expanding upon that to continue collecting more information about what medications patients are using, because that will be another data source we can use.

    There are also several groups. There’s an international group with the International League Against Epilepsy (ILAE), as well as PERC, which is also working on a North American consensus on the treatment of LGS. That will be another source to, if nothing else, give us a foundation of where we start from to then compare.

    Gita Gupta, MS, MS: And there was also a call to action for parents to be more mindful—or they’re already very mindful stewards of their children’s data—but to use third-party commercial companies that are helping parents organize their children’s medical information and synthesize it in a way that is interpretable to a nonmedical person. It was interesting to see that these groups empower parents to share their children’s data with different researchers and organizations that are trying to help children with LGS.

    Continue Reading

  • 5-Day High-Protein, High-Fiber Meal Plan

    5-Day High-Protein, High-Fiber Meal Plan

    Meal Plan at a Glance
    Breakfast/ A.M. Snack Lunch/ P.M. Snack Dinner/ Evening Snack
    Blueberry & peanut chia pudding/ Hard-boiled egg & nuts High-protein black bean salad Charred shrimp pesto bowls/ Dark chocolate
    Blueberry & peanut chia pudding Marry Me white bean salad/ Edamame Crispy salmon bowl/ Chai energy balls
    Black bean & cheese quiche/ Apple High-protein black bean salad Taco-stuffed sweet potato/ Yogurt parfait
    Black bean & cheese quiche/ Apple & nut butter Chopped Cobb salad Chicken & broccoli pasta/ Chai energy balls
    Black bean & cheese quiche/ Yogurt parfait Chopped Cobb salad/ Edamame Turkey fajita bowls

    Day 1

    Charred Shrimp, Pesto & Quinoa Bowls.

    Breakfast (478 Calories) 

    Morning Snack (181 Calories) 

    Lunch (596 Calories)

    Dinner ( 429 Calories)

    Evening Snack ( Calories) 

    • 1 oz. dark chocolate (70-85%)  

    Daily totals:  1,803 calories, 97 g fat, 90 g protein, 161 g carbohydrates, 52 g fiber, 1,821 mg sodium

    To make it 1,500 calories:  Omit morning snack and evening snack. Add  ¼ cup scrambled egg whites to breakfast. 

    To make it 2,000 calories: Add 1 serving Everything Bagel Cottage Cheese Snack Jar with Bell Peppers & Chickpeas to afternoon snack.

    Day 2

    Chai Energy Balls.

    Photographer: Stacy Allen, Food Stylist: Chelsea Zimmer, Prop Stylist: Christina Daley


    Breakfast (478 Calories) 

    Lunch (379 Calories)

    Afternoon Snack (224 Calories) 

    • 1¼ cups frozen edamame (in pods), warmed

    Dinner (526 Calories)

    Evening Snack ( 206 Calories) 

    Daily totals: 1,812 calories, 91 g fat, 102 g protein, 176 g carbohydrates, 48 g fiber, 1,093 mg sodium

    To make it 1,500 calories:  Reduce afternoon snack portion of edamame to ¾ cup and omit evening snack. 

    To make it 2,000 calories: Add 1 serving Everything Bagel Cottage Cheese Snack Jar with Bell Peppers & Chickpeas to morning snack.

    Day 3

    Black Bean & Pepper Jack Quiche.

    Photographer: Jen Causey, Food Stylist: Emily Nabors Hall, Prop Stylist: Julia Bayless.


    Breakfast (332 Calories)

    Morning Snack (78 Calories) 

    Lunch (596 Calories)

    Dinner (510 Calories)

    Evening  Snack ( 301 Calories) 

    Daily totals: 1,815 calories, 83 g fat, 97 g protein, 186 g carbohydrates, 45 g fiber, 1,737 mg sodium.

    To make it 1,500 calories:  Omit evening snack.

    To make it 2,000 calories: Add 1 serving Everything Bagel Cottage Cheese Snack Jar with Bell Peppers & Chickpeas to afternoon snack. 

    Day 4

    Chopped Cobb Salad.

     Breakfast (332 Calories)

    Morning Snack ( 268 Calories) 

    • 1 small apple + 2 Tbsp. natural peanut butter 

    Lunch ( 481 Calories) 

    Dinner (530 Calories) 

    Evening Snack ( 206 Calories) 

    Daily totals: 1,816 calories, 82 g fat, 94 g protein, 195  g carbohydrates, 38 g fiber, 1,428 mg sodium

    To make it 1,500 calories: Reduce to 1 Tbsp. peanut butter at morning snack. Omit evening snack. 

    To make it 2,000 calories: Add 1 serving Everything Bagel Cottage Cheese Snack Jar with Bell Peppers & Chickpeas to afternoon snack. 

    Day 5

    Ground Turkey Rice Bowl.

    Photographer: Jen Causey, Food Stylist: Margaret Monroe Dickey, Prop Stylist: Hannah Greenwood.


    Breakfast (332 Calories)

    Morning Snack ( 301 Calories) 

    Lunch ( 481 Calories) 

    Afternoon Snack (135 Calories) 

    • ¾ cup frozen edamame (in pods), warmed

    Dinner (570 Calories)

    Daily totals:  1,818 calories,  74 g fat, 110 g protein, 202 g carbohydrates, 40 g fiber,  1,501 mg sodium

    To make it 1,500 calories:  Omit morning snack. 

    To make it 2,000 calories: Add 1 oz. dark chocolate (70-85%) and 1 Tbsp. almonds to evening snack. 

    Frequently Asked Questions


    • Is it OK to mix and match meals if there’s one I don’t like?

      Yes! This meal plan is meant to serve as inspiration. It doesn’t need to be followed exactly to reap the benefits. When choosing recipes, we made sure to check the calories, fiber, protein and sodium to align with the parameters of this plan and be within our sodium limits. If you’re making a recipe swap, it may be helpful to choose a recipe with similar calories, fiber, protein and sodium levels. For more inspiration, check out these delicious High-Protein, High-Fiber Dinners That Are Easy to Make.


    • Can I eat the same breakfast or lunch every day?

      Definitely, it’s fine to eat the same breakfast or lunch every day. The breakfasts range from 332 to 478 calories, while the lunches span 379 to 596 calories. These ranges are fairly close, though if you’re closely monitoring your calories or other nutrients, like protein, you may want to adjust a snack or two.


    • Why is there not a 1,200-calorie modification?

      We no longer provide modifications for 1,200-calorie days in our meal plans. The 2020-2025 Dietary Guidelines for Americans suggests that limiting calories to 1,200 per day is too low for most people to meet their nutritional needs, plus it’s unsustainable for long-term health and well-being.

    Health Benefits of a High-Protein, High-Fiber Diet

    Protein is found in every cell in our body. Because of this, it’s essential for countless bodily functions like bone and muscle health, digestion and energy production. While most people get enough protein, certain factors like activity level, age or health goals may amp up your needs. 

    On the flip side, diets that are too high in protein can sometimes lack fiber, which may lead to digestive troubles. Striking the right balance of both protein and fiber is key to keeping your body healthy and running smoothly. Fiber brings its own powerful set of benefits. Diets rich in fiber have been linked to healthier weight loss and long-term weight control, a lower risk of type 2 diabetes and heart disease, reduced odds of certain cancers, more regular bowel movements and even a longer life. 

    Together, protein and fiber help you feel full and satisfied after meals, support digestion and keep your energy steady throughout the day. Talk about a winning combo for health and well-being! 

    How We Create Meal Plans

    Registered dietitians thoughtfully create EatingWell’s meal plans to be easy-to-follow and delicious. Each meal plan meets specific parameters depending on the health condition and/or lifestyle goal it is targeting and is analyzed for accuracy using the nutrition database, ESHA Food Processor. As nutritional needs differ from person to person, we encourage you to use these plans as inspiration and adjust as you see fit.

    Dig Deeper

    The 7 Best High-Protein Foods to Eat as Snacks, According to Dietitians

    9 Out of 10 Americans Don’t Get Enough Fiber—Here’s How Much You Really Need

    Continue Reading

  • Measles comeback: Will they evolve enough to evade the vaccine? – NewsNation

    1. Measles comeback: Will they evolve enough to evade the vaccine?  NewsNation
    2. US measles total climbs to 1,431 cases  CIDRAP
    3. Declining U.S. Vaccination Rate in Spotlight as Measles Reaches Idaho | Best States | U.S. News  U.S. News & World Report
    4. What Parents Need To Know About Measles As Kids Head Back To School  Forbes
    5. Opinion | Are You Ready for Measles’ Wrath?  MedPage Today

    Continue Reading

  • Total Control 24 Review 2025: Prostate Support Supplement for Urinary Flow, Bladder Health, and Men’s Wellness

    Total Control 24 Review 2025: Prostate Support Supplement for Urinary Flow, Bladder Health, and Men’s Wellness

    This content is for informational purposes only and does not replace professional medical advice. If you purchase through links in this article, we may receive a commission. Always check the official website for the most current pricing and details as they are subject to change at any time.

    Total Control 24 (TC24) Review 2025: Does This Prostate Support Supplement Really Work?

    TL;DR Summary: Total Control 24 (TC24) is a prostate support supplement designed to help men maintain urinary flow, bladder health, and confidence as they age. This review explores the formula, research, user experiences, and official pricing details in 2025.

    In This Article, You’ll Discover:

    • Why prostate health is critical for men over 40 in 2025.

    • What makes Total Control 24 (TC24) unique compared to other supplements.

    • The science behind TC24’s natural ingredients and their studied benefits.

    • How men are using TC24 daily for urinary and prostate support.

    • What experts and researchers say about natural prostate health solutions.

    • Where to find TC24’s latest pricing, packages, and guarantee options.

    • Key FAQs about safety, results, and responsible supplement use.

    Introduction: Why Prostate Support Supplements Matter in 2025

    For millions of men over 40, prostate health has become one of the most pressing wellness concerns of the decade. Age-related changes can affect urinary flow, bladder control, energy, and overall quality of life. In 2025, lifestyle stressors, environmental factors, and changing dietary habits are placing even greater pressure on men’s prostate health, making early prevention and daily support more critical than ever.

    Medical statistics continue to show that an enlarged prostate, urinary frequency, or interrupted sleep due to nighttime trips to the bathroom are among the top reasons men seek solutions for confidence and comfort. While regular checkups and professional medical advice remain the gold standard, many men are also turning to natural prostate support supplements for additional daily balance.

    The demand for supplements like Total Control 24 (TC24) reflects this trend. These formulations are designed with carefully selected plant-based compounds, vitamins, and minerals that are widely researched for their potential role in supporting prostate and urinary health. For men seeking proactive options in 2025, supplements provide a convenient and accessible way to reinforce healthy function alongside medical guidance and lifestyle improvements.

    Today’s buyers are more informed than ever, which means they are looking not just for “quick fixes,” but for comprehensive solutions backed by science, transparent ingredient sourcing, and real-world testimonials. Prostate support supplements fit into this evolving mindset by offering men a way to take control of their daily wellness routine without depending solely on reactive measures.

    If you’ve been considering whether a prostate support supplement belongs in your routine, 2025 is a pivotal year to make that decision. In the sections that follow, we’ll break down how Total Control 24 (TC24) works, the latest research behind its ingredients, and whether it can help you or someone you care about achieve better balance, confidence, and peace of mind.

    Visit the Official Total Control 24 Website

    What Is Total Control 24 (TC24) and How Does It Work?

    Total Control 24 (TC24) is a dietary supplement formulated to support men’s prostate and urinary health through a blend of natural plant extracts, vitamins, and minerals. Unlike prescription medications that address prostate conditions directly under a doctor’s care, TC24 belongs to the category of wellness supplements-products designed to complement lifestyle habits, diet, and regular medical checkups.

    At its core, TC24 was developed with the goal of helping men:

    • Maintain normal urinary flow and frequency.

    • Support bladder control during the day and night.

    • Reinforce prostate tissue health as part of long-term wellness.

    • Promote overall confidence and comfort in daily life.

    The Formula Philosophy

    The TC24 formula is built around ingredients that are commonly studied for their role in male wellness.

    While every supplement is unique, compounds often associated with prostate support include:

    • Botanical extracts known for their antioxidant and anti-inflammatory properties.

    • Minerals like zinc and selenium, which are essential for male reproductive health.

    • Herbal ingredients historically linked to urinary comfort and flow regulation.

    Each capsule is designed for once- or twice-daily use, offering men a practical and accessible way to incorporate prostate support into their existing routines.

    How It Works in Daily Life

    Rather than acting as a “cure,” TC24 works by supporting the body’s natural processes. The ingredients are chosen to complement balanced hormone activity, aid bladder function, and help men manage age-related urinary concerns. By addressing multiple angles-nutritional gaps, antioxidant protection, and bladder comfort-TC24 aims to give men a sense of greater control over their day-to-day experiences.

    Why Men Choose Supplements Like TC24

    In 2025, many men are seeking solutions that are:

    • Natural – built around botanicals and nutrients instead of synthetic drugs.

    • Preventive – helping to protect long-term prostate wellness before issues escalate.

    • Convenient – easy to use without major lifestyle changes.

    Supplements like TC24 fit these demands, offering peace of mind and proactive support in an easy-to-manage format.

    Explore the 2025 Science Behind Total Control 24

    Best Prostate Support Options and Benefits in 2025

    The market for men’s prostate health solutions has grown more diverse than ever. From prescription medications and surgical procedures to lifestyle adjustments and natural supplements, men have a wide range of options to consider. While medical treatment remains essential for those with diagnosed conditions, prostate support supplements offer a preventive and complementary pathway that appeals to health-conscious men worldwide.

    The Growing Popularity of Prostate Supplements

    Men today are more proactive about wellness than previous generations.

    Rising awareness around prostate health has fueled demand for natural supplements that:

    • Support urinary comfort during the day and night.

    • Help maintain regular bladder function.

    • Reinforce long-term prostate tissue wellness.

    • Provide antioxidant protection for cellular health.

    • Fit seamlessly into daily routines without major lifestyle disruptions.

    How Total Control 24 Stands Out

    Among prostate supplements available in 2025, Total Control 24 (TC24) has gained attention for its focus on:

    • Comprehensive formulation – designed to target multiple aspects of prostate and urinary wellness.

    • Natural ingredient base – plant extracts, vitamins, and minerals often studied for men’s health.

    • Convenience – easy-to-use capsules that require no complicated dosing schedules.

    • Transparency – a formula backed by publicly available ingredient information.

    This combination of science-aligned formulation and consumer convenience makes TC24 a practical choice for men seeking everyday support.

    Benefits Men Report from Prostate Support Supplements

    While individual experiences vary, men commonly look for supplements that help with:

    • Fewer nighttime bathroom trips.

    • A more consistent urinary flow.

    • Improved confidence in social and professional settings.

    • Better sleep quality due to reduced interruptions.

    • General peace of mind from knowing they are supporting long-term wellness.

    Supplements like TC24 are not intended as replacements for medical care but serve as an extra layer of support for men who want to stay ahead of age-related challenges.

    See Consumer Insights on Total Control 24

    How to Use Total Control 24 in Daily Life

    When it comes to supplements, consistency is the key to seeing results. Total Control 24 (TC24) was designed to fit seamlessly into a man’s everyday wellness routine, making it easy to use without complicated instructions or lifestyle overhauls.

    Daily Serving and Usage Guidelines

    According to product directions, TC24 is typically taken once or twice daily with water. The capsule format makes it convenient to integrate into morning or evening routines, whether alongside a meal or as part of a supplement stack. This design ensures that men can support prostate and urinary health without adding unnecessary complexity to their day.

    Making TC24 Part of Your Routine

    Here are a few common ways men incorporate TC24:

    • Morning boost: Taking it alongside a multivitamin or breakfast ensures it becomes a habit.

    • Workday wellness: Keeping the bottle in a desk drawer or briefcase makes it easier to stay consistent during busy schedules.

    • Evening support: Pairing TC24 with dinner or a bedtime routine helps align supplementation with daily winding-down habits.

    The goal is to establish a rhythm that works best for the individual, ensuring regular use for maximum effectiveness.

    Lifestyle Synergy for Better Results

    Supplements like TC24 work best when paired with broader lifestyle efforts, such as:

    • Maintaining a balanced diet rich in fruits, vegetables, and whole grains.

    • Staying physically active to promote circulation and overall metabolic health.

    • Limiting excessive caffeine or alcohol intake, which can contribute to urinary irritation.

    • Keeping up with annual checkups and professional guidance for long-term health.

    By combining TC24 with these healthy practices, men can create a more holistic approach to supporting prostate function.

    Why Consistency Matters in 2025

    Inconsistent supplement use is one of the top reasons many men fail to notice benefits. By making TC24 part of an established routine, users are more likely to give their bodies the consistent support they need over time.

    Expert Insights and Industry Research on Prostate Health Supplements

    Prostate health has been the subject of extensive study for decades, with researchers and clinicians consistently emphasizing the importance of early preventive care. In 2025, the focus is shifting from reactive treatment to proactive wellness strategies, which include lifestyle adjustments, medical monitoring, and in many cases, nutritional supplementation.

    What the Research Says

    Peer-reviewed studies and clinical observations suggest several key factors in maintaining long-term prostate wellness:

    • Nutritional balance matters. Men with diets low in essential micronutrients such as zinc and selenium may face higher risks of prostate-related concerns as they age.

    • Botanicals show promise. Plant extracts like saw palmetto, beta-sitosterol, and pygeum africanum have been researched for their potential role in supporting urinary flow and reducing discomfort.

    • Lifestyle and diet remain critical. High-fiber diets, reduced red meat intake, and regular exercise are consistently linked to better overall prostate outcomes.

    • Age remains a defining factor. Most men over 50 experience some degree of prostate enlargement or urinary changes, making preventive strategies increasingly valuable.

    Expert Commentary in 2025

    Industry experts highlight that men are no longer waiting until symptoms worsen before taking action. Instead, they are turning to science-aligned supplements as a daily measure for reassurance and balance. Wellness professionals often recommend supplements as an adjunct-not a replacement-for healthy living and professional care.

    As one health researcher noted: “Prostate supplements are not cures, but they provide a convenient way for men to bridge nutritional gaps and support daily comfort.” This reflects a growing consensus in the health community: supplementation works best as part of a bigger lifestyle equation.

    How TC24 Fits Into the Evidence-Based Picture

    Total Control 24 (TC24) was developed with these insights in mind, incorporating ingredients that align with research trends in prostate and urinary health. While no supplement can guarantee results for every individual, TC24’s formulation reflects an evidence-informed approach, appealing to men who value both modern science and natural wellness traditions.

    For men in 2025 who want to stay proactive, TC24 offers a simple way to integrate this research-backed strategy into their daily lives.

    Success Stories, Testimonials, and User Experiences with TC24 Reviews

    One of the most powerful ways to understand the impact of a supplement is through the voices of those who have tried it. In 2025, men from all walks of life are sharing their experiences with Total Control 24 (TC24), and their stories highlight why this product is gaining traction as a trusted choice in the prostate health category.

    Real-World Experiences

    While individual outcomes always vary, customer reviews commonly point to:

    • Improved urinary flow. Men frequently mention a smoother, more consistent bathroom experience compared to before.

    • Fewer nighttime disruptions. Many users note reduced trips to the bathroom at night, which translates into more restful sleep.

    • Daily confidence. Several testimonials highlight renewed confidence in social and professional settings thanks to fewer interruptions or concerns.

    • General wellness support. Customers often describe a sense of taking proactive control over their health, rather than waiting for problems to escalate.

    Stories That Resonate

    • Active professionals report that TC24 helps them maintain focus throughout the workday without constant interruptions.

    • Retired men often express appreciation for feeling more comfortable and secure in their daily activities.

    • Health-conscious individuals describe TC24 as a convenient way to complement their fitness, nutrition, and wellness routines.

    The Importance of Balance

    It’s important to emphasize that no supplement works the same for everyone. Some men report noticeable changes within weeks, while others experience more gradual benefits. This variability reflects the fact that prostate health is influenced by many factors, including age, lifestyle, and genetics.

    However, the consistent theme across testimonials is that TC24 helps men feel more in control-supporting not only physical wellness but also peace of mind.

    Learn How Others Use Total Control 24 Successfully

    Comparing Prostate Supplements vs Alternatives in 2025

    When it comes to prostate health, men today have more options than ever before. Each approach offers its own advantages and limitations, and the best choice often depends on individual needs, goals, and medical advice.

    1. Lifestyle Adjustments

    Doctors consistently recommend lifestyle changes as the foundation for prostate wellness.

    • These include:

      • Eating a balanced diet rich in fruits, vegetables, and whole grains.

      • Staying physically active to promote circulation and hormone balance.

      • Reducing intake of caffeine, alcohol, and processed foods that can irritate the bladder.

      • Managing stress, which is increasingly linked to urinary symptoms.

    • Strengths: Safe, natural, long-term benefits.

    • Limitations: Requires discipline, and improvements may take months to show.

    2. Prescription Medications

    For men with diagnosed prostate enlargement or more advanced urinary issues, prescription treatments are often recommended. These include alpha-blockers or hormone-based therapies.

    • Strengths: Clinically proven and often effective under medical supervision.

    • Limitations: May come with side effects, require regular doctor visits, and are usually reserved for more severe cases.

    3. Surgical Procedures

    In some cases, surgery is considered when symptoms are severe or other treatments fail.

    • Strengths: Can provide immediate relief in critical situations.

    • Limitations: Invasive, requires recovery time, and carries risks that many men prefer to avoid unless absolutely necessary.

    4. Prostate Support Supplements

    Supplements like Total Control 24 (TC24) provide men with a proactive, preventive-friendly alternative.

    • They are designed to:

      • Support urinary comfort and flow.

      • Reinforce prostate tissue wellness.

      • Offer antioxidant support for long-term cellular health.

      • Deliver daily confidence without invasive or pharmaceutical intervention.

    • Strengths: Natural, accessible, easy to use, and supportive of long-term wellness goals.

    • Limitations: Not a cure or substitute for medical treatment; results vary between individuals.

    Why TC24 Earns Attention in 2025

    In comparing these options, TC24 stands out because it strikes a balance between convenience, affordability, and preventive support. While lifestyle and medical care remain essential, supplements like TC24 bridge the gap-helping men feel proactive about their health without waiting for issues to worsen.

    By combining TC24 with healthy habits and regular medical checkups, men can create a holistic approach to prostate wellness that aligns with modern health priorities in 2025.

    Safety, Risks, and Responsible Use of Prostate Supplements

    When considering any supplement, safety should always come first. Total Control 24 (TC24), like other prostate support products, is formulated with natural ingredients intended to complement a healthy lifestyle. Still, it is important for men to approach supplementation with a balanced perspective.

    General Safety Profile

    Most prostate supplements, including TC24, are made with vitamins, minerals, and plant-based compounds that are widely regarded as safe when taken as directed. Users typically tolerate these formulations well, and they are often chosen for their gentle, daily-use potential.

    Possible Risks and Considerations

    Even natural supplements can pose risks if used improperly or without awareness of personal health factors.

    Points to consider include:

    • Interactions with medications: Some ingredients may interact with prescription drugs, particularly those for blood pressure, hormones, or urinary conditions.

    • Individual sensitivities: Men with allergies to botanicals, seeds, or herbal extracts should review ingredient lists carefully.

    • Overuse risks: Taking more than the recommended serving does not accelerate benefits and may increase the chance of side effects.

    • Underlying conditions: Supplements are not a substitute for medical care. Persistent urinary issues should always be discussed with a healthcare provider.

    Responsible Use Guidelines

    To maximize safety and effectiveness, men should follow these practices:

    • Consult with a healthcare professional before starting any new supplement, especially if already on medication.

    • Follow label directions precisely-more is not better.

    • Stay consistent with daily use rather than sporadic dosing.

    • Pair with healthy habits such as balanced diet, hydration, and regular exercise.

    Transparency and Trust in 2025

    The supplement industry has grown more regulated and transparent in recent years, with consumers demanding clear ingredient labeling and responsible marketing. Products like TC24 are built to align with these expectations, offering men a safe and accessible way to support wellness while respecting compliance standards.

    By approaching supplementation responsibly, men can enjoy the benefits of natural support while minimizing potential risks.

    Pricing, Packages, and Official Website for Total Control 24

    For men considering a prostate support supplement, cost and accessibility are important factors. Total Control 24 (TC24) is sold exclusively through its official channels, ensuring product authenticity and access to the latest promotional offers.

    Where to Buy TC24

    The only secure place to purchase TC24 is through the official website. This protects buyers from counterfeit products and ensures they receive the manufacturer’s full customer support, guarantees, and refund policies.

    Package Options in 2025

    While package availability may vary, prostate health supplements like TC24 typically offer tiered purchasing options, such as:

    • Single-bottle starter option for first-time users.

    • Multi-bottle bundles that provide greater value and convenience for long-term use.

    • Special promotions or limited-time discounts, depending on the season or campaign.

    These options are designed to help men choose between trying TC24 for a short period or committing to consistent support over several months.

    Refunds and Guarantees

    Supplements in this category often include money-back guarantees, giving customers confidence to try the product risk-free. TC24 emphasizes transparency and consumer trust, making it easier for men to explore the supplement without long-term financial risk.

    Why Buying Direct Matters

    By purchasing through the official website, customers can:

    • Access the most current promotions.

    • Ensure product authenticity and freshness.

    • Take advantage of refund or satisfaction guarantees.

    • Receive customer service directly from the manufacturer.

    Pricing Disclaimer: Always check the official website for the most current pricing and package details, as they are subject to change at any time.

    Check Current Pricing for Total Control 24

    Frequently Asked Questions About Total Control 24 Prostate Health Supplements

    What is Total Control 24 (TC24)?

    Total Control 24 is a prostate support supplement designed with natural ingredients, vitamins, and minerals to help men support urinary comfort, bladder control, and overall prostate wellness. It is not a prescription drug but rather a wellness-focused daily supplement.

    How long does it take to notice results?

    Results vary depending on the individual. Some men report changes in comfort and bathroom frequency within a few weeks, while for others the benefits may appear more gradually over several months of consistent use.

    Can I take TC24 with other medications?

    If you are taking prescription medications, especially those for blood pressure, hormones, or urinary health, it’s important to consult your healthcare provider before starting TC24 or any supplement.

    Is TC24 safe to take long-term?

    TC24 is formulated for daily use and is generally well tolerated. Most men use it consistently as part of their long-term wellness routines. However, the safest approach is to confirm with your doctor before prolonged use, especially if you have underlying conditions.

    What makes TC24 different from other prostate supplements?

    TC24 stands out for its comprehensive formulation, which combines plant-based extracts, essential minerals, and other nutrients studied for men’s health. It also emphasizes transparency, convenience, and an evidence-informed design.

    Can prostate supplements replace medical treatment?

    No. Supplements like TC24 are designed to support wellness and daily comfort but should never replace medical advice, diagnosis, or treatment. Persistent or severe urinary issues should always be addressed with a qualified healthcare professional.

    Where can I buy TC24?

    The only safe and authorized source is the official website. Buying directly ensures authenticity, access to current promotions, and eligibility for any money-back guarantees.

    What if TC24 doesn’t work for me?

    Every man’s body responds differently. TC24 comes with refund and satisfaction policies through the official website, allowing customers to try it without long-term financial risk.

    Final Verdict: Is Total Control 24 the Best Prostate Support Supplement for You?

    Prostate health is not something most men think about until urinary discomfort, sleep disruptions, or confidence issues begin to surface. In 2025, with growing awareness around preventive care, men are seeking solutions that are safe, natural, and convenient.

    Total Control 24 (TC24) stands out as a leading choice for those who want:

    • A science-aligned supplement designed to support urinary flow and bladder comfort.

    • A natural, plant-based formula free from complicated dosing or invasive procedures.

    • A daily wellness routine that reinforces confidence and long-term prostate support.

    • Transparent ingredient information and direct purchase security through the official website.

    It’s important to note that TC24 is not a cure or medical treatment. Instead, it offers men a proactive way to reinforce their wellness journey, complementing healthy habits and professional medical care.

    For men who value consistency, convenience, and preventive health measures, TC24 provides a balanced solution that aligns with today’s wellness standards. Backed by transparent labeling and customer feedback, it has earned its reputation as a trusted choice in the prostate supplement category.

    Who Should Consider TC24?

    • Men over 40 who want to be proactive about urinary and prostate health.

    • Individuals seeking natural, non-prescription support for comfort and balance.

    • Health-conscious men who combine supplementation with diet, exercise, and routine checkups.

    If these points resonate with you, TC24 may be a strong addition to your daily health strategy.

    Apply or Subscribe to Total Control 24 Today

    Bonus Section: Strategic Ways to Maximize Prostate Health in 2025

    Supporting prostate health requires more than just taking a supplement – it’s about building a lifestyle that encourages long-term wellness. In 2025, experts emphasize combining natural support like Total Control 24 (TC24) with proven daily strategies to maximize comfort, energy, and overall confidence.

    1. Prioritize a Prostate-Friendly Diet

    • Incorporate tomatoes, berries, and leafy greens for antioxidants.

    • Include foods rich in zinc and selenium, such as nuts, seeds, and seafood.

    • Limit processed foods, excessive red meat, and high-sodium meals that may stress the urinary system.

    2. Stay Physically Active

    Exercise not only improves circulation but also helps regulate hormones that influence prostate function. Aim for at least 30 minutes of moderate activity most days of the week.

    3. Manage Stress and Sleep

    Chronic stress is increasingly linked to urinary challenges. Incorporating mindfulness, breathing exercises, or yoga can help. Quality sleep also supports hormone regulation and overall body balance.

    4. Stay Hydrated – But Time Your Intake

    Proper hydration is essential, but men experiencing nighttime bathroom trips may find it helpful to reduce fluid intake a few hours before bedtime while staying well-hydrated throughout the day.

    5. Supplement Wisely

    Adding Total Control 24 (TC24) to your daily routine offers targeted support, but consistency is key. Combining TC24 with these lifestyle strategies gives men the best chance of reinforcing prostate and urinary health naturally.

    6. Don’t Skip Medical Checkups

    Supplements and healthy habits are valuable tools, but nothing replaces professional screenings. Regular checkups remain the gold standard for monitoring prostate health and catching issues early.

    The Bottom Line: By pairing Total Control 24 with smart nutrition, exercise, hydration, and medical care, men can create a comprehensive plan that maximizes wellness in 2025 and beyond.

    Contact Information

    For questions, product support, or refund inquiries regarding Total Control 24 (TC24), please use the official contact channels below:

    • Company: Total Control 24

    • Email: support@buytc24.com

    • Phone (US): 1-814-885-4823 Monday – Friday

    Always purchase directly through the official website to ensure product authenticity, access to promotions, and eligibility for satisfaction guarantees.

    Disclaimers

    This article contains affiliate links. If you purchase a product through the links provided, we may earn a commission at no additional cost to you. This supports our ability to create research-based, high-quality content.

    The information in this article is provided for educational and informational purposes only. It is not intended to replace professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or another qualified healthcare provider with any questions regarding a medical condition or before starting any new supplement, diet, or exercise program.

    Results from using supplements such as Total Control 24 (TC24) vary from person to person. No supplement can guarantee identical outcomes for all users. Testimonials and customer experiences are individual opinions and should not be interpreted as typical or guaranteed results.

    All product details, including ingredients, guarantees, and pricing, are accurate at the time of writing but are subject to change at any time. Always verify the latest information directly from the official website.

    If this content references promotions, guarantees, or refund policies, please note that terms may vary and are provided directly by the product’s official manufacturer or distributor. Always review the full terms and conditions at the official source before purchasing.

    Source: Total Control 24

    Continue Reading

  • Scrolling on the toilet increases hemorrhoid risk, study says

    Scrolling on the toilet increases hemorrhoid risk, study says

    Sitting on the toilet for extended amounts of time while scrolling a cell phone may increase risk for hemorrhoids, according to a study. Photo by Adobe Stock

    Do you use your time on the john to catch up on the news, go through your e-mail or check out social media?

    Be careful — you might be more likely to develop hemorrhoids, new research shows.

    Folks who use a smartphone on the toilet have a 46% higher risk of hemorrhoids than those who don’t, researchers reported in the journal PLOS One.

    Smartphone use might inadvertently prolong toilet time, potentially increasing pressure on the anus and contributing to hemorrhoids, researchers explained.

    “We’re still uncovering the many ways smartphones and our modern way of life impact our health,” senior researcher Dr. Trisha Pasricha, a gastroenterologist at Beth Israel Deaconess Medical Center in Boston, said in a news release. “It’s possible that how and where we use them — such as while in the bathroom — can have unintended consequences.”

    Hemorrhoids are swollen veins in the anal or rectal area that often cause pain or bleeding. They’re thought to occur due to increased pressure that occurs during pregnancy, with excess weight, or through straining during bowel movements, Harvard Medical School says.

    For the new study, researchers surveyed 125 adults undergoing colonoscopy at Beth Israel Deaconess Medical Center. About 43% of the participants had hemorrhoids.

    Two-thirds of the participants, or 66%, told researchers they use smartphones while on the toilet. Reading news and using social media were the most commonly reported smartphone activities in the bathroom.

    Using a smartphone while on the toilet was linked to a 46% increased risk of hemorrhoids, even after researchers accounted for other factors like exercise habits, age and fiber intake.

    Those who use smartphones tended to spend more time on the can, researchers found. About 37% of smartphone users spent more than five minutes at a time on the toilet, compared to just 7% of non-users.

    “It’s incredibly easy to lose track of time when we’re scrolling on our smartphones — popular apps are designed entirely for that purpose,” Pasricha said. “But it’s possible that constantly sitting longer on the toilet than you intended because you’re distracted by your smartphone could increase your risk of hemorrhoids,” she said.

    The study bolsters common-sense advice, Pasricha said.

    “Leave the smartphones outside the bathroom and to try to spend no more than a few minutes to have a bowel movement,” she said. “If it’s taking longer, ask yourself why. Was it because having a bowel movement was really so difficult, or was it because my focus was elsewhere?”

    More information

    Harvard Medical School has more on hemorrhoids.

    Copyright © 2025 HealthDay. All rights reserved.

    Continue Reading

  • Claims at Reform conference that vaccines gave royals cancer ‘extremism’, says Streeting | Politics News

    Claims at Reform conference that vaccines gave royals cancer ‘extremism’, says Streeting | Politics News

    A vaccine-sceptic doctor has told the Reform UK conference that COVID vaccines contributed to cancer in the royal family – to criticisms of “extremism” from the health secretary and condemnation from experts.

    Dr Aseem Malhotra spent around a quarter of an hour presenting a series of claims on the main stage of the conference in Birmingham – with thousands present in the crowd.

    Dr Malhotra, who described himself as a friend of controversial US health secretary Robert F Kennedy Jr, said hundreds of studies showed the harms of mRNA vaccines.

    He went on to say that he agreed with another doctor that “it’s highly likely that the COVID vaccines have been a factor, a significant factor, in the cancer of members of the royal family.”

    Politics latest: Starmer continues ministerial reshuffle

    Sky News has contacted Buckingham Palace for comment.

    The comments were met with silence from the audience in the room.

    Wes Streeting, the Labour MP and health secretary, was quick to criticise Dr Malhotra.

    He said: “When we are seeing falling numbers of parents getting their children vaccinated, and a resurgence of disease we had previously eradicated, it is shockingly irresponsible for Nigel Farage to give a platform to these poisonous lies.

    “Farage should apologise and sever all ties with this dangerous extremism.”

    Read more:
    Inside the fight over vaccines in the US
    Why are child vaccination rates the lowest in decade

    Image:
    Dr Aseem Malhotra at the Reform UK conference. Pic: PA

    Blood Cancer UK’s healthcare professional advisory panel, which is made up of specialists from across the UK, said: “There are no controlled, large-scale studies (studies with the most robust scientific evidence) that demonstrate an increased cancer risk following COVID-19 vaccination.”

    Brian Ferguson, a professor of viral immunology and the University of Cambridge, said: “There is no credible evidence that these vaccines disrupt tumour suppressors or drive any kind of process – biochemical or otherwise – that results in cancer.

    “It is particularly crass to try to link this pseudoscience to the unfortunate incidents of cancer in the royal family and is reminiscent of the ‘died suddenly’ trope which attempted – and ultimately failed – to link the death of any young person to their vaccination status.

    “This kind of outlandish conspiracy theory only serves to undermine the credibility of those spreading it.”

    Health Secretary Wes Streeting has called the remarks 'extremism'. Pic: PA
    Image:
    Health Secretary Wes Streeting has called the remarks ‘extremism’. Pic: PA

    Lord Bethell, the Conservative peer and former health minister, said: “This [is] bad science, bad royal-watching and bad politics – the British public strongly support vaccines and resent people who try to hijack our much-loved royal family for promoting loopy ideas.

    “Might work well with American donors, but this is a clanger for Reform UK‘s credibility. I hope they give up this rubbish.”

    A spokesperson for Reform UK said: “Dr Aseem Malhotra is a guest speaker with his own opinions who has an advisory role in the US government. Reform UK does not endorse what he said but does believe in free speech.”

    Continue Reading

  • Study Finds Link Between Impaired Spatial Orientation in Virtual Tests and Higher Alzheimer’s Risk – geneonline.com

    Study Finds Link Between Impaired Spatial Orientation in Virtual Tests and Higher Alzheimer’s Risk – geneonline.com

    1. Study Finds Link Between Impaired Spatial Orientation in Virtual Tests and Higher Alzheimer’s Risk  geneonline.com
    2. Impaired spatial orientation found in older adults at risk for Alzheimer’s disease  News-Medical
    3. How you MOVE could reveal an early sign of Alzheimer’s disease – long before memory loss  The US Sun
    4. What your spatial awareness reveals about your dementia risk  BBC Science Focus Magazine
    5. Study Links Impaired Spatial Orientation in Virtual Environments to Higher Alzheimer’s Dementia Risk  geneonline.com

    Continue Reading

  • Air Pollution Linked to Toxic Protein Clumps Driving Lewy Body Dementia

    Air Pollution Linked to Toxic Protein Clumps Driving Lewy Body Dementia

    Summary: A new study reveals a molecular link between fine particulate air pollution (PM2.5) and Lewy body dementia, a devastating neurodegenerative condition. By combining human epidemiological data and animal experiments, researchers showed that PM2.5 exposure triggers toxic clumps of alpha-synuclein in the brain, similar to those seen in patients.

    Mice exposed to pollution developed brain atrophy, cognitive decline, and widespread protein clumps, while mice without alpha-synuclein showed no symptoms. The findings highlight pollution as a potential driver of dementia and a promising avenue for preventive strategies and drug development.

    Key Facts:

    • Pollution Link: PM2.5 exposure increases risk of Lewy body dementia by up to 17%.
    • Protein Trigger: Airborne particles induce toxic alpha-synuclein clumps in mouse and human brains.
    • Drug Target Potential: A newly identified pollution-related Lewy body strain may guide future treatments.

    Source: Columbia University

    A team of researchers found there is a possible molecular connection between air pollution and an increased risk of developing Lewy body dementia. 

    The study builds on a decade of research linking exposure to fine particulate air pollution (PM2.5) — from industrial activity, residential burning, wildfires, and vehicle exhaust—to a higher risk of developing these diseases.

    The findings add to a growing body of evidence indicating how environmental factors may trigger harmful protein changes in the brain that lead to neurodegeneration.

    The team focused on patients hospitalized for the first time with Lewy body-related conditions and used ZIP-code-level data to estimate their long-term exposure to PM2.5. Credit: Neuroscience News

    The research is published in Science.

    Lewy body diseases are a group of neurodegenerative disorders marked by the abnormal buildup of a protein, alpha-synuclein, in the brain. These clumps, known as Lewy bodies, are a hallmark of the conditions Parkinson’s disease and Lewy body dementia.

    In their new work, the team discovered that exposing mice to PM2.5 triggered the formation of abnormal alpha-synuclein clumps. These toxic protein clusters shared key structural and disease-related features with those found in the brains of patients with Lewy body dementia.

    “We have identified a novel strain of Lewy bodies formed after exposure to air pollution,” says corresponding author Xiaobo Mao, PhD, associate professor of neurology at the Johns Hopkins University School of Medicine and a member of the Johns Hopkins Institute for Cell Engineering. 

    “By defining this strain, we hope to establish a specific target for future drugs aimed at slowing the progression of neurodegenerative diseases marked by Lewy bodies.”

    The research began with an analysis of hospital data from 56.5 million U.S. patients admitted between 2000 and 2014 with neurodegenerative diseases. The team focused on patients hospitalized for the first time with Lewy body-related conditions and used ZIP-code-level data to estimate their long-term exposure to PM2.5. 

    The scientists found that each interquartile range increase of in PM2.5 concentration in these zip code areas resulted in a 17 percent higher risk of Parkinson’s disease dementia and a 12 percent higher risk of dementia with Lewy bodies. 

    “This is among the first human epidemiological study to zero-in on a dementia subtype linked to Lewy bodies,” said Xiao Wu, PhD, co-first author of the study and assistant professor of Biostatistics at Columbia University Mailman School of Public Health.

    “The statistical association we uncovered is even stronger than what previous studies found when lumping all Alzheimer’s and related dementias together—highlighting Lewy body formation as a potentially pivotal pathway that warrants deeper biological investigation, says

    “We hope to inspire researchers to conduct both epidemiologic and molecular studies that focus on dementia subtypes linked to Lewy bodies.”

    Exploring the biological reason for this association between exposure to PM2.5 and Lew body dementia, the team of researchers exposed both normal mice and genetically modified mice lacking the alpha-synuclein protein to PM2.5 pollution every other day for a period of ten months. 

    “In normal mice, we saw brain atrophy, cell death, and cognitive decline—symptoms similar to those in Lewy body dementia,” says study collaborator Ted Dawson, MD, PhD, the Leonard and Madlyn Abramson Professor in Neurodegenerative Diseases and director of the Johns Hopkins Institute for Cell Engineering. “But in mice lacking alpha-synuclein, the brain didn’t exhibit any significant changes.”

    The researchers then studied mice with a human gene mutation (hA53T) linked to early-onset Parkinson’s disease. After five months of PM2.5 exposure, these mice developed widespread pockets of alpha-synuclein and experienced cognitive decline. Observed through biophysical and biochemical analysis, these protein clumps were structurally distinct from those that form during natural aging. 

    The team also set out to determine whether air pollution effects varied by location. They found that mice exposed to separate samples of PM2.5 from China, Europe and the United States led to similar brain changes and development of alpha-synuclein pockets, suggesting that the harmful effects of PM2.5 may be broadly consistent across different regions.

    The researchers say changes in gene expression in the brains of PM2.5-exposed mice were strikingly similar to those found in human patients with Lewy body dementia which indicate that pollution may not only trigger the build-up of toxic proteins but also drive disease-related gene expression changes in the human brain. 

    “We believe we’ve identified a core molecular link between PM2.5 exposure and the propagation of Lewy body dementia,” Mao says. 

    While genetic factors play a significant role in neurodegenerative disease, the scientists say people can potentially control their exposure to pollution.  

    The next goal of the researchers is to determine which specific components in air pollution are driving these effects. Understanding that could help guide public health efforts to reduce harmful exposures and lower the risk of disease, notes the research team.

    By identifying this novel strain of Lewy bodies formed after exposure to air pollution the authors of the study hope to establish a specific target for future drugs aimed at slowing the progression of neurodegenerative diseases marked by Lewy bodies.

    Funding:

    The research was supported by the National Institutes of Health (NIH RF1 AG079487, K01 ES036202, P20 AG093975, P30 ES009089, R01 ES030616, R01 AG066793, RF1 AG074372, RF1 AG080948), the Helis Foundation, the Parkinson’s Foundation, the American Parkinson’s Disease Association, the Freedom Together Foundation and the Department of Defense. 

    About this Lewy body dementia research news

    Author: Stephanie Berger
    Source: Columbia University
    Contact: Stephanie Berger – Columbia University
    Image: The image is credited to Neuroscience News

    Original Research: Open access.
    “Lewy body dementia promotion by air pollutants” by Xiaobo Mao et al. Science


    Abstract

    Lewy body dementia promotion by air pollutants

    INTRODUCTION

    Lewy body dementia (LBD), comprising dementia with Lewy bodies (DLB) and Parkinson’s disease (PD) with dementia (PDD), is a devastating and increasingly prevalent neurodegenerative disorder.

    Ambient PM2.5 is a recognized broad dementia risk factor; however, its specific role in initiating LBD, particularly its distinct pathological trajectory versus PD without dementia, remains unaddressed. This study systematically investigates this link.

    RATIONALE

    Pathologic α-synuclein (αSyn) is the defining neuropathological hallmark of LBD. A leading hypothesis posits that environmental neurotoxins, such as fine particulate matter (PM2.5), could trigger initial αSyn misfolding and propagation into the brain. However, epidemiological relationships between PM2.5 exposure and LBD versus PD subtypes lacked large-scale substantiation.

    Whether PM2.5 can induce αSyn to form pathogenic strains that drive LBD’s specific clinical and pathological signatures remains unclear. Elucidating this environmental-molecular nexus is key to unravelling LBD pathogenesis and identifying targeted interventions. Our study aimed to dissect these fundamental mechanisms.

    RESULTS

    Convergent, multimodal evidence from large-scale human epidemiology, molecular, cellular, animal, and patient studies demonstrated a robust PM2.5-LBD link.

    First, analysis of >56 million US Medicare beneficiaries revealed that chronic PM2.5 exposure was significantly associated with first hospitalizations for α-synucleinopathies.

    A key finding was that the link between PM2.5 exposure and hospitalization risk was stronger for LBD (PDD and DLB) patients than for those with PD without dementia, implying a preferential vulnerability or pathogenic mechanism in LBD.

    Second, we demonstrated an essential role of αSyn in PM2.5-related neurological disorders. Chronic PM2.5 exposure in wild-type (WT) mice induced brain atrophy, cognitive deficits, and widespread αSyn pathology in the brain and peripheral organs (gut, lungs) as well as concomitant tau pathology.

    Genetic ablation of αSyn conferred strong protection against these PM2.5-induced detrimental effects, clearly establishing αSyn as an important mediator of this environmental neurotoxicity.

    Third, we found that PM2.5 from diverse global sources (US, China, and Europe) induced conformational change in αSyn preformed fibrils (PFFs), inducing a distinct αSyn strain (PM-PFF). PM-PFF remained stable across passages and, compared with PFF, exhibited LBD-like pathogenic features, including accelerated aggregation, degradation resistance, enhanced propagation, and increased neurotoxicity, mimicking αSyn strains found in LBD.

    When inoculated into humanized αSyn mice, this PM-PFF strain preferentially induced cognitive impairments, contrasting with the primarily motor deficits induced by PFF. Consistently, brain transcriptomic analyses revealed that both chronic PM2.5 exposure and PM-PFF inoculation in humanized αSyn mice elicited gene expression signatures that mirrored those of LBD (PDD and DLB) but not those of PD without dementia, underscoring an LBD-specific pathogenic axis.

    CONCLUSION

    This study provides evidence linking PM2.5 exposure to LBD. The neurotoxic effects of PM2.5 appear to be mediated by αSyn, with exposure generating a pathogenic strain (PM-PFF) that shares key properties with αSyn strains in human LBD.

    In mice, this strain induced cognitive deficits and transcriptomic changes resembling those in LBD patients, distinct from those in PD without dementia. These findings identify an environmental mechanism contributing to LBD pathogenesis and underscores the role of αSyn.

    The PM2.5-induced strain represents a potential target for therapeutic intervention. Collectively, these results emphasize the importance of further research into air pollution’s role in neurodegenerative diseases and its implications for public health strategies.

    Continue Reading

  • Bacteriological Profile and Antimicrobial Resistance Patterns in Neonatal Sepsis: Special Reference to Klebsiella pneumoniae at a Tertiary Care Hospital in Eastern India

    Bacteriological Profile and Antimicrobial Resistance Patterns in Neonatal Sepsis: Special Reference to Klebsiella pneumoniae at a Tertiary Care Hospital in Eastern India


    Continue Reading

  • Bluetongue confirmed in sheep in Cornwall

    Bluetongue confirmed in sheep in Cornwall

    Farmers have been advised to remain vigilant for signs of the bluetongue virus in their animals after a sheep tested positive for the disease.

    The Department for Environment, Farming and Rural Affairs (Defra) confirmed a ram at a property in Cornwall had tested positive for the disease on Friday.

    Defra confirmed the ram had died but other animals on the premises would not be culled since bluetongue virus is mainly spread by biting midges.

    The notifiable disease does not pose a threat to human health or food safety but it can affect farmers by making animals sick, reducing milk yields and affecting breeding, Defra added.

    A Defra spokesperson said: “We have confirmed the detection of bluetongue virus in a single ram at a premises in Cornwall.

    “We urge all animal owners to ensure scrupulous biosecurity standards are in place and to report any signs of infection to the Animal and Plant Health Agency immediately.”

    They said bluetongue affects sheep and other ruminants such as deer and goats as well as camelids such as llamas and alpacas and cattle.

    In the most severe cases, it can cause death in adult animals.

    A restricted zone for bluetongue was put in place across England on 1 July which meant keepers would be able to move their animals without a specific licence or test for the disease.

    Continue Reading