Category: 7. Science

  • Researchers discover new trigger for mitophagy

    Researchers discover new trigger for mitophagy

    Autophagy is essentially the ‘rubbish collection’ of our cells. If there are problems in this process, which is so important for our health, diseases such as Parkinson’s can result. In their latest study, leading cell biologists at the Max Perutz Labs at the University of Vienna investigated mitophagy – a form of autophagy – and came to a remarkable conclusion: the researchers have described a new trigger for mitophagy.

    This discovery has led to a reassessment of the hierarchy of factors that trigger autophagy. The newly discovered signalling pathways could also open up novel therapeutic options. The study has been published in the renowned journal Nature Cell Biology.


    Autophagy is a self-cleaning process of the cell and is crucial for cell health in the human body. A sophisticated molecular surveillance command identifies suspicious substances – broken cell components, clumped proteins or even pathogens – and initiates their removal. Finally, defective cell components are broken down and recycled.

    Mitophagy is a form of autophagy in which mitochondria within a cell are specifically degraded. Dysregulation of mitophagy is particularly associated with Parkinson’s disease. A better understanding of this process is therefore important for combating Parkinson’s.

    In a new study led by postdoctoral researcher Elias Adriaenssens from Sascha Martens’ group at the Max Perutz Labs at the University of Vienna, the scientists reveal a new mechanism for triggering mitophagy. Until now, research has focused heavily on the ‘PINK1/Parkin signalling pathway’. Signalling pathways are used to transmit information within cells. These complex networks of molecules control critical cellular functions such as growth, division, cell death and, indeed, mitophagy.

    “When we looked at the big picture, it became clear that, apart from the much-studied ‘PINK1/Parkin pathway’, there were huge gaps in our knowledge of other mitophagy pathways. Our laboratory has explored these neglected areas by using biochemical reconstitutions to gain fundamental mechanistic insights.”


    Elias Adriaenssens, Study Leader and Postdoctoral Researcher, University of Vienna 

    Newly discovered pathways are no exception

    “We found that NIX and BNIP3 – two known mitophagy receptors – can trigger autophagy without binding to FIP200 (a protein), which was quite unexpected,” explains Adriaenssens.

    FIP200 is considered essential for triggering autophagy. “This presented us with a puzzle. Despite extensive testing, we were unable to detect any interaction between FIP200 and either of the two receptors – which raises the crucial question of how they function without this supposedly crucial component,” he adds.

    However, mass spectrometry revealed that other autophagy components, known as WIPI proteins, bind to these mitochondrial receptors. Since WIPI proteins were previously thought to act later in the signalling pathway, their involvement in triggering autophagy was surprising. Follow-up experiments confirmed these interactions and suggested that WIPI-mediated recruitment is not an exception, but may mediate previously unknown pathways in selective autophagy.

    “This is an exciting discovery – it reveals a parallel trigger for selective autophagy. Instead of a single, universal mechanism, cells appear to use different molecular strategies depending on the receptor and context. Until now, no one has considered WIPI proteins to be key players in triggering autophagosome formation, but our discovery could change that view,” explains Adriaenssens.

     

    Potential for new therapies for Parkinson’s disease

     

    Looking ahead, the study raises an important question: How do cells decide between alternative mitophagy signalling pathways – why do some receptors use one and others the other, and what factors determine which pathway is used? Distinguishing between selective mitophagy signalling pathways could pave the way for therapies that specifically activate one pathway to compensate for defects in the other, which has long-term potential for the treatment of Parkinson’s disease.

    Source:

    Journal references:

    Adriaenssens, E., et al. (2025). Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery. Nature Cell Biology. doi.org/10.1038/s41556-025-01712-y

     

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  • Moon phase today explained: What the moon will look like on July 26, 2025

    Moon phase today explained: What the moon will look like on July 26, 2025

    The moon is becoming a little bit brighter each night as we work through the phases of the lunar cycle.

    The lunar cycle is a series of eight unique phases of the moon’s visibility. The whole cycle takes about 29.5 days, according to NASA, and these different phases happen as the Sun lights up different parts of the moon whilst it orbits Earth. 

    See what’s happening tonight, July 26.

    What is today’s moon phase?

    As of Saturday, July 26, the moon phase is Waxing Crescent. There’s still not much to see tonight, with only 4% of the surface visible to us on Earth (according to NASA’s Daily Moon Observation).

    It’s the second day of the lunar cycle, and with such limited visibility, there’s nothing for you to spot on the moon’s surface tonight, not even with binoculars or a telescope.

    When is the next full moon?

    The next full moon will be on August 9. The last full moon was on July 10.

    What are moon phases?

    According to NASA, moon phases are caused by the 29.5-day cycle of the moon’s orbit, which changes the angles between the Sun, Moon, and Earth. Moon phases are how the moon looks from Earth as it goes around us. We always see the same side of the moon, but how much of it is lit up by the Sun changes depending on where it is in its orbit. This is how we get full moons, half moons, and moons that appear completely invisible. There are eight main moon phases, and they follow a repeating cycle:

    Mashable Light Speed

    New Moon – The moon is between Earth and the sun, so the side we see is dark (in other words, it’s invisible to the eye).

    Waxing Crescent – A small sliver of light appears on the right side (Northern Hemisphere).

    First Quarter – Half of the moon is lit on the right side. It looks like a half-moon.

    Waxing Gibbous – More than half is lit up, but it’s not quite full yet.

    Full Moon – The whole face of the moon is illuminated and fully visible.

    Waning Gibbous – The moon starts losing light on the right side.

    Last Quarter (or Third Quarter) – Another half-moon, but now the left side is lit.

    Waning Crescent – A thin sliver of light remains on the left side before going dark again.

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  • Astronomers reveal a chilling countdown to the end of the universe |

    Astronomers reveal a chilling countdown to the end of the universe |

    For decades, scientists believed the universe would expand forever, driven endlessly outward by a mysterious force known as dark energy. But a new study has upended that view with a provocative idea: the cosmos may one day stop expanding and instead collapse in on itself in a cataclysmic event called the “Big Crunch.” According to the research, which is currently in preprint and awaiting peer review, this reversal could happen in about 20 billion years. Based on new models and fresh astronomical data, scientists are rethinking the fate of everything we know.

    The universe may not expand forever

    The traditional model of the universe’s fate was built on the assumption that dark energy is constant and positive, a force pushing galaxies apart faster over time. But researchers analysing data from the Dark Energy Survey (DES) and the Dark Energy Spectroscopic Instrument (DESI) found evidence that dark energy might not be constant after all. Instead, it could vary over time, as proposed by a new theoretical framework called the axion-dark energy (aDE) model.One of the most striking findings in the new study is the possibility that the cosmological constant — which reflects the energy density of space itself — may be negative. If true, this would mean that gravity could eventually overpower expansion. Over time, this shift would cause the universe’s growth to slow, stop, and then reverse into a contraction phase.

    What is the Big Crunch

    If contraction occurs, all matter and energy could eventually be compressed into a single, dense point — an event known as the Big Crunch. This would be the reverse of the Big Bang. According to the aDE model, the total lifespan of the universe would be about 33.3 billion years, and we are already 13.8 billion years into that span. That leaves approximately 20 billion years before the predicted collapse.

    Not a final verdict yet

    Although the findings are significant, scientists caution that this new model is not confirmed. It is based on observational trends and evolving theoretical physics. Further investigation using next-generation telescopes and deeper space surveys will be needed to determine whether dark energy truly changes over time and whether a cosmic collapse is on the horizon.

    Is the end really the end

    Even if the Big Crunch occurs, it might not mark the permanent end of everything. Some theories propose that a collapsing universe could eventually lead to a rebirth — a new Big Bang triggering a fresh universe cycle. While these ideas remain speculative, the study has opened a bold new chapter in understanding how — and when — our universe might end.


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  • 6 lesser-known octopus facts you probably didn’t know

    6 lesser-known octopus facts you probably didn’t know

    When we think of sea animals, we usually picture dolphins, whales, or sharks. But there’s one sea creature that’s quietly amazing– the octopus. With its soft body, eight bendy arms, and smart behaviour, it’s truly one of a kind.

    Scientists have studied octopuses for years, and the more they learn, the more fascinating these creatures become. Here are some fun and surprising facts that show just how special octopuses really are:


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  • NASA says 20% of workforce to depart space agency – Reuters

    1. NASA says 20% of workforce to depart space agency  Reuters
    2. NASA Goddard Center Director Makenzie Lystrup Set to Depart  NASA (.gov)
    3. Resignations and a ‘dissent’ letter suggest Trump has put NASA’s future in doubt  MSNBC News
    4. The NASA exodus  Politico
    5. Goddard director steps down as tensions at NASA Rise  The Baltimore Banner

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  • Scientists create first artificial cell that moves on its own by chemical reactions

    Scientists create first artificial cell that moves on its own by chemical reactions

    Researchers have created the simplest artificial cell ever—just a membrane, an enzyme, and a mission.

    In a breakthrough that strips life down to its most basic rules, scientists at the Institute for Bioengineering of Catalonia (IBEC) have built a synthetic minimal cell that can move on its own, guided purely by chemistry.

    Just like bacteria that swim toward food or immune cells that race to infection sites, this tiny, lifeless vesicle can sense its environment and navigate through it.

    Chemistry becomes a compass

    The trick lies in a process called chemotaxis, the ability to move along chemical gradients.

    In nature, it’s how sperm find an egg or how white blood cells detect inflammation. But instead of relying on complex biological machinery like flagella or receptors, this artificial cell uses only three parts: a lipid membrane, an enzyme, and a membrane pore.

    Liposomes, the fatty bubbles made from the same molecules as real cell membranes, served as the structural shell. When placed into a gradient of glucose or urea, the enzyme inside the liposome reacts with the molecules, creating an imbalance in concentration.

    This generates fluid flow along the vesicle’s surface, nudging it toward the higher concentration.

    The pore acts like a controlled gateway, creating the asymmetry needed for propulsion like a self-piloting boat powered by molecular currents.

    To prove it worked, the researchers tested more than 10,000 vesicles in microfluidic channels under carefully controlled gradients.

    They found that vesicles with more pores showed stronger chemotactic behavior, while those without pores moved passively toward lower concentrations—likely due to simple diffusion.

    “We rebuild the whole dance with just three things: a fatty shell, one enzyme, and a pore.” said senior author Professor Giuseppe Battaglia, ICREA Research Professor at IBEC. “No fuss. Now the hidden rules jump out. That’s the power of synthetic biology: strip a puzzle down to its bones, and suddenly you see the music in the mess. What once seemed tangled? Pure, elegant chemistry, doing more with less.”

    Nature’s rulebook, rewritten minimally

    In living systems, chemotaxis is a fundamental survival strategy, allowing cells to chase nutrients, avoid danger, and coordinate development.

    Reproducing that behavior with such minimal components gives scientists a model for how life may have first moved in early evolutionary history.

    These findings open the door to engineering synthetic cells for precision drug delivery, environmental sensing, or even programmable self-assembling systems.

    Since the components are all common in biology, scaling up or modifying the system could eventually enable responsive micro-robots built entirely from soft materials.

    “Watch a vesicle move. Really watch it,” Battaglia said. “That tiny bubble holds secrets: how cells whisper to each other, how they ship life’s cargo. But biology’s machinery is noisy, too many parts! So, we cheat.”

    The research was a collaboration between IBEC, the University of Barcelona, University College London, the University of Liverpool, the Biofisika Institute, and the Ikerbasque Foundation for Science. Theoretical support came from José Miguel Rubí’s team at UB, who predicted the vesicles’ chemotactic behavior.

    The study has been published in the journal Science.

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  • In a first, artificial cell moves on its own using just chemistry

    In a first, artificial cell moves on its own using just chemistry

    Researchers have created the simplest artificial cell ever—just a membrane, an enzyme, and a mission.

    In a breakthrough that strips life down to its most basic rules, scientists at the Institute for Bioengineering of Catalonia (IBEC) have built a synthetic minimal cell that can move on its own, guided purely by chemistry.

    Just like bacteria that swim toward food or immune cells that race to infection sites, this tiny, lifeless vesicle can sense its environment and navigate through it.

    Chemistry becomes a compass

    The trick lies in a process called chemotaxis, the ability to move along chemical gradients.

    In nature, it’s how sperm find an egg or how white blood cells detect inflammation. But instead of relying on complex biological machinery like flagella or receptors, this artificial cell uses only three parts: a lipid membrane, an enzyme, and a membrane pore.

    Liposomes, the fatty bubbles made from the same molecules as real cell membranes, served as the structural shell. When placed into a gradient of glucose or urea, the enzyme inside the liposome reacts with the molecules, creating an imbalance in concentration.

    This generates fluid flow along the vesicle’s surface, nudging it toward the higher concentration.

    The pore acts like a controlled gateway, creating the asymmetry needed for propulsion like a self-piloting boat powered by molecular currents.

    To prove it worked, the researchers tested more than 10,000 vesicles in microfluidic channels under carefully controlled gradients.

    They found that vesicles with more pores showed stronger chemotactic behavior, while those without pores moved passively toward lower concentrations—likely due to simple diffusion.

    “We rebuild the whole dance with just three things: a fatty shell, one enzyme, and a pore.” said senior author Professor Giuseppe Battaglia, ICREA Research Professor at IBEC. “No fuss. Now the hidden rules jump out. That’s the power of synthetic biology: strip a puzzle down to its bones, and suddenly you see the music in the mess. What once seemed tangled? Pure, elegant chemistry, doing more with less.”

    Nature’s rulebook, rewritten minimally

    In living systems, chemotaxis is a fundamental survival strategy, allowing cells to chase nutrients, avoid danger, and coordinate development.

    Reproducing that behavior with such minimal components gives scientists a model for how life may have first moved in early evolutionary history.

    These findings open the door to engineering synthetic cells for precision drug delivery, environmental sensing, or even programmable self-assembling systems.

    Since the components are all common in biology, scaling up or modifying the system could eventually enable responsive micro-robots built entirely from soft materials.

    “Watch a vesicle move. Really watch it,” Battaglia said. “That tiny bubble holds secrets: how cells whisper to each other, how they ship life’s cargo. But biology’s machinery is noisy, too many parts! So, we cheat.”

    The research was a collaboration between IBEC, the University of Barcelona, University College London, the University of Liverpool, the Biofisika Institute, and the Ikerbasque Foundation for Science. Theoretical support came from José Miguel Rubí’s team at UB, who predicted the vesicles’ chemotactic behavior.

    The study has been published in the journal Science.

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  • How drought and sea level rise feed on each other

    How drought and sea level rise feed on each other

    Overpumping groundwater, worsening droughts and more rapid evaporation due to higher temperatures have caused a drastic decline in the amount of available freshwater, according to a new study.

    “Continental drying” has redirected the planet’s total water to the oceans to such degree that it has now surpassed melting ice sheets as the biggest contributor to global sea level rise, the research found.

    Losses of land-based water could have profound implications for access to safe drinking water and the ability to grow food in some of the world’s richest agricultural regions.

    “We use a lot of water to grow food,” said Jay Famiglietti, a professor at Arizona State University’s School of Sustainability and one of the authors of the study. “If things don’t change, we’ll see impacts on our food security and just our general water availability.”

    The findings “should be of paramount concern to the general public, to resource managers, and to decision-makers around the world,” the researchers wrote in the study, adding that the identified trends “send perhaps the direst message on the impact of climate change to date.”

    “The continents are drying, freshwater availability is shrinking, and sea level rise is accelerating,” they wrote.

    The study, published Friday in the journal Science Advances, assessed changes in terrestrial water sources, such as lakes, underground aquifers and moisture in soil, over the past two decades. The researchers found that several factors, including climate change, are disrupting Earth’s natural water cycle, upsetting how moisture circulates between the ground, oceans and atmosphere.

    The researchers used data from a suite of four NASA satellites to analyze changes in terrestrial water storage over the past 22 years. The satellites were designed to track the movement of Earth’s water, including changes to the planet’s ice sheets, glaciers and underground reservoirs.

    The researchers found, for instance, that parts of the world that are already dry have been rapidly getting drier since 2014. These drought-ridden regions increased by an area twice the size of California each year, Famiglietti said.

    In several cases, drought-ridden hotspots expanded to create giant, interconnected “mega-drying” regions, according to the study. One such area covers parts of Central America, Mexico, California, the southwestern United States, the lower Colorado River basin and the southern High Plains.

    “The key message here is that water is really a key driver of the changes we see both on land and in the ocean,” said Benjamin Hamlington, a research scientist in the Earth Sciences Section at NASA’s Jet Propulsion Laboratory who served on the science team for the NASA missions that produced the decades of data used in the new study.

    The study found that every large land mass, except for Greenland and Antarctica, has experienced unprecedented drying since 2002.

    Widespread continental drying is expected to have major consequences for people. Three quarters of the world’s population lives in countries where freshwater resources are being depleted, according to the researchers.

    Meanwhile, rising seas threaten to creep up on coastal regions around the globe, making them less habitable and adding to the mounting pressures caused by extreme storms and floods. In the U.S., severe weather has helped trigger an insurance crisis in coastal cities that are prone to extreme weather events.

    The link between sea-level rise and the loss of water locked up in the ground is a consequence of throwing the planet’s water cycle into chaos. Many of these changes, such as overpumping groundwater, are thought to be permanent — or, at the very least, irreversible for thousands or tens of thousands of years, said Alexander Simms, a professor in the Department of Earth Science at the University of California, Santa Barbara, who was not involved with the study.

    “If you pull water off the continents, the only place it has to go is in the ocean,” he said. “Water goes in the atmosphere, then 88% of that water rains down on Earth and ends up in the ocean.”

    Simms said the study was fascinating in its ability to estimate the global scale of these water losses, but he was skeptical of the claim that water loss from the continents has now surpassed ice sheet melt as the biggest contributor to sea level rise.

    Still, Hamlington said the study shows how the movement of water around the planet has enormous ripple effects. It also suggests that the consequences could intensify in the future, if groundwater is further depleted, freshwater resources shrink and drought conditions worsen.

    “This kind of tracking of terrestrial water storage is a critical piece of the puzzle,” he said. “If we can track that water, if we know where it’s going, we can improve our understanding of future drought, flooding and water resource availability over land.”

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  • 5 labs, 2 years, 1 goal: Solving the equations of cancer cell behavior

    5 labs, 2 years, 1 goal: Solving the equations of cancer cell behavior

    Microscopic view of cancer cells: A collaborative effort among Oregon Health & Science University and three other universities has led to the development of mathematical models that may enhance our understanding of how these cells respond to various cancer therapies. This groundbreaking research, published in the journal Cell, aims to pave the way for digital models that can predict cell behavior, revolutionizing treatment strategies for cancer. (Getty)

    A collaboration among Oregon Health & Science University and three other universities has produced mathematical models that could begin to unlock how groups of cells will respond to various cancer therapy combinations.

    Laura Heiser, Ph.D., has short dark hair, black top, and is smiling at Knight Cancer Institute.

    Laura Heiser, Ph.D. (OHSU)

    The findings, published today in the journal Cell, have broad implications across cancer-related specialties, giving researchers the keys to developing digital models designed to test and predict cell behavior.

    “That’s the long-term goal,” said Laura Heiser, Ph.D., vice chair of biomedical engineering, OHSU School of Medicine, and associate director of complex systems modeling in the Cancer Early Detection Advanced Research Center program, OHSU Knight Cancer Institute.

    “This research gives us a tool to begin to predict multicellular behavior. We’re not there yet, but it puts us firmly on the road to being able to identify treatment combinations predicted to work best across cancer types, enabling development of novel treatment strategies.”

    Being able to do this, and do it as soon as possible, is critical for patients with cancer. Customized treatments, also called personalized or precision medicine, deliver better results, fewer side effects and hopes for improving clinical outcomes.

    Young Hwan Chang, Ph.D., has short, wavy dark hair, eye glasses, and a black shirt, sitting at his desk with a computer screen showing data.

    Young Hwan Chang, Ph.D. (OHSU)

    Heiser and Young Hwan Chang, Ph.D., associate professor of biomedical engineering, School of Medicine, and Knight Cancer Institute Interim Director Lisa Coussens, Ph.D., collaborated with researchers from Indiana University, University of Maryland and Johns Hopkins University. In all, four OHSU faculty members and two graduate student trainees took part in the research.

    A Grassroots Effort

    The effort began in 2020, when Heiser and Chang were conducting research into mechanisms of therapeutic resistance in breast cancer and began collaborating with Paul Macklin, Ph.D. A researcher from Indiana University, Macklin is the lead developer of PhysiCell, a software designed to create computational models of cells and tissues.

    Macklin already had ongoing collaborations with Elana Fertig, Ph.D., from University of Maryland, who was focused on pancreatic cancer, and Johns Hopkins University’s Genevieve Stein-O’Brien, Ph.D., who was researching brain development. In other studies, Fertig collaborated with Coussens to understand epigenetic mechanisms impacting therapy response in breast cancer regulated by macrophages, a type of immune cell.

    Thanks to philanthropic and National Institutes of Health funding, the multi-institutional group of scientists began collaborating to harness the various scientific approaches across their five labs.

    For the last two years, they have been meeting every Friday to present their findings and share updates. Their goal? To develop rational rules based on significant biologic responses, which could then inform mathematical prediction models for therapy responses.

    Read more about the Knight Cancer Institute in this media kit.

    For Heiser, the Friday meetings became a highlight of her week.

    “I would really look forward to them,” she says. “I think we all became very invested in the time spent and in the commitment, we had to each other and to developing our ideas.”

    Using validated preclinical biology, the group was able to develop and replicate computational models for cells in multiple types of cancer — a milestone and a moment when the group knew they had a novel approach that could significantly impact patients with cancer.

    “There wasn’t one a-ha moment; there were many. It was a very grassroots effort,” Heiser said. “And we were fortunate to be able to build off of strong research that already existed within OHSU’s biomedical engineering and cancer biology-focused departments and within the Knight Cancer Institute.”

    The group leveraged the following:

    • Twenty years of in vivo breast cancer modeling in the Coussens Lab, which demonstrated that a group of immune cells called macrophages and T cells significantly impact how cancer cells progress into lethal tumors.
    • 2022 research from the Heiser Lab, which developed a detailed map of how breast cells respond to extracellular signals. This helped create a computational model — a test done on a computer instead of in a lab — to better understand how those cells behave.
    • Research from the Chang lab, focused on developing advanced analytics for imaging data.

    The findings open the door for next steps — new research questions that now can be asked and answered with greater accuracy and speed.

    Lisa Coussens, Ph.D., has shoulder-length blonde hair, eyeglasses, and a beige sweater, smiling.

    Lisa Coussens, Ph.D. (Courtesy)

    “The collaboration and team-science approach provides a foundational platform to predict the effects of various cell types embedded within tumors expressing different therapeutic targets, based on biological findings, without having to do 20 years’ worth of in vivo biological studies,” Coussens said.

    For Heiser and the entire group, working together from a multidisciplinary standpoint has been not only effective, but gratifying.

    “We really need a multidisciplinary view if we’re going to cure cancer,” Heiser said. “Our ultimate goal is always to improve outcomes for patients, and to do that, we have to tackle these questions from many different angles.

    “It’s a multifaceted disease, so it makes sense that the approach needs to be multifaceted as well. We have been able to demonstrate that the work we’ve been doing these past several years and over these many Fridays has yielded something that can be useful to the broader cancer research community, and that is really very meaningful.”

    Research reported in this publication was supported by the Jayne Koskinas Ted Giovanis Foundation for Health and Policy, the National Foundation for Cancer Research and the Susan G Komen Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the various foundations.

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  • In 90 seconds, AI satellite thinks, tilts, and shoots without human help

    In 90 seconds, AI satellite thinks, tilts, and shoots without human help

    In a first, a satellite used AI to spot, think, and act in under 90 seconds, without human help.

    The breakthrough came during a recent NASA test of a new technology called Dynamic Targeting, which equips orbiting spacecraft with the ability to autonomously analyze their surroundings and decide, on the fly, where to collect scientific data.

    The system allows satellites to look ahead along their orbital path, detect what’s worth observing, like a clear sky or a natural disaster, and point their instruments accordingly.

    Smarter skies, sharper science

    Developed over a decade at NASA’s Jet Propulsion Laboratory, Dynamic Targeting mimics how a human might interpret imagery.

    Instead of simply capturing whatever lies below, the AI processes visual data in real time, identifies meaningful features like clouds or fires, and then chooses whether or not to snap a picture. The recent test completed this entire sequence in under a minute and a half.

    This ability to think ahead is especially valuable for Earth-observing satellites, which often struggle with one stubborn obstacle: clouds.

    Optical sensors can’t see through them, yet satellites traditionally image whatever is beneath them anyway, cloudy or not, wasting time, storage, and bandwidth on data that scientists can’t use.

    With Dynamic Targeting, the spacecraft analyzes look-ahead imagery to detect cloud cover up to 300 miles in advance. If the sky is clear, it captures the surface. If clouds are in the way, it skips the shot and saves its resources for a better opportunity.

    “Instead of just seeing data, it’s thinking about what the data shows and how to respond,” said Steve Chien, AI technical fellow at JPL and lead on the project.

    “When a human sees a picture of trees burning, they understand it may indicate a forest fire, not just a collection of red and orange pixels. We’re trying to make the spacecraft have the ability to say, ‘That’s a fire,’ and then focus its sensors on the fire.”

    Speed, precision, and time

    The tech was put to the test aboard CogniSAT-6, a briefcase-sized CubeSat launched in March 2024 and built by UK-based Open Cosmos. To simulate a forward-looking imager, the satellite physically tilted itself 40 to 50 degrees to peer ahead along its orbit.

    Once it collected the preview image, onboard algorithms processed it to locate cloud-free regions.

    The spacecraft then shifted back to a straight-down position and captured only the clear, usable views.

    And it did all this at nearly 17,000 mph.

    Now that the system has successfully avoided clouds, NASA’s next tests will flip the script, targeting clouds instead.

    Dynamic Targeting will be used to seek out fast-forming, short-lived weather phenomena such as deep convective ice storms, which are notoriously difficult to observe using traditional satellite scheduling.

    Specialized algorithms will identify telltale storm structures, and a powerful radar will then “stare” at the storm as the satellite races overhead, collecting high-resolution data for several minutes.

    Other tests will involve searching for thermal anomalies, including wildfires and volcanic eruptions.

    These events often evolve rapidly, leaving a narrow window to observe them. Dynamic Targeting’s rapid decision-making makes it ideally suited to spot these changes in real time and act before the moment is lost.

    Each new application involves training unique algorithms to identify specific visual or thermal patterns, a growing suite of onboard intelligence that makes the spacecraft more responsive and mission-adaptable.

    The long-term vision extends well beyond Earth.

    NASA is exploring how Dynamic Targeting could aid planetary science missions, like spotting geysers on icy moons, detecting plumes on comets, or focusing on shifting dust storms on Mars.

    In fact, the original concept was partly inspired by research done using ESA’s Rosetta orbiter, where similar AI methods helped detect and image plumes erupting from Comet 67P.

    There’s even a plan in the works to expand this concept across satellite constellations. In a project called Federated Autonomous Measurement, a leading satellite could detect an event and instantly relay that data to trailing satellites.

    The following spacecraft would then reorient and focus on the phenomenon, building a coordinated and dynamic response system in orbit.

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