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  • California affirms vaccine advice after US govt autism change – Medical Xpress

    1. California affirms vaccine advice after US govt autism change  Medical Xpress
    2. CDC in turmoil after agency backpedals on rejecting vaccines-autism link  The Washington Post
    3. Leading Autism and Disability Organizations Statement on CDC’s Vaccines and…

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  • Rethinking AI’s impact on future of work

    Rethinking AI’s impact on future of work

    1. What’s a conversation we’re not having enough when it comes to AI and the future of work? 

    There is no shortage of headlines and articles on AI and the future of work. But too often, this discourse focuses solely on job losses, coupled with sensational headlines. While technologies continue to evolve rapidly, meaning that we can’t yet drew firm conclusions, it is also true that we need to look at the labour market effects much more carefully. This entails understanding how AI impacts not only the quantity of jobs but also the quality of them and the nature of work, in terms of wages, working conditions and rights more broadly. The larger issue of inequality is also crucial.  

     

    2. In your view, what are the current and potential future impacts of automation on developing economies? 

    Currently, the impact of digitalization and AI in developing economies is less than in advanced economies, primarily due to the digital divide and differences in the structure of economies. While the possible negative effects on jobs are less (but not zero), we also know, as shown by ILO research, that the digital divide prevents developing countries from taking advantage of the benefits from new technologies, such as AI.  

    But there are two caveats to this view that developing countries are not being affected by AI. First, digital tools and platforms are growing rapidly, even if the use of generative AI is more confined to small part of the population – see the rise of digital payment systems, such as M-PESA in Eastern Africa, and the rapid emergence of digital labour platforms, both location-based and online, which are creating opportunities and challenges in all countries. Second, emerging technologies, such as AI, continue to evolve so we cannot assume that the situation today will hold in the coming months and years. We need to continue to monitor the situation.  



    © International Monetary Fund Flickr

    Residents use M-pesa services at a local kiosk in Kibera slum, Nairobi, Kenya

    3. How do these impacts influence groups in vulnerable situations, such as women, youth, and migrants? 

    A key lesson from centuries of technological change is that there are both winners and losers as economies and labour markets adjust. ILO research has shown that women are more susceptible to the automation effects of AI due to their overrepresentation in occupations that are most exposed, such as administrative jobs. Recent data on actual labour market trends (as opposed to potential effects) is telling us that we should be worried about how generative AI is impacting young people – evidence is emerging to suggest that there is a more negative effect of AI on young labour market entrants in such countries as the US. At the same time, there are range of use cases that can help certain groups access new learning and employment opportunities. For example, under the  PROSPECTS programme, the ILO is supporting young people in remote areas of Kenya through digital skills training and mentoring programmes to access online job opportunities. 

     

    4. While we talk about the quantity of jobs impacted by AI, what would you say about the quality of jobs impacted? 

    As already mentioned, we need to focus on not only implications of AI for job quantity but quality as well, which is where the largest effects are likely to emerge. AI impacts tasks and won’t eliminate most jobs entirely. But these changes can lead to effects on wages, depending on how demand for the occupation shifts, and working conditions due to the impact of AI in the workplace.  

    We already see the use of algorithmic management tools, which are getting supercharged by AI, for recruitment, allocating tasks, monitoring and evaluating workers. While this has the potential to improve productivity, it poses challenges in terms of workers’ agency and the nature of their jobs. Key is transparency on the use of these tools, matched by dialogue to ensure that new technologies can be beneficial to both the enterprise and their workers.  

     

    5. There’s often a regional divide in how AI is deployed and its benefits are distributed. How can we bridge that gap—both nationally and globally? 

    A digital divide exists both within and between countries due to differences in access to digital infrastructure and skills. The share of the population using the Internet in 2024 reached 93 per cent in high-income countries compared with just 27 per cent of the population in low-income economies. Even in advanced economies, such as in the European Union, access to AI is uneven with higher rates of adoption in richer countries and larger firms. Within countries, access to broadband (optic fibre) Internet and training programmes is more limited in rural areas. In response, greater investments are needed in infrastructure and skilling to ensure that these gaps are reduced. Support is also needed to ensure that there are opportunities for developing economies to build their own AI ecosystems in terms of both development and deployment of new technologies in different languages and adapted to country-specific contexts.   

    The share of the population using the Internet in 2024 reached 93 per cent in high-income countries compared with just 27 per cent of the population in low-income economies.

    6. What kind of policy frameworks do we need to ensure that AI benefits all workers? 

    From an ILO perspective, the Decent Work Agenda remains key for assessing both the benefits and challenges arising from the development and deployment of AI. In practice, responding to the opportunities and challenges posed by AI will involve applying existing policies and regulations, while adapting and developing new strategies and governance frameworks where needed, in line with international labour standards and through social dialogue (e.g., to address the platform economy).  

    There are three areas we need to look at: first, address the negative impact of AI through redeployment, social protection and active labour market policies (e.g., employment services); second, enhance digital skilling and upskilling to support access to new technologies, along with measures to assist small businesses to overcome the digital divide and take advantage of opportunities; and third, strengthen governance mechanisms to ensure rights are protected in the workplace (e.g., safeguarding against discriminatory algorithms). 

     

    7. If you could deliver just one message to global policymakers about AI and employment, what would it be? 

    AI is creating both new opportunities and challenges in the world of work and to ensure that the benefits are broadly shared, we need to assess the impact of AI on both the quality and quantity of jobs, and respond through employment policies and other measures, backed by the latest evidence and social dialogue.  

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  • New MOF binds two gas molecules at each metal site | Research

    New MOF binds two gas molecules at each metal site | Research

    A new metal–organic framework (MOF) selectively adsorbs two molecules of carbon monoxide at each metal site. The US-based researchers that developed it believe that the underlying chemistry may enable the design of MOFs that capture other gases…

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  • Procyclicality and leverage of euro area UCITS hedge funds: an unhealthy mix

    Procyclicality and leverage of euro area UCITS hedge funds: an unhealthy mix

    Prepared by Paolo Alberto Baudino, Oscar Schwartz Blicke and Maurizio Michael Habib

    Published as part of the Financial Stability Review, November 2025.

    Hedge funds represent a relatively small segment of the euro area investment fund sector and comprise both AIF and UCITS hedge funds. The total assets of euro area hedge funds stood at around €660 billion in the third quarter of 2025, equivalent to roughly 3% of the investment fund sector’s total assets. In the EU, hedge funds may fall either under the Alternative Investment Fund Managers Directive (AIFMD)[1] or the Undertakings for Collective Investment in Transferable Securities (UCITS) Directive.[2] AIF hedge funds are usually marketed to wealthy investors and are predominantly held by euro area investment funds. They offer limited liquidity, by allowing redemptions only quarterly or even annually (often with advance notice), for example, and by imposing lock-up periods on initial investments. By contrast, UCITS hedge funds are more accessible to retail investors and other non-bank sectors – with euro area households and insurance corporations each holding around 15% of the shares in such funds. As these funds often allow investors to redeem shares on a high-frequency basis, the sector is more exposed to fund share redemptions during market turmoil. UCITS hedge funds account for about 30% of the overall hedge fund sector in terms of shares issued (Chart A, panel a) as well as total assets.

    Chart A

    UCITS hedge funds exhibit higher retail participation and use derivatives more intensively than do AIF hedge funds

    a) Investor base and shares issued by euro area hedge funds, by fund type

    b) Euro area hedge funds’ financial leverage and gross derivatives exposure, by fund type

    c) Gross derivatives exposures of euro area UCITS hedge funds and derivative type distribution

    (Q3 2025; percentages, € billions)

    (Q3 2025; total assets divided by shares issued, derivative gross notional divided by shares issued)

    (Q3 2025, derivative gross notional divided by shares issued)

    Sources: ECB (EMIR, IVF, SHS), Morningstar Direct[3] and ECB calculations.
    Notes: the sample of euro area UCITS and AIF hedge funds is derived from the ECB’s investment fund list classification. AIF stands for alternative investment fund. Panel a: the investor base is proxied by information available for traded securities. The latest available information on the investor base refers to Q2 2025. For a discussion of different measures of leverage for hedge funds, see the article entitled “Leveraged investment funds: A framework for assessing risks and designing policies”, Macroprudential Bulletin, Issue 26, ECB, 2025. Panel c: hedge fund strategies follow the Morningstar Direct classification. HFs stands for hedge funds.

    As UCITS hedge funds have relatively high derivatives exposure and leverage, they warrant attention from a financial stability perspective. Both UCITS and AIF hedge funds employ a wide range of investment strategies, including leveraged trades, to achieve positive absolute returns. Because of regulatory constraints on borrowings,[4] UCITS hedge funds make less use of financial leverage than AIF hedge funds do, with a total assets/equity ratio of 1.3 for UCITS hedge funds versus 1.7 for AIF hedge funds. However, synthetic leverage through derivatives is more pronounced in UCITS hedge funds, with gross notional derivatives exposure reaching up to 12 times equity for fund categories such as global macro strategies (Chart A, panels b and c).[5] In addition, UCITS hedge funds hold a lower proportion of highly liquid assets (e.g. cash and sovereign bonds) than AIF hedge funds do.[6] This leaves them more vulnerable to liquidity risk from redemption shocks or margin calls. Although some research has been carried out on the performance of UCITS hedge funds, this box sheds light on their liquidity and leverage-related risks, given their importance for financial stability.[7]

    Procyclical flows and larger redemptions from leveraged funds in times of stress can lead to asset sales and mounting liquidity pressures during periods of high market volatility. Evidence from a panel of 457 UCITS hedge funds shows that their flows are procyclical, positively correlated with past returns (Chart B, panel a) and in line with the findings for other fund categories.[8] Although the analysis does not indicate that leverage generally amplifies the flow procyclicality of UCITS hedge funds, it does show larger outflows from leveraged UCITS hedge funds in periods of market stress (Chart B, panel b). Since fund share redemptions may force funds to sell assets when markets are under pressure, leveraged funds could be required to close larger positions, thereby amplifying stress.

    The use of derivatives by UCITS hedge funds can intensify liquidity pressures via margin calls. Derivatives positions, which can be used for hedging or for leverage, are subject to margin requirements. During periods of elevated price volatility and significantly negative returns, margin calls on these derivatives positions tend to increase (Chart B, panel c), further straining a fund’s liquidity.[9] This exacerbates the challenges faced by leveraged UCITS hedge funds, as they have to manage liquidity to meet both margin calls and redemption requests simultaneously. Interaction between these factors can heighten liquidity strains and contribute to broader market stress under adverse market conditions.[10]

    Chart B

    Flows into UCITS hedge funds tend to be procyclical, while margin calls may intensify liquidity risk

    a) Average fund-level flows into euro area UCITS hedge funds, by lagged return level

    b) Average fund-level flows into euro area UCITS hedge funds, by synthetic gross leverage level

    c) Average fund-level daily posted variation margin of euro area UCITS hedge funds, by negative return level

    (Jan. 2019-Oct. 2025; standardised values, percentages)

    (Jan. 2019-Oct. 2025; standardised values, log of derivative gross notional as a percentage of TNA)

    (Jan. 2020-Oct. 2025; percentages of TNA, percentages)

    Sources: ECB (EMIR), EPFR Global, Morningstar Direct[11] and ECB calculations.
    Notes: Panel a: the sample is based on funds that have been classified as UCITS hedge funds in the ECB’s investment fund list since 2009, to limit survivorship bias. The analysis is restricted to funds pursuing major hedge fund-like strategies, as classified by Morningstar Direct, and which have substantial representation in the sample. These strategies include global macro, systematic trend, options trading, market neutral and long/short strategies. Fund-level returns are calculated by aggregating the returns for each fund’s share classes, weighted by the total net assets (TNA) of each share class. Fund-level flows and TNA are obtained by aggregating the corresponding values across all the share classes within each fund. Flows are expressed as percentages of TNA and standardised to remove trends from the data. Panel b: stress episodes are defined as months in which the VIX exceeds the 90th percentile of our sample. Synthetic leverage is proxied by the gross notional value of derivatives excluding interest rate and FX contracts, which are extensively used for hedging, as a share of fund-level TNA. Panel c: average posted variation margin (VM) is calculated as the mean of fund-level daily margin amounts posted as percentages of fund TNA.

    A robust stress-testing framework for leveraged UCITS hedge funds is essential to ensure their resilience and limit the risks to financial stability in turbulent market conditions. The combination of outflows and margin calls on derivatives positions can intensify liquidity pressures for UCITS hedge funds during periods of stress. This raises concerns about the ability of such funds to manage the challenges and contributes to broader financial instability. These dynamics highlight the need for strengthened risk management and comprehensive stress-testing practices to safeguard financial stability during episodes of market turmoil.

    Finally, authorities should be equipped with suitable tools to limit excessive leverage in UCITS hedge funds and mitigate the build-up of risks during periods of market stress. While authorities have tools that enable them to contain excessive leverage in AIFMD-compliant funds, they do not have such tools for UCITS hedge funds. The Eurosystem suggests introducing discretionary powers that would allow authorities to impose stricter leverage limits on these funds when they pose risks to financial stability.[12] It also recommends that all UCITS hedge funds should be required to report their leverage using the commitment approach.

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  • Revised Milk OIT Reduces Severe Gastrointestinal Reactions

    Revised Milk OIT Reduces Severe Gastrointestinal Reactions

    A NEW retrospective study suggests that a revised protocol for milk oral immunotherapy (OIT) may significantly reduce the severity of a troubling gastrointestinal side effect known as OIT-induced gastrointestinal eosinophilic reactions…

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  • business models and financial stability implications

    business models and financial stability implications

    Prepared by Maciej Grodzicki, Urtė Kalinauskaitė, Benjamin Klaus, Chloe Larkou, Francesca Lenoci and Allegra Pietsch

    Published as part of the Financial Stability Review, November 2025.

    The US dollar assets and liabilities of euro area banks arise mainly from their capital market activities. Capital market activities are often characterised by short maturities and require daily marking to market and margining. These features may pose a liquidity risk to banks in the event of abrupt market movements. US dollar funding and hedging instruments provided by banks are also important for euro area corporates and non-bank financial institutions, especially when exchange rates move rapidly. This box presents the business rationale for euro area banks’ US dollar activities and aims to assess the associated financial stability risks.

    US dollar activities are concentrated among euro area global systemically important banks (G-SIBs), which intermediate US dollars to other European parties. In contrast to other major currencies, US dollar activities relate almost exclusively to wholesale business.[1] The breakdown of euro area banks’ US dollar assets and liabilities reveals the high weight of capital market activities relative to loans and deposits from the non-financial sector (Chart A, panel a). Other financial assets and liabilities, which include primarily the positive fair value of derivatives, are the largest balance sheet position denominated in US dollars. They are followed by repo borrowing, debt securities funding, holdings of debt securities and deposits taken from banks and other financial institutions.

    Banks’ dollar-denominated credit exposures are largely limited to holding high-quality debt securities and lending to the non-financial corporate sector. Euro area banks’ debt securities holdings denominated in US dollars consist mainly of US Treasuries and agency mortgage-backed securities, followed by debt issued by non-US governments and financial institutions. These securities qualify as high-quality liquid assets. Euro area banks’ dollar-denominated lending is estimated to be close to €700 billion at the least (9.2% of the total loan book), with most of this going to non-euro area corporate and non-bank financial clients (Chart A, panel b).[2]

    Chart A

    Capital markets business dominates in euro area banks’ US dollar activities

    a) Dollar-denominated assets and liabilities of 48 euro area significant institutions, by bank type

    b) Dollar-denominated securities holdings and bank lending of euro area banks

    (Q4 2024, € trillions)

    (Q4 2024, percentages)

    Source: ECB (supervisory data, SHS, AnaCredit) and ECB calculations.
    Notes: Panel a: based on annual funding plan reports by 48 banks, including five global systemically important banks (G-SIBs), for which US dollar-denominated liabilities account for over 5% of their total liabilities. The share of these banks in the total assets of significant institutions supervised by the ECB amounts to 56%. The data on repos use the liquidity coverage ratio template and capture only transactions with a residual maturity up to 30 days, while the data on reverse repo lending to financials use the net stable funding ratio template. “Other financial assets/liabilities” mainly includes trading assets and liabilities such as derivatives, equity and fund shares, and repo borrowing with a residual maturity of more than 30 days. “Other banks” includes, among others, euro area subsidiaries of US banking groups. Panel b: covers all euro area significant institutions, meaning numbers are larger than in panel a. Data exclude subsidiaries of non-euro area banks in the euro area and loans held in the foreign subsidiaries of euro area banking groups. The debt of supranational issuers is included in non-US non-euro area sovereign debt. Lending data are based on the AnaCredit dataset and exclude retail loans to households, loans to banks, reverse repo transactions and intragroup exposures. EA stands for euro area. “Non-banks” refers to non-bank financial intermediation entities.

    The US dollar activities of euro area banks in capital markets represent a diverse set of financial services to the economy. Euro area banks, especially some of the G-SIBs, are present in US money markets, where they act as intermediaries by sourcing funding from money market funds and lending the proceeds to hedge funds on a secured basis.[3] Euro area investment funds, life insurers and pension funds invest in dollar-denominated assets, despite their euro-denominated obligations to fund-shareholders or policyholders. Euro area banks facilitate these counterparties’ needs to mitigate the resulting currency risk by engaging in FX swaps, effectively receiving US dollars and paying euro to investment funds, insurance corporations and pension funds. Euro area banks partially hedge this currency risk by taking opposite positions with global banks (Chart B, panel a). These US dollar liabilities are not visible on bank balance sheets.[4] Euro area banks also provide currency hedges to euro area exporters and importers, although such hedging trades are on a smaller scale than those associated with euro area financial investors. For instance, as of July 2025, banks are facilitating US dollar payments to non-financial corporations via currency swaps, primarily to stabilise such corporations’ import costs rather than to manage dollar-denominated revenue flows.

    While asset-liability mismatch appears to be limited in extent, banks are nonetheless taking liquidity risk due to mismatches between counterparties providing and receiving funding. Some banks mitigate liquidity risks further by running maturity-matched repo books and do not use volatile short-term repos to fund illiquid long-term assets. However, these strategies do not fully eliminate liquidity risk. While banks hold sizeable quantities of high-quality liquid assets, dollar outflows in an extreme scenario could exhaust their capacity to raise cash through repos, FX swaps and the sale of such assets.[5] The value of liquid assets may also decline in these circumstances, exacerbating liquidity pressures.[6] Although net outflows of US dollars could be covered by US dollar liquid assets in the long term, the net outflows are concentrated in the short term. Some banks may require additional funding in US dollars or rely on inflows of US dollars from maturing short-term assets to remain liquid during financial stress (Chart B, panel b). However, collecting these cash inflows would imply that they reduce US dollar funding to counterparties.

    Chart B

    Euro area banks’ US dollar intermediation activities

    a) Euro area banks’ net dollar-denominated FX swap and CIRS positions

    b) Cumulative contractual gap between US dollar inflows and outflows to/from euro area banks

    (Q2 2025, € billions)

    (Q4 2024, percentages of US dollar HQLA)

    Source: ECB (EMIR, sector enrichment based on Lenoci and Letizia*, supervisory data) and ECB calculations.
    Notes: Panel a: foreign exchange (FX) swap and cross-currency interest rate swap (CIRS) positions of euro area banks with other counterparties, netted within maturity bucket. Within the same maturity bucket, euro area banks’ derivatives positions with the same counterparty sector are netted against each other. A positive net position indicates that the euro area banks are committed to receiving US dollars and paying euro with a specific time bucket. “Banks” includes net derivatives positions with banks that are not supervised by the ECB. NFCs stands for non-financial corporations; IFs stands for investment funds, including money market mutual funds; ICPFs stands for insurance corporations and pension funds; OFIs stands for other financial intermediaries. Panel b: the periods denote the residual maturity of the contractual inflows and outflows. The net contractual gap is calculated as the sum of the net contractual outflows (gross inflows less gross outflows) scheduled over a given horizon and presented as a share of dollar-denominated HQLA. G-SIBs stands for global systemically important banks; IWBs stands for investment and wholesale banks; UDIs stands for universal and diversified institutions, which include universal banks and diversified lenders; HQLA stands for high-quality liquid assets.
    *) See Lenoci, F.D. and Letizia, E., “Classifying Counterparty Sector in EMIR Data”, in Consoli, S., Reforgiato Recupero, D. and Saisana, M. (eds.), Data Science for Economics and Finance, Springer, Cham, 2021.

    Maintaining adequate balance sheet capacity is necessary to enable banks to act as shock absorbers. If euro area banks reduce their dollar intermediation, their counterparties could face difficulties funding or hedging dollar-denominated investments and may need to sell such assets. Capital and US dollar liquidity buffers provide the balance sheet space required by banks to offer financial services in US dollars to their counterparties in times of financial stress. Capital headroom could be needed to absorb the increase in capital requirements associated with higher currency volatility and counterparty credit risk. Although liquidity risk may not materialise in banks’ own balance sheets and there is no regulatory requirement for banks to match the currencies of liquid assets to the currencies of liabilities, banks should hold liquid US dollar assets to counterbalance outflows and act as a stabilising intermediary.

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  • Jupiter passes south of Pollux

    Jupiter passes south of Pollux

    Jupiter passes due south of Pollux in Gemini today. This evening, watch the Galilean moon Io disappear into the gas giant’s shadow.

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  • ‘Too nice’ Pep Guardiola takes full blame for Man City’s Champions League loss to Bayer Leverkusen after ‘first time in my life’ selection gamble

    ‘Too nice’ Pep Guardiola takes full blame for Man City’s Champions League loss to Bayer Leverkusen after ‘first time in my life’ selection gamble

    Speaking to reporters after the match, Guardiola said: “I take full responsibility. Too many changes. I always had the belief it’s a long season and everyone has to be involved but maybe it was too much. It was the first time in my life I’ve…

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  • ITV Developing ‘Let’s Play Ball’ From ‘Last One Laughing’ Producers

    ITV Developing ‘Let’s Play Ball’ From ‘Last One Laughing’ Producers

    EXCLUSIVE: Could famous comedians be about to play some ball on ITV?

    Deadline understands ITV has put in early development a version of Dutch format Let’s Play Ball, in which rival teams of comedians go head-to-head in a race…

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  • The Ashes 2025: Will rest of Australia-England be played on fast forward after two-day Perth Test?

    The Ashes 2025: Will rest of Australia-England be played on fast forward after two-day Perth Test?

    There was a time in the middle of the previous decade when Australian pitches offered next to no encouragement for bowlers.

    On England’s Ashes tour of 2017-18, the fourth Test in Melbourne yielded more than 1,000 runs for only 24 wickets. The…

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