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  • Webb Telescope maps dark matter in the Bullet Cluster

    Webb Telescope maps dark matter in the Bullet Cluster

    The aptly-named Bullet Cluster is a huge structure in deep space that formed from the merging of two massive galaxy clusters 3.8 billion lightyears away.

    Now the James Webb Space Telescope has given scientists the clearest, most detailed look yet at the chaotic aftermath, including the location of the elusive dark matter hiding within it.

    NASA, ESA, CSA, STScI, processed by Joseph DePasquale (STScI)

    Solving just what dark matter is made of is one of the biggest goals in physics right now.

    And Webb has given scientists an insight into how it’s distributed across this enormous region of space.

    A crash course in cosmic cartography

    The Bullet Cluster is not just two galaxy clusters colliding in slow-motion over billions of years, it’s also a physics lab for studying dark matter.

    Dark matter is a mysterious substance that doesn’t emit or reflect light, but makes up most of the Universe’s mass.

    Astronomers know it’s there because it’s the only way to account for the gravitational pull that’s holding galaxies together.

    Counting up all the mass of visible matter in galaxies alone – stars, dust and gas – doesn’t reveal enough ‘stuff’ that could prevent a galaxy’s stars from flying outwards into space as the galaxy rotates.

    There must be some extra, unseen matter holding the galaxy’s structure together. That unseens substance is known as ‘dark matter’.

    A team of astronomers led by PhD student Sangjun Cha of Yonsei University have used Webb’s near-infrared vision to weigh and map the mass of the Bullet Cluster more accurately than ever before.

    Their study, published in The Astrophysical Journal Letters, includes the most comprehensive gravitational lensing dataset of this region to date.

    The central region of the Bullet Cluster, made up of two massive galaxy clusters. Galaxies and stars were captured by the James Webb Space Telescope. Hot X-rays captured by the Chandra X-ray Observatory appear in pink. Blue represents the dark matter, which was mapped by scientists using Webb’s imaging. Credit: NASA, ESA, CSA, STScI, CXC. Science: James Jee (Yonsei University, UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (Caltech/IPAC)
    The central region of the Bullet Cluster, made up of two massive galaxy clusters. Galaxies and stars were captured by the James Webb Space Telescope. Hot X-rays captured by the Chandra X-ray Observatory appear in pink. Blue represents the dark matter, which was mapped by scientists using Webb’s imaging. Credit: NASA, ESA, CSA, STScI, CXC. Science: James Jee (Yonsei University, UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (Caltech/IPAC)

    Seeing the invisible

    We can’t directly see dark matter, but we can see its effects.

    That’s where gravitational lensing comes in, a trick where massive objects like galaxy clusters bend and magnify the light from background galaxies.

    It’s like watching light ripple across a pond, except in this case, the ripples are caused by dark matter warping spacetime.

    “With Webb’s observations, we carefully measured the mass of the Bullet Cluster with the largest lensing dataset to date, from the galaxy clusters’ cores all the way out to their outskirts,” says Sangjun Cha.

    “Webb’s images dramatically improve what we can measure in this scene, including pinpointing the position of invisible particles known as dark matter,” says Kyle Finner, a study co-author and an assistant scientist at IPAC at Caltech in Pasadena, California.

    James Webb Space Telescope's near-infrared image of the Bullet Cluster. Credit: NASA/ESA/CSA/STScI; Image processing: NASA/STScI/J. DePasquale
    James Webb Space Telescope’s near-infrared image of the Bullet Cluster. Credit: NASA/ESA/CSA/STScI; Image processing: NASA/STScI/J. DePasquale

    Tracing the stars between galaxies

    The team measured thousands of galaxies in Webb’s images to accurately ‘weigh’ visible and invisible mass in the galaxy clusters.

    And they mapped and measured the light emitted by stars no longer bound to individual galaxies, known as intracluster stars.

    Their findings are persuasive:. “We confirmed that the intracluster light can be a reliable tracer of dark matter, even in a highly dynamic environment like the Bullet Cluster,” Cha says.

    What’s more, if these stars are bound to cluster’s dark matter, the team say it could get easier to refine what they know about dark matter.

    In the new map of the Bullet Cluster, an image from Webb’s NIRCam (Near-Infrared Camera) is overlaid with data from NASA’s Chandra X-ray Observatory.

    It shows hot gas in pink, including the bullet shape on the right side of the image.

    Refined measurements of the dark matter, calculated by the team using Webb, are shown in blue.

    Viewed as a whole, the new measurements refine the map of mass spread across the Bullet Cluster.

    And this is revealing the history of the clusters involved in the merger.

    For example, the galaxy cluster on the left of the image has an asymmetric, elongated area of mass along the left edge of the blue region.

    This, say the team, is a clue pointing to previous mergers in that cluster.

    The central region of the Bullet Cluster, made up of two massive galaxy clusters. The two individual galaxy clusters are circled. Credit: NASA, ESA, CSA, STScI, CXC. Science: James Jee (Yonsei University, UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (Caltech/IPAC)
    The central region of the Bullet Cluster, made up of two massive galaxy clusters. The two individual galaxy clusters are circled. Credit: NASA, ESA, CSA, STScI, CXC. Science: James Jee (Yonsei University, UC Davis), Sangjun Cha (Yonsei University), Kyle Finner (Caltech/IPAC)

    A dark, mysterious giant

    The team’s study shows that dark matter isn’t just invisible, it’s eerily quiet.

    Their observations confirm it doesn’t interact much, if at all, with itself. Or, as the study puts it: “dark matter shows no signs of significant self-interaction”.

    “As the galaxy clusters collided, their gas was dragged out and left behind, which the X-rays confirm,” Finner says.

    Webb’s observations show dark matter still lines up with the galaxies, and wasn’t dragged away.

    X-rays from the Bullet Cluster captured by the Chandra X-ray Observatory. Credit: NASA/CXC/SAO. Image processing: NASA/STScI/J. DePasquale
    X-rays from the Bullet Cluster captured by the Chandra X-ray Observatory. Credit: NASA/CXC/SAO. Image processing: NASA/STScI/J. DePasquale

    The bullet that shot twice

    The dark matter map also suggests the Bullet Cluster may have gone through more than one dramatic collision.

    That mass clump on the left could be the fingerprint of an earlier, or later, collision involving the larger cluster.

    “A more complicated scenario would lead to a huge asymmetric elongation like we see on the left,” says James Jee, co-author and professor at Yonsei University.

    What’s next?

    The team say they’ve only uncovered part of the story.

    “It’s like looking at the head of a giant,” says Jee. “Webb’s initial images allow us to extrapolate how heavy the whole ‘giant’ is, but we’ll need future observations of the giant’s whole ‘body’ for precise measurements.”

    Enter the Nancy Grace Roman Space Telescope, scheduled to launch by May 2027, which will also give researchers expansive near-infrared images of the Universe.

    “From NASA’s Nancy Grace Roman Space Telescope, which is set to launch by May 2027. “”With Roman, we will have complete mass estimates of the entire Bullet Cluster, which would allow us to recreate the actual collision on computers,” Finner says.

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  • Clarity supports Orbitus in document management system upgrade

    Clarity supports Orbitus in document management system upgrade

    Orbitus has developed its digital infrastructure with the introduction of a new document management system – M-Files and Hubshare, implemented in partnership with Guernsey-based Clarity.

    The new system enhances the creation and management of documents as well as the way the business manages and shares information with its clients, supporting both collaboration and client experience.

    “We believe that our clients expect more than just professional services, they want easy, secure access to the information that matters to them,” said Chris de Putron, Managing Director at Orbitus. “This is part of our ongoing evolution, combining innovative technology with the human relationships that are at the heart of what we do.”

    Installed and customised by Clarity, the M-Files document management system combined with the Hubshare web based platform offer enhanced document management and simplified sharing of documents, making it easier for Orbitus to support clients and work efficiently across teams.

    Tim Roussel, Business Transformation Sales at Clarity, added: “We’re proud to support Orbitus as they continue to raise the bar. These products help streamline how information flows, giving teams more time to focus on what they do best, and offering clients a smoother, more efficient experience.”


    Pictured: Left to right – Chris de Putron, Managing Director at Orbitus and Tim Roussel, Business Transformation Sales at Clarity

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  • Heather Watson: Wimbledon first-round win ‘slipped through my fingers’

    Heather Watson: Wimbledon first-round win ‘slipped through my fingers’

    Watson was particularly unhappy with her serve as she suffered her ninth first-round exit at Wimbledon.

    “I was just so frustrated because I don’t think I’ve ever missed that many first serves and I didn’t feel bad,” she added.

    “I was trying to change things up, trying to find the court, take a bit of pace off, but just nothing seemed to work.

    “Every time I walked up to that line I was like ‘this is going to be the one, this is where it’s going to change’ and it just never did.

    “I just think that sort of stress built up as the match went on; it was just frustrating that I couldn’t find it, especially because that’s the one shot I’m actually in control of.”

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  • Pakistan hikes air cargo handling charges, some rates increase by up to 100 times

    Pakistan hikes air cargo handling charges, some rates increase by up to 100 times

    The Pakistan Airports Authority (PAA) has raised cargo handling charges across all airports in the country, with certain categories seeing increases of up to 100 times, according to an official notification issued early Wednesday.

    This marks the first revision of cargo tariffs in five years. The decision, approved by the PAA’s executive committee, aims to align the charges with the growing operational costs of managing airport services.

    Under the revised tariff schedule, the charge for transporting pet birds has been raised by 50%, from Rs 200 to Rs 300 per kilogram. Similarly, cargo charges on betel leaves, commonly shipped across the country, have been doubled from Rs 35 to Rs 70 per kilogram.

    General cargo rates have also increased by 25%, moving from Rs 100 to Rs 125 per kilogram. The new tariff also includes air freight fees for pets like cats and dogs, along with various other items categorized as general cargo.

    PAA officials defended the hikes, stating that the charges had remained unchanged for the past five years, despite rising service costs at airports.

    The PAA, established as a public sector autonomous body in 2024, is responsible for managing and developing Pakistan’s airports and air transport services.


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  • Nuclear Energy Agency (NEA) – New version released: The NEA Shielding Integral Benchmark Archive and Database (SINBAD)

    The NEA has released version 2 of the Shielding Integral Benchmark Archive and Database (SINBAD), following the migration to a collaborative development environment and a standardised dataset format. SINBAD, developed since the early 1990s by the NEA and the US Radiation Safety Information Computational Center (RSICC), aims to preserve radiation shielding benchmark experiments for the international community. The SINBAD Task Force, under the NEA Expert Group on Physics of Reactor Systems (EGPRS), now steers its development in collaboration with RSICC.

    The new SINBAD version includes 105 benchmarks for shielding assessments of fission and fusion systems, accelerator shielding and nuclear data evaluations. It represents an internationally recognised resource for validation and verification of radiation transport applications.

    The new SINBAD release is maintained and distributed through the NEA GitLab system provided by the NEA Data Bank, enabling users to give direct feedback and suggest improvements. The SINBAD Task Force manages and evaluates user contributions, following a transparent, version-controlled development process. This development strategy follows successful examples from Open Software development projects, such as the LINUX kernel.

    Organisations from NEA Data Bank member countries can request SINBAD version 2 from the NEA Data Bank, while professionals from non-member countries can request it from RSICC.

    Request SINBAD Version 2 at the NEA Data Bank: SINBAD Version 2, Volumes 1 and 2 (Package NEA-1939).

    Request SINBAD Version 2 at the RSICC: https://rsicc.ornl.gov.

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  • Dalai Lama confirms he will have a successor after his death

    Dalai Lama confirms he will have a successor after his death

    What has happened in Tibet since the Dalai Lama fled to Indiapublished at 10:20 British Summer Time

    Anbarasan Ethirajan
    South Asia Regional Editor

    Image source, Getty Images
    Image caption,

    A photo of Chinese Communist troops building a bridge across one of Tibet’s rivers to transport forces

    For Tibetans, the Dalai Lama’s departure in 1959 was a
    devastating turning point.

    Thousands died fighting Chinese troops after he fled. The
    Tibetan rebellion was brutally suppressed. Many dissidents were deported to
    mainland China.

    More than 80,000 fled their homeland.

    After the Chinese government established the Tibetan Autonomous
    Region (TAR) in 1965 a large number of Tibet’s monasteries and cultural
    artefacts were destroyed.

    Beijing restored its people’s freedom to practice their religion
    in the 1980s, but monks and nuns often complained of persecution.

    China also began a large-scale immigration of the Han Chinese
    which Beijing argued helped the region economically. But Tibetan leaders said
    it threatened their unique culture.

    In 2008, tensions between Tibetan and Han Chinese communities in
    Lhasa erupted into deadly violence that lasted for several days.

    Dalai LamaImage source, Getty Images
    Image caption,

    Photo taken during a government-organised media tour of a school classroom in Lhasa in China’s Tibet Autonomous Region

    Today, Tibet remains tightly controlled by Chinese authorities.

    According to Human Rights Watch, since 2016 China has dramatically accelerated the relocation of rural villagers and
    herders in Tibet. It says the relocations—often to areas hundreds
    of kilometres away—are voluntary and will “improve people’s livelihood” opportunities.

    Beijing also says the region is one of the fastest growing provincial economies, with fresh
    investments and improved living conditions.

    But critics allege the flow of information from Tibet is tightly controlled.

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  • Australia says it cancelled Kanye West's visa over 'Heil Hitler' song – Reuters

    1. Australia says it cancelled Kanye West’s visa over ‘Heil Hitler’ song  Reuters
    2. Minister reveals Kanye West was denied entry to Australia after releasing antisemitic song  Australian Broadcasting Corporation
    3. ‘We don’t need that’: US rapper Kanye West barred from visiting Australia  The Canberra Times
    4. US rapper Kanye West’s Australian visa cancelled  The Mercury
    5. Kanye West barred from Australia over anti-Semitic song  The Nightly

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  • Global Hydrogen Mobility Alliance: Air Liquide joins a strategic partnership in Europe

    Global Hydrogen Mobility Alliance: Air Liquide joins a strategic partnership in Europe

    Air Liquide has joined the newly launched Global Hydrogen Mobility Alliance, a coalition of industry leaders gathering equipment manufacturers, Automotive & Technology suppliers, Energy & Chemicals players. The Alliance is calling for the acceleration of the development of hydrogen mobility to secure Europe’s industrial strength and sustainability. To better understand this initiative, Erwin Penfornis, Vice President of Air Liquide’s Hydrogen Energy business line, answers our questions.

    What does hydrogen mobility offer that electric batteries do not?

    It adds crucial layers of resilience, competitiveness, and system-wide efficiency. Firstly, it requires much less infrastructure investments. Secondly, the full electrification of Europe’s fleet, especially heavy-duty vehicles, would overwhelm grids, so hydrogen storage can help maintain their stability. On top of that, hydrogen can help solve the growing problem of fluctuating renewable power, providing a way to store and use the energy that would otherwise be wasted. Thirdly, hydrogen vehicles provide a range comparable to that of diesel, with fast refueling times (15 minutes for 600+ km range versus 45 minutes for 400 km for battery electric), and lighter weight for increased payload. Thanks to these advantages, hydrogen is crucial for heavy and long-distance transport, which is difficult to decarbonize.

    Why is this technology not broadly adopted yet?

    The technology is ready: it is mature, safe, and reliable. However, for commercial transport operators, whose margins are tight, the Total Cost of Ownership (TCO)1 is the deciding factor. The current price of hydrogen at the pump needs to be optimized, vehicles are still expensive due to a lack of mass production, and the refueling network needs to get denser. Therefore, it is now urgent to bridge this cost gap.

    How does Europe’s progress compare on the global stage?

    Other regions are moving very quickly and decisively. China, for example, is already the world leader in deployment, with more than 28,000 hydrogen trucks and buses on the roads and hundreds of refueling stations in operation as of this year. They have a stated goal of reaching 1 million vehicles by 2030. This isn’t just about catching up; it’s about Europe leveraging its own strengths to lead in a technology that is vital for our industrial future.

    To create that momentum, the Alliance is calling for a “market activation phase.” What does this involve?

    We are calling for a pragmatic and targeted strategy. At the heart of this approach, we advocate for effective public support for the deployment of refueling infrastructure, drawing inspiration from successful programs like the SWiM initiative in the Netherlands. The principle is to simultaneously develop fleets of trucks and the stations that supply them along key corridors. This method reduces investment risks and offers a concrete pathway to meet European objectives. It must be complemented by other incentives, such as road toll exemptions for zero-emission vehicles.

    This pragmatism also applies to technology: we must be technology-neutral and support both fuel cell vehicles and hydrogen combustion engines to accelerate deployment. Finally, on the supply side, while the goal is 100% decarbonized hydrogen, environmental requirements must be introduced progressively to give the entire ecosystem time to adapt.

    What strategic opportunity does the development of a hydrogen economy represent for Europe today?

    The long-term vision is a competitive and self-sustaining hydrogen mobility market that makes our economy stronger while preserving the environment. At Air Liquide, we are already building toward this future, investing across the entire value chain: from large-scale low-carbon hydrogen production, such as our Normand’Hy electrolyzer, to the distribution infrastructure needed to deliver it to end customers, which is the purpose of TEAL Mobility, our joint venture with TotalEnergies.

    We have a unique opportunity to deliver on Europe’s climate commitments and guarantee its energy safety for the future. This path simultaneously strengthens our industrial competitiveness, creating a powerful synergy for progress. We are ready to join forces with public and private partners to make this vision a reality.

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  • Nothing’s latest flagship smartphone teases smoother performance, a snappier camera and reimagined glyphs

    Nothing’s latest flagship smartphone teases smoother performance, a snappier camera and reimagined glyphs

    It’s time to unholster our best ‘Nothing’ based puns, because the UK-based brand has revealed its latest smartphone.

    The Nothing Phone (3) is the company’s latest iteration of its flagship line, teasing improved performance and usability, plus a few AI surprises, at a competitive price.

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  • Maternal and gestational factors associated with congenital anomalies among live births: a nationwide population-based study in Brazil from 2012 to 2020 | BMC Pregnancy and Childbirth

    Maternal and gestational factors associated with congenital anomalies among live births: a nationwide population-based study in Brazil from 2012 to 2020 | BMC Pregnancy and Childbirth

    In this population-based study with more than 26 million live births the findings indicated that women belonging to the most vulnerable social group were exposed to a greater burden of factors that increased the likelihood of having a live birth with CA. However, the patterns of risk factors varied according to the group of anomalies. Maternal education was a risk factor only for neural tube defects, while lack of prenatal care and multifetal gestation were associated with greater odds of having a live birth with CA in all groups, except for those with Down syndrome. Advanced maternal age and previous fetal loss were the factors that increased the odds of CA in all groups.

    Distal risk factors, known as socioeconomic factors, have been shown to increase the odds of children born with CA. Black maternal race/skin color and low education (0 to 3 years), increased the odds of CA by 16% and 8%, respectively. Similarly, Anele et al. (2022) reported that a low education level was associated with a 2.08 times higher risk of births affected by CA, mainly in mothers with higher incomes, indicating the impact of low education on the outcome [27]. Regarding black maternal race/skin color, studies carried out in the United States showed that the risk of birth with CA among African Americans varied according to the CA group, with a greater risk for musculoskeletal malformations and a lower risk for cardiac anomalies [28, 29]. Furthermore, in a study carried out in the southern region of Brazil, Trevilato et al. (2022) reported that black women had 20% higher odds of having children with CA than white women [6]. Both factors are related to greater social vulnerability and are consequently associated with low income [30, 31].

    The contribution of socioeconomic vulnerability to CA has different origins, acts indirectly, and encompasses environmental conditions, such as poor nutrition, as well as social and structural conditions, e.g., lack of access to prenatal care [10, 11, 20, 32]. Thus, we observed that not having had any prenatal consultations during pregnancy or having started late has been shown to increase the odds of birth with CA. Trevilato et al. (2022) reported that women with no prenatal visits had 97% greater odds than women with seven or more prenatal visits of having children with congenital anomalies [6]. Prenatal care assistance allows important guidance on modifiable risks in the mother’s lifestyle, such as smoking, alcohol consumption, diabetes control, and exposure to certain teratogens, to be provided at an early stage of pregnancy, reducing the risk of births with CA [11].

    Women in more vulnerable socioeconomic groups can find difficulties accessing prenatal care since women with lower incomes face barriers such as difficulty covering the cost of services, long waiting times, and difficulties obtaining transportation to reach appointment locations, which can lead to negative attitudes toward health care [33, 34]. Furthermore, Dingemann et al. (2019) reported that women with low education attend fewer prenatal consultations, in addition to having a greater chance of future complications in their children with CA [35]. The absence of prenatal consultations may be related to extreme socioeconomic vulnerability [36, 37]. Furthermore, it was observed that in Brazil, among women who underwent prenatal care, the largest proportion underwent (at least once) an ultrasound (99.7%). However, many congenital anomalies require other complementary exams for accurate diagnosis, which are often not available free of charge for the poorest population [38,39,40].

    Neural tube defects were strongly associated with not having any prenatal consultations during pregnancy and low maternal education. Mothers exposed to these factors may not correctly supplement folic acid in the diet during the critical period of pregnancy in which neural tube development occurs (up to the fourth week of gestation) [27, 41]. It is recommended that supplementation begin as early as possible; ideally, supplementation should be started before pregnancy during conception planning, to reduce the likelihood of birth with neural tube defects [42]. Cui et al. (2021) reported that women with less education and who had unplanned pregnancies had less knowledge about folic acid and had higher odds of not starting to use it before becoming pregnant [43].

    Additionally, there were significant variations in the odds of children being born with CA between regions of the country and CA groups. The leading cause of this variation is underreporting, and the Southeast is the region that best reports births with CA compared to others [7]. The greater chance of mothers living in the Northeast Region having children with neural tube defects has not yet been fully explained. According to a previous study, the Northeast and Southeast regions had the highest prevalence of neural tube defects [44]. The Northeast region of Brazil concentrates almost half of the Brazilian population living in poverty [45], which may help explain the greater odds of residence mothers of having births with neural tube defects, since this condition is highly associated with low income, low education attainment and poor diet (insufficient supplementation) [46, 47]. In addition, the Zika virus epidemic in Brazil in 2014 resulted in an increase in the reporting of live births with microcephaly and other congenital anomalies of the nervous system, especially in the Northeast region [5, 7], which may have contributed to the observed results.

    The odds of having children with cardiac CA also varied widely between regions. Women who lived in the North and Northeast regions were less odds to have children affected by cardiac CA. This result reflects considerable underreporting of this group of CA across regions, which is more pronounced in the country’s poorest regions [7]. A similar result was observed by Salim et al. (2020), who reported fewer cardiac CA notifications in these regions [48]. Early diagnosis of cardiac CA may require a more complex structure than some centers can offer, in addition to trained professionals [49], which leads to underreporting of this group, which is more accentuated in the population and economically vulnerable regions.

    Multifetal pregnancy and fetal loss were also associated with birth with CA. Previous fetal loss can be an indication of previous gestational problems, such as a fetus with severe anomalies. A history of prior anomalies has been shown in other studies to be a risk factor for birth with CA [6, 50], which, therefore, may be related to fetal loss in previous pregnancies. Furthermore, as noted by Al-Dewik et al. (2023), multifetal gestation increased the chances of birth with different types of CA, including cardiac CA and nervous system CA [51], as seen in the present work.

    Maternal biological factors also demonstrated an association with the outcome. Thus, consistent with the literature, advanced maternal age was found to be the factor most strongly associated with the occurrence of births with Down syndrome, as already well known [52]. Additionally, advanced maternal age also elevated the odds of having children born with other CA, such as central nervous system defects and heart defects [52, 53]. The association between advanced maternal age and the risk of chromosomal defects and other CA has been widely recognized, it is seen that the CA risk varies by anomaly type and maternal age. It is worth noting that pregnancies in women under the age of 20 years have also been shown to increase the odds of births with CA, which is primarily attributed to social factors, as early pregnancy may be linked to low income and other lifestyle-related risk factors, such as the use of drugs and alcohol, as previously discussed [54,55,56].

    A relevant aspect of this study was the extensive sample size, as it included all births evaluated nationwide over a long period. Additionally, through the linkage process, it was possible to include live births that were not reported in the SINASC database but were registered in the SIM database. Correcting an information error and substantially enhancing the case group’s size. However, it is important to emphasize that the CA recorded in the SIM were those that were severe enough to result in the individual’s death, which may introduce a bias in this regard. In addition, CA that were not recorded in the SINASC at birth and were not registered in the SIM, were not captured in the notifications and consequently were not included in the analyses. Several factors contribute to this underreporting, including the fact that some CA are not detected at birth because they are not noticeable. In addition, the health team is often not trained to recognize certain more important CA, a capability that varies among Brazilian regions, reinforcing the need for active surveillance of the most important defects [17, 57]. Furthermore, there was no information available on the use of folic acid during pregnancy, which made a more detailed analysis in this regard impossible.

    In summary, this study showed that socioeconomically vulnerable women have an increased odds of having a pregnancy affected by CA, mainly for neural tube defects, due to the sum of the risk factors to which they are exposed. Maternal characteristics such as low education, region of residence, race/black skin color, and late start of prenatal care were associated with the outcome. Biological characteristics, such as advanced maternal age and multifetal gestation, were also shown to be strongly associated with birth with CA. Advanced maternal age had a strong association with birth with Down syndrome, whereas multifetal gestation was mainly associated with neural tube defects. Thus, although many CA are not preventable, primary care measures to reduce associated factors greatly impact preventing births with CA [58, 59]. As noted in this study, there is a great need to identify the factors associated with CA and outcomes at the population level, thereby supporting the establishment of effective public policies that can effectively reduce the incidence of preventable CA, as a broad-coverage support for families wishing to become pregnant, including genetic counseling for families with a history of congenital anomalies in the family, control of maternal infections before conception, nutritional support and folic acid supplementation before conception also, among others, in addition to health actions to monitor and care of those born and living with CA.

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