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ESG Disputes Bulletin – July 2025 – Dentons
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Mature dendritic cell vesicles enhance influenza vaccine effectiveness
Influenza hemagglutinin subunit vaccines are more effective and offer better cross protection against various influenza virus challenges when combined with a mucosal adjuvant that enhances the body’s immune response, according to a study by researchers in the Institute for Biomedical Sciences at Georgia State University.
The study published in the journal ACS Nano shows that immune cell-derived extracellular vesicles, specifically those from mature bone marrow-derived dendritic cells (which are crucial for immune responses), rather than those from immature dendritic cells, are potent mucosal adjuvants for influenza hemagglutinin vaccines.
The influenza hemagglutinin subunit vaccine is a type of influenza vaccine that primarily contains the surface protein hemagglutinin of the influenza virus. Mucosal adjuvants are substances that can enhance the body’s immune response to foreign materials in the mucosa, such as the surface of the respiratory tract, study authors explained.
Existing seasonal influenza vaccines have limited effectiveness against evolved virus strains, so next-generation, cross-protective influenza vaccines are urgently needed. Recombinant protein subunit vaccines have gained attention in vaccine development due to their safety, ease of large-scale manufacturing and affordability. Protein subunit vaccines can be designed to target specific pathogen components, leading to more focused immune responses.
Studies have found that mucosal immunization is a promising strategy against respiratory infectious diseases because it helps prevent the infection and transmission of respiratory pathogens and exhibits potential cross protection. However, the effectiveness of protein vaccines administered mucosally is limited, so there’s a need for safe and effective mucosal adjuvants. This study investigated the potential of extracellular vesicles derived from mature dendritic cells as mucosal adjuvants for influenza hemagglutinin vaccines.
Prior to this study, the mucosal adjuvant potential of extracellular vesicles derived from mature dendritic cells and the underlying mechanisms of action have been unknown.
Immune cell-derived extracellular vesicles, which play crucial roles in intercellular communication and modulating biological responses, are potent mucosal adjuvants for influenza hemagglutinin vaccines.”
Bao-Zhong Wang, senior author of the study and a Distinguished University Professor in the Institute for Biomedical Sciences at Georgia State
“These vesicles exhibit intriguing immunostimulatory activity both in vitro and in vivo,” Wang said. “Specifically, they effectively activated antigen-presenting cells, macrophages and B cells in vitro, and promoted enhanced recruitment of airway immune cells, early lymphocyte activation and robust germinal center formation in mice.”
The study found that intranasal immunization of mice with the influenza hemagglutinin vaccine plus the extracellular vesicle adjuvant from mature bone marrow-derived dendritic cells elicited significant, cross-reactive, and multifaceted humoral and cellular immune responses at both systemic and mucosal sites, conferring complete protection against homologous and heterologous influenza virus challenges.
The researchers pointed out that extracellular vesicles derived from mature dendritic cells have gained significant attention in immunotherapy and vaccine development because they have a variety of immunologically active molecules crucial for effective presentation of antigens (foreign substances that induces an immune response in the body), as well as cell adhesion and fusion.
“These findings underscore the potential of extracellular vesicles from mature bone marrow-derived dendritic cells as a promising adjuvant or immunomodulatory target for the development of mucosal vaccines,” said Chunhong Dong, first author of the study and a postdoctoral fellow in the Institute for Biomedical Sciences at Georgia State. “Given their biocompatibility and solid adjuvanticity, mature bone marrow-derived dendritic cells represent a promising adjuvant candidate for mucosal vaccine development.”
Additional authors of the study include Lai Wei, Wandi Zhu, Joo Kyung Kim, Ye Wang, Priscilla Omotara and Arini Arsana of the Institute for Biomedical Sciences at Georgia State.
The study is funded by the National Institutes of Health (NIH)/National Institute of Allergy and Infectious Diseases (NIAID).
Source:
Journal reference:
Dong, C., et al. (2025). Mature Dendritic Cell-Derived Extracellular Vesicles are Potent Mucosal Adjuvants for Influenza Hemagglutinin Vaccines. ACS Nano. doi.org/10.1021/acsnano.5c08831.
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Metallica hypes up ‘Back to the Beginning’ gig with Black Sabbath
Metallica makes major moves as ‘Back to the Beginning’ gig nears Metallica just landed in Birmingham, the venue for this weekend’s Back to the Beginning concert.
The metal titans, who would be performing at the show which would also mark the iconic Black Sabbath’s final live comeback, wasted no time in taking in some of the Paranoid hitmakers’ landmarks.
Taking to their official Instagram, the Fade To Black hitmakers posted a photo featuring their bassist Robert Trujillo standing in front of the Black Sabbath logo on Mr Murals’ astonishing Sabbath mural on Navigation bridge.
They captioned the image: “The kids have landed in Birmingham.”
A second photo was uploaded minutes later, where the legendary front man, James Hetfield, could be seen throwing the devil horns while sitting between Ozzy Osbourne and Tony Iommi on the Black Sabbath Bench on Black Sabbath Bridge.
The rock band’s guitarist and co-founder, Iommi replied to both these posts with the devil horns emoji.
Back to the Beginning, which will be hosted by actor, Jason Mamoa, is set to take place at Villa Park on Saturday, a place where all four original band members of Black Sabbath grew up.
The upcoming concert also boasts arguably the greatest line-up in metal history where alongside Sabbath, Ozzy and Metallica, sets from Guns N’ Roses, Slayer, Pantera, Gojira, Halestorm, Alice in Chains, Lamb of God, Tool, Rival Sons, Anthrax and Mastodon, would all be featured in the show.
Additionally, the Back to the Beginning promoter and producer, Andy Copping, confirmed to Planet Rock that there will be an additional “two or three” surprise acts as well as a revolving stage.
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Vermeer’s Love Letters — moments of grace from everyday life
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Roula Khalaf, Editor of the FT, selects her favourite stories in this weekly newsletter.
There’s something bewitching about a glimpse of near-tranquillity, a feathery ripple of emotion or a chuckle in a dark room. Vermeer died young, broken by catastrophe on an enormous scale. Yet we revere him now for the way he savoured instants that would otherwise have gone unnoticed, the skill with which he chronicled flickers of deep but inconspicuous feeling.
For the first exhibition in its freshly refurbished home, the Frick has assembled a trio of blazing, murmuring Vermeers, composed of the simplest ingredients: a pair of women, a pen, a table, a sheet of paper, a ray of light. Each of these scenes of letters being written or delivered provides a tantalising peek into an inner life. We don’t know who is using what words to communicate what thoughts, but we can easily imagine how envious the painter must have been of the serenity he depicted. His own home was deluged with children — 11 of them — and his wife Catharina was surely too busy rousting, feeding, bathing and herding them to enjoy much contemplative hush.
The three paintings are deceptively alike. A splendidly clad woman sits, a maid dressed in practical brown stands, and a letter passes between them, or is about to, on its way to or from the outside world. These works give off the poetic emanations of life’s ordinary prose, the grandeur of stilled actions, half thoughts and interrupted daydreams. The act of writing takes on a numinous halo; even a few seconds of nothing much seem saturated with significance. When you’ve come in off the boiling, roiling, stinking Manhattan streets, these immaculate domestic vignettes, hanging in the Frick’s sort-of-domestic setting, offer an interval of private grace.
In the most characteristic of the three, “Woman Writing a Letter with Her Maid” (on loan from the National Gallery of Ireland, Dublin), an elegant, bejewelled lady in a lace-trimmed bonnet and a bodice of pale-gold silk bends over her correspondence. She is focused on the task, her concentration heightened by the sunshine that spills through stained glass, spotlighting the hand that draws the quill across the gleaming page.
The other character has something else on her mind. She turns towards the window, watching out of the corner of her eye, her lips parted in mute curiosity. The writer’s absorption and the attendant’s distraction are both encapsulated in the stick of sealing wax that’s tumbled to the floor, a lone flourish of messiness that neither of them notices.
While the maid looks out, we look in, observing from our position on this side of a curtain that now reads as a muted brown but that in Vermeer’s time shone a bright shade of green. The drape pulls back to reveal a tableau that casts viewers as voyeurs — or detectives. We can’t tell what kind of letter the woman is writing (to a shopkeeper? a lover? a family member far away?), what event in the street has caught her maid’s attention, or what hidden meaning lies in the painting on the wall depicting baby Moses being snatched from the Nile. Vermeer doles out information in drops of mystery.
The Frick’s larger “Mistress and Maid” treats the same subject in a contrasting manner. The action glows against a background so dark that it verges on the crypt-like. Vermeer first adorned the wall with a tapestry and then painted over it to keep attention on the human drama. There’s no visible window, yet light shoots in from the left, glinting off the protagonist’s globular earring and the pearls around her neck.
You can see a trace of Caravaggio in the battle between sunshine and shadow and in the theatrical composition that pushes the figures forward into the viewers’ space. And yet there’s no violence or strain, no bolt of revelation, just a polite encounter across class lines. A maid opens her mouth to speak and passes the letter to her employer, who’s sumptuously dressed in yellow and ermine. The wealthy woman has been writing, but she lays down her pen and glances up, fingers thoughtfully grazing her chin. Perhaps her life is about to change, or maybe the moment will be immediately forgotten. What remains is the exquisiteness of not knowing.
In the “The Love Letter”, which comes from the Rijksmuseum in Amsterdam, we have been exiled from the room entirely. By accident or in secret, we peer through a darkened anteroom, spying on an intimate exchange. The fur-trimmed yellow outfit is familiar and maybe we’ve seen the model before, too, but now she’s playing the cittern — or was, until her maid popped in with a note. Vermeer charges the scene with urgency and hope. The servant reassures the mistress with a soothing smile. A fair-weather seascape on the wall signals smooth sailing ahead.
That was wishful thinking on Vermeer’s part. In 1672, two years after he painted “The Love Letter”, harsher news arrived in the form of a French invasion of the Netherlands. Suddenly unable to sell his own paintings, saddled with those of other artists that he had on consignment, and burdened with a gaggle of children, he fell apart. “He lapsed into such decay and decadence, which he had so taken to heart that, as if he had fallen into a frenzy, in a day and a half he went from being healthy to being dead,” his widow recounted. He was 43 years old.
Catharina soldiered on by trading art for bread. “The Love Letter” was one of two paintings she handed over to a local baker, hoping to redeem them later. She never did. And so this gently optimistic interior became a form of sustenance in a war zone, the instrument of physical as well as spiritual nourishment. Its survival seems like a miracle, but then man-made beauty, even the quiet kind, turns out to be a sturdy shield against desperation.
To August 31, frick.org
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The Gilded Age review — Julian Fellowes’ lavish period drama returns for a diverting third season – Financial Times
- The Gilded Age review — Julian Fellowes’ lavish period drama returns for a diverting third season Financial Times
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National Women’s Soccer League Announces 2026 Schedule Footprint – bayfc.com
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The secret of why Mars grew cold and dry may be locked away in its rocks
The discovery by the Mars rovers of carbonate in sedimentary rock on the Red Planet has enabled planetary scientists to rewind the clock and tell the tale of how Mars’ warmer, watery climate 3.5 billion years ago changed to the barren, dry and cold environment that it is today.
We know that, in the distant past, Mars was warmer than it is today and had liquid water on its surface. We can see evidence for this in the form of ancient river channels, deltas, lakes and even the eroded coastlines of a large sea in the north. Sometime in the past 3.5 billion years, Mars’ atmosphere thinned and its water either froze or was lost to space. The question is, how did that happen?
NASA’s MAVEN – Mars Atmosphere and Volatile EvolutioN – mission arrived at the Red Planet in 2014 charged with studying the loss rate of Mars’ atmospheric molecules to space. However, scientists know that the carbon in Mars’ atmosphere, mostly in the form of carbon dioxide, cannot have been mostly lost to space. That’s because the lighter carbon-12 would preferentially escape rather than the marginally heavier carbon-13 (the difference between the two being one extra neutron), but we don’t see an excess of carbon-13 in Mars’ atmosphere today.
The alternative is that Mars’ atmospheric carbon must have rained out of the atmosphere and subsequently been locked away in the ground, in the form of carbonates embedded in sedimentary rock. The trouble is, searches for carbonates on Mars had always found nothing, until relatively recently.
Both current Mars rover missions – Curiosity climbing Mount Sharp in Gale crater and Perseverance exploring the river delta in Jezero Crater – have discovered carbonates, in the sedimentary rock that form Mount Sharp, and stretching tens of kilometers along the rim of Jezero.
A view of a region nicknamed Ubajara, which is part of the slopes of Mount Sharp and where Curiosity discovered a carbonate mineral called siderite. (Image credit: NASA/JPL–Caltech/MSSS) Because carbon dioxide is a greenhouse gas, it can therefore regulate a planet’s climate. Losing that carbon dioxide as it transforms into carbonate rocks would have had a drastic effect on Mars’ climate.
To determine just how drastic, planetary scientists led by Edwin Kite of the University of Chicago modeled how losing its atmospheric carbon in carbonate rocks has affected how Mars’ climate has changed over the past 3.5 billion years. This is coupled with the increase in solar luminosity as the sun brightens with age (in just over a billion years’ time the sun will be too luminous and hot for life on Earth to survive). As the sun grew hotter, it breathed more heat onto Mars, increasing the planet’s average temperature. This led to more precipitation, causing the carbon dioxide to rain out and become locked away as carbonate.
With the loss of the carbon dioxide’s greenhouse effects, Mars cooled and grew drier. Intermittent spells of high temperatures and shallow liquid water were caused by orbital variations, similar to the Milankovitch cycles on Earth, which are periodic variations in the shape of Earth’s orbit and the tilt of our planet’s axis caused by the gravitational forces of the other planets, and which affect our long-term climate.
The difference between Earth and Mars is that our planet has been able to manage a continuous outgassing of carbon dioxide, mostly from volcanism, to maintain its presence in our atmosphere. Mars, which is about half the diameter of Earth, lost heat from its core more rapidly, which slowed down and ultimately – as far as we can tell – stopped Mars’ volcanic activity. With no active volcanoes, or at least very few, there was nothing to replenish the carbon dioxide in the atmosphere.
These findings help explain the geological evidence of subsequent but increasingly less frequent bursts of liquid water on the surface of Mars during the past 3.5 billion years.
There is one caveat, which is that the study assumes that the abundance of carbonates at Gale crater is typical of the entire Red Planet. Carbonate samples need to be identified in many locations before we can say for sure that this was how Mars lost its greenhouse gas.
The research is published in Nature.
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UK Prime Minister Sir Keir Starmer hosts F1 for 75th year celebration in Downing Street
Formula 1 CEO and President Stefano Domenicali met with British Prime Minister Sir Keir Starmer for a celebration of the sport’s 75th anniversary year – and a discussion about F1’s role in the United Kingdom’s economy – ahead of the British Grand Prix at Silverstone.
Starmer welcomed Domenicali, along with Derek Chang, President and CEO of Liberty Media, and a host of F1 personalities to Downing Street on Wednesday, where they met with the Secretary of State for Science, Innovation and Technology, Peter Kyle, the Secretary of State for Culture Media and Sport, Lisa Nandy, and MPs.
Also present were current drivers including Carlos Sainz, Alex Albon, Ollie Bearman and Esteban Ocon, as well as team bosses James Vowles, Flavio Briatore, Andy Cowell, Jonathan Wheatley and Ayao Komatsu.
Other attendees included leaders of the incoming Cadillac F1 operation Graeme Lowdon and Daniel Towriss, F1 ACADEMY Managing Director Susie Wolff and several F1 ACADEMY drivers, and F1 legends Sir Jackie Stewart, Damon Hill, Martin Brundle and Jenson Button.
Domenicali and Starmer both made speeches at the event, which was also attended by young engineers, interns, scholars, apprentices and graduates from F1’s 10 teams – F1 itself currently funding 50 mechanical engineering students with full scholarships at several UK universities.
F1 plays a huge role in the UK’s economy, contributing £12 billion in value annually, with more than 6,000 people being directly employed, and a supply chain of 4,500 companies employing around 41,000 people.
From next year, a full nine of F1’s 11 teams will have major bases and operations in the UK, with Kick Sauber having yesterday announced a new UK Technology Centre in Bicester.
Meanwhile, F1’s world-leading Media and Technical Centre – which produces International Feed coverage and F1 TV shows at every Grand Prix – is located in Biggin Hill, Kent.
Overall, the UK boasts 16.7 million fans, with around half a million spectators expected at this weekend’s British Grand Prix weekend.
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IND vs ENG: Backfires! Rishabh Pant falls into Ben Stokes’ trap, throws wicket away with reckless shot – WATCH | Cricket News
NEW DELHI: Rishabh Pant’s ultra-aggressive style has often drawn both admiration and criticism, and on Day 1 of the second Test at Edgbaston, it backfired spectacularly. India were beginning to settle into a strong position, but Pant, who had just started looking comfortable, threw away his wicket in a moment of misjudged bravado.The dismissal came in the 48th over of India’s innings, a moment that swung momentum England’s way. Shoaib Bashir, the young off-spinner, was in the middle of a tidy spell when he floated one up invitingly at 74kph.
Pant, sensing an opportunity to put pressure back on the bowler, went for a big hit over long-on. But the delivery was a touch fuller and slower than expected. Pant didn’t get under it properly, and the ball went flat and hard straight to Zak Crawley at long-on. The dismissal left Shubman Gill visibly frustrated at the non-striker’s end as India lost their fourth wicket against the run of play.Pant’s shot selection suggested he was lured into a trap meticulously set up by Ben Stokes and Bashir — a flighted bait that the flamboyant left-hander couldn’t resist. Given the rhythm Pant was in and his recent form, the shot was all the more disappointing.Pant had been in exceptional touch leading into the second Test. He was the standout performer in the series opener at Headingley, becoming only the second wicketkeeper in Test history to score centuries in both innings of a match. That performance not only solidified his role as India’s most dangerous counter-attacker but also propelled him to sixth in the ICC Test batting rankings — a new personal high with 801 rating points.Pant now sits just behind the likes of Joe Root and Harry Brook, trailing the top spot by only 88 points. It’s a return to familiar heights for the 26-year-old, who had previously reached the fifth spot in 2022.Elsewhere in the rankings, Yashasvi Jaiswal retained his No. 4 position, while Shubman Gill dropped to 21st. Among bowlers, Jasprit Bumrah continued to dominate the charts with 907 points, ahead of Rabada and Cummins. Ravindra Jadeja remained the No.1 all-rounder despite a quiet match.Pant’s dismissal at Edgbaston, however, was a reminder that brilliance needs balance — something he’ll look to restore in the remaining matches of the series.
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PTI’s Sanam Javed released from Kot Lakhpat Jail
Pakistan
Released following Lahore High Court bail approval in state-related cybercrime case.
LAHORE (Dunya News) – Sanam Javed, a prominent leader of Pakistan Tehreek-e-Insaf (PTI), was released from Kot Lakhpat Jail after being granted bail by the Lahore High Court.
Justice Farooq Haider approved her bail on June 30, following a case registered by the Federal Investigation Agency (FIA) alleging she uploaded content deemed “anti-state” online. The bail decision led to her release from custody on Tuesday.
The FIA had initiated the case against Mrs Javed under cybercrime laws, accusing her of uploading material that could incite unrest or harm national security narratives. The charges are part of a broader crackdown on political activists using social media platforms to voice dissent.
Sanam Javed’s release marks a significant moment amid ongoing legal battles faced by several PTI leaders in the wake of political tensions and digital expression scrutiny.
Also, in another development, senior leaders of PTI, currently incarcerated in Lahore jail, have issued a formal appeal urging the initiation of comprehensive negotiations to steer the country out of its worsening political and economic crisis.
Also read: PTI warns against attempt to topple KP govt
In a joint statement released from jail on Tuesday, the PTI leaders emphasised that dialogue is the only viable path toward stability. “Negotiations must take place at all levels,” the statement read, adding that both political actors and state institutions need to engage constructively.
The statement further proposed that political negotiations be prioritised as an entry point to broader talks, with incarcerated PTI leaders included in the process. It also called for improved access to PTI’s founding chairman to facilitate the formation of a negotiation committee.
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