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  • Landfall Arrives September 23 — World of Warcraft — Blizzard News

    Landfall Arrives September 23 — World of Warcraft — Blizzard News


    The first major content update to Mists of Pandaria Classic—Landfall—arrives the week of September 23, bringing with it war to Pandaria as the conflict between the Horde and Alliance erupts on the shores of the Krasarang Wilds, an invitation from Wrathion with an opportunity to earn Legendary items, a chance for those itching for a fight to join the Brawler’s Guild for prestige, and more!



    War Has Come to Pandaria


    With the mists parted and Pandaria revealed, the race to claim its power begins. Tensions between the Alliance and Horde heat up as both factions deploy their fleets to the shores of Krasarang Wilds. Players will help establish new bases, battle over resources, and earn favor with either Operation: Shieldwall or the Dominance Offensive through daily quests.



    New Scenarios


    Landfall will usher in five thrilling scenarios to queue for:


    • Alliance:

      • Lion’s Landing: The Alliance base is under attack by the Horde. Work with SI:7 to defeat them.

    • Horde:

      • Domination Point: The Alliance descends upon the base, hoping to nip Garrosh’s fortifications in the bud. Show the enemy that your people are not easily taken advantage of by pushing them off the beach.

    • Both Factions:

      • Assault on Zan’vess: Break the defenses of Zan’vess and recover the invaluable Mantid weapons. You can’t step on these bugs.
      • A Little Patience: The blessed Temple of the Red Crane is the ancestral home of Chi-Ji, the celestial embodiment of hope. From within the temple’s ornate halls, the Red Crane wings out to oppose the despair that spreads through the murky Krasarang Wilds.
      • Dagger in the Dark: Aid Vol’jin in investigating a mysterious source of power… and defend him from attempts on his life.



    Step into the Ring with Brawler’s Guild


    Underground fighting rings have sprung up in Stormwind and Orgrimmar, inviting those itching for a fight to test their mettle for bragging rights. Test your skills in the Brawler’s Guild, facing off against bosses in one-on-one arena battles. Watch others take on encounters or challenge yourself!




    Entry into the Brawler’s Guild is by invitation-only, so you’ll need to acquire a Blood-Soaked Invitation. They can be found on the Black Market Auction house, sent from somebody already in the guild, and occasionally drop from killing certain Horde and Alliance NPCs in Krasarang Wilds. Horde players can make their way to Brawl’gar Arena in Orgrimmar’s Valley of Honor, while Alliance members should head to Bizmo’s Brawlpub, located on the lower level of the Deeprun Tram in Stormwind. Once you arrive, sign up for a fight by speaking with a Bouncer.


    As your Brawler’s Guild rank increases, unlock rewards and activities within the Brawler’s Guild.



    A Word with Wrathion


    The next chapter of the Legendary questline will begin—and Wrathion has taken a keen interest in the escalating war between the Alliance and Horde in the events along the coast of the Krasarang Wilds. Those who have aided the Black Prince in the past will now have new quests to complete as they advance Wrathion’s agenda for Pandaria and their own progress toward Legendary power.


    • Reputation Required: Black Prince – Revered
    • Prerequisites: Complete “Breath of the Black Prince”, unlock Domination Point/Lion’s Landing.
    • Reward: Eye of the Black Prince, which adds a prismatic socket to any Sha-Touched weapon.




    New to Mists of Pandaria Classic with Landfall


    Alt-Friendly Leveling and Reputation Gains


    Leveling and reputation farming just got a whole lot easier in Landfall. The Blacktalon Quartermaster now sells a Grand Commendation once you hit Revered with the Black Prince. Use it, and every character on your account will earn bonus reputation with the faction.


    Leveling from 85–90 has been supercharged, with the experience boost jumping from 10% to 65% meaning less grind and more time diving into endgame content.


    PvP Levels Up


    The growing conflict between the Horde and Alliance has spread across Azeroth. At level 90, mighty combatants can now rise to the challenge and queue for epic conflicts waging in Wintergrasp and Tol Barad.


    The Group Finder now includes a dedicated PvP section with full cross-realm support, making it easier than ever to find matches. Honor and Conquest vendors have returned to their original locations on the Serpent’s Spine. Each Arena Ladder bracket now awards its own set of achievements for Gladiator and Malevolent Gladiator. For example, if you are Malevolent Gladiator in 3v3 and Gladiator in 2v2, you will now get two Achievements—one that says Malevolent Gladiator (2v2) and another for Gladiator (3v3). Players who dominate and miraculously obtain Malevolent Gladiator in 2v2, 3v3, and 5v5 in a single season earn the brand-new “Undisputed Gladiator” title.


    Gear Upgrades


    Want your gear to hit harder? Landfall introduces item upgrades for both PvE and PvP gear, letting you boost your favorite pieces by several item levels. Just bring your currency to the Ethereal merchant in your Pandaria capital and power up your loadout.


    Here’s how it works:


    • PvE Upgrades:

      • PvE Epic Gear: Upgrade by 4 item levels for 1000 Justice Points (instead of 250 Valor). Fully upgrading takes 2000 Justice instead of 500 Valor, as you can upgrade twice, giving you more flexibility without burning precious Valor.
      • Dungeon Rare Gear: Upgrade by 8 item levels for 750 Justice Points.
      • Players can convert their Valor Points into Justice Points at a rate of 1:4 by using the new Commendation of Justice purchased from Commander Oxheart at Niuzao Temple for 125 Valor and granting 500 Justice (550 after the universal 10% Justice Increase).

    • PvP Upgrades:

      • PvP Epic Gear: Upgrade by 4 item levels for 1000 Honor Points (previously 750 Conquest). Fully upgrading now costs 2000 Honor instead of 1500 Conquest, as you can upgrade this gear twice.
      • PvP Rare Gear: Upgrade by 8 item levels for only 750 Honor Points (down from 1500).
      • Players may now convert their Conquest Points into Honor Points at a rate of 1:4 by using the new Commendation of Honor. Purchased from each faction’s Conquest vendors located on the Serpent’s Spine for 125 Conquest, and grants 500 Honor (550 after the 10% Honor Increase).


    You will be able to gear multiple specs more easily and won’t feel locked into a single one.



    Kick Your Graphics Up a Notch


    Just like we did in Cataclysm Classic, the Landfall content update will also include a way for players to turn on High-Definition Textures as an option, which will provide enhanced visual fidelity to many new Mists of Pandaria textures in the game. This update allows for a revitalized game world while preserving the Classic aesthetics of the game.


    You’ll be able to activate this option in-game by selecting Menu, then System, then Graphics. In Battle.net, click Options (next to “Play”), then Modify Install, then HD Textures.



    Pack Light and Take a Portal Instead


    Barnaby Fletcher, a mage hailing from Dalaran and hard on his luck, has found a new home in Pandaria.


    He occasionally visits Halfhill Market to peddle Portal Shards (and take advantage of the Tillers’ hospitality), a new type of seed. Portal Shards grow into consumable items that can be used to open a single-use portal from Sunsong Ranch to a major faction city.


    “Chaotic arcane energy crystalized from high-traffic portals. The soil of Sunsong Ranch will stabilize this energy, yielding a shard that can be broken on the farm to open a one-shot portal to a major city.”



    Ready yourselves, champions! Mists of Pandaria Classic: Landfall will deliver epic battles on war-torn beaches, intense arena showdowns, and powerful gear upgrades to help you conquer the wilds of Pandaria!

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  • Sophie Turner Is Officially Lara Croft in Amazon ‘Tomb Raider’ Series

    Sophie Turner Is Officially Lara Croft in Amazon ‘Tomb Raider’ Series

    Prime Video is ready to send Lara Croft on her next adventure.

    The Amazon-owned streamer has confirmed that Game of Thrones alum Sophie Turner will play Lara Croft in its Tomb Raider series from creator, writer and co-showrunner Phoebe Waller-Bridge. As THR previously reported, Turner emerged as the frontrunner for the coveted role late last year from a short list of actresses that also included Mackenzie Davis, Emma Mackey and Lucy Boynton.

    The series has also brought on Chad Hodge (Good Behavior, Single All the Way) as co-showrunner alongside Waller-Bridge and set a Jan. 19 date for production to begin. Jonathan Van Tulleken (Dope Thief, Shōgun) has also signed on as director and executive producer.

    Turner, whose recent credits include HBO Max’s The Staircase and the ITV/CW miniseries Joan, will be the third actress to play the iconic video game character in a live-action adaptation of Tomb Raider. Angelina Jolie and Alicia Vikander took on the role in previous feature films.

    “I’m so excited to announce the formidable Sophie Turner as our Lara alongside this phenomenal creative team,” Waller-Bridge said in a statement. “It’s not very often you get to make a show of this scale with a character you grew up loving. Everyone on board is wildly passionate about Lara and are all as outrageous, brave, and hilarious as she is. Get your artifacts out — Croft is coming.”

    Said Turner, “I am thrilled beyond measure to be playing Lara Croft. She’s such an iconic character, who means so much to so many — and I am giving everything I’ve got. They’re massive shoes to fill, following in the steps of Angelina and Alicia with their powerhouse performances, but with Phoebe at the helm, we (and Lara) are all in very safe hands. I can’t wait for you all to see what we have cooking.”

    Waller-Bridge, an avowed fan of the video game franchise, began developing Tomb Raider in early 2023, and Prime Video placed a series order for the show in May 2024. Cyrstal Dynamics (which developed the Tomb Raider game franchise), Story Kitchen and Amazon MGM Studios are producing the series.

    Waller-Bridge executive produces via her Wells Street Productions. Hodge, Van Tulleken, Wells Street’s Jenny Robins, Story Kitchen’s Dmitri M. Johnson, Mike Goldberg and Timothy I. Stevenson, Michael Scheel, and Legendary Television also exec produce.

    Turner is repped by Independent Talent Group and Public Eye Communications; Waller-Bridge, by UTA, Independent Talent, McEwan & Penford and Johnson Shapiro; Hodge, by WME, Anonymous Content and Ziffren Brittenham; Van Tulleken, by WME, Untitled Entertainment and Independent Talent; and Story Kitchen, by WME and Pryor Cashman. 

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  • Partnership Between Algae And Bacteria Reveals Secrets Of Evolution

    Partnership Between Algae And Bacteria Reveals Secrets Of Evolution

    Chain of the symbiotic diatom with its N2 fixing cyanobacterial symbiont. In the brightfield (top) the symbiont is inconspicuous inside the host, whereas with epi-fluorescence (bottom) the filaments of the symbionts (arrows) are easily distinguished. Credit Images by Dr. Vesna Grujcic.

    The microscopic alliance between algae and bacteria offers rare, step-by-step snapshots of how bacteria lose genes and adapt to increasing host dependence. This is shown by a new study led by researchers from Stockholm University, in collaboration with the Swedish University of Agricultural Sciences and Linnaeus University, published in Current Biology.

    In some of the most nutrient-poor waters of our oceans, tiny partnerships are hard at work keeping life going. These partnerships, called symbioses, are between microscopic algae known as diatoms and a specific bacteria called cyanobacteria that can take nitrogen from the air and convert it into a form that living things can use.

    In some of these symbioses, the cyanobacteria belong to the genus Richelia, and their main role is to supply nitrogen to their diatom hosts. The diatom hosts are highly active photosynthesizers. Photosynthesis is the metabolic process common to all plants, algae, and some bacteria which use sunlight energy to reduce carbon dioxide (CO2) into chemical energy, usually in the form of sugars.

    A continuum of integration

    How the Richelia physically interact with their diatom hosts vary widely. Some Richelia live attached to the outside of their host, others live in the space between the diatom’s outer cell wall (called a frustule) and inner cell membrane, and some live fully inside. This “continuum” of integration reflects different stages of the partnerships and provides researchers with a unique opportunity to examine the evolutionary process at these different time points of their relationship.

    “In general, as symbionts become more dependent on their hosts, they become more integrated into the host, for example, live inside the host cell, and start to lose genomic information that is redundant with their hosts,” explains co-author, Professor Rachel Foster at Stockholm University.

    Genomes in transition

    Using a comparative genomics approach, postdoctoral researcher Dr. Vesna Grujcic identified that several genomic features of the different Richelia reflect key transitional stages in the evolutionary process.

    “As Richelia become more dependent to their hosts, the set of genes they carry changes a lot. We can see which genes disappear and which stay – giving us a rare view of how these partnerships evolve step by step. Moreover, by comparing Richelia to other nitrogen-fixing cyanobacterial symbionts, we found both shared patterns of gene loss and unique changes that reflect each lineage’s evolutionary path,” says Vesna Grujcic.

    “What excites me most with this research is that different steps on the way to a fully integrated symbiont exist at the same time. This allowed us to study the genetics behind how evolution towards a lifestyle characterized by complete dependence of the symbiont on its host happened,” says Daniel Lundin, from Linnaeus University.

    Grujcic led the pangenome analysis, identifying the set of genes shared by all Richelia (the core genome) as well as the accessory genes that differ between species. Together with Maliheh Mehrshad from the Swedish University of Agricultural Sciences, Grujcic also examined patterns of genome reduction, the size and distribution of spaces between genes known as intergenic spacers, and the extent of pseudogenization – when genes accumulate mutations and lose their function.

    “The level of integration between Richelia and their hosts affects not only genome size and gene content, but also the proportion of coding regions – the parts of DNA that carry instructions for making proteins. Looking at the non-coding DNA, such as the intergenic spacers and broken genes that no longer work (pseudogenes), also tells us a lot about their evolutionary journey,” says Maliheh Mehrshad.

    Coding and noncoding fractions reflect genome degradation stages in Richelia symbionts
    Genome statistics were calculated for the four Richelia genomes derived from the cultures and ten MAGs (Figure 2; Table S1; Figure S1). There is a direct correlation between genome size and GC content in the Richelia spp.: endobionts possess smaller genomes and lower GC content (3.39 Mb ± 0.34 and 34.03% ± 0.88%) compared with periplasmic symbionts (5.17 Mb ± 0.78 and 39% ± 0.07%) and the epibiont (5.98 Mb and 40%) (Figure 2A; Table S1). The number and percentage of coding sequences (CDSs) follows a similar trend where genomes of endobionts have fewer CDSs (2,038 ± 175; 56% ± 4.81%) compared with periplasmic symbionts (6,029 ± 1,548; 67% ± 1.50%) and the epibiont (4,954; 76.09%) (Figures 2B, 2C, and S1A; Table S1).

    The role of ‘jumping genes’

    Another interesting result came from the work of the researcher Theo Vigil-Stenman, a former postdoc at Stockholm University, who characterized all the insertion sequences and transposons – pieces of DNA known as “jumping genes” because they can move genetic information within the genome.

    The researchers had earlier noticed that the genome of the partially integrated symbiont which lives wedged between the outer cell wall of the diatom and the inner cell membrane, only had a slightly smaller genome than the symbiont that attaches to the outside of the host diatom and was missing similar metabolic pathways as the most internal symbiont. Typically, genome size decreases as symbionts become more integrated, or live further inside their respective hosts.

    “We didn’t understand why it could maintain this genome size despite lacking several functional metabolic pathways,” reflects Foster. ”Theo Vigil-Stenman identified that these partially integrated symbiont genomes were full of insertion sequences which inflated their genome size.”

    A model for studying evolution in action

    The research group suggest that these diatom-Richelia symbioses represent a valuable model for studying symbiont genome evolution. The work offers a unique glimpse into evolution in action, as there are few known examples of symbioses caught in transitional stages. Such comparative analysis is rare among planktonic systems and places the diatom–Richelia partnership alongside other notable models of symbiosis.

    Much remains however to learn about how living in symbioses has impacted the evolutionary trajectory of the host diatom genomes and how such models of N2 fixing symbioses can be used in other fields. For example, can such systems lend valuable insights to synthetic biology for making N2-fixing crops?

    Stepwise genome evolution from a facultative symbiont to an endosymbiont in the N2-fixing diatom-Richelia symbioses, current biology

    Astrobiology,

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  • Searching For Missing Interstellar Oxygen In The Far-infrared

    Searching For Missing Interstellar Oxygen In The Far-infrared

    Efficiency factors of crystalline ice grains with carbon inclusions for grain radii of 1 (red), 2 (blue), 5 (green), and 10 µm (brown). The inclusion fraction is set as 0.1. (a) The solid lines indicate the extinction efficiency factors in the 3 µm region. The scattering and absorption efficiency factors for a 2 µm grain are also shown with the dotted and dashed lines. (b) Absorption efficiency factors in the FIR. The colors are the same as in (a). — astro-ph.EP

    Study of interstellar elemental depletion poses an important problem in the interstellar matter that at least a quarter of the total oxygen (∼160 ppm relative to hydrogen) is not accounted for in any known form of oxygen in the translucent or dense interstellar medium (ISM).

    Detailed analysis of the absorption feature of water ice at 3 μm suggests that one fifth of the missing oxygen may reside in 3 μm-sized water ice grains. However, the 3 μm feature becomes complex and weak for grains larger than 3 μm, and thus the NIR spectroscopy is not the best means to study the presence of large ice grains reliably.

    Here we show that sensitive observations of the far-infrared (FIR) features of water ice at 44 and 62 μm enable us to constrain the amount of crystalline water ice grains up to 5 μm or even larger sizes unambiguously. Oxygen is one of the key elements in the ISM chemistry, and [O I] 63 μm is a dominant cooling line in the neutral ISM. Understanding the actual form of the missing oxygen in the ISM is crucial for the study of the ISM and star-formation process.

    To detect the FIR features of the crystalline water ice over the expected strong continuum, a sensitive FIR spectrograph represented by PRIMA/FIRESS is indispensable. Since the feature is broad, the low spectral resolution of R∼130 is sufficient, but accurate relative calibration better than 1% is required.

    Takashi Onaka, Itsuki Sakon, Takashi Shimonishi, Mitsuhiko Honda

    Comments: This paper is part of the JATIS special issue focused on the PRobe Infrared Mission for Astrophysics (PRIMA) probe mission concept. The issue is edited by Matt Griffin and Naseem Rangwala (JATIS VOL. 11 NO. 3 | July 2025)
    Subjects: Astrophysics of Galaxies (astro-ph.GA); Instrumentation and Methods for Astrophysics (astro-ph.IM)
    Cite as: arXiv:2509.01846 [astro-ph.GA] (or arXiv:2509.01846v1 [astro-ph.GA] for this version)
    https://doi.org/10.48550/arXiv.2509.01846
    Focus to learn more
    Journal reference: Journal of Astronomical Telescopes, Instruments, and Systems, 11, 031602 (2025)
    Related DOI:
    https://doi.org/10.1117/1.JATIS.11.3.031602
    Focus to learn more
    Submission history
    From: Takashi Onaka
    [v1] Tue, 2 Sep 2025 00:08:09 UTC (405 KB)
    https://arxiv.org/abs/2509.01846
    Astrobiology,

    Explorers Club Fellow, ex-NASA Space Station Payload manager/space biologist, Away Teams, Journalist, Lapsed climber, Synaesthete, Na’Vi-Jedi-Freman-Buddhist-mix, ASL, Devon Island and Everest Base Camp veteran, (he/him) 🖖🏻

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  • Intravenous cangrelor provides rapid platelet inhibition in cardiogenic shock

    Intravenous cangrelor provides rapid platelet inhibition in cardiogenic shock

    Compared with crushed ticagrelor, intravenous cangrelor provided immediate, effective platelet inhibition, with no increase in major bleeding and lower mortality rates in patients with acute myocardial infarction and cardiogenic shock, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

    Cardiogenic shock is a life-threatening condition in which the heart cannot pump enough blood to meet the body’s needs. It is present in around 4.6% of patients admitted to hospital for acute myocardial infarction (MI) and is associated with in-hospital mortality rates of 44%. Reperfusion using primary percutaneous coronary intervention (PCI) remains the only universal therapeutic approach that improves prognosis.

    Achieving early and effective platelet inhibition is vital for reperfusion at the microcirculatory level in patients with MI complicated with cardiogenic shock. However, major randomized trials on the efficacy and safety of antiplatelet drugs have not included patients with cardiogenic shock. Currently, oral crushed ticagrelor tablets are given; however, the parenteral, direct-acting, reversible P2Y12 inhibitor, cangrelor, may address issues that occur during cardiogenic shock, including poor absorption and impaired liver metabolism. The DAPT-SHOCK-AMI trial – comparing IV cangrelor with crushed ticagrelor – is the first-ever randomized study evaluating the efficacy and safety of antiplatelet agents in this setting.”


    Principal Co-Investigator, Professor Zuzana Motovska from the Charles University and University Hospital Kralovske Vinohrady, Prague, Czechia

    This double-blind, placebo-controlled randomized trial was conducted at 29 sites in Czechia, France, Germany, Poland and Slovakia. Key inclusion criteria were acute MI with an indication for emergency primary PCI and cardiogenic shock that fulfilled at least two of: a) systolic blood pressure <90 mmHg in the absence of hypovolaemia, b) need for vasopressor and/or inotropic therapy and c) signs of organ hypoperfusion. Patients were randomized 1:1 to receive IV cangrelor (IV bolus of 30 μg/kg followed by a continuous infusion at 4 μg/kg) or oral ticagrelor (crushed tablets at a 180-mg loading dose and then a maintenance dose of 90 mg twice daily). In the cangrelor group, 30 minutes before the end of the cangrelor infusion, 180 mg of ticagrelor (crushed tablets) was administered, followed by a maintenance dose of 90 mg twice daily. Cangrelor-placebo and ticagrelor-placebo were administered in the same form as their active counterparts. The study medication was administered to all enrolled patients on top of concomitant aspirin. In total, 605 patients were randomized. The mean age was 65 years and 22.6% were women.

    The primary laboratory endpoint (defined as platelet reactivity index <50% at the end of primary PCI) was achieved in 100% of patients with cangrelor and in 22.1% with ticagrelor (p for superiority<0.0001).

    At 30 days, the primary clinical endpoint was not met: 37.6% of patients in the cangrelor group and 41.0% of patients in the ticagrelor group experienced all-cause death, MI or stroke (difference −3.5%, 95% confidence interval [CI] −11.2% to 4.3%; p for noninferiority=0.13).

    The incidence of all-cause mortality at 12 months was 43.6% in the cangrelor group and 49.2% in the ticagrelor group (difference: −5.6%; 95% CI −13.5% to 2.4%), while the incidence of cardiovascular mortality was 26.8% and 33.2%, respectively ( −6.4%; 95% CI −13.7% to 0.9%).

    The incidence of major bleeding at 30 days was 6.4% in the cangrelor group and 5.2% in the ticagrelor group (p=0.53).

    Improvements were noted in primary PCI outcomes, periprocedural complications, early reinfarction and stent thrombosis rates with cangrelor compared with ticagrelor.

    Principal Co-Investigator, Professor Deepak Bhatt from the Icahn School of Medicine at Mount Sinai, New York, USA, concluded: “Compared with crushed ticagrelor, IV cangrelor provided immediate, effective platelet inhibition and improved several secondary and exploratory clinical outcomes without increasing major bleeding. If verified in larger trials, IV cangrelor could represent a major advancement in the treatment of cardiogenic shock.”

    Source:

    European Society of Cardiology (ESC)

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  • The 25 Greatest of All Time

    The 25 Greatest of All Time

    In honor of Power Players week, Billboard’s Hip-Hop team celebrates the legendary hip-hop labels that molded the superstars we love.

    As Hip-Hop shaped the sound of the streets and transformed the music industry, these legendary record labels brought the genre’s vision to life and helped it dominate the world.

    The iconic labels listed below have nurtured groundbreaking talent, released countless timeless classics, and played a crucial role in shaping hip-hop’s evolution as both an art form and a movement. Without Death Row Records, there would be no Snoop Dogg; without Bad Boy, no Notorious B.I.G.; without Young Money, no Drake.

    The list goes on, but the point is clear: without the right label to steer the ship, many of the rappers we know and love might never have gained the exposure needed to reach superstardom. Before joining Aftermath, Eminem was a struggling battle rapper living in a Detroit trailer park, and Kendrick Lamar might never have risen beyond his Compton roots. The Beastie Boys wouldn’t have been the first rap group to top the Billboard 200 without Def Jam, and Wu-Tang Clan might not have redefined New York hip-hop without Loud Records. Many of the culture’s most visionary labels are just as legendary as the artists they’ve supported — their rags-to-riches stories serving as prime examples of the American Dream.

    As the Billboard staff evaluated which labels truly reign supreme, several factors were considered: the label’s longevity, its chart success, cultural impact, influence, and, of course, the number of classic albums they’ve produced. While major labels did influence a lot of these rosters’ ascents, most of the credit ultimately lies with the indies underneath them — so majors won’t be included in this list. Without further ado, here are the 25 most impactful hip-hop record labels of all time.

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  • Complete brain activity map revealed for the first time in mice – Neurology

    Complete brain activity map revealed for the first time in mice – Neurology

    The first complete activity map of the brain has been unveiled by a large international collaboration of neuroscientists including at UCLA Health. 

    The International Brain Laboratory (IBL) researchers published their findings today in two papers in Nature, revealing insights into how decision-making unfolds across the entire brain in mice at the resolution of single cells. This brain-wide activity map challenges the traditional hierarchical view of information processing in the brain and shows that decision-making is distributed across many regions in a highly coordinated way.

    “This is the first time anyone has produced a full, brain-wide map of the activity of single neurons during decision-making. The scale is unprecedented as we recorded from over half a million neurons across mice in 12 labs, covering 279 brain areas, which together represent 95% of the mouse brain volume. The decision-making activity, and particularly reward, lit up the brain like a Christmas tree,” explained Professor Alexandre Pouget, Co-Founder of IBL and Group Leader at the University of Geneva.

    Brain-wide map showing 75,000 analysed neurons lighting up during different stages of decision-making. Credit: International Brain Laboratory

    The brain map was made possible by a major international collaboration of neuroscientists from multiple universities across Europe and the US. Officially launched in 2017, IBL introduced a new model of collaboration in neuroscience that uses a standardized set of tools and data processing pipelines shared across multiple labs, ensuring data reproducibility. This visionary approach, supported by Wellcome and the Simons Foundation, draws inspiration from large-scale collaborations in physics and biology, such as CERN and the Human Genome Project.

    “We’d seen how successful large-scale collaborations in physics had been at tackling questions no single lab could answer, and we wanted to try that same approach in neuroscience. The brain is the most complex structure we know of in the universe and understanding how it drives behavior requires international collaboration on a scale that matches that complexity,” commented Professor Tom Mrsic-Flogel, Director of the Sainsbury Wellcome Centre at UCL and one of the core members of IBL.

    Researchers across 12 labs used state-of-the-art electrodes for simultaneous neural recordings, called Neuropixels probes, to measure brain activity while mice were carrying out a decision-making task. In the task, a mouse sits in front of a screen and a light appears on the left or right side. The mouse then responds by moving a small wheel in the appropriate direction to receive a reward. 

    However, in some trials, the light is so faint that the animal must guess which way to turn the wheel. The mouse uses how often the light has appeared on the left or right previously to help them make this guess. These challenging trials therefore allowed the researchers to study how prior expectations influence perception and decision-making. 

    The first paper, “A brain-wide map of neural activity during complex behaviour,” showed that decision-making signals are surprisingly distributed across the brain, not localized to specific regions. This adds to a growing number of studies that challenge the traditional hierarchical model of brain function and emphasizes that there is constant communication across brain areas during decision-making, movement onset, and even reward. This brain-wide activity means that neuroscientists will need to take a more holistic, brain-wide approach when studying complex behaviors in future.

    The second paper, “Brain-wide representations of prior information,” showed that prior expectations, our beliefs about what is likely to happen based on our recent experience, are encoded throughout the brain. Surprisingly, these expectations are not only found in cognitive areas, but also brain areas that process sensory information and control actions. For example, expectations are even encoded in early sensory areas such as the thalamus, the brain’s first relay for visual input from the eye. This supports the view that the brain acts as a prediction machine, but with expectations encoded across multiple brain structures playing a central role in guiding behavior responses. These findings could have implications for understanding conditions such as schizophrenia and autism, which are thought to be caused by differences in the way expectations are updated in the brain. 

    “The efforts of our collaboration generated fundamental insights about the brain-wide circuits that support complex cognition; this is really exciting and a major step forward relative to the “piecemeal” approach (1-2 brain areas at a time) that was previously the accepted method in the field. Moreover, our team took rigor and reproducibility very seriously. We developed an entire task force that leveraged our unique, multi-lab approach to determine the extent to which our efforts at standardization enhanced reproducibility. My hope going forward is that both our scientific discoveries and our new insights on reproducibility will have an impact in the field,” commented Dr. Anne Churchland, professor of Neurobiology at the University of California, Los Angeles (UCLA) and one of the core members of IBL.

    “Traditionally, neuroscience has looked at brain regions in isolation. Recording the whole brain means we now have an opportunity to understand how all the pieces fit together. This was too big of a project for any one lab, and a collaboration on this scale was only possible because of the dedication and talent of our staff scientists, who are the best in the business,” commented Dr Kenneth Harris, Professor of Quantitative Neuroscience at UCL and one of the core members of IBL.

    “It’s immensely gratifying to see the IBL deliver the first brain-wide map of neural activity with such high spatial and temporal resolution. The map describes the activity of over 650,000 individual neurons with single-spike resolution. This activity underlies the brain’s sensory and motor activity that constitutes a decision. The map is a fantastic resource that is already being mined by myriad scientists, and yielding unexpected discoveries. It’s a great success for team science and open science,” commented Dr Matteo Carandini, Professor of Visual Neuroscience at UCL and one of the core members of IBL.

    Looking ahead, the team at IBL plan to expand beyond their initial focus on decision-making to explore a broader range of neuroscience questions. With renewed funding in hand, IBL aims to expand its research scope and continue to support large-scale, standardized experiments. As per the IBL model, it will continue to share its tools, data pipelines and platforms with the global scientific community to democratize and accelerate science and enhance data reproducibility.

    “The brain-wide map is undoubtedly an impressive achievement, but it marks a beginning, not the grand finale. The IBL has shown how a global team of scientists can unite, pushing each other beyond comfort zones into uncharted territories no single lab could reach alone. For me, working within the IBL meant constantly confronting the limits of my own knowledge while learning from the extraordinary expertise of colleagues. The IBL has set the highest standards for sharing high-quality data, tools, and resources to accelerate scientific progress. Now, the next horizon is to extend this collective expertise to the entire community. We envision diverse groups of scientists joining IBL to pursue their own projects, leveraging the unique expertise of the IBL staff and benefiting from the open exchange of data and ideas that only large-scale collaboration can offer,” commented Tatiana Engel, Associate Professor at Princeton University and one of the core members of IBL.

    All data from these studies, along with detailed specifications of the tools and protocols used for data collection, are openly accessible to the neuroscience community for further analysis and research. Summaries of these resources can be viewed and downloaded on the IBL website under the sections: DataToolsProtocols

    This research was supported by grants from Wellcome (209558 and 216324), the Simons Foundation, The National Institutes of Health (NIH U19NS12371601), the National Science Foundation (NSF 1707398), the Gatsby Charitable Foundation (GAT3708), and by the Max Planck Society and the Humboldt Foundation.

    Source:

    Read the full papers in Nature

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  • Man of Tomorrow Movie Set as Superman Followup for 2027

    Man of Tomorrow Movie Set as Superman Followup for 2027

    James Gunn has unveiled his next project in his Superman Saga. Man of Tomorrow will be in theaters July 9, 2027, the filmmaker revealed on Instagram.

    The announcement was accompanied by a drawing by DC head Jim Lee featuring Lex Luthor in a green and purple mech suit with Superman leaning against him, a slight smile on his face as he holds a screwdriver. Luthor’s armored suit, designed to battle Superman, has been seen for decades in the comics and in animation, but never in live-action.

    Gunn has been teasing this new feature for weeks, saying that his next project won’t be a direct sequel to Superman, but will feature characters audiences already know from his summer hit.

    “I’ve already finished the treatment for the next story in what I’ll call the ‘Superman Saga,’” Gunn told The Hollywood Reporter last month at the premiere for his TV show Peacemaker. “I’m working on that and hopefully going into production on that not too far away from today.”

    It’s unclear what the story will be, but there was a Superman: Man of Tomorrow animated movie in 2020 that was based on a 2003 mini-series titled Superman: Birthright that was a modernization of the Superman origin story.

    Coming up, DC Studios has filmmaker Craig Gillespie’s Supergirl due out June 26, 2026, with James Watkins’ horror title Clayface slated for Sept. 11, 2026.

    Gunn is coming off of Superman, which earned strong reviews and introduced a slew of new characters to populate the DC Universe, not just Superman (David Corenswet), Lex Luthor (Nicholas Hoult) and Lois Lane (Rachel Brosnahan) but heroes such as Guy Gardner (Nathon Fillion), Mister Terrific (Edi Gathegi) and Hawkgirl (Isabela Merced).

    With $611.6 million globally, Superman stands as the top grossing comic book movie of the year, but the sum also reflects the more challenging theatrical landscape when it comes to superheroes, particularly internationally. (In 2013, Zack Snyder Superman feature Man of Steel topped $670 million globally.)

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  • Hot mic catches Xi and Putin discussing organ transplants and immortality

    Hot mic catches Xi and Putin discussing organ transplants and immortality

    Watch: Xi and Putin overheard discussing organ transplants and living to 150-years-old

    Chinese President Xi Jinping and Russian President Vladimir Putin have been overheard discussing organ transplants as a means of prolonging life on the sidelines of a military parade in Beijing.

    Putin suggested even eternal life could be achievable as a result of innovations in biotechnology, according to a translation of remarks caught on a hot mic.

    The unguarded moment was captured on a livestream carried by Chinese state TV as the two leaders and North Korea’s Kim Jong Un walked together through China’s historic Tiananmen Square.

    Xi and Putin have been in power for 13 and 25 years respectively. Neither has expressed any intention of stepping down.

    Standing shoulder-to-shoulder with the North Korean and Russian leaders, China’s president used his Victory Day spectacle to project an alternate vision for the future of the world order.

    However their private conversation suggests their sights extend beyond the economic and political.

    The exchange was relayed by a Mandarin translator for Putin and a Russian translator for Xi, and has been translated into English by the BBC.

    “In the past, it used to be rare for someone to be older than 70 and these days they say that at 70 one’s still a child,” Xi’s translator could be heard saying in Russian.

    An inaudible passage from Putin follows. His Mandarin translator then added: “With the development of biotechnology, human organs can be continuously transplanted, and people can live younger and younger, and even achieve immortality.”

    Xi’s translator then said: “Predictions are, this century, there’s a chance of also living to 150 [years old].”

    Putin reportedly reprised his remarks later while speaking to Russian media.

    Russian state news agency Tass quoted him as saying: “Modern recovery methods, medical methods, even surgical ones dealing with the replacement of organs, enable humanity to hope for active life to last longer than it does today.

    “Average age is different in different countries but life expectancy will increase significantly”.

    Xi said the world faced a choice between peace and war as China unveiled a huge arsenal of weapons – including nuclear missiles with a global reach – to mark the 80th anniversary of the end of World War Two.

    Wednesday’s parade marked the first time that the Chinese, Russian and North Korean leaders had appeared together publicly, viewed by some observers as a message to the Western nations that have shunned them.

    Putin and Kim joined 24 other dignitaries at the parade, including Iran’s President Masoud Pezeshkian, Pakistan’s PM Shehbaz Sharif, Vietnam’s Luong Cuong and Zimbabwe’s Emmerson Mnangagwa.

    China has sought to position itself as a possible counterweight to the US since the imposition of Donald Trump’s tariffs.

    On Wednesday, the US president accused Xi of conspiring against the US with the leaders of Russia and North Korea.

    In a post on Truth Social, Trump wrote: “Please give my warmest regards to Vladimir Putin and Kim Jong Un as you conspire against the United States of America.”

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  • Home-based hypertension care improves blood pressure control in rural South Africa

    Home-based hypertension care improves blood pressure control in rural South Africa

    Home-based hypertension care led to reductions in systolic blood pressure and improvements in hypertension control in South Africa, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in the New England Journal of Medicine.

    Hypertension is the primary risk factor for stroke and heart disease, which are leading causes of death in South Africa. Despite the wide availability of low-cost, effective therapies, hypertension control remains extremely poor in resource-limited settings. Obstacles include a lack of patient confidence to manage their own hypertension care, overcrowded clinics with long wait times and the cost of transport to clinics. Our trial aimed to assess the effectiveness and implementation of reliable, home-based, technology-supported interventions to improve blood pressure control in low-resourced rural South Africa.”


    Doctor Thomas Gaziano, IMPACT-BP trial’s Co-Principal Investigator, Mass General Brigham (MGB) and Harvard Medical School, Boston, USA

    IMPACT-BP was an open-label, randomized controlled trial conducted at the Africa Health Research Institute (AHRI) in KwaZulu-Natal, South Africa, in which patients were recruited from two public-sector primary healthcare clinics. The implementation study was designed with Co-Principal Investigator, Doctor Mark Siedner of AHRI and MGH, Professor Nombulelo Magula of the University of KwaZulu-Natal, and the KwaZulu-Natal Provincial Department of Health.

    Adult patients were eligible if they had evidence of uncontrolled hypertension as defined by South African Department of Health Guidelines: two measurements of systolic blood pressure (SBP) >140 mmHg and/or diastolic BP (DBP) >90 mmHg, taken a minimum of 6 months apart.

    Patients were randomized to one of three strategies: 1) standard-of-care, clinic-based blood pressure (BP) management; 2) home-based BP self-monitoring supported by the provision of BP machines, community health workers (CHWs) who conducted home visits for data collection and medication delivery, and remote nurse-led care assisted by a mobile application with decision support; or 3) an enhanced CHW group in which BP machines included cellular technology to transmit BP readings automatically to the mobile application. The primary outcome was change in SBP from enrolment to 6 months.

    In total, 774 patients were randomized. The mean age was 62 years, 76% were women, 14% had diabetes and 47% were living with HIV.

    Compared with standard-of-care, mean SBP at 6 months was lower in the CHW group (−7.9 mmHg; 95% confidence interval [CI] −10.5 to −5.3; p<0.001) and the enhanced CHW group (−9.1 mmHg; 95% CI −11.7 to −6.4; p<0.001). In the standard-of-care group, hypertension control at 6 months was 57.6% compared with 76.9% in the CHW group and 82.8% in the enhanced CHW group. Improved BP with home-based care appeared to persist at 12 months.

    Severe adverse events (2.7%) and deaths (1.0%) were uncommon overall and similar across groups. Retention in care remained more than 95% in both intervention groups, with patients reported to have enjoyed managing their own hypertension.

    Summarising, Doctor Siedner said, “This study is an important example of how making models of chronic disease care more convenient – taking it from the clinic to patients’ homes and letting them play a major role in their own care – can substantially improve hypertension outcomes.”

    Of particular value was that the programme was successful in a community that has historically had low access to care. Professor Magula concluded: “Achieving hypertension control in over 80% of people in a predominantly Black African community in rural South Africa is a clear example that equitable health care access can be achieved in disadvantaged communities. Similar models of care that address structural barriers could be considered to improve hypertension control in other remote and resource-limited settings. Expansion of the model to include the care of people with multiple comorbidities may also be valuable.”

    Source:

    European Society of Cardiology (ESC)

    Journal reference:

    Siedner, M. J., et al. (2025). Home-Based Care for Hypertension in Rural South Africa. New England Journal of Medicine. doi.org/10.1056/nejmoa2509958

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