Category: 3. Business

Cachexia, a complex wasting syndrome, impacts an estimated 9 million people worldwide.^[i] In people living with cancer, cachexia can diminish the tolerance of therapies and is linked to reduced survival rates. Currently, there are no FDA-approved treatments targeting its underlying cause.

Over time, the way researchers and physicians understand cachexia has evolved, with growing focus on uncovering the biology behind this devastating disease.

In an effort to address a critical gap in care and help patients and their caregivers, a team of Pfizer scientists launched a promising research program targeting this often-overlooked condition by working to understand the underlying biology of the disorder, leveraging cross-functional expertise, and seeking early patient input early throughout the development process. This effort led us to focus on the growth differentiation factor 15 (GDF-15) and its potential as an important therapeutic target for this devastating condition.

Understanding Cancer Cachexia: A Three-Part Explainer Series

Graham Ferrier, Global Oncology Medical Lead and one of the dedicated minds behind the program, breaks down the complexities of this condition in a three-part explainer series, shedding light on just how serious cachexia is:

1. What is cachexia?
This video offers an overview of cachexia—what causes it, how it differs from general weight loss, and why it is so difficult to manage in people living with cancer.

2. Who does cachexia affect and how?
Learn about who cachexia affects, how it adds to the challenges faced by people living with cancer, and why it remains so difficult to treat.

3. What is GDF-15?
Discover how our scientists are identifying the underlying biology of cancer cachexia.

 

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^[i] Cleveland Clinic. Cachexia (Wasting Syndrome). Cachexia (Wasting Syndrome): Symptoms & Treatment (clevelandclinic.org). Accessed August 19, 2025.

Black Friday is almost here and there will be plenty of discounts across categories, including beauty, home, kitchen, sneakers and more. In fact, many retailers have already launched a number of early deals. And though there are thousands of sales to take advantage of, every year, a handful of items sell out in a snap. Last year, for example, a popular doll my daughter had been begging for was 50% off. I added it to my cart but then paused, debating whether she really needed it. By the time I made my decision — poof — it was sold out.

To help you avoid missing out on deals, I spoke with retail experts to try and gather intel on what items are most likely to sell out this year. Check out what they had to say below.

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How I determined what is most likely to sell out during Black Friday

To predict what is most likely to sell out during Black Friday sales in 2025, I spoke with retail experts about trends they’re seeing across shopping categories. I also asked them what types of items have historically been popular during Black Friday sales.

On top of that, I spoke with other NBC Select editors who have covered Black Friday sales for many years. I asked them what type of items they’ve noticed tend to sell out each year.

It is important to note that these are just predictions based on trend forecasting about what is likely to be popular this year along with historical data on previous years’ top sellers.

What items are most likely to sell out during Black Friday?

According to the experts I spoke with, there are a handful of categories that tend to be most popular during Black Friday and Cyber Monday, while other categories tend not to be as popular. For example, clothing and shoe sales tend not to be as popular during Black Friday because those items tend to be on sale more frequently throughout the year, says Ronald Goodstein, an associate professor of marketing at Georgetown University’s McDonough School of Business. Below are categories that experts said are most likely to have items that will sell out:

• Electronics: Tech products like televisions tend to be very fast sellers, says Goodstein. When it comes to TVs specifically, many brands will deeply discount older, discontinued models to clear any remaining stock — this means there likely isn’t a ton of stock and they will sell out quickly, says NBC Select’s tech reporter Harry Rabinowitz. In addition to televisions, Rabinowitz says that the latest Apple Watches and Apple Airpods Pro often go out of stock when they’re on sale. “Apple AirPods Pro 3 launched in September and they have never been on sale,” he says. “I’m assuming they will go on sale for Black Friday and may sell out.”

• Video game consoles and games: According to Adobe, video game consoles are expected to see a 1,040% uptick in sales over Black Friday and Cyber Monday compared to the daily average of sales between January and August. Likewise, video games are expected to see a 1,010% increase during this time. Given the demand, it is likely that popular consoles and games may sell out quickly. Henry Jin, a professor of supply chain management at Miami University’s Farmer School of Business, predicts that the Nintendo Switch 2 will be “the number one hot item.”

• Small household appliances: Goodstein says that small household appliances also tend to sell quickly during Black Friday sales — especially higher-priced items that don’t get marked down very often. Historically, cooking appliances from Ninja and vacuums from Dyson and Bissel’s Little Green Machine have been popular with NBC Select readers. Last year, the Amazon Smart Plug and the Kitchen Mama Auto Electric Can Opener were also top sellers amongst NBC Select readers.

• Beauty and wellness tech: Adobe also predicts high-ticket beauty tech like the Dyson’s Airwrap Multi Styler will be popular come Black Friday and Cyber Monday. “Beauty products that go viral on TikTok — like the Dyson Airwrap — always seem to sell out,” says NBC Select editor Mili Godio. Wellness tech is also predicted to be popular, with Adobe reporting an estimated 1,055% increase in fitness tracker sales over the shopping holiday and the Oura Ring 4 being particularly popular.

Early deals to shop now before they sell out

As mentioned, there are a number of early Black Friday deals to shop. If you want to avoid items selling out, it’s smart to start shopping now. Below, I gathered some deals that are live now on products experts said are more likely to sell out.

This 55-inch premium television from Sony has a QD-OLED screen that provides crisp, clear image quality and is powered by Google TV, giving you access to thousands of apps, according to the brand. This television is particularly good for PlayStation gamers, as it automatically adjusts the HDR settings on your gaming console to the TV for detailed, high-contrast scenes, according to Sony.

The Dyson Airwrap has been historically a big seller when it goes on sale for Black Friday. Though the jury is still out on whether that tool will be discounted this year, Shark’s FlexStyle has similar benefits and is currently at its lowest price ever. A similar version from the brand made our list of the best blow dryer brushes because you can use the tool as a hair dryer, or you use one of the auto-wrap curlers to add waves to your hair. NBC Select associate social media editor Caitlin Cusack uses this dryer and says it has cut the time she spends on her hair in half. The FlexStyle also uses intelligent heat control to automatically adjust the temperature to avoid burning your hair, according to the brand.

Garmin makes some of our favorite watches for health tracking and, currently, the Forerunner 965 is at its lowest price ever. It has a touchscreen, plus button controls on either side of the watch face. You’ll get up to 23 days of battery life in smartwatch mode and 31 days in GPS mode, according to the brand. “I’ve tested a lot of Garmin watches, including other versions of the Forerunner series — they’re the best option for runners,” says Rabinowitz. “With the 965 in particular, you get some of Garmin’s most advanced training metrics plus maps and navigation built right into the watch.”

The PlayStation 5 version of this popular game has a feature called QB DNA that leverages real quarterback play calls and game situations to allow you to enact player-specific behaviors and signature throwing motions, according to Madden. You can also play in different weather conditions, just like in real life, which impacts how your players move and creates new challenges.

Dyson deals are always a favorite amongst NBC Select editors and readers and this cordless vacuum from the brand is currently on sale. You’ll get up to 40 minutes of suction on a full charge and the Motobar cleaner head works on all types of floors, according to the brand. It comes with a hair screw attachment that’s good for picking up pet hair and a crevice attachment to help you reach between couch cushions and other tight spots. You can also detach the top to use it as a hand vacuum.

I’ve had my eye on a new KitchenAid mixer for quite some time and have noticed that when they do go on sale, they tend to run out quickly. This model comes in 19 colors, all of which are marked down. The mixer comes with a five quart stainless steel bowl, a plastic splash guard and three attachments — a whisk, paddle and dough hook. The tilt head makes it easy to add ingredients to the blow and it has 10 different speeds.

Last year a similar food storage set from Rubbermaid was a top seller amongst NBC Select readers. I have a number of these containers and use them for all my meal prepping needs. I like that they are BPA-free and that the lids have steam vents for when I stick them in the microwave. You get a total of 22 containers of varying sizes with matching lids with this set.

Meet our experts

At NBC Select, we work with experts with specialized knowledge and authority based on relevant training and/or experience. We also ensure all expert advice and recommendations are made independently and without undisclosed financial conflicts of interest.

• Ronald Goodstein is an associate professor of marketing at Georgetown University’s McDonough School of Business.
• Henry Jin is a professor of supply chain management at Miami University’s Farmer School of Business.

Why trust NBC Select?

I’m a contributor at NBC Select and a journalist who regularly covers beauty, home and lifestyle. I have also covered major sales — including Amazon Prime Day and Black Friday — for over a decade.

Catch up on NBC Select’s in-depth coverage of tech and tools, wellness and more, and follow us on Facebook, Instagram, Twitter and TikTok to stay up to date.

The government has been urged to take control of the sale of the Telegraph through an auction run by a body such as the UK competition regulator or the Cabinet Office.

Peers called on the culture secretary, Lisa Nandy, to wrest the sale process from RedBird IMI, which is majority funded by the United Arab Emirates, in questions put to Labour minister Fiona Twycross in the House of Lords on Wednesday.

RedBird IMI has been forced to restart the sale process after its junior partner in the joint venture, Gerry Cardinale’s US-based RedBird Capital Partners, pulled out of a deal to buy the Daily and Sunday Telegraph on Friday.

Christopher Fox, the Liberal Democrats spokesperson for business, said the Telegraph needed an independent “white knight” buyer and argued that those involved in previous attempts to buy the titles should not be allowed to lead the process. He added that the Department for Culture, Media and Sport (DCMS) had mishandled the situation and suggested the Cabinet Office or an external adviser with experience of complex media transactions should take control instead.

The Conservative peer, Michael Forsyth, suggested that the government should turn to the Competition and Markets Authority (CMA) to pursue a “proper auction and have normal order restored”.

Lady Twycross said the government was “acutely aware” that the protracted sale has left the Telegraph and its staff “in limbo for too long”, but said that the culture department would continue to control the process.

She said: “The secretary of state has adhered to the letter of the law and diligently carried out her quasi-judicial responsibilities. There is no basis to the suggestion that the decision should be made elsewhere. Securing a swift outcome in the public interest is a priority for her.”

Nandy could refer Redbird IMI’s bid to the CMA to investigate whether it breaches laws on foreign state ownership, using new powers under the Foreign State Influence (FSI) regime.

If the CMA were to deem the bid unlawful, Nandy could order an independent sale of the titles at a market-led price, potentially run by the regulator and supervised by the independent directors who have overseen the Telegraph during the protracted process.

Another option could be to coordinate the process through the Cabinet Office.

However, IMI, which is controlled by Abu Dhabi’s Sheikh Mansour bin Zayed al-Nahyan, has said that while it purchased an “economic interest” in the Telegraph it has never sought to influence or control the titles.

The newspaper group has been in limbo for two and a half years after Lloyds Bank put it up for sale, having seized control from its former owners, the Barclay family, over unpaid debts.

RedBird IMI, which took control of the titles in late 2023, was forced to put them back on the market after new legislation banned foreign states from owning UK newspapers. It has been unable to find a buyer at the £500m price it is seeking.

Most media analysts believe that the titles are worth about £350m.

Any move to force a sale, especially one resulting in a significant loss for RedBird IMI, which would anger the UAE, would be politically unattractive for the government.

Becket McGrath, a partner at Euclid Law, said: “The mechanism [to force a sale] seems to act as a sword of Damocles here. Government can force a sale by initiating a process but the current owners are looking to sell anyway. So it would just trigger a lot of bureaucracy and forces a bigger loss on them. It is not tempting for the government.”

RedBird Capital’s aborted bid, which could have been referred to Ofcom and the CMA on public interest grounds, would also have included small stakes from the owner of the Daily Mail and billionaire Sir Leonard Blavatnik.

A new sales process could revive interest from GB News investor Sir Paul Marshall, who acquired the Spectator in September 2024 for £100m, and Lord Rothermere’s Daily Mail & General Trust (DMGT).

However, a bid from DMGT, which already handles the Telegraph’s printing and advertising sales, would trigger regulatory scrutiny over competition concerns.

Lord Saatchi and Lynn Forester de Rothschild also tabled a bid last August for £350m, plus a promise of further payments dependent on performance, which was also rejected by RedBird IMI.

A rare example of the first functioning calculating machine in history looks likely to stay in France after Christie’s withdrew it from auction pending a definitive ruling from a Paris court on whether or not it can be exported.

La Pascaline, developed by the French mathematician and inventor Blaise Pascal in 1642, when he was just 19, and billed as “the most important scientific instrument ever offered at auction”, had been expected to fetch more than €2m (£1.8m).

But the auction house withdrew the ebony-inlaid instrument from sale on Wednesday after the Paris administrative court, responding to an urgent appeal by scientists and researchers, provisionally suspended its authorisation for export late on Tuesday.

“Given its historical and scientific value, La Pascaline is likely to be classified as a ‘national treasure’ … which prevents the issuance of an export certificate,” the court said, adding its provisional decision “prohibits it from leaving the country”.

Christie’s said it was suspending the sale, part of an auction of the library of the late collector Léon Parcé, given the court’s decision, pending its final ruling – which could take several months – and “in accordance with the instructions of our client”.

The instrument, in private hands since 1942, is one of only eight authentic Pascalines in existence. Christie’s described the machines as “nothing less than the first attempt in history to substitute the work of a machine for that of the human mind”.

Pascal developed the instruments, the first attempt to “mechanise mental calculation”, to simplify the work of his father, who was in charge of a court tasked with restoring order to tax revenue collections in northern France, Christie’s said.

The philosopher devised several models, each using different units for a specific purpose, such as calculating decimals, commercial transactions or taxes. This one, for surveyors, calculates in units of measurement including feet, inches and fathoms.

The group of eminent scientists and researchers, including the 2021 Nobel physics laureate Giorgio Parisi, asked the administrative court last week to block La Pascaline’s potential export, arguing it should be classified a “national treasure” and remain in France.

La Pascaline was “the origin of modern computing” and had made France “the cradle of the computing adventure: a revolution that transformed our understanding of the world”, they said in an impassioned op-ed published by Le Monde.

It was “one of the key jewels in France’s intellectual and technological heritage”, they said, accusing the state of committing an “astounding blunder” in granting Christie’s export authorisation rather than giving French institutions time to mount a bid.

“What a sad admission of disinterest in our scientific heritage,” the scientists wrote. “What a misunderstanding of Pascal, engineer, mathematician, philosopher, writer, a personality like no other, whose 400th birth anniversary we celebrated in 2023.”

The fact that five Pascalines were already in French public collections – the other two are in Germany – did not diminish this one, they said, because all have their own characteristics and this one was little known to the scientific community.

“It is vital that it enter a public collection so that it can be studied,” they added, describing La Pascaline as “a shining symbol of a unique alliance of history, science and technology” that reflected “a philosophy of learning that honours France”.

The culture ministry said an export certificate had been issued last May following standard procedures, with two experts – one from the National Centre of Arts and Crafts and the other from the Louvre museum – approving the decision.

The loss of more than 2,000 jobs at the World Health Organization (WHO) “will leave the world less healthy and less safe”, experts have warned.

The global health body said it expected to lose 2,371 posts – nearly a quarter of its workforce – by June 2026 as it deals with budget cuts after the US withdrawal from the organisation in January. At that point the WHO had 9,401 staff members.

Analysts and campaigners said the cuts, made under financial pressure, would probably leave the WHO less able to help countries facing disease outbreaks.

Pete Baker, the deputy director of global health policy and a fellow at the Center for Global Development, said: “WHO staffing cuts are a regrettable but inevitable outcome of US withdrawal and lower-than-hoped-for contributions by other countries. The loss of expertise will leave the world less healthy and less safe.

“Now, more than ever, WHO needs a clear, strategic vision to navigate its new fiscal reality. Instead, these cuts are aimed at global and Africa-based staff, at a time when WHO should be doubling down on its global work – such as coordinating responses to pandemics and other health threats – and providing limited country support to the poorest nations, most of which are in Africa.”

The highest number of cuts – 805 posts – will be in the WHO’s Geneva-based headquarters. Its African regional office will be the next worst affected, losing 638 of 2,541 posts according to documents posted online.

Dr Githinji Gitahi, chief executive of Amref Health Africa, said although the cuts were expected, “it is rapid in nature, and with little transition planning”.

“With these cuts, certain functions, especially disease surveillance, supply chain management and emergency response will inevitably be impacted. African governments are going to have to lift more weight than before,” he said.

Eloise Todd, the executive director and founder of Resilience Action Network International, said: “At a time when we face increasing health threats worldwide, reduced capacity will severely impact the WHO’s ability to play the role member states ask of them.”

About half of the reduction in headcount would be achieved through natural attrition such as retirements or the end of temporary contracts, the WHO said, and the rest through “position abolition”.

The cuts process has been turbulent inside the WHO, with junior staff sending an anonymous open letter in August claiming that senior staff were being shielded from the cuts and many high-cost positions kept.

In a lengthy email sent from the WHO chief, Dr Tedros Adhanom Ghebreyesus, to staff, seen by the Guardian, he said the year had been “one of the most difficult in WHO’s history”. He said the process of cutting positions had involved “painful conversations” with staff, who had expressed “their pain, anxiety and, in some cases, their anger”.

WHO documents presented to member states at a briefing on Wednesday show that the number of senior directors will reduce from 65 to 38, a 42% cut that returns their numbers to around 2017 levels. Entry-level professionals will see numbers cut by 37%, from 291 to 183.

Michel Kazatchkine, a senior fellow at the Global Health Center, Geneva Graduate Institute, described the WHO’s presentation as “a politically correct document showing how the balance between grade, regions, gender [etc] has been kept in the 2,000-plus cuts that were announced”.

He added: “It does not say much about the choices made at senior level, and how much the specific added value of people versus other criteria has been guiding decisions.”

Kazatchkine said what was needed was a clear agreement from the WHO’s governing body, the World Health Assembly, on its core mandate, and what it should leave to other bodies such as Unicef or the Global Fund.

“And then,” he said, “assess the needed budget, the needed human resources and fundraise strategically rather than adjusting manpower and activities to financial pressure.”

The cuts were “not necessarily irreversible” in a rapidly moving landscape, he said, adding that adequate financing and adequate manpower were vital to keep the WHO “independent in a heavily politically charged environment”.

Ghebreyesus told staff the WHO had faced a difficult financial situation even before the US announced its intention to withdraw in January, and had sought to change its funding mechanisms to provide greater stability. However, the US decision, “combined with funding cuts from other countries, left us facing a salary gap of about $500m [£382m],” he said.

In a speech to member states, he said there was still a funding gap of $1bn for 2026 and 2027, and asked for support to close it.

Uber has been hit with legal demands to stop using its artificial intelligence driven pay systems, which have been blamed for significantly reducing the incomes of the ride hailing app’s drivers.

A letter before action – sent to the US company by the non-profit foundation, Worker Info Exchange (WIE), on Wednesday – is understood to allege that the ride hailing app has breached European data protection law by varying driver pay rates through its controversial algorithm.

James Farrar, the director of WIE, said: “Uber has leveraged artificial intelligence and machine learning to implement deeply intrusive and exploitative pay-setting systems that have damaged the livelihoods of thousands of drivers.

“Through this collective action, we intend to get a fairer deal for drivers and ensure Uber is held financially accountable for the harm caused by this unlawful use of AI.

“This case is … about securing transparent, fair and safe working conditions for all platform workers.”

The proposed legal case is expected to be filed in Amsterdam, where Uber is based in Europe. The moves come after the WIE partnered with Oxford University during the summer to publish research on Uber driver pay.

The academic paper found that many Uber drivers were earning “substantially less” an hour – while the company was taking a significantly higher share of fares – since the ride hailing app introduced a “dynamic pricing” algorithm in 2023. Dynamic pricing variably sets pay for drivers and fares for passengers and is a later iteration of Uber’s “surge pricing”, which increased fares during periods of peak demand.

The Oxford University research said: “Our findings suggest that post-dynamic pricing, many aspects of Uber drivers’ jobs have gotten worse. Average pay per hour on the app is stagnant, and is lower in real terms in the year following the introduction of dynamic pricing.”

The WIE argued that Uber had trained its algorithms “by using the drivers’ own historic personal data by observing their working practices.

“Under the GDPR, drivers are entitled to demand that Uber stop using this technology, revert to the previous method of transparent pay-setting with a human in the loop, and compensate the drivers for their losses.”

An Uber spokesperson said: “Drivers choose Uber because we offer flexibility over where and when they work, and transparency over every trip they take – including the fare, destination, and their own earnings, before they decide whether to accept. The study WIE collaborated on is not accurate and relies on incomplete and selective data.

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“The researchers themselves admit that their analysis ‘does not enable [them] to isolate the causal effect of dynamic pricing on pay’, making any conclusions about driver earnings misleading. We are proud that thousands of drivers continue to make the positive choice to work on Uber as passenger demand and trips continue to grow.”

The WIE alleges that, while Uber announced dynamic pricing in 2023, the “legal harm” commenced in 2020 with “upfront pricing” – where a passenger would be quoted a set fare for a trip.

The workers’ foundation added that if Uber failed to comply with its “demands to cease these practices and compensate affected drivers”, it intended to “bring collective proceedings before the Amsterdam district court under the Netherlands’ collective redress law”.